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M. thermoresistible (build 8) TH_2311 (thiE)

annotation: PROBABLE THIAMINE-PHOSPHATE PYROPHOSPHORYLASE THIE (TMP PYROPHOSPHORYLASE) (TMP-PPASE) (THIAMINE-PHOSPHATE SYNTHASE)
coordinates: 4531985 - 4532644
length: 220

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_2311 thiE - 100% (220) PROBABLE THIAMINE-PHOSPHATE PYROPHOSPHORYLASE THIE (TMP PYROPHOSPHORYLASE) (TMP-PPASE) (THIAMINE-PHOSPHATE SYNTHASE)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0422c thiE 8e-86 74.30% (214) thiamine-phosphate pyrophosphorylase
M. gilvum PYR-GCK Mflv_0198 thiE 8e-92 78.40% (213) thiamine-phosphate pyrophosphorylase
M. tuberculosis H37Rv Rv0414c thiE 8e-86 74.30% (214) thiamine-phosphate pyrophosphorylase
M. leprae Br4923 MLBr_00300 thiE 3e-84 72.69% (216) thiamine-phosphate pyrophosphorylase
M. abscessus ATCC 19977 MAB_4219 thiE 3e-85 73.33% (210) thiamine-phosphate pyrophosphorylase
M. marinum M MMAR_0717 thiE 1e-86 76.53% (213) thiamine-phosphate pyrophosphorylase ThiE
M. avium 104 MAV_4748 thiE 4e-93 79.26% (217) thiamine-phosphate pyrophosphorylase
M. smegmatis MC2 155 MSMEG_0789 thiE 5e-97 82.16% (213) thiamine-phosphate pyrophosphorylase
M. ulcerans Agy99 MUL_2806 thiE 8e-87 76.53% (213) thiamine-phosphate pyrophosphorylase
M. vanbaalenii PYR-1 Mvan_0707 thiE 4e-97 81.22% (213) thiamine-phosphate pyrophosphorylase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0422c|M.bovis_AF2122/97           ----------------MHES----------RLASARLYLCTDARRERGDL
Rv0414c|M.tuberculosis_H37Rv        ----------------MHES----------RLASARLYLCTDARRERGDL
MLBr_00300|M.leprae_Br4923          ----------------MQEPHRQPAICLSTRLAKARLYLCTDARRERGDL
MMAR_0717|M.marinum_M               ----------------MHSR-----------LATARLYLCTDARRERGDL
MUL_2806|M.ulcerans_Agy99           ----------------MHSR-----------LATARLYLCTDARRERGDL
MAV_4748|M.avium_104                ----------------MHQR--------LATLAAARLYLCTDARRERGDL
TH_2311|M.thermoresistible__bu      -------------------------------LSAASLYLCTDARRERGDL
MSMEG_0789|M.smegmatis_MC2_155      -----------MDQAVELPV---------QRLQRASLYLCTDARRERGDL
Mflv_0198|M.gilvum_PYR-GCK          MWSRSSLRRLTATVSTVPES---------PSLQGARLYLCTDARRERGDL
Mvan_0707|M.vanbaalenii_PYR-1       ----------------MRES---------RKLDSAALYLCTDARRERGDL
MAB_4219|M.abscessus_ATCC_1997      ----------------MHSR--------SARLQSAHLYLCTDARRERGDF
                                                                   *  * *************:

Mb0422c|M.bovis_AF2122/97           AQFAEAALAGGVDIIQLRDKGSPGELRFGPLQARDELAACEILADAAHRY
Rv0414c|M.tuberculosis_H37Rv        AQFAEAALAGGVDIIQLRDKGSPGELRFGPLQARDELAACEILADAAHRY
MLBr_00300|M.leprae_Br4923          AQFVNAALAGGVDIVQLRDKGSVGEQQFGPLEARDALAACEIFTDATGRH
MMAR_0717|M.marinum_M               ADFADAALAGGVDIIQLRDKGSAGEQRFGPLEARDELAACEILADAAARH
MUL_2806|M.ulcerans_Agy99           ADFADAALAGGVDIIQLRDKGSAGEQRFGPLEARDELAACEILADAAARH
MAV_4748|M.avium_104                AEFADAALAGGVDVIQLRDKGSPGEQRFGPLEARDELAACEILADAARRH
TH_2311|M.thermoresistible__bu      AEFADAALAGGVDLIQLRDKGSPGEQRFGPLEARDELEALSVLADAARRH
MSMEG_0789|M.smegmatis_MC2_155      AEFADAALAGGVDLIQLRDKGSAGEKQFGPLEARQELEALEILADAARRH
Mflv_0198|M.gilvum_PYR-GCK          ADFADAALAGGVDIIQLRDKGSPGEKAFGPLEARAEIDALHVLAEAARRH
Mvan_0707|M.vanbaalenii_PYR-1       AEFADAALAGGVDIIQLRDKGSAGEQRFGPLEAREEIEVLATLADAARRH
MAB_4219|M.abscessus_ATCC_1997      AEFVDAALAGGVDIVQLRDKGSAGERQFGRLEPAEELEYLAILSEAAARH
                                    *:*.:********::******* **  ** *:.   :     :::*: *:

Mb0422c|M.bovis_AF2122/97           GALFAVNDRADIARAAGADVLHLGQRDLPVNVARQILAPDTLIGRSTHDP
Rv0414c|M.tuberculosis_H37Rv        GALFAVNDRADIARAAGADVLHLGQRDLPVNVARQILAPDTLIGRSTHDP
MLBr_00300|M.leprae_Br4923          DALFAVNDRADIARAAGADVLHLGQGDLPPGVARQIVCRQMLIGLSTHDR
MMAR_0717|M.marinum_M               AAMFAVNDRADIARAARADVLHLGQRDLPVDVARAITGPATLIGQSTHDR
MUL_2806|M.ulcerans_Agy99           AAMFAVNDRADIARAARADVLHLGQRDLPVDVARAITGPATLIGQSTHDR
MAV_4748|M.avium_104                GALFAVNDRADIARAAGADVLHLGQGDLPLDVARAFVGPDVLLGLSSHDR
TH_2311|M.thermoresistible__bu      DALLAVNDRADVALAAGADVLHLGQDDLPLPVARRIVGDEVLIGRSTHDI
MSMEG_0789|M.smegmatis_MC2_155      GALLAVNDRADIALAAGADVLHLGQDDLPLDVARGIIGRRPVIGRSTHDA
Mflv_0198|M.gilvum_PYR-GCK          NALVAVNDRADIARASGAEVLHLGQDDLPLTVARQIVGDR-VIGRSTHDL
Mvan_0707|M.vanbaalenii_PYR-1       GALFAVNDRADIALAADADVLHLGQDDLPLTVARRIVGDR-IVGRSTHDL
MAB_4219|M.abscessus_ATCC_1997      GALFAVNDRADIARAAGADVLHLGQDDLPLAVAREIVGPDVLIGRSTHDA
                                     *:.*******:* *: *:****** ***  *** :     ::* *:** 

Mb0422c|M.bovis_AF2122/97           DQVAAAAAG-DA---DYFCVGPCWPTPTKPGRAAPGLGLVRVAAELGGDD
Rv0414c|M.tuberculosis_H37Rv        DQVAAAAAG-DA---DYFCVGPCWPTPTKPGRAAPGLGLVRVAAELGGDD
MLBr_00300|M.leprae_Br4923          HQVAAAVAALDAGLVDYFCVGPCWPTPTKPDRPAPGLELVRAAAELAGD-
MMAR_0717|M.marinum_M               DQVSAAAIG----AVDYFCVGPCWPTPTKPGRTAPGLDLVRFAADVAGA-
MUL_2806|M.ulcerans_Agy99           DQVSAAAIG----AVDYFCVGPCWPTPTKPGRTAPGLDLVRFAADVAGA-
MAV_4748|M.avium_104                DQMTAAAAG----PADYFCVGPCWPTPTKPGRAAPGLALVRAAAELRTG-
TH_2311|M.thermoresistible__bu      EQVRTAIADRD---VDYFCVGPCWPTPTKPGRPAPGLDLVRAAAAEGTG-
MSMEG_0789|M.smegmatis_MC2_155      AQMAVAIEER----VDYFCVGPCWPTPTKPGRPAPGLDLVRATAAHSPG-
Mflv_0198|M.gilvum_PYR-GCK          AQAEAAIAED----VDYFCVGPCWPTPTKPGRAAPGLDLVREVAALNTT-
Mvan_0707|M.vanbaalenii_PYR-1       DQVRAAVGED----VNYFCVGPCWPTPTKPGRPAPGLDLIRATAALGTD-
MAB_4219|M.abscessus_ATCC_1997      EQAAAAARDDE---IDYFCCGPCWPTPTKPGRTASGLGLVRTAAELDTS-
                                     *  .*         :*** **********.*.*.** *:* .*      

Mb0422c|M.bovis_AF2122/97           KPWFAIGGINAQRLPAVLDAGARRIVVVRAITSADDPRAAAEQLRSALTA
Rv0414c|M.tuberculosis_H37Rv        KPWFAIGGINAQRLPAVLDAGARRIVVVRAITSADDPRAAAEQLRSALTA
MLBr_00300|M.leprae_Br4923          KPWFAIGGIDAQRLPDVLHAGARRIVVVRAITAAADPRAAAEQLISTLTA
MMAR_0717|M.marinum_M               KPWFAIGGIDGVRLPEVLAAGARRIVVVRAITAADDPREAAAKLKSELLA
MUL_2806|M.ulcerans_Agy99           KPWFAIGGIDGLRLPEVLAAGARRIVVVRAITAADDPREAAAKLKSELLA
MAV_4748|M.avium_104                KPWFAIGGIDAQRLPEVLDAGARRVVVVRAITAADDPAAAARRLSSALAA
TH_2311|M.thermoresistible__bu      KPWFAIGGIDEQRLPEVVAAGARRIVVVRAITAADDPEAAARRLKAMLPG
MSMEG_0789|M.smegmatis_MC2_155      KPWFAIGGIDQERLPEVLAAGARRVVVVRAITAADDPKAAAEDLKAAISA
Mflv_0198|M.gilvum_PYR-GCK          KPWFAIGGIDAQRLPDVLDAGARRVVVVRAITAAEDPRAAAEQLAGMLDS
Mvan_0707|M.vanbaalenii_PYR-1       KPWFAIGGIDAERLPEVLDAGARRVVVVRAITAADDPGAAAQRLAGMLSA
MAB_4219|M.abscessus_ATCC_1997      KPWFAIGGIDEARVPQVVEAGASRIVVVRAITAAADPRAAAASLRGSTRR
                                    *********:  *:* *: *** *:*******:* **  **  * .    

Mb0422c|M.bovis_AF2122/97           AN--
Rv0414c|M.tuberculosis_H37Rv        AN--
MLBr_00300|M.leprae_Br4923          TS--
MMAR_0717|M.marinum_M               AI--
MUL_2806|M.ulcerans_Agy99           AI--
MAV_4748|M.avium_104                AR--
TH_2311|M.thermoresistible__bu      GRTG
MSMEG_0789|M.smegmatis_MC2_155      AG--
Mflv_0198|M.gilvum_PYR-GCK          AV--
Mvan_0707|M.vanbaalenii_PYR-1       AG--
MAB_4219|M.abscessus_ATCC_1997      A---

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_2311	thiE	-	100% (220)	PROBABLE THIAMINE-PHOSPHATE PYROPHOSPHORYLASE THIE (TMP PYROPHOSPHORYLASE) (TMP-PPASE) (THIAMINE-PHOSPHATE SYNTHASE)