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VRMAEWFGKTARPAILAASRSARLRHAAERMPLTRQVVRRFVPGESQDDVLGASTGLLDSGRFISIDYLG EDTTDSEQATRTVSAYLSLLDALAQRSDAVHTGVRPLEISLKLSALGQALPRDGERIALENAQLLCAKAD QAGVWVTADAEDHTTTDSTLNIVRELRADFPGLGTVLQAYLKRTYADCVDLSGKGSRIRLCKGAYDEPAA VAHRDPEDVDVAYLRCLRVLMEGDGYPMVASHDPAIIEAAGLMARETGRGPGDYEYQMLYGIREAEQRRL AGVGHHMRVYVPFGEQWYGYFVRRIAERPANMTFFLRALVSGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1331 | - | - | 100% (323) | proline dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1220 | - | 1e-121 | 65.62% (317) | proline dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2172 | - | 3e-05 | 25.49% (204) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv1188 | - | 1e-121 | 65.62% (317) | proline dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4252 | putA | 1e-116 | 63.84% (318) | proline dehydrogenase, PutA |
| M. avium 104 | MAV_1332 | - | 1e-115 | 64.26% (319) | proline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5117 | - | 1e-119 | 68.37% (313) | proline dehydrogenase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0933 | putA | 1e-115 | 63.21% (318) | proline dehydrogenase, PutA |
| M. vanbaalenii PYR-1 | Mvan_4525 | - | 1e-122 | 70.29% (313) | proline dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5117|M.smegmatis_MC2_155 ------------------MGIFDRVARPAILAASR-SQRLRATAERLPVT
Mvan_4525|M.vanbaalenii_PYR-1 ------------------MSVFDKIARPVILAASR-REGLRRAAERMSVT
Mb1220|M.bovis_AF2122/97 -----------------MAGWFAHTLRPAMLAAGR-SDRLGRIVERSPLT
Rv1188|M.tuberculosis_H37Rv -----------------MAGWFAHTLRPAMLAAGR-SDRLGRIVERSPLT
MMAR_4252|M.marinum_M -----------------MTRLFAHTVRPAMLAASR-ADRLRRTLEHSSVT
MUL_0933|M.ulcerans_Agy99 -----------------MTRLFAHTVRPAMLAASR-ADRLRRTLEHSSVT
MAV_1332|M.avium_104 -----------------MAGLFAHTLRPAILAAGR-RPGLRRAAEALPVT
MAB_1331|M.abscessus_ATCC_1997 ---------------MRMAEWFGKTARPAILAASR-SARLRHAAERMPLT
Mflv_2172|M.gilvum_PYR-GCK MTRIGGDEHLVSEVETLVRRWLDDAAGHRVAPAARRLADVLRDPGGLDFT
: : .*.* : .*
MSMEG_5117|M.smegmatis_MC2_155 RRVVDRFVAGETVPEALDATAALRASGR---------------LVTIDYL
Mvan_4525|M.vanbaalenii_PYR-1 RKVVRRFVPGESTADVITAVGDLRDSHR---------------LVSIDYL
Mb1220|M.bovis_AF2122/97 RGVVRRFVPGDTLDDVVDIVTALRDSGR---------------YLSIDYL
Rv1188|M.tuberculosis_H37Rv RGVVRRFVPGDTLDDVVDIVTALRDSGR---------------YLSIDYL
MMAR_4252|M.marinum_M RRVVRRFVPGETVDSVLDVVGALRDSGR---------------CVSIDYL
MUL_0933|M.ulcerans_Agy99 RRVVRRFVPGETVDSVLDVVGALRDSGR---------------CVNIDYL
MAV_1332|M.avium_104 RRVVHRFIAGETIDSALDSVTALRDSGR---------------CVSVDHL
MAB_1331|M.abscessus_ATCC_1997 RQVVRRFVPGESQDDVLGASTGLLDSGR---------------FISIDYL
Mflv_2172|M.gilvum_PYR-GCK VGFVDRVIRPDDPRVAAANLRELARTAPGFLPWHLRLLIRLGAAVSVVLP
.* *.: : . * : :.:
MSMEG_5117|M.smegmatis_MC2_155 GEDTTSKEDADNTVAAYLALLEGLKS--DSDAK-VRPLEVSLKLSALGQA
Mvan_4525|M.vanbaalenii_PYR-1 GEDVTDADAADATVEAYLTLLDALAGRGETAAA-VRPLEVSLKLSALGQA
Mb1220|M.bovis_AF2122/97 GENVTDADDAAAAVRAYLGLLDVLGRRGDIACDGVRPLEVSLKLSALGQA
Rv1188|M.tuberculosis_H37Rv GENVTDADDAAAAVRAYLGLLDVLGRRGDIACDGVRPLEVSLKLSALGQA
MMAR_4252|M.marinum_M GENVTDVDDAAETVRAYLNLLDVMGRRNDAGRDGVRPLEVSVKLSALGQA
MUL_0933|M.ulcerans_Agy99 GENVTDVDDAAQTVRVYLNLLDVMGRRNDAGRDGVRPLEVSVKLSALGQA
MAV_1332|M.avium_104 GEDVSDADDADAAVRVYLELVDRLGCLGDG--AAVRPLEVSLKLSALGQS
MAB_1331|M.abscessus_ATCC_1997 GEDTTDSEQATRTVSAYLSLLDALAQRSDAVHTGVRPLEISLKLSALGQA
Mflv_2172|M.gilvum_PYR-GCK GVVIPIASRALREMVGHL-LADATDARLGRSIERIRRRGVNLNVNLLGEA
* . . * : :* * : :* :.:::. **::
MSMEG_5117|M.smegmatis_MC2_155 LP-RDGEKIALENAHTICAK------------------------------
Mvan_4525|M.vanbaalenii_PYR-1 LP-RDGEKIALENARAICER------------------------------
Mb1220|M.bovis_AF2122/97 LD-RDGQKIALDNARAICER------------------------------
Rv1188|M.tuberculosis_H37Rv LD-RDGQKIALDNARAICER------------------------------
MMAR_4252|M.marinum_M LE-RDGQKIALDNARTICER------------------------------
MUL_0933|M.ulcerans_Agy99 LE-RDGQKIALDNARTICER------------------------------
MAV_1332|M.avium_104 LD-RDGEKIARENAWAICAA------------------------------
MAB_1331|M.abscessus_ATCC_1997 LP-RDGERIALENAQLLCAK------------------------------
Mflv_2172|M.gilvum_PYR-GCK VLGRREARRRLTGTERLLARPDVDYVSIKVSASVPPHSVWAFDEAVDHIE
: * : .: :
MSMEG_5117|M.smegmatis_MC2_155 -----------ARDIEAWVTVDAEDHTTTDSTLSIVRDLR----TEFDWL
Mvan_4525|M.vanbaalenii_PYR-1 -----------AQRAGVWVTVDAEDHTTTDSTLAIVRELR----VDFDWV
Mb1220|M.bovis_AF2122/97 -----------AERVGAWVTVDAEDHTTTDSTLSISGDLR----VDFPWL
Rv1188|M.tuberculosis_H37Rv -----------AERVGAWVTVDAEDHTTTDSTLSISGDLR----VDFPWL
MMAR_4252|M.marinum_M -----------AEQVGVWVTVDAEDHTTTESTLSIAGDLR----VDFAWL
MUL_0933|M.ulcerans_Agy99 -----------AEQVGVWVTVDAEDHTTTESTLSIAGDLR----VDFAWL
MAV_1332|M.avium_104 -----------AQRAGVWVTVDAEGHTATDSTLRIVRDLR----REFDWL
MAB_1331|M.abscessus_ATCC_1997 -----------ADQAGVWVTADAEDHTTTDSTLNIVRELR----ADFPGL
Mflv_2172|M.gilvum_PYR-GCK QSLLPLFTQAATAATPKFINLDMEEYRDLELTMAVFTRLLDRPELRALEA
: ::. * * : : *: : *
MSMEG_5117|M.smegmatis_MC2_155 GTVLQAYLKRTRADCAEFA----------ASGARIRLCKGA---------
Mvan_4525|M.vanbaalenii_PYR-1 GTVLQSHLKRARADCAEFA----------ASGARIRLCKGA---------
Mb1220|M.bovis_AF2122/97 GTVVQAYLRRTLADCAELA----------AVGARVRLCKGA---------
Rv1188|M.tuberculosis_H37Rv GTVVQAYLRRTLADCAELA----------AVGARVRLCKGA---------
MMAR_4252|M.marinum_M GTVVQAYLRRTLDDCQELA----------SVGARVRLCKGA---------
MUL_0933|M.ulcerans_Agy99 GTVVQAYLRRTLDDCQELA----------SVGARVRLCKGA---------
MAV_1332|M.avium_104 GVALQAYLRRTLGDCEEFA----------AAGARVRLCKGA---------
MAB_1331|M.abscessus_ATCC_1997 GTVLQAYLKRTYADCVDLS----------GKGSRIRLCKGA---------
Mflv_2172|M.gilvum_PYR-GCK GIVLQAYLPDALGAMIRLQDWARDRRQRGGAGIKVRLVKGANLPMEHVEA
* .:*::* : : . * ::** ***
MSMEG_5117|M.smegmatis_MC2_155 -YDEPASVAYRDPDEVTDSYLTCLRILMAGRGYP--MVASHDPEIIAAVP
Mvan_4525|M.vanbaalenii_PYR-1 -YAEPASVAFRDRDDVTDSYLQCLRILMAGRGYP--MVASHDPEILGAVP
Mb1220|M.bovis_AF2122/97 -YDEPASVAYRDAAQVTDSYLRCLRVLTAGRGYP--MVATHDPVIIAAVP
Rv1188|M.tuberculosis_H37Rv -YDEPASVAYRDAAQVTDSYLRCLRVLTAGRGYP--MVATHDPVIIAAVP
MMAR_4252|M.marinum_M -YDEPESVAYRDRVEVTDSYLRCLQVLMAGSGYP--MVASHDPEIIATVA
MUL_0933|M.ulcerans_Agy99 -YDEPESVAYRDRVEVTDSYLRCLQVLMAGSGYP--MVASHDPEIIATVA
MAV_1332|M.avium_104 -YDEPASLAYRDPAAVTDSYLRCLRVLMAGSGYP--MVASHDPAIIEAAP
MAB_1331|M.abscessus_ATCC_1997 -YDEPAAVAHRDPEDVDVAYLRCLRVLMEGDGYP--MVASHDPAIIEAAG
Mflv_2172|M.gilvum_PYR-GCK SLHGWPVATWPTKQDTDTNYKRVLNYALQPDRIANVRIGVAGHNLFDVAY
: . * *. . :. . :: ..
MSMEG_5117|M.smegmatis_MC2_155 ALAREYHRGVDD-FEYQMLYNIRDGEQRRLADEGNHVRVYVPFG-----Y
Mvan_4525|M.vanbaalenii_PYR-1 SMAREYGRGVDD-FEYQMLYGIRDAEQRRLAEAGNHIRVYVPFG-----T
Mb1220|M.bovis_AF2122/97 GITRESGRSQGD-FEYQMLYGVRDDEQRRLTGAGNHVRVYVPFG-----T
Rv1188|M.tuberculosis_H37Rv GITRESGRSQGD-FEYQMLYGVRDDEQRRLTGAGNHVRVYVPFG-----T
MMAR_4252|M.marinum_M GMAHESGRSAND-FEYQMLYGIRDEEQWRLVGAGSQVRVYVPFG-----T
MUL_0933|M.ulcerans_Agy99 GMAHESGRSAND-FEYQMLYGIRDEEQWRLVGAGSQVRVYVPFG-----T
MAV_1332|M.avium_104 SLARESGRGTGE-FEYQMLYGIRDDEQRRLAEAGHTVRVYVPFG-----T
MAB_1331|M.abscessus_ATCC_1997 LMARETGRGPGD-YEYQMLYGIREAEQRRLAGVGHHMRVYVPFG-----E
Mflv_2172|M.gilvum_PYR-GCK AWILAGRRGVRDGVEFEMLLGMADAQAEAVRATVGSLLLYVPVVHPEDFD
*. : *::** .: : : : : :***.
MSMEG_5117|M.smegmatis_MC2_155 EWYGYFVRRLAERPANLTFFLRALAERR----------------------
Mvan_4525|M.vanbaalenii_PYR-1 QWYGYFVRRLAERPANLTFFLRALAERRG---------------------
Mb1220|M.bovis_AF2122/97 RWYGYFLRRLAERPANLAFFLRALTDRRRARGCAER--------------
Rv1188|M.tuberculosis_H37Rv RWYGYFLRRLAERPANLAFFLRALTDRRRARGCAER--------------
MMAR_4252|M.marinum_M QWYGYFMRRLAERPANLGFFLRALVK------------------------
MUL_0933|M.ulcerans_Agy99 QWYGYFMRRLAERPANLGFFLRALVK------------------------
MAV_1332|M.avium_104 QWYGYFMRRLAERPANLTFFLRALAARRH---------------------
MAB_1331|M.abscessus_ATCC_1997 QWYGYFVRRIAERPANMTFFLRALVSGG----------------------
Mflv_2172|M.gilvum_PYR-GCK VAIAYLVRRLEEGSSHQNFMSAVFELHSDDMLFQRERERFVASLAAVDDD
.*::**: * .:: *: .:
MSMEG_5117|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4525|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1220|M.bovis_AF2122/97 --------------------------------------------------
Rv1188|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4252|M.marinum_M --------------------------------------------------
MUL_0933|M.ulcerans_Agy99 --------------------------------------------------
MAV_1332|M.avium_104 --------------------------------------------------
MAB_1331|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK VPLPNRRQDRRADDPAAAVRAEFSNVADTDPALPGNRAWGRAVTGRIAGS
MSMEG_5117|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4525|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1220|M.bovis_AF2122/97 --------------------------------------------------
Rv1188|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4252|M.marinum_M --------------------------------------------------
MUL_0933|M.ulcerans_Agy99 --------------------------------------------------
MAV_1332|M.avium_104 --------------------------------------------------
MAB_1331|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK TAGRSAVDEHTVTTVDGLEAVISRGVDAGARWAALSGAERAAVLRRAAAT
MSMEG_5117|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4525|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1220|M.bovis_AF2122/97 --------------------------------------------------
Rv1188|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4252|M.marinum_M --------------------------------------------------
MUL_0933|M.ulcerans_Agy99 --------------------------------------------------
MAV_1332|M.avium_104 --------------------------------------------------
MAB_1331|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK LEARRATLLEVMAAETGKTLDQGDPEVSEAIDFANYYASLAEKLDRVDGA
MSMEG_5117|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4525|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1220|M.bovis_AF2122/97 --------------------------------------------------
Rv1188|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4252|M.marinum_M --------------------------------------------------
MUL_0933|M.ulcerans_Agy99 --------------------------------------------------
MAV_1332|M.avium_104 --------------------------------------------------
MAB_1331|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK IARPVGLTVVTPPWNFPVAIPAGSTLAALAAGSAVVIKPTTQARRCGSVM
MSMEG_5117|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4525|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1220|M.bovis_AF2122/97 --------------------------------------------------
Rv1188|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4252|M.marinum_M --------------------------------------------------
MUL_0933|M.ulcerans_Agy99 --------------------------------------------------
MAV_1332|M.avium_104 --------------------------------------------------
MAB_1331|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK VEALWDAGIGRDTLQLVHLDEGELGARLISDARVDRVILTGAFDTAALFR
MSMEG_5117|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4525|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1220|M.bovis_AF2122/97 --------------------------------------------------
Rv1188|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4252|M.marinum_M --------------------------------------------------
MUL_0933|M.ulcerans_Agy99 --------------------------------------------------
MAV_1332|M.avium_104 --------------------------------------------------
MAB_1331|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK SFRPDLVLLAETSGKNAIVVTPHADVDLAVKDLVYSAFGHAGQKCSAASL
MSMEG_5117|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4525|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1220|M.bovis_AF2122/97 --------------------------------------------------
Rv1188|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4252|M.marinum_M --------------------------------------------------
MUL_0933|M.ulcerans_Agy99 --------------------------------------------------
MAV_1332|M.avium_104 --------------------------------------------------
MAB_1331|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK GILVGSVARSARFRDQLVDAVTSLNVGYPTDPTVQMGPVIEPADGKLLRA
MSMEG_5117|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4525|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1220|M.bovis_AF2122/97 --------------------------------------------------
Rv1188|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4252|M.marinum_M --------------------------------------------------
MUL_0933|M.ulcerans_Agy99 --------------------------------------------------
MAV_1332|M.avium_104 --------------------------------------------------
MAB_1331|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK LTTLGPGEKWLVAPRQLDDSGRLWSPGVRTGVRRGSEFHLTEYFGPVLGL
MSMEG_5117|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4525|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1220|M.bovis_AF2122/97 --------------------------------------------------
Rv1188|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4252|M.marinum_M --------------------------------------------------
MUL_0933|M.ulcerans_Agy99 --------------------------------------------------
MAV_1332|M.avium_104 --------------------------------------------------
MAB_1331|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK MEARDLDEAIAMQNQVDYGLTAGLHSLDRHEVERWIDRVEAGNAYVNRST
MSMEG_5117|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4525|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1220|M.bovis_AF2122/97 --------------------------------------------------
Rv1188|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4252|M.marinum_M --------------------------------------------------
MUL_0933|M.ulcerans_Agy99 --------------------------------------------------
MAV_1332|M.avium_104 --------------------------------------------------
MAB_1331|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK VGAVVARQPFGGWKKSAVGAGAKAGGPNYLIGLTDWESAPAQQAGRLSPA
MSMEG_5117|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4525|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1220|M.bovis_AF2122/97 --------------------------------------------------
Rv1188|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4252|M.marinum_M --------------------------------------------------
MUL_0933|M.ulcerans_Agy99 --------------------------------------------------
MAV_1332|M.avium_104 --------------------------------------------------
MAB_1331|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK MREFLSAAGRLDLSAEDREFLGRSARSDALAWEQEFGIARDVAGLTAEKN
MSMEG_5117|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4525|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1220|M.bovis_AF2122/97 --------------------------------------------------
Rv1188|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4252|M.marinum_M --------------------------------------------------
MUL_0933|M.ulcerans_Agy99 --------------------------------------------------
MAV_1332|M.avium_104 --------------------------------------------------
MAB_1331|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK VLRYRPVPVTVRAEDGHTASLLRVVAAGLLAGAAITVSTPAPPASAVADL
MSMEG_5117|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4525|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1220|M.bovis_AF2122/97 --------------------------------------------------
Rv1188|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4252|M.marinum_M --------------------------------------------------
MUL_0933|M.ulcerans_Agy99 --------------------------------------------------
MAV_1332|M.avium_104 --------------------------------------------------
MAB_1331|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2172|M.gilvum_PYR-GCK LHMRGVTLRVDDAEHWRKLLRGNAPARVRLIGGSREAFAGAGEGRADVAL
MSMEG_5117|M.smegmatis_MC2_155 -----------------------------------------
Mvan_4525|M.vanbaalenii_PYR-1 -----------------------------------------
Mb1220|M.bovis_AF2122/97 -----------------------------------------
Rv1188|M.tuberculosis_H37Rv -----------------------------------------
MMAR_4252|M.marinum_M -----------------------------------------
MUL_0933|M.ulcerans_Agy99 -----------------------------------------
MAV_1332|M.avium_104 -----------------------------------------
MAB_1331|M.abscessus_ATCC_1997 -----------------------------------------
Mflv_2172|M.gilvum_PYR-GCK YAQPVVEAGRIELLTFLREQAVAVTAHRFGSPTTLADGLFA