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MAPSGGQEAQICDSETFGDSDFVVVANRLPVDLERLPDGSTTWKRSPGGLVTALEPVLRRRRGAWVGWPG VNDDGAEPDLHVLDGPIIQDELELHPVRLSTTDIAQYYEGFSNATLWPLYHDVIVKPLYHREWWDRYVDV NQRFAEAASRAAAHGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQMPWRTEIIQGLLG ADLVGFHLPGGAQNFLILSRRLVGTDTSRGTVGVRSRFGAAVLGSRTIRVGAFPISVDSGALDHAARDRN IRRRAREIRTELGNPRKILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVVVQLATPSRERVESYQT LRNDIERQVGHINGEYGEVGHPVVHYLHRPAPRDELIAFFVASDVMLVTPLRDGMNLVAKEYVACRSDLG GALVLSEFTGAAAELRHAYLVNPHDLEGVKDGIEEALNQTEEAGRRRMRSLRRQVLAHDVDRWAQSFLDA LAGAHPRGQG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3490 | otsA | - | 100% (500) | PROBABLE ALPHA, ALPHA-TREHALOSE-PHOSPHATE SYNTHASE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3520 | otsA | 0.0 | 99.80% (500) | alpha,alpha-trehalose-phosphate synthase |
| M. gilvum PYR-GCK | Mflv_1566 | - | 0.0 | 77.08% (493) | Alpha,alpha-trehalose-phosphate synthase (UDP-forming) |
| M. leprae Br4923 | MLBr_02254 | otsA | 0.0 | 80.28% (497) | putative trehalose-phosphate synthase |
| M. abscessus ATCC 19977 | MAB_4145 | - | 0.0 | 78.11% (475) | alpha,alpha-trehalose-phosphate synthase |
| M. marinum M | MMAR_4978 | otsA | 0.0 | 87.90% (496) | alpha, alpha-trehalose-phosphate synthase |
| M. avium 104 | MAV_0666 | otsA | 0.0 | 82.49% (497) | UDP-forming alpha,alpha-trehalose-phosphate synthase |
| M. smegmatis MC2 155 | MSMEG_5892 | - | 0.0 | 79.32% (498) | alpha,alpha-trehalose-phosphate synthase (UDP-forming) |
| M. thermoresistible (build 8) | TH_2241 | otsA | 0.0 | 79.88% (482) | PROBABLE ALPHA, ALPHA-TREHALOSE-PHOSPHATE SYNTHASE |
| M. ulcerans Agy99 | MUL_4052 | otsA | 0.0 | 87.70% (496) | alpha, alpha-trehalose-phosphate synthase |
| M. vanbaalenii PYR-1 | Mvan_5192 | - | 0.0 | 77.42% (496) | Alpha,alpha-trehalose-phosphate synthase (UDP-forming) |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3490|M.tuberculosis_H37Rv MAPSGGQEAQICDSET---FGDSDFVVVANRLPVDLERLPDGSTTWKRSP
Mb3520|M.bovis_AF2122/97 MAPSGGQEAQICDSET---FGDSDFVVVANRLPVDLERLPDGSTTWKRSP
MMAR_4978|M.marinum_M MGPGGRQSAEPASTEV---FGDSDFVVVANRLPVDQERLPDGTIAWKRSP
MUL_4052|M.ulcerans_Agy99 MGPGGRQSAEPASTEV---FGDSDFVVVANRLPVDQERLPDGTIAWKRSP
MAV_0666|M.avium_104 MAPGGGRGSKTAS------YGNSDFVVVANRLPVDQERLPDGSTAWKRSP
MLBr_02254|M.leprae_Br4923 MTSRGNHGSKTSSDKH---LGDSDFVVVANRLPVDQVRLPDGTAIWKRSP
Mflv_1566|M.gilvum_PYR-GCK MTDQSGNGVRSGSASEAPPSAKADFVVVANRLPIDQVNLPDGSTEWKRSP
Mvan_5192|M.vanbaalenii_PYR-1 MAPQSGPEARSG---------GADFVVVANRLPIDMVRRADGTTEFKRSP
MSMEG_5892|M.smegmatis_MC2_155 MSPESGHETISG---------TSDFVVVANRLPVDLERLPDGTTRWKRSP
TH_2241|M.thermoresistible__bu MADRGDSG-------------DSDFVVVANRLPIDLERAPDGTTSWKRSP
MAB_4145|M.abscessus_ATCC_1997 MATQSDERSPVKPVTG-----TSDFVVVANRLPIDLVKLPDGSTTWKRSP
* . :**********:* . .**: :****
Rv3490|M.tuberculosis_H37Rv GGLVTALEPVLRRRRGAWVGWPGVNDDGAEPDLHVLDGPIIQDELELHPV
Mb3520|M.bovis_AF2122/97 GGLVTALEPVLRRRRGAWVGWPGVNDDGAEPDLHVLDGPIIQDELELHPV
MMAR_4978|M.marinum_M GGLVTALEPLLRRRRGAWVGWAGVVEN----DVDVQDEPIVQDELQLQPV
MUL_4052|M.ulcerans_Agy99 GGLVTALEPLLRRRRGAWVGWAGVVEN----DVDVQDEPIVQDELQLQPV
MAV_0666|M.avium_104 GGLVTALEPLLRRQRGAWVGWPGIVDE----DVDHEDDPIVQDDLELRPV
MLBr_02254|M.leprae_Br4923 GGLVTALEPLLRQRRGAWVGWPGVINDN--VDLDLTIKSIVQDGLTLYPV
Mflv_1566|M.gilvum_PYR-GCK GGLVTALEPLLRRRHGAWIGWPGVPEDA--DDPDASTEPIEQDGMTLVPV
Mvan_5192|M.vanbaalenii_PYR-1 GGLVTALEPLLRRRHGAWIGWPGVPEDA--DDPNAATEPIEQDGMTLVPV
MSMEG_5892|M.smegmatis_MC2_155 GGLVTALEPLLRKRRGSWIGWAGVADSD--E------EPIVQDGLQLHPV
TH_2241|M.thermoresistible__bu GGLVTALEPLLRRRRGAWIGWPGIPDSD--------EDPIVDGDLVLYPV
MAB_4145|M.abscessus_ATCC_1997 GGLVTAMEPLLRKRRGAWVGWPGVPDAD--------VEPVSEDDMVLYSV
******:**:**:::*:*:**.*: : .: :. : * .*
Rv3490|M.tuberculosis_H37Rv RLSTTDIAQYYEGFSNATLWPLYHDVIVKPLYHREWWDRYVDVNQRFAEA
Mb3520|M.bovis_AF2122/97 RLSTTDIAQYYEGFSNATLWPLYHDVIVKPLYHREWWDRYVDVNQRFAEA
MMAR_4978|M.marinum_M RLSADDVAQYYEGFSNATLWPLYHDVIVRPIYHREWWDRYVDVNRRFAEA
MUL_4052|M.ulcerans_Agy99 RLSADDVAQYYEGFSNATLWPLYHDVIVRPIYHREWWDRYVDVNRRFAEA
MAV_0666|M.avium_104 KLSADDVAEYYEGFSNATLWPLYHDVIVKPIYHREWWDRYVAVNRRFAEA
MLBr_02254|M.leprae_Br4923 RLNTHDVAEYYEGFSNATLWPLYHDVIVKPIYHCEWWERYVDVNRRFAET
Mflv_1566|M.gilvum_PYR-GCK RLSAADVAKYYEGFSNATLWPLYHDVIVKPTYHREWWERYVEVNRRFAEA
Mvan_5192|M.vanbaalenii_PYR-1 RLSSEDVAEYYEGFSNATLWPLYHDVIVKPIYHREWWDRYVDVNRRFAEA
MSMEG_5892|M.smegmatis_MC2_155 RLSADDVAKYYEGFSNATLWPLYHDLIVKPEYHREWWDRYVEVNRRFAEA
TH_2241|M.thermoresistible__bu RLSADDVAQYYEGFSNATLWPLYHDVIVKPIYNRQWWERYVEVNRRFAEA
MAB_4145|M.abscessus_ATCC_1997 RLSTQEVAEYYEGFSNATLWPLYHDVIVKPEYHREWWQAYVDVNRKFAEA
:*.: ::*:****************:**:* *: :**: ** **::***:
Rv3490|M.tuberculosis_H37Rv ASRAAAHGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQ
Mb3520|M.bovis_AF2122/97 ASRAAAHGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQ
MMAR_4978|M.marinum_M TARAAARGGTVWVQDYQLQLVPKMLRAMRPDLTIGFFLHIPFPPVELFMQ
MUL_4052|M.ulcerans_Agy99 TARAAARGGTVWVQDYQLQLVPKMLRAMRPDLTIGFFLHIPFPPVELFMQ
MAV_0666|M.avium_104 TSRAAARGATVWVQDYQLQLVPAMLRELRPDLTIGFFLHIPFPPVELFMQ
MLBr_02254|M.leprae_Br4923 TSRTAAYGGTVWVQDYQLQLVPKMLRIMRPDLTIGFFLHIPFPPVELFMQ
Mflv_1566|M.gilvum_PYR-GCK AARTAAEGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFLQ
Mvan_5192|M.vanbaalenii_PYR-1 TAHTAAEGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQ
MSMEG_5892|M.smegmatis_MC2_155 TARAAAEGATVWIQDYQLQLVPKMLRMLRPDVTIGFFLHIPFPPVELFMQ
TH_2241|M.thermoresistible__bu TSRAAARGATVWVQDYQLQLVPKMLRELRPDLTIGFFLHIPFPPVELFMQ
MAB_4145|M.abscessus_ATCC_1997 TAAVAAEGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQ
:: .** *.***:********* *** :***:****************:*
Rv3490|M.tuberculosis_H37Rv MPWRTEIIQGLLGADLVGFHLPGGAQNFLILSRRLVGTDTSRGTVGVRSR
Mb3520|M.bovis_AF2122/97 MPWRTEIIQGLLGADLVGFHLPGGAQNFLILSRRLVGTDTSRGTVGVRSR
MMAR_4978|M.marinum_M LPWRTEIIQGLLGADLVGFHLPGGAQNFLILSRRLVGADTSRGTVGVRSR
MUL_4052|M.ulcerans_Agy99 LPWRTEIIQGLLGADLVGFHLPGGAQNFLILSRRLVGADTSRGTVGVRSR
MAV_0666|M.avium_104 LPWRTEIVKGLLGADLVGFHLTGGAQNFLFLSRRLIGANTSRGAVGVRSR
MLBr_02254|M.leprae_Br4923 IPWRTEIIEGLLGADLVGFHLTSGAQNFLFLSRHLLGANTSRGLVGVRSR
Mflv_1566|M.gilvum_PYR-GCK MPWRTEIIEGLLGADLVGFHLPGGAQNFLILARRLLGAVTSRGNVGVRSR
Mvan_5192|M.vanbaalenii_PYR-1 MPWRTEIIEGLLGADLVGFHLPGGAQNFLILARRLIGATTSRGNVGVRSR
MSMEG_5892|M.smegmatis_MC2_155 MPWRTEIVEGLLGADLVGFHLPGGAQNFLVLSRRLVGANTSRASIGVRSR
TH_2241|M.thermoresistible__bu LPWRTEITDGLLGADLVGFHLPGGAQNFLFLARRLVGANTSRASVGVRSK
MAB_4145|M.abscessus_ATCC_1997 MPWRTEIVDGLLGADLIGFHLAGGAQNFMYLARRLVGASTSRASIGVRSR
:****** .*******:****..*****: *:*:*:*: ***. :****:
Rv3490|M.tuberculosis_H37Rv FGAAVLGSRTIRVGAFPISVDSGALDHAARDRNIRRRAREIRTELGNPRK
Mb3520|M.bovis_AF2122/97 FGAAVLGSRTIRVGAFPISVDSGALDHAARDRNIRRRAREIRTELGNPRK
MMAR_4978|M.marinum_M FGEVILGSRTIRVGAFPISIDSGALDQTARDRNIRRRSREIRAELGNPRK
MUL_4052|M.ulcerans_Agy99 FGEVILGSRTIRVGAFPISIDSGALDQTARDRNIRRRSREIRAELGNPRK
MAV_0666|M.avium_104 YGEVELESRVVRVGAFPISIDSTALDQTARHRDIRRRAREIRAELGNPRK
MLBr_02254|M.leprae_Br4923 FGEVQLKSHTVQVGAFPISIDSKEIDQATRDRNVRRRAREIRAELGNPRK
Mflv_1566|M.gilvum_PYR-GCK FGEVQFGFRKVKVGAFPISIDSAELDQHARTRATRQRAKEIRAELGNPRK
Mvan_5192|M.vanbaalenii_PYR-1 FGEVQFGFRTVKVGAFPISIDSAELDQHARSRATRQRAKEIRAELGNPRK
MSMEG_5892|M.smegmatis_MC2_155 FGEVQVGFRTVKVGAFPISIDSAELDGKARNRAIRQRARQIRAELGNPRK
TH_2241|M.thermoresistible__bu FGEVQIGSRTVKVGAFPISIDSADLDRQARQRSIRQRARQIRAELGNPRR
MAB_4145|M.abscessus_ATCC_1997 FGEIRVGFRTVKVGAFPISIDSTQLDSVSRSRQIRQRAKEIRAELGGPRK
:* . : ::*******:** :* :* * *:*:::**:***.**:
Rv3490|M.tuberculosis_H37Rv ILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVVVQLATPSRERVES
Mb3520|M.bovis_AF2122/97 ILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVLVQLATPSRERVES
MMAR_4978|M.marinum_M ILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVLVQLATPSRERVES
MUL_4052|M.ulcerans_Agy99 ILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVLVQLATPSRERVES
MAV_0666|M.avium_104 VLLGVDRLDYTKGIDVRLKAFSELLAEGRAKRDDTVLVQLATPSRERVDS
MLBr_02254|M.leprae_Br4923 ILLGVDRLDYTKGIDVRLRAFAELLAEGRAKRDDTVLVQLATPSRERVES
Mflv_1566|M.gilvum_PYR-GCK VLLGVDRLDYTKGIDVRLRAFSELLEEGRIDPEDTVLVQLATPSRERVQS
Mvan_5192|M.vanbaalenii_PYR-1 ILLGVDRLDYTKGIDVRLRAFSELLEEGRIDPEDTVLVQLATPSRERVES
MSMEG_5892|M.smegmatis_MC2_155 IMLGVDRLDYTKGIDVRLRALSELLEEKRIKRDDTVLVQLATPSRERVES
TH_2241|M.thermoresistible__bu ILLGVDRLDYTKGIDVRLQAFAELLAEGRVNREDTVFVQLATPSRERVEA
MAB_4145|M.abscessus_ATCC_1997 ILLGVDRLDYTKGIDIRLHAYEELLAEGRASREDTVFVQLATPSRERVDS
::*************:**:* *** * * . :***.***********::
Rv3490|M.tuberculosis_H37Rv YQTLRNDIERQVGHINGEYGEVGHPVVHYLHRPAPRDELIAFFVASDVML
Mb3520|M.bovis_AF2122/97 YQTLRNDIERQVGHINGEYGEVGHPVVHYLHRPAPRDELIAFFVASDVML
MMAR_4978|M.marinum_M YQTLRNDIERQVGHINGEYAEVGHPVVHYLHRPVPRNELIAFFVASDVML
MUL_4052|M.ulcerans_Agy99 YQTLRNDIERQVGHINGEYAEVGHPVVHYLHRPVPRNELIAFFVASDVML
MAV_0666|M.avium_104 YQQLRNDIERQVGHINGEYGEVGHPVVHYLHRPVPRNELIAFFVAADVML
MLBr_02254|M.leprae_Br4923 YKILRNDIERQVGHINGEYGEVGHPVVHYLHRPIPRDELIAFYVASDVML
Mflv_1566|M.gilvum_PYR-GCK YIEMREDIERQVGHVNGEFGKVGHPVLHYLHRPIPREDLVAFFVAADVML
Mvan_5192|M.vanbaalenii_PYR-1 YVAMREDIERQVGHVNGEFGEVGHPVLHYLHRPIPREDLVAFFVAADVML
MSMEG_5892|M.smegmatis_MC2_155 YIAMREDIERQVGHINGEYGEVGHPIVHYLHRPIPRDELIAFFVAADVML
TH_2241|M.thermoresistible__bu YRLLRDDIERQVGHINGEYGEVGHPVVHYLHRPVPREELIAFFVAADVML
MAB_4145|M.abscessus_ATCC_1997 YKKMRGDVEQQVGHINGEFGEVGHPVVHYLHRPVPREDLIAFFVAADVML
* :* *:*:****:***:.:****::****** **::*:**:**:****
Rv3490|M.tuberculosis_H37Rv VTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLE
Mb3520|M.bovis_AF2122/97 VTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLE
MMAR_4978|M.marinum_M VTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLE
MUL_4052|M.ulcerans_Agy99 VTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLE
MAV_0666|M.avium_104 VTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRQAYLVNPHDLE
MLBr_02254|M.leprae_Br4923 VTPLRDGMNLVAKEYVACRNDLGGALVLSEFTGAAAELRQAYLVNPHDLE
Mflv_1566|M.gilvum_PYR-GCK VTPLRDGMNLVAKEYVACRHDLGGALVLSEFTGAAAELRQAYLTNPHHLE
Mvan_5192|M.vanbaalenii_PYR-1 VTPLRDGMNLVAKEYVACRHDLGGALVLSEFTGAAAELRQAYLTNPHHIE
MSMEG_5892|M.smegmatis_MC2_155 VTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRQAYLVNPHDLE
TH_2241|M.thermoresistible__bu VTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELGQAYLVNPHNLD
MAB_4145|M.abscessus_ATCC_1997 VTPLRDGMNLVAKEYVACRSDLGGSLVLSEFTGAAAELRQAYLVNPHDID
******************* ****:************* :***.***.::
Rv3490|M.tuberculosis_H37Rv GVKDGIEEALNQTEEAGRRRMRSLRRQVLAHDVDRWAQSFLDALAGA---
Mb3520|M.bovis_AF2122/97 GVKDGIEEALNQTEEAGRRRMRSLRRQVLAHDVDRWAQSFLDALAGA---
MMAR_4978|M.marinum_M GVKDGIEEALNQTEEAGRRRMRSMRRQVLAHDVDRWARSFLDALADS---
MUL_4052|M.ulcerans_Agy99 GVNDGIEEALNQTEEAGRRRMRSMRRQVLAHDVDRWARSFLDALADS---
MAV_0666|M.avium_104 GVKDTVEAALNQSVEEGRRRMRSLRRQVLAHDVDRWARSFLDALAES---
MLBr_02254|M.leprae_Br4923 GVKDTIEAALNQLAEEARRRMRSLRRQVLAHDVDRWARSFLDALAEA---
Mflv_1566|M.gilvum_PYR-GCK GVKDAIEAALNQSPEEGRRRMRALRRQVLAHDVDRWARSFLDALASR---
Mvan_5192|M.vanbaalenii_PYR-1 GVKDAIEAALTQAPEEGRRRMRAMRRQVLAHDVDRWARSFLDALASK---
MSMEG_5892|M.smegmatis_MC2_155 GVKDKIEAAVNQNPEEGKRRMRALRRQVLAHDVDRWARSFLDALAATGET
TH_2241|M.thermoresistible__bu HVKDTMVAALNQTPEEGRRRMRALRRQVLAHDVDLWARSFLDALAST---
MAB_4145|M.abscessus_ATCC_1997 GVKDGIESALNQTPEEGRRRMRALRRQVLAHDVDRWARAFLEALSTP---
*:* : *:.* * .:****::********** **::**:**:
Rv3490|M.tuberculosis_H37Rv --HPRGQG-------------
Mb3520|M.bovis_AF2122/97 --HPRGQG-------------
MMAR_4978|M.marinum_M --RPNDSADAAD---------
MUL_4052|M.ulcerans_Agy99 --RPNDSADAAD---------
MAV_0666|M.avium_104 --GPRDG--------------
MLBr_02254|M.leprae_Br4923 --PARDAT-------------
Mflv_1566|M.gilvum_PYR-GCK --EPINEESH-----------
Mvan_5192|M.vanbaalenii_PYR-1 --EPVEG--------------
MSMEG_5892|M.smegmatis_MC2_155 GDSGVTGESTPAPESDSGSF-
TH_2241|M.thermoresistible__bu --RTGDADAVPV---------
MAB_4145|M.abscessus_ATCC_1997 --ATGDSIAPEQPAVLGGEPL