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M. thermoresistible (build 8) TH_2384 (-)

annotation: IMP dehydrogenase family protein
coordinates: 4657892 - 4659334
length: 481

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2384--100% (481)IMP dehydrogenase family protein
M. thermoresistible (build 8)TH_3086-4e-2840.86% (186) PUTATIVE inosine-5'-monophosphate dehydrogenase
M. thermoresistible (build 8)TH_1679guaB28e-1731.16% (215) PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB2 (IMP

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1874cguaB10.080.21% (480) inosine 5-monophosphate dehydrogenase
M. gilvum PYR-GCKMflv_3360-0.082.08% (480) inositol-5-monophosphate dehydrogenase
M. tuberculosis H37RvRv1843cguaB10.080.21% (480) inosine 5-monophosphate dehydrogenase
M. leprae Br4923MLBr_02066guaB10.079.58% (480) inosine 5-monophosphate dehydrogenase
M. abscessus ATCC 19977MAB_2412c-0.074.17% (480) inosine 5-monophosphate dehydrogenase
M. marinum MMMAR_2717guaB10.082.29% (480) inosine-5'-monophosphate dehydrogenase GuaB1
M. avium 104MAV_2872-0.079.79% (480) inositol-5-monophosphate dehydrogenase
M. smegmatis MC2 155MSMEG_3634-0.084.79% (480) inositol-5-monophosphate dehydrogenase
M. ulcerans Agy99MUL_3036guaB10.082.08% (480) inosine 5-monophosphate dehydrogenase
M. vanbaalenii PYR-1Mvan_3090-0.082.92% (480) inositol-5-monophosphate dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3360|M.gilvum_PYR-GCK          -MQFLDGHRPPYDLTYNDVFVVPGRSEVTSRFDVDLSTVDGAGTTIPVVV
Mvan_3090|M.vanbaalenii_PYR-1       -MKFLDDQRPPYDLTYNDVFVVPGRSEVLSRFDVDLSTVDGSGTTIPVVV
Mb1874c|M.bovis_AF2122/97           MMRFLDGHPPGYDLTYNDVFIVPNRSEVASRFDVDLSTADGSGTTIPVVV
Rv1843c|M.tuberculosis_H37Rv        MMRFLDGHPPGYDLTYNDVFIVPNRSEVASRFDVDLSTADGSGTTIPVVV
MLBr_02066|M.leprae_Br4923          -MRFLDGHQPRFDLTYKDVFIVPHRSDVASRFDVDLSTYDGSGTTIPVVV
MAV_2872|M.avium_104                -MRFLDGHRPGYDLTYNDVFIMPNRSEVPSRFDVDLSTGDGSGTTIPVVV
MMAR_2717|M.marinum_M               -MRFLDGHRPGYDLTYNDVFIMPNRSLVASRFDVDLSTADGSGTTIPVVV
MUL_3036|M.ulcerans_Agy99           -MRFLDGHRPGYDLTYNDVFIMPNRSLVASRFDVDLSTADGSGTTIPVVV
TH_2384|M.thermoresistible__bu      -MRFLDGHRPPYDLTYDDVFIMPGRSDLASRLDVDLSTVDGSGTTIPIVV
MSMEG_3634|M.smegmatis_MC2_155      -MRFLDGHTPAYDLTYNDVFVVPGRSDVASRFDVDLSTVDGSGTTIPVVV
MAB_2412c|M.abscessus_ATCC_199      -MKFLDGQRPPYDLTYDDVFVVPNHSDVTSRFDVDLTTADGTGTTIPIVV
                                     *:***.: * :****.***::* :* : **:****:* **:*****:**

Mflv_3360|M.gilvum_PYR-GCK          ANMTAVAGRRMAETVARRGGIVVLPQDLPPSAVRHTVDFVKSRDTVVDTP
Mvan_3090|M.vanbaalenii_PYR-1       ANMTAVAGRRMAETVARRGGIVVLPQDLPVSAVKQTVDFIKSRDTVVDTP
Mb1874c|M.bovis_AF2122/97           ANMTAVAGRRMAETVARRGGIVILPQDLPIPAVKQTVAFVKSRDLVLDTP
Rv1843c|M.tuberculosis_H37Rv        ANMTAVAGRRMAETVARRGGIVILPQDLPIPAVKQTVAFVKSRDLVLDTP
MLBr_02066|M.leprae_Br4923          ANMTTVAGQRMAETVARRGGLVILPQDLPIATVQQAVEFVKSRDLVIDTP
MAV_2872|M.avium_104                ANMTAVAGRRMAETVARRGGLVILPQDLPITAVQQTVQFVKSRDLVLDTP
MMAR_2717|M.marinum_M               ANMTAVAGRRMAETVARRGGIVVLPQDLPIPAVHQTVEFIKSRDLVLDTP
MUL_3036|M.ulcerans_Agy99           ANMTAVAGRRMAETVARRGGIVVLPQDLPIPAVHQTVEFIKSRDLVLDTP
TH_2384|M.thermoresistible__bu      ANMTAVAGRRMAETVARRGGLVVLPQDLPIEVVRHTVDFVKSRDLVVDTP
MSMEG_3634|M.smegmatis_MC2_155      ANMTAVAGRRMAETVARRGGIVVLPQDLPITAVSETVDFVKSRDLVVDTP
MAB_2412c|M.abscessus_ATCC_199      ANMTAVAGRRMAETVARRGGITVLPQDLPVQAVAQTVEFIKSRDLVYDTP
                                    ****:***:***********:.:******  .* .:* *:**** * ***

Mflv_3360|M.gilvum_PYR-GCK          VTLSPDDSVSDAAALIHKRAHGAAVVLDHD-RPVGLVTEAACHGVDRFTR
Mvan_3090|M.vanbaalenii_PYR-1       VTLSPDDSVSDAIALIHKRAHGAAVVLFEN-RPIGLVTEASCAGVDRFTR
Mb1874c|M.bovis_AF2122/97           VTLAPDDSVSDAMALIHKRAHGVAVVILEG-RPIGLVRESSCLGVDRFTR
Rv1843c|M.tuberculosis_H37Rv        VTLAPDDSVSDAMALIHKRAHGVAVVILEG-RPIGLVRESSCLGVDRFTR
MLBr_02066|M.leprae_Br4923          VLLTPNDSVSDATTLIHKRAHGVAVVAFEG-RPIGLVRESSCLGVDRFTR
MAV_2872|M.avium_104                VLLEPDDSVSDAMALIHKRAHGVAVVAFEG-RPLGLVSESSCLGVDRFTR
MMAR_2717|M.marinum_M               VTLAPEDSVSDAIALIHKRAHGVAVVVSEG-RPIGLVTEASCVGVDRFAR
MUL_3036|M.ulcerans_Agy99           VTLAPEDSVSDAIALIHKRAHGVAVVVSEG-RPIGLVTEASCVGVDRFAR
TH_2384|M.thermoresistible__bu      VTLGPEDSVSDAIALIHKRAHGAAVVVDEHNRPVGLVTEDNCVGVDRFTR
MSMEG_3634|M.smegmatis_MC2_155      VTLSPEDSVSDANALLHKRAHGAAVVVFEG-RPIGLVTEANCAGVDRFAR
MAB_2412c|M.abscessus_ATCC_199      VTLAPDDSAGEAIALIHKRSHGAAVVLEHG-KPLGLVTEAACTGIDRFTR
                                    * * *:**..:* :*:***:**.***  .  :*:*** *  * *:***:*

Mflv_3360|M.gilvum_PYR-GCK          VCDVAITDFVTAPAGTDPRKVFDLLEHA-HIDVAVLTDADGSLAGVLTRT
Mvan_3090|M.vanbaalenii_PYR-1       VRDVVVSDFVSVPVGTDPRKVFDLLEHA-PVDVAVLTEADGSLAGVLTRT
Mb1874c|M.bovis_AF2122/97           VRDIAVTDYVTAPAGTEPRKIFDLLEHA-PVDVAVLTDADGTLAGVLSRT
Rv1843c|M.tuberculosis_H37Rv        VRDIAVTDYVTAPAGTEPRKIFDLLEHA-PVDVAVLTDADGTLAGVLSRT
MLBr_02066|M.leprae_Br4923          VRDVATTDFVTAPVGTDPRKIFDLLEHA-PIDVAVLTNADGTLAGVLTRT
MAV_2872|M.avium_104                VRDVAMTDFVVAPVGTEPRKIFDLLEQA-PIGVAVVTNADGTLAGVLTRT
MMAR_2717|M.marinum_M               VRDIAALDFVSAPVGTEPRKVFDLLEHS-PIEVAVLTRPDGTLAGVLSRT
MUL_3036|M.ulcerans_Agy99           VRDIAALDFVSAPVGTEPRKVFDLLEHS-PIEVAVLTRPDGTLAGVLSRT
TH_2384|M.thermoresistible__bu      VREVAVGEFVSAPVGTAPRKVFDLIEHAQPFDLAVMTASDGTLAGVLTRR
MSMEG_3634|M.smegmatis_MC2_155      VRDIALSDFVTAPVGTDPREVFDLLEHA-PIDVAVMTAPDGTLAGVLTRT
MAB_2412c|M.abscessus_ATCC_199      VHDIAATDFVTVPTGTDPRAIFDRLSEA-HVPVAVLTRPDGTMAGILTRT
                                    * ::.  ::* .*.** ** :** :..:  . :**:* .**::**:*:* 

Mflv_3360|M.gilvum_PYR-GCK          GAVRAGIYTPAVDAHGRLRIATAVGINGDVAAKARDLVEAGADLLVIDTA
Mvan_3090|M.vanbaalenii_PYR-1       GAVRAGIYTPAVDADGRLRIAAAVGINGDVGAKARDLAEAGVDVLVIDTA
Mb1874c|M.bovis_AF2122/97           GAIRAGIYTPATDSAGRLRIGAAVGINGDVGAKARALAEAGVDVLVIDTA
Rv1843c|M.tuberculosis_H37Rv        GAIRAGIYTPATDSAGRLRIGAAVGINGDVGAKARALAEAGVDVLVIDTA
MLBr_02066|M.leprae_Br4923          GAIRAGIYTPATDARGRLRIGAAVGINGDVAGKAQSLAEAGVDVLVVDTA
MAV_2872|M.avium_104                GAVRAGLYTPAVDAQGRLRVGAAIGINGDVGAKARSLVEAGIDLLVIDTA
MMAR_2717|M.marinum_M               GAIRAGIYTPATDAAGRLRIAAAVGINGDVAAKAGALAESGVDLLVIDTA
MUL_3036|M.ulcerans_Agy99           GAIRAGIYTPATDAAGRLRIAAAVGINGDVAAKAGALAESGVDLLVIDTA
TH_2384|M.thermoresistible__bu      GALRAEIYTPATDAQGRLRVAAAVGINGDVAAKAKALADTGIDLLVIDTA
MSMEG_3634|M.smegmatis_MC2_155      GAIRAGIYTPAVDAKGRLRIAAAVGINGDVGAKAQALAEAGADLLVIDTA
MAB_2412c|M.abscessus_ATCC_199      GAIRAGLYTPAVDDNGRLRVAGAVGINGDVRAKASALVQAGVDLLVIDTA
                                    **:** :****.*  ****:. *:****** .**  *.::* *:**:***

Mflv_3360|M.gilvum_PYR-GCK          HGHQRKMLDAIAAVAAADLGVPLAAGNVVSATGTRDLINAGATIVKVGVG
Mvan_3090|M.vanbaalenii_PYR-1       HGHQQKMLDTVEAVAALELGLPLVAGNVVSAEGTRDLISAGASIVKVGVG
Mb1874c|M.bovis_AF2122/97           HGHQVKTLDAIKAVSALDLGLPLAAGNVVSAEGTRDLLKAGANVVKVGVG
Rv1843c|M.tuberculosis_H37Rv        HGHQVKTLDAIKAVSALDLGLPLAAGNVVSAEGTRDLLKAGANVVKVGVG
MLBr_02066|M.leprae_Br4923          HGYQVKTLEAIKCVASLNLGVPLVAGNVVSAEGTRELLNAGATIVKVGVG
MAV_2872|M.avium_104                HGHQVKTLEAIRTVASLELGVPLVAGNVVSADGTRDLLGAGANIVKVGVG
MMAR_2717|M.marinum_M               HGHQVKTLDAISAVASLDLGLPLAAGNVVSAEGTRDLLGAGADIVKVGVG
MUL_3036|M.ulcerans_Agy99           HGHQVKTLDAISAVASLDLGLPLAAGNVVSAEGTRDLLGAGADIVKVGVG
TH_2384|M.thermoresistible__bu      HGHQIRMVEAVRAVAALGLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVG
MSMEG_3634|M.smegmatis_MC2_155      HGHQAKMLDAIKAVASLDLGLPLVAGNVVSAEGTRDLIEAGASIVKVGVG
MAB_2412c|M.abscessus_ATCC_199      HGHQQKMLDVLAAVAELSLGVPIAAGNVVSAQGTRDLIRAGADIVKVGVG
                                    **:* : ::.:  *:   **:*:.******* ***:*: *** :******

Mflv_3360|M.gilvum_PYR-GCK          PGAMCTTRMMTGVGRPQFSAVVECASAAKELGGHVWADGGVRHPRDVALA
Mvan_3090|M.vanbaalenii_PYR-1       PGAMCTTRMMTGVGRPQFSAVVECAAAARELGGHVWADGGVRHPRDVALA
Mb1874c|M.bovis_AF2122/97           PGAMCTTRMMTGVGRPQFSAVLECASAARQLGGHIWADGGIRHPRDVALA
Rv1843c|M.tuberculosis_H37Rv        PGAMCTTRMMTGVGRPQFSAVLECASAARQLGGHIWADGGIRHPRDVALA
MLBr_02066|M.leprae_Br4923          PGAMCTTRMMTGVGRPQFSAVLECASAARKLNRHVWADGGVRHPRDVALA
MAV_2872|M.avium_104                PGAMCTTRMMTGVGRPQFSAVVECASAARELGGHVWADGGIRHPRDVALA
MMAR_2717|M.marinum_M               PGAMCTTRMMTGVGRPQFSAVLECSAAARELGGHVWADGGIRHPRDVALA
MUL_3036|M.ulcerans_Agy99           PGAMCTTRMMTGVGRPQFSAVLECSAAARELGGHVWADGGIRHPRDVALA
TH_2384|M.thermoresistible__bu      PGAMCTTRMMTGVGRPQFSAVLECAAAARELGAHVWADGGVRHPRDVALA
MSMEG_3634|M.smegmatis_MC2_155      PGAMCTTRMMTGVGRPQFSAVVECAAAARQLGGHVWADGGVRHPRDVALA
MAB_2412c|M.abscessus_ATCC_199      PGAMCTTRMMTGVGRPQLSAVIECAAAARELGAHVWADGGVRHPRDVALA
                                    *****************:***:**::**::*. *:*****:*********

Mflv_3360|M.gilvum_PYR-GCK          LAAGASNVMIGSWFAGTYESPGDLMHDRDGLPYKESYGMASKRAVAARTA
Mvan_3090|M.vanbaalenii_PYR-1       IAAGASNVMIGSWFAGTYESPGDLMRDRDDQPYKESYGMASKRAVAARTA
Mb1874c|M.bovis_AF2122/97           LAAGASNVMIGSWFAGTYESPGDLMRDRDDQPYKESYGMASKRAVVARTG
Rv1843c|M.tuberculosis_H37Rv        LAAGASNVMIGSWFAGTYESPGDLMRDRDDQPYKESYGMASKRAVVARTG
MLBr_02066|M.leprae_Br4923          LAAGASNVMIGSWFAGTYESPGDLMRDRHDQPYKESYGMASKRAVVARTV
MAV_2872|M.avium_104                LAAGASNVMIGSWFAGTYESPGDLMRDREDQPYKESYGMASKRAVVARSG
MMAR_2717|M.marinum_M               LAAGASNVMIGSWFAGTYESPGDLMRDREDQPYKESYGMASKRAVVARTT
MUL_3036|M.ulcerans_Agy99           LAAGASNVMIGSWFAGTYESPGDLMRDREDQPYKESYGMASKRAVVARTT
TH_2384|M.thermoresistible__bu      LAAGASNVMIGSWFAGTYESPGDLMRDRDDRPYKESYGMASKRAVTARTA
MSMEG_3634|M.smegmatis_MC2_155      LAAGASNVMIGSWFAGTYESPGDLLFDRDDRPYKESYGMASKRAVAARTA
MAB_2412c|M.abscessus_ATCC_199      LAAGAANVMIGSWFAGTHESPGDLQLSPTGRRYKDSFGMASKRAVAARTA
                                    :****:***********:******  .  .  **:*:********.**: 

Mflv_3360|M.gilvum_PYR-GCK          GDSAFDRARKGLFEEGISTSRMDLDPVRGGVEDLLDHITSGVRSTCTYVG
Mvan_3090|M.vanbaalenii_PYR-1       GDSSFDRARKALFEEGISSSRMYLDPVRGGVEDLIDHITSGVRSTCTYVG
Mb1874c|M.bovis_AF2122/97           ADNPFDRARKALFEEGISTSRMGLDPDRGGVEDLIDHITSGVRSTCTYVG
Rv1843c|M.tuberculosis_H37Rv        ADNPFDRARKALFEEGISTSRMGLDPDRGGVEDLIDHITSGVRSTCTYVG
MLBr_02066|M.leprae_Br4923          ADSSFDRARKALFDEGISTSRMGLDPDHGGVEDLIDHITSGVRSTCTYVG
MAV_2872|M.avium_104                AETAFDRARKSLFEEGISTSRMGLDPARGGVEDLIDHITSGVRSTCTYVG
MMAR_2717|M.marinum_M               TDSAFDRARKSLFEEGISTSRMGLDPDRGGVEDLIDHITSGVRSTCTYVG
MUL_3036|M.ulcerans_Agy99           TDSAFDRARKSLFEEGISTSRMGLDLDRGGVEDLIDHITSGVRSTCTYVG
TH_2384|M.thermoresistible__bu      ADSPFDRARKALFEEGISTSRMGLDPSRGGVEDLLDHITAGLRSTCTYVG
MSMEG_3634|M.smegmatis_MC2_155      GDSSFDRARKGLFEEGISTSRMSLDPARGGVEDLLDHITSGVRSTCTYVG
MAB_2412c|M.abscessus_ATCC_199      GDSAFDQARKSLFEEGISTSRIELDPQRPGVEDLIDHIISGVRSTCTYVG
                                     :..**:***.**:****:**: **  : *****:*** :*:********

Mflv_3360|M.gilvum_PYR-GCK          AATLPELHDKAVLGVQSAAGFAEGHPLPTGW
Mvan_3090|M.vanbaalenii_PYR-1       ATTLSELHEKAVVGVQSAAGFAEGHPLPTGW
Mb1874c|M.bovis_AF2122/97           ASNLAELHERAVVGVQSGAGFAEGHPLPAGW
Rv1843c|M.tuberculosis_H37Rv        ASNLAELHERAVVGVQSGAGFAEGHPLPAGW
MLBr_02066|M.leprae_Br4923          ASTLAELHEKAVVGVQSAAGFAEGHPLPSGW
MAV_2872|M.avium_104                AATLAQLYERVVVGVQSTAGFAEGHPLPLGW
MMAR_2717|M.marinum_M               ASNLAELHEQVVIGVQSAAGFAEGHPLPAGW
MUL_3036|M.ulcerans_Agy99           ASNLAELHEQVVIGVQSAAGFAEGHPLPAGW
TH_2384|M.thermoresistible__bu      AATLPELHEKAVLGVQSQAGFAEGHPLPEGW
MSMEG_3634|M.smegmatis_MC2_155      AANLPELHEKVVLGVQSAAGFAEGHPLPAGW
MAB_2412c|M.abscessus_ATCC_199      ARTLGELHERVVLGVQSAAGFAEGRPLPEGW
                                    * .* :*:::.*:**** ******:*** **