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M. thermoresistible (build 8) TH_1214 (thiD)

annotation: PROBABLE PHOSPHOMETHYLPYRIMIDINE KINASE THID (HMP-PHOSPHATE KINASE) (HMP-P KINASE)
coordinates: 2325306 - 2326142
length: 279

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_1214 thiD - 100% (279) PROBABLE PHOSPHOMETHYLPYRIMIDINE KINASE THID (HMP-PHOSPHATE KINASE) (HMP-P KINASE)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0430c thiD 1e-106 72.45% (265) phosphomethylpyrimidine kinase
M. gilvum PYR-GCK Mflv_0181 - 1e-125 78.18% (275) phosphomethylpyrimidine kinase
M. tuberculosis H37Rv Rv0422c thiD 1e-106 72.45% (265) phosphomethylpyrimidine kinase
M. leprae Br4923 MLBr_00295 thiD 1e-111 70.25% (279) phosphomethylpyrimidine kinase
M. abscessus ATCC 19977 MAB_4197 - 1e-114 73.36% (274) phosphomethylpyrimidine kinase
M. marinum M MMAR_0734 thiD 1e-113 72.83% (276) phosphomethylpyrimidine kinase ThiD
M. avium 104 MAV_4732 thiD 1e-111 72.73% (275) phosphomethylpyrimidine kinase
M. smegmatis MC2 155 MSMEG_0825 thiD 1e-121 76.09% (276) phosphomethylpyrimidine kinase
M. ulcerans Agy99 MUL_3599 thiD 1e-113 72.10% (276) phosphomethylpyrimidine kinase
M. vanbaalenii PYR-1 Mvan_0724 - 1e-127 80.07% (276) phosphomethylpyrimidine kinase

CLUSTAL 2.0.9 multiple sequence alignment


TH_1214|M.thermoresistible__bu      ---------VTYLPLPEPGQTPLRVLTIAGSDSGGGAGIQADLRTFAMLG
MSMEG_0825|M.smegmatis_MC2_155      ---------MKLLPLTPPGQTPTRVMTIAGTDSGGGAGIQADLRTFAMLG
Mflv_0181|M.gilvum_PYR-GCK          MTHSTTATTSSFLPLTPAGQTPLRVLTIAGSDSGGGAGIQADMRTFALLG
Mvan_0724|M.vanbaalenii_PYR-1       ---------MTFLPLTPPGQTPLRVMTIAGSDSGGGAGIQADMRTFALLG
MAB_4197|M.abscessus_ATCC_1997      -------MRSPFLPLPEPGTTPVRAMTIAGSDSGGGAGIQADMRTMALLG
Mb0430c|M.bovis_AF2122/97           -------------------MTPPRVLSIAGSDSGGGAGIQADMRTMALLG
Rv0422c|M.tuberculosis_H37Rv        -------------------MTPPRVLSIAGSDSGGGAGIQADMRTMALLG
MAV_4732|M.avium_104                -----MTGPPPTLPLAPPGTTPRRVLSIAGSDSGGGAGIQADLRTMAMLG
MLBr_00295|M.leprae_Br4923          ---------MNYLPAPPPGTTPLRVLSIAGSDSGGGAGIQADMRTMTVLG
MMAR_0734|M.marinum_M               ---------MSWLPLAPPGATPLRALTIAGSDSGGGAGIQADMRTMALLG
MUL_3599|M.ulcerans_Agy99           ---------MSWLPLAPPGATPLRALTIAGSDSGGGAGIQADMRTMALLG
                                                        ** *.::***:***********:**:::**

TH_1214|M.thermoresistible__bu      VHGLVAVAAVTVQNSVGVSGFHEIPVQVVADQIVAVASDIGLQAAKTGML
MSMEG_0825|M.smegmatis_MC2_155      VHGCVAVAAVTVQNSVGVKGFHEVPVDIIAGQIQVVAEDIGIQAAKTGML
Mflv_0181|M.gilvum_PYR-GCK          VHSLVAVTAVTVQNSLGVKGFHEIPLDVIAGQIEAVASDIGLQAAKTGML
Mvan_0724|M.vanbaalenii_PYR-1       LHGLVAVTAVTVQNSVGVKGFHEIPLDVVAGQIEAVASDIGLQAAKTGML
MAB_4197|M.abscessus_ATCC_1997      VHGCVAVTAVTVQNSLGVKDFHEIPPPIVAAQMEVVITDIGIQAAKTGML
Mb0430c|M.bovis_AF2122/97           VHACVAVTAVTVQNTLGVKDIHEVPNDVVAGQIEAVVTDIGVQAAKTGML
Rv0422c|M.tuberculosis_H37Rv        VHACVAVTAVTVQNTLGVKDIHEVPNDVVAGQIEAVVTDIGVQAAKTGML
MAV_4732|M.avium_104                VHACVAVTAVTAQNTLGVNSFHEVPADVVAGQIEAVAGDIGIQAAKTGML
MLBr_00295|M.leprae_Br4923          VHACTAVTAVTIQNTLGVEGFHEIPAEIVASQIKAVVTDIGIQSAKTGML
MMAR_0734|M.marinum_M               VHACVAVTAVTVQNTLGVKGFHETPEDVVAGQITAVVEDIGIQAAKTGML
MUL_3599|M.ulcerans_Agy99           VHACVVVTAVTVQNTLGVKGFHETPEDVVAGQITAVVEDIGIQAAKTGML
                                    :*. ..*:*** **::**..:** *  ::* *: .*  ***:*:******

TH_1214|M.thermoresistible__bu      ASSEIIETVAETARGQGIGTAVPLVVDPVCASMHGDPLLHMSALDALRTK
MSMEG_0825|M.smegmatis_MC2_155      ASAEIIGAVAETWRG--LGTEAPLVVDPVCASMHGDPLLHPSALDSVRNE
Mflv_0181|M.gilvum_PYR-GCK          ASSEIIETIADTWVAQGLSGTVPLIVDPVCASMHGDPLLHPSALNALKEK
Mvan_0724|M.vanbaalenii_PYR-1       ASSEIIETIADTWVAQGLHGSVPLVVDPVCASMHGDPLLHPSALNALRDK
MAB_4197|M.abscessus_ATCC_1997      ASAPIIEAISESWSN--LAPSVPLVVDPVCASMHGDPLLHPSALDALRTR
Mb0430c|M.bovis_AF2122/97           ASSRIVATVAATWRR--LELSVPLVVDPVCASMHGDPLLAPSALDSLRGQ
Rv0422c|M.tuberculosis_H37Rv        ASSRIVATVAATWRR--LELSVPLVVDPVCASMHGDPLLAPSALDSLRGQ
MAV_4732|M.avium_104                ASSPIIAEVAATWRR--LGLSVPLVVDPVCASMHGDPLLAADALDTLRGQ
MLBr_00295|M.leprae_Br4923          ASSSIIAAVAETWLR--LELTTPLVVDPVCASMHGDPLLTGEAMDSLRDR
MMAR_0734|M.marinum_M               ASPRIIDAVAATWRQ--LEVAVPLVVDPVCASMHGDALLAASGLESLREQ
MUL_3599|M.ulcerans_Agy99           ASPRIIDAVAATWRQ--LEVTVPLVVDPVCASMHGDALLAASGLESLREQ
                                    **. *:  :: :     :   .**:***********.**  ..::::: .

TH_1214|M.thermoresistible__bu      LFPIATLVTPNLDEVRLLVGVDVVDEASQREAAKALHALGPKWVLVKGGH
MSMEG_0825|M.smegmatis_MC2_155      LFPIASLVTPNLDEVRLITGIEVVDEATQRDAAKALHALGPKWALVKGGH
Mflv_0181|M.gilvum_PYR-GCK          LFPLATLVTPNLDEVGLLTGIEVVDEDSQRDAARALHALGPSWALVKGGH
Mvan_0724|M.vanbaalenii_PYR-1       LFPLATLVTPNLDEVRLLVDIDVVDEESQRAAARALHALGPQWALVKGGH
MAB_4197|M.abscessus_ATCC_1997      LFPLATLVTPNLDEVRLLVDIDVVDEDSQKEAARKLHALGPQWALVKGGH
Mb0430c|M.bovis_AF2122/97           LFPLATLLTPNLDEARLLVDIEVVDAESQRAAAKALHALGPQWVLVKGGH
Rv0422c|M.tuberculosis_H37Rv        LFPLATLLTPNLDEARLLVDIEVVDAESQRAAAKALHALGPQWVLVKGGH
MAV_4732|M.avium_104                LFPLATLVTPNLDEVRLLVDIDVTDAASQRDAAKALHALGPQWVLVKGGH
MLBr_00295|M.leprae_Br4923          LFPLATVVTPNLDEVRLLVGIDVVDTESQRAAAMALHALGPQWALVKGGH
MMAR_0734|M.marinum_M               LFPLATLVTPNLDEVRLLVGIDVIDTQSQHAAARALHGLGPRWVLVKGGH
MUL_3599|M.ulcerans_Agy99           LFPLATLVTPNLDEVRLLVGIDVIDTQSQHAAARALHGLGPRWVLVKGGH
                                    ***:*:::******. *:..::* *  :*: **  **.*** *.******

TH_1214|M.thermoresistible__bu      LRSAPHSPDLLFDGAEF----HRFDAPRVDTGHDHGAGDTLAAATAAALA
MSMEG_0825|M.smegmatis_MC2_155      LRTSAQSPDLLYNGTDF----YEFGAERIDTGHDHGAGDTLAAAAACALA
Mflv_0181|M.gilvum_PYR-GCK          LRSSAQSPDLLFDGTDF----HRFDSTRIDTTHDHGAGDTLAAATASALA
Mvan_0724|M.vanbaalenii_PYR-1       LRSSSHSPDLLFDGTDF----HAFDSTRIDTVHDHGAGDTLAAAIACALA
MAB_4197|M.abscessus_ATCC_1997      LRSSDTSTDLLFDGTEF----HYFPVERVDTGHDHGAGDTLAASISCALA
Mb0430c|M.bovis_AF2122/97           LRSSDGSCDLLYDGVSC----YQFDAQRLPTGDDHGGGDTLATAIAAALA
Rv0422c|M.tuberculosis_H37Rv        LRSSDGSCDLLYDGVSC----YQFDAQRLPTGDDHGGGDTLATAIAAALA
MAV_4732|M.avium_104                LRSSQRSCDLLYDGDSC----YEFDAHRLNTGNDHGGGDTLASAVACALA
MLBr_00295|M.leprae_Br4923          LRSSDRSCDLLYGGSSAGVAFHEFDAPRVQTGNDHGGGDTLAAAVSCALA
MMAR_0734|M.marinum_M               LRSSTRSCDLLYDGTDF----FEFDAPRVATGNDHGGGDTLAAATACALA
MUL_3599|M.ulcerans_Agy99           LRSSTRSCDLLYDGTDF----FEFDAPRVATGNDHGGGDTLAAATACALA
                                    **::  * ***:.* .     . *   *: * .***.*****:: :.***

TH_1214|M.thermoresistible__bu      HGHSVPEAVEFAKRWITECLRAAYPLGRGHGPVNPMFRLRG--
MSMEG_0825|M.smegmatis_MC2_155      HGMDMPDAVAFAKGWVTECLRAAYPLGHGHGPVSALFRLHHGS
Mflv_0181|M.gilvum_PYR-GCK          HGYSVPDAVAFAKRWVTECIRSAYPLGQGHGPVSALFRLAP--
Mvan_0724|M.vanbaalenii_PYR-1       HGYPVPDAVAFGKHWVTECLRAAYPLGHGHGPVSALFRLTT--
MAB_4197|M.abscessus_ATCC_1997      HGLPVTEAVAFGKQWITECLKAAYPLGHGHGPVSALFRLDA--
Mb0430c|M.bovis_AF2122/97           HGFTVPDAVDFGKRWVTECLRAAYPLGRGHGPVSPLFRLS---
Rv0422c|M.tuberculosis_H37Rv        HGFTVPDAVDFGKRWVTECLRAAYPLGRGHGPVSPLFRLS---
MAV_4732|M.avium_104                HGFTVPDAVAFGKRWVTECLRASYPLGHGHGPVSALFRLSGDG
MLBr_00295|M.leprae_Br4923          HGYTVPDAVGFGKRWVTECLRDAYPLGRGHGPVSPLFQRT---
MMAR_0734|M.marinum_M               HGFTVPDAVSFAKKWVTECIRAAYPLGRGHGPVSPLFRLS---
MUL_3599|M.ulcerans_Agy99           HGFTVPDAVSFAKKWVTECIRAAYPLGRGHGPVSPLFRLS---
                                    **  :.:** *.* *:***:: :****:*****..:*:

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_1214	thiD	-	100% (279)	PROBABLE PHOSPHOMETHYLPYRIMIDINE KINASE THID (HMP-PHOSPHATE KINASE) (HMP-P KINASE)