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MPPPIGYCPAVGFGGRHERSDAELLAAHVAGDRYAFDQLFRRHHRQLHRLARLTSRTSEDADDALQDAML SAHRGAGSFRYDAAVSSWLHRIVVNACLDRLRRAKAHPTAPLEDVYPVADRTAQVETAIAVQRALMRLPV EQRAAVVAVDMQGYSIADTRPDAGRGRGHRQEPLRPGAGPPSAAAGLSQHRGEHPALTPLPVRRSIDPRA RRYPTSGYCHRA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3911 | sigM | - | 100% (222) | RNA polymerase sigma factor SigM |
| M. tuberculosis H37Rv | Rv3223c | sigH | 3e-10 | 29.61% (179) | RNA polymerase sigma factor RpoE |
| M. tuberculosis H37Rv | Rv1221 | sigE | 3e-10 | 32.00% (150) | RNA polymerase sigma factor SigE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3941 | sigMa | 4e-89 | 95.83% (168) | RNA polymerase sigma factor SigM |
| M. gilvum PYR-GCK | Mflv_0841 | - | 4e-50 | 67.97% (153) | Fis family transcriptional regulator |
| M. leprae Br4923 | MLBr_01076 | sigE | 5e-09 | 30.07% (153) | RNA polymerase sigma factor SigE |
| M. abscessus ATCC 19977 | MAB_4938 | - | 1e-53 | 72.54% (142) | alternative RNA polymerase sigma factor SigM |
| M. marinum M | MMAR_5475 | sigM | 3e-61 | 72.12% (165) | alternative RNA polymerase sigma factor SigM |
| M. avium 104 | MAV_5299 | - | 3e-69 | 80.62% (160) | RNA polymerase sigma factor SigM |
| M. smegmatis MC2 155 | MSMEG_6931 | - | 3e-50 | 62.42% (165) | RNA polymerase sigma-70 factor |
| M. thermoresistible (build 8) | TH_2414 | sigM | 3e-57 | 73.38% (154) | POSSIBLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGM |
| M. ulcerans Agy99 | MUL_5064 | sigM | 5e-59 | 69.70% (165) | RNA polymerase sigma factor SigM |
| M. vanbaalenii PYR-1 | Mvan_6065 | - | 3e-54 | 66.87% (163) | Fis family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3911|M.tuberculosis_H37Rv ------------------------------------MPPPIGYCPAVGFG
Mb3941|M.bovis_AF2122/97 ------------------------------------MPPPIGYCPAVGFG
MAV_5299|M.avium_104 ----------------------------------------------MGFG
MMAR_5475|M.marinum_M ----------------------------------------------MAFG
MUL_5064|M.ulcerans_Agy99 ----------------------------------------------MAFG
Mflv_0841|M.gilvum_PYR-GCK ----------------------------------------------MG--
Mvan_6065|M.vanbaalenii_PYR-1 ----------------------------------------------MG--
MSMEG_6931|M.smegmatis_MC2_155 ----------------------------------------------MGRG
TH_2414|M.thermoresistible__bu ----------------------------------------------VK--
MAB_4938|M.abscessus_ATCC_1997 ----------------------------------------------MVQG
MLBr_01076|M.leprae_Br4923 MGDGIGMEREGRWTGNTQCPLRVVPGDESPTLDGRASPEDLIITNLLSPT
:
Rv3911|M.tuberculosis_H37Rv --GRHER-------SDAELLAAHVAGDRY-------AFDQLFRRHHRQLH
Mb3941|M.bovis_AF2122/97 --GRHER-------SDAELLAAHVAGDRY-------AFDQLFRRHHRQLH
MAV_5299|M.avium_104 RNGNGDR-------SDAELLAAHVAGDRY-------AFGELFVRHQRHLH
MMAR_5475|M.marinum_M --GKRQRRDTARQRTDAELLAAFVAGEQL-------AFEELFRRHHRQLY
MUL_5064|M.ulcerans_Agy99 --GKRQRRNTARQRTDAELLAAFVAGEQL-------AFEELFRRHHRQLY
Mflv_0841|M.gilvum_PYR-GCK IFGGHPQRP-PGPRTDAELLAAHVAGDRY-------AFEELFHRHHRQLY
Mvan_6065|M.vanbaalenii_PYR-1 IFGGTHGRPEQQPRTDAELLAAHVAGDRY-------AFEELFHRHHRQLY
MSMEG_6931|M.smegmatis_MC2_155 EFAGA-----AHTRSDAELLAAHVAGDRY-------AFEELVLRHHRQLR
TH_2414|M.thermoresistible__bu SFGDD-----RRSRTDAELLAAHVDGDRY-------AFEELFHRHHRQLY
MAB_4938|M.abscessus_ATCC_1997 VLTTPQH-------SDAELLAAHVAGDPS-------AFEQLFRRHHRRLY
MLBr_01076|M.leprae_Br4923 IMSHPPPSRDDDWVEPFDALQGTAVFDATGDKATMPSWEELVRQHAARVY
: * . . : :: :*. :* ::
Rv3911|M.tuberculosis_H37Rv RLARLTSRTSEDADDALQDAMLSAHRGAGSFRYDAAVSSWLHRIVVNACL
Mb3941|M.bovis_AF2122/97 RLARLTSRTSEDADDALQDAMLSAHRGAGSFRYDAAVSSWLHRIVVNACL
MAV_5299|M.avium_104 RLARLTTRSPEDAEDALQDAMLSAHRGAGAFRHDAAVGSWLHRIVVNACL
MMAR_5475|M.marinum_M HLARLTSQTPEDAEDALQEAMISVHNCAGSFRQDAAVTSWLHRIVVNACL
MUL_5064|M.ulcerans_Agy99 HLARLTSQTPEDAEDALQEAMISVHNCAGSFRQDAAVTSWLHRIVVNACL
Mflv_0841|M.gilvum_PYR-GCK RLAHLTSRDPDDAADALQDAMLAAHRTARTFRQDCAVSSWLYRIVVNACL
Mvan_6065|M.vanbaalenii_PYR-1 RLAQLTSRDPDDAADALQDALLAAHRTARTFRHDSAVSSWLYRIVVNACL
MSMEG_6931|M.smegmatis_MC2_155 RLAYLTSNHLDDADDAVQEALLKAHRTAATFRFDCAVSSWLYRIVVNACL
TH_2414|M.thermoresistible__bu RLARLTSRHPEDAADALQEAMLSAHRSAPAFRYDSAVSSWLHRIVVNSCL
MAB_4938|M.abscessus_ATCC_1997 RLARATSRTPEDAADALQEAMLSAHRGAANFRNDAAVTSWLYRIVVNACL
MLBr_01076|M.leprae_Br4923 WLAYRLSGNQHDAEDLTQETFIRVFRSVQNYQPGTFEG-WLHRITTNLFL
** : .** * *:::: ... . :: . **:**..* *
Rv3911|M.tuberculosis_H37Rv DRLRRAKAH-------PTAPLED-VYPVADRTAQVETAIAVQRALMRLPV
Mb3941|M.bovis_AF2122/97 DRLRRAKAH-------PTAPLED-VYPVADRTAQVETAIAVQRALMRLPV
MAV_5299|M.avium_104 DRLRRTKAH-------PTVPLED-IYPVADRTAQVETTLAVQRALMRLPV
MMAR_5475|M.marinum_M DRLRRAKSR-------PTVPLED-VYPVPDATTRVETAILVRRALMRLPV
MUL_5064|M.ulcerans_Agy99 ERLRRAESR-------PTVPLED-VYPVPDATTRVETAILVRRALMRLPV
Mflv_0841|M.gilvum_PYR-GCK DRLRRNKTR-------AWDVLDDESAGAFDPTGHVDTAIVVERALLCLPV
Mvan_6065|M.vanbaalenii_PYR-1 DRLRRNRSR-------ACEELDDQAGPVVDPTGRVDTAIVVERALMRLPL
MSMEG_6931|M.smegmatis_MC2_155 DRLRRTRTQPSATHYVELGHVNHLRDPAADPAPRVTTAITVERALLQLPV
TH_2414|M.thermoresistible__bu DRLRRNKSR-------PTAALRDDVAATGDPTAAVDTAIVVQRALMTLPV
MAB_4938|M.abscessus_ATCC_1997 DRMRRNKAH-------IPIELEEDVYTLEDPSTNVDTSIVIQKALLRLPA
MLBr_01076|M.leprae_Br4923 DMVRRRARIRMDALPDDYDRVPADEPNPEQIYHDSRLGPDLQAALDSLPP
: :** : : :. ** **
Rv3911|M.tuberculosis_H37Rv EQRAAVVAVDMQGYSIADTRPDAGRGRGHRQEPLRPGAGPPSAAAGLSQH
Mb3941|M.bovis_AF2122/97 EQRAAVVAVDMQGYSIADTSRMLG------------------VAEGTVKS
MAV_5299|M.avium_104 EQRAAIVAVDMQGYSVADTARLLG------------------VAEGTVKS
MMAR_5475|M.marinum_M EQRAAVVAVDMQGYSIADTALLLG------------------VAQGTVKS
MUL_5064|M.ulcerans_Agy99 EQRAAVVAVDMQRYSIPDTALLLG------------------VAQGTVKS
Mflv_0841|M.gilvum_PYR-GCK EQRAAVVAVDMQGFSVAETARMLG------------------VPEGTVKS
Mvan_6065|M.vanbaalenii_PYR-1 EQRAAVVAVDMQGYSIAETARMLG------------------VAEGTVKS
MSMEG_6931|M.smegmatis_MC2_155 DQRAAVVAVDMQGYSVAETARLLG------------------VAEGTIKS
TH_2414|M.thermoresistible__bu EQRAAVVAVDMQGYSVAETARLLG------------------VAEGTVKS
MAB_4938|M.abscessus_ATCC_1997 EQRAAVIAVDMQGYSVADAAELLG------------------VPEGTVKS
MLBr_01076|M.leprae_Br4923 EFRAAVVLCDIEGLSYEEIGATLG------------------VKLGTVRS
: ***:: *:: * : * . * :
Rv3911|M.tuberculosis_H37Rv RGEHPALTPLPVRRSIDPRARRYPTSGYCHRA----------
Mb3941|M.bovis_AF2122/97 RCAR--------ARARLARLLGYLNTGVNIRR----------
MAV_5299|M.avium_104 RCAR--------ARVRLAELLGYLDAGAHAAAEGAAGQA---
MMAR_5475|M.marinum_M RCAR--------GRARLARLLGYLDADINAVDMN--------
MUL_5064|M.ulcerans_Agy99 RCAR--------GRARLARLLSYLDADINAVDMN--------
Mflv_0841|M.gilvum_PYR-GCK RCSR--------ARTKLAAALDCFAAVD--------------
Mvan_6065|M.vanbaalenii_PYR-1 RCSR--------ARTKLAASLDCFTATAE-------------
MSMEG_6931|M.smegmatis_MC2_155 RCAR--------ARAKLARTLQYFDGDEPQPATSAHRGAAHP
TH_2414|M.thermoresistible__bu RCSR--------ARAKLAGVLRHLDSRSPVGARSRQ------
MAB_4938|M.abscessus_ATCC_1997 RCAR--------ARARLAVALHYLDKAGSVEPETIDY-----
MLBr_01076|M.leprae_Br4923 RIHR--------GRQALRDYLLTAHPRDGATTDATHVKSA--
* : *