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M. thermoresistible (build 8) TH_1380 (-)

annotation: ATPase, AAA family protein
coordinates: 2612411 - 2614006
length: 532

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1380--100% (532)ATPase, AAA family protein
M. thermoresistible (build 8)TH_3592-1e-8942.18% (486) PUTATIVE AAA ATPase, central domain protein
M. thermoresistible (build 8)TH_2647-8e-0529.45% (146) PUTATIVE chaperone ClpB

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0290-0.073.93% (537) hypothetical protein Mb0290
M. gilvum PYR-GCKMflv_0329-0.078.34% (531) ATPase central domain-containing protein
M. tuberculosis H37RvRv0282-0.073.93% (537) hypothetical protein Rv0282
M. leprae Br4923MLBr_02537-0.074.07% (536) hypothetical protein MLBr_02537
M. abscessus ATCC 19977MAB_2234c-0.069.70% (528) hypothetical protein MAB_2234c
M. marinum MMMAR_0541-0.073.74% (537) hypothetical protein MMAR_0541
M. avium 104MAV_4871-0.076.40% (534) ATPase, AAA family protein
M. smegmatis MC2 155MSMEG_0615-0.079.66% (531) ATPase, AAA family protein
M. ulcerans Agy99MUL_1204-0.073.74% (537) hypothetical protein MUL_1204
M. vanbaalenii PYR-1Mvan_0411-0.078.49% (530) ATPase central domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb0290|M.bovis_AF2122/97            --------MAGVGAGDSGGVERDDIGMVAASPVASRVNGKVDADVVGRFA
Rv0282|M.tuberculosis_H37Rv         --------MAGVGEGDSGGVERDDIGMVAASPVASRVNGKVDADVVGRFA
MMAR_0541|M.marinum_M               -------------------MKRGDIGMPAAQSPTSRVSGRVDADVVSRFA
MUL_1204|M.ulcerans_Agy99           -------------------MKRGDIGMPAAQSPTSRVSGRVDADVVSRFA
MAV_4871|M.avium_104                -------------------MERGDTGMLTAQPVNSRVDARVDGDVVSRFA
MLBr_02537|M.leprae_Br4923          MLISGRSGWAILGTGGKAAVNRGDAGKLGGQSVIARAHVKVDGDVVSRFA
Mflv_0329|M.gilvum_PYR-GCK          ------------------------MDIGSDTLAPPAGTSRVDQDVVSRFA
Mvan_0411|M.vanbaalenii_PYR-1       ------------------------MDIGSDTLAAAAGTVRVDQHVVSRFA
MSMEG_0615|M.smegmatis_MC2_155      --------------------------------------------MVSRFA
TH_1380|M.thermoresistible__bu      --------------------------------------------------
MAB_2234c|M.abscessus_ATCC_199      ------------------MDIRERVGQRGWAAQDVASATRIDPELESRFA
                                                                                      

Mb0290|M.bovis_AF2122/97            TCCRALGIAVYQRKRPPDLAAARSGFAALTRVAHDQCDAWTGLAAAGDQS
Rv0282|M.tuberculosis_H37Rv         TCCRALGIAVYQRKRPPDLAAARSGFAALTRVAHDQCDAWTGLAAAGDQS
MMAR_0541|M.marinum_M               TCCRALGIAVYDRKRPADLDAARSGFGALTRVASDQCDAWTGLAAAGDQS
MUL_1204|M.ulcerans_Agy99           TCCRALGIAVYDRKRPADLDAARSGFGALTRVASDQCDAWTGLAAAGDQS
MAV_4871|M.avium_104                TCCRALGIVVYQRQRPADLAAARSGFAALTRIAHDQCDAWTGLAAAGDVS
MLBr_02537|M.leprae_Br4923          TCCRALGLAVYDRQRPADLAAARSGFTALARIAHDQCDVWIGLAAAGDVS
Mflv_0329|M.gilvum_PYR-GCK          TCCRALGLSVHERRRPADLTAARAGFAALTRIASDQCDAWTGLAAAGDVT
Mvan_0411|M.vanbaalenii_PYR-1       TCCRALGLVVHDRRRPADLAAARSGFAALTRIAHDQCDAWVGLAAAGDDA
MSMEG_0615|M.smegmatis_MC2_155      TCCRALGLTVNDRQRPADLTAARAGFAGLTHLAHDQCDAWIGLAAAGEVT
TH_1380|M.thermoresistible__bu      --------------------------------------------------
MAB_2234c|M.abscessus_ATCC_199      TCCRALGLSVNDRRRPADLPAARYGFTSLCRTAQDQCDVWVGLAAAGGAT
                                                                                      

Mb0290|M.bovis_AF2122/97            IGVLEAASRTA-TTAGVLQRQVELADNALGFLYDTGLYLRFRATGPDDFH
Rv0282|M.tuberculosis_H37Rv         IGVLEAASRTA-TTAGVLQRQVELADNALGFLYDTGLYLRFRATGPDDFH
MMAR_0541|M.marinum_M               IGVLEAVSRTA-GTAGTLQRHVELAAGSLGFLYDTGLYLRFRATDPDGFH
MUL_1204|M.ulcerans_Agy99           IGVLEAVLRTA-GTAGTLQRHVELAAGSLGFLYDTGLYLRFRATDPDGFH
MAV_4871|M.avium_104                LRVLEAVARTA-ATAGVLQRQVDLAPGALGFRYDTGLYLQFRATTTDDFQ
MLBr_02537|M.leprae_Br4923          TPVLAAISCTA-DTAGMLQRQVELAPAALGFHYDTGLYLQFRAIGPDDFH
Mflv_0329|M.gilvum_PYR-GCK          PQVIERVWQTSGATAGLLSRRIELAPQALGFTYDSGLYLRFRASTPDDFA
Mvan_0411|M.vanbaalenii_PYR-1       PHVVEAVWRTS-ATFGVLQREIQLAPGALGFRYDTGLYLRFRATTRDDFA
MSMEG_0615|M.smegmatis_MC2_155      PAVVDAVWRTV-ASAGVLQREIGLAAGELGFTYDTGWYLQFRATEPDDFQ
TH_1380|M.thermoresistible__bu      --VLEAVWRTV-DTAGVLQDEVELAPGALGFHYDTGLYLQFRATDRDDFQ
MAB_2234c|M.abscessus_ATCC_199      VDVLEAISETT-ATAGHLQHAVNLHPGDLTFTYDTGLYLEFRAGGPDDYH
                                      *:     *   : * *.  : *    * * **:* **.***   *.: 

Mb0290|M.bovis_AF2122/97            LAYAAALASTGGPEEFAKANHVVSGITERRAGWRAARWLAVVINYRAERW
Rv0282|M.tuberculosis_H37Rv         LAYAAALASTGGPEEFAKANHVVSGITERRAGWRAARWLAVVINYRAERW
MMAR_0541|M.marinum_M               LAYAAALALAGESAQFAKANELVSGIVDRRPSWRDARWLAVVINYRAQRW
MUL_1204|M.ulcerans_Agy99           LAYAAALALAGESAQFAKANELVSGIVDRRPSWRDARWLAVVINYRAQRW
MAV_4871|M.avium_104                LAYAAALATAG---RFADADRIVAALTAARPGWREARWVSVVINYRAERW
MLBr_02537|M.leprae_Br4923          LAYAASLASTGGPGPYAEADQIVTGIIDRRPGWRDARWVAAVIHYRAGRW
Mflv_0329|M.gilvum_PYR-GCK          LAYTVCLSDAA---CYEEADQLLEGLLARRRGWFEARWVRIAMYHRAARW
Mvan_0411|M.vanbaalenii_PYR-1       LAYAVRLCDTD---AYEEADELIAGLLERRPQWLEARWVRAVLHYRTARW
MSMEG_0615|M.smegmatis_MC2_155      LAYAARLYEAG---EFGEADGLVGEILARRPGWFDARWLQVAINHRAQRW
TH_1380|M.thermoresistible__bu      LAYATTLADAG---RYVDADRLVAELADRRPDWRQARWVRVALHHRAERW
MAB_2234c|M.abscessus_ATCC_199      LAYAAALVDKG---EYDKANELIAAVTARRPGWFNARWVAVAMQNRAQRW
                                    ***:. *        : .*: ::  :   *  *  ***:  .:  *: **

Mb0290|M.bovis_AF2122/97            SDVVKLLTPMVNDPDLDEAFSHAAKITLGTALARLGMFAPALSYLEEPDG
Rv0282|M.tuberculosis_H37Rv         SDVVKLLTPMVNDPDLDEAFSHAAKITLGTALARLGMFAPALSYLEEPDG
MMAR_0541|M.marinum_M               SDVVKLLTPIVNDSELDEAFAHAAKITLGTALARLGMFAPALSYLEEPDG
MUL_1204|M.ulcerans_Agy99           SDVVKLLTPIVNDSELDEAFAHAAKITLGTALARLGMFAPALSYLEEPDG
MAV_4871|M.avium_104                SDVVKLLTPIVNDTDLDDAYAHAAKIALGTALARLGMFAPALSYLEEPDG
MLBr_02537|M.leprae_Br4923          SDVVKLLTPIVNDPDIDEAYTHAAKIALGTALARLGMFAPALSYLEEPAG
Mflv_0329|M.gilvum_PYR-GCK          SDVVRMLTPLVTDATLDETSAHAARVTLGIALARLGMFAPALSYLERPEG
Mvan_0411|M.vanbaalenii_PYR-1       NDVVRMLTPLVADQSLEETPAHAARVALGTALARLGMFAPALSHLERPEG
MSMEG_0615|M.smegmatis_MC2_155      SDVVRLLTPVVTLPSLDDVTSHAVRTALGISLARLGMFAPAMSYLEDPAG
TH_1380|M.thermoresistible__bu      SDVVRLLTPVVNDPGLDELYSHAARVTLGIALARLGMFAPALSYLEEPDG
MAB_2234c|M.abscessus_ATCC_199      ADVVSLLTPVVTDESLDPTTSHAVRITLGIALAKLGMVNPALSYLEDPSG
                                     *** :***:*    ::   :**.: :** :**:***. **:*:** * *

Mb0290|M.bovis_AF2122/97            PVAVAAVDGALAKALVLRAHVDEESASEVLQDLYAAHPENEQVEQALSDT
Rv0282|M.tuberculosis_H37Rv         PVAVAAVDGALAKALVLRAHVDEESASEVLQDLYAAHPENEQVEQALSDT
MMAR_0541|M.marinum_M               PVPVAAVDGALAKALVLRAHVDEESASEVLQDLYAAHPENEQIEHALSDT
MUL_1204|M.ulcerans_Agy99           PVPVAAVDGALAKALVLRAHVDEESASEVLQDLYAAHPENEQIEHALSDT
MAV_4871|M.avium_104                PVAVAAVDGALAKALVLRAHVDEESASEVLQDLYAAHPENEQVEQALSDT
MLBr_02537|M.leprae_Br4923          PVAVAAVDGALAKALVLRAHTDEESASEVLQDLYAAHPDNEQIEQALSDT
Mflv_0329|M.gilvum_PYR-GCK          PVTVAATDGALVKALSLRAQGEDEEALQLLQELYAVNPEHAQIEEALLDT
Mvan_0411|M.vanbaalenii_PYR-1       PVVVASVDGALVKALSLRAQGEDEEAHELLQELYAANPENVQIEEALSDS
MSMEG_0615|M.smegmatis_MC2_155      PIEVAAVDGALAKALTLRAQGEDDEATEVLQDLFATHPENTQVEQALLDT
TH_1380|M.thermoresistible__bu      PVAVAALDGTFAKALTLRAQGEEDEAAEVLQDLYAAHPENAEIEEALLDT
MAB_2234c|M.abscessus_ATCC_199      PIEVAATDGALAKALNLRHHGDEETATEVLQDLYAANPENAEIEHALTDP
                                    *: **: **::.*** ** : ::: * ::**:*:*.:*:: ::*.** *.

Mb0290|M.bovis_AF2122/97            SFGIVTTTAGRIEARTDPWDPATEPGAEDFVDPAAHERKAALLHEAELQL
Rv0282|M.tuberculosis_H37Rv         SFGIVTTTAGRIEARTDPWDPATEPGAEDFVDPAAHERKAALLHEAELQL
MMAR_0541|M.marinum_M               SFGIVTTTTGQIEARTDPWDPETEPSADDFVDPSAHERKGVLLHEAELQL
MUL_1204|M.ulcerans_Agy99           SFGIVTTTTGQIEARTDPWDPETEPSADDFVDPSAHERKGVLLHEAELQL
MAV_4871|M.avium_104                SFGIVTTTAARIEARTDPWDPATEPSAEDFVDPAAHERKAVLLAEAERQL
MLBr_02537|M.leprae_Br4923          SFGIVTTTAARIDARTDPWDPETEPGVEDFIDPAAHERKAVLLHEAERQL
Mflv_0329|M.gilvum_PYR-GCK          SFGIPTTTAARIEARSNPWDPETEPGEADFVDSGAKDRKAHLLVEAEAEL
Mvan_0411|M.vanbaalenii_PYR-1       SFGIPTTTAARIEARSNPWDPGTEPGEADFVDPGAKDRKAHLLIEAEAEL
MSMEG_0615|M.smegmatis_MC2_155      SFGLVTTTSARIEARSDPWDPETEPSEAEFVDPGAKDRKAHLLLEAEAEL
TH_1380|M.thermoresistible__bu      TYGLPTTTAARIEARSNPWDPDSEPTEEEFVDPGAKERKAHLLVEAEAEL
MAB_2234c|M.abscessus_ATCC_199      SVGLHTTTSARIAARTDPWDPETEPSEEDFIDPEAHERKAILLAEAEQQL
                                    : *: ***:.:* **::**** :**   :*:*. *::**. ** *** :*

Mb0290|M.bovis_AF2122/97            AEFIGLDEVKRQVSRLKSSVAMELVRKQRGLTVAQRTHHLVFAGPPGTGK
Rv0282|M.tuberculosis_H37Rv         AEFIGLDEVKRQVSRLKSSVAMELVRKQRGLTVAQRTHHLVFAGPPGTGK
MMAR_0541|M.marinum_M               AEFIGLEEVKNQVSRLKSSVAMELVRKQRGLAVAQRTHHLIFAGPPGTGK
MUL_1204|M.ulcerans_Agy99           AEFIGLEEVKNQVSRLKSSVAMELVRKQRGLAVAQRTHHLIFAGPPGTGK
MAV_4871|M.avium_104                AEFIGLDEVKNQVSRLKSSVAMELVRKQRGLAVAQRAHHLVFAGPPGTGK
MLBr_02537|M.leprae_Br4923          AEFIGLDEVKNQVSRLKSSVAMELVRKQRGLMVAQRAHHLVFAGPPGTGK
Mflv_0329|M.gilvum_PYR-GCK          AEFIGLDEVKYQVARLKSSVAMAIRRQERGLAVAQRTNHLVFAGPPGTGK
Mvan_0411|M.vanbaalenii_PYR-1       AEFIGLDEVKYQVARLKSSVAMAIRRQERGLTVAQRTNHLVFAGPPGTGK
MSMEG_0615|M.smegmatis_MC2_155      AEFIGLEEVKFQVARLKSSVAMAIRRQERGLAVAQRTNHLVFAGPPGTGK
TH_1380|M.thermoresistible__bu      AEFIGLEEVKYQVARLKSSVAMAIKRQERGLTVAQRTNHLVFAGPPGTGK
MAB_2234c|M.abscessus_ATCC_199      SEFIGLEQVKDQVARLKSSVAMALRRQDRGLAVGHRTHHLVFAGPPGTGK
                                    :*****::** **:******** : *::*** *.:*::**:*********

Mb0290|M.bovis_AF2122/97            TTIARVVAKIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSAL
Rv0282|M.tuberculosis_H37Rv         TTIARVVAKIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSAL
MMAR_0541|M.marinum_M               TTIARVVAKIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSAL
MUL_1204|M.ulcerans_Agy99           TTIARVVAKIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSAL
MAV_4871|M.avium_104                TTIARVVAKIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSAL
MLBr_02537|M.leprae_Br4923          TTIARVVAKVYCGLGLLKKENIREVHRADLIGQHIGETEAKTNAVIDSAL
Mflv_0329|M.gilvum_PYR-GCK          TTIARVVAKIYCGLGLLKKETVREVHRADLIGQHIGETEAKTNAIIDSAL
Mvan_0411|M.vanbaalenii_PYR-1       TTIARVVAKIYCGLGLLKKETVREVHRADLIGQHIGETEAKTNAIIDSAL
MSMEG_0615|M.smegmatis_MC2_155      TTIARVVAKIYCGLGLLKKETVREVHRADLIGQHIGETEAKTNAIIDSAL
TH_1380|M.thermoresistible__bu      TTIARVVAKIYCGLGILKKETVREVHRADLVGQHIGETEAKTNAVIDSAL
MAB_2234c|M.abscessus_ATCC_199      TTIARVVAKIYCGLGLLKRENVREVHRADLIGQHIGETEAKTNAVIDSAL
                                    *********:*****:**:*.:********:*************:*****

Mb0290|M.bovis_AF2122/97            DGVLFLDEAYALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRAD
Rv0282|M.tuberculosis_H37Rv         DGVLFLDEAYALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRAD
MMAR_0541|M.marinum_M               DGVLFLDEAYALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRAD
MUL_1204|M.ulcerans_Agy99           DGVLFLDEAYALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRAD
MAV_4871|M.avium_104                DGVLFLDEAYALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRAD
MLBr_02537|M.leprae_Br4923          DGVLFLDEAYALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRAD
Mflv_0329|M.gilvum_PYR-GCK          DGVLFLDEAYALVSTGAKNDFGLVAIDTLLARMENDRDRLVVIVAGYRKD
Mvan_0411|M.vanbaalenii_PYR-1       DGVLFLDEAYALVSTGAKNDFGLVAIDTLLARMENDRDRLVVIVAGYRKD
MSMEG_0615|M.smegmatis_MC2_155      DGVLFLDEAYALVSTGAKNDFGLVAIDTLLARMENDRDRLVVIVAGYRKD
TH_1380|M.thermoresistible__bu      DGVLFLDEAYALVSTGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRAD
MAB_2234c|M.abscessus_ATCC_199      DGVLFLDEAYALVSTGAKNDFGLVAIDTLLARMENDRDRLVVIVAGYRAE
                                    *************:*****************************:**** :

Mb0290|M.bovis_AF2122/97            LDKFLDTNEGLRSRFTRNIDFPSYTSHELVEIAHKMAEQRDSVFEQSALH
Rv0282|M.tuberculosis_H37Rv         LDKFLDTNEGLRSRFTRNIDFPSYTSHELVEIAHKMAEQRDSVFEQSALH
MMAR_0541|M.marinum_M               LDKFLDTNEGLRSRFTRSIDFPSYTSHELVEIAHKMAEQRDSIFEPAALQ
MUL_1204|M.ulcerans_Agy99           LDKFLDTNEGLRSRFTRSIDFPSYTSHELVEIAHKMAEQRDSIFEPAALQ
MAV_4871|M.avium_104                LDKFLDTNEGLRSRFTRNIDFPSYAPSELVEIATKMAEQRDSVFEQAALD
MLBr_02537|M.leprae_Br4923          LDKFLDTNEGLRSRFTRNIDFPSYASHELVEIAHKMAEQRDSVFEQAALD
Mflv_0329|M.gilvum_PYR-GCK          LDTFLDANEGLRSRFTRSIDFPSYSPKELVEIAVRMAEKRDSHFEDSARS
Mvan_0411|M.vanbaalenii_PYR-1       LDTFLDTNEGLRSRFTRSIDFPSYSGKELVEIATRMAEKRDSRFEDAARR
MSMEG_0615|M.smegmatis_MC2_155      LDAFLDTNEGLRSRFTRSIDFPSYTAPELVEIAVRMAEKRDSVFEKAAHD
TH_1380|M.thermoresistible__bu      LDKFLDTNEGLRSRFTRSIDFPSYSPHELVEMAKLMAAKRDSVFEPAALT
MAB_2234c|M.abscessus_ATCC_199      LDQFLDTNEGLRSRFTRSINFPSYAPSELVEIAAAMASVRDSKFDEGAEA
                                    ** ***:**********.*:****:  ****:*  **  *** *: .*  

Mb0290|M.bovis_AF2122/97            DLEALFAKLAAESTPDTNGISRRSLDIAGNGRFVRNIVERSEEEREFRLD
Rv0282|M.tuberculosis_H37Rv         DLEALFAKLAAESTPDTNGISRRSLDIAGNGRFVRNIVERSEEEREFRLD
MMAR_0541|M.marinum_M               DLEGLFARLAAGSTPDSNGVSRRSLDIAGNGRFVRNIVERSEEEREFRLD
MUL_1204|M.ulcerans_Agy99           DLEGLFARLAAGSTPDSNGVSRRSLDIAGNGRFVRNIVERSEEEREFRLD
MAV_4871|M.avium_104                HMEELFTKLARESTPDANGISRRNLDIAGNGRFVRNIVERAEEEREFRLD
MLBr_02537|M.leprae_Br4923          ELEVLFANLATSSTPDSNGISRRSLDIAGNGRFVRNIVERSEEEREFRLD
Mflv_0329|M.gilvum_PYR-GCK          DMESLFSYLAESSSPDANGVNRRSLDIAGNGRFVRNLVERSEEEREYRLD
Mvan_0411|M.vanbaalenii_PYR-1       DMERLFEYLAQATTPDVNGVSRRSLDIAGNGRFVRNLVERSEEEREYRLD
MSMEG_0615|M.smegmatis_MC2_155      DMERLFTHLAQATTPDANGVERRSLDIAGNARFVRNLVERSEEEREYRLD
TH_1380|M.thermoresistible__bu      EMERLFGHLAESSTADAQGVQRRSLDVAGNGRFVRNLVERSEEEREYRLD
MAB_2234c|M.abscessus_ATCC_199      ELLTAFSAMCAAEAPDTRGIARRSIDVAGNGRFVRNVVERSEEEREHRLD
                                    .:   *  :.   :.* .*: **.:*:***.*****:***:*****.***

Mb0290|M.bovis_AF2122/97            HSEHAGSGEFSDEELMTITADDVGRSVEPLLRGLGLSVRA------
Rv0282|M.tuberculosis_H37Rv         HSEHAGSGEFSDEELMTITADDVGRSVEPLLRGLGLSVRA------
MMAR_0541|M.marinum_M               HSEHAGSGEFSDDELMTITGSDVGRSVEPLLRGLGLSVPA------
MUL_1204|M.ulcerans_Agy99           HSEHAGSGEFSDDELMTITGSDVGRSVEPLLRGLGLSVPA------
MAV_4871|M.avium_104                HSEHAGTGEFTDEELMTITDDDVARSVEPLLRGLGLSVPA------
MLBr_02537|M.leprae_Br4923          HSNNVGTGELSDEELMTVTSEDVRRSVEPLLRGLGLMVPHD-----
Mflv_0329|M.gilvum_PYR-GCK          HSDAE---DFTDDELMTITAADVGQSAGPLLRGLGLAVPQHASDER
Mvan_0411|M.vanbaalenii_PYR-1       HSESD---DFTDDELMTITATDVANSAGPLLRGLGLSMPQQLSDQA
MSMEG_0615|M.smegmatis_MC2_155      HSDQE---DFTDEEMMTITAGDVQRSAAPLLRGLGLSVPA------
TH_1380|M.thermoresistible__bu      HADIE---DFTDEELMTITLEDVNNSAAPLLRGLGLTVPA------
MAB_2234c|M.abscessus_ATCC_199      NSGAE---EFSDDDLMTVTVEDVRASVEAIVAGLGLSASGASVKK-
                                    ::      :::*:::**:*  **  *. .:: ****