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M. thermoresistible (build 8) TH_0546 ()

annotation: PROBABLE METHYLTRANSFERASE
coordinates: 1166582 - 1167259
length: 226

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0546-100% (226)PROBABLE METHYLTRANSFERASE
M. thermoresistible (build 8)TH_2678-1e-2437.84% (185) PUTATIVE O-methyltransferase MdmC

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1252c-9e-9178.67% (211) methyltransferase
M. gilvum PYR-GCKMflv_2199-1e-9781.86% (226) O-methyltransferase family protein
M. tuberculosis H37RvRv1220c-9e-9178.67% (211) methyltransferase
M. leprae Br4923MLBr_01075-1e-8576.21% (206) putative O-methyltransferase
M. abscessus ATCC 19977MAB_1361c-2e-7970.73% (205) O-methyltransferase
M. marinum MMMAR_4217-1e-9175.45% (224) methyltransferase
M. avium 104MAV_1364-2e-8974.11% (224) O-methyltransferase, family protein 3
M. smegmatis MC2 155MSMEG_5073-2e-9784.69% (209) O-methyltransferase, family protein 3
M. ulcerans Agy99MUL_4520-2e-9074.55% (224) methyltransferase
M. vanbaalenii PYR-1Mvan_4497-5e-9679.82% (228) O-methyltransferase family protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2199|M.gilvum_PYR-GCK          MLVCQAYEQTELFLRNSATPFVTSGNRCDSRCTRGRVGDAGDSRWLYAAV
Mvan_4497|M.vanbaalenii_PYR-1       -------------MR----------GRFPRRGPGVSVSRQ-SLLWPYAAG
MSMEG_5073|M.smegmatis_MC2_155      --------------------------------------------------
TH_0546|M.thermoresistible__bu      --------------------------------------------------
MAB_1361c|M.abscessus_ATCC_199      --------------------------------------------------
Mb1252c|M.bovis_AF2122/97           --------------------------------------------------
Rv1220c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_4217|M.marinum_M               --------------------------------------------------
MUL_4520|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01075|M.leprae_Br4923          --------------------------------------------------
MAV_1364|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_2199|M.gilvum_PYR-GCK          MASTDEPAAASGDSTARARQAEAIVNHAEHSISEDAIVAAARERAVDIGA
Mvan_4497|M.vanbaalenii_PYR-1       MASTDEPGVGSGDPTARARQAEAIVNHAEHSISEDAIVAAARERAVDIGA
MSMEG_5073|M.smegmatis_MC2_155      MASS----------------AEAIVTHAERSISEDAIVAAARERADDIGA
TH_0546|M.thermoresistible__bu      MTSTDDPGSRP-LSHPRSDTAQSLLAHAEQSISEDEIVAAARERAHDIGV
MAB_1361c|M.abscessus_ATCC_199      MTSSADRS-----------PVEAMVSHAEGAISEDDIVAAARERAVDLGA
Mb1252c|M.bovis_AF2122/97           ---------MP--GQPAPSRGESLWAHAEGSISEDVILAGARERATDIGA
Rv1220c|M.tuberculosis_H37Rv        ---------MP--GQPAPSRGESLWAHAEGSISEDVILAGARERATDIGA
MMAR_4217|M.marinum_M               MHGTDSSSDTP--GQPAPSRAELLSAHAEGSISEDTILKTARDRAVDIGV
MUL_4520|M.ulcerans_Agy99           MHGTDSSSDTP--GQPAPSRAELLSAHAEGSISEDTILKTARDRAVDIGV
MLBr_01075|M.leprae_Br4923          MYGTGNNAVTP--DQAAASRADSLFAHAEGSISEDAILASARERSEEIGA
MAV_1364|M.avium_104                MDGT--DAEAP--GQTAPSRAESLVAHAEASISEDALLAAARERAVDIGA
                                                         : :  *** :**** ::  **:*: ::*.

Mflv_2199|M.gilvum_PYR-GCK          GAVTPAVGALLCVLAKLTGAKAVVEVGTGAGVSGLWLLSGMREDGVLTTI
Mvan_4497|M.vanbaalenii_PYR-1       GAVSPAVGALLCVLAKLTGARAVVEVGTGAGVSGLWLLSGMREDGVLTTI
MSMEG_5073|M.smegmatis_MC2_155      GAVTPAVGALLSVLARLTGGRAVVEVGTGAGVSGLWLLSGMRDDGVLTTI
TH_0546|M.thermoresistible__bu      GAVTPAVGALLSVLAKVTGAKAVVEVGTGAGISGLWLLSGMRDDGVLTTI
MAB_1361c|M.abscessus_ATCC_199      GPVTPAVGALLSVFARLSGGKAVVEVGTGAGVSGLWLLSGMREDGVLTTI
Mb1252c|M.bovis_AF2122/97           GAVTPAVGALLCLLAKLSGGKAVAEVGTGAGVSGLWLLSGMRDDGVLTTI
Rv1220c|M.tuberculosis_H37Rv        GAVTPAVGALLCLLAKLSGGKAVAEVGTGAGVSGLWLLSGMRDDGVLTTI
MMAR_4217|M.marinum_M               GAVTPAVGALLSMLAKLSGGKAVAEVGTGAGVSGLWLLSGMSDDGVLTTI
MUL_4520|M.ulcerans_Agy99           GAVTPAVGALLSMLAKLSGGKAVAEVGTGAGVSGLWLLSGMSDDGVLTTI
MLBr_01075|M.leprae_Br4923          RAVTPAVGALLSLLTKLSGGKAVAEVGTGAGVSGLWLLSGMSYDGVLTTI
MAV_1364|M.avium_104                GAVTPAVGALLSLLTKLSGGKAIAEVGTGAGVSGLWLLSGMSDDGVLTTI
                                     .*:*******.::::::*.:*:.*******:*********  *******

Mflv_2199|M.gilvum_PYR-GCK          DVEPEHQRIAKQAFSEAGVGPGRTRLISGRAQEVLTRLADESYDLVFIDA
Mvan_4497|M.vanbaalenii_PYR-1       DVEPEHQRIAKQAFSEAGVGPGRTRLISGRAQEVLTRLADESYDLVFIDA
MSMEG_5073|M.smegmatis_MC2_155      DVEPEHQRIAKQGFSEAGVGPGRTRLISGRAQEVLTRLADESYDLVFIDA
TH_0546|M.thermoresistible__bu      DLEPEHQRIAKQAFTEAGVGPGRTRLISGRAQEVLTRLADESYDLVFIDA
MAB_1361c|M.abscessus_ATCC_199      DVEPEHQRSAKQAFSEASIAPSRTRLIGGRAQEVLPRLADESYDLLVIDA
Mb1252c|M.bovis_AF2122/97           DIEPEHLRLARQAFAEAGIGPSRTRLISGRAQEVLTRLADASYDLVFIDA
Rv1220c|M.tuberculosis_H37Rv        DIEPEHLRLARQAFAEAGIGPSRTRLISGRAQEVLTRLADASYDLVFIDA
MMAR_4217|M.marinum_M               DIEPEHLRVAKQAFTEAGIGPSRTRLISGRAQEVLTRLADDSYDLVFVDA
MUL_4520|M.ulcerans_Agy99           DIEPEHLRVAKQAFTEAGIGPSRTRLISGRAQEVLTRLADDSYDLVFVDA
MLBr_01075|M.leprae_Br4923          DIEPEYLRLAKQAFSEAGIGPSRTRLISGRGQDVLTRLADESYDLVFIDA
MAV_1364|M.avium_104                DIEPEYLRLAKQAFAEAGIGPSRTRLIGGRAQEVLTRLADESYDLVFIDA
                                    *:***: * *:*.*:**.:.*.*****.**.*:**.**** ****:.:**

Mflv_2199|M.gilvum_PYR-GCK          APADQPQFVVEGVRLLRPGGAIVVHRAALGGRAGDASAKDSEVSAVREAA
Mvan_4497|M.vanbaalenii_PYR-1       APADQPHFVTEGVRLLRPGGAIVVHRAALGGRAGDATAKDSEVAAVREAA
MSMEG_5073|M.smegmatis_MC2_155      DPVDQPQFVVEGVRLLRSGGAIVVHRAALGGRAGDADARDAEVTAVREAA
TH_0546|M.thermoresistible__bu      DPIDLPQFVTEGVRLLRSGGAIVLHRAGLGGRVGDAGAADAEVSAVREAT
MAB_1361c|M.abscessus_ATCC_199      APADQPDFLAGGIRLLRPGGAVVIHGASAGGRAGDPSANDPDVVGVREAA
Mb1252c|M.bovis_AF2122/97           DPIDQPDYVAEGVRLLRSGGVIVVHRAALGGRAGDPGARDAEVIAVREAA
Rv1220c|M.tuberculosis_H37Rv        DPIDQPDYVAEGVRLLRSGGVIVVHRAALGGRAGDPGARDAEVIAVREAA
MMAR_4217|M.marinum_M               DPIDQPDYVVEGVRLLRSGGVIVVHRAALGGRAGDPAARDAEVTAVREAA
MUL_4520|M.ulcerans_Agy99           DPIDQPDYVVEGVRLLRSGGVIVVHRAALGDRAGDPAVRDAEVTAVREAA
MLBr_01075|M.leprae_Br4923          DPIDQPAYVVEGVRLLRSCGIIVVHRAALGGRAGDPAARDAEVTAVREAA
MAV_1364|M.avium_104                DPIDQPDYVVEGVRLLRPGGVIVVHRAALGGRAGDPAARDAEVVAVREAA
                                     * * * ::. *:****. * :*:* *. *.*.**. . *.:* .****:

Mflv_2199|M.gilvum_PYR-GCK          RLIAEDERLTPVLIPLGDGLLAAARD
Mvan_4497|M.vanbaalenii_PYR-1       RLIAEDDRLTPVLIPLGDGLLAAARD
MSMEG_5073|M.smegmatis_MC2_155      RLIAEDERLTPVLIPLGDGLLAAVRD
TH_0546|M.thermoresistible__bu      RLIAEDERLTPVVIPLGDGLLAAARD
MAB_1361c|M.abscessus_ATCC_199      RIIADDGRFTAVLIPLGDGLLAATRD
Mb1252c|M.bovis_AF2122/97           RLIAEDERLTPALVPLGDGVLAAVRD
Rv1220c|M.tuberculosis_H37Rv        RLIAEDERLTPALVPLGDGVLAAVRD
MMAR_4217|M.marinum_M               RLIAEDERLTPALVPLGDGVLAAVRD
MUL_4520|M.ulcerans_Agy99           RLIAEDERLTPALVPLGDGVLAAVRD
MLBr_01075|M.leprae_Br4923          RLIAENERLTPALVPLGDGLLAAVRE
MAV_1364|M.avium_104                RLIAEDERLTPALVPLGDGILAAVRD
                                    *:**:: *:*..::*****:***.*: