For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TTAGHLTHTRHAAPSAPSKSMWTHTGLLIRLALRRDRIRLSIWIAMLSLLMIYTPNALELAYPEEAQRLA RVNLLKTPAGMMMGGPVFGVDETDLGVMMANELMLTLIVATSILAILTVIRHTRAEEESGTAELVLASVV GRYARTTAALSVAAGVNVVLTVTMTAAMVASGFGVSDSLGMCAGVTAVAMVFAAVAAVTAQMWRAARAAT GTAMAALALAALIRGIGDVIDNSGSALSWFSPIAWAQQMRSFVDLRWWPLALLIGLTLALVTLAAALERR REYDDATLSSRGEHPGARPVRGVLALHLVLQRGQTIGWSAGLFIAGLAFGSMTKSLLDAAEGNELIAQMI SAQGTDGVYMTMSQFLAAAASAYVVACVLRLHADERSGLGESVLAGAVSRWRWLSTSVVAAVLGATVLMF FAGLGNGVGAGITLGEPGTVGRLTVAGLAFVPALAVMAGVAAVGVALRQPWIGWLAVASVVLSLYLGALL RLPRWLIDLSPVSRTTVPTDVPVVALVVMCVAAATLTVLAGFLYRRRDAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2196 | - | - | 100% (541) | putative ABC transporter membrane-spanning protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1249c | - | 3e-67 | 33.21% (557) | tetronasin-transport integral membrane protein ABC transporter |
| M. tuberculosis H37Rv | Rv1217c | - | 1e-67 | 33.39% (557) | tetronasin-transport integral membrane protein ABC transporter |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1358c | - | 1e-163 | 56.09% (517) | ABC transporter permease |
| M. marinum M | MMAR_4221 | - | 2e-72 | 34.48% (525) | tetronasin-transport integral membrane protein ABC transporter |
| M. avium 104 | MAV_1361 | - | 3e-67 | 32.54% (547) | ABC transporter membrane-spanning protein |
| M. smegmatis MC2 155 | MSMEG_5076 | - | 0.0 | 69.83% (517) | ABC transporter membrane-spanning protein |
| M. thermoresistible (build 8) | TH_4424 | - | 0.0 | 61.58% (531) | PUTATIVE putative putative ABC transporter membrane-spanning |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_4500 | - | 0.0 | 76.99% (539) | putative ABC transporter membrane-spanning protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2196|M.gilvum_PYR-GCK -MTTAGHLTHTRHAAPSAPSKSMWTHTGLLIRLALRRDRIRLSIWIAMLS
Mvan_4500|M.vanbaalenii_PYR-1 MSTTAGLPTRGRHAAPAARSP--WTGTGDLIGLALRRDRVRLSVWIAALT
MSMEG_5076|M.smegmatis_MC2_155 ----------------------MITGAGALVRLALRRDRVRLAVWIAVLT
TH_4424|M.thermoresistible__bu -MSATVTARHARAARPATGST--LTGLGRLIALALRRDRIRLPVWVVVLT
MAB_1358c|M.abscessus_ATCC_199 -MSTDFATLPIHRPGTDGTPRHPLTGIGTLIMLALRRDRFRICMWVGWLT
Mb1249c|M.bovis_AF2122/97 -MSSTVIDRARPAGHRAPHRGSGFTGTLGLLRLYLRRDRVSLPLWVLLLS
Rv1217c|M.tuberculosis_H37Rv -MSSTVIDRARPAGHRAPHRGSGFTGTLGLLRLYLRRDRVSLPLWVLLLS
MMAR_4221|M.marinum_M -MSTTVLDRPSRPAHRGPQRASGLAGTLRLLRLYLRRDRVGLPLWVMLLS
MAV_1361|M.avium_104 -MSATTLTRPSASASPAPLGGAHFSGTLQMLRLYLRRDRISLPLWVLLLS
: :: * *****. : :*: *:
Mflv_2196|M.gilvum_PYR-GCK LLMIYTPN-ALELAYPEEAQRL-ARVNLLKTPAGMMMGGPVFGVDETDLG
Mvan_4500|M.vanbaalenii_PYR-1 AMTAYAPG-AIKLAYPEEAQRQ-ARVDLLKTPAGMMLGGPMFGGNETDLG
MSMEG_5076|M.smegmatis_MC2_155 STMVYAPN-TIRMTYPDEAQRQ-SRVELLKTPAGMMLGGPMFGVNETDLG
TH_4424|M.thermoresistible__bu VSIGYMPA-ALEMAYPDEVDRL-ARVNLMKNPAGIMFAGPMFGKNETALG
MAB_1358c|M.abscessus_ATCC_199 LLMTYTPL-AFESMYPTTADRM-ARVTMMKTPAGIIMSGPSFGINETDVG
Mb1249c|M.bovis_AF2122/97 VPLATVYIASVETVYPDRSARAAAAAAIMASPAQRALYGPVYNDSLGAVG
Rv1217c|M.tuberculosis_H37Rv VPLATVYIASVETVYPDRSARAAAAAAIMASPAQRALYGPVYNDSLGAVG
MMAR_4221|M.marinum_M VPLATVYVGSIQAVYPDQAARAVAAAAIMASPAQRALYGPVYNDSLGAVG
MAV_1361|M.avium_104 VPLSTVYVGSIEKVYPTAAARAGFAASIMASPAQRALYGKVYSDSLGAVG
:.. ** * . :: .** : * :. . :*
Mflv_2196|M.gilvum_PYR-GCK VMMANELMLTLIVATSILAILTVIRHTRAEEESGTAELVLASVVGRYART
Mvan_4500|M.vanbaalenii_PYR-1 AMMANELMLTMIIATSILAILTVIRHTRAEEESGAAELVLASVVGRYART
MSMEG_5076|M.smegmatis_MC2_155 AMMANELMLTLMVAASILSILTVIRHTRAEEESGAAELVLSSVVGRHART
TH_4424|M.thermoresistible__bu AMVANEAMLTFIVAASILAILTVVRRTRAEEESGTAELVLAAPVGRHART
MAB_1358c|M.abscessus_ATCC_199 VMVANELMTVMIAAAAIMSILTVIRHTRAEEESGAAELVMSAVIGHQART
Mb1249c|M.bovis_AF2122/97 IWKAG----MFHTLIAVAVILTVIRHTRADEESGRAELIDSTVVGRYTNL
Rv1217c|M.tuberculosis_H37Rv IWKAG----MFHTLIAVAVILTVIRHTRADEESGRAELIDSTVVGRYANL
MMAR_4221|M.marinum_M VWKAG----MFHTLIAVAVILTMIRHTRADEETGRAELVESTAVGRYANL
MAV_1361|M.avium_104 IWKAG----MFHVLIAIAVILTVIRHTRADEENGRTELVDSTAIGRYAGL
*. : :: ***::*:***:**.* :**: :: :*: :
Mflv_2196|M.gilvum_PYR-GCK TAALSVAAGVNVVLTVTMTAAMVASGFGVSDSLGMCAGVTAVAMVFAAVA
Mvan_4500|M.vanbaalenii_PYR-1 TAALILVAAVNVVLAVTTTAAMAAGGFGVVDSAAMCVGVTAVAMVFGAVA
MSMEG_5076|M.smegmatis_MC2_155 TAALVLVAGVNVVLAVAMTLAMTVSGFAPADSAAMCFGVSGVAMVFGALA
TH_4424|M.thermoresistible__bu VAAILLLAGVNAVLAVTLTAATAATGLPVVDSAAMSLGITGVAMVFGATA
MAB_1358c|M.abscessus_ATCC_199 YAALIVVALMNAVLAVAMTAALSAADFDFINSLGISLGIIGASMVFAGLG
Mb1249c|M.bovis_AF2122/97 TGALLLSFGASIATGAIGALGLLATDVAPAGSVAFGVALAASGMVFTAVA
Rv1217c|M.tuberculosis_H37Rv TGALLLSFGASIATGAIGALGLLATDVAPAGSVAFGVALAASGMVFTAVA
MMAR_4221|M.marinum_M TAALLLSFGASVATGAIGAAGLLTTDVPAAGSLAFGAALAASGLVFTSVA
MAV_1361|M.avium_104 TAALTLSFAASIATGAIGAAGLLGTDVPAGGSLAFGAALAWSGLVFTAVA
.*: : . . . : . .. .* .: .: .:** . .
Mflv_2196|M.gilvum_PYR-GCK AVTAQMWRAARAATGTAMAALALAALIRGIGDVIDNSGSALSWFSPIAWA
Mvan_4500|M.vanbaalenii_PYR-1 AVTAQMWRAARAATGAAMATLALAALVRGIGDVIDNSGSVLSWFSPIAWA
MSMEG_5076|M.smegmatis_MC2_155 ALTAQMWRQARAATGAAMAALGVAALIRGVGDVIDNSGSILSWFSPIAWA
TH_4424|M.thermoresistible__bu AVTAQLWRTSRAATGAALGALAAAVVVRGVGDVINHSGSVVSWLSPVAWA
MAB_1358c|M.abscessus_ATCC_199 AVTAQLWRTARAASGAAMAALAAAVVVRGLGDIIDNKGSALSWFSPLAWA
Mb1249c|M.bovis_AF2122/97 AVAAQLSPSARFTRAVAFAVLGTAFALRAIGDAGSGT---LSWCSPLGWS
Rv1217c|M.tuberculosis_H37Rv AVAAQLSPSARFTRAVAFAVLGTAFALRAIGDAGSGT---LSWCSPLGWS
MMAR_4221|M.marinum_M AVCAQLSPSARSCRSAAFAVLGTAFTLRAIGDAGSGA---LSWFSPLGWS
MAV_1361|M.avium_104 AVTAQLSPSARFARGAAFAVLGTSFTVRAVGDAGPGG---LSWLSPLGWS
*: **: :* ..*:..*. : :*.:** :** **:.*:
Mflv_2196|M.gilvum_PYR-GCK QQMRSFVDLRWWPLALLIGLTLALVTLAAALERRREYDDATLSSR-GEHP
Mvan_4500|M.vanbaalenii_PYR-1 QQMRPFVELRWWPLALLSALSLTLVAIAAALEVQREYDDATIVSS-GESP
MSMEG_5076|M.smegmatis_MC2_155 QQMRPFVALRCWPFALLVLLAVALIALAAVAEARRQYDDGTIPAT-GDRP
TH_4424|M.thermoresistible__bu QQMRAFVEVRWWPLALLVLLTVVLLGAAAVLERSREYDAGTLPAG-GDRP
MAB_1358c|M.abscessus_ATCC_199 QQMRPFVDLRWWPFLLLLGTTLALMLTAHLLEGHRQYDAGVLPSR-GENP
Mb1249c|M.bovis_AF2122/97 LQVRPYAGERWWVLLLSLATAAVLTVLAYRLRAGRDVGAGLIAERPGAGT
Rv1217c|M.tuberculosis_H37Rv LQVRPYAGERWWVLLLSLATAAVLTVLAYRLRAGRDVGAGLIAERPGAGT
MMAR_4221|M.marinum_M LLVRPYAGERWWVLLLPLATTAALTVLAYRLRAGRDVGAGLIAERAGAGA
MAV_1361|M.avium_104 LLVKPYAGDRWWVLVLHLVTTAGLTVLAYRLLAGRDVGAGLIAERPGPAT
::.:. * * : * : * * *: . . : * .
Mflv_2196|M.gilvum_PYR-GCK GARPVRGVLALHLVLQRGQTIGWSAGLFIAGLAFGSMTKSLLDAAEGNEL
Mvan_4500|M.vanbaalenii_PYR-1 NARPIRGVLALHLRLQRGQTLGWSVGLFAAGLAFGSMTKSLLEAAHDNEL
MSMEG_5076|M.smegmatis_MC2_155 DAAPITGVLGLHLRLHRGQTIAWGAGLFVAGLAFGSMTKSLMDAAQTNEL
TH_4424|M.thermoresistible__bu GAPPIRGVFGLQLVLQRGQLIGWSVGLFLGGLTFGSLTQAMLDIAEENEL
MAB_1358c|M.abscessus_ATCC_199 NAPEIKTVVGLNGQLQRGLITGWGFGVFLGGMAFGSMAKSLRDSIDTNPL
Mb1249c|M.bovis_AF2122/97 AGPMLSEPFGLAWRLNRGSLLLWTVGLCLYGLVMGSVVHGIGDQLGDNTA
Rv1217c|M.tuberculosis_H37Rv AGPMLSEPFGLAWRLNRGSLLLWTVGLCLYGLVMGSVVHGIGDQLGDNTA
MMAR_4221|M.marinum_M AAPMLSNTFGLAWRLDRGALLLWTIGLCLYGLVMGSVVHGIGDQLGDNTA
MAV_1361|M.avium_104 AAPRLGNAFGLAWRLDRAALLLWTAGLALYGLLIGSVVHGIGDELGDSGQ
. : ..* *.*. * *: *: :**:.:.: : .
Mflv_2196|M.gilvum_PYR-GCK IAQMISAQG-----TDGVYMTMSQFLAAAASAYVVACVLRLHADERSGLG
Mvan_4500|M.vanbaalenii_PYR-1 LARIVSTQG-----LDGVYTTMTQFLAAAAGAYVVSAVLRVFADEQSGLG
MSMEG_5076|M.smegmatis_MC2_155 IAQVLAAQG-----PDGAYTTMTQFLAAAAAAYTVSGVLRLYDDEQNGRA
TH_4424|M.thermoresistible__bu VAAMLAAHG-----NAGIFTTMTQFLAAATTAFIAITVLRLRSDEQSGLA
MAB_1358c|M.abscessus_ATCC_199 LARAFTAHG-----LDSIFATFNQVLAIAVTAYAVSAILRLAKDEQSGIT
Mb1249c|M.bovis_AF2122/97 VRDIVTRMGGTGALEQAFLALAFTMIGMVAAAFAVSLTLRLHQEETGLRA
Rv1217c|M.tuberculosis_H37Rv VRDIVTRMGGTGALEQAFLALAFTMIGMVAAAFAVSLTLRLHQEETGLRA
MMAR_4221|M.marinum_M VREIVTRMGGTAALEEAFVTLAFTLVGMVAAAFAISLTLRLHQEETGQRA
MAV_1361|M.avium_104 ARDIVARMGGTSALEDAFIAVAFAMMGMVAAAFAVSLTLRLHQEESSQRA
.: * . .:. .. *: **: :* .
Mflv_2196|M.gilvum_PYR-GCK ESVLAGAVSRWRWLSTSVVAAVLGATVLMFFAGLGNGVGAGITLGEP-GT
Mvan_4500|M.vanbaalenii_PYR-1 EAVLAGAVSRPRWLSTAVLSAVLGASVLMFFAGLGNGLGAGVTLGEP-AT
MSMEG_5076|M.smegmatis_MC2_155 EAVLAGPVSRWRWLLGATVAAVLGSAVVLLCAGVGNGLGAGLTLGDL-PT
TH_4424|M.thermoresistible__bu EPVLAGSVSRWQWLLSTVAATLLGAATLLFFAGLGNGLGAGIALGDP-GT
MAB_1358c|M.abscessus_ATCC_199 EAVLARAVSRWTWLLSAVAMTALGSALLMTIAGLGAGLGAASTLHDP-DL
Mb1249c|M.bovis_AF2122/97 ETLLAGAVSRTHWLASHLAMALAGSAVATLISGVAAGLAYGMTVGDVGGK
Rv1217c|M.tuberculosis_H37Rv ETLLAGAVSRTHWLASHLAMALAGSAVATLISGVAAGLAYGMTVGDVGGK
MMAR_4221|M.marinum_M EPLLAGSVSRTRWLSSHLVMALAGSAVATVLSGLVAGIAYGIAAGDVGAK
MAV_1361|M.avium_104 ETVLASAVSRTRWLASHLVIALAGSGVAMLASGTVAGLVYGIAAGDVGGK
*.:** .*** ** : *: :* *: . : :
Mflv_2196|M.gilvum_PYR-GCK VGRLTVAGLAFVPALAVMAGVAA--VGVALRQPWIGWLAVASVVLSLYLG
Mvan_4500|M.vanbaalenii_PYR-1 VLRLTVAGLAFVPALAVLAGVAA--LAVALRQSWIGWLAVTFVVASLYLG
MSMEG_5076|M.smegmatis_MC2_155 VGRLALAALAYLPALAVMAAVAT--LAVALRTPWIAWLAVAFVIVALYLG
TH_4424|M.thermoresistible__bu VGELVLSALAHLPAMAVMTGIAA--LAFALRMNWIAWLTVTFVIVSLYMG
MAB_1358c|M.abscessus_ATCC_199 VWRLILAGLAQIPALLVVCGIAA--VAVALRQSWIGWVVVAFSVGMLYAG
Mb1249c|M.bovis_AF2122/97 LPTVVGTAAVQLPAVWLLSAVTVGLFGLAPRFTPVAWGVLVGFIALYLLG
Rv1217c|M.tuberculosis_H37Rv LPTVVGTAAVQLPAVWLLSAVTVGLFGLAPRFTPVAWGVLVGFIALYLLG
MMAR_4221|M.marinum_M LATVVGAAAVQLPAVWLLAAVAVGLFGLAPRFTPVVWGVLIGFVALYLLG
MAV_1361|M.avium_104 LAMVVASAAVQLPAVWLLSAVTVCVFGVAPRFAPVAWGVLIGFVALYLIG
: : :. . :**: :: .::. ...* * : * .: : *
Mflv_2196|M.gilvum_PYR-GCK ALLRLPRWLIDLSPVSRTTVPT--DVPVVALVVMCVAAATLTVLAGFLYR
Mvan_4500|M.vanbaalenii_PYR-1 ALLRLPGWLLDLSPVAQTSYPA--DVPALGWFVMCCAAAALTVFAAVRYR
MSMEG_5076|M.smegmatis_MC2_155 ALLRLPRWLLDLSPVGRTTAPM--DYPVTALFVMAVVAVLLACAAGGLYR
TH_4424|M.thermoresistible__bu ALLRVPQWLLDLSPVTRIKVPM--ETSVTTMVVMVLIGAALTATAGWRYR
MAB_1358c|M.abscessus_ATCC_199 -ILQLPTWMVKLSPVMRVSAPV--EYPWLTMSLLIVLGAGLAAAAGALYR
Mb1249c|M.bovis_AF2122/97 SLAGFPQMLLNLEPFAHIPRVGGGDFTAVPLLWLLAIDAALITLGAMAFR
Rv1217c|M.tuberculosis_H37Rv SLAGFPQMLLNLEPFAHIPRVGGGDFTAVPLLWLLAIDAALITLGAMAFR
MMAR_4221|M.marinum_M SLAGFPQWLLDLEPFAHVPRIG-RDFTAVPLLWLLAIDITLILLGALALR
MAV_1361|M.avium_104 SLAGFSQWLLDLEPFAHIPRVG-ADFTAVPLLWLLAIDIGLTILGAMAFR
: .. ::.*.*. : : . : * .. *
Mflv_2196|M.gilvum_PYR-GCK RRDAA-
Mvan_4500|M.vanbaalenii_PYR-1 HRDAV-
MSMEG_5076|M.smegmatis_MC2_155 RRDAV-
TH_4424|M.thermoresistible__bu GRDAL-
MAB_1358c|M.abscessus_ATCC_199 RRDAI-
Mb1249c|M.bovis_AF2122/97 RRDVRC
Rv1217c|M.tuberculosis_H37Rv RRDVRC
MMAR_4221|M.marinum_M RRDLRC
MAV_1361|M.avium_104 RRDLRC
**