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NAAQHADVLILGGGSAGYSCALRASQLGMSVTLIEADKLGGTCLHRGCIPTKALLHTAELADNSRTAADF GIRTRFDGVDMTAVHAYKQSVVSRLHKGLEGLVANRKITVVHGVGRYLGPRSVDVDGTVYTGDAVVLATG SAPRNIPAIPTSFRIVTSDHALELSYVPERAIVLGGGVIGVEFASLWTSLGSSVTIVESLPRLLAGEDNW ASETLERSLRRRGIAVKTSSMVTDAADTGDGVIVTLEGGQTLTADVLLVAVGRQPQSQALADAGIDVDRG FVRVDDRLATNHAGVYAVGDLVAGQQLAHRGFAHGILVAEVIAKGDPVPVAEHLIPRVTYSHPEVASVGL TEAAAREEYGEITTTVYDLAGNGKSQILRTSGGIKVIRRGPADGDGAIVGIHCVGDRVGELIGEAQLMVG WEALPTEVRPFMHAHPTQNEALGEALLALAGTPLHKHS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0894c | - | - | 100% (459) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4127c | - | 1e-67 | 35.71% (462) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3014 | - | 3e-46 | 29.26% (458) | mercuric reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0471 | lpd | 7e-68 | 35.93% (462) | dihydrolipoamide dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0114 | - | 6e-70 | 36.13% (465) | dihydrolipoamide dehydrogenase |
| M. tuberculosis H37Rv | Rv0462 | lpd | 7e-68 | 35.93% (462) | dihydrolipoamide dehydrogenase |
| M. leprae Br4923 | MLBr_02387 | lpd | 8e-66 | 33.76% (465) | dihydrolipoamide dehydrogenase |
| M. marinum M | MMAR_0785 | lpd | 1e-69 | 35.76% (467) | dihydrolipoamide dehydrogenase Lpd |
| M. avium 104 | MAV_4687 | lpdA | 9e-70 | 36.36% (462) | dihydrolipoamide dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0903 | lpdA | 5e-70 | 36.36% (462) | dihydrolipoamide dehydrogenase |
| M. thermoresistible (build 8) | TH_4200 | - | 2e-69 | 35.82% (469) | PUTATIVE dihydrolipoamide dehydrogenase |
| M. ulcerans Agy99 | MUL_2214 | lpd | 7e-71 | 36.15% (462) | dihydrolipoamide dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0794 | - | 4e-69 | 35.93% (462) | dihydrolipoamide dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0471|M.bovis_AF2122/97 ---MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCI
Rv0462|M.tuberculosis_H37Rv ---MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCI
MMAR_0785|M.marinum_M MGAVTHYDVVVLGAGPGGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVGCI
MUL_2214|M.ulcerans_Agy99 ---MTHYDVVVLGAGPAGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVGCI
MAV_4687|M.avium_104 --MTSHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCI
MLBr_02387|M.leprae_Br4923 ---MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVVEPKYWGGICLNVGCI
Mflv_0114|M.gilvum_PYR-GCK ---MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCI
Mvan_0794|M.vanbaalenii_PYR-1 ---MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCI
MSMEG_0903|M.smegmatis_MC2_155 ---MTHFDVVVLGAGPGGYVAAIRAAQLGLNTAIVEPKYWGGVCLNVGCI
TH_4200|M.thermoresistible__bu VEAVSHYDVVVLGAGPGGYVAAIRAAQLGQKTAIIEPRYWGGVCLNVGCI
MAB_0894c|M.abscessus_ATCC_199 MNAAQHADVLILGGGSAGYSCALRASQLGMSVTLIEADKLGGTCLHRGCI
* **::**.*..** .*:**:*** ..:::*. ** **: ***
Mb0471|M.bovis_AF2122/97 PSKALLRNAELVHIFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGV
Rv0462|M.tuberculosis_H37Rv PSKALLRNAELVHIFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGV
MMAR_0785|M.marinum_M PSKALLRNAELAHIFTKDAKAFGISGEATFDYGVAFDRSRKVAEGRVAGV
MUL_2214|M.ulcerans_Agy99 PSKALLRNAELAHIFTKDAKAFGISGEATFDYGVAFDRSRKVAEGRVAGV
MAV_4687|M.avium_104 PSKALLRNAELAHIFTKEAKTFGINGEATFDYGAAFDRSRKVAEGRVAGV
MLBr_02387|M.leprae_Br4923 PSKVLLHNAELAHIFTKEAKTFGISGDASFDYGIAYDRSRKVSEGRVAGV
Mflv_0114|M.gilvum_PYR-GCK PSKALLRNAELAHVFHKDAKTFGISGDVSFDYGAAFDRSRKVADGRVAGV
Mvan_0794|M.vanbaalenii_PYR-1 PSKALLRNAELAHIFTKEAKTFGISGEASFDYGAAFDRSRKVADGRVAGV
MSMEG_0903|M.smegmatis_MC2_155 PSKALLRNAEIAHMFNKEAKTFGISGEATFDYGAAFDRSRKVADGRVAGV
TH_4200|M.thermoresistible__bu PSKALLRNAELASIFTRDAKLFGIQGEVTFDYGAAFDRSRKVADGRVSGV
MAB_0894c|M.abscessus_ATCC_199 PTKALLHTAELADNSRTAADFGIRTRFDGVDMTAVHAYKQSVVSRLHKGL
*:*.**:.**:. *. .* .. .:.* . *:
Mb0471|M.bovis_AF2122/97 HFLMKKNKITEIHGYGTFADANTLLVDLNDGGTES---VTFDNAIIATGS
Rv0462|M.tuberculosis_H37Rv HFLMKKNKITEIHGYGTFADANTLLVDLNDGGTES---VTFDNAIIATGS
MMAR_0785|M.marinum_M HFLMKKNKITEIHGYGKFTDANTLSVDLNDGGTEK---VTFDNAIIATGS
MUL_2214|M.ulcerans_Agy99 HFLMKKNKITEIHGYGKFTDANTLSVDLNDGGTEK---VTFDNAIIATGS
MAV_4687|M.avium_104 HFLMKKNKITEIHGYGRFTDPHTLAVELNDGGTET---VTFDNAIIATGS
MLBr_02387|M.leprae_Br4923 HFLMKKNKITEIHGYGRFTDANTLSVELSEGVPETPLKVTFNNVIIATGS
Mflv_0114|M.gilvum_PYR-GCK HFLMKKNKITEVHGYGRFTGPNSIEVEPTGDGEEGPVKLEFDNAIIATGS
Mvan_0794|M.vanbaalenii_PYR-1 HFLMKKNKITEIHGYGKFTGPNSIEVDLN-DG--GTEKLEFDNAIIATGS
MSMEG_0903|M.smegmatis_MC2_155 HFLMKKNKITEIHGYGKFTGPNSLEVALN-DG--GTEKVEFSNAIIATGS
TH_4200|M.thermoresistible__bu HFLMKKNKITEIHGYGRFTDAHTIEVELNEGGTEQ---VTFDNAIIATGS
MAB_0894c|M.abscessus_ATCC_199 EGLVANRKITVVHGVGRYLGPRSVDVDGTVYTG--------DAVVLATGS
. *: :.*** :** * : ...:: * . . .::****
Mb0471|M.bovis_AF2122/97 STRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYVLKNYG
Rv0462|M.tuberculosis_H37Rv STRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYVLKNYG
MMAR_0785|M.marinum_M STRLVPGTSLSTNVVTYEEQILTRELPKSIIIAGAGAIGMEFGYVLKNYG
MUL_2214|M.ulcerans_Agy99 STRLVPGTSLSTNVVTYEEQILTRELPKSIIIAGAGAIGMEFGYVLKNYG
MAV_4687|M.avium_104 STRLVPGTSLSANVVTYEEQILSRELPESIIIAGAGAIGMEFGYVLHNYG
MLBr_02387|M.leprae_Br4923 KTRLVPGTLLSTNVITYEEQILTRELPDSIVIVGAGAIGIEFGYVLKNYG
Mflv_0114|M.gilvum_PYR-GCK STRLVPGTSLSENVVTYEKQILTRELPGSIIIAGAGAIGMEFAYVLKNYG
Mvan_0794|M.vanbaalenii_PYR-1 STRLVPGTSLSENVVTYEDQILSRELPGSIVIAGAGAIGMEFAYVMKNYG
MSMEG_0903|M.smegmatis_MC2_155 STRLVPGTSLSENVVTYETQILSRELPGSIIIAGAGAIGMEFAYVLKNYG
TH_4200|M.thermoresistible__bu STKLVPGTSLSENVVTYEKLIMTRELPGSIVIAGAGAIGMEFGYIMANYG
MAB_0894c|M.abscessus_ATCC_199 APRNIPAIPTSFRIVTSDHALELSYVPERAIVLGGGVIGVEFASLWTSLG
.: :*. * .::* : : :* :: *.*.**:**. : . *
Mb0471|M.bovis_AF2122/97 VDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIADGGS-
Rv0462|M.tuberculosis_H37Rv VDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIADGGS-
MMAR_0785|M.marinum_M VDVTIVEFLPRALPNEDAEVSKEIERQFKKLGVKIRTGTKVESISDDGS-
MUL_2214|M.ulcerans_Agy99 VDVTIVEFLPRALPNEDAEVSKEIERQFKKLGVKIRTGTKVESISDDGS-
MAV_4687|M.avium_104 VEVTIVEFLPRALPNEDADVSKEIEKQFKKLGVKILTGTKVESISDDGS-
MLBr_02387|M.leprae_Br4923 VDVTIVEFLPRAMPNEDAEVSKEIEKQFKKMGIKILTGTKVESISDNGS-
Mflv_0114|M.gilvum_PYR-GCK VDVTIVEFLPRALPNEDAEVSKEIEKQYKKLGVKILTGTKVEKIEDDGK-
Mvan_0794|M.vanbaalenii_PYR-1 VDVTIVEFLPRALPNEDAEVSKEIEKQYKKLGVKILTGTKVEKIQDDGS-
MSMEG_0903|M.smegmatis_MC2_155 VDVTIVEFLPRALPNEDAEVSKEIEKQYKKLGVKILTGTKVEGIADDGS-
TH_4200|M.thermoresistible__bu VDVTVVEFLPRVLPNEDPEVSREIEKQFKKLGVKIHTGTKVESITDNGAG
MAB_0894c|M.abscessus_ATCC_199 SSVTIVESLPRLLAGEDNWASETLERSLRRRGIAVKTSSMVTDAADTGDG
.**:** *** :..** .*. :*:. :: *: : *.: * * *
Mb0471|M.bovis_AF2122/97 -QVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIG
Rv0462|M.tuberculosis_H37Rv -QVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIG
MMAR_0785|M.marinum_M -AVTVVVSKDGKSEELKADKVLQAIGFAPNVEGYGLDKAGVALTDRKAIG
MUL_2214|M.ulcerans_Agy99 -AVTVVVSKGGKSEELKADKVLQAIGFAPNVEGYGLDKAGVALTDRKAIG
MAV_4687|M.avium_104 -QVTVVVSKDGNSQELKAAKVLQAIGFAPNVEGYGLEAAGVALTDRKAIG
MLBr_02387|M.leprae_Br4923 -HVLVAVSKDGQFQELKADKVLQAIGFAPNVDGYGLDKVGVALTADKAVD
Mflv_0114|M.gilvum_PYR-GCK -QVTVTVSKNDKTEELKADKVMQAIGFAPNVEGFGLDKAGVELTDRKAIG
Mvan_0794|M.vanbaalenii_PYR-1 -TVTVTVSKDGKTDELKADKVLQAIGFAPNVEGFGLETTGVQLTDRRAIG
MSMEG_0903|M.smegmatis_MC2_155 -TVKVTVSKDGKTEELKADKVLQAIGFAPNVEGYGLEAAGVELTDRKAIG
TH_4200|M.thermoresistible__bu GSVVVKVSKDGESSELKADKVLQAIGFAPNVDGYGLDRAGVRLDDRQAIA
MAB_0894c|M.abscessus_ATCC_199 ----VIVTLEG-GQTLTADVLLVAVGRQPQSQ--ALADAGIDVD-RGFVR
* *: . . *.* :: *:* *: : .* .*: : :
Mb0471|M.bovis_AF2122/97 VDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDH
Rv0462|M.tuberculosis_H37Rv VDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDH
MMAR_0785|M.marinum_M IGEYMQTSVGHIYAIGDVTGQLMLAHVAEAMGVVAAETIAGAETLSLGDY
MUL_2214|M.ulcerans_Agy99 IGEYMQTSVGHIYAIGDVTGQLMLAHVAEAMGVVAAETIAGAETLPLGDY
MAV_4687|M.avium_104 ITDYMRTNIEHIYAIGDVTGKLQLAHVAEAQGVVAAETIAGAETLALGDY
MLBr_02387|M.leprae_Br4923 IDDYMQTNVSHIYAIGDVTGKLQLAHVAEAQGVVAAEAIAGAETLALSDY
Mflv_0114|M.gilvum_PYR-GCK IDDYMRTNVPHIYAIGDVTAKLQLAHVAEAMGVVAAETIAGADTLPFEDY
Mvan_0794|M.vanbaalenii_PYR-1 IDDYMRTNVQHIYAIGDVTAKLQLAHVAEAMGVVAAETIAGAETLALGDY
MSMEG_0903|M.smegmatis_MC2_155 IDDYMRTNVGHIYAIGDVTGKLQLAHVAEAMAVVAAETIAGAETLPLGDY
TH_4200|M.thermoresistible__bu IDDYMRTSVPHIYAIGDVTAKLQLAHVAEAMGVVAAETIAGVETLPLGDY
MAB_0894c|M.abscessus_ATCC_199 VDDRLATNHAGVYAVGDLVAGQQLAHRGFAHGILVAEVIAKGDPVPVAEH
: : : *. :**:**: . *** . * .::.**.** :.:.. ::
Mb0471|M.bovis_AF2122/97 RMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPS
Rv0462|M.tuberculosis_H37Rv RMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPS
MMAR_0785|M.marinum_M RMLPRATFCQPQVASFGLTEQQARDEGYDVKVAKFPFTANGKAHGLGDPS
MUL_2214|M.ulcerans_Agy99 RMLPRATFCQPQVASFGLTEQQARDEGYDVKVAKFPFTANGKAHGLGDPS
MAV_4687|M.avium_104 RMMPRATFCQPNVASFGLTEQQARDEGHDVVVAKFPFTANGKAHGVGDPS
MLBr_02387|M.leprae_Br4923 RMMPRATFCQPNVASFGLTEQQARDGGYDVVVAKFPFTANAKAHGMGDPS
Mflv_0114|M.gilvum_PYR-GCK RMMPRATFCQPQVASFGLTEQQAKDEGYDVVVAKFPFTANGKAHGLGDPT
Mvan_0794|M.vanbaalenii_PYR-1 RMLPRATFCQPQVASFGLTEQQAKDEGYDVVVAKFPFTANGKAHGLGDPT
MSMEG_0903|M.smegmatis_MC2_155 RMMPRATFCQPQVASFGLTEEQARDEGYDVKVAKFPFTANGKAHGLADPT
TH_4200|M.thermoresistible__bu RMMPRATFCQPQVASFGLTEEQAREEGYDVKVAKFPFTANGKAHGMGAPS
MAB_0894c|M.abscessus_ATCC_199 -LIPRVTYSHPEVASVGLTEAAAREEYGEITTTVYDLAGNGKSQILRTSG
::**.*:.:*:***.**** *:: :: .: : ::.*.*:: : .
Mb0471|M.bovis_AF2122/97 GFVKLVADAKHG--ELLGGHLVGHDVAELLPELTLAQRWDLTASELARNV
Rv0462|M.tuberculosis_H37Rv GFVKLVADAKHG--ELLGGHLVGHDVAELLPELTLAQRWDLTASELARNV
MMAR_0785|M.marinum_M GFVKLVADGKHG--ELLGGHLVGHDVSELLPELTLAQKWDLTATELARNV
MUL_2214|M.ulcerans_Agy99 GFVKLVADGKHG--ELLGGHLVGHDVSELLPELTLAQKWDLTATELARNV
MAV_4687|M.avium_104 GFVKLIADAKYG--ELLGGHLVGHDVSELLPELTLAQKWDLTATELARNV
MLBr_02387|M.leprae_Br4923 GFVKLVADAKYG--ELLGGHMIGHNVSELLPELTLAQKWDLTATELVRNV
Mflv_0114|M.gilvum_PYR-GCK GFVKLIADKKHL--ELLGGHLIGPDVAELLPELTLAQKWDLTANELARNV
Mvan_0794|M.vanbaalenii_PYR-1 GFVKLVADRKHL--ELLGGHLIGPDVSELLPELTLAQKWDLTANELARNV
MSMEG_0903|M.smegmatis_MC2_155 GFVKLIADAKYG--ELLGGHLIGPDVSELLPELTLAQKWDLTVNELARNV
TH_4200|M.thermoresistible__bu GFVKLIADAKYG--ELLGGHMVGHDVSELLPELTLAQKWDLTAHELARNV
MAB_0894c|M.abscessus_ATCC_199 GIKVIRRGPADGDGAIVGIHCVGDRVGELIGEAQLMVGWEALPTEVRPFM
*: : . ::* * :* *.**: * * *: *: :
Mb0471|M.bovis_AF2122/97 HTHPTMSEALQECFHGLVGHMINF--
Rv0462|M.tuberculosis_H37Rv HTHPTMSEALQECFHGLVGHMINF--
MMAR_0785|M.marinum_M HTHPTMSEALQECFHGLAGHMINF--
MUL_2214|M.ulcerans_Agy99 HTHPTMSEALQECFHGLAGHMINF--
MAV_4687|M.avium_104 HTHPTMSEALQECFHGLTGHMINF--
MLBr_02387|M.leprae_Br4923 HTHPTLSEALQECFHGLIGHMINF--
Mflv_0114|M.gilvum_PYR-GCK HTHPTLSEAMQECFHGLVGHMINF--
Mvan_0794|M.vanbaalenii_PYR-1 HTHPTLSEAMQECFHGLVGHMINF--
MSMEG_0903|M.smegmatis_MC2_155 HTHPTLSEALQECFHGLAGHMINF--
TH_4200|M.thermoresistible__bu HTHPTLSEAMQECFHGLVGHMINF--
MAB_0894c|M.abscessus_ATCC_199 HAHPTQNEALGEALLALAGTPLHKHS
*:*** .**: *.: .* * ::