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M. thermoresistible (build 8) TH_1284 (pepR)

annotation: PROBABLE ZINC PROTEASE PEPR
coordinates: 2443275 - 2444549
length: 425

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1284pepR-100% (425)PROBABLE ZINC PROTEASE PEPR

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2805cpepR0.079.20% (423) zinc protease PEPR
M. gilvum PYR-GCKMflv_4022-0.081.13% (424) peptidase M16 domain-containing protein
M. tuberculosis H37RvRv2782cpepR0.079.20% (423) zinc protease PEPR
M. leprae Br4923MLBr_00855pepR0.075.66% (419) putative zinc protease
M. abscessus ATCC 19977MAB_3105c-1e-17173.45% (403) hypothetical protein MAB_3105c
M. marinum MMMAR_1926pepR0.079.38% (422) zinc protease PepR
M. avium 104MAV_3675-0.080.09% (422) protease
M. smegmatis MC2 155MSMEG_2657-0.083.92% (423) peptidase, M16 family protein
M. ulcerans Agy99-----
M. vanbaalenii PYR-1Mvan_2351-0.082.94% (422) peptidase M16 domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


TH_1284|M.thermoresistible__bu      ---------------------------------VRRTVLPGGLRVVTEYL
MSMEG_2657|M.smegmatis_MC2_155      -----------------------MTETRLETSQVRRTTLPGGLRVVTEYL
Mflv_4022|M.gilvum_PYR-GCK          ---------------------------------MRRTRLPGGLRVVTEHI
Mvan_2351|M.vanbaalenii_PYR-1       MQRRQAAS------SQALRRGKRGGDAPDKSTAVRRTQLPGGLRVVTEHI
Mb2805c|M.bovis_AF2122/97           MPRRSP-------------------ADPAAALAPRRTTLPGGLRVVTEFL
Rv2782c|M.tuberculosis_H37Rv        MPRRSP-------------------ADPAAALAPRRTTLPGGLRVVTEFL
MMAR_1926|M.marinum_M               MPPRQA-------------------ADPAAVPALRRTTLPGGLRVVTEYL
MLBr_00855|M.leprae_Br4923          ---------------------------------MCRTTLPGGLRVVTEHL
MAV_3675|M.avium_104                MPPADSRRRAADSSTGALRAGKVVEAQPHPHAALRRSTLPGGLRVVTEYL
MAB_3105c|M.abscessus_ATCC_199      -------------------------------------------------M
                                                                                     :

TH_1284|M.thermoresistible__bu      PSVHSVSVGVWVGVGSRDEGPSVAGAAHFLEHLLFKSTPTRSAVDIAQAV
MSMEG_2657|M.smegmatis_MC2_155      PYVRSASVGVWVGVGSRDEGRSVAGAAHFLEHLLFKSTPTRTAVDIAQTV
Mflv_4022|M.gilvum_PYR-GCK          PSVHSASVGVWVNVGSRDEGRSVAGAAHFLEHLLFKATPTRTAVQIAQAV
Mvan_2351|M.vanbaalenii_PYR-1       PSVHSASVGVWVNVGSRDEGRSVAGAAHFLEHLLFKATPTRTAVQIAQAV
Mb2805c|M.bovis_AF2122/97           PAVHSASVGVWVGVGSRDEGATVAGAAHFLEHLLFKSTPTRSAVDIAQAM
Rv2782c|M.tuberculosis_H37Rv        PAVHSASVGVWVGVGSRDEGATVAGAAHFLEHLLFKSTPTRSAVDIAQAM
MMAR_1926|M.marinum_M               PAVRSASVGVWVGVGSRDEGTTVAGAAHFLEHLLFKSTPTRTAVDIAQAM
MLBr_00855|M.leprae_Br4923          PAVRSASVGVWVGVGSRDEGATVAGAAHFLEHLLFKSTSTRTAMDIAQAI
MAV_3675|M.avium_104                PAVRSASVGVWVGVGSRDEGATVAGAAHFLEHLLFKSTPTRTAVDIAQAM
MAB_3105c|M.abscessus_ATCC_199      PSVRSASVGVWVDVGSRDEGRSVAGAAHFLEHLLFKSTPTRSAADIAQSI
                                    * *:*.******.******* :**************:*.**:* :***::

TH_1284|M.thermoresistible__bu      DAVGGELNAFTAREHTCYYAHVLDADLALAIDLVADVVLNGRCAAADVEL
MSMEG_2657|M.smegmatis_MC2_155      DAVGGELNAFTAREHTCYYAHVLDSDLELAVDLVADVVLRGRCAAEDVEV
Mflv_4022|M.gilvum_PYR-GCK          DAVGGELNAFTSREHTCYYAHVLDSDLELAVDLVADVVLNGRCEPDDVEV
Mvan_2351|M.vanbaalenii_PYR-1       DAVGGELNAFTAREHTCYYAHVLDSDLELAVDLVADVVLNGRCAPGDVEV
Mb2805c|M.bovis_AF2122/97           DAVGGELNAFTAKEHTCYYAHVLGSDLPLAVDLVADVVLNGRCAADDVEV
Rv2782c|M.tuberculosis_H37Rv        DAVGGELNAFTAKEHTCYYAHVLGSDLPLAVDLVADVVLNGRCAADDVEV
MMAR_1926|M.marinum_M               DAVGGELNAFTAKEHTCYYAHVLDNDLELAVELVADVVLNGRCAADDVEL
MLBr_00855|M.leprae_Br4923          DAVGGELNAFTAKEHTCYYAHVLDSDLELAVDLVADVVLNGRCAVDDVEL
MAV_3675|M.avium_104                DAVGGELNAFTAKEHTCYYAHVLDADLELAVDLVADVVLNGRCAAEDVEL
MAB_3105c|M.abscessus_ATCC_199      DAVGGELNAFTAREQTCYYAHVLDSDLELAIDLVADVVLRGRCASDDVEV
                                    ***********::*:********. ** **::*******.***   ***:

TH_1284|M.thermoresistible__bu      ERDVVLEEIAMRDDDPEDSLGDVFLEAMFGRHPVGRPVIGSVETVSAMTR
MSMEG_2657|M.smegmatis_MC2_155      ERDVVLEEIAMRDDDPEDTLGDVFLSAMFGDHPVGRPVIGSIESISEMTR
Mflv_4022|M.gilvum_PYR-GCK          ERDVVLEEIAMRDDDPEDTLGDVFLSAMFGDHPVGRPVVGSVASIAGMTR
Mvan_2351|M.vanbaalenii_PYR-1       ERDVVLEEIAMRDDDPEDTLGDVFLSAMFGDHPVGRPVIGSVESISAMTR
Mb2805c|M.bovis_AF2122/97           ERDVVLEEIAMRDDDPEDALADMFLAALFGDHPVGRPVIGSAQSVSVMTR
Rv2782c|M.tuberculosis_H37Rv        ERDVVLEEIAMRDDDPEDALADMFLAALFGDHPVGRPVIGSAQSVSVMTR
MMAR_1926|M.marinum_M               ERDVVLEEIAMRDDDPEDALADMFLTAMYGDHPVGRPVIGSTQSVSAMTR
MLBr_00855|M.leprae_Br4923          ERDVVLEEIAMRDDDPEDALGDMFLAALFGDHPVGRPVIGTMESVSAMTR
MAV_3675|M.avium_104                ERDVVLEEIAMRDDDPEDALGDMFLGALFGDHPVGRPVIGTARSVASMTR
MAB_3105c|M.abscessus_ATCC_199      ERDVVLEEIAMRDDDPEDLLGEAFLGALFGDHPIGRSVLGSSESISAMTR
                                    ****************** *.: ** *::* **:**.*:*:  ::: ***

TH_1284|M.thermoresistible__bu      AQLHSFHIRRYTPDRMVVAVAGNVDHDEVVALAHRHFGARLVPGRTPVPP
MSMEG_2657|M.smegmatis_MC2_155      AQLHSFHVRRYTPDRMVLAVAGNVDHDEVVALAREHFGRRLVQGRDAVPP
Mflv_4022|M.gilvum_PYR-GCK          SQLHSFHVRRYTPDRMVVAVAGNIEHDEVVRLVRRHFGRHLVRGRSPVAP
Mvan_2351|M.vanbaalenii_PYR-1       SQLHSFHVRRYTPDRMVVAVAGNVEHDMVVKLVREHFGPRLERGRAPVPP
Mb2805c|M.bovis_AF2122/97           AQLQSFHLRRYTPERMVVAAAGNVDHDGLVALVREHFGSRLVRGRRPVAP
Rv2782c|M.tuberculosis_H37Rv        AQLQSFHLRRYTPERMVVAAAGNVDHDGLVALVREHFGSRLVRGRRPVAP
MMAR_1926|M.marinum_M               AQLHSFHMRRYTPDRMVVAVAGNVDHNQVVGLVREHFGPRLVRGRRPVAP
MLBr_00855|M.leprae_Br4923          TQLHSFHVRRYTPERMVVAVAGNVDHDEMVALVREHFGSRLIRGRQSAPP
MAV_3675|M.avium_104                TQLHSFHVRRYTPERMVVAVAGNVDHDEVVAMVREHFGPHLVRGRQPIAP
MAB_3105c|M.abscessus_ATCC_199      AQLHSFHVRRYRPERMVLAVAGNIEHDRVVRLARKYFKSHLDSSVRTVAP
                                    :**:***:*** *:***:*.***::*: :* :.:.:*  :*  .  . .*

TH_1284|M.thermoresistible__bu      RKGASRVPGRPGLRLISRDGEQTHVSLGVRTPGRHWEHRWALSVLNNALG
MSMEG_2657|M.smegmatis_MC2_155      RKGSGRVPGRPSLRVVERDGEQTHVSLGVRTPGRHWEHRWALSVLNTALG
Mflv_4022|M.gilvum_PYR-GCK          RKGAGRVAGRPTLELVKRDAEQTHLSLGVRTPGRHWEHRWALSVLNTALG
Mvan_2351|M.vanbaalenii_PYR-1       RKGAGRVGGQPTLHLVSRDAEQTHLSLGVRTPGRHWDHRWALSVLNSALG
Mb2805c|M.bovis_AF2122/97           RKGTGRVNGSPRLTLVSRDAEQTHVSLGIRTPGRGWEHRWALSVLHTALG
Rv2782c|M.tuberculosis_H37Rv        RKGTGRVNGSPRLTLVSRDAEQTHVSLGIRTPGRGWEHRWALSVLHTALG
MMAR_1926|M.marinum_M               RKGTGRVNGTPQLVLADREAEQTHVSLGVRTPGRGWEHRWALSVLHTALG
MLBr_00855|M.leprae_Br4923          RKSTGRINGGPALTLGKRDAEQTHVLLGVRTPGRSWEHRWALSVLHTALG
MAV_3675|M.avium_104                RKGAGRVNGRPGLLLGTRDAEQTHVSLGVRTPGRGWQHRWALSVLHTALG
MAB_3105c|M.abscessus_ATCC_199      RKGSGRVAAKPGLELVSRDGEQVHLSLGVRTPGRGWQHRWALSVLNSALG
                                    **.:.*: . * * :  *:.**.*: **:***** *:********:.***

TH_1284|M.thermoresistible__bu      GGLSSRLFQEIREQRGLAYSVYSTVDMFADSGALSVYAACQPERFDEVVR
MSMEG_2657|M.smegmatis_MC2_155      GGLSSRLFQEIRETRGLAYSVYSTVDTFSDSGALSIYAGCLPERFEEVVR
Mflv_4022|M.gilvum_PYR-GCK          GGLSSRLFQQIRETRGLAYSVYSTVDTFADTGALSIYAGCQPERFDEVVR
Mvan_2351|M.vanbaalenii_PYR-1       GGLSSRLFQQIRETRGLAYSVYSTVDTFAESGALSIYAGCLPERFDEVVR
Mb2805c|M.bovis_AF2122/97           GGLSSRLFQEVRETRGLAYSVYSALDLFADSGALSVYAACLPERFADVMR
Rv2782c|M.tuberculosis_H37Rv        GGLSSRLFQEVRETRGLAYSVYSALDLFADSGALSVYAACLPERFADVMR
MMAR_1926|M.marinum_M               GGLSSRLFQEIRESRGLAYSVYSALDIFADSGALSVYAACLPERFAEVMR
MLBr_00855|M.leprae_Br4923          GGLSSRLFQEIRETRGLAYSVYSALDIFADSGALSVYAACLPGRFADVMQ
MAV_3675|M.avium_104                GGLSSRLFQEIRELRGLAYSVYSTVDIFADSGALSVYAACQPERFAEVMA
MAB_3105c|M.abscessus_ATCC_199      GGLSSRLFQEIREQRGLVYAVYSTVDTFSDTGALSVYAGCSPERFDEVTK
                                    *********::** ***.*:***::* *:::****:**.* * ** :*  

TH_1284|M.thermoresistible__bu      VTTDVLHRVARDGITEDECRIAKGSLRGGLVLGLEDSASRMHRIGRNELN
MSMEG_2657|M.smegmatis_MC2_155      VTTDVLETVARDGISENECRIAKGSLRGGLVLGLEDSASRMHRIGRAELN
Mflv_4022|M.gilvum_PYR-GCK          VTTDILADVARDGITADECRIAKGSLRGGLVLGLEDSGSRMNRIGRSELN
Mvan_2351|M.vanbaalenii_PYR-1       VTTDVLTEVARDGITADECRIAKGSLRGGLVLGLEDSASRMNRIGRSELN
Mb2805c|M.bovis_AF2122/97           VTADVLESVARDGITEAECGIAKGSLRGGLVLGLEDSSSRMSRLGRSELN
Rv2782c|M.tuberculosis_H37Rv        VTADVLESVARDGITEAECGIAKGSLRGGLVLGLEDSSSRMSRLGRSELN
MMAR_1926|M.marinum_M               VTREVLEAVARDGITESECRIAKGSLRGGLVLGLEDSSSRMSRIGRSELN
MLBr_00855|M.leprae_Br4923          VISEVLASVAGDGITEAECRIAKGSLRGGIILGLEDSNSWMSRLGRSELN
MAV_3675|M.avium_104                VTGGVLESVARDGITESECRIAKGSLRGGLVLGLEDSGSRMSRLGRNELN
MAB_3105c|M.abscessus_ATCC_199      VTSQVLGSVVEDGFTPAEIDRAKGALSGGLVLGLEDSASRMNRLGRSELN
                                    *   :*  *. **::  *   ***:* **::****** * * *:** ***

TH_1284|M.thermoresistible__bu      YGVHQSIDETLARIDAVTAEEVNMVARRLLNRPFGAAVLGPHRSEKSLPQ
MSMEG_2657|M.smegmatis_MC2_155      YGEHRSIEQTLAQIDAVTLDEVNAVARQLLTRDYGAAVLGPDTAKVALPQ
Mflv_4022|M.gilvum_PYR-GCK          FGEHRTIADTLSKIDEVTIDEVNAVARQLLTRPFGAAVLGPVRSKRSLPK
Mvan_2351|M.vanbaalenii_PYR-1       YGKHRSIAETLARIDEVTLEDVNAVARQLLTKPFGAAVLGPVHRKRSLPR
Mb2805c|M.bovis_AF2122/97           YGKHRSIEHTLRQIEQVTVEEVNAVARHLLSRRYGAAVLGPHGSKRSLPQ
Rv2782c|M.tuberculosis_H37Rv        YGKHRSIEHTLRQIEQVTVEEVNAVARHLLSRRYGAAVLGPHGSKRSLPQ
MMAR_1926|M.marinum_M               YGKHRTIEHTLQQIDRVTVDEVNALARRLLVKRYGAAVLGPYTSKRQLPQ
MLBr_00855|M.leprae_Br4923          YGKYRGIEHTLQQIDEVTVEQVNALAHQLLNKRYGAAVLGPYASKKTLPR
MAV_3675|M.avium_104                YGRHRSIEHTLAQIDRVSVDEVNAIARRLLTQRYGAAVLGPYSTKRSLPQ
MAB_3105c|M.abscessus_ATCC_199      NGKHRTISATLDRIDAVTADEVNAIARQLLGGPAGAAVVGPYRSKRTLPR
                                     * :: *  ** :*: *: ::** :*::**    ****:**   :  **:

TH_1284|M.thermoresistible__bu      PLWAIAG---
MSMEG_2657|M.smegmatis_MC2_155      RLQDIAS---
Mflv_4022|M.gilvum_PYR-GCK          PLQQIAG---
Mvan_2351|M.vanbaalenii_PYR-1       PLQRIGS---
Mb2805c|M.bovis_AF2122/97           QLRAMVG---
Rv2782c|M.tuberculosis_H37Rv        QLRAMVG---
MMAR_1926|M.marinum_M               QLRAMVN---
MLBr_00855|M.leprae_Br4923          QLRIMVN---
MAV_3675|M.avium_104                QLRAMVR---
MAB_3105c|M.abscessus_ATCC_199      TLRTMIESTS
                                     *  :