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SFDSLSPQELAALHARHQQDYAALQGMKLALDLTRGKPSAEQLDLSNQLLSLPGDDYRDPEGTDTRNYGG QHGLPGLRAIFAELLGIAVPNLIAGNNSSLELMHDIVAFSMLYGGVDSPRPWIQEQDGIKFLCPVPGYDR HFAITETMGIEMIPIPMLQDGPDVDLIEELVAVDPAIKGMWTVPVFGNPSGVTYSWETVRRLVQMRTAAP DFRLFWDNAYAVHTLTLDFPRQVDVLGLAAKAGNPNRPYVFASTSKITFAGGGVSFFGGSLGNIAWYLQY AGKKSIGPDKVNQLRHLRFFGDADGVRLHMLRHQQILAPKFALVAEVLDQRLSESKIASWTEPKGGYFIS LDVLPGTARRTVALAKDVGIAVTEAGASFPYRKDPDDKNIRIAPSFPSVPDLRNAVDGLATCALLAATET LLNQGLASSAPNVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3722c | - | - | 100% (435) | hypothetical protein Rv3722c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3749c | - | 0.0 | 100.00% (435) | hypothetical protein Mb3749c |
| M. gilvum PYR-GCK | Mflv_1280 | - | 0.0 | 75.59% (426) | GntR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02336 | - | 0.0 | 87.50% (424) | hypothetical protein MLBr_02336 |
| M. abscessus ATCC 19977 | MAB_0305 | - | 0.0 | 75.64% (427) | putative aminotransferase |
| M. marinum M | MMAR_5241 | - | 0.0 | 89.39% (424) | transcriptional regulator |
| M. avium 104 | MAV_0381 | - | 0.0 | 87.00% (423) | aspartate transaminase |
| M. smegmatis MC2 155 | MSMEG_6286 | - | 0.0 | 74.41% (426) | aspartate transaminase |
| M. thermoresistible (build 8) | TH_1300 | - | 0.0 | 75.94% (424) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4316 | - | 0.0 | 88.92% (424) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5535 | - | 0.0 | 78.22% (427) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6286|M.smegmatis_MC2_155 -------------------------------------MSFQSLGRDDLLA
TH_1300|M.thermoresistible__bu -------------------------------------VSFHSLGRDELTA
Mflv_1280|M.gilvum_PYR-GCK -------------------------------------MSFHSLGRDELRA
Mvan_5535|M.vanbaalenii_PYR-1 -------------------------------------MSFHSLGRDELRA
MAB_0305|M.abscessus_ATCC_1997 -------------------------------------MSFLSLGSDELAA
Rv3722c|M.tuberculosis_H37Rv -------------------------------------MSFDSLSPQELAA
Mb3749c|M.bovis_AF2122/97 -------------------------------------MSFDSLSPQELAA
MMAR_5241|M.marinum_M ------------------------------------MVSFDSLSPEELAA
MUL_4316|M.ulcerans_Agy99 ------------------------------------MVSFDSLSPEELAA
MLBr_02336|M.leprae_Br4923 MRGVPYLGGAVTSAYGSGSAHDLRMSHSVRWRKGVPLVSFDSLSPDELAA
MAV_0381|M.avium_104 ------------------------------------MVSLESLTPAELAE
:*: ** :*
MSMEG_6286|M.smegmatis_MC2_155 QHELQQRNYAELQAKQLKLDLTRGKPSPEQLDLSNGLLSLPGDGADAYRD
TH_1300|M.thermoresistible__bu QYELQRRSYAELQAKNLQLDLTRGKPSPAQLDLSNRLLSLPGD--DDYRD
Mflv_1280|M.gilvum_PYR-GCK QHELQQRNYADLKAKSLRLDLTRGKPCSEQLDLSNGLLALPGTGAGAYLD
Mvan_5535|M.vanbaalenii_PYR-1 QHDEQQRNYAELQAKNLRLDLTRGKPSPDQLDLSNGLLELP--GADAFRD
MAB_0305|M.abscessus_ATCC_1997 QHRLQQENYSQLKAKGLSLDLTRGKPAPEQLDLSNGLLALPGE--GDYLD
Rv3722c|M.tuberculosis_H37Rv LHARHQQDYAALQGMKLALDLTRGKPSAEQLDLSNQLLSLPG---DDYRD
Mb3749c|M.bovis_AF2122/97 LHARHQQDYAALQGMKLALDLTRGKPSAEQLDLSNQLLSLPG---DDYRD
MMAR_5241|M.marinum_M LHVRHEQDYANLRGKGLSLDLTRGKPSSEQLDLSNQLLSLPGG--QDYRD
MUL_4316|M.ulcerans_Agy99 LHVRHEQDYANLRGKGLSLDLTRGKPSSEQLDLSNQLLSLPGG--QDYRD
MLBr_02336|M.leprae_Br4923 VHARHQQDYAELQGRKLALDLTRGKPSPEQLNLSNQLLYLPG---DDYRD
MAV_0381|M.avium_104 VHARHQQGYADLQAKKLSLDLTRGKPAPAQLDLSNALLSLPG---DDYRD
: :...*: *:. * ********.. **:*** ** ** : *
MSMEG_6286|M.smegmatis_MC2_155 GHGTDTRNYGGVQGLPELRAIFAELLGLPVENLIAGNNASLEMMHDSVVF
TH_1300|M.thermoresistible__bu ADGTDVRNYGGLHGLPELRAIFGELLGIPVPNLIAANNASLELMHDILTF
Mflv_1280|M.gilvum_PYR-GCK RDGTDTRNYGGLHGLPELRAIFGEVLGIPVPNLIAGNNASLEFMHDAIVY
Mvan_5535|M.vanbaalenii_PYR-1 AEGTDTRNYGGLHGLPELRTIFSELLGIPVPNLIAGNNASLEFMHDVVVY
MAB_0305|M.abscessus_ATCC_1997 GNGTDTRNYGGGNGLPELRAIFGELLGIPAPNLIAANNASLSLMHDVIVY
Rv3722c|M.tuberculosis_H37Rv PEGTDTRNYGGQHGLPGLRAIFAELLGIAVPNLIAGNNSSLELMHDIVAF
Mb3749c|M.bovis_AF2122/97 PEGTDTRNYGGQHGLPGLRAIFAELLGIAVPNLIAGNNSSLELMHDIVAF
MMAR_5241|M.marinum_M PEGLDTRNYGGLHGLPALRAIFGELLGIPVQNLIAGNNSSLELMHDVTAF
MUL_4316|M.ulcerans_Agy99 PEGLDTRNYGGLHGLPALRAIFGELLGIPVQSLIAGNNSSLELMHDVTAF
MLBr_02336|M.leprae_Br4923 SEGVDTRNYGGLHGLPGLRAIFAELLGIPVPNLIAGINSSLELMHDLVVF
MAV_0381|M.avium_104 SEGTDTRNYGGLHGLPELRAIFGELLGIPVQNLIAGNNSSLELMHDLVAF
.* *.***** :*** **:**.*:**:.. .***. *:**.:*** .:
MSMEG_6286|M.smegmatis_MC2_155 SLLHGGLDSPRPWSAEP----TVKFLCPAPGYDRHFAITESFGIENVPVP
TH_1300|M.thermoresistible__bu AMLHGAPDSTRPWLKEP----VVKFLCPVPGYDRHFAITENLDVEMIPVP
Mflv_1280|M.gilvum_PYR-GCK SLLHGGVDSPRPWSQEP----VVKFLCPSPGYDRHFAITESLGIEMITVP
Mvan_5535|M.vanbaalenii_PYR-1 SLLHGGVDSPRPWIDDLRNGAGVKFLCPAPGYDRHFAITESLGIEMVPVP
MAB_0305|M.abscessus_ATCC_1997 SLLHGNVDSPRPWRQES----TLKFLCPAPGYDRHFAITESFGIEMIPIP
Rv3722c|M.tuberculosis_H37Rv SMLYGGVDSPRPWIQEQDG---IKFLCPVPGYDRHFAITETMGIEMIPIP
Mb3749c|M.bovis_AF2122/97 SMLYGGVDSPRPWIQEQDG---IKFLCPVPGYDRHFAITETMGIEMIPIP
MMAR_5241|M.marinum_M SMLYGGVDSPRPWVQEPDG---IKFLCPVPGYDRHFAITETMGVEMIPVP
MUL_4316|M.ulcerans_Agy99 SMLYGGVDSPRPWVKEPDG---IKFLCPVPGYDRHFAITETMGVEMIPVP
MLBr_02336|M.leprae_Br4923 LVLYGGLDSSRPWKDEAS----VKFLCPVPGYDRHFAITETMGIEMIPIP
MAV_0381|M.avium_104 SMLYGGVDSQRPWKDEPS----VKFLCPVPGYDRHFAITETMGIEMIPVP
:*:* ** *** : :***** ***********.:.:* :.:*
MSMEG_6286|M.smegmatis_MC2_155 IREDGPDVDVIEQLVASDPTIKGIWCVPVYSNPTGATYSTDVIRRLVQMP
TH_1300|M.thermoresistible__bu IRDDGPDVDMIEELVAADPAIKGMWCIPVYSNPTGVTVSWENARRLMQMK
Mflv_1280|M.gilvum_PYR-GCK LREDGPDMDLIEELVATDPAIKGIWCIPVYSNPTGSTYSWETVRRLVQMQ
Mvan_5535|M.vanbaalenii_PYR-1 LREDGPDVDLIEELVAVDPAIKGMWCVPVYSNPTGTTYAWETVRRLVQME
MAB_0305|M.abscessus_ATCC_1997 LREDGPDVDLIEELVAADPAIKGMWTVPVFSNPTGTVYSWEVARRLVQMN
Rv3722c|M.tuberculosis_H37Rv MLQDGPDVDLIEELVAVDPAIKGMWTVPVFGNPSGVTYSWETVRRLVQMR
Mb3749c|M.bovis_AF2122/97 MLQDGPDVDLIEELVAVDPAIKGMWTVPVFGNPSGVTYSWETVRRLVQMR
MMAR_5241|M.marinum_M MLEDGPDVDLIEELVAVDPTIKGMWTVPVFGNPTGVTYSWETVRRLVQMQ
MUL_4316|M.ulcerans_Agy99 MLEDGPDVDLIEELVAVDPTIKGMWTVPVFGNPTGVTYSWETVRRLVQMQ
MLBr_02336|M.leprae_Br4923 MRHDGPDVELIEELVVVDPTIKGMWTVPVFGNPTGVTYSWETVRRLVQMR
MAV_0381|M.avium_104 MLSDGPDVGLIEELVAADPAIKGMWTVPVFGNPTGVTYSWDTVLRLVQMR
: ****: :**:**. **:***:* :**:.**:* . : : **:**
MSMEG_6286|M.smegmatis_MC2_155 TAAKDFRLMWDNAYAVHTLTDEFVEPVDVLGLAAAAGNPNRPLVFASTSK
TH_1300|M.thermoresistible__bu TAANDFRVFWDNAYAVHTLTHEFERQIDVLGLAAAAGNQNRPLVFASTSK
Mflv_1280|M.gilvum_PYR-GCK TAASDFRIMWDNAYAVHTLTRDFAQQVDILGLAAAANHANRPLVFASTSK
Mvan_5535|M.vanbaalenii_PYR-1 TAATDFRLMWDNAYAVHTLTHDFVKQVDILGLAAAANHANRPLVFASTSK
MAB_0305|M.abscessus_ATCC_1997 TAAPDFRLFWDNAYAVHTLTHDFVRNVDLLGLAETAGHPNRPLIFASTSK
Rv3722c|M.tuberculosis_H37Rv TAAPDFRLFWDNAYAVHTLTLDFPRQVDVLGLAAKAGNPNRPYVFASTSK
Mb3749c|M.bovis_AF2122/97 TAAPDFRLFWDNAYAVHTLTLDFPRQVDVLGLAAKAGNPNRPYVFASTSK
MMAR_5241|M.marinum_M TAAPDFRLFWDNAYMVHTLTPDFIRQVDVLGLAAKAGNPHRPYVFASTSK
MUL_4316|M.ulcerans_Agy99 TAAPDFRLFWDNAYMVHTLTPDFIRQVDVLGLAAKAGNPHRPYVFASTSK
MLBr_02336|M.leprae_Br4923 TAAPDFRLFWDNAYAVHTLTHDFIRQVDVLGLAAKAGNPHRPYVFASTSK
MAV_0381|M.avium_104 TAAPDFRLFWDNAYAVHTLTHDFIRQVDVLGLAAAAGNPNRPYVFASTSK
*** ***::***** ***** :* . :*:**** *.: :** :******
MSMEG_6286|M.smegmatis_MC2_155 ITFAGAGVSFLGASADNIAWYLKHAGKKSIGPDKVNQLRHLRFFGDADGV
TH_1300|M.thermoresistible__bu ITFAGAGVSFFGGSLANIAWYLQHASKKTIGPDKVNQLRHLRFFGDADGV
Mflv_1280|M.gilvum_PYR-GCK ITFAGSGVSFLGGSLGNIAWYLQHAGKRSIGPDKINQLRHARFFGDADGV
Mvan_5535|M.vanbaalenii_PYR-1 ITFAGAGVSFFGGSLGNIAWYLQHAGKKSIGPDKVNQLRHARFFGDADGV
MAB_0305|M.abscessus_ATCC_1997 ITFAGAGVSFLGGSLANIAWYLQHAGKRSIGPDKVNQLRHLRFFGDAEGV
Rv3722c|M.tuberculosis_H37Rv ITFAGGGVSFFGGSLGNIAWYLQYAGKKSIGPDKVNQLRHLRFFGDADGV
Mb3749c|M.bovis_AF2122/97 ITFAGGGVSFFGGSLGNIAWYLQYAGKKSIGPDKVNQLRHLRFFGDADGV
MMAR_5241|M.marinum_M ITFAGGGVSFFGGSLGNIAWYLQYAGKKSIGPDKVNQLRHLRFFGDADGV
MUL_4316|M.ulcerans_Agy99 ITFAGGGVSFFGGSLGNIAWYLQYAGKKSIGPDKVNQLRHLRFFGDADGV
MLBr_02336|M.leprae_Br4923 ITFAGGGVSFLGGSLGNIAWYLQYAGKKSIGPDKVNQLRHLRFFGDAEGV
MAV_0381|M.avium_104 ITFAGAGVSFFGGSLGNIAWYLQYAGKKSIGPDKVNQLRHLRFFRDADGV
*****.****:*.* ******::*.*::*****:***** *** **:**
MSMEG_6286|M.smegmatis_MC2_155 RRQMQRHRELIAPKFALVAEILEDRLGESKIASWTDPKGGYFVSLDVWPG
TH_1300|M.thermoresistible__bu RLHMHRHRELLAPKFALVAEILENRLGESKIASWTEPKGGYFVNLDVLPG
Mflv_1280|M.gilvum_PYR-GCK RLHMQRHQEILAPKFALALEILDERLGGSKIASWTEPKGGYFISLDVLPG
Mvan_5535|M.vanbaalenii_PYR-1 RLHMQRHQQLLAPKFALALEILEDRLGDSKIASWTEPKGGYFISLDVLPG
MAB_0305|M.abscessus_ATCC_1997 KLHMQKHQQILAPKFQLALEILDDRLSESKIASWSEPKGGYFISLDVLDG
Rv3722c|M.tuberculosis_H37Rv RLHMLRHQQILAPKFALVAEVLDQRLSESKIASWTEPKGGYFISLDVLPG
Mb3749c|M.bovis_AF2122/97 RLHMLRHQQILAPKFALVAEVLDQRLSESKIASWTEPKGGYFISLDVLPG
MMAR_5241|M.marinum_M RLHMRRHQQILAPKFAVALEILDQRLSDSKIASWTEPKGGYFISLDVMPG
MUL_4316|M.ulcerans_Agy99 RLHMRRHQQILAPKFAVALEILDQRLSDSKIASWTEPKGGYFISLDVMPG
MLBr_02336|M.leprae_Br4923 RLHMLRHQQILAPKFALVEEILKQRLGDSNIASWSEPKGGYFINLDVLPG
MAV_0381|M.avium_104 RLHMLRHQQILAPKFALALEILDQRLSDSKIASWTEPKGGYFISLDVLPG
: :* :*::::**** :. *:*.:**. *:****::******:.*** *
MSMEG_6286|M.smegmatis_MC2_155 TAKRTVALAKDAGIAVTEAGSAFPYRKDPEDKNIRIAPTFPSLPDVRDAI
TH_1300|M.thermoresistible__bu TAKRTVALAKAAGIAVTEAGASFPYRNDPEDKNIRIAPTFPGLDELRDAI
Mflv_1280|M.gilvum_PYR-GCK TAKRTVSLAKDAGIAVTEAGASFPYRKDPEDKNIRIAPTFPATSDLRAAI
Mvan_5535|M.vanbaalenii_PYR-1 TAKRTVALAKDAGIAVTEAGASFPYRKDPEDKNIRIAPTFPALSDLREAI
MAB_0305|M.abscessus_ATCC_1997 TAKRTVALAKEAGIALTEAGATFPYRNDPDDKNIRLAPTFPPLETVGAAV
Rv3722c|M.tuberculosis_H37Rv TARRTVALAKDVGIAVTEAGASFPYRKDPDDKNIRIAPSFPSVPDLRNAV
Mb3749c|M.bovis_AF2122/97 TARRTVALAKDVGIAVTEAGASFPYRKDPDDKNIRIAPSFPSVPDLRNAV
MMAR_5241|M.marinum_M TARRTVALAKDAGIAVTEAGASFPYRKDPEDKNIRIAPSFPSLPDLSDAV
MUL_4316|M.ulcerans_Agy99 TARRTVALAKDAGIAVTEAGASFPYRKDPEDKNIRIAPSFPSLPDLSDAV
MLBr_02336|M.leprae_Br4923 TARRTVALAKAAGIAVTEAGASFPYRKDPDDKNIRVAPSYPSMSELRNAV
MAV_0381|M.avium_104 TAKRTVALAKDAGIAVTEAGASFPYRKDPNDTNIRIAPTFPSLPDLRDAV
**:***:*** .***:****::****:**:*.***:**::* : *:
MSMEG_6286|M.smegmatis_MC2_155 DGLATCALLAATEALLGDK---------
TH_1300|M.thermoresistible__bu DGLATCALLAATESLVGANR--------
Mflv_1280|M.gilvum_PYR-GCK DGLSTCALLAALEHLLAAE---------
Mvan_5535|M.vanbaalenii_PYR-1 DGLATCALLSATEQLLALPAEK------
MAB_0305|M.abscessus_ATCC_1997 DGLATCALLAATEKLLERGA--------
Rv3722c|M.tuberculosis_H37Rv DGLATCALLAATETLLNQGLASSAPNVR
Mb3749c|M.bovis_AF2122/97 DGLATCALLAATETLLNQGLASSAPNVR
MMAR_5241|M.marinum_M DGLATCALLAGTEALLAR------P---
MUL_4316|M.ulcerans_Agy99 DGLATCALLAGTEALLAR------P---
MLBr_02336|M.leprae_Br4923 DGLATCALLAASESLLNARC--------
MAV_0381|M.avium_104 DGLATCALLAASESLLARDRV-------
***:*****:. * *: