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aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_1246 | - | 100% (337) | CONSERVED HYPOTHETICAL PROTEIN | |
| M. thermoresistible (build 8) | TH_2316 | - | 1e-53 | 36.15% (390) | conserved hypothetical protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1783c | - | 2e-99 | 52.37% (338) | hypothetical protein Mb1783c |
| M. gilvum PYR-GCK | Mflv_1576 | - | 5e-76 | 42.39% (394) | hypothetical protein Mflv_1576 |
| M. tuberculosis H37Rv | Rv1754c | - | 2e-99 | 52.37% (338) | hypothetical protein Rv1754c |
| M. leprae Br4923 | MLBr_02491 | - | 7e-95 | 50.75% (335) | hypothetical protein MLBr_02491 |
| M. abscessus ATCC 19977 | MAB_3454 | - | 4e-92 | 47.49% (339) | hypothetical protein MAB_3454 |
| M. marinum M | MMAR_2586 | - | 1e-97 | 51.18% (338) | hypothetical protein MMAR_2586 |
| M. avium 104 | MAV_1035 | - | 6e-99 | 52.20% (341) | hypothetical protein MAV_1035 |
| M. smegmatis MC2 155 | MSMEG_4360 | - | 1e-163 | 79.70% (335) | hypothetical protein MSMEG_4360 |
| M. ulcerans Agy99 | MUL_3174 | - | 8e-98 | 51.18% (338) | hypothetical protein MUL_3174 |
| M. vanbaalenii PYR-1 | Mvan_5180 | - | 1e-74 | 41.58% (392) | hypothetical protein Mvan_5180 |
CLUSTAL 2.0.9 multiple sequence alignment
TH_1246|M.thermoresistible__bu --------------------------------------------------
MSMEG_4360|M.smegmatis_MC2_155 --------------------------------------------------
Mb1783c|M.bovis_AF2122/97 --------------------------------------------------
Rv1754c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2586|M.marinum_M --------------------------------------------------
MUL_3174|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02491|M.leprae_Br4923 --------------------------------------------------
MAV_1035|M.avium_104 --------------------------------------------------
MAB_3454|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1576|M.gilvum_PYR-GCK ----------------------------MAWADDGASSASKPSASATSGG
Mvan_5180|M.vanbaalenii_PYR-1 MGAAAYVGRVGGLAVALGVGTAVFAGQGVAWADDTESSTNGASSAATS--
TH_1246|M.thermoresistible__bu --------------------------------------------------
MSMEG_4360|M.smegmatis_MC2_155 --------------------------------------------------
Mb1783c|M.bovis_AF2122/97 ---------------MYRYQVRVQQRRSEMNRWVATRSRRHTYQWITDHK
Rv1754c|M.tuberculosis_H37Rv ---------------MYRYQVRVQQRRSEMNRWVATRSRRHTYQWITDHK
MMAR_2586|M.marinum_M --------------------------------------------------
MUL_3174|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02491|M.leprae_Br4923 --------------------------------------------------
MAV_1035|M.avium_104 --------------------------------------------------
MAB_3454|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1576|M.gilvum_PYR-GCK NTADTQSTTTKPDDATQTDDDTADDTATDDSATDTEELGAEDPDVEEPDI
Mvan_5180|M.vanbaalenii_PYR-1 ---DSVQTDTTSDTVDTPEADTEDETEPDPEPEDQAEPDPEPEDQAEPDP
TH_1246|M.thermoresistible__bu --------------------------------------------------
MSMEG_4360|M.smegmatis_MC2_155 -------------------------MPAFRRLASTSRACVVSAVATTLVG
Mb1783c|M.bovis_AF2122/97 SPRDHYRHISELRTSIATSSPGRCDMSPIPRIVSVSLAWAAAIGLMVPIG
Rv1754c|M.tuberculosis_H37Rv SPRDHYRHISELRTSIATSSPGRCDMSPIPRIVSVSLAWAAAIGLMVPIG
MMAR_2586|M.marinum_M -------------------------MSTIHRLVSLSVASAAAFGFIGAVG
MUL_3174|M.ulcerans_Agy99 -------------------------MSTIHRLVSLSVASAAAFGFIGAVG
MLBr_02491|M.leprae_Br4923 --------------------------------------------------
MAV_1035|M.avium_104 -----------MDVNAVSNPLERCYMSAFLRSVSLSMASAAAVGFVLVVG
MAB_3454|M.abscessus_ATCC_1997 -------------------------MSTR-RRISVVLMTSAVIGSSVAVD
Mflv_1576|M.gilvum_PYR-GCK DSPQVDTDSPDDEVDGPDDEAEPEPAAESDDRTPAKPAGRAERDTEPEAE
Mvan_5180|M.vanbaalenii_PYR-1 EPEPEPQDEPDPDQD-QDQDADDSEGADADQEPPKATETNTETSTKPEPE
TH_1246|M.thermoresistible__bu --------------------------------------------------
MSMEG_4360|M.smegmatis_MC2_155 GLVAGLVGAPPAAADPCS--------VPTPNAS-----------------
Mb1783c|M.bovis_AF2122/97 --LAPPAMAAPCSGDAAN--------APPPPSAIVTDPGA----TALGPV
Rv1754c|M.tuberculosis_H37Rv --LAPPAMAAPCSGDAAN--------APPPPSAIVTDPGA----TALGPV
MMAR_2586|M.marinum_M --LAPMASAVPCSGDAAN--------APPPANAVVTAPSS----KTLG--
MUL_3174|M.ulcerans_Agy99 --LAPMASAVPCSGDAAN--------APPPANAVVTAPSS----KTLG--
MLBr_02491|M.leprae_Br4923 --------------------------------------------------
MAV_1035|M.avium_104 --PAPTANATPCGAPEAN--------VDPPAAPPAMPAPQPVVQP-----
MAB_3454|M.abscessus_ATCC_1997 --VAPVAYADPCAGPAAG--------LQPPTPVPDDGIPG----------
Mflv_1576|M.gilvum_PYR-GCK VEAGPQQTAQTSERDPSDTTATPRDTEDIPSPQTSTTVTVDATAAKATTG
Mvan_5180|M.vanbaalenii_PYR-1 PEPEPEPTEKTTATVTDDGSDDP--AVPPQEPKKVAVFATATSLAESSPK
TH_1246|M.thermoresistible__bu --------------------------------------------------
MSMEG_4360|M.smegmatis_MC2_155 -------ARGLTPSMPDIISKLPVLHLPIGRKPV----------------
Mb1783c|M.bovis_AF2122/97 RPGHGPIPTGRKPRGANDRAPLPKLGPLISALLN---PGARNAAPLQQQA
Rv1754c|M.tuberculosis_H37Rv RPGHGPIPTGRKPRGANDRAPLPKLGPLISALLN---PGARNAAPLQQQA
MMAR_2586|M.marinum_M -----PMTRGLRPRGANERAPLPKLGP-LSRLLN---PGARRSAPVQQQA
MUL_3174|M.ulcerans_Agy99 -----PMTRGLRPRGANERAPLPKLGP-LSRLLN---PGARRSAPVQQQA
MLBr_02491|M.leprae_Br4923 --------------------------------------------------
MAV_1035|M.avium_104 -------PTGRRPTHTNDQAPLPKLGPLISSLLKPSAPGRQYSAPVHPRA
MAB_3454|M.abscessus_ATCC_1997 ----QAPPIGRRPAGANDKAPLPELGKLPLAILKQVLPQQSAKKKPGWAQ
Mflv_1576|M.gilvum_PYR-GCK TASSTLADLSTTEQGPQTADAKPNLITAVVNVVNSMIDWARQKAAADPGD
Mvan_5180|M.vanbaalenii_PYR-1 TLSPKVAALLTTEQDEAAAAKKPNLITAVVNVVTSMLDWARQKADAKPGD
TH_1246|M.thermoresistible__bu --------------------------------------------------
MSMEG_4360|M.smegmatis_MC2_155 ------------------------------------QTASTPEEAKDTAV
Mb1783c|M.bovis_AF2122/97 LVPRANPGP---------------NPAPNPPATG-PQPPNATQLTPNPAP
Rv1754c|M.tuberculosis_H37Rv LVPRANPGP---------------NPAPNPPATG-PQPPNATQLTPNPAP
MMAR_2586|M.marinum_M AVP-----------------------APAPPNPA-NQAPNATQIAPDAAP
MUL_3174|M.ulcerans_Agy99 AVP-----------------------APAPPNPA-NQAPNATQIAPDAAP
MLBr_02491|M.leprae_Br4923 --------------------------------------------------
MAV_1035|M.avium_104 EGPGPDPSAPMYPQA------EVLPPGPNPPTPGGAVPPNANQLRPNAAP
MAB_3454|M.abscessus_ATCC_1997 ELARP--------------------ALPNPPEPG---SPNNLQDQQAAAV
Mflv_1576|M.gilvum_PYR-GCK APQPPFLWALMAFARRELDTLFAAR-TSNSPRSSTAASTSLTLGDAATAA
Mvan_5180|M.vanbaalenii_PYR-1 APQPPFLWALLSFARRELDNLFAARSTTNAPRTTSVTPTSLALTDDATTA
TH_1246|M.thermoresistible__bu --------------------------VDWITG------PNS--TSYTRFG
MSMEG_4360|M.smegmatis_MC2_155 APNTAARAAAEP-------AASTATTVGWVTG------PNS--DSYSRFG
Mb1783c|M.bovis_AF2122/97 APDPAPAAAPD---PGATLAGATTSLAEWVTG------PDSPNKTLERFG
Rv1754c|M.tuberculosis_H37Rv APDPAPAAAPD---PGATLAGATTSLAEWVTG------PDSPNKTLERFG
MMAR_2586|M.marinum_M IPAPAPPPPPDGSDAGGALGGATTSLAEWVTG------PDSPNKTLERFG
MUL_3174|M.ulcerans_Agy99 IPAPAPPPPPDGSDAGGALGGATTSLAEWVTG------PDSPNKTLERFG
MLBr_02491|M.leprae_Br4923 -----------------------------MTG------PNSPNKTLQRFG
MAV_1035|M.avium_104 MPQPQPQPQPAPGPPPPSIAGAPTSLVDWVTG------PNGPNKTLQRFS
MAB_3454|M.abscessus_ATCC_1997 APAP---PAPAVGPAADAAVSPTTSVVGWVTG------VDTGANTLQKFS
Mflv_1576|M.gilvum_PYR-GCK ATAAATTPQPFRSPWLNPQVSASTKFISWVTGAFYDGDYALLANTLKRFN
Mvan_5180|M.vanbaalenii_PYR-1 ALIPS------YSPWLNPQVSPSTRFVSWVTGKYVYLDDDTLANTLARFS
:** : :*.
TH_1246|M.thermoresistible__bu ISGTDLGIMWDNG--------SATEPQVLIAFGDTFGDCGVPGQEWRKNA
MSMEG_4360|M.smegmatis_MC2_155 ISGADLGIMWDNGQ-------TGANRQVLIAFGDTFGNCNVAAQEWRKNT
Mb1783c|M.bovis_AF2122/97 ISGTDLGIPWDNG--------DPANRQVLMIFGDTFGYCAVDGHQWRYNT
Rv1754c|M.tuberculosis_H37Rv ISGTDLGIPWDNG--------DPANRQVLMIFGDTFGYCAVDGHQWRYNT
MMAR_2586|M.marinum_M ISGTDLGILWDNG--------DPANHQVLMAFGDTFGYCAVREHQWRYNT
MUL_3174|M.ulcerans_Agy99 ISGTDLGILWDNG--------DPANHQVLMAFGDTFGYCAVREHQWRYNT
MLBr_02491|M.leprae_Br4923 ISGTDLGIPWDNG--------DPTNHQVLMAFGDSFGYCSVKGQQRRYNI
MAV_1035|M.avium_104 ISGTDLGIAWDNG--------DPANRQVLMAFGDTFGYCKVHGQQWRYNT
MAB_3454|M.abscessus_ATCC_1997 ISGTDLGIMWDNG--------DNAGRQVLMAFGDTYGYCGMKSQQWRYNT
Mflv_1576|M.gilvum_PYR-GCK VYGTDVGVMWDNGMVDDPSTPDIDERQVLIAVGDTFGGPGMTG-RHIYNS
Mvan_5180|M.vanbaalenii_PYR-1 VYGTDVGVMWDNGMVDDPSTPDINEHQILIAVGDTFGAKGMTG-RHIYNT
: *:*:*: **** *:*: .**::* : . *
TH_1246|M.thermoresistible__bu LFRSSDRNLADGMTIPDP--RYGDVYAGSPVTRERPDFSRQVIASLGLAA
MSMEG_4360|M.smegmatis_MC2_155 LFRSADRNLADGMSIPNP--VPGNIYAGSPVDAARPNFSRQVIKSLGLAG
Mb1783c|M.bovis_AF2122/97 LFRSQDRDLGNGVHVTSG--DASNRYSGSPVR--QPGFSKQLINSIKWAR
Rv1754c|M.tuberculosis_H37Rv LFRSQDRDLGNGVHVTSG--DASNRYSGSPVR--QPGFSKQLINSIKWAR
MMAR_2586|M.marinum_M LFRSQDRNLADGLHVTPG--DPVNRYSGSPIS--QPGFSKQIISSIKWAP
MUL_3174|M.ulcerans_Agy99 LFRSQDRNLADGLHVTPG--DPVNRYSGSPIS--QPGFSKQIISSIKWAP
MLBr_02491|M.leprae_Br4923 LFRSSNQDLSHGIRIADG--VPNDKYSGSPVW--TTGLAKQVVNTIHRAP
MAV_1035|M.avium_104 LFRSNDHDLSHGIHIADG--VPNDRYSGSPVW--APGLSKQVVNTIHKAA
MAB_3454|M.abscessus_ATCC_1997 LLRTQDKSLSRGLAVAEG--STTNPYAGSPQS--RPGYSKQIIPPIKWAA
Mflv_1576|M.gilvum_PYR-GCK LFRSSDRDLADGMTIPDGEWFNGNMFGGAPLD--KPDQSRPIIERPAWLP
Mvan_5180|M.vanbaalenii_PYR-1 LFRSSDTDLSDGMTIPDGEWFNGNMFGGAPLD--GPTQARPIINRPSWLP
*:*: : .*. *: :. : :.*:* . :: ::
TH_1246|M.thermoresistible__bu QEVTVIPTAGISV----------GSTQYVNFMSVAQWGAPGQWSTNFSAV
MSMEG_4360|M.smegmatis_MC2_155 TEVTVIPTAGIAV----------GTTQYVNFMSVSRWGAPGQWSTNFSAV
Mb1783c|M.bovis_AF2122/97 DETGIIPTAGIAV----------GKTQYVNFMSIRNWGRDGEWTTNYSGI
Rv1754c|M.tuberculosis_H37Rv DETGIIPTAGIAV----------GKTQYVNFMSIRNWGRDGEWTTNYSGI
MMAR_2586|M.marinum_M DETGIIPTSGIAV----------GKTQYVSFMSIRDWGRDGEWTTNYSGI
MUL_3174|M.ulcerans_Agy99 DETGIIPTSGIAV----------GKTQYVSFMSIRDWGRDGEWTTNYSGI
MLBr_02491|M.leprae_Br4923 HETGIIPTTAISI----------GKTQYMNYMSIKKWGRDGEWTTNYSAI
MAV_1035|M.avium_104 HETGIIPTSGMSM----------GRTQYMSYMSIRQWGRDGEWSTNYSAI
MAB_3454|M.abscessus_ATCC_1997 QERGIIPTAAISV----------GRTQYMNYMSIKSWDSAGEWTTNYSAT
Mflv_1576|M.gilvum_PYR-GCK GSVTLIPTAGVSLPTEVSEDTPFGTIQYVSFMSVTRWGQSGRWSTNYSGI
Mvan_5180|M.vanbaalenii_PYR-1 NSVTLIPTAGVSLPTEVTEDTPFGTIQYVSFMSVSNWGSSGRWTTNYSAI
. :***:.::: * **:.:**: *. *.*:**:*.
TH_1246|M.thermoresistible__bu AVSTDNGETWTVPRESIRPAWFNSVPGVPFIWGYQNFQMGAYLRHN-GYV
MSMEG_4360|M.smegmatis_MC2_155 AVSGDNGETWTVPATSIRPSWFNTVPGVPFVWGDQNFQMAAYLRHN-GYV
Mb1783c|M.bovis_AF2122/97 AVSKDNGQTWGVFPGTIRASGPDSGGKARFVPGNENFQMGAYLKSNDGYL
Rv1754c|M.tuberculosis_H37Rv AVSKDNGQTWGVFPGTIRASGPDSGGKARFVPGNENFQMGAYLKSNDGYL
MMAR_2586|M.marinum_M AVSKDNGQNWGVFPGTIRASGPDSG-RVRFVPGNENFQMGAFVKANDGYL
MUL_3174|M.ulcerans_Agy99 AVSKDNGQNWGVFPGTIRASGPDSG-RVRFVPGNENFQMGAFVKANDGYL
MLBr_02491|M.leprae_Br4923 ARSIDNGQSWGTYPGTIRTASPDAIPGTHFVPGNQNFQMGAFMRGNDGYL
MAV_1035|M.avium_104 ARSTDNGQNWGIFPTSIRTASPDAIPGAGFTPGNENFQMGAFLKGNDGYI
MAB_3454|M.abscessus_ATCC_1997 AVSNDNGQNWKTFPQSIRPASPDAISQVPFTPGNENFQQAAYVKGNDGYI
Mflv_1576|M.gilvum_PYR-GCK AYSTDNGENFTVAPSSVRYNS--------FFSGNRNFQQSAFVKGDDGYV
Mvan_5180|M.vanbaalenii_PYR-1 AYSTDNGENFKVAPESVRYNS--------IFSGNRNFQQSAFVKGDDGYV
* * ***:.: ::* : * .*** .*::: : **:
TH_1246|M.thermoresistible__bu YAYGTGAGRGGMPFLARVPEHSVANLAAYEYHTPFG----------WLRG
MSMEG_4360|M.smegmatis_MC2_155 YAYSTGAGRGGMPFLYRVVETAVADKSAYEYFTPFG----------WIKG
Mb1783c|M.bovis_AF2122/97 YSFGTPPGRGGSAYLARVPQRFVPDLTKYQYWNGDSN-------S-WVPN
Rv1754c|M.tuberculosis_H37Rv YSFGTPPGRGGSAYLARVPQRFVPDLTKYQYWNGDSN-------S-WVPN
MMAR_2586|M.marinum_M YSFGTPPGRGGSAYLARVPQRFVPDLTKYQYWNGDSN-------S-WVAG
MUL_3174|M.ulcerans_Agy99 YSFGTPPGRGGSAYLARVPQRFVPDLTKYQYWNGDSN-------S-WVAG
MLBr_02491|M.leprae_Br4923 YSFGTPSGRSGAAYLARVPQNLVPDLSKYQYWNGN-----------WVPN
MAV_1035|M.avium_104 YQFGTPSGRGGAAFLSRVPPNQLPDLTKYQYWNGDNG-------GHWVAN
MAB_3454|M.abscessus_ATCC_1997 YIFGTPSGRSGSGFVSRALPGNLPDAAKHEFWNTDRG-------T-WVPG
Mflv_1576|M.gilvum_PYR-GCK YMYGTPNGRQGAAYLARVAPEDILNASKYEYYKKASSGWFGGSPARWV-G
Mvan_5180|M.vanbaalenii_PYR-1 YVYGTPNGRQGAAYVARVNNENILDVSEYEYYKAASTGWFGSSEARWVKG
* :.* ** * :: *. : : : ::: . *: .
TH_1246|M.thermoresistible__bu LPFLAIQVVWA------------PSSELSVAWNDYLQKFVMLYTNT-ASS
MSMEG_4360|M.smegmatis_MC2_155 FPFLALQVVWA------------PGSEMSVAWNDHLKKFVMLYTNT-TSS
Mb1783c|M.bovis_AF2122/97 KPDAATPVIPG------------PVGEMSVQYNTYLKQYLALYTNG-MND
Rv1754c|M.tuberculosis_H37Rv KPDAATPVIPG------------PVGEMSVQYNTYLKQYLALYTNG-MND
MMAR_2586|M.marinum_M KPGAATPVIPG------------PVGEMSAQYNTYLKQYLVMYTNG-GND
MUL_3174|M.ulcerans_Agy99 KPGAATPVIPG------------PVGEMSAQYNTYLKQYLVMYTNG-GND
MLBr_02491|M.leprae_Br4923 NPGAATPLFSG------------PVGEMSAQYNDYLKQYIILYSNGDSND
MAV_1035|M.avium_104 NPGAATPIFPG------------PVGEMSAQYNSYLKQYLVLYTDGGSND
MAB_3454|M.abscessus_ATCC_1997 DPNAATPILSG------------PVGEMSAQYNTYLKKYLVMYGDK-SGD
Mflv_1576|M.gilvum_PYR-GCK SPSSASAIIGKSGGLFGFTKPGYTVSEMSVQYNEYLKKYIVLYGDQ-SNN
Mvan_5180|M.vanbaalenii_PYR-1 NPSSASAVIGKTGGACGSTEPGYTVSEMSVQYNEYLQKYIVLYGDQ-FNN
* * :. . .*:*. :* :*:::: :* : ..
TH_1246|M.thermoresistible__bu VVMRTADKPEGPWSAAKTIVTSTQVPGGIYAPYIHPWS-----KGRDLYF
MSMEG_4360|M.smegmatis_MC2_155 VVMRTADKPEGPWSRAKTIVSSTAVPGGIYAPYIHPWS-----EGKDLYF
Mb1783c|M.bovis_AF2122/97 VVARTAPAPQGPWSAEQMLVSSWQMPGGIYAPMMHPWS-----TGKDVYF
Rv1754c|M.tuberculosis_H37Rv VVARTAPAPQGPWSAEQMLVSSWQMPGGIYAPMMHPWS-----TGKDVYF
MMAR_2586|M.marinum_M VVARTAPTPQGPWSPEQMLVSSWQMPGGIYAPMMHPWS-----TGKDVYF
MUL_3174|M.ulcerans_Agy99 VVARTAPTPQGPWSPEQMLVSSWQMPGGIYAPMMHPWS-----TGKDVYF
MLBr_02491|M.leprae_Br4923 VVARTAPAPQGPWSPEQPLVSSFQMPGGIYAPMIHPWS-----SGRDLYF
MAV_1035|M.avium_104 VVARTAPTPQGPWSPEQPLVSSFQMPGGIYAPMIHPWS-----SGRDLYF
MAB_3454|M.abscessus_ATCC_1997 VLLSTSPAPQGPWSPPQIIVTESQMPGGPYAPYLHPWT-----TGKELYF
Mflv_1576|M.gilvum_PYR-GCK IVMRTSDTPEGGWSDATVLMR--QQTGGIYAPMLHPWSPSTEGTGSTLYW
Mvan_5180|M.vanbaalenii_PYR-1 IVMRTSDTPEGAWSDATVLMG--QQSGGIYAPMLHPWSPSTQGTGSDLYW
:: *: *:* ** :: .** *** :***: * :*:
TH_1246|M.thermoresistible__bu TLSLWSTYSVMLMRTTLQK-
MSMEG_4360|M.smegmatis_MC2_155 TLSRWSDYSVMLMRTSLSTS
Mb1783c|M.bovis_AF2122/97 NLSLWSAYNVMLMHTVLP--
Rv1754c|M.tuberculosis_H37Rv NLSLWSAYNVMLMHTVLP--
MMAR_2586|M.marinum_M NLSLWSAYNVMLMHTELA--
MUL_3174|M.ulcerans_Agy99 NLSLWSAYNVMLMHTELA--
MLBr_02491|M.leprae_Br4923 NLSLWSAYDVVLMHTVLP--
MAV_1035|M.avium_104 NLSLWSAYDVMLMHTVLP--
MAB_3454|M.abscessus_ATCC_1997 NLSLWSAYNVMLMRTTLP--
Mflv_1576|M.gilvum_PYR-GCK NLSLWSEYNIMLMETDLSKI
Mvan_5180|M.vanbaalenii_PYR-1 NLSLWSDYNVMLMKTDLTKL
.** ** *.::**.* *