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M. thermoresistible (build 8) TH_1590 ()

annotation: CONSERVED HYPOTHETICAL PROTEIN
coordinates: 3053168 - 3054082
length: 305

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1590-100% (305)CONSERVED HYPOTHETICAL PROTEIN
M. thermoresistible (build 8)TH_1244-6e-1631.33% (249) CONSERVED HYPOTHETICAL PROTEIN
M. thermoresistible (build 8)TH_1842-3e-1432.05% (156) ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE)

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1674-1e-10062.41% (290) hypothetical protein Mb1674
M. gilvum PYR-GCKMflv_3535-1e-10971.54% (260) putative adenylate/guanylate cyclase
M. tuberculosis H37RvRv1647-1e-10062.41% (290) hypothetical protein Rv1647
M. leprae Br4923MLBr_01399-4e-9260.85% (281) hypothetical protein MLBr_01399
M. abscessus ATCC 19977MAB_2330-4e-8558.78% (262) putative purine cyclase-like protein
M. marinum MMMAR_2454-4e-9968.34% (259) hypothetical protein MMAR_2454
M. avium 104MAV_3122-4e-9970.36% (253) adenylate and guanylate cyclase catalytic domain-containing
M. smegmatis MC2 155MSMEG_3780-1e-10075.21% (242) adenylate and guanylate cyclase catalytic domain-containing
M. ulcerans Agy99MUL_1633-3e-9968.34% (259) hypothetical protein MUL_1633
M. vanbaalenii PYR-1Mvan_3321-1e-10568.89% (270) putative adenylate/guanylate cyclase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3535|M.gilvum_PYR-GCK          -------------------------MPQSLSFRLVGVDEDPPGD----PG
Mvan_3321|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_1590|M.thermoresistible__bu      ---------------------------VELDGEVEPSDRRTRGP----DG
MSMEG_3780|M.smegmatis_MC2_155      --------------------------------------------------
Mb1674|M.bovis_AF2122/97            -------------------MPGSARTTYPCHVEVGPQDSESGAP---DET
Rv1647|M.tuberculosis_H37Rv         -------------------MAGSARTTYPCHVEVGPQDSESGAP---DET
MMAR_2454|M.marinum_M               -------------------MPGSATTTYPCEVEVGADNGDPGVP---DET
MUL_1633|M.ulcerans_Agy99           -------------------------------MEVGADNGDPGVP---DET
MLBr_01399|M.leprae_Br4923          -------------------MPPSAKSTYPGQVEGAPHDGTPSAPQEPDED
MAV_3122|M.avium_104                -------------------------------MELARRDLDPGEP---EES
MAB_2330|M.abscessus_ATCC_1997      MDVEPSGLDAEPDGEFDSGIRKRRRGRTRGPVRHDSAQVTDGIDTTADEV
                                                                                      

Mflv_3535|M.gilvum_PYR-GCK          G----GQFAGPRG---------WFRDINHHDGVIAFLRRTRRALPGDPDF
Mvan_3321|M.vanbaalenii_PYR-1       -----------MG---------WLMGVNHHDGVVAFLRRARRALPGDPDF
TH_1590|M.thermoresistible__bu      AGFRSGRARGPLA---------WLKSANQNEGLVALVKRARRRLPGDPEF
MSMEG_3780|M.smegmatis_MC2_155      --------------------------------MVAAVRRFRRALPGDPEF
Mb1674|M.bovis_AF2122/97            ATAMASPVPRQRS------ALRWLRTVNRSPGLVSFIHRARRLLPGDPEF
Rv1647|M.tuberculosis_H37Rv         ATAMASPVPRQRS------ALRWLRTVNRSPGLVSFIHRARRLLPGDPEF
MMAR_2454|M.marinum_M               AITLAATAPRRRS------PVEWLRSTNHSPGVVAFVRRARRLLPGDPEF
MUL_1633|M.ulcerans_Agy99           AITLAATAPRRRS------PVEWLRSTNHSPGVVAFVRRARRLLPGDPEF
MLBr_01399|M.leprae_Br4923          TVTVPAPALIRRSSVSMPNAAQWLHTTNRSPRLVAMVRRARRLLPGDPDF
MAV_3122|M.avium_104                AAAQSASRRTALSVHN---ATQWLHNRNHSPGAVALVRRARRLLPGDPDF
MAB_2330|M.abscessus_ATCC_1997      PSTESASRHFARASR---TAGSWFRKMDRDPAVVAALRRARRSLPGDPYF
                                                                     :: ::* ** ***** *

Mflv_3535|M.gilvum_PYR-GCK          GDPLSVSGVGGPRAAARAADRLL-ERDAATREVSLGALQVWQALTERVSG
Mvan_3321|M.vanbaalenii_PYR-1       GDPLSVSGVGGPSAAARAADRYL-ERNAVTREVSLGALQVWQALTERVSG
TH_1590|M.thermoresistible__bu      GDPLSVAGGDGPSVVARAAGRLL-ERDAATREVSLATLQVWQALTERISG
MSMEG_3780|M.smegmatis_MC2_155      GDPLSVAGDGGPRAAARVADRLL-ERDAASREVSLGALQVWQALTERVSG
Mb1674|M.bovis_AF2122/97            GDPLSTAGEGGPRAAARAADRLLRDRDAASREVGLSVLQVWQALTEAVSR
Rv1647|M.tuberculosis_H37Rv         GDPLSTAGEGGPRAAARAADRLLRDRDAASREVGLSVLQVWQALTEAVSR
MMAR_2454|M.marinum_M               GDPLSTAGDGGPRAAARAADRLLGDRDAASREVSLSVLQVWQAFTEAVSR
MUL_1633|M.ulcerans_Agy99           GDPLSTAGDGGPRAAARAADRLLGDRDAASREVSLSVLQVWQAFTEAVSR
MLBr_01399|M.leprae_Br4923          GDPLSTAGEGGPRAAARAADRLLGDRGAASREVSLSVLQVWQALTEAIAR
MAV_3122|M.avium_104                GDPLSTAGDGGPRAAARAADRLLGDRDAVSREVSLGVLQVWQALTEGISR
MAB_2330|M.abscessus_ATCC_1997      GDPLSTSGFGGASAVARAADRLVTDRDTAVREFGFGALQIWQAFTEKVSK
                                    *****.:* .*. ..**.*.* : :*.:. **..:..**:***:** :: 

Mflv_3535|M.gilvum_PYR-GCK          RPANPEVTLVFTDLVGFSAWSLRSGDDATLRLLRRVAQVVEPPLLQSGGH
Mvan_3321|M.vanbaalenii_PYR-1       RPANAEVTLVFTDLVGFSTWSLGAGDDATLRLLRRVAQVVEPPLLEAGGH
TH_1590|M.thermoresistible__bu      RPANPEVTLVFTDLVGFSSWALKAGDDATLRLLRRVAQVVEPPLLAAGGR
MSMEG_3780|M.smegmatis_MC2_155      RPANREVTLVFTDLVGFSSWSLRAGDDATLRLLRRVAQVAEPPLLEAGGH
Mb1674|M.bovis_AF2122/97            RPANPEVTLVFTDLVGFSTWSLHAGDDATLTLLRQVARAVESPLLDAGGH
Rv1647|M.tuberculosis_H37Rv         RPANPEVTLVFTDLVGFSTWSLHAGDDATLTLLRQVARAVESPLLDAGGH
MMAR_2454|M.marinum_M               RPANAEVTLVFTDLVGFSTWSLQAGDDAALKLLRQVARAVEPPLLDAGGH
MUL_1633|M.ulcerans_Agy99           RPANAEVTLVFTDLVGFSTWSLQAGDDAALKLLRQVARAVEPPLLDAGGH
MLBr_01399|M.leprae_Br4923          RPVNPEVTLVFTDLVGFSGWSLQAGDEATLALLRQVARAVESPLLDAGGH
MAV_3122|M.avium_104                RPANPEVTLVFTDLVGFSTWSLQAGDDAALALLRQVARAVEPPLLDAGGH
MAB_2330|M.abscessus_ATCC_1997      QPANREVTLVFTDLVGFSGWALEAGDEATLKLLRRVASVSEPPLLSAGGQ
                                    :*.* ************* *:* :**:*:* ***:** . *.*** :**:

Mflv_3535|M.gilvum_PYR-GCK          IVKRMGDGLMAVFADPTTAVRSAIAAREAVKTVDVDGYTPRMRVGIHTGR
Mvan_3321|M.vanbaalenii_PYR-1       IVKRMGDGLMAVFTDATTAVRAAIEARDAVKSLDVDGYTPRMRVGIHTGR
TH_1590|M.thermoresistible__bu      IVKRMGDGSMVVFTEPVPAVRAALAAKDAVKSVEVDGYTPRMRVGVHTGR
MSMEG_3780|M.smegmatis_MC2_155      IVKRMGDGMMAVFGDPATAVRAVLVALDAVKGIEVDGYTPRMRVGIHTGR
Mb1674|M.bovis_AF2122/97            IVKRLGDGIMAVFRNPTVALRAVLVAQDAVKSLEVQGYTPRMRIGIHTGR
Rv1647|M.tuberculosis_H37Rv         IVKRLGDGIMAVFRNPTVALRAVLVAQDAVKSLEVQGYTPRMRIGIHTGR
MMAR_2454|M.marinum_M               IVKRLGDGIMAVFRNPTVAVRAVLIAQDAVKAVEVEGYTPRMRVGIHTGR
MUL_1633|M.ulcerans_Agy99           IVKRLGDGIMAVFRNPTVAVRAVLIAQDAVKAVEVEGYTPRMRVGIHTGR
MLBr_01399|M.leprae_Br4923          IVKRMGDGIMAVFRDPSVAVQAVLAATEAMKSVEVGGYTPRIRVGIHTGR
MAV_3122|M.avium_104                IVKRMGDGLMAVFGDPTVAVRAVLAAKEALRSVEVAGYTPRMRVGIHTGR
MAB_2330|M.abscessus_ATCC_1997      VVKRMGDGIMAVFDDPVTALRAIIPARDALKNVEIQGYTPVMRIGIHAGT
                                    :***:*** *.** :.  *::: : * :*:: ::: **** :*:*:*:* 

Mflv_3535|M.gilvum_PYR-GCK          PQRIGSDWLGIDVNLAARVMERATRGELVISEATLQRIPDEDFDVLPVTA
Mvan_3321|M.vanbaalenii_PYR-1       PQRIGSDWLGIDVNLAARVMERATRGELVVSGATLERIPDDEFQTLGVTA
TH_1590|M.thermoresistible__bu      PQHIGSDWLGVDVNIAARVMERATRGGVMVSQTTLDRISDEDFDALNVTA
MSMEG_3780|M.smegmatis_MC2_155      PQRIGSDWLGVDVNITARVMERAAKGGLMVSHATLAGIADGELAELGVTV
Mb1674|M.bovis_AF2122/97            PQRLAADWLGVDVNIAARVMERATKGGIMISQPTLDLIPQSELDALGVVA
Rv1647|M.tuberculosis_H37Rv         PQRLAADWLGVDVNIAARVMERATKGGIMISQPTLDLIPQSELDALGVVA
MMAR_2454|M.marinum_M               PQRLAADWLGVDVNIAARVMERATKGGVMISSPTLDLIPQSELDAMRVVA
MUL_1633|M.ulcerans_Agy99           PQRLAADWLGVDVNIAARVMERATKGGVMISSPTLDLIPQSELDAMRVVA
MLBr_01399|M.leprae_Br4923          PQRLAADWLGVDVNIAARVMERATKGGIMISGPTLDLIPQSDLKELGIIT
MAV_3122|M.avium_104                PQRLASDWLGVDVNIAARVMERATKGGIMVSSSTLDHIPQSELDALGVEA
MAB_2330|M.abscessus_ATCC_1997      PQRIGSDWLGVDVNIAARVMESAAKGGLAISQPALAKVPLAFLDHMGLTP
                                    **::.:****:***::***** *::* : :* .:*  :.   :  : :  

Mflv_3535|M.gilvum_PYR-GCK          KKLRRQVFAARADGVPDDFTMYRLRTRRPVRGHEDDHDEVPGEE--
Mvan_3321|M.vanbaalenii_PYR-1       KKLRRPVFAGKQDGVPGDFAMYRLRTHRQSPGAEEG--VVAGG---
TH_1590|M.thermoresistible__bu      KRVRRSLFAPQPDGVPEGLTVYRLRAAAGGTGPSGG-PAESGEKPR
MSMEG_3780|M.smegmatis_MC2_155      KRERRQLFSARPDGVPEDLVMYRVRTPSRLPAARPREQEPPDA---
Mb1674|M.bovis_AF2122/97            RRVRKPVFASKPTGIPPDLAIYRIKTVSESTAADNFDEMSPDAQ--
Rv1647|M.tuberculosis_H37Rv         RRVRKPVFASKPTGIPPDLAIYRIKTVSESTAADNFDEMSPDAQ--
MMAR_2454|M.marinum_M               KRARRPMFASKLTGIPPDLAIYRLTTRKDLATIGDTADTDLQA---
MUL_1633|M.ulcerans_Agy99           KRARRPMFASKLTGIPPDLAIYRLTTRKDLATIGDTADTDLQA---
MLBr_01399|M.leprae_Br4923          RRVRKPMFTSKFTGIPPDMVIYRIKARRELTASDETAQTNSLT---
MAV_3122|M.avium_104                KRTRKPVFGPKPAGMPADLAIYRLKTLKELSASDDTDETKPQP---
MAB_2330|M.abscessus_ATCC_1997      TPVRRPLFSSRPAGVPENMKMYLLETRRQLPAPGDDGRV-------
                                       *: :*  :  *:* .: :* : :