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IQVCSQCGTGWNVRERQRVWCPRCRGMLLAPLADMPAEARWRTPARPQVPTASDTRRTPPRLPPGFRWIA VRPGAAPPPRHGPRLRGPTPRYAGIPRWGLTDHVDQAPVPASAKAGPSPAAVRTTLLVSLLVFSIAVVVF VVRYVLLVINRNTLLNSVVASASVWLGVLVSLAAIAAAGTTIVLLVRWLVARRAAAFMHQGLPERRSARE LWAGCLLPMVNLLWAPLYVIELALVEDRYTRLRRPIVVWWIVWIVSNAISMFAFATSWVTDAQGIANNTT MMVLAYLCAAAAVAAAARVFEGFEQKPVERPAHRWVVVNTDGRSAPASSVAVELDGQEPAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3843c | - | - | 100% (342) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3873c | - | 0.0 | 99.42% (342) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_1139 | - | 2e-98 | 52.16% (347) | hypothetical protein Mflv_1139 |
| M. leprae Br4923 | MLBr_00073 | - | 1e-119 | 63.32% (349) | hypothetical protein MLBr_00073 |
| M. abscessus ATCC 19977 | MAB_0122 | - | 1e-61 | 38.06% (381) | hypothetical protein MAB_0122 |
| M. marinum M | MMAR_5395 | - | 1e-124 | 62.29% (358) | hypothetical protein MMAR_5395 |
| M. avium 104 | MAV_0184 | - | 4e-93 | 61.54% (273) | hypothetical protein MAV_0184 |
| M. smegmatis MC2 155 | MSMEG_6424 | - | 2e-78 | 46.15% (338) | transmembrane protein |
| M. thermoresistible (build 8) | TH_4282 | - | 1e-59 | 47.06% (255) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_5016 | - | 1e-122 | 61.73% (358) | hypothetical protein MUL_5016 |
| M. vanbaalenii PYR-1 | Mvan_5668 | - | 4e-98 | 53.20% (344) | hypothetical protein Mvan_5668 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3843c|M.tuberculosis_H37Rv MIQVCSQCGTGWNVRERQRVWCPRCRGMLLAP------------------
Mb3873c|M.bovis_AF2122/97 MIQVCSQCGTRWNVRERQRVWCPRCRGMLLAP------------------
MLBr_00073|M.leprae_Br4923 MIQVCSQCGTRWNVRERRREWCLRCRGALIAP------------------
MAV_0184|M.avium_104 --------------------------------------------------
MMAR_5395|M.marinum_M MIQVCSQCGTRWNVRERQRVWCPRCRGALMAP------------------
MUL_5016|M.ulcerans_Agy99 MIQVCSQCGTRWNVRERQRVWCPRCRGALMAP------------------
Mflv_1139|M.gilvum_PYR-GCK MIQVCSQCGTRWNVRDRQRVWCPRCRGTLLAP------------------
Mvan_5668|M.vanbaalenii_PYR-1 MIQVCSQCGTRWNVRDRQRVWCPRCRGTLLAP------------------
TH_4282|M.thermoresistible__bu --------------------------------------------------
MSMEG_6424|M.smegmatis_MC2_155 MIQVCSQCGTRWNVRERQRSWCPRCGGGLLAP------------------
MAB_0122|M.abscessus_ATCC_1997 MIQVCSRCGTQWNVREQRRYWCPRCRGTLLEPGMTAPPRPAASMSRPPVG
Rv3843c|M.tuberculosis_H37Rv -LADMPAEARWRTPARPQVPTASDTRRTPPRLPPGFRWIAVRPGAAPPPR
Mb3873c|M.bovis_AF2122/97 -LADMPAEARWRTPARPQVPTASDTRRTPPRLPPGFRWIAVRPGAAPPPR
MLBr_00073|M.leprae_Br4923 -QAEMPTAVKQWSSHVGLPAGIVPEALGWQRTPPGFRWIAVRPGAAPPNR
MAV_0184|M.avium_104 ----------------------------------------MRPGAAPPPR
MMAR_5395|M.marinum_M -LTGAAAADPQSRTSVGPQRVASTARRAAPRLPPGFRWIAVRPGAAPPHR
MUL_5016|M.ulcerans_Agy99 -LTGAAAADPQSRTSVGPQRVASTARRAAPRLPPGFRWIAVRPGAAPPHR
Mflv_1139|M.gilvum_PYR-GCK -SGPAPAQG-----WDQRPA---------ARPPAGYRWVAVRPGAPPRPR
Mvan_5668|M.vanbaalenii_PYR-1 -SGHAAGHG-----WDPRQASPQDAPRQGARLPSGYRWVAVRPGAPPRPP
TH_4282|M.thermoresistible__bu --------------------------------------------------
MSMEG_6424|M.smegmatis_MC2_155 -SAPE-------SQWASPPRQPQQPQRPPARLAPGYRWIAVRPGAPPPSR
MAB_0122|M.abscessus_ATCC_1997 APAPAGKYWVPPTQQGPVATPAGRPQARPTRLPAGYRWIAVRPGSPPAPA
Rv3843c|M.tuberculosis_H37Rv HGPRLRGPTPRYAGIPRWGLTDHVD-QAP--VPASAKAGPSPAAVRTTLL
Mb3873c|M.bovis_AF2122/97 HGPRLRGPTPHYAGIPRWGLTDHVD-QAP--VPASAKAGPSPAAVRTTLL
MLBr_00073|M.leprae_Br4923 RRQRHHVPTPRYAVMPRWGLADRVD-QDSTWIQAPLKPGPSSAKVRTTLF
MAV_0184|M.avium_104 RGRRPLGPTPRYAVIPRWGLADRVE-PPPAVAAASAHPGPPAQLVRSTSF
MMAR_5395|M.marinum_M PRRRAYGPTPRYTVMPRWGLGDRVAQPGPSPVPVATKTGPAAATVRTLLF
MUL_5016|M.ulcerans_Agy99 PRRRAYGPTPRYTVMPRWGLGDRVAQPGPLPVPVATKTGPAAATVRTLLF
Mflv_1139|M.gilvum_PYR-GCK RVRRELGPTPRYQSIPRWGLVEHFD---APAEQTAERTGPSANAVRALLL
Mvan_5668|M.vanbaalenii_PYR-1 RRRRDLGPTPRYLSIPRWGLVERFD---VPVEDAAQRKGPSVNAVQMTLV
TH_4282|M.thermoresistible__bu --------------------VEHFD---TAPQDAGPEPGASAALVRGVLI
MSMEG_6424|M.smegmatis_MC2_155 PRRRPLGPTPRYLTVPRWGLHQDFA--VAEERQQAQRTGPAAHTVRLVIV
MAB_0122|M.abscessus_ATCC_1997 RRRRPLGPTPRYAYIPRWGLVDHIEPTGSSRQGIAGGAVPS-RILDRLLL
: . .. : .
Rv3843c|M.tuberculosis_H37Rv VSLLVFSIAVVVFVVRYVLLVINRNTLLNSVVASASVWLGVLVSLAAIAA
Mb3873c|M.bovis_AF2122/97 VSLLVFSIAVVVFVVRYVLLVINRNTLLNSVVASASVWLGVLVSLAAIAA
MLBr_00073|M.leprae_Br4923 VAVLVFTLAALVYVVRYVLLVINRNTLLNFGVAAIADWLGVIASLAAIAA
MAV_0184|M.avium_104 VGVLVLGIAALVYVVRYLLLVINRDTLLYSWVAIGADWLGVLASVGAVGA
MMAR_5395|M.marinum_M ATMLVLGAAAFVYAVRYVLLIINRDILLNSVLAGIAVWVGVAVSFAALAA
MUL_5016|M.ulcerans_Agy99 ATMLVLGAAAFVYAVRYVLLIINRDILLNSVLAGIAVWVGVAVSFAALAA
Mflv_1139|M.gilvum_PYR-GCK VTMAALGAAAFVHVVRYILLIVNRTVLLPPWLAAAATWGGVAVSVVAVFT
Mvan_5668|M.vanbaalenii_PYR-1 ATMAVLGAAAFVHVVRYVLLIVNRSVLLNPWIAGAATWGGVAVSVVAVFL
TH_4282|M.thermoresistible__bu LTMVILGAAAFAHIVRYVLLLINRSTLLHPWVAAVATWLPVALSVAAMFA
MSMEG_6424|M.smegmatis_MC2_155 LAMIALAGAAFAHIVRYILLLVNRTVLLHPVIAWGGVLLGMLASLLVLAI
MAB_0122|M.abscessus_ATCC_1997 ATIITLAITSCTHFLRYALMVYNRGALIPRFVASASNGLVLISVALAFAV
: : : .. :** *:: ** *: :* . : ..
Rv3843c|M.tuberculosis_H37Rv AGTTIVLLVRWLVARRAAAFMHQGLPERRSARELWAGCLLPMVNLLWAPL
Mb3873c|M.bovis_AF2122/97 AGTTIVLLVRWLVARRAAAFMHQGLPERRSARELWAGCLLPMVNLLWAPL
MLBr_00073|M.leprae_Br4923 TLACVMALSRWLIARRAAAYAHHAVPEQRSSWELRAGCLLPLVNLLWAPV
MAV_0184|M.avium_104 VIASGVALIRWMIARRAAVFAHHGLPDPRSARALGAGCVVPLANLLWAPV
MMAR_5395|M.marinum_M MGVCFVVLIKWLVARRAAAFAYYGLPEHRSTLQLWAGCLTPLANLLWAPV
MUL_5016|M.ulcerans_Agy99 MGVCFVVLIKWLVARRAVAFAYYGLPEHRSTLQLWAGCLTPLANLLWAPV
Mflv_1139|M.gilvum_PYR-GCK VVASALMLTNWLIARRAAAYAHRGHQDPRSAASLRLGCLVPVANLLWAPV
Mvan_5668|M.vanbaalenii_PYR-1 TVASLVVLTNWLIARRSAAFAHQGHRDPRSAWVLRLGCLTPFVNLFWAPV
TH_4282|M.thermoresistible__bu VVTTILVLTNWLIARRAATYRRLGTSDPRPVWMLWTGCVLPVVNLIVAPV
MSMEG_6424|M.smegmatis_MC2_155 MTITVVMLISWLVARRREAYSQRGQEDPRSPLELWICALAPVVNLFMAPV
MAB_0122|M.abscessus_ATCC_1997 MAATAWFLTDWMIARRAETYRDLGFDDPRSPWEIRVLCLLPIANIVGIPL
* *::*** .: . : *. : .: *..*:. *:
Rv3843c|M.tuberculosis_H37Rv YVIELALVEDRYTRLRRPIVVWWIVWIVSNAISMFAFATS-----WVTDA
Mb3873c|M.bovis_AF2122/97 YVIELALVEDRYTRLRRPIVVWWIVWIVSNAISMFAFATS-----WVTDA
MLBr_00073|M.leprae_Br4923 YVIELALMENHYTQLQKPIFMWWIVWVFSYVISVVAVVTS-----WAKDA
MAV_0184|M.avium_104 FVIELALLEEHYHRLKGPILQWWITWVCSYAVSVSAIATS-----FVTDA
MMAR_5395|M.marinum_M YLIELAVVEDTYQRLKKPILVWWIAWVVSTATSLFAIATS-----FSSDA
MUL_5016|M.ulcerans_Agy99 YLIELAVVEDTYQRLKKPILVWWIAWVVSTATSLFAIATS-----FSSDA
Mflv_1139|M.gilvum_PYR-GCK YVIELADTEARLRWLHRSILLWWVVWVVSTAVSIFSIATS-----FTTDP
Mvan_5668|M.vanbaalenii_PYR-1 YVMELADAEGRQRWLHRPIVVWWLFWVASTTVTTFAFATS-----FTADA
TH_4282|M.thermoresistible__bu FIFELAKAEDRLSWLRRPVYVFWAAWLVSHVISGCAFFTS-----FARDA
MSMEG_6424|M.smegmatis_MC2_155 FVLELARADNRMTLLRRPIAVWWIVWVLSAIVATWSIVSTVYVTFFNNTP
MAB_0122|M.abscessus_ATCC_1997 LLLELAKIENRWYRQYRNIMWWTVLWAATWLLALVTWVVR-----DSVTV
::*** : : : * : : :
Rv3843c|M.tuberculosis_H37Rv QGIANNTTMMVLAYLCAAAAVAAAARVFEGFEQKPVE-RPAHRWVVVNTD
Mb3873c|M.bovis_AF2122/97 QGIANNTTMMVLAYLCAAAAVAAAARVFEGFEQKPVE-RPAHRWVVVNTD
MLBr_00073|M.leprae_Br4923 QGIANNTVAMVFAYLFAAAAVAAVARVFEGFECKSIK-RPVHRWVVVHLG
MAV_0184|M.avium_104 QGIANNTILMVFGYLFAAATLAAATRIFEGFQRKPVA-RPAHRWVMVPDD
MMAR_5395|M.marinum_M QGIANNTVMVVVAYALAAAAVGTVSRVFEGFERKPVQ-RPAHRWLVMGQD
MUL_5016|M.ulcerans_Agy99 QGIANNTVMVVVAYALAAAAVGTVSRVFEGFECKPVQ-RPAHRWLVMGQD
Mflv_1139|M.gilvum_PYR-GCK QGIADNTVVTIVAYLFGLAALVLVQRVFDGFEQQPVS-RPSHRWVVV---
Mvan_5668|M.vanbaalenii_PYR-1 QGIADNTVTTIVAYLFAAAALLSALRVFLGFERQPVQ-RPSRRWVTV---
TH_4282|M.thermoresistible__bu QGIADNTVITVVAYLAALAVVVLVARVHDSFDRTPVE-RPARRWVVVPDQ
MSMEG_6424|M.smegmatis_MC2_155 QNIADNTVTVIIGYLLGLTTLLLTYRVFQGFEATEAQGRSVRRWVVVAEG
MAB_0122|M.abscessus_ATCC_1997 QGIADNALFTAIDYAVAAVAAWRLRRVYEGFTAPEGH-HRAVRWLAVESP
*.**:*: . * . .. *:. .* : **: :
Rv3843c|M.tuberculosis_H37Rv G-------------------------------------------RSAPAS
Mb3873c|M.bovis_AF2122/97 G-------------------------------------------RSAPAS
MLBr_00073|M.leprae_Br4923 GS------------------------------------------VVHPSP
MAV_0184|M.avium_104 G-------------------------------------------PPPPAP
MMAR_5395|M.marinum_M DQPGRS-------------------------------ATDEDDRVDAAPD
MUL_5016|M.ulcerans_Agy99 DQPGRS-------------------------------ATDEDDRVDAAPD
Mflv_1139|M.gilvum_PYR-GCK -------------------------------------GAPQDGEVDDTQP
Mvan_5668|M.vanbaalenii_PYR-1 -------------------------------------RVD-AGESDDAEP
TH_4282|M.thermoresistible__bu TAE-PG-------------------------------RPGGSEEHADGSS
MSMEG_6424|M.smegmatis_MC2_155 AKPPAGPGGPHGSGPAGRSTEEADESTDTADTPAEGDTEPADEQPQRPES
MAB_0122|M.abscessus_ATCC_1997 QGPVPLDAD-----------------------------RPDVPPTRDANS
Rv3843c|M.tuberculosis_H37Rv SVAVELDGQEPAA----------
Mb3873c|M.bovis_AF2122/97 SVAVELDGQEPAA----------
MLBr_00073|M.leprae_Br4923 GS-VELEGQEPAA----------
MAV_0184|M.avium_104 GAPVEFKGQEPAA----------
MMAR_5395|M.marinum_M ADAVELEGQEPAA----------
MUL_5016|M.ulcerans_Agy99 ADAFELEGQEPAA----------
Mflv_1139|M.gilvum_PYR-GCK ARAVETDGQNPAA----------
Mvan_5668|M.vanbaalenii_PYR-1 ARAVESNGENPAA----------
TH_4282|M.thermoresistible__bu APPVEAGGQNPAA----------
MSMEG_6424|M.smegmatis_MC2_155 SVPVEPAGQNPAA----------
MAB_0122|M.abscessus_ATCC_1997 GAAVEPVGTEPAALDRDRVVGAW
. .* * :***