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VNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYLAIGLAIGAG APVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAE DAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPEPLGAVTPPGRPAGKPWTYTP PVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTL HRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAH PLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSS RIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKAAL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0555 | menD | - | 100% (554) | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase |
| M. tuberculosis H37Rv | Rv1820 | ilvG | 2e-05 | 26.12% (134) | hypothetical protein Rv1820 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0570 | menD | 0.0 | 100.00% (554) | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- |
| M. gilvum PYR-GCK | Mflv_5263 | - | 0.0 | 80.87% (554) | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid |
| M. leprae Br4923 | MLBr_02270 | menD | 0.0 | 85.25% (556) | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- |
| M. abscessus ATCC 19977 | MAB_3933c | - | 0.0 | 77.62% (554) | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate |
| M. marinum M | MMAR_0901 | menD | 0.0 | 88.49% (556) | bifunctional 2-succinyl-6-hydroxy-2,4- |
| M. avium 104 | MAV_4588 | - | 0.0 | 88.45% (554) | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid |
| M. smegmatis MC2 155 | MSMEG_1109 | - | 0.0 | 81.22% (559) | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid |
| M. thermoresistible (build 8) | TH_1119 | menD | 0.0 | 83.39% (554) | PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND |
| M. ulcerans Agy99 | MUL_0654 | menD | 0.0 | 87.95% (556) | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- |
| M. vanbaalenii PYR-1 | Mvan_0975 | - | 0.0 | 82.44% (558) | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0555|M.tuberculosis_H37Rv -MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRL
Mb0570|M.bovis_AF2122/97 -MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRL
MMAR_0901|M.marinum_M -MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRL
MUL_0654|M.ulcerans_Agy99 -MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRL
MLBr_02270|M.leprae_Br4923 -MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADHAGRIRL
MAV_4588|M.avium_104 -MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALADADRAGRIRL
Mflv_5263|M.gilvum_PYR-GCK MVNPSTAQARVVVDELVRGGVRDVVLCPGSRNAPLAFALHDADRAGRLRL
Mvan_0975|M.vanbaalenii_PYR-1 MVNPSTAQARVVVDELIRGGVRDVVLCPGSRNAPLAFALHDADRAGRLRL
MSMEG_1109|M.smegmatis_MC2_155 MVNPSTTQARIVVDELIRGGVRDVVLCPGSRNAPLAFALSDADRAGRIRL
TH_1119|M.thermoresistible__bu MVNPSTAQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRAGRLRL
MAB_3933c|M.abscessus_ATCC_199 -MNPSTAQAHAVVDELIRGGVRDVVLCPGSRNAPLAFALHDADKAGRLRL
:****:**: *****:********************** ***::**:**
Rv0555|M.tuberculosis_H37Rv HVRIDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVP
Mb0570|M.bovis_AF2122/97 HVRIDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVP
MMAR_0901|M.marinum_M HVRIDERTAGFLAIGLAVGAGAPACVAMTSGTAVANLGPAVVEANYARVP
MUL_0654|M.ulcerans_Agy99 HVRIDERTAGFLAIGLAVGAGAPACVAMTSGTAVANLGPAVVETNYARVP
MLBr_02270|M.leprae_Br4923 HVRIDERTAGYLAIGLAVAAGAPVCVAMTSGTAVANLGPAVVEANYARVP
MAV_4588|M.avium_104 HVRIDERTAGYLAIGLAIAAGAPVCVAMTSGTAVANLGPAVVEANYARVP
Mflv_5263|M.gilvum_PYR-GCK HVRIDERTAGFLAIGLAVAERAPVCVAMTSGTAVANLGPAVVEANYARVP
Mvan_0975|M.vanbaalenii_PYR-1 HVRIDERTAGFLAIGLAVAERAPVCVAMTSGTAVANLGPAVVEANYARVP
MSMEG_1109|M.smegmatis_MC2_155 HVRIDERTAGYLAIGLAVAERAPVCIAMTSGTAVANLGPAVVEANYARVP
TH_1119|M.thermoresistible__bu HVRIDERTAGFLAIGLAVAEGAPVCVAMTSGTAVANLGPAVVEANYARVP
MAB_3933c|M.abscessus_ATCC_199 HVRIDERTAGFLAVGLAAASGSPVPVAMTSGTAVANLGPAVVEANYARVP
**********:**:*** . :*. :*****************:******
Rv0555|M.tuberculosis_H37Rv LIVLSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAED----APER
Mb0570|M.bovis_AF2122/97 LIVLSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAED----APER
MMAR_0901|M.marinum_M LIVLSANRPYELLGTGANQTMEQLGYFGTQVRATISLGLAED----AHER
MUL_0654|M.ulcerans_Agy99 LIVLSANRPYELLGTGANQTMEQLGYFGTQVRATISLGLAED----AHER
MLBr_02270|M.leprae_Br4923 LIVLSANRPYELLGTGANQTMEQLGYFGTQVRAAISLGLAED----APER
MAV_4588|M.avium_104 LIVLSANRPYELLGTGANQTMEQLGYFGTQVRAAISLGLAED----APER
Mflv_5263|M.gilvum_PYR-GCK LIVLTANRPYELLGTGANQTFEQLGYFGTQVRESISLGLAG-----DHAD
Mvan_0975|M.vanbaalenii_PYR-1 LIVLSANRPYELLGTGANQTFEQLGYFGTQVRANISLGLAPESG-ASALN
MSMEG_1109|M.smegmatis_MC2_155 LIVLSANRPYEMLGTGANQTFEQLGYFGTQVRAAISLGLAPDLTGPNAAD
TH_1119|M.thermoresistible__bu LIVLSANRPYELLGTGANQTFEQLGYFGTQVRATISLGLAP----ETIGD
MAB_3933c|M.abscessus_ATCC_199 LIVLSANRPYELLGTGANQTMEQLGYFGTQVRAAISIGLAEE----GSEK
****:******:********:*********** **:***
Rv0555|M.tuberculosis_H37Rv TSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPEP-LGA
Mb0570|M.bovis_AF2122/97 TSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPEP-LGA
MMAR_0901|M.marinum_M LDSLNASWRSATCRVLAAAMGSRTANAGPVHFDIPLREPLVPDPEP-HGA
MUL_0654|M.ulcerans_Agy99 LDSLNASWRSATCRMLAAAMGSRTANAGPVHFDIPLREPLVPDPDP-HGA
MLBr_02270|M.leprae_Br4923 LDSLNATWRSATCRVLVAATGSRTANAGPVQFDIPLREPLIPDPEP-HGA
MAV_4588|M.avium_104 LDALNATWRSATCRVLAAATGSRTANAGPVQFDIPLREPLVPDPEP-HGA
Mflv_5263|M.gilvum_PYR-GCK MGSLNAQWRSATCRVLVAAKGSRSANAGPVQFDIPLREPLVPDADD-GSA
Mvan_0975|M.vanbaalenii_PYR-1 FSALNGQWRSATCRVVVAATGARSANAGPVQFDIPLREPLVPDAQEPAVP
MSMEG_1109|M.smegmatis_MC2_155 LDTLNAQWRSATCRVLVAATGARSANAGPVQFDIPLREPLVPDPAEPAGG
TH_1119|M.thermoresistible__bu MSTLNAQWRSATCRVLAAATGARTANAGPVQFDIPLREPLVPDPHTTSEG
MAB_3933c|M.abscessus_ATCC_199 IEAQNPHWRSATCRVLAAAKGSRTANAGPVQFDIPLREPLVPDRDG---G
: * *******::.** *:*:******:*********:**
Rv0555|M.tuberculosis_H37Rv VTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALP
Mb0570|M.bovis_AF2122/97 VTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALP
MMAR_0901|M.marinum_M VTPPGRPEGRPWTYTPPVTFDQPLEIDLSADTVVIAGHGAGVHPNLVQLP
MUL_0654|M.ulcerans_Agy99 VTPPGRPEGRPWTYTPPVTFDQPLEIDLSADTVVIAGHGAGVHPNLVQLP
MLBr_02270|M.leprae_Br4923 ITPQGRPGGKPWTYIPQVTFDQPLEIDLSADTVVIAGHGAGVHPNLTELP
MAV_4588|M.avium_104 PTPAGRPGGRPWTYTPPVSFDQPLDIDLSPDTVVIAGHGAGTHPNLAQLP
Mflv_5263|M.gilvum_PYR-GCK YAPEGRPGGKEWTYTPAVTFDQPLEIDLTPDTVVIAGHGAGVHPNLAHLP
Mvan_0975|M.vanbaalenii_PYR-1 YAPDGRPDGRPWTYTPPVTFDQPLDIDLTPDTVVIAGHGAGVHPNLAHLP
MSMEG_1109|M.smegmatis_MC2_155 TIPPGRPGGRSWTHTPPVTFDQPLDIDLTPDTVVIAGHGAGEHPNLAELP
TH_1119|M.thermoresistible__bu PPP-GRPGGRPWTHTPPVSFDQPLDIDLSLDTVVIAGHGAGHHSNLSALP
MAB_3933c|M.abscessus_ATCC_199 PIPAGRPGGAPWTYTPDVTFDEPVEIDLTADTVVIAGHGAATHPNLSMLP
* *** * **: * *:**:*::***: *****:****. *.** **
Rv0555|M.tuberculosis_H37Rv TVAEPTAPRS--GDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAE
Mb0570|M.bovis_AF2122/97 TVAEPTAPRS--GDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAE
MMAR_0901|M.marinum_M TIAEPTAPAAPSGGNPLHPLALPLLRPRQVIMLGRPTLHRPVSALLADPE
MUL_0654|M.ulcerans_Agy99 TIAEPTAPAAPSGGNPLHPLALPLLRPRQVIMLGRPTLHRPVSALLADPE
MLBr_02270|M.leprae_Br4923 IVAEPTAPFGPYRPYPLHPLALPLLHPKQVIMLGRPTLHRPVSALLADPQ
MAV_4588|M.avium_104 TVAEPTAPAP---DNPLHPLALRLLRPKQVIMLGRPTLHRPVSALLADPQ
Mflv_5263|M.gilvum_PYR-GCK TVAEPTAPYA---QTPLHPLALSLIRPRQVIMLGRPTLHRSVSTLLADPA
Mvan_0975|M.vanbaalenii_PYR-1 TVAEPTAPAA---QTPLHPLALRMIRPEQVIMLGRPTLHRPVSALLADPA
MSMEG_1109|M.smegmatis_MC2_155 TVAEPTAPPP---ANPLHPLALRLAHPKQVIMLGRPTLHRPVSTLLADPS
TH_1119|M.thermoresistible__bu TVAEPTAPAP---ENPLHPLALPLLRPQQVIMLGRPTLHRPVSALLADPS
MAB_3933c|M.abscessus_ATCC_199 TVAEPTAPQP---DNPVHPLALTLLHPQQVIMLGRPTLHRQVSSLLADSR
:****** *:***** : :*.************ ** ****.
Rv0555|M.tuberculosis_H37Rv VPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAA
Mb0570|M.bovis_AF2122/97 VPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAA
MMAR_0901|M.marinum_M VPVFALTTGPRWPDVSGNSQATGTRAIVTGTPNPSWLDRCAQMNRHAVAA
MUL_0654|M.ulcerans_Agy99 VPVFALTTGPRWPDVSGNSQATGTRAIVTGTPNPSWLDRCAQMNRHAVAA
MLBr_02270|M.leprae_Br4923 VPVYALTTGPCWPDVSGNSQAAGTRAVTTGTPHPAWLQRCAEMNQHAIST
MAV_4588|M.avium_104 VPVYALTTGPRWPDVSGNSQATGTRAVTTGAPSPAWLHRCEQANRHAVAA
Mflv_5263|M.gilvum_PYR-GCK VPVFALTTGPRWPDVSGNSQATGTRAVTSGAASPEWLRRCAEVNRHAVEA
Mvan_0975|M.vanbaalenii_PYR-1 VPVFALTTGPRWPDVSGNSQATGTRAVTAGAPAQAWLRRCAEANRHAVDA
MSMEG_1109|M.smegmatis_MC2_155 VPVYALTTGPRWPDVSGNSQATGTRAVTSGAPSAAWLRKCAELNEHAVTA
TH_1119|M.thermoresistible__bu VPVYALTTGPRWPDVSGNSQATGTRAVVTGEPQPAWLRRCAEVHRHAMSA
MAB_3933c|M.abscessus_ATCC_199 IPVYALTTGPRWPDVSGNSQATGTRAVTSGSPDPAWLQRCAHAHHKALDA
:**:****** **********:****:.:* . ** :* :.:*: :
Rv0555|M.tuberculosis_H37Rv VREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRG
Mb0570|M.bovis_AF2122/97 VREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRG
MMAR_0901|M.marinum_M VREQLAAHPLTTGLHVAAAVAGALRPGDQLVLGASNPVRDAALVGLDTAG
MUL_0654|M.ulcerans_Agy99 VREQLAAHPLTTGLHVAAAVAGALRPGDQLVLGASNPVRDAALVGLDTAG
MLBr_02270|M.leprae_Br4923 VRSQLAAHPLITGLHVAAAVADALRPGDQLVLGASNPVRDMALVGLSTDG
MAV_4588|M.avium_104 VRGQLAAHPLTTGLHVAAAVADALRPGDQLVLGASNPVRDAALVGLDSHH
Mflv_5263|M.gilvum_PYR-GCK VRGQLAAHPLTTGLHVAAVVADAVGPGDQLVLGASNPVRDIALVGFNTAD
Mvan_0975|M.vanbaalenii_PYR-1 VRGQLAAHPLTTGLHVAAAVADALRPGDQLVLGASNPVRDIALVGFHTAD
MSMEG_1109|M.smegmatis_MC2_155 VRKQLAAHPMTTGLHVAAAVADALRPGDQLVLGASNPVRDAALVGLRPDG
TH_1119|M.thermoresistible__bu VREQLAAHPLTTGLHVAAAVVDALRDGDQLVLGASNPVRDAALVGLNARN
MAB_3933c|M.abscessus_ATCC_199 VRGQLSTHPLTTGLHVAAHVCGSLRDGDQLVLGASNPVRDAALVPWGAKD
** **::**: ******* * :: ************** **. .
Rv0555|M.tuberculosis_H37Rv IRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLT
Mb0570|M.bovis_AF2122/97 IRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLT
MMAR_0901|M.marinum_M LRVRSNRGVAGIDGTVSTAIGAALGYERDHHG--------RTVALIGDLT
MUL_0654|M.ulcerans_Agy99 LRVRSNRGVAGIDGTVSTAIGAALGYERDHHG--------RTVALIGDLT
MLBr_02270|M.leprae_Br4923 IQVRSNRGVAGIDGTVSTAIGAALAYERSPGYAGSTDRPARTVALIGDLA
MAV_4588|M.avium_104 IRVRSNRGVAGIDGTVSTAIGAALAHEAAHDG--------RTVALIGDLT
Mflv_5263|M.gilvum_PYR-GCK VKVRSNRGVAGIDGTVSTAIGAALAHERATGG--------RTVALIGDLT
Mvan_0975|M.vanbaalenii_PYR-1 VKVRSNRGVAGIDGTVSTAIGAALAHERS-GG--------RTVALIGDLT
MSMEG_1109|M.smegmatis_MC2_155 IKVRSNRGVAGIDGTISTAIGAALAHD----G--------RTVALIGDLT
TH_1119|M.thermoresistible__bu VAVRSNRGVAGIDGTVSTAIGAALAHQ----G--------RTIALIGDLT
MAB_3933c|M.abscessus_ATCC_199 VRVRSNRGVAGIDGTVSTAIGAALAHRGG-----------RTVALIGDLT
: *************:********.: **:******:
Rv0555|M.tuberculosis_H37Rv FVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI
Mb0570|M.bovis_AF2122/97 FVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI
MMAR_0901|M.marinum_M FVHDSSGLLIGPTEPTPRQLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI
MUL_0654|M.ulcerans_Agy99 FVHDSSGLLIGPTEPTPRQLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI
MLBr_02270|M.leprae_Br4923 FVHDSSGLLIGPTEPTPQQLKIVVSNDNGGGIFELLEQGDPRLSAVSSRI
MAV_4588|M.avium_104 FVHDSSGLLIGPTEPTPRRLTIVVSNDNGGGIFELLEQGDPRFSDVSSRV
Mflv_5263|M.gilvum_PYR-GCK FVHDSSGLLVGPTEPTPRKLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI
Mvan_0975|M.vanbaalenii_PYR-1 FVHDSSGLLIGPTEPTPRKLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI
MSMEG_1109|M.smegmatis_MC2_155 FVHDSSGLLIGPTEPTPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRI
TH_1119|M.thermoresistible__bu FVHDSSGLLIGPTEPVPHNLTIVVSNDNGGGIFELLEQGDPRFADVSSRI
MAB_3933c|M.abscessus_ATCC_199 FVHDSSGLLIGPTEPRPENLTIVVSNDNGGGIFELLEQGDPRFHDVSSRI
*********:***** *. *.*********************: ****:
Rv0555|M.tuberculosis_H37Rv FGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSS
Mb0570|M.bovis_AF2122/97 FGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSS
MMAR_0901|M.marinum_M FGTPHDVDVGALCRAYHVENRQIEVDQLPAALDEPGSGLRVLEVKADRSS
MUL_0654|M.ulcerans_Agy99 FGTPHDVDVGALCRAYHVENRQIEVDQLPAALDEPGSGLRVLEVKADRSS
MLBr_02270|M.leprae_Br4923 FGTPHDVDVGALCRAYHVEGRQIEVDKLREALDEPGVGMRVLEVKADRSS
MAV_4588|M.avium_104 FGTPHDVDVGALCRAYHVESAQIEVGELAAALDEPGPGMRVLEVKADRSS
Mflv_5263|M.gilvum_PYR-GCK FGTPHDVDVGALCRAYHVESTQIEAGELAAALAEDFDGMRVLEVKADRSS
Mvan_0975|M.vanbaalenii_PYR-1 FGTPHDVDVGALCRAYHVESRQIEVGELAGALDEDFDGMRVLEVKADRSS
MSMEG_1109|M.smegmatis_MC2_155 FGTPHDVNIGALCHAYHVDYHQIEADALGAALEDPFQGMRVLEVKADRSS
TH_1119|M.thermoresistible__bu FGTPHDVDVGALCRAYHVESRQLELPELSAALNEPFEGMRVLEVKADRSS
MAB_3933c|M.abscessus_ATCC_199 FGTPHDVDIAALCRAYHVDSQSISVEELGPALDEPARGIRVLEVKADRST
*******::.***:****: .:. * :* : *:**********:
Rv0555|M.tuberculosis_H37Rv LRQLHAAIKAAL
Mb0570|M.bovis_AF2122/97 LRQLHAAIKAAL
MMAR_0901|M.marinum_M LRQLHAAIKAAL
MUL_0654|M.ulcerans_Agy99 LRQLHAAIKAAL
MLBr_02270|M.leprae_Br4923 LRQLHAAITATL
MAV_4588|M.avium_104 LRQLHAAIKAAL
Mflv_5263|M.gilvum_PYR-GCK LRALHASIKAGL
Mvan_0975|M.vanbaalenii_PYR-1 LRALHASIRANL
MSMEG_1109|M.smegmatis_MC2_155 LRSLHASIKAAL
TH_1119|M.thermoresistible__bu LRALHASIKAAL
MAB_3933c|M.abscessus_ATCC_199 LRELHAAIRAAL
** ***:* * *