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M. thermoresistible (build 8) TH_1119 (menD)

annotation: PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SHCHC SYNTHASE) + 2-OXOGLUTARATE DECARBOXYLASE (ALPHA-KETOGLUTARATE DECARBOXYLASE) (KDC)
coordinates: 2183653 - 2185281
length: 543

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_1119 menD - 100% (543) PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SHCHC SYNTHASE) + 2-OXOGLUTARATE DECARBOXYLASE (ALPHA-KETOGLUTARATE DECARBOXYLASE) (KDC)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0570 menD 0.0 83.39% (554) 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-
M. gilvum PYR-GCK Mflv_5263 - 0.0 83.70% (546) 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid
M. tuberculosis H37Rv Rv0555 menD 0.0 83.39% (554) 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-
M. leprae Br4923 MLBr_02270 menD 0.0 80.22% (556) 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-
M. abscessus ATCC 19977 MAB_3933c - 0.0 80.48% (543) 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate
M. marinum M MMAR_0901 menD 0.0 84.12% (548) bifunctional 2-succinyl-6-hydroxy-2,4-
M. avium 104 MAV_4588 - 0.0 85.87% (545) 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid
M. smegmatis MC2 155 MSMEG_1109 - 0.0 84.28% (547) 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid
M. ulcerans Agy99 MUL_0654 menD 0.0 83.76% (548) 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-
M. vanbaalenii PYR-1 Mvan_0975 - 0.0 84.88% (549) 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid

CLUSTAL 2.0.9 multiple sequence alignment


Mb0570|M.bovis_AF2122/97            -MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRL
Rv0555|M.tuberculosis_H37Rv         -MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRL
MMAR_0901|M.marinum_M               -MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRL
MUL_0654|M.ulcerans_Agy99           -MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRL
MLBr_02270|M.leprae_Br4923          -MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADHAGRIRL
MAV_4588|M.avium_104                -MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALADADRAGRIRL
Mflv_5263|M.gilvum_PYR-GCK          MVNPSTAQARVVVDELVRGGVRDVVLCPGSRNAPLAFALHDADRAGRLRL
Mvan_0975|M.vanbaalenii_PYR-1       MVNPSTAQARVVVDELIRGGVRDVVLCPGSRNAPLAFALHDADRAGRLRL
MSMEG_1109|M.smegmatis_MC2_155      MVNPSTTQARIVVDELIRGGVRDVVLCPGSRNAPLAFALSDADRAGRIRL
TH_1119|M.thermoresistible__bu      MVNPSTAQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRAGRLRL
MAB_3933c|M.abscessus_ATCC_199      -MNPSTAQAHAVVDELIRGGVRDVVLCPGSRNAPLAFALHDADKAGRLRL
                                     :****:**: *****:********************** ***::**:**

Mb0570|M.bovis_AF2122/97            HVRIDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVP
Rv0555|M.tuberculosis_H37Rv         HVRIDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVP
MMAR_0901|M.marinum_M               HVRIDERTAGFLAIGLAVGAGAPACVAMTSGTAVANLGPAVVEANYARVP
MUL_0654|M.ulcerans_Agy99           HVRIDERTAGFLAIGLAVGAGAPACVAMTSGTAVANLGPAVVETNYARVP
MLBr_02270|M.leprae_Br4923          HVRIDERTAGYLAIGLAVAAGAPVCVAMTSGTAVANLGPAVVEANYARVP
MAV_4588|M.avium_104                HVRIDERTAGYLAIGLAIAAGAPVCVAMTSGTAVANLGPAVVEANYARVP
Mflv_5263|M.gilvum_PYR-GCK          HVRIDERTAGFLAIGLAVAERAPVCVAMTSGTAVANLGPAVVEANYARVP
Mvan_0975|M.vanbaalenii_PYR-1       HVRIDERTAGFLAIGLAVAERAPVCVAMTSGTAVANLGPAVVEANYARVP
MSMEG_1109|M.smegmatis_MC2_155      HVRIDERTAGYLAIGLAVAERAPVCIAMTSGTAVANLGPAVVEANYARVP
TH_1119|M.thermoresistible__bu      HVRIDERTAGFLAIGLAVAEGAPVCVAMTSGTAVANLGPAVVEANYARVP
MAB_3933c|M.abscessus_ATCC_199      HVRIDERTAGFLAVGLAAASGSPVPVAMTSGTAVANLGPAVVEANYARVP
                                    **********:**:*** .  :*. :*****************:******

Mb0570|M.bovis_AF2122/97            LIVLSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAED----APER
Rv0555|M.tuberculosis_H37Rv         LIVLSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAED----APER
MMAR_0901|M.marinum_M               LIVLSANRPYELLGTGANQTMEQLGYFGTQVRATISLGLAED----AHER
MUL_0654|M.ulcerans_Agy99           LIVLSANRPYELLGTGANQTMEQLGYFGTQVRATISLGLAED----AHER
MLBr_02270|M.leprae_Br4923          LIVLSANRPYELLGTGANQTMEQLGYFGTQVRAAISLGLAED----APER
MAV_4588|M.avium_104                LIVLSANRPYELLGTGANQTMEQLGYFGTQVRAAISLGLAED----APER
Mflv_5263|M.gilvum_PYR-GCK          LIVLTANRPYELLGTGANQTFEQLGYFGTQVRESISLGLAG-----DHAD
Mvan_0975|M.vanbaalenii_PYR-1       LIVLSANRPYELLGTGANQTFEQLGYFGTQVRANISLGLAPESG-ASALN
MSMEG_1109|M.smegmatis_MC2_155      LIVLSANRPYEMLGTGANQTFEQLGYFGTQVRAAISLGLAPDLTGPNAAD
TH_1119|M.thermoresistible__bu      LIVLSANRPYELLGTGANQTFEQLGYFGTQVRATISLGLAP----ETIGD
MAB_3933c|M.abscessus_ATCC_199      LIVLSANRPYELLGTGANQTMEQLGYFGTQVRAAISIGLAEE----GSEK
                                    ****:******:********:***********  **:***          

Mb0570|M.bovis_AF2122/97            TSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPEP-LGA
Rv0555|M.tuberculosis_H37Rv         TSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPEP-LGA
MMAR_0901|M.marinum_M               LDSLNASWRSATCRVLAAAMGSRTANAGPVHFDIPLREPLVPDPEP-HGA
MUL_0654|M.ulcerans_Agy99           LDSLNASWRSATCRMLAAAMGSRTANAGPVHFDIPLREPLVPDPDP-HGA
MLBr_02270|M.leprae_Br4923          LDSLNATWRSATCRVLVAATGSRTANAGPVQFDIPLREPLIPDPEP-HGA
MAV_4588|M.avium_104                LDALNATWRSATCRVLAAATGSRTANAGPVQFDIPLREPLVPDPEP-HGA
Mflv_5263|M.gilvum_PYR-GCK          MGSLNAQWRSATCRVLVAAKGSRSANAGPVQFDIPLREPLVPDADD-GSA
Mvan_0975|M.vanbaalenii_PYR-1       FSALNGQWRSATCRVVVAATGARSANAGPVQFDIPLREPLVPDAQEPAVP
MSMEG_1109|M.smegmatis_MC2_155      LDTLNAQWRSATCRVLVAATGARSANAGPVQFDIPLREPLVPDPAEPAGG
TH_1119|M.thermoresistible__bu      MSTLNAQWRSATCRVLAAATGARTANAGPVQFDIPLREPLVPDPHTTSEG
MAB_3933c|M.abscessus_ATCC_199      IEAQNPHWRSATCRVLAAAKGSRTANAGPVQFDIPLREPLVPDRDG---G
                                      : *  *******::.** *:*:******:*********:**       

Mb0570|M.bovis_AF2122/97            VTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALP
Rv0555|M.tuberculosis_H37Rv         VTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALP
MMAR_0901|M.marinum_M               VTPPGRPEGRPWTYTPPVTFDQPLEIDLSADTVVIAGHGAGVHPNLVQLP
MUL_0654|M.ulcerans_Agy99           VTPPGRPEGRPWTYTPPVTFDQPLEIDLSADTVVIAGHGAGVHPNLVQLP
MLBr_02270|M.leprae_Br4923          ITPQGRPGGKPWTYIPQVTFDQPLEIDLSADTVVIAGHGAGVHPNLTELP
MAV_4588|M.avium_104                PTPAGRPGGRPWTYTPPVSFDQPLDIDLSPDTVVIAGHGAGTHPNLAQLP
Mflv_5263|M.gilvum_PYR-GCK          YAPEGRPGGKEWTYTPAVTFDQPLEIDLTPDTVVIAGHGAGVHPNLAHLP
Mvan_0975|M.vanbaalenii_PYR-1       YAPDGRPDGRPWTYTPPVTFDQPLDIDLTPDTVVIAGHGAGVHPNLAHLP
MSMEG_1109|M.smegmatis_MC2_155      TIPPGRPGGRSWTHTPPVTFDQPLDIDLTPDTVVIAGHGAGEHPNLAELP
TH_1119|M.thermoresistible__bu      PPP-GRPGGRPWTHTPPVSFDQPLDIDLSLDTVVIAGHGAGHHSNLSALP
MAB_3933c|M.abscessus_ATCC_199      PIPAGRPGGAPWTYTPDVTFDEPVEIDLTADTVVIAGHGAATHPNLSMLP
                                      * *** *  **: * *:**:*::***: *****:****. *.**  **

Mb0570|M.bovis_AF2122/97            TVAEPTAPRS--GDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAE
Rv0555|M.tuberculosis_H37Rv         TVAEPTAPRS--GDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAE
MMAR_0901|M.marinum_M               TIAEPTAPAAPSGGNPLHPLALPLLRPRQVIMLGRPTLHRPVSALLADPE
MUL_0654|M.ulcerans_Agy99           TIAEPTAPAAPSGGNPLHPLALPLLRPRQVIMLGRPTLHRPVSALLADPE
MLBr_02270|M.leprae_Br4923          IVAEPTAPFGPYRPYPLHPLALPLLHPKQVIMLGRPTLHRPVSALLADPQ
MAV_4588|M.avium_104                TVAEPTAPAP---DNPLHPLALRLLRPKQVIMLGRPTLHRPVSALLADPQ
Mflv_5263|M.gilvum_PYR-GCK          TVAEPTAPYA---QTPLHPLALSLIRPRQVIMLGRPTLHRSVSTLLADPA
Mvan_0975|M.vanbaalenii_PYR-1       TVAEPTAPAA---QTPLHPLALRMIRPEQVIMLGRPTLHRPVSALLADPA
MSMEG_1109|M.smegmatis_MC2_155      TVAEPTAPPP---ANPLHPLALRLAHPKQVIMLGRPTLHRPVSTLLADPS
TH_1119|M.thermoresistible__bu      TVAEPTAPAP---ENPLHPLALPLLRPQQVIMLGRPTLHRPVSALLADPS
MAB_3933c|M.abscessus_ATCC_199      TVAEPTAPQP---DNPVHPLALTLLHPQQVIMLGRPTLHRQVSSLLADSR
                                     :******       *:***** : :*.************ ** ****. 

Mb0570|M.bovis_AF2122/97            VPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAA
Rv0555|M.tuberculosis_H37Rv         VPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAA
MMAR_0901|M.marinum_M               VPVFALTTGPRWPDVSGNSQATGTRAIVTGTPNPSWLDRCAQMNRHAVAA
MUL_0654|M.ulcerans_Agy99           VPVFALTTGPRWPDVSGNSQATGTRAIVTGTPNPSWLDRCAQMNRHAVAA
MLBr_02270|M.leprae_Br4923          VPVYALTTGPCWPDVSGNSQAAGTRAVTTGTPHPAWLQRCAEMNQHAIST
MAV_4588|M.avium_104                VPVYALTTGPRWPDVSGNSQATGTRAVTTGAPSPAWLHRCEQANRHAVAA
Mflv_5263|M.gilvum_PYR-GCK          VPVFALTTGPRWPDVSGNSQATGTRAVTSGAASPEWLRRCAEVNRHAVEA
Mvan_0975|M.vanbaalenii_PYR-1       VPVFALTTGPRWPDVSGNSQATGTRAVTAGAPAQAWLRRCAEANRHAVDA
MSMEG_1109|M.smegmatis_MC2_155      VPVYALTTGPRWPDVSGNSQATGTRAVTSGAPSAAWLRKCAELNEHAVTA
TH_1119|M.thermoresistible__bu      VPVYALTTGPRWPDVSGNSQATGTRAVVTGEPQPAWLRRCAEVHRHAMSA
MAB_3933c|M.abscessus_ATCC_199      IPVYALTTGPRWPDVSGNSQATGTRAVTSGSPDPAWLQRCAHAHHKALDA
                                    :**:****** **********:****:.:* .   ** :*   :.:*: :

Mb0570|M.bovis_AF2122/97            VREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRG
Rv0555|M.tuberculosis_H37Rv         VREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRG
MMAR_0901|M.marinum_M               VREQLAAHPLTTGLHVAAAVAGALRPGDQLVLGASNPVRDAALVGLDTAG
MUL_0654|M.ulcerans_Agy99           VREQLAAHPLTTGLHVAAAVAGALRPGDQLVLGASNPVRDAALVGLDTAG
MLBr_02270|M.leprae_Br4923          VRSQLAAHPLITGLHVAAAVADALRPGDQLVLGASNPVRDMALVGLSTDG
MAV_4588|M.avium_104                VRGQLAAHPLTTGLHVAAAVADALRPGDQLVLGASNPVRDAALVGLDSHH
Mflv_5263|M.gilvum_PYR-GCK          VRGQLAAHPLTTGLHVAAVVADAVGPGDQLVLGASNPVRDIALVGFNTAD
Mvan_0975|M.vanbaalenii_PYR-1       VRGQLAAHPLTTGLHVAAAVADALRPGDQLVLGASNPVRDIALVGFHTAD
MSMEG_1109|M.smegmatis_MC2_155      VRKQLAAHPMTTGLHVAAAVADALRPGDQLVLGASNPVRDAALVGLRPDG
TH_1119|M.thermoresistible__bu      VREQLAAHPLTTGLHVAAAVVDALRDGDQLVLGASNPVRDAALVGLNARN
MAB_3933c|M.abscessus_ATCC_199      VRGQLSTHPLTTGLHVAAHVCGSLRDGDQLVLGASNPVRDAALVPWGAKD
                                    ** **::**: ******* *  ::  ************** **.   .  

Mb0570|M.bovis_AF2122/97            IRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLT
Rv0555|M.tuberculosis_H37Rv         IRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLT
MMAR_0901|M.marinum_M               LRVRSNRGVAGIDGTVSTAIGAALGYERDHHG--------RTVALIGDLT
MUL_0654|M.ulcerans_Agy99           LRVRSNRGVAGIDGTVSTAIGAALGYERDHHG--------RTVALIGDLT
MLBr_02270|M.leprae_Br4923          IQVRSNRGVAGIDGTVSTAIGAALAYERSPGYAGSTDRPARTVALIGDLA
MAV_4588|M.avium_104                IRVRSNRGVAGIDGTVSTAIGAALAHEAAHDG--------RTVALIGDLT
Mflv_5263|M.gilvum_PYR-GCK          VKVRSNRGVAGIDGTVSTAIGAALAHERATGG--------RTVALIGDLT
Mvan_0975|M.vanbaalenii_PYR-1       VKVRSNRGVAGIDGTVSTAIGAALAHERS-GG--------RTVALIGDLT
MSMEG_1109|M.smegmatis_MC2_155      IKVRSNRGVAGIDGTISTAIGAALAHD----G--------RTVALIGDLT
TH_1119|M.thermoresistible__bu      VAVRSNRGVAGIDGTVSTAIGAALAHQ----G--------RTIALIGDLT
MAB_3933c|M.abscessus_ATCC_199      VRVRSNRGVAGIDGTVSTAIGAALAHRGG-----------RTVALIGDLT
                                    : *************:********.:              **:******:

Mb0570|M.bovis_AF2122/97            FVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI
Rv0555|M.tuberculosis_H37Rv         FVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI
MMAR_0901|M.marinum_M               FVHDSSGLLIGPTEPTPRQLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI
MUL_0654|M.ulcerans_Agy99           FVHDSSGLLIGPTEPTPRQLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI
MLBr_02270|M.leprae_Br4923          FVHDSSGLLIGPTEPTPQQLKIVVSNDNGGGIFELLEQGDPRLSAVSSRI
MAV_4588|M.avium_104                FVHDSSGLLIGPTEPTPRRLTIVVSNDNGGGIFELLEQGDPRFSDVSSRV
Mflv_5263|M.gilvum_PYR-GCK          FVHDSSGLLVGPTEPTPRKLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI
Mvan_0975|M.vanbaalenii_PYR-1       FVHDSSGLLIGPTEPTPRKLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI
MSMEG_1109|M.smegmatis_MC2_155      FVHDSSGLLIGPTEPTPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI
TH_1119|M.thermoresistible__bu      FVHDSSGLLIGPTEPVPHNLTIVVSNDNGGGIFELLEQGDPRFADVSSRI
MAB_3933c|M.abscessus_ATCC_199      FVHDSSGLLIGPTEPRPENLTIVVSNDNGGGIFELLEQGDPRFHDVSSRI
                                    *********:***** *. *.*********************:  ****:

Mb0570|M.bovis_AF2122/97            FGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSS
Rv0555|M.tuberculosis_H37Rv         FGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSS
MMAR_0901|M.marinum_M               FGTPHDVDVGALCRAYHVENRQIEVDQLPAALDEPGSGLRVLEVKADRSS
MUL_0654|M.ulcerans_Agy99           FGTPHDVDVGALCRAYHVENRQIEVDQLPAALDEPGSGLRVLEVKADRSS
MLBr_02270|M.leprae_Br4923          FGTPHDVDVGALCRAYHVEGRQIEVDKLREALDEPGVGMRVLEVKADRSS
MAV_4588|M.avium_104                FGTPHDVDVGALCRAYHVESAQIEVGELAAALDEPGPGMRVLEVKADRSS
Mflv_5263|M.gilvum_PYR-GCK          FGTPHDVDVGALCRAYHVESTQIEAGELAAALAEDFDGMRVLEVKADRSS
Mvan_0975|M.vanbaalenii_PYR-1       FGTPHDVDVGALCRAYHVESRQIEVGELAGALDEDFDGMRVLEVKADRSS
MSMEG_1109|M.smegmatis_MC2_155      FGTPHDVNIGALCHAYHVDYHQIEADALGAALEDPFQGMRVLEVKADRSS
TH_1119|M.thermoresistible__bu      FGTPHDVDVGALCRAYHVESRQLELPELSAALNEPFEGMRVLEVKADRSS
MAB_3933c|M.abscessus_ATCC_199      FGTPHDVDIAALCRAYHVDSQSISVEELGPALDEPARGIRVLEVKADRST
                                    *******::.***:****:  .:.   *  :* :   *:**********:

Mb0570|M.bovis_AF2122/97            LRQLHAAIKAAL
Rv0555|M.tuberculosis_H37Rv         LRQLHAAIKAAL
MMAR_0901|M.marinum_M               LRQLHAAIKAAL
MUL_0654|M.ulcerans_Agy99           LRQLHAAIKAAL
MLBr_02270|M.leprae_Br4923          LRQLHAAITATL
MAV_4588|M.avium_104                LRQLHAAIKAAL
Mflv_5263|M.gilvum_PYR-GCK          LRALHASIKAGL
Mvan_0975|M.vanbaalenii_PYR-1       LRALHASIRANL
MSMEG_1109|M.smegmatis_MC2_155      LRSLHASIKAAL
TH_1119|M.thermoresistible__bu      LRALHASIKAAL
MAB_3933c|M.abscessus_ATCC_199      LRELHAAIRAAL
                                    ** ***:* * *

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_1119	menD	-	100% (543)	PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SHCHC SYNTHASE) + 2-OXOGLUTARATE DECARBOXYLASE (ALPHA-KETOGLUTARATE DECARBOXYLASE) (KDC)