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VTRTVAAPPVCVLGLGLIGGSIMRAAAAAGREVFGYNRSVEGAHGARSDGFDAITDLNQTLTRAAATEAL IVLAVPMPALPGMLAHIRKSAPGCPLTDVTSVKCAVLDEVTAAGLQARYVGGHPMTGTAHSGWTAGHGGL FNRAPWVVSVDDHVDPTVWSMVMTLALDCGAMVVPAKSDEHDAAAAAVSHLPHLLAEALAVTAAEVPLAF ALAAGSFRDATRVAATAPDLVRAMCEANTGQLAPAADRIIDLLSRARDSLQSHGSIADLADAGHAARTRY DSFPRSDIVTVVIGADKWREQLAAAGRAGGVITSALPSLDSPQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3754 | tyrA | - | 100% (301) | prephenate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3780 | tyrA | 1e-171 | 100.00% (301) | prephenate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1212 | - | 1e-117 | 70.85% (295) | prephenate dehydrogenase |
| M. leprae Br4923 | MLBr_02472 | - | 1e-137 | 80.00% (300) | prephenate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0266c | - | 1e-94 | 61.72% (290) | prephenate dehydrogenase |
| M. marinum M | MMAR_5297 | tyrA | 1e-142 | 84.00% (300) | prephenate dehydrogenase TyrA |
| M. avium 104 | MAV_0321 | - | 1e-138 | 79.40% (301) | prephenate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6330 | - | 1e-113 | 69.57% (299) | prephenate dehydrogenase |
| M. thermoresistible (build 8) | TH_1655 | tyrA | 1e-119 | 71.24% (299) | PREPHENATE DEHYDROGENASE TYRA (PDH) (HYDROXYPHENYLPYRUVATE |
| M. ulcerans Agy99 | MUL_4372 | tyrA | 1e-141 | 83.67% (300) | prephenate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5596 | - | 1e-119 | 72.58% (299) | prephenate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3754|M.tuberculosis_H37Rv ---------------------------MRAAAAAGREVFGYNRSVEGAHG
Mb3780|M.bovis_AF2122/97 ---------------------------MRAAAAAGREVFGYNRSVEGAHG
MMAR_5297|M.marinum_M ---------MQTTPVCVLGLGLIGGSIMRATAAADRVVFGYNRSVEGANG
MUL_4372|M.ulcerans_Agy99 --------------MCVLGLGLIGGSIMRATAAADRVVFGYNRSVEGANG
MLBr_02472|M.leprae_Br4923 MSILDGGWDCVGRPVCVLGLGLIGGSIMRATAEAGREVFGYNRSVKGAQS
MAV_0321|M.avium_104 --------------MCVLGLGLVGGSIMRAATAAGREVFGYNRSIEGAQA
Mflv_1212|M.gilvum_PYR-GCK --------------MCVIGLGLIGGSLMRAAKAAGREVFGYNRSLDGVEA
Mvan_5596|M.vanbaalenii_PYR-1 ---MCQPRHVTKTPVCVIGLGLIGGSLMRAAKAAGREVFGYNRSVEGVDA
MSMEG_6330|M.smegmatis_MC2_155 --------------MCVLGLGLIGGSVMRAAAAAGREVFGYNRSVEAVQA
TH_1655|M.thermoresistible__bu ---------VTKVPICVLGLGLIGGSIMRAARAAGREVFGYNRSIDGVTA
MAB_0266c|M.abscessus_ATCC_199 --MNAAEHDHQRPPICVLGLGLIGGSLMRAATAAGRNVWGYNRSAEGVDA
***: *.* *:***** ... .
Rv3754|M.tuberculosis_H37Rv ARSDGFDAITDLNQTLTRAAATEALIVLAVPMPALPGMLAHIRKSAPGCP
Mb3780|M.bovis_AF2122/97 ARSDGFDAITDLNQTLTRAAATEALIVLAVPMPALPGMLAHIRKSAPGCP
MMAR_5297|M.marinum_M AQSDGFEATTDLAETLARAADTNALIVLAVPMPALPSMLTHIRELAPSCP
MUL_4372|M.ulcerans_Agy99 AQSDGFEATTDLAETLARAADTTALIVLAVPMPALPSMLTHIRELAPNCP
MLBr_02472|M.leprae_Br4923 ARSDGFDATTKLADALVRAADTHALIVLAVPMPALPAMLAHIRELAPNCP
MAV_0321|M.avium_104 ATADGFDADTDLTATLSRAADSDALIVLAVPMPALPSMLAHVKETAPQCP
Mflv_1212|M.gilvum_PYR-GCK ARADGFDATADLDEALSRASASGALIVLAVPMPALPLMLRHVRAVAPACA
Mvan_5596|M.vanbaalenii_PYR-1 ARLAGFDASTNLDETLARAAAVDALIVLAVPMPALPLMLRHVRESAADCA
MSMEG_6330|M.smegmatis_MC2_155 ATFDGFDATANLDKALARAAADDALIVLAVPMPALGLMLGHIRAAAANCA
TH_1655|M.thermoresistible__bu ARAEGFDATEHLDEALARAAEQRALIVLAVPMFAVPMLLERIAQEAADCP
MAB_0266c|M.abscessus_ATCC_199 ARTAGYDATADLDLALRRARNAQALIVLAVPVPALSPLLNRIAELAPECP
* *::* .* :* ** ********: *: :* :: *. *.
Rv3754|M.tuberculosis_H37Rv LTDVTSVKCAVLDEVTAAGLQARYVGGHPMTGTAHSGWTAGHGGLFNRAP
Mb3780|M.bovis_AF2122/97 LTDVTSVKCAVLDEVTAAGLQARYVGGHPMTGTAHSGWTAGHGGLFNRAP
MMAR_5297|M.marinum_M LTDVTSVKTAVLEEVTEAGLRERFVGGHPMTGTAHSGWGAGHGALFTRAP
MUL_4372|M.ulcerans_Agy99 LTDVTSVKTAVLEEVTEAGLRERFVGGHPMTGTAHSGWGAGHGALFTRAP
MLBr_02472|M.leprae_Br4923 LTDVTSVKTAVLDAVVSVGLQARFVGGHPMTGTAQSGWGAGHGGLFNRTS
MAV_0321|M.avium_104 LTDVTSVKKAVLDEVVAAGLRDRFVGGHPMAGTAHSGWTAGHAGLFTGAP
Mflv_1212|M.gilvum_PYR-GCK LTDVTSVKGAVLDAVAEAGLLDRFVGGHPMTGTAYSGWSAGDERLFVDTP
Mvan_5596|M.vanbaalenii_PYR-1 LTDVTSVKGAVHEEVAKAGLLARFVGGHPMTGTAHSGWAAGDARLFVGAP
MSMEG_6330|M.smegmatis_MC2_155 LTDVISVKGAVLREVEMYGLLERFVGGHPMAGTAHSGWAAGSVDLFVGAP
TH_1655|M.thermoresistible__bu LTDVVSVKGAVLEEVRAHGLLARFVGGHPMTGTAHSGWSAGDADLFAGTP
MAB_0266c|M.abscessus_ATCC_199 LTDVTSVKSAVLQTVSEHGLAQRFVGGHPMAGTTESGWSAGDAELFRDAT
**** *** ** * ** *:******:**: *** ** ** :.
Rv3754|M.tuberculosis_H37Rv WVVSVDDHVDPTVWSMVMTLALDCGAMVVPAKSDEHDAAAAAVSHLPHLL
Mb3780|M.bovis_AF2122/97 WVVSVDDHVDPTVWSMVMTLALDCGAMVVPAKSDEHDAAAAAVSHLPHLL
MMAR_5297|M.marinum_M WVVSVDDHVDPVVWSMVMQLALDCGAVVVPAKSDEHDAAAAAISHLPHLL
MUL_4372|M.ulcerans_Agy99 WVVSVDDHVDPVVWSMVMQLALDCGAVVVPAKSDEHDAAAAAISHLPHLL
MLBr_02472|M.leprae_Br4923 WVLSVDDHVDPAVWSMVMTLALDCGALVLPAKSDEHDAAAAAISHMPHLL
MAV_0321|M.avium_104 WVVSVDDHVDPVVWAMVMTLALDCGAVVVPARSDEHDAAAAAISHLPHLL
Mflv_1212|M.gilvum_PYR-GCK WVLSVDDHVDPDVWARVMRLALDCGAFVVPARSDEHDTAAATISHLPHLL
Mvan_5596|M.vanbaalenii_PYR-1 WVLSVDDHVDPGVWATVMHLALDCGSFVVPARSDEHDAAAATISHLPHLL
MSMEG_6330|M.smegmatis_MC2_155 WVVSVDDHVDAGVWTQVAQLALDCHAVVVPARSDEHDAAAAAISHLPHLF
TH_1655|M.thermoresistible__bu WVVSVDDHVDPAIWAMVMELALDCRAVVVPARSDEHDAAAASVSHLPHLL
MAB_0266c|M.abscessus_ATCC_199 WVVSVDDDVDPHVFAQVTQLALDCGSVVVPARSDEHDAAAAAISHLPHLL
**:****.**. ::: * ***** :.*:**:*****:***::**:***:
Rv3754|M.tuberculosis_H37Rv AEALAVTAAEVPLAFALAAGSFRDATRVAATAPDLVRAMCEANTGQLAPA
Mb3780|M.bovis_AF2122/97 AEALAVTAAEVPLAFALAAGSFRDATRVAATAPDLVRAMCEANTGQLAPA
MMAR_5297|M.marinum_M AEALAVTAAEVPLAFALAAGSFRDATRVAGTAPDLVRAMCEANTGQLVPA
MUL_4372|M.ulcerans_Agy99 AEALAVTAAEVPLAFALAAGSFRDATRVAGTAPDLVRAMCEANTGQLVPA
MLBr_02472|M.leprae_Br4923 AEALAVAAAEVPLAFAVAAGSFRDATRVAGTAPDLVRAMCEGNSGQLLSS
MAV_0321|M.avium_104 AEALAVVAGDVPLAFALAAGSFRDGTRVAATAPDLVRAMCEGNSDQLVPT
Mflv_1212|M.gilvum_PYR-GCK AEALAATAGEVPLAFALAAGSFRDGTRVAGTAPDLVRAMCEANAAQVVPV
Mvan_5596|M.vanbaalenii_PYR-1 AEALAATAGEVPLAFALAAGSFRDGTRVAATAPDLVRAMCEANATHLLPV
MSMEG_6330|M.smegmatis_MC2_155 AETMAEIAGEVPLAYALAAGSFRDGTRVAGSAPDLVRAMCEANAAQLLPA
TH_1655|M.thermoresistible__bu AEALAITAGEVPLAFSLAAGSFRDGTRVAATAPDLVRAMCENNADQLLPA
MAB_0266c|M.abscessus_ATCC_199 AEALAVTADGVPLAYSLAAGSFRDGTRVAATDPSLVRAMCESNPHGVLPA
**::* * ****:::*******.****.: *.******* *. : .
Rv3754|M.tuberculosis_H37Rv ADRIIDLLSRARDSLQSHGSIADLADAGHAARTRYDSFPRSDIVTVVIGA
Mb3780|M.bovis_AF2122/97 ADRIIDLLSRARDSLQSHGSIADLADAGHAARTRYDSFPRSDIVTVVIGA
MMAR_5297|M.marinum_M ADRIIELLNRARDSLACNGSVADLVDAGNAARTRYESFPRSDISTVTIGE
MUL_4372|M.ulcerans_Agy99 ADRIIELLNRARDSLACNGSVADLVDAGNAARTRYESFPPSDISTVTIGE
MLBr_02472|M.leprae_Br4923 VDRVIELLCRARDSLACNNSVAELVEAGHAARARYDSFPRSDIVTVIIGA
MAV_0321|M.avium_104 ADHVIELLRRARDSLAHHKSVADLIEAGHAARTRYDSFPRTDIFHVVIGA
Mflv_1212|M.gilvum_PYR-GCK LDQALRLLTDARNRLAQHQPVADLVETGHAARIRYDSFSRPQIVAVTIGS
Mvan_5596|M.vanbaalenii_PYR-1 LDHALRLLIDARNQLAQHQPVSELVEGGHAARIRYDSFSRPQIVTTVIGA
MSMEG_6330|M.smegmatis_MC2_155 LDRGIELLTRARAALADTGSVAELVESGHAARMRYDSFARPDIIATVVGD
TH_1655|M.thermoresistible__bu LDRTLELLTAAREALAHNGSVAELVEAGHAARMRYDSFGRTDIMAVVIGE
MAB_0266c|M.abscessus_ATCC_199 LEEAMALLAATWNTLNAENSVELLVEAGHAARQRYEAHERFDISGISRHD
:. : ** : * .: * : *:*** **::. :*
Rv3754|M.tuberculosis_H37Rv DKWREQLAAAGRAGGVITSALPSLDSPQ
Mb3780|M.bovis_AF2122/97 DKWREQLAAAGRAGGVITSALPSLDSPQ
MMAR_5297|M.marinum_M PRWRERLAAAGRAGGVIKSALPSLDSPG
MUL_4372|M.ulcerans_Agy99 PRWRERLAAAGRAGGVIKSALPSLDSPG
MLBr_02472|M.leprae_Br4923 ENWREDLAAAGRAGGVIRSALPSLGSP-
MAV_0321|M.avium_104 ENWRQELAAAGRAGGVIRSALPTLDSPR
Mflv_1212|M.gilvum_PYR-GCK EGWRDELAAAGRAGGVIRSALPVRGSRG
Mvan_5596|M.vanbaalenii_PYR-1 EEWRDELAAAGRAGGVIRSALPVRDSRG
MSMEG_6330|M.smegmatis_MC2_155 ENWRDELAAAGRAGGVIRSALPVLGSRG
TH_1655|M.thermoresistible__bu EGWREELAAAGRAGGVIRSALPVRDS--
MAB_0266c|M.abscessus_ATCC_199 TDWREQLADAGRAGGVLRRVP-------
**: ** *******: .