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M. thermoresistible (build 8) TH_2241 (otsA)

annotation: PROBABLE ALPHA, ALPHA-TREHALOSE-PHOSPHATE SYNTHASE
coordinates: 4376520 - 4377980
length: 487

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2241otsA-100% (487)PROBABLE ALPHA, ALPHA-TREHALOSE-PHOSPHATE SYNTHASE

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3520otsA0.079.88% (482) alpha,alpha-trehalose-phosphate synthase
M. gilvum PYR-GCKMflv_1566-0.080.63% (475) Alpha,alpha-trehalose-phosphate synthase (UDP-forming)
M. tuberculosis H37RvRv3490otsA0.079.88% (482) alpha,alpha-trehalose-phosphate synthase
M. leprae Br4923MLBr_02254otsA0.080.00% (480) putative trehalose-phosphate synthase
M. abscessus ATCC 19977MAB_4145-0.080.29% (477) alpha,alpha-trehalose-phosphate synthase
M. marinum MMMAR_4978otsA0.082.74% (481) alpha, alpha-trehalose-phosphate synthase
M. avium 104MAV_0666otsA0.083.86% (477) UDP-forming alpha,alpha-trehalose-phosphate synthase
M. smegmatis MC2 155MSMEG_5892-0.084.45% (476) alpha,alpha-trehalose-phosphate synthase (UDP-forming)
M. ulcerans Agy99MUL_4052otsA0.082.54% (481) alpha, alpha-trehalose-phosphate synthase
M. vanbaalenii PYR-1Mvan_5192-0.080.84% (475) Alpha,alpha-trehalose-phosphate synthase (UDP-forming)

CLUSTAL 2.0.9 multiple sequence alignment


Mb3520|M.bovis_AF2122/97            MAPSGGQEAQICDSET---FGDSDFVVVANRLPVDLERLPDGSTTWKRSP
Rv3490|M.tuberculosis_H37Rv         MAPSGGQEAQICDSET---FGDSDFVVVANRLPVDLERLPDGSTTWKRSP
MMAR_4978|M.marinum_M               MGPGGRQSAEPASTEV---FGDSDFVVVANRLPVDQERLPDGTIAWKRSP
MUL_4052|M.ulcerans_Agy99           MGPGGRQSAEPASTEV---FGDSDFVVVANRLPVDQERLPDGTIAWKRSP
MAV_0666|M.avium_104                MAPGGGRGSKTAS------YGNSDFVVVANRLPVDQERLPDGSTAWKRSP
MLBr_02254|M.leprae_Br4923          MTSRGNHGSKTSSDKH---LGDSDFVVVANRLPVDQVRLPDGTAIWKRSP
Mflv_1566|M.gilvum_PYR-GCK          MTDQSGNGVRSGSASEAPPSAKADFVVVANRLPIDQVNLPDGSTEWKRSP
Mvan_5192|M.vanbaalenii_PYR-1       MAPQSGPEARSG---------GADFVVVANRLPIDMVRRADGTTEFKRSP
MSMEG_5892|M.smegmatis_MC2_155      MSPESGHETISG---------TSDFVVVANRLPVDLERLPDGTTRWKRSP
TH_2241|M.thermoresistible__bu      MADRGDSG-------------DSDFVVVANRLPIDLERAPDGTTSWKRSP
MAB_4145|M.abscessus_ATCC_1997      MATQSDERSPVKPVTG-----TSDFVVVANRLPIDLVKLPDGSTTWKRSP
                                    *   .                 :**********:*  . .**:  :****

Mb3520|M.bovis_AF2122/97            GGLVTALEPVLRRRRGAWVGWPGVNDDGAEPDLHVLDGPIIQDELELHPV
Rv3490|M.tuberculosis_H37Rv         GGLVTALEPVLRRRRGAWVGWPGVNDDGAEPDLHVLDGPIIQDELELHPV
MMAR_4978|M.marinum_M               GGLVTALEPLLRRRRGAWVGWAGVVEN----DVDVQDEPIVQDELQLQPV
MUL_4052|M.ulcerans_Agy99           GGLVTALEPLLRRRRGAWVGWAGVVEN----DVDVQDEPIVQDELQLQPV
MAV_0666|M.avium_104                GGLVTALEPLLRRQRGAWVGWPGIVDE----DVDHEDDPIVQDDLELRPV
MLBr_02254|M.leprae_Br4923          GGLVTALEPLLRQRRGAWVGWPGVINDN--VDLDLTIKSIVQDGLTLYPV
Mflv_1566|M.gilvum_PYR-GCK          GGLVTALEPLLRRRHGAWIGWPGVPEDA--DDPDASTEPIEQDGMTLVPV
Mvan_5192|M.vanbaalenii_PYR-1       GGLVTALEPLLRRRHGAWIGWPGVPEDA--DDPNAATEPIEQDGMTLVPV
MSMEG_5892|M.smegmatis_MC2_155      GGLVTALEPLLRKRRGSWIGWAGVADSD--E------EPIVQDGLQLHPV
TH_2241|M.thermoresistible__bu      GGLVTALEPLLRRRRGAWIGWPGIPDSD--------EDPIVDGDLVLYPV
MAB_4145|M.abscessus_ATCC_1997      GGLVTAMEPLLRKRRGAWVGWPGVPDAD--------VEPVSEDDMVLYSV
                                    ******:**:**:::*:*:**.*: :            .: :. : * .*

Mb3520|M.bovis_AF2122/97            RLSTTDIAQYYEGFSNATLWPLYHDVIVKPLYHREWWDRYVDVNQRFAEA
Rv3490|M.tuberculosis_H37Rv         RLSTTDIAQYYEGFSNATLWPLYHDVIVKPLYHREWWDRYVDVNQRFAEA
MMAR_4978|M.marinum_M               RLSADDVAQYYEGFSNATLWPLYHDVIVRPIYHREWWDRYVDVNRRFAEA
MUL_4052|M.ulcerans_Agy99           RLSADDVAQYYEGFSNATLWPLYHDVIVRPIYHREWWDRYVDVNRRFAEA
MAV_0666|M.avium_104                KLSADDVAEYYEGFSNATLWPLYHDVIVKPIYHREWWDRYVAVNRRFAEA
MLBr_02254|M.leprae_Br4923          RLNTHDVAEYYEGFSNATLWPLYHDVIVKPIYHCEWWERYVDVNRRFAET
Mflv_1566|M.gilvum_PYR-GCK          RLSAADVAKYYEGFSNATLWPLYHDVIVKPTYHREWWERYVEVNRRFAEA
Mvan_5192|M.vanbaalenii_PYR-1       RLSSEDVAEYYEGFSNATLWPLYHDVIVKPIYHREWWDRYVDVNRRFAEA
MSMEG_5892|M.smegmatis_MC2_155      RLSADDVAKYYEGFSNATLWPLYHDLIVKPEYHREWWDRYVEVNRRFAEA
TH_2241|M.thermoresistible__bu      RLSADDVAQYYEGFSNATLWPLYHDVIVKPIYNRQWWERYVEVNRRFAEA
MAB_4145|M.abscessus_ATCC_1997      RLSTQEVAEYYEGFSNATLWPLYHDVIVKPEYHREWWQAYVDVNRKFAEA
                                    :*.: ::*:****************:**:* *: :**: ** **::***:

Mb3520|M.bovis_AF2122/97            ASRAAAHGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQ
Rv3490|M.tuberculosis_H37Rv         ASRAAAHGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQ
MMAR_4978|M.marinum_M               TARAAARGGTVWVQDYQLQLVPKMLRAMRPDLTIGFFLHIPFPPVELFMQ
MUL_4052|M.ulcerans_Agy99           TARAAARGGTVWVQDYQLQLVPKMLRAMRPDLTIGFFLHIPFPPVELFMQ
MAV_0666|M.avium_104                TSRAAARGATVWVQDYQLQLVPAMLRELRPDLTIGFFLHIPFPPVELFMQ
MLBr_02254|M.leprae_Br4923          TSRTAAYGGTVWVQDYQLQLVPKMLRIMRPDLTIGFFLHIPFPPVELFMQ
Mflv_1566|M.gilvum_PYR-GCK          AARTAAEGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFLQ
Mvan_5192|M.vanbaalenii_PYR-1       TAHTAAEGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQ
MSMEG_5892|M.smegmatis_MC2_155      TARAAAEGATVWIQDYQLQLVPKMLRMLRPDVTIGFFLHIPFPPVELFMQ
TH_2241|M.thermoresistible__bu      TSRAAARGATVWVQDYQLQLVPKMLRELRPDLTIGFFLHIPFPPVELFMQ
MAB_4145|M.abscessus_ATCC_1997      TAAVAAEGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQ
                                    :: .** *.***:********* *** :***:****************:*

Mb3520|M.bovis_AF2122/97            MPWRTEIIQGLLGADLVGFHLPGGAQNFLILSRRLVGTDTSRGTVGVRSR
Rv3490|M.tuberculosis_H37Rv         MPWRTEIIQGLLGADLVGFHLPGGAQNFLILSRRLVGTDTSRGTVGVRSR
MMAR_4978|M.marinum_M               LPWRTEIIQGLLGADLVGFHLPGGAQNFLILSRRLVGADTSRGTVGVRSR
MUL_4052|M.ulcerans_Agy99           LPWRTEIIQGLLGADLVGFHLPGGAQNFLILSRRLVGADTSRGTVGVRSR
MAV_0666|M.avium_104                LPWRTEIVKGLLGADLVGFHLTGGAQNFLFLSRRLIGANTSRGAVGVRSR
MLBr_02254|M.leprae_Br4923          IPWRTEIIEGLLGADLVGFHLTSGAQNFLFLSRHLLGANTSRGLVGVRSR
Mflv_1566|M.gilvum_PYR-GCK          MPWRTEIIEGLLGADLVGFHLPGGAQNFLILARRLLGAVTSRGNVGVRSR
Mvan_5192|M.vanbaalenii_PYR-1       MPWRTEIIEGLLGADLVGFHLPGGAQNFLILARRLIGATTSRGNVGVRSR
MSMEG_5892|M.smegmatis_MC2_155      MPWRTEIVEGLLGADLVGFHLPGGAQNFLVLSRRLVGANTSRASIGVRSR
TH_2241|M.thermoresistible__bu      LPWRTEITDGLLGADLVGFHLPGGAQNFLFLARRLVGANTSRASVGVRSK
MAB_4145|M.abscessus_ATCC_1997      MPWRTEIVDGLLGADLIGFHLAGGAQNFMYLARRLVGASTSRASIGVRSR
                                    :****** .*******:****..*****: *:*:*:*: ***. :****:

Mb3520|M.bovis_AF2122/97            FGAAVLGSRTIRVGAFPISVDSGALDHAARDRNIRRRAREIRTELGNPRK
Rv3490|M.tuberculosis_H37Rv         FGAAVLGSRTIRVGAFPISVDSGALDHAARDRNIRRRAREIRTELGNPRK
MMAR_4978|M.marinum_M               FGEVILGSRTIRVGAFPISIDSGALDQTARDRNIRRRSREIRAELGNPRK
MUL_4052|M.ulcerans_Agy99           FGEVILGSRTIRVGAFPISIDSGALDQTARDRNIRRRSREIRAELGNPRK
MAV_0666|M.avium_104                YGEVELESRVVRVGAFPISIDSTALDQTARHRDIRRRAREIRAELGNPRK
MLBr_02254|M.leprae_Br4923          FGEVQLKSHTVQVGAFPISIDSKEIDQATRDRNVRRRAREIRAELGNPRK
Mflv_1566|M.gilvum_PYR-GCK          FGEVQFGFRKVKVGAFPISIDSAELDQHARTRATRQRAKEIRAELGNPRK
Mvan_5192|M.vanbaalenii_PYR-1       FGEVQFGFRTVKVGAFPISIDSAELDQHARSRATRQRAKEIRAELGNPRK
MSMEG_5892|M.smegmatis_MC2_155      FGEVQVGFRTVKVGAFPISIDSAELDGKARNRAIRQRARQIRAELGNPRK
TH_2241|M.thermoresistible__bu      FGEVQIGSRTVKVGAFPISIDSADLDRQARQRSIRQRARQIRAELGNPRR
MAB_4145|M.abscessus_ATCC_1997      FGEIRVGFRTVKVGAFPISIDSTQLDSVSRSRQIRQRAKEIRAELGGPRK
                                    :*   .  : ::*******:**  :*  :* *  *:*:::**:***.**:

Mb3520|M.bovis_AF2122/97            ILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVLVQLATPSRERVES
Rv3490|M.tuberculosis_H37Rv         ILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVVVQLATPSRERVES
MMAR_4978|M.marinum_M               ILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVLVQLATPSRERVES
MUL_4052|M.ulcerans_Agy99           ILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVLVQLATPSRERVES
MAV_0666|M.avium_104                VLLGVDRLDYTKGIDVRLKAFSELLAEGRAKRDDTVLVQLATPSRERVDS
MLBr_02254|M.leprae_Br4923          ILLGVDRLDYTKGIDVRLRAFAELLAEGRAKRDDTVLVQLATPSRERVES
Mflv_1566|M.gilvum_PYR-GCK          VLLGVDRLDYTKGIDVRLRAFSELLEEGRIDPEDTVLVQLATPSRERVQS
Mvan_5192|M.vanbaalenii_PYR-1       ILLGVDRLDYTKGIDVRLRAFSELLEEGRIDPEDTVLVQLATPSRERVES
MSMEG_5892|M.smegmatis_MC2_155      IMLGVDRLDYTKGIDVRLRALSELLEEKRIKRDDTVLVQLATPSRERVES
TH_2241|M.thermoresistible__bu      ILLGVDRLDYTKGIDVRLQAFAELLAEGRVNREDTVFVQLATPSRERVEA
MAB_4145|M.abscessus_ATCC_1997      ILLGVDRLDYTKGIDIRLHAYEELLAEGRASREDTVFVQLATPSRERVDS
                                    ::*************:**:*  *** * * . :***.***********::

Mb3520|M.bovis_AF2122/97            YQTLRNDIERQVGHINGEYGEVGHPVVHYLHRPAPRDELIAFFVASDVML
Rv3490|M.tuberculosis_H37Rv         YQTLRNDIERQVGHINGEYGEVGHPVVHYLHRPAPRDELIAFFVASDVML
MMAR_4978|M.marinum_M               YQTLRNDIERQVGHINGEYAEVGHPVVHYLHRPVPRNELIAFFVASDVML
MUL_4052|M.ulcerans_Agy99           YQTLRNDIERQVGHINGEYAEVGHPVVHYLHRPVPRNELIAFFVASDVML
MAV_0666|M.avium_104                YQQLRNDIERQVGHINGEYGEVGHPVVHYLHRPVPRNELIAFFVAADVML
MLBr_02254|M.leprae_Br4923          YKILRNDIERQVGHINGEYGEVGHPVVHYLHRPIPRDELIAFYVASDVML
Mflv_1566|M.gilvum_PYR-GCK          YIEMREDIERQVGHVNGEFGKVGHPVLHYLHRPIPREDLVAFFVAADVML
Mvan_5192|M.vanbaalenii_PYR-1       YVAMREDIERQVGHVNGEFGEVGHPVLHYLHRPIPREDLVAFFVAADVML
MSMEG_5892|M.smegmatis_MC2_155      YIAMREDIERQVGHINGEYGEVGHPIVHYLHRPIPRDELIAFFVAADVML
TH_2241|M.thermoresistible__bu      YRLLRDDIERQVGHINGEYGEVGHPVVHYLHRPVPREELIAFFVAADVML
MAB_4145|M.abscessus_ATCC_1997      YKKMRGDVEQQVGHINGEFGEVGHPVVHYLHRPVPREDLIAFFVAADVML
                                    *  :* *:*:****:***:.:****::****** **::*:**:**:****

Mb3520|M.bovis_AF2122/97            VTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLE
Rv3490|M.tuberculosis_H37Rv         VTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLE
MMAR_4978|M.marinum_M               VTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLE
MUL_4052|M.ulcerans_Agy99           VTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLE
MAV_0666|M.avium_104                VTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRQAYLVNPHDLE
MLBr_02254|M.leprae_Br4923          VTPLRDGMNLVAKEYVACRNDLGGALVLSEFTGAAAELRQAYLVNPHDLE
Mflv_1566|M.gilvum_PYR-GCK          VTPLRDGMNLVAKEYVACRHDLGGALVLSEFTGAAAELRQAYLTNPHHLE
Mvan_5192|M.vanbaalenii_PYR-1       VTPLRDGMNLVAKEYVACRHDLGGALVLSEFTGAAAELRQAYLTNPHHIE
MSMEG_5892|M.smegmatis_MC2_155      VTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRQAYLVNPHDLE
TH_2241|M.thermoresistible__bu      VTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELGQAYLVNPHNLD
MAB_4145|M.abscessus_ATCC_1997      VTPLRDGMNLVAKEYVACRSDLGGSLVLSEFTGAAAELRQAYLVNPHDID
                                    ******************* ****:************* :***.***.::

Mb3520|M.bovis_AF2122/97            GVKDGIEEALNQTEEAGRRRMRSLRRQVLAHDVDRWAQSFLDALAGA---
Rv3490|M.tuberculosis_H37Rv         GVKDGIEEALNQTEEAGRRRMRSLRRQVLAHDVDRWAQSFLDALAGA---
MMAR_4978|M.marinum_M               GVKDGIEEALNQTEEAGRRRMRSMRRQVLAHDVDRWARSFLDALADS---
MUL_4052|M.ulcerans_Agy99           GVNDGIEEALNQTEEAGRRRMRSMRRQVLAHDVDRWARSFLDALADS---
MAV_0666|M.avium_104                GVKDTVEAALNQSVEEGRRRMRSLRRQVLAHDVDRWARSFLDALAES---
MLBr_02254|M.leprae_Br4923          GVKDTIEAALNQLAEEARRRMRSLRRQVLAHDVDRWARSFLDALAEA---
Mflv_1566|M.gilvum_PYR-GCK          GVKDAIEAALNQSPEEGRRRMRALRRQVLAHDVDRWARSFLDALASR---
Mvan_5192|M.vanbaalenii_PYR-1       GVKDAIEAALTQAPEEGRRRMRAMRRQVLAHDVDRWARSFLDALASK---
MSMEG_5892|M.smegmatis_MC2_155      GVKDKIEAAVNQNPEEGKRRMRALRRQVLAHDVDRWARSFLDALAATGET
TH_2241|M.thermoresistible__bu      HVKDTMVAALNQTPEEGRRRMRALRRQVLAHDVDLWARSFLDALAST---
MAB_4145|M.abscessus_ATCC_1997      GVKDGIESALNQTPEEGRRRMRALRRQVLAHDVDRWARAFLEALSTP---
                                     *:* :  *:.*  * .:****::********** **::**:**:     

Mb3520|M.bovis_AF2122/97            --HPRGQG-------------
Rv3490|M.tuberculosis_H37Rv         --HPRGQG-------------
MMAR_4978|M.marinum_M               --RPNDSADAAD---------
MUL_4052|M.ulcerans_Agy99           --RPNDSADAAD---------
MAV_0666|M.avium_104                --GPRDG--------------
MLBr_02254|M.leprae_Br4923          --PARDAT-------------
Mflv_1566|M.gilvum_PYR-GCK          --EPINEESH-----------
Mvan_5192|M.vanbaalenii_PYR-1       --EPVEG--------------
MSMEG_5892|M.smegmatis_MC2_155      GDSGVTGESTPAPESDSGSF-
TH_2241|M.thermoresistible__bu      --RTGDADAVPV---------
MAB_4145|M.abscessus_ATCC_1997      --ATGDSIAPEQPAVLGGEPL