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M. thermoresistible (build 8) TH_0439 (cobH)

annotation: Probable precorrin-8X methylmutase CobH (aka precorrin isomerase)
coordinates: 963852 - 964478
length: 209

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_0439 cobH - 100% (209) Probable precorrin-8X methylmutase CobH (aka precorrin isomerase)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb2091 cobH 3e-94 83.65% (208) precorrin-8X methylmutase
M. gilvum PYR-GCK Mflv_3105 cobH 6e-96 84.13% (208) precorrin-8X methylmutase
M. tuberculosis H37Rv Rv2065 cobH 3e-94 83.65% (208) precorrin-8X methylmutase
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 MAB_2199c cobH 1e-90 81.73% (208) precorrin-8X methylmutase
M. marinum M MMAR_3045 cobH 2e-95 85.10% (208) precorrin-8x methylmutase, CobH
M. avium 104 MAV_2431 - 2e-75 82.08% (173) precorrin-8X methylmutase
M. smegmatis MC2 155 MSMEG_3872 cobH 1e-102 89.90% (208) precorrin-8X methylmutase
M. ulcerans Agy99 MUL_2289 cobH 5e-95 85.10% (208) precorrin-8X methylmutase
M. vanbaalenii PYR-1 Mvan_3430 cobH 7e-96 85.10% (208) precorrin-8X methylmutase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3105|M.gilvum_PYR-GCK          MLDYIRDAAEIYRQSFATIRAEANLARFPEDVARVVVRLIHTCGQVDVAD
Mvan_3430|M.vanbaalenii_PYR-1       MLDYIRDASEIYRQSFATIRAEADLSRFPEDVARVVVRLIHTCGQVDVAE
MAB_2199c|M.abscessus_ATCC_199      MLDYVRDGAEIYRQSFATIRAEADLSAFPDDVARVVVRLIHTCGQVDLPG
TH_0439|M.thermoresistible__bu      VLDYIRDAAEIYRQSFATIRAEADLTRFPADVARVVVRLIHTCGQVDLTE
MSMEG_3872|M.smegmatis_MC2_155      MLDYIRDAAEIYRQSFATIRDEADLSRFPADVSRVVVRLIHTCGQVDVTD
Mb2091|M.bovis_AF2122/97            MLDYLRDAAEIYRRSFAVIRAEADLARFPADVARVVVRLIHTCGQVDVAE
Rv2065|M.tuberculosis_H37Rv         MLDYLRDAAEIYRRSFAVIRAEADLARFPADVARVVVRLIHTCGQVDVAE
MAV_2431|M.avium_104                -----------------------------------MVRLIHTCGQVDVAE
MMAR_3045|M.marinum_M               MLDYIRDAAEIYRQSFATIRAEADLSRFPADIARVVVRLIHTCGQVDVAE
MUL_2289|M.ulcerans_Agy99           MLDYIRDAAEIYRQSFATIRAEADLSRFPADIARVVVRLIHTCGQVDVAE
                                                                       :***********:. 

Mflv_3105|M.gilvum_PYR-GCK          HVAFTSDVTARAHAALAAGAPILCDSSMVAAGITRSRLPADNEVVSLVAD
Mvan_3430|M.vanbaalenii_PYR-1       HVAFTRDVTARTHAALTAGAPILCDSSMVAAGITRLRLPADNEVVSLVAD
MAB_2199c|M.abscessus_ATCC_199      EIAFTPGVVARTRAALDAGAPILCDSSMVAAGITRLRLPADNEVVSLVAD
TH_0439|M.thermoresistible__bu      HIAFTDDVVIRAHGALAGGAPILCDSSMVAAGITRSRLPADNEVVSLVAD
MSMEG_3872|M.smegmatis_MC2_155      HVAFTGDVVTRTHATLADGAPILCDSSMVAAGITRSRLPADNEVVSLVAD
Mb2091|M.bovis_AF2122/97            HVAYTDDVVARAGAALAAGAPVLCDSSMVAAGITTSRLPADNQIVSLVAD
Rv2065|M.tuberculosis_H37Rv         HVAYTDDVVARAGAALAAGAPVLCDSSMVAAGITTSRLPADNQIVSLVAD
MAV_2431|M.avium_104                HVAFTDDVVERVGTALRAGAPVLCDSSMVAAGITAARLPADNEVVSLVAD
MMAR_3045|M.marinum_M               HVAYTADVVTRAGTALRDGAPVLCDSSMVAAGITVARLPADNQVVSLVAD
MUL_2289|M.ulcerans_Agy99           HVAYTAGVVTRAGTALRDGAPVLCDSSMVAAGITVARLPADNQVVSLVAD
                                    .:*:* .*. *.  :*  ***:************  ******::******

Mflv_3105|M.gilvum_PYR-GCK          PRAPEMAAKLGSTRSAAAVDLWADRIPGAVFAIGNAPTALFRLLELVDDG
Mvan_3430|M.vanbaalenii_PYR-1       PRAPGLAAELGTTRSAAAVDLWSERIPGAVVAIGNAPTALFRLLELVDDG
MAB_2199c|M.abscessus_ATCC_199      PRAAELAQRTGTTRSAAAVDLWADRLPGSVAAIGNAPTALFRILELIDEG
TH_0439|M.thermoresistible__bu      ARAADLAARLGTTRSAAAVDLWAERLGGAVLAIGNAPTALFRLLELLDDG
MSMEG_3872|M.smegmatis_MC2_155      SRAPELAARMGTTRSAAAVDLWADRLGGAVLAIGNAPTALFRLLELLDEG
Mb2091|M.bovis_AF2122/97            PRATELAARRQTTRSAAGVELCAERLPGAVLAIGNAPTALFRLLELVDEG
Rv2065|M.tuberculosis_H37Rv         PRATELAARRQTTRSAAGVELCAERLPGAVLAIGNAPTALFRLLELVDEG
MAV_2431|M.avium_104                PRSAELAARRQTTRSAAGVELWADRLPGAVLAIGNAPTALFRLLELVDDG
MMAR_3045|M.marinum_M               PRAAGLAARRETTRSAAGVELWADRLAGAVLAIGNAPTALFRLLELIDEG
MUL_2289|M.ulcerans_Agy99           PRAAGLAARRETTRSAAGVELWADRLAGAVLAIGNAPTALFRLLELLDEG
                                    .*:. :* .  :*****.*:* ::*: *:* ***********:***:*:*

Mflv_3105|M.gilvum_PYR-GCK          VAPPAAVLGGPVGFVGSAQSKQELIDNPRGIPYLLVTGRRGGSAMAAAAV
Mvan_3430|M.vanbaalenii_PYR-1       LAPPASVLGGPVGFVGSAQSKQELIDNPRGMSYLVVTGRRGGSAMAAAAV
MAB_2199c|M.abscessus_ATCC_199      LAPPVSVLGGPVGFVGSAQSKQELIDRPRGMEYLLVRGRRGGSAMAAAAV
TH_0439|M.thermoresistible__bu      APVPAAVLGGPVGFVGSAQSKQELIDRPRGMSYLVVTGRRGGSAMAAAAV
MSMEG_3872|M.smegmatis_MC2_155      APTPAAVLGGPVGFVGSAQSKQELIERPRGMSYLVVTGRRGGSAMAAAAV
Mb2091|M.bovis_AF2122/97            APPPAAVLGGPVGFVGSAQAKEELIERPRGMSYLVVRGRRGGSAMAAAAV
Rv2065|M.tuberculosis_H37Rv         APPPAAVLGGPVGFVGSAQAKEELIERPRGMSYLVVRGRRGGSAMAAAAV
MAV_2431|M.avium_104                VGPPAGVLGGPVGFVGSAQSKQELVDNPRGMSYLVVRGRRGGSAMAAAAV
MMAR_3045|M.marinum_M               APAPAAVLGGPVGFVGSAQSKQELIDRPRGMSYLVVGGRRGGSAMAAAAV
MUL_2289|M.ulcerans_Agy99           APAPAAVLGGPVGFVGSAQSKQELIDRPRGMSYLVVGGRRGGSAMAAAAV
                                       *..*************:*:**::.***: **:* *************

Mflv_3105|M.gilvum_PYR-GCK          NSIAAEQE
Mvan_3430|M.vanbaalenii_PYR-1       NSIAAEEE
MAB_2199c|M.abscessus_ATCC_199      NAIASDKD
TH_0439|M.thermoresistible__bu      NAIASEKE
MSMEG_3872|M.smegmatis_MC2_155      NAIASERE
Mb2091|M.bovis_AF2122/97            NAIASDRE
Rv2065|M.tuberculosis_H37Rv         NAIASDRE
MAV_2431|M.avium_104                NAIASDRE
MMAR_3045|M.marinum_M               NAIANDSE
MUL_2289|M.ulcerans_Agy99           NAIANDSE
                                    *:** : :

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_0439	cobH	-	100% (209)	Probable precorrin-8X methylmutase CobH (aka precorrin isomerase)