For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. thermoresistible (build 8) | TH_4494 | - | - | 100% (934) | cation-transporting ATPase Pma1 |
M. thermoresistible (build 8) | TH_2842 | - | e-169 | 39.69% (960) | PUTATIVE ATPase, P-type (transporting), HAD superfamily, |
M. thermoresistible (build 8) | TH_2876 | - | 3e-75 | 29.83% (761) | PUTATIVE ATPase, P-type (transporting), HAD superfamily, |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2020 | ctpF | 0.0 | 44.91% (904) | metal cation transporter P-type ATPase A CtpF |
M. gilvum PYR-GCK | Mflv_0956 | - | 1e-162 | 39.91% (912) | ATPase, P-type (transporting), HAD superfamily, subfamily IC |
M. tuberculosis H37Rv | Rv1997 | ctpF | 0.0 | 44.91% (904) | metal cation transporter P-type ATPase A CtpF |
M. leprae Br4923 | MLBr_02671 | - | 2e-92 | 30.14% (929) | putative cation transport ATPase |
M. abscessus ATCC 19977 | MAB_0962 | - | 2e-50 | 25.25% (816) | cation-transporting ATPase E |
M. marinum M | MMAR_0860 | ctpF | 0.0 | 46.99% (896) | metal cation-transporting p-type ATPase F, CtpF |
M. avium 104 | MAV_5219 | - | 2e-92 | 30.55% (933) | ATPase, P-type (transporting), HAD superfamily protein, subfamily |
M. smegmatis MC2 155 | MSMEG_3926 | - | 0.0 | 68.53% (896) | cation-transporting ATPase Pma1 |
M. ulcerans Agy99 | MUL_0612 | ctpF | 0.0 | 46.54% (896) | metal cation-transporting p-type ATPase F, CtpF |
M. vanbaalenii PYR-1 | Mvan_1648 | - | 0.0 | 68.42% (896) | ATPase, P-type (transporting), HAD superfamily, subfamily IC |
CLUSTAL 2.0.9 multiple sequence alignment MLBr_02671|M.leprae_Br4923 MKIPHVTDPVSNMVGGMAQVVRASTHAATGAVNTMQMLASPVAEFAWPVV MAV_5219|M.avium_104 -------------------MVRAGVSTAAGAAGALQTLASPVAELAGPVI Mb2020|M.bovis_AF2122/97 -------------------------------------------------- Rv1997|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0860|M.marinum_M -------------------------------------------------- MUL_0612|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1648|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4494|M.thermoresistible__bu -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02671|M.leprae_Br4923 QSVAKSTGRALGTGHSPNFANRVDPPVRWHNGQRVHLDLDPLLPFPRWHE MAV_5219|M.avium_104 QSMAQTTGRAIGLDGSADGAPAIVPPVRWHSGRRVHLDLDPLLPFPRWHE Mb2020|M.bovis_AF2122/97 -------------------------------------------------- Rv1997|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0860|M.marinum_M -------------------------------------------------- MUL_0612|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1648|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4494|M.thermoresistible__bu -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02671|M.leprae_Br4923 YAAVVEEPVRRIPGVAKGHVEGSLGRLVIELDKNADSDVVLGKVRDVVIA MAV_5219|M.avium_104 YAPAVEEPVRRIPGVAKAHVEGSLGRLVVELADDADNAAVLDEVRSTVAS Mb2020|M.bovis_AF2122/97 -------------------------------------------------- Rv1997|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0860|M.marinum_M -------------------------------------------------- MUL_0612|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1648|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4494|M.thermoresistible__bu -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02671|M.leprae_Br4923 LAADLALTGARSAPKVAPFADPGNPLAILMPLTAAVMDLVALSAAVTGWV MAV_5219|M.avium_104 VAADISWSKAEAAPPSAPFADPGNPLAILVPLTAAALDLVAMGAAVTGWV Mb2020|M.bovis_AF2122/97 -------------------------------------------------- Rv1997|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0860|M.marinum_M -------------------------------------------------- MUL_0612|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1648|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4494|M.thermoresistible__bu -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02671|M.leprae_Br4923 TRLPAVPQTIRAAAALVNHQPRMVSLLESRLGRVGTDIALSITTAAASGL MAV_5219|M.avium_104 TRLPAAPQTTRAAAALINHQPRMVSILEARLGRVGTDIALAATTAAAHGL Mb2020|M.bovis_AF2122/97 -------------------------------------------------- Rv1997|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0860|M.marinum_M -------------------------------------------------- MUL_0612|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1648|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4494|M.thermoresistible__bu -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02671|M.leprae_Br4923 TQAVGTPLLDLACRGLQLSEAAAHQRVWRDREPQLASPKRPQAPVVPVIS MAV_5219|M.avium_104 TQSFGTPLLDLTQRTLQISEAAAHRRVWRDREPQLASPDRPQAPVVPVIS Mb2020|M.bovis_AF2122/97 -------------------------------------------------- Rv1997|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0860|M.marinum_M -------------------------------------------------- MUL_0612|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1648|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4494|M.thermoresistible__bu -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02671|M.leprae_Br4923 SAGEKSHAAGHNWTAAASNEASHLVVGGSIDAAIDTAKGSMKGPVESYVD MAV_5219|M.avium_104 SA--KSEVPRHSWAAAAAGEASHVVVGGTIDAAMDKAKGSMAGPVESYVD Mb2020|M.bovis_AF2122/97 -------------------------------------------------- Rv1997|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0860|M.marinum_M -------------------------------------------------- MUL_0612|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1648|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4494|M.thermoresistible__bu -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02671|M.leprae_Br4923 SAANGSLIAAASALLAGGGTEDAAGAILAGVPRAAHMGQQAFAATLGRGL MAV_5219|M.avium_104 SAANGSLIAAVSALVAGGGTEDAAAAIEAGVPRAAHMGRQAFAAVLGRGL Mb2020|M.bovis_AF2122/97 -------------------------------------------------- Rv1997|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0860|M.marinum_M -------------------------------------------------- MUL_0612|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1648|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4494|M.thermoresistible__bu -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02671|M.leprae_Br4923 ANAGQLVLDPGALRRLDQVKVVVIDGAALRGDHRAVLLARGNTPGWDDDR MAV_5219|M.avium_104 ANSGQLVLDPGALRRLDRVKVVVIDGAALRGDHRAVLRVRGEAPGWDDDR Mb2020|M.bovis_AF2122/97 -------------------------------------------------- Rv1997|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0860|M.marinum_M -------------------------------------------------- MUL_0612|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1648|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4494|M.thermoresistible__bu -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02671|M.leprae_Br4923 VYEVTDALLHGERAPEPDPDESPATGARLRWVPLQGPSATPVQGREHADL MAV_5219|M.avium_104 VYEVADALLHGEEAPEPDPDELPATGARLRWVPSQGPSAMPAQGLESADL Mb2020|M.bovis_AF2122/97 -------------------------------------------------- Rv1997|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0860|M.marinum_M -------------------------------------------------- MUL_0612|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1648|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4494|M.thermoresistible__bu -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02671|M.leprae_Br4923 VVNGECVGGVDVGWEVDPYAIPLLQTAHRTGARVVLRHVAGTEDLSASVG MAV_5219|M.avium_104 IVDGDRVGRVDVGWEVDPYAIPLFQTAHRTGARVVLRHVAGTEDLTASVG Mb2020|M.bovis_AF2122/97 -------------------------------------------------- Rv1997|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0860|M.marinum_M -------------------------------------------------- MUL_0612|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1648|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4494|M.thermoresistible__bu -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02671|M.leprae_Br4923 ATHPPGTPLLKLVRELRTDRGPVLLITAVHRDFASTDTLAALAIADVGVA MAV_5219|M.avium_104 ATHPPGTPLLNVVRELRADRGPVLLITALHRDFASTDTLAALAIADVGVA Mb2020|M.bovis_AF2122/97 -------------------------------------------------- Rv1997|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0860|M.marinum_M -------------------------------------------------- MUL_0612|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1648|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4494|M.thermoresistible__bu -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02671|M.leprae_Br4923 LDDPHAATPWTADIITGTDLAAAVRILSALPVARSASESSVHLAQGGTTL MAV_5219|M.avium_104 LDDPRAATAWTADIITGTDLADAVRILSAIPVARSASESAVHLAQGGTTL Mb2020|M.bovis_AF2122/97 -------------------------------------------------- Rv1997|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_0860|M.marinum_M -------------------------------------------------- MUL_0612|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1648|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_4494|M.thermoresistible__bu -------------------------------------------------- Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02671|M.leprae_Br4923 AGLLLITASAGSKSASPITLRRWFSPVNAAAATALVTGVVSASKVLRLPD MAV_5219|M.avium_104 AGLLLVTGEQ-EKGASPVSFRRWLNPVNAAAATALVAGTFSATRVLRLPD Mb2020|M.bovis_AF2122/97 ------------------------------------------------MS Rv1997|M.tuberculosis_H37Rv ------------------------------------------------MS MMAR_0860|M.marinum_M ------------------------------------------------MS MUL_0612|M.ulcerans_Agy99 ------------------------------------------------MS MSMEG_3926|M.smegmatis_MC2_155 -------------------------------------------MRRPADA Mvan_1648|M.vanbaalenii_PYR-1 -----------------------MTLPCGQWQEEHAGMGAIFSAARSRET TH_4494|M.thermoresistible__bu -------------------------LTLSSITRRREGVVMDAQSVAADLP Mflv_0956|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0962|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_02671|M.leprae_Br4923 PTPQPLTAWHALDPEIVYSRLAGVTQPLAVEPGTPDWRRRLDDLSYTRAL MAV_5219|M.avium_104 PTPQPLTAWHALDPEIVYSRLAGGARPLAVET-EPSWRRRLDDLSYSPAL Mb2020|M.bovis_AF2122/97 ASVSATTAHHGLPAHEVVLLLESDPYHGLSDGEAAQRLERFG-------- Rv1997|M.tuberculosis_H37Rv ASVSATTAHHGLPAHEVVLLLESDPYHGLSDGEAAQRLERFG-------- MMAR_0860|M.marinum_M VTVTATAAHHGLPAHEVVLLLETDPHLGLSDDEAAERLQRFG-------- MUL_0612|M.ulcerans_Agy99 VSVTATAAHHGLPAHEVVLLLETDPHRGLSDGEAAERLQRFG-------- MSMEG_3926|M.smegmatis_MC2_155 GGNSNENNWHTMQPDEVLDALGAS-RSGLTDSEVERRRAVHG-------- Mvan_1648|M.vanbaalenii_PYR-1 EPVPAEVAWHTLAVEDAVRRLDAD-LDGLTDGEVQRRRADFG-------- TH_4494|M.thermoresistible__bu PAIDFDRPWHALSTDAVLAELGCD-ADGLTDEQARRRRARYG-------- Mflv_0956|M.gilvum_PYR-GCK -----MSDWHARSVREVTDALDTDVTAGLTSEAAEERRHRHG-------- MAB_0962|M.abscessus_ATCC_1997 --------MATIEGLTISGLTAAEVAERVAQGKTNDVPSRAAR------- . MLBr_02671|M.leprae_Br4923 SPLRKPVTKLARLASATRQEFADPLTPILAVGAAASAIVG-SNIDALLVA MAV_5219|M.avium_104 APLRAPLQNVLRLASATRTELADPLTPILAVGAAASAIVG-SNIDALLVA Mb2020|M.bovis_AF2122/97 -PNTLAVVTRASLLARILRQFHHPLIYVLLVAGTITAGLK-EFVDAAVIF Rv1997|M.tuberculosis_H37Rv -PNTLAVVTRASLLARILRQFHHPLIYVLLVAGTITAGLK-EFVDAAVIF MMAR_0860|M.marinum_M -PNALPLAKRGGLLLRILRQFHHPLIYVLLVAGAITAGLQ-EYIDSSVIF MUL_0612|M.ulcerans_Agy99 -PNALPLAKRGGLLLRILRQFHHPLIYVLLVAGAITAGLQ-EYIDSSVIF MSMEG_3926|M.smegmatis_MC2_155 -WNRLAAVRKQSALVPFIRQFHNVLIYVMSCAAIVTAVLQ-HWVDAAVLF Mvan_1648|M.vanbaalenii_PYR-1 -WNRLEVAKPQSAVWRLLRQFHNVLIYLMCAAAAVTAVLE-HWIDTIVLL TH_4494|M.thermoresistible__bu -PNQLTASRKTHPVVRFIKQFHNVLLYIMTIAAVITAFLG-HWVDTGVLL Mflv_0956|M.gilvum_PYR-GCK -PNQLTEAAAVPVWRKVLRLLADKMTLVLLVAAAVSAVVSREWETPVVIM MAB_0962|M.abscessus_ATCC_1997 ---SVSDIVRANVFTRINAILGVLLIIVLSTGSIINGAFG---------- : : :: .. .. . MLBr_02671|M.leprae_Br4923 GVMTVNAITGGVQRLRAEAAAAELFAEQDQLVRRVVVPAVATTRRRLEAA MAV_5219|M.avium_104 GVMTVNAITGGAQRLRAESAAAELFAEQDQMVRRVVVPAVATTRRRLEAA Mb2020|M.bovis_AF2122/97 GVVVINAIVGFIQESKAEAALQGLRSMVHTHAK----------------V Rv1997|M.tuberculosis_H37Rv GVVVINAIVGFIQESKAEAALQGLRSMVHTHAK----------------V MMAR_0860|M.marinum_M GVVVLNAIVGFIQESKAESALEGLRSMVRTQAT----------------V MUL_0612|M.ulcerans_Agy99 GVVVLNAIVGFIQESKAESALEGLRSMVRTQAT----------------V MSMEG_3926|M.smegmatis_MC2_155 AAVLINVVIAYVQEGRAQAALDAIRAMMSPHAT----------------V Mvan_1648|M.vanbaalenii_PYR-1 AAVVINVVIAYIQEGKAEAAMDAIRAMLSPHAT----------------V TH_4494|M.thermoresistible__bu GAVIVNAVIAFVQEGKAESALDAIRALLSPRAT----------------V Mflv_0956|M.gilvum_PYR-GCK LVVTLNTVLNYVQEARAENSLQALRDMSISYSR----------------V MAB_0962|M.abscessus_ATCC_1997 LLIIANSAVGIIQELRAKQILDKLAIVGQTRPL----------------V : * *. :*: : . MLBr_02671|M.leprae_Br4923 QHATRTVTVSAKSLRAGDVIDLAAPEVVPADARVLVAEDLEVDESLLTGE MAV_5219|M.avium_104 RHATRTATVSAKSLRPGDVIDLAAPEVVPADARLLEAEDLEVDESLLTGE Mb2020|M.bovis_AF2122/97 VREGHEHTMPSEELVPGDLVLLAAGDKVPADLRLVRQTGLSVNESALTGE Rv1997|M.tuberculosis_H37Rv VREGHEHTMPSEELVPGDLVLLAAGDKVPADLRLVRQTGLSVNESALTGE MMAR_0860|M.marinum_M IRDGHEHTVASEDLVPGDLVLLESGDKVPADLRLVRATELHLNESALTGE MUL_0612|M.ulcerans_Agy99 IRDGHEHTVASEDLVTGDLVLLESGDKVPADLRLVRATELHLNESALTGE MSMEG_3926|M.smegmatis_MC2_155 TRNGRTLDVEAVELVPGDVVQLAAGDRIPADLRLIGVDGLQVDEAPLTGE Mvan_1648|M.vanbaalenii_PYR-1 IRDGRVVDVDAAELVPGDLVKLAPGDRVPADLRLTGVDGLRVEEAMLTGE TH_4494|M.thermoresistible__bu IRGGRPVDIDAVDVVPGDVVRLVSGDRVPADVRLLTADGLLADESALTGE Mflv_0956|M.gilvum_PYR-GCK RRDGGEHRLPRTELVPGDVVLLEAGDAVPADGRIVSAARLQVAESALTGE MAB_0962|M.abscessus_ATCC_1997 RRDGAATALAPNEVVLDDIIELGPGDQIVVDGEVIEESALEIDESLLTGE : : .: .*:: * . : : .* .: * *: **** MLBr_02671|M.leprae_Br4923 SLPVDKRVDPVAI---NDADRASMLFEGSAIVAGHARAIVVATGVGTAAH MAV_5219|M.avium_104 SLPVDKQVEPVAV---NDPDRASMLFEGSTIVAGHARAIVVATGVGTAAH Mb2020|M.bovis_AF2122/97 STPVHKDEVALPE-GTPVADRRNIAYSGTLVTAGHGAGIVVATGAETELG Rv1997|M.tuberculosis_H37Rv STPVHKDEVALPE-GTPVADRRNIAYSGTLVTAGHGAGIVVATGAETELG MMAR_0860|M.marinum_M SAAVHKSVAVLPE-ATPVADRLNMVYSGTLVTAGRGAGIAVATGAETELG MUL_0612|M.ulcerans_Agy99 SAAVHKSVAVLPE-ATPVADRLNMVYSGTLVTAGRGAGIAVATGAETELG MSMEG_3926|M.smegmatis_MC2_155 SAPVWKTIGVDDE-DTSLPDRRSMAYSGTLAIHGQATGVVVGTGAQTELG Mvan_1648|M.vanbaalenii_PYR-1 SVPVDKACDPVGA-ESPIAERVGMAYSGTLVVHGQGTGVVVGTGAHTELG TH_4494|M.thermoresistible__bu SVPVEKTPAAVGA-DAPVGDRVGMAYSGTVIVHGQGTGVVVGTGTATELG Mflv_0956|M.gilvum_PYR-GCK SAPVDKAVDGLDDTDLPLGDRTNMLYMNTEVTRGRATMVVTATGMDTEVG MAB_0962|M.abscessus_ATCC_1997 ADAIEKTIG-------------SQVLSGSFVVAGSGAYRATKVGREAYAA : .: * . .: * . .. .* : MLBr_02671|M.leprae_Br4923 RAISAVADVEVSAG-VQARLRELTSKVLPLTLAGGAAVTGLALLRR-ASL MAV_5219|M.avium_104 RAISAVADVETAAG-VQARLRELTSKVLPLTLAGGAAVSTLALLRR-ASL Mb2020|M.bovis_AF2122/97 EIHRLVGAAEVVATPLTAKLAWFSKFLTIAILGLAALTFGVGLLRR-QDA Rv1997|M.tuberculosis_H37Rv EIHRLVGAAEVVATPLTAKLAWFSKFLTIAILGLAALTFGVGLLRR-QDA MMAR_0860|M.marinum_M EIHRLVGAAETLMTPLTAKLAWFSKVLTIAILGLAAVTFAVGLLRQ-QDA MUL_0612|M.ulcerans_Agy99 EIHRLVGAAETLMTPLTAKLAWFSKVLTIAILGLAAVTFAVGLLRL-QDA MSMEG_3926|M.smegmatis_MC2_155 RINHLLTGVAPTATPLLRQISRFGRVLAVVILLLSAATYALGVIWRGETL Mvan_1648|M.vanbaalenii_PYR-1 QIDRLLTGISSSATPLLRQISRFGRILAAVIVALSAATYAVGVLWRGQTV TH_4494|M.thermoresistible__bu RINRMLADIAATETRMQRQIARFAKALAAVILLASAATYVLGVLVRGHDP Mflv_0956|M.gilvum_PYR-GCK AIATMLGTAGVSRTPLQQRIDNLAQMLTVVALLVVIVVTVLGLLRG-DTW MAB_0962|M.abscessus_ATCC_1997 KLAEEASKFTLVHSELRNGINKILQFITYLLLPAGALIIYTQLFTTDDSW : : : : : :: MLBr_02671|M.leprae_Br4923 RQAVADGVAIAVAAVPEGLPLVATLSQLAAAQRLTAKGALVRSPRTIEAL MAV_5219|M.avium_104 RQAVADGVAIAVAAVPEGLPLVATLSQLSAAQRLTARGALVRAPRTIEAL Mb2020|M.bovis_AF2122/97 VETFTAAIALAVGAIPEGLPTAVTITLAIGMARMAKRRAVIRRLPAVETL Rv1997|M.tuberculosis_H37Rv VETFTAAIALAVGAIPEGLPTAVTITLAIGMARMAKRRAVIRRLPAVETL MMAR_0860|M.marinum_M VETFTAAIALAVGAIPEGLPAAVTITLAIGVARMARRRAVVRRLPTVETL MUL_0612|M.ulcerans_Agy99 VETFTAAIALAVGAIPEGLPAAVTIILAIGVARMARRRAVVRHLPTVETL MSMEG_3926|M.smegmatis_MC2_155 TEMFMMTVALAASAIPEGLPAIMTVTLAIGVQRMSRRRAIVCRLPAVEAL Mvan_1648|M.vanbaalenii_PYR-1 SEMFMMAVALAASAIPEGLPAIMTVTLAIGVQRMSRRNAIVRRLPAVEAL TH_4494|M.thermoresistible__bu SEMFMMVVALTASAIPEGLPAILTVTMAIGVQKMSRRNAIVRRLPAVETL Mflv_0956|M.gilvum_PYR-GCK TELLLTAVSLAVATIPEGLTAVVAFTLAMGASRLARRGAIIKQLSAVETL MAB_0962|M.abscessus_ATCC_1997 QESVLRMVGALVPMVPEGLVLMTSIAFAVGVIRLGRRQCLVQELPAIEGL : . :. . :**** :. . :: : .:: ::* * MLBr_02671|M.leprae_Br4923 GRVDTICFDKTGTLTENRLRVVCAVP----------------------NT MAV_5219|M.avium_104 GRVDTICFDKTGTLTENRLRVVCAVP----------------------DD Mb2020|M.bovis_AF2122/97 GSTTVICADKTGTLTENQMTVQSIWTPHGEIRATGTGYAPDVLLCDTDDA Rv1997|M.tuberculosis_H37Rv GSTTVICADKTGTLTENQMTVQSIWTPHGEIRATGTGYAPDVLLCDTDDA MMAR_0860|M.marinum_M GSTTVICTDKTGTLTENQMTVQVIWTPDAVVEVTGTGYAPDGILQDCDGV MUL_0612|M.ulcerans_Agy99 GSTTVICTDKTGTLTENQMTVEVIWTPDDVVEVTGTGYAPDGILQDCDGA MSMEG_3926|M.smegmatis_MC2_155 GSVTVICTDKTGTLTSNEMTVQRVVCGGHDIDVGGVGYAPVGDFS-IDGR Mvan_1648|M.vanbaalenii_PYR-1 GSVTVICSDKTGTLTSNEMTVQRIVCAGHTIDVGGVGYAPVGDLS-IDGR TH_4494|M.thermoresistible__bu GSVTVICSDKTGTLTTNEMTVQRVLCGGHEFDVGGVGYTPVGDVT-VDGR Mflv_0956|M.gilvum_PYR-GCK GSTADIATDKTGTLTLNEMTVRRLLLPGREFRVSGEGYSTDGKILVSDGR MAB_0962|M.abscessus_ATCC_1997 ARVDTVCADKTGTLTENGMRLADVHFPDRD-------------------- . . :. ******* * : : MLBr_02671|M.leprae_Br4923 RMPHDPLPDITDPHSAAVLRDAARASTQPHDGQGHTHATDEAILTAASSL MAV_5219|M.avium_104 VNPHDPFPELTAPQSAELVRAAARASARPQEGQGHAHATDEAILTAASSL Mb2020|M.bovis_AF2122/97 PVPVNANAALRWSLLAGACSNDAALVRDGTRWQIVGDPTEGAMLVVAAKA Rv1997|M.tuberculosis_H37Rv PVPVNANAALRWSLLAGACSNDAALVRDGTRWQIVGDPTEGAMLVVAAKA MMAR_0860|M.marinum_M PMSMDANAALRWSLIAGASCNDAALTHDDARWDIVGDPTEGAMLVVASKA MUL_0612|M.ulcerans_Agy99 PMSMDANAALRWSLIAGASCNDAALTHDDARWDIVGDPTEGAMLVVASKA MSMEG_3926|M.smegmatis_MC2_155 VIDPSRYPALMEALLAASLCNDASLDVEDEVWVITGDPTEAALLVVAKKA Mvan_1648|M.vanbaalenii_PYR-1 TVDASRNPALLDALRVGVLCNDAALHEVDGAWTIAGDPTEAALLVVAAKA TH_4494|M.thermoresistible__bu VVDPGRYPALVALVRAGVLCNDSRLHREGEDWTISGDPTEAALLVLGHKL Mflv_0956|M.gilvum_PYR-GCK PLP-----DLTAPLLAMALCSDASVREG----SLVGDPTEGALVVLAEKG MAB_0962|M.abscessus_ATCC_1997 --------------------GDEDALAVLAQLAADDPRPNASIAAIAEAY .: :: . . MLBr_02671|M.leprae_Br4923 NSHTD---STWSLIAEVPFESSRGYAAAIGITGNGK-----APMLMLKGA MAV_5219|M.avium_104 NGQRD---SDWSMIAEVPFESSRGFAAAIGTVGNANGNPSDTPVLILKGA Mb2020|M.bovis_AF2122/97 GFNPERLATTLPQVAAIPFSSERQYMATLHRDGTD-------HVVLAKGA Rv1997|M.tuberculosis_H37Rv GFNPERLATTLPQVAAIPFSSERQYMATLHRDGTD-------HVVLAKGA MMAR_0860|M.marinum_M GLDLGRLASGMPREAAIPFSSERQYMATLHRDGAD-------RVVLAKGA MUL_0612|M.ulcerans_Agy99 GLDLGRLASGMPREAAIPFSSERQYMATLHRDGAD-------RVVLAKGA MSMEG_3926|M.smegmatis_MC2_155 GLDHDRETVSHPRVATVPFASENRIMGTLHSDVDR------TPLIVVKGA Mvan_1648|M.vanbaalenii_PYR-1 DLLRDRLQAEFPRSATLPFASENRIMATLHIIRGG------DALILVKGA TH_4494|M.thermoresistible__bu GLIHDELESRWPRVDSVPFESELRMMGTLHVDKEAGA--DAEPLVLVKGA Mflv_0956|M.gilvum_PYR-GCK GVDVTGARAAIPRLAEVPFDSEYKYMATFCARSDLDG--SGGHRCFVKGA MAB_0962|M.abscessus_ATCC_1997 DTPPG-----WETTAIAPFSSAKKWSGASYGEHGN----------WVIGA . ** * .: ** MLBr_02671|M.leprae_Br4923 PEKILPRCRFADPEADVA---------HAESLVRHLAEQGLRVLAVAQCS MAV_5219|M.avium_104 PEVILPRCRFADPEADQQ---------RAEAVVRGLAEQGLRVLAVAQRG Mb2020|M.bovis_AF2122/97 VERMLDLCGTEMGADGALRPLDRATVLRA---TEMLTSRGLRVLATGMGA Rv1997|M.tuberculosis_H37Rv VERMLDLCGTEMGADGALRPLDRATVLRA---TEMLTSRGLRVLATGMGA MMAR_0860|M.marinum_M VERVLELCSSQMGADGALRPLEPGAVVDA---AEMLTARGLRVLATAVRV MUL_0612|M.ulcerans_Agy99 VERVLELCSSQMGADGALRPLEPGAVVDA---AEMLTARGLRVLATAVRV MSMEG_3926|M.smegmatis_MC2_155 PERVLDICDSQRSPHGEE-PLDRLYWQRM---AATTAAQGLRVLAIARRC Mvan_1648|M.vanbaalenii_PYR-1 PERVVDMCRWQRGNDGEH-VIDREHWRQM---AAETAAQGLRVLALAQRR TH_4494|M.thermoresistible__bu PERVVELCDRQLDSRGEQ-PVDPAYWHRV---AAETADRGLRVLALAQRR Mflv_0956|M.gilvum_PYR-GCK PGVLLEHAGSVLGEDGPR-PIDPGYRQRIRERVEQLASEGLRTLMIAGRD MAB_0962|M.abscessus_ATCC_1997 PDVLLDPADAIATA------------------AEEIGARGLRVLLLASAE :: . . .***.* . MLBr_02671|M.leprae_Br4923 WGHDTTDDNDTDADAVDAAAHDLELVGYIGLADTARPSSRPLIEALVTAG MAV_5219|M.avium_104 WKHDTDDD-DTDADAVDAAAHNLELLGYVGLADTARASARPLIEALLDAE Mb2020|M.bovis_AF2122/97 GAG-----TPDDFD-ENVIPGSLALTGLQAMSDPPRAAAASAVAACHSAG Rv1997|M.tuberculosis_H37Rv GAG-----TPDDFD-ENVIPGSLALTGLQAMSDPPRAAAASAVAACHSAG MMAR_0860|M.marinum_M G-G-----SPLELN-EDTLPGDLAFTGLHAMLDPPRGAARRAVAACHTAG MUL_0612|M.ulcerans_Agy99 G-G-----SPLELN-EDTLPGDLAFTGLHAMVDPPRGAARCAVAACHTAG MSMEG_3926|M.smegmatis_MC2_155 GAPR----NAGTLD-IADLDSGFTMLGLVGIIDALRPEVAAAVRECHRAG Mvan_1648|M.vanbaalenii_PYR-1 GTP------DETLE-IGDLGDGFTMLALVGIIDPLRPEAVAAVQECHRAG TH_4494|M.thermoresistible__bu GHPQ----TPGALT-LADLEGGFTLLGLVGIIDPLRPEAITAVRECHRAG Mflv_0956|M.gilvum_PYR-GCK IDHD----LPADPDGLQTLVDDLTVYAVVGIVDPPRPEAGEAIATAHAAG MAB_0962|M.abscessus_ATCC_1997 LSVD-----------DAHAPGAVTPRALVVLEQKIRPDARETLDYFASQH . . : : * : MLBr_02671|M.leprae_Br4923 RNVVLITGDHPITARAIAQQLGLRSD-----ARVVNGTELIGLDEDACAE MAV_5219|M.avium_104 RDVVLITGDHPITARAIARQLGLPAD-----ARVVTGAELAGLDEDACAK Mb2020|M.bovis_AF2122/97 IAVKMITGDHAGTATAIATEVGLLDNTEPAAGSVLTGAELAALSADQYPE Rv1997|M.tuberculosis_H37Rv IAVKMITGDHAGTATAIATEVGLLDNTEPAAGSVLTGAELAALSADQYPE MMAR_0860|M.marinum_M IDVKMITGDHAGTATAIAAQVGLLDDGGPGPGAVLTGPDLAALDAEDYSD MUL_0612|M.ulcerans_Agy99 IDVKMITGDHAGTATAIAAQVGLLDDGGPGPGAVLTGPDLAALDAEDYSD MSMEG_3926|M.smegmatis_MC2_155 IRVKMITGDHAATAREIGAQLGIGIG-----KPAVIGSEIASLNDTDLQT Mvan_1648|M.vanbaalenii_PYR-1 IRVKMITGDHAATAAEIGAQLGIGRD-----GDAVTGAQIAAMDDAALRV TH_4494|M.thermoresistible__bu IRVTMITGDHAGTAREIGAQLGIGGG-----KPAVTGAQIAEIDDADLRV Mflv_0956|M.gilvum_PYR-GCK ITVHMITGDHLSTAAAVAHDLGIPGA-------AASGADLDRLDDDTLRE MAB_0962|M.abscessus_ATCC_1997 VSIKVISGDNAVSVSAVAQTLGLTGA--------AVDARTLPTDTDKLAA : :*:**: :. :. :*: .. . MLBr_02671|M.leprae_Br4923 LAADVQVFARVSPEQKVQIVAALQRCGQVTAMVGDGANDAAAIRMADVGI MAV_5219|M.avium_104 LVADVQVFARVSPEQKVQIVAALQRCGRVTAMVGDGANDAAAIRMADVGI Mb2020|M.bovis_AF2122/97 AVDTASVFARVSPEQKLRLVQALQARGHVVAMTGDGVNDAPALRQANIGV Rv1997|M.tuberculosis_H37Rv AVDTASVFARVSPEQKLRLVQALQARGHVVAMTGDGVNDAPALRQANIGV MMAR_0860|M.marinum_M AVDQATLFARVSPEQKLRLVQALQARGHVVAMTGDGVNDAPALRQASVGV MUL_0612|M.ulcerans_Agy99 AVDQATLFARVSPEQKLRLVQALQARGHVVAMTGDGVNDAPALRQASVGV MSMEG_3926|M.smegmatis_MC2_155 VVQERDIFARASPEHKLRLVRALQAGGEVVAMTGDGVNDSPALKKADVGI Mvan_1648|M.vanbaalenii_PYR-1 VAHERNVFARTSPEHKLRLVRALQATGEVVAMTGDGVNDAPALKKADIGV TH_4494|M.thermoresistible__bu IARDRDVFARASPEHKLRLVRALQAEGEIVAMTGDGVNDAPALKRADIGV Mflv_0956|M.gilvum_PYR-GCK QSPSFGVLARVAPEHKIRLVKALQSRGHVVAMTGDGVNDAPALKQADIGI MAB_0962|M.abscessus_ATCC_1997 TLADATTFGRVRPDQKRAMVKALQSHGHTVAMTGDGVNDVLALKDADIGV :.*. *::* :* *** *. .**.***.** *:: *.:*: MLBr_02671|M.leprae_Br4923 GVSGRGSSAARGAADIVLTDDDLGVLLDALVEGRSMWAGVRDAVTILVGG MAV_5219|M.avium_104 GVSGRGSSAARGAADIVLTDQDLSVLLDALVEGRSMWAGVRDAVTILVGG Mb2020|M.bovis_AF2122/97 AMGRGGTEVAKDAADMVLTDDDFATIEAAVEEGRGVFDNLTKFITWTLPT Rv1997|M.tuberculosis_H37Rv AMGRGGTEVAKDAADMVLTDDDFATIEAAVEEGRGVFDNLTKFITWTLPT MMAR_0860|M.marinum_M AMGRSGTEVAKDAADMVLTDDDFATIEAAVEEGRGVFDNLTKFITWTLPT MUL_0612|M.ulcerans_Agy99 AMGRSGTEVAKDAADMVLTDDDFATIEAAVEEGRGVFDNLTKFITWTLPT MSMEG_3926|M.smegmatis_MC2_155 AMGCRGTEAAKEAADMVLADDNFATIAAAVSEGRTVYDNIRKFVLFMLPT Mvan_1648|M.vanbaalenii_PYR-1 AMGGKGTEAAKESSDIVLADDNFATIAAAVSEGRTVYDNIRKFILFMLPT TH_4494|M.thermoresistible__bu AMGKRGTEAAKESADMVLADDNFATIAAAVAEGRTVYDNIRKFIMFMLPT Mflv_0956|M.gilvum_PYR-GCK AMGITGTDVSKGAANMILTDDNFGTIVAAVREGRGIYANIIKFVKFQLTT MAB_0962|M.abscessus_ATCC_1997 AMG-AGSSASRAVAQIVLLDNKFATLPYVVAEGRRVIGNIERVSNLFLTK .:. *:..:: ::::* *:.:..: .: *** : .: : MLBr_02671|M.leprae_Br4923 NVGEVVFTIIGTVFGAG-RAPVGTRQLLLVNLLTDMFPALSIAVTSQYEE MAV_5219|M.avium_104 NVGEVLFTIIGTAFGAG-RAPVGTRQLLLVNLLTDMFPALAVAVTSQYVE Mb2020|M.bovis_AF2122/97 NLGEGLVILAAIAVGVA--LPILPTQILWINMTTAIALGLMLAFEPKEAG Rv1997|M.tuberculosis_H37Rv NLGEGLVILAAIAVGVA--LPILPTQILWINMTTAIALGLMLAFEPKEAG MMAR_0860|M.marinum_M NIGEGLVILAAIAFGTA--LPILPTQILWINMTTAIALGLMLAFEPKEAA MUL_0612|M.ulcerans_Agy99 NIGEGLVILAAIAFGTA--LPILPTQILWINMTTAIALGLMLAFEPKEAA MSMEG_3926|M.smegmatis_MC2_155 NGGEALVVIAAILFQFT--LPLTPAQVLWINLVTSSTLGLALAFEPPEAG Mvan_1648|M.vanbaalenii_PYR-1 NGGEALVVMAAIVFQIT--LPLTPAQVLWINLATSSTLGLALAFEPREND TH_4494|M.thermoresistible__bu NGGEALVVIAAILFQLT--LPLTPAQVLWINLVTSATLGLALAFEPAERG Mflv_0956|M.gilvum_PYR-GCK AWGFVLIFLVCGSLGLAGGAPFTALQILWVNIIMDGPPALALGVDPTEPD MAB_0962|M.abscessus_ATCC_1997 TVYSVLLALTVGLAGLG-SKIFHYGAVPFPFQPIHVTIAAWFTIGIPAFI :. : . : . . . MLBr_02671|M.leprae_Br4923 PGEDEYQTDEEADEARRTHQHEVLTGPTPSLDAPLMRQIVNRGVVTAAGA MAV_5219|M.avium_104 PDEAEYPSAADAEAARREHRRAVLTGPTPSLDAPLMRQIVTRGAVTAAGA Mb2020|M.bovis_AF2122/97 IMTRPPRDPDQPLLTGWLVRRTLLVSTLLVASAWWLFAWELDNG-----A Rv1997|M.tuberculosis_H37Rv IMTRPPRDPDQPLLTGWLVRRTLLVSTLLVASAWWLFAWELDNG-----A MMAR_0860|M.marinum_M IMSRPPRDPDQPLLTRTLVGRILLVSTLLVASAWWLFEWEVGKG-----A MUL_0612|M.ulcerans_Agy99 IMSRPPRDPDQPLLTRTLVGRILLVSTLLVASAWWLFEWEVGKG-----A MSMEG_3926|M.smegmatis_MC2_155 VMRRKPRAPSESLLSRHFAWRVLLVSVLMAGGALGMFLWELRSG-----T Mvan_1648|M.vanbaalenii_PYR-1 VMSRRPRPPSESLLSRYFMWRVVMVSVLMAGGALTMFLWELRLG-----T TH_4494|M.thermoresistible__bu VMDRKPRPPRESLLSGHFVWRVVLVSVLMAAGALAMFLWELELG-----T Mflv_0956|M.gilvum_PYR-GCK VMHQKPRPPTERLLNRARLQRILVLGMVMTLGTVTVLMLADDLFPESA-G MAB_0962|M.abscessus_ATCC_1997 LSLAPNNERAQTGFVRRVMLSAIPSGLTVGIATFLSYLLARQIL------ : : . : MLBr_02671|M.leprae_Br4923 TTAWAIGRWTPGTERRTATMGLTALVTTQLAQTLLTRRHSPLVVATALGS MAV_5219|M.avium_104 TAAWAIGRWTPGTERRTATMGLTALVTTQLAQTLLTRRHSPLVVATALGS Mb2020|M.bovis_AF2122/97 GLHEARTAALNLFVVVEAFYLFSCRSLTRSAW-RLGMFANRWIILGVSAQ Rv1997|M.tuberculosis_H37Rv GLHEARTAALNLFVVVEAFYLFSCRSLTRSAW-RLGMFANRWIILGVSAQ MMAR_0860|M.marinum_M SVEAARTAALNLFVVVEAFYLFSCRSLTRSAW-RIGFWSNRWIIFGVAAQ MUL_0612|M.ulcerans_Agy99 SVEAARTAALNLFVVVEAFYLFSCRSLTRSAW-RIGFWSNRWIIFGVAAQ MSMEG_3926|M.smegmatis_MC2_155 SVETARTMAVNAIVAAEMFYLLNNRFLLEPVLNRIGLFGNKIAFATVVAC Mvan_1648|M.vanbaalenii_PYR-1 SVETARTMAVNAIVVAEMFYLLNNRFLLEPVLNRIGLFGNKIALATVVAC TH_4494|M.thermoresistible__bu SIETARTMAVNAIVAAEMFYLLNNRYLTEPVLNRAGLLGNRVALATVAAC Mflv_0956|M.gilvum_PYR-GCK DPLFATTLAFTTFVFYQVFNLLNVRSDTGSAFSRQTFT-NGAIWVSLAAV MAB_0962|M.abscessus_ATCC_1997 -------HVSGNSTQASTAALITELVAAVWVLAVVARPYQWWRVALVALS :. . . MLBr_02671|M.leprae_Br4923 AGVLIGIIQTPVISQFFGCTPLGPIAWSGVITATAGATAVSVLAPQWLNK MAV_5219|M.avium_104 AGVLVGIVQTPVLSQFFGCTPLGPVAWTGVLGSTAGATAISALAPNWLAK Mb2020|M.bovis_AF2122/97 AIAQFAITYLPAMNMVFDTAPIDIGVWVRIFAVATAITIVVATDTLLPRI Rv1997|M.tuberculosis_H37Rv AIAQFAITYLPAMNMVFDTAPIDIGVWVRIFAVATAITIVVATDTLLPRI MMAR_0860|M.marinum_M AIAQLAITYLPAMNAVFATAPIGAPVWLRIFGVATVVSLVVAADKLVRRI MUL_0612|M.ulcerans_Agy99 AIAQLAITYLPAMNAVFATAPIGAPVWLRIFGVATVVSLVVAADKLVRRI MSMEG_3926|M.smegmatis_MC2_155 TALQLVFTYAPAMNAVFGSTPLGYVDWIKAAAVGAPVFGVVELEKFMVRR Mvan_1648|M.vanbaalenii_PYR-1 ATLQLAFTYAPPMNAFFGSTPLGHVEWLKAAGVGALVFAVVETEKYMVRR TH_4494|M.thermoresistible__bu VGLTALFTYAPFMNWIFGSAPLGWSDWVKVAAAGALVFVAVEIEKAVMRR Mflv_0956|M.gilvum_PYR-GCK IVLQVLVVQLDVLQNLFDTTELTSAQWLFAIAVGSSVLVVDEIGKAVVRT MAB_0962|M.abscessus_ATCC_1997 GLGYVAIFAIPLARKAFMLDPGNLAVTGPALGIGIAAAAVIEAVWWLQGK . * MLBr_02671|M.leprae_Br4923 AFGIAQLNQE-------------- MAV_5219|M.avium_104 QVAALEPGQQDA------------ Mb2020|M.bovis_AF2122/97 RAQPP------------------- Rv1997|M.tuberculosis_H37Rv RAQPP------------------- MMAR_0860|M.marinum_M APARRR------------------ MUL_0612|M.ulcerans_Agy99 APAQRR------------------ MSMEG_3926|M.smegmatis_MC2_155 RKARAALAGEEPKGGHTAAHR--- Mvan_1648|M.vanbaalenii_PYR-1 LRRTPARQPE------PAA----- TH_4494|M.thermoresistible__bu YRVRPAAVAA-------------- Mflv_0956|M.gilvum_PYR-GCK ARRRRRRRVSGADRPREARPASGR MAB_0962|M.abscessus_ATCC_1997 WSGQPRHFWATGDD----------