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M. tuberculosis H37Rv Rv3710 (leuA)

annotation: 2-isopropylmalate synthase
coordinates: 4153860 - 4155674
length: 604

VTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRVIDR
APLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTI
QVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQ
WRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV
ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRR
TVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR
TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLA
PVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMS
AGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTA
SLRAVVSAVNRAAR
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv3710leuA-100% (604)2-isopropylmalate synthase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3737leuA0.099.83% (574) 2-isopropylmalate synthase
M. gilvum PYR-GCKMflv_1293-0.080.13% (604) 2-isopropylmalate synthase
M. leprae Br4923MLBr_02324leuA0.082.06% (602) 2-isopropylmalate synthase
M. abscessus ATCC 19977MAB_0337c-0.077.81% (604) 2-isopropylmalate synthase
M. marinum MMMAR_5225leuA0.085.93% (604) 2-isopropylmalate synthase LeuA
M. avium 104MAV_0392leuA0.084.44% (604) 2-isopropylmalate synthase
M. smegmatis MC2 155MSMEG_6271leuA0.076.82% (604) 2-isopropylmalate synthase
M. thermoresistible (build 8)TH_2283leuA0.078.28% (603) 2-ISOPROPYLMALATE SYNTHASE LEUA (ALPHA-ISOPROPYLMALATE
M. ulcerans Agy99MUL_4300leuA0.085.43% (604) 2-isopropylmalate synthase
M. vanbaalenii PYR-1Mvan_5515-0.077.92% (607) 2-isopropylmalate synthase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1293|M.gilvum_PYR-GCK          ----MTENYNPSADAFSSVRTIVTPAGKPNPGQPSWNTQRASSMPVNRYR
Mvan_5515|M.vanbaalenii_PYR-1       ----MTENYSPSADAYSSVRTITTPAGPPNPGQPSWNTQRGSSMPVSRYR
MSMEG_6271|M.smegmatis_MC2_155      -----MNTPDISSDAFSTGRTITPPSGAPHPGQPAWNTQRGSSMPVSRYR
TH_2283|M.thermoresistible__bu      -----VTNPIPSPDAYSSVRAITTPSGGRREGQPPWNPQQNSSMPVSRYR
MAB_0337c|M.abscessus_ATCC_199      ------MTSFSSDEFNYTPRSVVTPNGPIPADQPAWNTQKNSSMPVHRYR
Rv3710|M.tuberculosis_H37Rv         -------------------------------------------MPVNRYR
Mb3737|M.bovis_AF2122/97            -------------------------------------------MPVNRYR
MMAR_5225|M.marinum_M               ---MTNSSQAPGPDAFTSARTIVKPAGPPSPGQPVWNPQRASSMPVNRYR
MUL_4300|M.ulcerans_Agy99           -------------------------------------------MPVNRYR
MLBr_02324|M.leprae_Br4923          MASFSESLSQDPADAYKSAPSITKPMGPPSPGQPQWNPQRATSMPVFRYR
MAV_0392|M.avium_104                --------MTSHPDAFSSSRSIVKPAGPPGPGQPAWNPQRGSSMPVNRYR
                                                                               *** ***

Mflv_1293|M.gilvum_PYR-GCK          SFDDEV---EPIRLPDRTWPEKAITTAPMWAAVDLRDGNQALIDPMSPQR
Mvan_5515|M.vanbaalenii_PYR-1       NFAAEVPGGAPAAPFDRTWPDKVIDTAPLWCAVDLRDGNQALIDPMSPAR
MSMEG_6271|M.smegmatis_MC2_155      SFADEV---EKISLPDRTWPDKVIETAPMWCAVDLRDGNQALIDPMSPQR
TH_2283|M.thermoresistible__bu      SFADEV---EHITLPDRTWPDKVIDRAPLWCAVDLRDGNQALIDPMSPAR
MAB_0337c|M.abscessus_ATCC_199      SFTDEV---EKIELPDRTWPDKVITRAPQWGAVDLRDGNQALIDPMSPAR
Rv3710|M.tuberculosis_H37Rv         PFAEEV---EPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPAR
Mb3737|M.bovis_AF2122/97            PFAEEV---EPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPAR
MMAR_5225|M.marinum_M               PFAEEV---EHIRVTDRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPAR
MUL_4300|M.ulcerans_Agy99           PFAEEV---EHIRVTDRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPAR
MLBr_02324|M.leprae_Br4923          PFAKEV---EPIRLVDRTWPDRVIDCAPLWCAVDLRDGNQALIDPMSPIC
MAV_0392|M.avium_104                PFAEEV---EPIRLPDRTWPDKVIDRAPLWCAVDLRDGNQALIDPMSPAR
                                     *  **         :****::.*  ** * *****************  

Mflv_1293|M.gilvum_PYR-GCK          KRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLT
Mvan_5515|M.vanbaalenii_PYR-1       KRRMFDLLVKMGYKEIEVGFPSASQTDYDFVREIIEQGAIPDDVTIQVLT
MSMEG_6271|M.smegmatis_MC2_155      KRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEDNAIPDDVTIQVLT
TH_2283|M.thermoresistible__bu      KRRMFDLLVRMGYKEIEVGFPSASQTDYDFVREIITDNAIPDDVTIQVLT
MAB_0337c|M.abscessus_ATCC_199      KRRMFDLQIRMGFKEIEVGFPSASQTDFDFIRELITENAIPDDVTIQVLT
Rv3710|M.tuberculosis_H37Rv         KRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLT
Mb3737|M.bovis_AF2122/97            KRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLT
MMAR_5225|M.marinum_M               KRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIITEGAIPDDVTIQVLT
MUL_4300|M.ulcerans_Agy99           KRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIITEGAIPDDVTIQVLT
MLBr_02324|M.leprae_Br4923          KRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIITDGTIPDDVTIQVLT
MAV_0392|M.avium_104                KRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIVTEGAIPDDVTIQVLT
                                    ******* ::**:**************:**:**:: :.:***********

Mflv_1293|M.gilvum_PYR-GCK          QCRPELIERTFLACQGAPRAIVHFYNSTSILQRRVVFRADRDAVKQIATD
Mvan_5515|M.vanbaalenii_PYR-1       QCRDELIERTFEACDGAPNVIVHFYNSTSILQRRVVFRADRDEIKKIATD
MSMEG_6271|M.smegmatis_MC2_155      QSRPELITRTFEACRGAKNVIVHFYNSTSILQRRVVFRADKAAIKKIATD
TH_2283|M.thermoresistible__bu      QCRPELIEKTFEACQGAPRVIVHFYNSTSILQRRVVFRADREEVKQIAVE
MAB_0337c|M.abscessus_ATCC_199      QCRPELIERTFLACEGASKVIVHFYNSTSILQRRVVFREDKDAIKKIATD
Rv3710|M.tuberculosis_H37Rv         QCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAEVQAIATD
Mb3737|M.bovis_AF2122/97            QCRPELIERTFQACSGAHRAIVHFYNSTSILQRRVVFRANRAEVQAIATD
MMAR_5225|M.marinum_M               QCRPELIERTFEACAGASKVIVHFYNSTSILQRRVVFRADRAAVQAIATE
MUL_4300|M.ulcerans_Agy99           QCRPELIERTFEACAGASKVIVHFYNSTSILQRRVVFRADRAAVEAIATD
MLBr_02324|M.leprae_Br4923          QCRPELIERTFEACENASRVIVHFYNSTSILQRRVVFRADQATVKAIATD
MAV_0392|M.avium_104                QCRPELIERTFAACQGAPQAIVHFYNSTSILQRRVVFRADRAAVQEIAVA
                                    *.* *** :** ** .* ..****************** ::  :: **. 

Mflv_1293|M.gilvum_PYR-GCK          GARMCVEEAKKYPGTQWRYEYSPESYTGTELEYAVEVCNAVAEVVQPTPE
Mvan_5515|M.vanbaalenii_PYR-1       GARKCLEEAGKHPGTRWRYEYSPESYTGTELEYALDVCNAVSEVIEPTPD
MSMEG_6271|M.smegmatis_MC2_155      AAELVLEEAKKYPDTNWRWEYSPESYTGTELSYAKEVCDAVTEILGATPD
TH_2283|M.thermoresistible__bu      GARMCLAEAEKYPGTLWRYEYSPESYTGTELQYAAEVCNAVAEVIEPTPE
MAB_0337c|M.abscessus_ATCC_199      GAHKCVEEAAKYPDTHWRFQYSPESYTGTELQYALEVCNAVGDIVEPTPD
Rv3710|M.tuberculosis_H37Rv         GARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPE
Mb3737|M.bovis_AF2122/97            GARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPE
MMAR_5225|M.marinum_M               GARRCVEEAAKYPDTQWRFEYSPESYTGTELEYAKQVCDAVAEVIQPTPE
MUL_4300|M.ulcerans_Agy99           GARRCVEEAAKYPDTQWRFEYSPESYTGTELEYAKQVCDAVAEVIQPTPE
MLBr_02324|M.leprae_Br4923          GARKCVEEAFKYPGTHWRFEYSPESYTGTELEYAKQVCDAVGEVIQPTPD
MAV_0392|M.avium_104                GARKCVEEAAKYPETRWRFEYSPESYTGTELEYAKQVCDAVGEIIRPTPE
                                    .*.  : :* *:* * **::***********.** :**:** ::: .**:

Mflv_1293|M.gilvum_PYR-GCK          WPLIVNLPATVEMATPNVYADSIEWMHRHLTPRDSIILSLHPHNDRGTAV
Mvan_5515|M.vanbaalenii_PYR-1       WPLIVNLPATVEMATPNVYADSIEWMSRNLARRGSIILSLHPHNDRGTAV
MSMEG_6271|M.smegmatis_MC2_155      NPVILNLPATVEMATPNVYADSIEWMHRNLARRDSVILSLHPHNDRGTGV
TH_2283|M.thermoresistible__bu      WPLIVNLPATVEMATPNVYADSIEWMSRRLTPRDSIILSLHPHNDRGTAV
MAB_0337c|M.abscessus_ATCC_199      NPIIFNLPSTVEMTTPNVYADSIEWMSRNLARRDSVILSLHPHNDRGTAV
Rv3710|M.tuberculosis_H37Rv         RPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAV
Mb3737|M.bovis_AF2122/97            RPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAV
MMAR_5225|M.marinum_M               NPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAV
MUL_4300|M.ulcerans_Agy99           NPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAV
MLBr_02324|M.leprae_Br4923          NPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAV
MAV_0392|M.avium_104                NPIIFNLPATVEMATPNVYADSIEWMSRNLARRDSVILSLHPHNDRGTAV
                                     *:*.***:****:************ *.*: * *:************.*

Mflv_1293|M.gilvum_PYR-GCK          AAAELGYAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSN
Mvan_5515|M.vanbaalenii_PYR-1       AAAELGYQAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSN
MSMEG_6271|M.smegmatis_MC2_155      AAAELGYQAGADRIEGCLFGNGERTGNVCLVTLGLNMFSRGVDPQIDFSN
TH_2283|M.thermoresistible__bu      AAAELGYQAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSN
MAB_0337c|M.abscessus_ATCC_199      AAAELGFQAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSN
Rv3710|M.tuberculosis_H37Rv         AAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSN
Mb3737|M.bovis_AF2122/97            AAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSN
MMAR_5225|M.marinum_M               AAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSN
MUL_4300|M.ulcerans_Agy99           AAAELGFAAGADRIEGCLFGNGERTGNVCLATLGLNLFSRGVDPQIDFSN
MLBr_02324|M.leprae_Br4923          AAAELGYHAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSN
MAV_0392|M.avium_104                AAAELGYAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSN
                                    ******: **********************.*****:*************

Mflv_1293|M.gilvum_PYR-GCK          IDEIRRTVEYCNQLAVPERHPYGGDLVYTAFSGSHQDAINKGLDAMKFDA
Mvan_5515|M.vanbaalenii_PYR-1       IDEIRRTVEYCNQLGVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKISA
MSMEG_6271|M.smegmatis_MC2_155      IDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDQMKVDA
TH_2283|M.thermoresistible__bu      IDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGFDQMKIDA
MAB_0337c|M.abscessus_ATCC_199      IDEIRHTVEYCNQLKVPERHPYGGDLVYTAFSGSHQDAINKGLDQMKRDA
Rv3710|M.tuberculosis_H37Rv         IDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDA
Mb3737|M.bovis_AF2122/97            IDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDA
MMAR_5225|M.marinum_M               IDEIRRTVEYCNQLPVPERHPYGGDLVYTAFSGSHQDAINKGLDAMKFDA
MUL_4300|M.ulcerans_Agy99           IDEIRRTVEYCNQLPVPERHPYGGDLVYTAFSGSHQDAINKGLDAMEFDA
MLBr_02324|M.leprae_Br4923          IDEIRRTVEYCNKLRVHERHPYGGDLVYTAFSGSHQDAINKGLDQMKIDA
MAV_0392|M.avium_104                IDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDQMEIDA
                                    *****:******:* * *************************:* *: .*

Mflv_1293|M.gilvum_PYR-GCK          DAADKDVDDLLWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKAD
Mvan_5515|M.vanbaalenii_PYR-1       DEQDSDVDDIVWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKAD
MSMEG_6271|M.smegmatis_MC2_155      DAAGADMDDILWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKAD
TH_2283|M.thermoresistible__bu      DTAGVDVDDLLWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKTD
MAB_0337c|M.abscessus_ATCC_199      DEADSDVDDILWQVPYLPIDPKDVGRNYEAVIRVNSQSGKGGVAYIMKSD
Rv3710|M.tuberculosis_H37Rv         DAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTD
Mb3737|M.bovis_AF2122/97            DAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTD
MMAR_5225|M.marinum_M               DAADSDMDDMLWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKAD
MUL_4300|M.ulcerans_Agy99           DAADSDMDDMLWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKAD
MLBr_02324|M.leprae_Br4923          DAADSDVDDILWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKAD
MAV_0392|M.avium_104                DAADTDVEDMLWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKAD
                                    *  . *::*::**********:****.*********************:*

Mflv_1293|M.gilvum_PYR-GCK          HGLALPRRLQIEFSQVIQQITD---GEGGEVSPKEMWDAFYEEYLAPVTP
Mvan_5515|M.vanbaalenii_PYR-1       HGLALPRRLQIEFSQAIQQITD---GEGGEVSPKEMWDAFYDEYLAPITP
MSMEG_6271|M.smegmatis_MC2_155      HGLVLPRRLQIEFSQVIQQITD---GEGGEVSPKEMWDAFSEEYLAPITP
TH_2283|M.thermoresistible__bu      HGLVLPRRLQIEFSQVVQAITD---GEGGEVSAKEMWDVFAEEYLNPIRP
MAB_0337c|M.abscessus_ATCC_199      HGLVLPRRLQIEFAQSIQRITD---GEGGEVNPKEIWDVFAEEYLAPITP
Rv3710|M.tuberculosis_H37Rv         HGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRP
Mb3737|M.bovis_AF2122/97            HGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRP
MMAR_5225|M.marinum_M               HGLALPRRLQIEFSRAIQEIAEGSAGEGGEVSPKEMWDAFAEEYLAPVRP
MUL_4300|M.ulcerans_Agy99           HGLALPRRLQIEFSRAIQEIAEGSAGEGGEVSPKEMWDAFAEEYLAPVRP
MLBr_02324|M.leprae_Br4923          HGLELPRRLQIEFSRAIQKISE---GEGGEITPTEMWDVFFEEYLSPVQP
MAV_0392|M.avium_104                HGLALPRRLQIEFSQVIQKISE---GEGGEVSPKEMWDAFFEEYLAPVWP
                                    *** *********:: :* *::   *****:...*:**.* :*** *: *

Mflv_1293|M.gilvum_PYR-GCK          LERIRQKVDAAEVDGGTDTITAVVKIDGEEREIVGAGNGPLAAFVDAVGA
Mvan_5515|M.vanbaalenii_PYR-1       LERIRQKVDASEVDGGTDTITAVVKVNGEEHEIVGAGNGPLAAFVDAIGA
MSMEG_6271|M.smegmatis_MC2_155      LERMRQKVDAAEEDGGTDKITAVVKVNGEEREIVGAGNGPLAAFCDALGA
TH_2283|M.thermoresistible__bu      LERIRQKVIASEVDDGVDRIEAVVKVDGVEKEIAGKGNGPLAAFVDALGT
MAB_0337c|M.abscessus_ATCC_199      LERIRQKVTASEEDGGTDSIAAVVKIDGKETEVNGTGNGPLAAFVDALST
Rv3710|M.tuberculosis_H37Rv         LERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALAD
Mb3737|M.bovis_AF2122/97            LERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALAD
MMAR_5225|M.marinum_M               LERIKQRVIAAEEDGGTTSIDATVKIDGKETEISGSGNGPLAAFVHALGS
MUL_4300|M.ulcerans_Agy99           LERIKQRVIAAEEDGGTTSIDATVKIDGKEAEISGSGNGPLAAFVHALGT
MLBr_02324|M.leprae_Br4923          LERIKQRVNAAEEDGGSTSIAATVKINGEETEISGVGNGPLAAFIDALGH
MAV_0392|M.avium_104                LERVKQRVDASDEDSGVTSISATVKINGEQTEINGTGNGPLAAFVHALAG
                                    ***::*:* *:: *.*   * *.**::* : *: * ******** .*:. 

Mflv_1293|M.gilvum_PYR-GCK          VGFNVNVLDYSEHAMSAGEEAQAAAYVEAEIDG-----------------
Mvan_5515|M.vanbaalenii_PYR-1       VGFHVNVLDYSEHAMSAGEEAAAAAYVEAEIDG-----------------
MSMEG_6271|M.smegmatis_MC2_155      LGINVNVRDYSEHAMSAGEEAQAAAYVEAEIDG-----------------
TH_2283|M.thermoresistible__bu      VGFDVSVLDYSEHAMSAGEEAQAAAYVEAAVNG-----------------
MAB_0337c|M.abscessus_ATCC_199      VGYTVNVLDYSEHALSAGDDAQAAAYVEATVVSPGGGE------------
Rv3710|M.tuberculosis_H37Rv         VGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPV
Mb3737|M.bovis_AF2122/97            VGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPV
MMAR_5225|M.marinum_M               VGFDVAVLDYSEHAMSAGDDAQAAAYVEASVAG-----------------
MUL_4300|M.ulcerans_Agy99           VGFDVAVLDYSEHAMSAGDDAQAAAYVEASVAG-----------------
MLBr_02324|M.leprae_Br4923          VGLQVAVLDYSEHAMNAGDDAQAAAYVEASVHG-----------------
MAV_0392|M.avium_104                VGFDVAVLDYSEHAMSSGDDAQAAAYVEASVNG-----------------
                                    :*  * * ** ***:.:*::* ******* :                   

Mflv_1293|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_5515|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_6271|M.smegmatis_MC2_155      --------------------------------------------------
TH_2283|M.thermoresistible__bu      --------------------------------------------------
MAB_0337c|M.abscessus_ATCC_199      --------------------------------------------------
Rv3710|M.tuberculosis_H37Rv         TIASPAQPGEAG--------------------------------------
Mb3737|M.bovis_AF2122/97            TIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAG
MMAR_5225|M.marinum_M               --------------------------------------------------
MUL_4300|M.ulcerans_Agy99           --------------------------------------------------
MLBr_02324|M.leprae_Br4923          --------------------------------------------------
MAV_0392|M.avium_104                --------------------------------------------------
                                                                                      

Mflv_1293|M.gilvum_PYR-GCK          ----------------------------RTVWGVGIATSITTASLRAVVS
Mvan_5515|M.vanbaalenii_PYR-1       ----------------------------KTVWGVGIATSITTASLRAVVS
MSMEG_6271|M.smegmatis_MC2_155      ----------------------------KTVWGVGIATSITTASLRAVVS
TH_2283|M.thermoresistible__bu      ----------------------------TTVWGVGIATSITTASLRAVVS
MAB_0337c|M.abscessus_ATCC_199      ---------------------------AQTVWGVGIAPSITTASLRAVVS
Rv3710|M.tuberculosis_H37Rv         -------------------RHASDPVTSKTVWGVGIAPSITTASLRAVVS
Mb3737|M.bovis_AF2122/97            RHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVS
MMAR_5225|M.marinum_M               ----------------------------KTVWGVGIAPSITTASLRAVVS
MUL_4300|M.ulcerans_Agy99           ----------------------------KTVWGVGIAPSITTASLRAVVS
MLBr_02324|M.leprae_Br4923          ----------------------------HTAWGVGIAPSITTASLRAVVS
MAV_0392|M.avium_104                ----------------------------RTVWGVGIAPSITTASLRAVVS
                                                                 *.******.************

Mflv_1293|M.gilvum_PYR-GCK          AVNRAARLTAA---
Mvan_5515|M.vanbaalenii_PYR-1       AVNRAMRTRPSLLR
MSMEG_6271|M.smegmatis_MC2_155      AVNRAARA------
TH_2283|M.thermoresistible__bu      AVNRAAARS-----
MAB_0337c|M.abscessus_ATCC_199      AVNRAARA------
Rv3710|M.tuberculosis_H37Rv         AVNRAAR-------
Mb3737|M.bovis_AF2122/97            AVNRAAR-------
MMAR_5225|M.marinum_M               AINRASR-------
MUL_4300|M.ulcerans_Agy99           AINRASR-------
MLBr_02324|M.leprae_Br4923          AVNRAMPR------
MAV_0392|M.avium_104                AVNRAARA------
                                    *:***