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M. thermoresistible (build 8) TH_1216 ()

annotation: POSSIBLE TRANSMEMBRANE ACYLTRANSFERASE
coordinates: 2330588 - 2331286
length: 233

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1216-100% (233)POSSIBLE TRANSMEMBRANE ACYLTRANSFERASE

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0115-1e-8367.34% (199) transmembrane acyltransferase
M. gilvum PYR-GCKMflv_1859-2e-8669.31% (202) acyltransferase 3
M. tuberculosis H37RvRv0111-1e-8367.34% (199) transmembrane acyltransferase
M. leprae Br4923MLBr_02670-3e-8264.82% (199) hypothetical protein MLBr_02670
M. abscessus ATCC 19977-----
M. marinum MMMAR_0312-2e-8164.82% (199) transmembrane acyltransferase
M. avium 104MAV_5201-2e-8567.84% (199) putative acyltransferase
M. smegmatis MC2 155MSMEG_5537-2e-8669.57% (207) integral membrane protein
M. ulcerans Agy99MUL_4810-1e-8164.82% (199) transmembrane acyltransferase
M. vanbaalenii PYR-1Mvan_4875-1e-8871.14% (201) acyltransferase 3

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_0312|M.marinum_M               --------------MRRAGRTAIWDRAGRQR-----GIPALDGLRAVAVA
MUL_4810|M.ulcerans_Agy99           --------------MRRAGRTAIWDRAGRQR-----GIPALDGLRAVAVA
MAV_5201|M.avium_104                --------------MRRVGRLAIWDRPERRS-----GIPALDGLRAIAVA
Mb0115|M.bovis_AF2122/97            MPARSVPRPRWVAPVRRVGRLAVWDRPERRS-----GIPALDGLRAIAVA
Rv0111|M.tuberculosis_H37Rv         MPARSVPRPRWVAPVRRVGRLAVWDRPERRS-----GIPALDGLRAIAVA
MLBr_02670|M.leprae_Br4923          --------------MRRVGLLRIWNQPERRN-----GIPALDGLRAIAVA
Mflv_1859|M.gilvum_PYR-GCK          --------------MTAVSAAPIRVGPRRYVGPGQ-SIPALDGVRAIAVA
Mvan_4875|M.vanbaalenii_PYR-1       --------------MTAVSAAPIRVGPRRYVGPGQ-AIPALDGVRAIAVA
MSMEG_5537|M.smegmatis_MC2_155      -----------------MTAAPVRAAGRRRTLPARGEIPALDGIRAIAVL
TH_1216|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_0312|M.marinum_M               LVLVGHGGVPGVGGGFIGVDIFFVLSGFLITSLLLDELGRSGRIDLTGFW
MUL_4810|M.ulcerans_Agy99           LVLVGHGGVPGVGGGFIGVDVFFVLSGFLITSLLLDELGRSGRIDLTGFW
MAV_5201|M.avium_104                LVLIGHGGIPGVSGGFIGVDVFFVLSGFLITSLLLDELGRTGRIELTGFW
Mb0115|M.bovis_AF2122/97            LVLASHGGIPGMGGGFIGVDAFFVLSGFLITSLLLDELGRTGRIDLSGFW
Rv0111|M.tuberculosis_H37Rv         LVLASHGGIPGMGGGFIGVDAFFVLSGFLITSLLLDELGRTGRIDLSGFW
MLBr_02670|M.leprae_Br4923          LVLTQHGGIPGLSGGFIGVDLFFVLSGFLITSLLLDELRHTGRIDAINFW
Mflv_1859|M.gilvum_PYR-GCK          LVLADHGGVPGLSGGFLGVDVFFVLSGFLITSLLLDEIGRTGRVGLKGFW
Mvan_4875|M.vanbaalenii_PYR-1       LVLADHGGVPGLSGGFLGVDVFFVLSGFLITSLLLDEVGRTGRIGLKGFW
MSMEG_5537|M.smegmatis_MC2_155      LVLAGHAGVPGVAGGFIGVDIFFVLSGFLITSLLLDEFARTGRVDLKGFW
TH_1216|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_0312|M.marinum_M               IRRARRLLPALVLMVLTVAAARELLPYQALTGLRNDALAAFLWMANWRFV
MUL_4810|M.ulcerans_Agy99           IRRARRLLPALVLMVLTVAAARELLPYQALTGLRNDALAAFLWMANWRFV
MAV_5201|M.avium_104                IRRARRLLPALVLMVLTVAAARQLLPERSLTGLRDDAIAAFLWMANWRFV
Mb0115|M.bovis_AF2122/97            IRRARRLLPALVLMVLTVSAARALFPDQALTGLRSDAIAAFLWTANWRFV
Rv0111|M.tuberculosis_H37Rv         IRRARRLLPALVLMVLTVSAARALFPDQALTGLRSDAIAAFLWTANWRFV
MLBr_02670|M.leprae_Br4923          IRRACRLLPALVLMVLTVGIARELFPYQALTNLRNDAIATFLWVANWRFV
Mflv_1859|M.gilvum_PYR-GCK          IRRARRLLPALVVMVLAVVAVRGLFSDESVANLRDDAVATFFWMSNWIFV
Mvan_4875|M.vanbaalenii_PYR-1       IRRARRLLPALLVMVLAVVALRELFSEESTANLREDAVAAFFWMSNWVFV
MSMEG_5537|M.smegmatis_MC2_155      IRRARRLLPALLVMTLAVVAARELFPPDAVTSLRDDAVAAFFWVANWAFV
TH_1216|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_0312|M.marinum_M               AQKTDYFTQGAPPSPLQHTWSLGVEEQYYIVWPLLLIAVTLLLAARARRY
MUL_4810|M.ulcerans_Agy99           AQKTDYFTQGVPPSPLQHTWSLGVEEQYYIVWPLLLIAVTLLLAARARRY
MAV_5201|M.avium_104                AQKTDYFTQGAPPSPLQHTWSLGVEEQYYFVWPLLLIAVALALAARARRR
Mb0115|M.bovis_AF2122/97            AQNTDYFTQGAPPSPLQHTWSLGVEEQYYVVWPLLLIGATLLLAARARRR
Rv0111|M.tuberculosis_H37Rv         AQNTDYFTQGAPPSPLQHTWSLGVEEQYYVVWPLLLIGATLLLAARARRR
MLBr_02670|M.leprae_Br4923          VHKADYFTQGTPPSPLQHAWSLGVEEQYYLVWPLLLIAVTLLLAARARRR
Mflv_1859|M.gilvum_PYR-GCK          AQDTDYFSQGAPPSPLQHTWSLAVEEQYYVLWPLLIAAVIAGLTALAYRR
Mvan_4875|M.vanbaalenii_PYR-1       AQHTDYFSQGAPPSPLQHTWSLAVEEQFYVLWPLLIAAVLAGLAALAYRR
MSMEG_5537|M.smegmatis_MC2_155      AQQADYFSQGAPPSPLQHTWSLGVEEQYYLVWPLLVLFAVL----LLRRR
TH_1216|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_0312|M.marinum_M               FQRATLGGVRFTIFVIGTLGALASGAAAIVFASESTRDRIYFGTDTRAQA
MUL_4810|M.ulcerans_Agy99           FQRATLGGVRFTIFVIGTLGALASGAAAIVFASESTRDRIYFGTDTRAQA
MAV_5201|M.avium_104                CTRATVGGVRFSAFVIATVGALASAAVAIVMAADGTRDRIYFGTDTRAQA
Mb0115|M.bovis_AF2122/97            CRRATVGGVRFAAFLIASLGTMASATAAVAFTSAATRDRIYFGTDTRAQA
Rv0111|M.tuberculosis_H37Rv         CRRATVGGVRFAAFLIASLGTMASATAAVAFTSAATRDRIYFGTDTRAQA
MLBr_02670|M.leprae_Br4923          CRYATLGAVRLAVFVLASLGALASATVAIARVCDVTRDRIYFGTDTRAQA
Mflv_1859|M.gilvum_PYR-GCK          GMTLSQRAVRTAVFLLATAGIVASATATALMSSDGNLNRVYFGTDTRVQA
Mvan_4875|M.vanbaalenii_PYR-1       GVPLSQRVVRTAVFVLAAGGVVASATATFFLSSDATLNRVYFGTDTRVQA
MSMEG_5537|M.smegmatis_MC2_155      GA----RAVRIAVVVIATAGAAASAACAIVAVNTDTLNRVYFGTDFRAQG
TH_1216|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_0312|M.marinum_M               LLVGAAAAALLVRDWTALNHGWCLVRTRWGRRVARFLPVIGVAGLAALTH
MUL_4810|M.ulcerans_Agy99           LLVGAAAAALLVRDWTALNHGWCLVRTRWGRRVARFLPVIGVAGLAALTH
MAV_5201|M.avium_104                LLVGAAAAALLVSDWPSMNRGWCMLRTRWARRVARILPVLGLAGLAAATH
Mb0115|M.bovis_AF2122/97            LLIGSAAAALLVRDWPSLNRGWCLIRTRWGRRIARLLPFVGLAGLAVTTH
Rv0111|M.tuberculosis_H37Rv         LLIGSAAAALLVRDWPSLNRGWCLIRTRWGRRIARLLPFVGLAGLAVTTH
MLBr_02670|M.leprae_Br4923          LLVGAAASALLVRDWPSLNRGWCLIRTRWGQLIARFLPVLGLAGLAAATH
Mflv_1859|M.gilvum_PYR-GCK          LLVGAAAAALLVRDWRGLTAGLEIFRSRWARWVAWSLPVVGLVVLFLAAR
Mvan_4875|M.vanbaalenii_PYR-1       LLVGAAAAALVVRDWRGLTAGLVIFRSRWARWVAWSLPAVGLVVLFSAAR
MSMEG_5537|M.smegmatis_MC2_155      LLLGAAAAALLVRDWSALTVSGTLIRARWRRWIAWVLPVFGLAVLGAAAH
TH_1216|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_0312|M.marinum_M               FATGNVNEFRHGLLILVALAAVFVVAPVALEQRGAVARLLAWRPLVWLGT
MUL_4810|M.ulcerans_Agy99           FATGNVNEFRHGLLILVALAAVFVVAPVALEQRGAVARLLAWRPLVWLGT
MAV_5201|M.avium_104                CASGASGEFRHGLLIGVAIAAVAVIAPVAVEQRGVVARVLALPPLVWLGT
Mb0115|M.bovis_AF2122/97            VATGSVGEFRHGLLIVVAGAAVIVVASVAMEQRGAVARILAWRPLVWLGT
Rv0111|M.tuberculosis_H37Rv         VATGSVGEFRHGLLIVVAGAAVIVVASVAMEQRGAVARILAWRPLVWLGT
MLBr_02670|M.leprae_Br4923          YATGGAGDFRHGLLIGVAIAAVIVIAPVALEQRGTVARLLALRPLVWLGT
Mflv_1859|M.gilvum_PYR-GCK          IATGSVEEFRSGLLIVVALAAVLVIAPVALAQDGPVARLLSVWPLVGLGA
Mvan_4875|M.vanbaalenii_PYR-1       MATGSAAEFRSGLLIVVALAAVLVIAPVALAQDGPVARLLSAGPLVGLGA
MSMEG_5537|M.smegmatis_MC2_155      LATGDAEDFRHGLLIIVAAAAVLVIVPVALDQYGWVARALGWRPLVALGA
TH_1216|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_0312|M.marinum_M               ISYGIYLWHWPIFLALNGERTGWTGMRLFAARCALTVAIAALSWWLFEQP
MUL_4810|M.ulcerans_Agy99           ISYGIYLWHLPIFLALNGERTGWTGMRLFAARCALTVAIAALSWWLFEQP
MAV_5201|M.avium_104                ISYGVYLWHWPIFLALNGERTGWAGMPLFAARCAATVAVAAASWWLLEQP
Mb0115|M.bovis_AF2122/97            ISYGVYLWHWPIFLALNGQRTGWSGPALFAARCAATVVLAGASWWLIEQP
Rv0111|M.tuberculosis_H37Rv         ISYGVYLWHWPIFLALNGQRTGWSGPALFAARCAATVVLAGASWWLIEQP
MLBr_02670|M.leprae_Br4923          ISYGIYLWHWPIFLALNGERTGWSGVPLFASRCSATVAVAAVSWWLIEQP
Mflv_1859|M.gilvum_PYR-GCK          ISYGVYLWHWPIFLILNGERTGASGWQLFALRCAATIAVAAVSWWLIEQP
Mvan_4875|M.vanbaalenii_PYR-1       ISYGVYLWHWPIFLVLNGERTGIEGWELFALRCAATVAVAAVSWWLIEQP
MSMEG_5537|M.smegmatis_MC2_155      ISYGVYLWHWPLFLILNGERTGLTGWSLVALRFGVTIALAWVSWRFVEQP
TH_1216|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_0312|M.marinum_M               IRRWRPARVPLLPLAAATVASAAAATMLVIPVGTGPGLREVGLPPGVSAV
MUL_4810|M.ulcerans_Agy99           IRRWRPARVPLLPLAAATVASAAAATMLVIPVGNGPGLREVGLPPGVSAV
MAV_5201|M.avium_104                IRRWRPARVPLLPLAAATVASAAAVTLLVVPVGAGPGLREAGLPPGVSAV
Mb0115|M.bovis_AF2122/97            IRRWRPARVPLLPLAAATVASAAAVTMLVVPVGAGPGLREIGLPPGVSAV
Rv0111|M.tuberculosis_H37Rv         IRRWRPARVPLLPLAAATVASAAAVTMLVVPVGAGPGLREIGLPPGVSAV
MLBr_02670|M.leprae_Br4923          IRHWRPVRVPLLPLAAATVASAAAATMWVIPVGTETGLRDIALPPEVSTV
Mflv_1859|M.gilvum_PYR-GCK          VREWRPAFVPMLPLAGATAATAAVLTMTVLPVRVVP--PTPEPGPLVDIA
Mvan_4875|M.vanbaalenii_PYR-1       IREWRPAFVPMLPLAAATAATAAVVTMTVLPVRMVP--ATPEPGPEVDIA
MSMEG_5537|M.smegmatis_MC2_155      VRRWRPQHVPMLPLAAATAATAAVVTLTVVPVTPPQ--PTP-LGPDVMSA
TH_1216|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_0312|M.marinum_M               AAVSPSPPEPAAPGPAAAPRDPNRPFTVSVFGDSIGWTMMHYLPATPGFR
MUL_4810|M.ulcerans_Agy99           AAVSPSPPEPAAPGPAAAPRDPNRPFTVSVFGDSIGWTMMHYLPATPGFR
MAV_5201|M.avium_104                AAVSPSPPGNSRP------RDPNRPFTVSVFGDSIGWTWMHYLPPTPGFA
Mb0115|M.bovis_AF2122/97            AAVSPSPPEASQPAPG--PRDPNRPFTVSVFGDSIGWTLMHYLPPTPGFR
Rv0111|M.tuberculosis_H37Rv         AAVSPSPPEASQPAPG--PRDPNRPFTVSVFGDSIGWTLMHYLPPTPGFR
MLBr_02670|M.leprae_Br4923          AAVSPSPPRGKLSS----TRDPNQPFTVAVFGDSIGWTWMHYLPPTPGFA
Mflv_1859|M.gilvum_PYR-GCK          ALVGPEVPVE---VTRAPTPRAPGDLRVAVFGDSIAWTMMRYLPDTPGVD
Mvan_4875|M.vanbaalenii_PYR-1       ALVGAEVPVE---VTRAPRPSAPGDLRVAVFGDSIAWTLMRYLPETPGLD
MSMEG_5537|M.smegmatis_MC2_155      AAVQPDVGAERPVLGPAPARRAPGTHSVAVFGDSVAWTLMRYLPATPGLA
TH_1216|M.thermoresistible__bu      ---------------------------------------MRYLPPMPGMT
                                                                           *:***  **. 

MMAR_0312|M.marinum_M               FIDHTVIGCSLVRGTPYRYIGQTLEQRPECDTWPSRWSAQVSQDRPDVAL
MUL_4810|M.ulcerans_Agy99           FIDHTVIGCSLVRGTPYRYIGQTLEQRPECDTWPSRWSAQVSQDRPDVAL
MAV_5201|M.avium_104                FLDHTVIGCSLVRGTPYRYIGETLEQRPECDGWPIRWSRQVSQDQPDVAL
Mb0115|M.bovis_AF2122/97            FIDHTVIGCSLVRGTPYRYIGQTLEQRAECDGWPARWSAQVNRDQPDVAL
Rv0111|M.tuberculosis_H37Rv         FIDHTVIGCSLVRGTPYRYIGQTLEQRAECDGWPARWSAQVNRDQPDVAL
MLBr_02670|M.leprae_Br4923          FIDHTVIGCSLVRGTPYQYIGQTLEQRPECDNWPIRWSTQINKDHPNVAL
Mflv_1859|M.gilvum_PYR-GCK          FADFTTIGCGIARGGPYEYVGQELQQKPECDEWPARWAQRIGHQKPDVVL
Mvan_4875|M.vanbaalenii_PYR-1       FADYTTIGCGIARGGPYEYVGQELPQKPECDEWPARWAQRVGHEKPDVVL
MSMEG_5537|M.smegmatis_MC2_155      FSNYTTIGCGIARGGPYRSAGETLNQKPECDTWPARWTQRIRHDRPDTVL
TH_1216|M.thermoresistible__bu      FIDRTTIGCGLARGGPYRQLGETLNQKPECDVWPARWTQRINYDKPDVAL
                                    * : *.***.:.** **.  *: * *:.*** ** **: ::  ::*:..*

MMAR_0312|M.marinum_M               LIIGRWETVDRVNEGKWTHIGDPTFDGYLNFELQRALKIVGSSGVRVMVA
MUL_4810|M.ulcerans_Agy99           LIIGRWETVDRVNEGKWTHIGDPTFDGYLNFELQRALKIVGSSGVRVMVA
MAV_5201|M.avium_104                LIIGRWETVDRVNEGQWTHIGDPTFDAYLNGELERALNIVGSTGVRVVVA
Mb0115|M.bovis_AF2122/97            LIVGRWETVDRVNEGRWTHIGDPTFDAYLNAELQRALSIVGSTGVRVMVT
Rv0111|M.tuberculosis_H37Rv         LIVGRWETVDRVNEGRWTHIGDPTFDAYLNAELQRALSIVGSTGVRVMVT
MLBr_02670|M.leprae_Br4923          LIIGRWETVNRVNEGQWTHIGDPTFDSYLNAELQQALNILGSSGVRVVVA
Mflv_1859|M.gilvum_PYR-GCK          LMVGRWEVVDRMSEGRWTHIGEPGYDAYLRSELNRALDILGSTGARLVVA
Mvan_4875|M.vanbaalenii_PYR-1       LMVGRWEVVDRMMEGQWTHIGEAGYDAYLRGELNRALDILGSTGARVVVT
MSMEG_5537|M.smegmatis_MC2_155      LMIGRWEIVDRKHEGHWTHIGEDAYDDYLTAELQRALDILGSTGARVVVT
TH_1216|M.thermoresistible__bu      LIVGRWEIVDRVFEGRWTHIGDPAYDAYLTGELRRALDIISSTGARVIVT
                                    *::**** *:*  **:*****:  :* **  **.:**.*:.*:*.*::*:

MMAR_0312|M.marinum_M               TVPYSRGGEKPDGRLYPEDQPDRVRQWNDMLRKTVSQHRNVGIIDLNKKL
MUL_4810|M.ulcerans_Agy99           TVPYSRGGEKPDGRLYPEDQPDRVRQWNDMLRKTVSQHRNVGIIDLNKKL
MAV_5201|M.avium_104                TVPYSRGGEKPDGRLYPEDQPDRVNLWNTMLRKTVAHHPNVAILDLNKKL
Mb0115|M.bovis_AF2122/97            TVPYSRGGEKPDGRLYPEDQPERVNKWNAMLHNAISQHSNVGMIDLNKKL
Rv0111|M.tuberculosis_H37Rv         TVPYSRGGEKPDGRLYPEDQPERVNKWNAMLHNAISQHSNVGMIDLNKKL
MLBr_02670|M.leprae_Br4923          TVPYSRGGEKPDGQLYPEDQPDRVNQWNTMLRNTVSQHSNVQILDLNKKL
Mflv_1859|M.gilvum_PYR-GCK          TEPYNRRAEKADGSLYPEDQPDRVERWNTMLREVVDERPNATVLDLNEKL
Mvan_4875|M.vanbaalenii_PYR-1       TEPYNRRAEKPDGSLYPEDQPKRVETWNALLRSVVDKRPNATVLDLNKKL
MSMEG_5537|M.smegmatis_MC2_155      TAPYTRRGERADGSLYPEDQPSRVRAWNTILRDVAAKRPNVSVLDFNAKL
TH_1216|M.thermoresistible__bu      TVPYNRRGEKPDGSLYPEDQPERVDRWNRILRSVVDEYPGVSVLDLNKKL
                                    * **.* .*:.** *******.**  ** :*:..  .  .. ::*:* **

MMAR_0312|M.marinum_M               SPDGVYTAKVDGIQVRSDGVHLTPEGVKWLIPWLEESLR-----------
MUL_4810|M.ulcerans_Agy99           SPDGVYTAKVDGIQVRSDGVHLTPEGVKWLIPWLEESLR-----------
MAV_5201|M.avium_104                CPDGVYTAKVDGIKVRSDGVHLTPEGVKWLTPWLEESLR-----------
Mb0115|M.bovis_AF2122/97            CPDGVYTAKVDGIKVRSDGVHLTQEGVKWLIPWLEDSVRVAS--------
Rv0111|M.tuberculosis_H37Rv         CPDGVYTAKVDGIKVRSDGVHLTQEGVKWLIPWLEDSVRVAS--------
MLBr_02670|M.leprae_Br4923          CPDGVYTAKVDGIKVRSDGVHLTPEGVKWLTPWLEESLK-----------
Mflv_1859|M.gilvum_PYR-GCK          SPNGYYQMRVNGLKVRSDGVHPTPEAVEWMTPWLVEAIRTP---------
Mvan_4875|M.vanbaalenii_PYR-1       SPNGYYQTRVDGIRVRSDGVHPTPEAVEWLTPWLVDALKPE---------
MSMEG_5537|M.smegmatis_MC2_155      NPNGAYTARVDGIRMRSDGVHPTAEAVEWLTPWLVDSLKKLPPGKPR---
TH_1216|M.thermoresistible__bu      GPNGRYTAKVDGVRVRSDGVHFTPEGVEWLAPWLQEAVAPPNTPAPDKPA
                                     *:* *  :*:*:::****** * *.*:*: *** :::            

MMAR_0312|M.marinum_M               ---------------------
MUL_4810|M.ulcerans_Agy99           ---------------------
MAV_5201|M.avium_104                ---------------------
Mb0115|M.bovis_AF2122/97            ---------------------
Rv0111|M.tuberculosis_H37Rv         ---------------------
MLBr_02670|M.leprae_Br4923          ---------------------
Mflv_1859|M.gilvum_PYR-GCK          ---------------------
Mvan_4875|M.vanbaalenii_PYR-1       ---------------------
MSMEG_5537|M.smegmatis_MC2_155      ---------------------
TH_1216|M.thermoresistible__bu      PEPATPKPPHKPPHNNRPVAE