For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_3338 | - | - | 100% (497) | acyl-CoA synthase |
| M. thermoresistible (build 8) | TH_3085 | - | e-163 | 57.43% (491) | PUTATIVE AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_4613 | - | e-144 | 53.33% (495) | PUTATIVE AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0220 | fadD4 | 1e-135 | 51.02% (492) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0449 | - | 1e-138 | 51.38% (506) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv0214 | fadD4 | 1e-135 | 51.02% (492) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 2e-52 | 30.67% (489) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_3435 | - | 1e-176 | 61.29% (496) | acyl-CoA synthetase |
| M. marinum M | MMAR_0452 | fadD4 | 1e-128 | 48.37% (492) | fatty-acid-CoA ligase FadD4 |
| M. avium 104 | MAV_5098 | - | 0.0 | 77.00% (487) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_0257 | - | 1e-134 | 51.22% (492) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_1191 | fadD2 | 5e-52 | 30.20% (490) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0015 | - | 0.0 | 62.93% (491) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0220|M.bovis_AF2122/97 ------------------------MPRGELYKRFRLVMGGIAPCGSGRRA
Rv0214|M.tuberculosis_H37Rv ------------------------MPRGELYKRFRLVMGGIAPCGSGRRA
MMAR_0452|M.marinum_M --------------------------------------------------
MSMEG_0257|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0449|M.gilvum_PYR-GCK --------------------------------------------------
TH_3338|M.thermoresistible__bu --------------------------------------------------
MAV_5098|M.avium_104 --------------------------------------------------
Mvan_0015|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3435|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02546|M.leprae_Br4923 ---------MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVA
MUL_1191|M.ulcerans_Agy99 MPNLSDLPGVAKIQQYVDRGAAELHYVRKIIESGAFRLESPLNYAAMATE
Mb0220|M.bovis_AF2122/97 ATYPRRMQIRPYIAA--DKPAVILYPSGTVISFDELEARANRLAHWFRQA
Rv0214|M.tuberculosis_H37Rv ATYPRRMQIRPYIGA--DKPAVILYPSGTVISFDELEARANRLAHWFRQA
MMAR_0452|M.marinum_M ------MQIRQHVGA--DKPAVILHPSGTVVSFDELEARANRLAHRFRRA
MSMEG_0257|M.smegmatis_MC2_155 ------MQIREHVGA--NKPAIILYPSGTVVTFDELEARANRLAHHFRNQ
Mflv_0449|M.gilvum_PYR-GCK ------MQIRDTAVATPDKPAVIMYPAGTVVTFGELEARANRLAHLFRDA
TH_3338|M.thermoresistible__bu -----------------------MAGTGAVLTYGQLEDRSARLAAALHIT
MAV_5098|M.avium_104 ------------------------------MTYRELDENSARLASALHSV
Mvan_0015|M.vanbaalenii_PYR-1 ------MYPGTHARTAPERAAVVVAETGETLSYRRLDEQSAALARVLHDA
MAB_3435|M.abscessus_ATCC_1997 ------MYPGAHAAQFPDKPAVVMAGSGATLTYGELDRQSRRLARHWYDS
MLBr_02546|M.leprae_Br4923 MRKWGDLAMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAK
MUL_1191|M.ulcerans_Agy99 IAKWGEFGMLPSFNARRHPHRAACIDEEGEFTYQQLDEAGHAVANALLAK
.:: .*: . :*
Mb0220|M.bovis_AF2122/97 GLREDDVVAILMENNEHVHAVMWAARRSGLYYVPINTHLTASEAAYIVDN
Rv0214|M.tuberculosis_H37Rv GLREDDVVAILMENNEHVHAVMWAARRSGLYYVPINTHLTASEAAYIVDN
MMAR_0452|M.marinum_M GLREGDAVAILMENNEHIHAVMWAARRSGLYYVPINTHLTAAEAAYIIEN
MSMEG_0257|M.smegmatis_MC2_155 GLQEGDVVAILMENNSHIHTVMWAARRSGLYYVPISTHLTAAEAAYIVDN
Mflv_0449|M.gilvum_PYR-GCK GLVEGDAVALLMENNEHFHAVMWAARRAGLYYVPINTHLTAAEVAYIVDN
TH_3338|M.thermoresistible__bu GLRSGDVIALLTDNTATAFEVYWAALRSGLYITAINWHLAPEEAAYIVSD
MAV_5098|M.avium_104 GLRKGDVIAMLSDNAVEAFEIYWAAIRSGLYITAINWHLAAEEAAYILRD
Mvan_0015|M.vanbaalenii_PYR-1 GLRPGDVVVLLSDNAPEALVVLWAAQRSGLYVTAINHHLTPAEAGYIVCD
MAB_3435|M.abscessus_ATCC_1997 GLRKGDHVALLSDNVPEVFVVYWAALRSGLYITSVNHHLAPAEVSYIVND
MLBr_02546|M.leprae_Br4923 GVRGGDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSER
MUL_1191|M.ulcerans_Agy99 GVSAGDGVAILARNHRWFLIANYGAARAGARIILLNSEFSGPQIKEVSER
*: .* :.:* * :.. * * :. .:: : :
Mb0220|M.bovis_AF2122/97 SGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAG----------GGLVG
Rv0214|M.tuberculosis_H37Rv SGAKAIVGSAALRETCHGLAEHLPGGLPDLLMLAG----------GGLVG
MMAR_0452|M.marinum_M SGAKAIVGSAALRDTCAGLGEHLRAGPPELLILAGPE--------GCLTG
MSMEG_0257|M.smegmatis_MC2_155 SGAKAIVGSAKMRDVLAGLGDELPNGLPDTLLIAD----------GDLDG
Mflv_0449|M.gilvum_PYR-GCK SGAKAIVGSAKLADTLAGLEAELPNGLPQLLLVAGAELSATSASGGDVDG
TH_3338|M.thermoresistible__bu SGAKVVFCSAGVRDLGEQVAKLVTD--VEQWYAFG----------GPVDG
MAV_5098|M.avium_104 SGARVLIASAGVAELAEQLTGLVPD--LKHRYAFG----------GAVAG
Mvan_0015|M.vanbaalenii_PYR-1 SGARALVASAALRELADGVVAEAGG--PEVRIAFG----------GRIDG
MAB_3435|M.abscessus_ATCC_1997 SGSSALVVAAGVREQAEAILDDTPA--VTLRLAFG----------GDVRG
MLBr_02546|M.leprae_Br4923 EGAKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEE--------PPGST
MUL_1191|M.ulcerans_Agy99 EGAKLIIYDDEYTGAVSKAEPPLGKLRALGVNPDSEE--------DSGST
.*: :.
Mb0220|M.bovis_AF2122/97 WMTYPECVADQPDTPIEDE-REGDLLQYSSGTTGRPKGIKRELPHVSPDA
Rv0214|M.tuberculosis_H37Rv WMTYPECVADQPDTPIEDE-REGDLLQYSSGTTGRPKGIKRELPHVSPDA
MMAR_0452|M.marinum_M WEPYPQCVADQPDTAIDDE-LEGDLLQYSSGTTGRPKGIKRELLHVAPDA
MSMEG_0257|M.smegmatis_MC2_155 WLRYPEAVADLPDTPIDDE-LDGDLLQYSSGTTGRPKGIKRELPHVHPSE
Mflv_0449|M.gilvum_PYR-GCK WQRYPECVADKLETPIADE-IDGDLLQYSSGTTGRPKGIKRELPHLPPAE
TH_3338|M.thermoresistible__bu YASYDGLLASAGDTRLTDQ-PRGSEMLYSSGTTGRPKGIKPHRIPVQIDE
MAV_5098|M.avium_104 YAPYRELLAPA--PRLKEQ-PRGSEMLYSSGTTGRPKGIKPRLLPIQVDE
Mvan_0015|M.vanbaalenii_PYR-1 FADYESTLAAAG-PPLAEQ-PCGAVMLYSSGTTGFPKGIRPDLPERSVDQ
MAB_3435|M.abscessus_ATCC_1997 YDSYEDALDGASDEPLPAQ-PAGSDMLYSSGTTGRPKGIKVPLTDRQVDE
MLBr_02546|M.leprae_Br4923 DETLAELIARSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTP--ASLA
MUL_1191|M.ulcerans_Agy99 DETLAELIARSSTAPAPKAGKHASIIILTSGTTGTPKGANRSTP--PTLA
: . : :***** *** .
Mb0220|M.bovis_AF2122/97 APGMMPALLD--FWMDADSVYLSPAPMYHTAPSVWTMSALAAGVTTVVME
Rv0214|M.tuberculosis_H37Rv APGMMPALLD--FWMDADSVYLSPAPMYHTAPSVWTMSALAAGVTTVVME
MMAR_0452|M.marinum_M APGMMSALVG--YWMDADSIYLSPAPLYHTAPSVWSMSAQAGGITTVVLE
MSMEG_0257|M.smegmatis_MC2_155 NPGMMAALIS--FWMTPDSVYLSPAPLYHTAPSVWSMQVQAAGHTTVVME
Mflv_0449|M.gilvum_PYR-GCK VPGMMAMLVE--FWMHPDAVYLSPAPLYHTAPSVWSMQVQAGGITTVVME
TH_3338|M.thermoresistible__bu PADPIVGLLQHAFGVSDDDVYLSPAPIYHTAPLKWCGAVHALGGTVVLME
MAV_5098|M.avium_104 PGDPLVGLLAHAFKICADDVYLSPAPIYHTAPLKWCAGVQALGGTVVLME
Mvan_0015|M.vanbaalenii_PYR-1 PGDPVVAIAGGLFGITSSDVYFSSAPIYHAAPLRWCGMVHALGGTVVLAK
MAB_3435|M.abscessus_ATCC_1997 P-NPFAMLFAHLYGFNAETVYLSPAPIYHAAPLRFCGFVQSMGGTAVVME
MLBr_02546|M.leprae_Br4923 PLGGILSKVP----FRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRR
MUL_1191|M.ulcerans_Agy99 PVGGILSHVP----FKANEVTSLPAPMFHALGYLHATIAMFLGSTLVLRR
. . . : .**::*: . * * *: .
Mb0220|M.bovis_AF2122/97 KFDAEGALDAIQRYRVTHAQFVPAMFVRMLKLPEAVRNSYDMSSLRRVIH
Rv0214|M.tuberculosis_H37Rv KFDAEGALDAIQRYRVTHAQFVPAMFVRMLKLPEAVRNSYDMSSLRRVIH
MMAR_0452|M.marinum_M KFDPEGALEAIQRHRVTHAQFVPAMFTRMLKLPESIRNSYDVSSLKRVMH
MSMEG_0257|M.smegmatis_MC2_155 KFDAEGCLEAIQKHRVTHGQFVPAMFTRMLKLPESVRNSYDVSSLKRVMH
Mflv_0449|M.gilvum_PYR-GCK KFDAEGALDAIQKYKVTHGQFVPVMFARMLKLPEDVRKSYDVSSLQRVMH
TH_3338|M.thermoresistible__bu RFDAEQTLDAIEKYRVTATQMVPTMFVRMLQLPEEVRSRYDVSSLRLAVH
MAV_5098|M.avium_104 RFDAEKALAAIEKYKTTVMQVVPTMFVRMLQLSEAVRAGYDVSSLRLAVH
Mvan_0015|M.vanbaalenii_PYR-1 RFDAADTLRYIEKFRITATQMVPTMFVRMLKLNDEVRSRYDLSSLRGVIH
MAB_3435|M.abscessus_ATCC_1997 RFEAEEALAAIEKYRITHSQWVPTMFVRMLKLPKEIRDRYDVSSLKVAVH
MLBr_02546|M.leprae_Br4923 RFKPATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFV
MUL_1191|M.ulcerans_Agy99 KFKPQLVLEDIEKHKVTAMVVVPVMLSRLLDAVEKIDKKPDLSSLKIVFV
:*.. * *::.: * **.*: *:*. . : *:***: ..
Mb0220|M.bovis_AF2122/97 AAAPCPVQIKEQMIHWWGPIIDEYYASSEASGSTLITAEDWLTHPGSVGK
Rv0214|M.tuberculosis_H37Rv AAAPCPVQIKEQMIHWWGPIIDEYYASSEASGSTLITAEDWLTHPGSVGK
MMAR_0452|M.marinum_M AAAPCPVEIKKQMMDWWGPIIDEYYASSEAIGSTLITAEDWLEHPGSVGK
MSMEG_0257|M.smegmatis_MC2_155 AAAPCPVDIKKQMIDWWGPIVDEYYASSEAIGATLITAEEWLKHPGSVGK
Mflv_0449|M.gilvum_PYR-GCK AAAPCPVEIKKQMIDWWGPIVDEYYASSEAHGSTLITADQWLERPGSVGK
TH_3338|M.thermoresistible__bu AAAPCPPDVKDAMIHWWGPILVEYYGATEQHGTTIITTEEWRTKRGSVGR
MAV_5098|M.avium_104 AAAPCAPDVKDAMIDWWGPILVEYYGATEQHGTTVITTAEWQKKRGSVGR
Mvan_0015|M.vanbaalenii_PYR-1 AAAPCPVDVKQAMIDWLGPIIWEYYSSTEVHGMTVIDTGQWLSHQGSVGR
MAB_3435|M.abscessus_ATCC_1997 AAAPCPVEVKQSMIDWWGPILYEYYSSTEGNGVTFIDCATWLKRPGSVGS
MLBr_02546|M.leprae_Br4923 SGSQLGAELATRALEELGPVIYNMYGSTEIAFATIAGPKDLQINSATVGP
MUL_1191|M.ulcerans_Agy99 SGSQLGAELASRALKDLGPVIYNMYGSTEIAFATIAGPEDLQRNAATVGP
:.: :: :. **:: : *.::* *. . .:**
Mb0220|M.bovis_AF2122/97 PIQGG-VHIVGADGSELPPNQPGEIYFEGG-YPFEYLNDPAKTAASRNKH
Rv0214|M.tuberculosis_H37Rv PIQGG-VHIVGADGSELPPNQPGEIYFEGG-YPFEYLNDPAKTAASRNKH
MMAR_0452|M.marinum_M PMQGG-VHILGADGVELPPGQAGEIYFEGG-YSFEYLNDPSKTAASRDKH
MSMEG_0257|M.smegmatis_MC2_155 PLTGI-VHVLDEDGNELPPGQAGEIFFEGG-QDFEYLNDAEKTASSRDAR
Mflv_0449|M.gilvum_PYR-GCK PLTGV-VHIVGEDGNELPAGQAGEIYFEGG-YDFEYLNDPDKTASSRHPQ
TH_3338|M.thermoresistible__bu AAMGI-LHICDDAGAELPPGEIGTIYFEREVAPFVYHNDPEKTAQSRHPQ
MAV_5098|M.avium_104 AALGV-LHICDDDGRELSAGEVGTVYFERDVAPFEYHNDPEKTASSRHPV
Mvan_0015|M.vanbaalenii_PYR-1 SVLGT-LHICDDDGHDLPAGEVGTVYFERDALPFSYHNAPEKTAEAQHPA
MAB_3435|M.abscessus_ATCC_1997 AALGV-LHICDETGAELPAGEAGLVYFEREELPFSYHNDDEKTRSACHPA
MLBr_02546|M.leprae_Br4923 VVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGGGGKQIIDG---
MUL_1191|M.ulcerans_Agy99 VVKGVKVKILDDNGNEVSQGQVGRIFVGNAFPFEGYTGGGHKQIIDG---
* ::: . * ::. .: * ::. * . *
Mb0220|M.bovis_AF2122/97 G--WVTVGDVGYLDDDGYLFLTGRRHHMIISGGVNIYPQEAENLLVAHPK
Rv0214|M.tuberculosis_H37Rv G--WVTVGDVGYLDDDGYLFLTGRRHHMIISGGVNIYPQEAENLLVAHPK
MMAR_0452|M.marinum_M G--WVTVGDVGYLDDQGYLFLTDRRHHMIISGGVNIYPQEAENILVTHPK
MSMEG_0257|M.smegmatis_MC2_155 G--WKTVGDIGYLDEEGYLYLTDRRHHMIISGGVNIYPQEAENMLVTHPK
Mflv_0449|M.gilvum_PYR-GCK G--WKTVGDIGYVDEEGFLFLTDRRHHMIISGGVNIYPQEAENLLVTHPK
TH_3338|M.thermoresistible__bu HENWCTVGDVGYVDEDGYLFLTDRKGFTIISGGVNIYPQEIENVLTLHPK
MAV_5098|M.avium_104 FDNWSTVGDIGYVDEDGYLFLTDRKAFVIISGGVNIYPQEVENVLTLHPK
Mvan_0015|M.vanbaalenii_PYR-1 HPFWTTVGDLGYVDDEGYLYLADRKAFMIISGGVNIYPQEVENALTLHPA
MAB_3435|M.abscessus_ATCC_1997 HDTWTTTGDIGYVDEDGFLYLTDRKAFMIISGGVNIYPQEIENALALHPA
MLBr_02546|M.leprae_Br4923 ---LLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPE
MUL_1191|M.ulcerans_Agy99 ---LMSSGDVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEALISGHPD
: **:**.*:.. *:::.* *:*** *::* * * : **
Mb0220|M.bovis_AF2122/97 VLDAAVFGVPDDEMGQRVMAAVQTVDSADANDQFAGELLAWLRDRLSHFK
Rv0214|M.tuberculosis_H37Rv VLDAAVFGVPDDEMGQRVMAAVQTVDSADANDQFAGELLAWLRDRLSHFK
MMAR_0452|M.marinum_M VMDAAVFGVPDDEMGQRVMAVVQTVDPADATSQFGDELMEWLRDRLSHFK
MSMEG_0257|M.smegmatis_MC2_155 VMDAAVFGVPDDEMGQSVKGVVQTVDPADATPEFGEELLAWLRDRLAHYK
Mflv_0449|M.gilvum_PYR-GCK VMDAAVFGIPDEEMGQRVKAVVQLVDQADATEEFADELIGWLRDRLAHYK
TH_3338|M.thermoresistible__bu IFDVAVIGVPDPEMGEQVKAVVQLREGVEASDELAAEIIAYVRERIAHYK
MAV_5098|M.avium_104 VFDVAVIGVPDPEMGEQVKAVIQLRSGTTPSDQLADEIIAYVRERIAHYK
Mvan_0015|M.vanbaalenii_PYR-1 VHDVAVIGVPDPEMGEQVKAVVHLTAGVDPSEELARELIDYTRARIAHYK
MAB_3435|M.abscessus_ATCC_1997 VLDVAVIGVPDAEMGESVKAVVQPADSSAAPRELAAELTDFLRERIARYK
MLBr_02546|M.leprae_Br4923 VVEATAIGVDDKEWGARLRAFVVKKQDATID---EDAIKAYVRDHLARYK
MUL_1191|M.ulcerans_Agy99 VVEATALGVDDKEWGARLRAFVVKKPDTDLD---EETVKHYVRDHLARYK
: :.:.:*: * * * : . : : : * :::::*
Mb0220|M.bovis_AF2122/97 CPRSIAFEPQLPRTDTGKLYKSGLVEKYSV---
Rv0214|M.tuberculosis_H37Rv CPRSIAFEPQLPRTDTGKLYKSGLVEKYSV---
MMAR_0452|M.marinum_M CPRSVAFEAQLPRTDTGKLYKNGLIEKYSG---
MSMEG_0257|M.smegmatis_MC2_155 CPRSISFELQLPRTDTGKLYKQELIAKYS----
Mflv_0449|M.gilvum_PYR-GCK CPRSLSFEEQLPRTDTGKLYKQELIKKYS----
TH_3338|M.thermoresistible__bu APRSVDFVDELPRLATGKLAKRVLINRYQEAAR
MAV_5098|M.avium_104 APRSVDFVDDLPRTATGKLMKRTLKARYMEATA
Mvan_0015|M.vanbaalenii_PYR-1 APRSVDFVDDLPRTPTGKLVKGKLRERYLVDV-
MAB_3435|M.abscessus_ATCC_1997 VPRSFDFTDTLPRTPTGKLAKGLLRQKYWEGAQ
MLBr_02546|M.leprae_Br4923 VPREVIFLEELPRNPTGKVLKRELRDFEVH---
MUL_1191|M.ulcerans_Agy99 VPREVIFLEELPRNPTGKILKRELREMEIE---
**.. * *** ***: * *