For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. thermoresistible (build 8) TH_1280 (ribF)

annotation: PROBABLE BIFUNCTIONAL FAD SYNTHETASE/RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBF: RIBOFLAVIN KINASE (FLAVOKINASE) + FMN ADENYLYLTRANSFERASE (FAD PYROPHOSPHORYLASE) (FAD SYNTHETASE)(FAD DIPHOSPHORYLASE) (FLAVIN ADENINE DINUCLEOTUDE SYNTHETASE)
coordinates: 2438665 - 2439636
length: 324

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_1280 ribF - 100% (324) PROBABLE BIFUNCTIONAL FAD SYNTHETASE/RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBF: RIBOFLAVIN KINASE (FLAVOKINASE) + FMN ADENYLYLTRANSFERASE (FAD PYROPHOSPHORYLASE) (FAD SYNTHETASE)(FAD DIPHOSPHORYLASE) (FLAVIN ADENINE DINUCLEOTUDE SYNTHETASE)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb2809c ribF 1e-162 84.16% (322) bifunctional riboflavin kinase/FMN adenylyltransferase
M. gilvum PYR-GCK Mflv_4025 - 1e-153 85.90% (305) bifunctional riboflavin kinase/FMN adenylyltransferase
M. tuberculosis H37Rv Rv2786c ribF 1e-162 84.16% (322) bifunctional riboflavin kinase/FMN adenylyltransferase
M. leprae Br4923 MLBr_00852 ribF 1e-157 82.61% (322) bifunctional riboflavin kinase/FMN adenylyltransferase
M. abscessus ATCC 19977 MAB_3109c - 1e-153 80.19% (323) bifunctional riboflavin kinase/FMN adenylyltransferase
M. marinum M MMAR_1921 ribF 1e-160 84.47% (322) bifunctional fad synthetase/riboflavin biosynthesis protein
M. avium 104 MAV_3678 ribF 1e-154 87.21% (305) bifunctional riboflavin kinase/FMN adenylyltransferase
M. smegmatis MC2 155 MSMEG_2653 ribF 1e-164 86.60% (321) bifunctional riboflavin kinase/FMN adenylyltransferase
M. ulcerans Agy99 MUL_2146 ribF 1e-160 84.16% (322) bifunctional riboflavin kinase/FMN adenylyltransferase
M. vanbaalenii PYR-1 Mvan_2348 - 1e-163 85.09% (322) bifunctional riboflavin kinase/FMN adenylyltransferase

CLUSTAL 2.0.9 multiple sequence alignment


Mb2809c|M.bovis_AF2122/97           -MRRRLAIVQRWRGQDEIPTDWGRCVLTIGVFDGVHRGHAELIAHAVKAG
Rv2786c|M.tuberculosis_H37Rv        -MRRRLAIVQRWRGQDEIPTDWGRCVLTIGVFDGVHRGHAELIAHAVKAG
MMAR_1921|M.marinum_M               --------MQRWRGQDEIPTDWGRCVLTVGVFDGVHRGHAELIAHAVKAG
MUL_2146|M.ulcerans_Agy99           --------MQRWRGQDEIPTDWGRCVLTVGVFDGVHRGHAELIAHAVKAG
MAV_3678|M.avium_104                -------------------------MLTIGVFDGVHRGHAELIAHAVKAG
MLBr_00852|M.leprae_Br4923          MGSRRLAIVQRWRGQDEIPTDWGRCVLTIGVFDGVHRGHTELIAHTVQTG
TH_1280|M.thermoresistible__bu      --------VQRWRGQEEIPTDWGRCVLTIGVFDGVHRGHTELIGQAVKSG
Mflv_4025|M.gilvum_PYR-GCK          -------------------------MVTIGVFDGVHRGHQELIGRAVKAG
Mvan_2348|M.vanbaalenii_PYR-1       --------MQRWRGQDEIPTDWGRCVVTIGVFDGVHRGHQELISRAVKAG
MSMEG_2653|M.smegmatis_MC2_155      --------MQRWRGQDEIPTDWGRCVLTIGVFDGVHRGHAELINHAVKAG
MAB_3109c|M.abscessus_ATCC_199      --------MQRWRGQDEIPSDWGRCVLTIGVFDGVHRGHAELIGRAVKAA
                                                             ::*:********** *** ::*::.

Mb2809c|M.bovis_AF2122/97           RARGVPAVLMTFDPHPMEVVYPGSHPAQLTTLTRRAELVQDLGIEVFLVM
Rv2786c|M.tuberculosis_H37Rv        RARGVPAVLMTFDPHPMEVVYPGSHPAQLTTLTRRAELVQDLGIEVFLVM
MMAR_1921|M.marinum_M               RARGVPTVMMTFDPHPMEVVYPGSHPAQLTTLTRRAELVEELGIDVFLVM
MUL_2146|M.ulcerans_Agy99           RARGVPTVMMTFDPHPMEVVYPGSHPAQLTTLTRRAELVEELGIDVFLVM
MAV_3678|M.avium_104                RARNVPTVLMTFDPHPMEVVYPGSHPAQLTTLTRRAELVEELGIDVFLVM
MLBr_00852|M.leprae_Br4923          RARNVPTVLMTFDPHPMEVVYPGSHPAQLTTLTRRAELIEELGIDVFLVM
TH_1280|M.thermoresistible__bu      RARGVPTVVMTFDPHPMEVVFPGSHPAMLTTLTRRAELIEELGVDVFLVM
Mflv_4025|M.gilvum_PYR-GCK          RSRGVPTVLMTFDPHPMEVVFPGSHPAQLTTLTRRAELVEEMGIDVFLVM
Mvan_2348|M.vanbaalenii_PYR-1       RSRGVPVVLMTFDPHPMEVVFPGSHPAQLTTLTRRAELVEELGIDVFLVM
MSMEG_2653|M.smegmatis_MC2_155      RARGVPVVLMTFDPHPMEVVFPGNHPAQLTTLTRRAELVEELGIDVFLVM
MAB_3109c|M.abscessus_ATCC_199      RELNLKSVLMTFDPHPMEVVFPGTHPAQLTTLTRRAELAEELGVDVFLVV
                                    *  .:  *:***********:**.*** ********** :::*::****:

Mb2809c|M.bovis_AF2122/97           PFTTDFMKLTPDRFIHELLVEHLHVVEVVVGENFTFGKKAAGNVDTLRRA
Rv2786c|M.tuberculosis_H37Rv        PFTTDFMKLTPDRFIHELLVEHLHVVEVVVGENFTFGKKAAGNVDTLRRA
MMAR_1921|M.marinum_M               PFTTDFMKLTPDRFIHELLVEHLHVVEVVVGENFTFGKKAAGSVDTLRHA
MUL_2146|M.ulcerans_Agy99           PFTTDFMKLTPDRFIHELLFEHLHVVEVVVGENFTFGKKAAGSVDTLRHA
MAV_3678|M.avium_104                PFTTDFMKLTPDRYVHELLVENLHVVEVVVGENFTFGKKATGNVETLRRA
MLBr_00852|M.leprae_Br4923          PFTTDFMKLTPDRYVHELLVEHLHVVEVVVGENFTFGKKAAGNVIMLRRA
TH_1280|M.thermoresistible__bu      PFTADFMKLTPERYVHELLVERLHVVEVVVGENFTFGKKAAGNVEMLRQA
Mflv_4025|M.gilvum_PYR-GCK          PFTSDFMKLTPERYVHELLVERLHVVEVVVGDNFTFGKKAAGNVELLRKA
Mvan_2348|M.vanbaalenii_PYR-1       PFTSDFMKLTPERYIHELLVERLHVVEVLVGENFTFGKKAAGNVDLLRKA
MSMEG_2653|M.smegmatis_MC2_155      PFTSDFMKLTPERYIHELLVEHLHVVEVVVGENFTFGKKAAGNVDMLRKA
MAB_3109c|M.abscessus_ATCC_199      PFTPEFMKLSPERYVHELLVERLHVAEVVVGENFTFGKKAAGNVQMLKKA
                                    ***.:****:*:*::****.*.***.**:**:********:*.*  *::*

Mb2809c|M.bovis_AF2122/97           GERFGFAVESMSLVSEHHSNETVTFSSTYIRSCVDAGDMVAAMEALGRPH
Rv2786c|M.tuberculosis_H37Rv        GERFGFAVESMSLVSEHHSNETVTFSSTYIRSCVDAGDMVAAMEALGRPH
MMAR_1921|M.marinum_M               GERFGFAVEAMSLVSEHHSNETVTFSSTYIRSCVDAGDVMAATEALGRPH
MUL_2146|M.ulcerans_Agy99           GERFGFAVEAMSLVSEHHSNETVTFSSTYIRSCVDAGDVMAATEALGRPH
MAV_3678|M.avium_104                GERFGFAVEAMSLLSEHHSNQTVTFSSTYIRSCVDAGDVVAAMEALGRPH
MLBr_00852|M.leprae_Br4923          GQRFGFAVGSMSLLSEHRGNETVAFSSTYIRSCVDAGDMMAATEALGRPH
TH_1280|M.thermoresistible__bu      GERFGFAVTAMSLVSEQTDGQRVTYSSTYIRSCVDAGDVVAAAEALGRPH
Mflv_4025|M.gilvum_PYR-GCK          GDRFGFAVDSLSLVAEHHRDETVTFSSTYIRSCVDAGDMVAAEEALGRPH
Mvan_2348|M.vanbaalenii_PYR-1       GERFGFAVDSLSLVAEHHQDETVAFSSTYIRSCVDAGDMVAAAEALGRPH
MSMEG_2653|M.smegmatis_MC2_155      GERFGFAVEAMSLVAEHHRNETVTFSSTYIRACVDAGDMVAAAEALGRPH
MAB_3109c|M.abscessus_ATCC_199      GERFGFKVDAVTLVTEH----AVTFSSTYIRSCVDAGDMVAATEALGRPH
                                    *:**** * :::*::*:     *::******:******::** *******

Mb2809c|M.bovis_AF2122/97           RVEGVVVRGEGRGAELGFPTANVAPPMYSAIPADGVYAAWFTVLGHGPVT
Rv2786c|M.tuberculosis_H37Rv        RVEGVVVRGEGRGAELGFPTANVAPPMYSAIPADGVYAAWFTVLGHGPVT
MMAR_1921|M.marinum_M               RVEGVVVRGYGRGAELGFPTANVAPPMYSAIPADGVYAAWFTVLGHGPVT
MUL_2146|M.ulcerans_Agy99           RVEGVVVRGYGRGAELGFPTANVAPPMYSAIPADGVYAAWFTVLGHGPVT
MAV_3678|M.avium_104                RVEGVVVRGEGRGIQLGFPTANVAPPMYSAIPADGVYAAWFTVLGHGPVT
MLBr_00852|M.leprae_Br4923          RVEGMVVRGQGRGTELGFPTANVASPMYSATPADGVYAAWFTVLGHGPVT
TH_1280|M.thermoresistible__bu      RVEGVVVRGDGRGRGLGFPTANVAPPMYSAIPADGVYAAWFTVLGHGPVT
Mflv_4025|M.gilvum_PYR-GCK          RVEGVVVRGDGRGRDLGFPTANVAPPMYAAIPADGVYAAWFTVLGHGPVV
Mvan_2348|M.vanbaalenii_PYR-1       RVEGVVVRGDGRGRVLGFPTANVAPPMYSAIPADGVYAAWFTVLGHSPVV
MSMEG_2653|M.smegmatis_MC2_155      RVEGVVVRGDGRGRVLGFPTANVAPPMYSAIPADGVYAAWFTVLGQGPQV
MAB_3109c|M.abscessus_ATCC_199      RVEGVVVRGDGRGRELGFPTANVAPPMFSAIPADGVYAAWFTLLGHGPTM
                                    ****:**** ***  *********.**::* ***********:**:.*  

Mb2809c|M.bovis_AF2122/97           GTVVPGERYQAAVSVGTNPTFSGRTRTVEAFVLDTTADLYGQHVALDFVG
Rv2786c|M.tuberculosis_H37Rv        GTVVPGERYQAAVSVGTNPTFSGRTRTVEAFVLDTTADLYGQHVALDFVG
MMAR_1921|M.marinum_M               GAVIPGERYQAAVSVGTNPTFSGRTRTVEAFVLDTAADLYGQHVALDFVA
MUL_2146|M.ulcerans_Agy99           GAVIPGERYQAAVSVGTNPTFSGRTRTVEAFVLDTAADLYGQHVALDFVA
MAV_3678|M.avium_104                GTVIPGERYQAAVSVGTNPTFSGRTRTVEAFVLDTQADLYGQHVALDFVA
MLBr_00852|M.leprae_Br4923          GTVVPGECYQAAVSVGTNPTFSGRTRTVEAFVLDAVADLYGQHVALDFVG
TH_1280|M.thermoresistible__bu      GTVIPGERYRAAVSIGTNPTFSGRTRTVEAFVLDTEADLYGQHVALDFVA
Mflv_4025|M.gilvum_PYR-GCK          GTVTPGERYQAAVSVGTNPTFSGRTRTVEAFVLDTEADLYGQHVAVDFVA
Mvan_2348|M.vanbaalenii_PYR-1       GTVTPGERYQAAVSVGTNPTFSGRTRTVEAFVLDTSADLYGQHVAVDFVA
MSMEG_2653|M.smegmatis_MC2_155      GTVVPGERYQAAVSVGTNPTFSGRTRTVEAFVLDTFADLYGQHVAVDFVS
MAB_3109c|M.abscessus_ATCC_199      GTVVPGERYQAAVSVGSNPTFSGKARTVEAFILDTTADLYGQHVAVDFVA
                                    *:* *** *:****:*:******::******:**: *********:***.

Mb2809c|M.bovis_AF2122/97           RIRGQKKFESVRQLVAAMGADTERARDLLSTG-
Rv2786c|M.tuberculosis_H37Rv        RIRGQKKFESVRQLVAAMGADTERARDLLSTG-
MMAR_1921|M.marinum_M               RIRGQKKFASVPELVAEIGADTERTRVLLSTG-
MUL_2146|M.ulcerans_Agy99           RIRGQKKFASVPELVAEIGADTERTRVLLSTG-
MAV_3678|M.avium_104                RIRGQHKFDSVDDLVVAMGQDTERARQLLSAG-
MLBr_00852|M.leprae_Br4923          RIRGQRKFDSVADLVAEMEKDIDRARALLAD--
TH_1280|M.thermoresistible__bu      RIRGQEKFDSVDDLIAAMRRDTEQAREILSR--
Mflv_4025|M.gilvum_PYR-GCK          RLRGQEKFGSVADLITAMEGDTERARTILSAQ-
Mvan_2348|M.vanbaalenii_PYR-1       RLRGQEKFDSVADLVTAMGADTERARALLSAH-
MSMEG_2653|M.smegmatis_MC2_155      RIRGQEKFDSVDDLVVAMERDVERARTILRDSV
MAB_3109c|M.abscessus_ATCC_199      RIRSMEKFKSIDDLVVAMGKDAEKARTILARN-
                                    *:*. .** *: :*:. :  * :::* :*

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_1280	ribF	-	100% (324)	PROBABLE BIFUNCTIONAL FAD SYNTHETASE/RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBF: RIBOFLAVIN KINASE (FLAVOKINASE) + FMN ADENYLYLTRANSFERASE (FAD PYROPHOSPHORYLASE) (FAD SYNTHETASE)(FAD DIPHOSPHORYLASE) (FLAVIN ADENINE DINUCLEOTUDE SYNTHETASE)