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ADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARL GVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEI TEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRM AFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALA AGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLS ESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYE LIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLP HLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSW VAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGI NLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEEL FATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMD LQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEP KRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRAR GPAKRPARKAARKVPAKKAAKRD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3646c | topA | - | 100% (934) | DNA topoisomerase I |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3670c | topA | 0.0 | 100.00% (934) | DNA topoisomerase I |
| M. gilvum PYR-GCK | Mflv_1394 | - | 0.0 | 79.77% (939) | DNA topoisomerase I |
| M. leprae Br4923 | MLBr_00200 | topA | 0.0 | 84.71% (935) | DNA topoisomerase I |
| M. abscessus ATCC 19977 | MAB_0489 | - | 0.0 | 78.41% (931) | DNA topoisomerase I |
| M. marinum M | MMAR_5138 | topA | 0.0 | 87.29% (936) | DNA topoisomerase I TopA |
| M. avium 104 | MAV_0519 | topA | 0.0 | 86.62% (934) | DNA topoisomerase I |
| M. smegmatis MC2 155 | MSMEG_6157 | topA | 0.0 | 81.12% (932) | DNA topoisomerase I |
| M. thermoresistible (build 8) | TH_0857 | topA | 0.0 | 80.17% (928) | DNA TOPOISOMERASE I TOPA (OMEGA-PROTEIN) (RELAXING ENZYME) |
| M. ulcerans Agy99 | MUL_4222 | topA | 0.0 | 86.65% (936) | DNA topoisomerase I |
| M. vanbaalenii PYR-1 | Mvan_5396 | - | 0.0 | 79.01% (948) | DNA topoisomerase I |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1394|M.gilvum_PYR-GCK MADGD---RGS---GKNGS---------VRRLVIVESPTKARKIAGYLGS
Mvan_5396|M.vanbaalenii_PYR-1 MADEE---RGS---GKNGAEPRRGNGSSVRRLVIVESPTKARKIAGYLGS
MSMEG_6157|M.smegmatis_MC2_155 MAGGD---RGS---GGTGN---------VRRLVIVESPTKARKIAGYLGS
TH_0857|M.thermoresistible__bu LAEQD---RGS---GRNGS---------VRRLVIVESPTKARKIAGYLGS
Rv3646c|M.tuberculosis_H37Rv MADPKTKGRGS---GGNGS---------GRRLVIVESPTKARKLASYLGS
Mb3670c|M.bovis_AF2122/97 MADPKTKGRGS---GGNGS---------GRRLVIVESPTKARKLASYLGS
MLBr_00200|M.leprae_Br4923 MKGPR--GSRS---GRNGS---------PRRLVIVESPTKARKLSGYLGS
MMAR_5138|M.marinum_M MADPKTKGPGSRSSGGNGS---------GRRLVIVESPTKARKLAGYLGP
MUL_4222|M.ulcerans_Agy99 MADPKTKGPGSRSSGGNGS---------GRRLVIVESPTKARKLAGYLGP
MAV_0519|M.avium_104 MADPKLKENTS---GGNGS---------RRRLVIVESPTKARKLASYLGS
MAB_0489|M.abscessus_ATCC_1997 ----------------------------MRRLVIVESPTKARKIAGYLGD
**************::.***
Mflv_1394|M.gilvum_PYR-GCK NYVVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADFEPLYIISPD
Mvan_5396|M.vanbaalenii_PYR-1 NYIVESSRGHIRDLPRNAADVPAKYKSEPWARLGVNVEHNFEPLYIISPD
MSMEG_6157|M.smegmatis_MC2_155 NYVVESSRGHIRDLPRNAADVPAKFKSEPWARLGVNVDQNFEPLYIVSPE
TH_0857|M.thermoresistible__bu DYIVESSRGHIRDLPRNAADVPAKYKSEPWARLGVDVDNDFQPLYIISPD
Rv3646c|M.tuberculosis_H37Rv GYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPE
Mb3670c|M.bovis_AF2122/97 GYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPE
MLBr_00200|M.leprae_Br4923 AYIVESSRGHIRDLPRTAADVPAKFKSEPWARLGVNVDADFEPLYIITPE
MMAR_5138|M.marinum_M RYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADFEPLYIISPE
MUL_4222|M.ulcerans_Agy99 RYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADFEPLYIISPE
MAV_0519|M.avium_104 RYIVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADFEPLYIISPE
MAB_0489|M.abscessus_ATCC_1997 GYVVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADFEPLYIVSPD
*:************* *:*****:**:*******:*: :*:****::*:
Mflv_1394|M.gilvum_PYR-GCK KKATVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVF
Mvan_5396|M.vanbaalenii_PYR-1 KKSTVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVF
MSMEG_6157|M.smegmatis_MC2_155 KKSTVTELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPRVPVKRMVF
TH_0857|M.thermoresistible__bu KKSTVTELKNKLKEADELYLATDGDREGEAIAWHLLETLKPKVPVKRMVF
Rv3646c|M.tuberculosis_H37Rv KRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVF
Mb3670c|M.bovis_AF2122/97 KRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVF
MLBr_00200|M.leprae_Br4923 KKSTVTELKGLLQGVDELYLATDGDREGEAIAWHLMQTLKPRVPVKRMVF
MMAR_5138|M.marinum_M KKSAVSELKDLLKDVDELYLATDGDREGEAIAWHLLETLKPRVPVKRMVF
MUL_4222|M.ulcerans_Agy99 KKSAVSELKDLLKDVDELYLATDGDREGEAIAWHLLETLKPRVPVKRMVF
MAV_0519|M.avium_104 KKHTVSELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPNIPVKRMVF
MAB_0489|M.abscessus_ATCC_1997 KKGTVTELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPKVPVRRMVF
*: :*::*:. *: .********************::****.:**:****
Mflv_1394|M.gilvum_PYR-GCK HEITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAP
Mvan_5396|M.vanbaalenii_PYR-1 HEITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAP
MSMEG_6157|M.smegmatis_MC2_155 HEITEPAIRNAAENPRDLDIALVDAQETRRILDRLYGYEVSPVLWKKVAP
TH_0857|M.thermoresistible__bu HEITESAIRNAAENPRDLDTALVDAQETRRILDRLYGYEVSPVLWKKVAP
Rv3646c|M.tuberculosis_H37Rv HEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAP
Mb3670c|M.bovis_AF2122/97 HEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAP
MLBr_00200|M.leprae_Br4923 HEITEHAILAAAAHPRELDIDLVDAQETRRILDRLYGYEVSPVLWKKVAP
MMAR_5138|M.marinum_M HEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAP
MUL_4222|M.ulcerans_Agy99 HEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAP
MAV_0519|M.avium_104 HEITEPAILEAAENPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAP
MAB_0489|M.abscessus_ATCC_1997 HEITEQAILAAAQDPRDLDNNLVDAQETRRILDRLYGYEVSPVLWKKVGR
***** ** ** .**:** ***************************.
Mflv_1394|M.gilvum_PYR-GCK KLSAGRVQSVATRIIVQRERERMAFRSAGYWDVTAELDASVSDAQATPPT
Mvan_5396|M.vanbaalenii_PYR-1 KLSAGRVQSVATRIIVQRERERMAFRSAGYWDVTAELDASVSDAQASPPT
MSMEG_6157|M.smegmatis_MC2_155 KLSAGRVQSVATRIIVQRERERMAFHSASYWDVTAELDASVSDPSASPPK
TH_0857|M.thermoresistible__bu KLSAGRVQSVATRIIVQRERERMAFRSASYWDVTAQLDASVSDPQASPPV
Rv3646c|M.tuberculosis_H37Rv KLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPT
Mb3670c|M.bovis_AF2122/97 KLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPT
MLBr_00200|M.leprae_Br4923 KLSAGRVQSVATRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTAQPLT
MMAR_5138|M.marinum_M KLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPT
MUL_4222|M.ulcerans_Agy99 KLSAGRVQSVATRMIVQRERDRMAFRRASYWDIVATLDASVSDPKAAPPT
MAV_0519|M.avium_104 KLSAGRVQSVATRIIVQRERDRMAFRSASYWDIVAQLDASVSDPQASPPT
MAB_0489|M.abscessus_ATCC_1997 NLSAGRVQSVATRIIVQRERDRMAFRSAGYWDLGAELDAGKDNPAAKPPR
:************:** ***:**** * ***: * ***. .:. * *
Mflv_1394|M.gilvum_PYR-GCK FVAKLNTVDGRRVAAGRDFDSLGAVK---KPGEVLVLDEAAANALAGGLR
Mvan_5396|M.vanbaalenii_PYR-1 FVAKLNTVDGRRVATGRDFDSLGAVR---KPDEVLVLDEAAANALATGLR
MSMEG_6157|M.smegmatis_MC2_155 FTAKLNTVDGRRVATGRDFDSLGQLK---RPDEVLVLDEASAGALASGLR
TH_0857|M.thermoresistible__bu FAAKLSTVDGRRVATGRDFDSRGVVK---KPDEVLVLDESDANALVAGLR
Rv3646c|M.tuberculosis_H37Rv FSARLTAVAGRRVATGRDFDSLGTLR---KGDEVIVLDEGSATALAAGLD
Mb3670c|M.bovis_AF2122/97 FSARLTAVAGRRVATGRDFDSLGTLR---KGDEVIVLDEGSATALAAGLD
MLBr_00200|M.leprae_Br4923 FVARLTAVDGLRVATGRDFGAMGTLRGDCEVSKIIVLDDLTATTLAAGLR
MMAR_5138|M.marinum_M FVARLTSVDGLRVATGRDFDSLGTLR---KADEVTVLDEARAAALATGLH
MUL_4222|M.ulcerans_Agy99 FVARLTSVDGLRVATGRDFDSLGTLR---KADEVTVLDEARAAALATGLH
MAV_0519|M.avium_104 FAARLTSVDGLRVATGRDFDSQGQLR---KADEVIVLDEPQATELAAGLQ
MAB_0489|M.abscessus_ATCC_1997 FHARLVSVDALRVASGRDFDSLGQVKETSNGPGVLVLDETRANALVAGLS
* *:* :* . ***:****.: * :: . : ***: * *. **
Mflv_1394|M.gilvum_PYR-GCK GAQLSVSSVEQKPYTRRPYAPFMTSTLQQEAGRKLRMSSERTMSIAQRLY
Mvan_5396|M.vanbaalenii_PYR-1 GAQLAVSSVEQKPYTRRPYAPFMTSTLQQEAGRKLRFTSERTMSIAQRLY
MSMEG_6157|M.smegmatis_MC2_155 GAQLAVTSVEQKPYTRRPYAPFMTSTLQQEAARKLRFSSERTMSIAQRLY
TH_0857|M.thermoresistible__bu NVQLTVTSVEQKPYTRRPYAPFMTSTLQQEAGRKLRFSAERTMSIAQRLY
Rv3646c|M.tuberculosis_H37Rv GTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLY
Mb3670c|M.bovis_AF2122/97 GTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLY
MLBr_00200|M.leprae_Br4923 GAQLTVASAEEKLYTRRPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLY
MMAR_5138|M.marinum_M GAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLY
MUL_4222|M.ulcerans_Agy99 GAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLY
MAV_0519|M.avium_104 GAQLSVASVEEKPYTRRPYAPFMTSTLQQEAGRKLRFSAERTMSIAQRLY
MAB_0489|M.abscessus_ATCC_1997 QATLTVVSAEEKPYTRKPYPPFMTSTLQQEAGRKLRFSSERTMSIAQRLY
. *:* *.*:* *:*:**.***********.****::.***********
Mflv_1394|M.gilvum_PYR-GCK ENGYITYMRTDSTTLSQSAIDAARNQARQLYGEEYVHPTPRQYTRKVKNA
Mvan_5396|M.vanbaalenii_PYR-1 ENGYITYMRTDSTTLSQSAIDAARNQARQLYGEEYVHPTPRQYTRKVKNA
MSMEG_6157|M.smegmatis_MC2_155 ENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVHPSPRQYTRKVKNA
TH_0857|M.thermoresistible__bu ENGYITYMRTDSITLSQSAINAARNQARQLYGEEYVHPTPRQYSRKVKNA
Rv3646c|M.tuberculosis_H37Rv ENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNA
Mb3670c|M.bovis_AF2122/97 ENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNA
MLBr_00200|M.leprae_Br4923 ENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVSDSPRQYTRKVKNA
MMAR_5138|M.marinum_M ENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYTRKVKNA
MUL_4222|M.ulcerans_Agy99 ENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYTRKVKNA
MAV_0519|M.avium_104 ENGYITYMRTDSTTLSGSAINAARTQARQLYGEEYVSPSPRQYTRKVKNA
MAB_0489|M.abscessus_ATCC_1997 ENGYITYMRTDSTTLSDSALQAARSQAAELYGNEYVHPSPRQYTRKVKNA
************ *** **::***.** :***:*** :****:******
Mflv_1394|M.gilvum_PYR-GCK QEAHEAIRPAGDVFQTPGQLHSQLDT---DEFRLYELIWQRTVASQMADA
Mvan_5396|M.vanbaalenii_PYR-1 QEAHEAIRPAGDVFQTPGQLHSQLDT---DEFRLYELIWQRTVASQMADA
MSMEG_6157|M.smegmatis_MC2_155 QEAHEAIRPAGDVFQTPGQLHSALDT---DEFRLYELIWQRTVASQMADA
TH_0857|M.thermoresistible__bu QEAHEAIRPAGDVFATPGQLANELAP---DEFRLYELIWQRTVASQMADA
Rv3646c|M.tuberculosis_H37Rv QEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADA
Mb3670c|M.bovis_AF2122/97 QEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADA
MLBr_00200|M.leprae_Br4923 QEAHEAIRPAGETFATPDAVCNELDG---DEFRIYELVWRRTVASQMADA
MMAR_5138|M.marinum_M QEAHEAIRPAGETFATPDAVRRELDG---DEFRLYELIWQRTVASQMADA
MUL_4222|M.ulcerans_Agy99 QEAHEAIRPAGETFATPDAVRRELDG---DEFRLYELIWQRTVASQMADA
MAV_0519|M.avium_104 QEAHEAIRPAGETFATPDAVRRELDG---DEFRLYELIWQRTVASQMADA
MAB_0489|M.abscessus_ATCC_1997 QEAHEAIRPAGETFKTPGQLHSSLDN---DEFRLYELIWQRTVASQMADA
***********:.* **. : * *:**:***:*:**********
Mflv_1394|M.gilvum_PYR-GCK RGTTLSLRIAGAA---------TSGEQVVFNASGRTITFAGFLKAYVESL
Mvan_5396|M.vanbaalenii_PYR-1 RGTTLSLRIAGAAPATTLGGGTASDVQVVFNASGRTITFPGFLKAYVESI
MSMEG_6157|M.smegmatis_MC2_155 RGTTLSLRIGGSA---------SSGEQVVFNASGRTITFPGFLKAYVESI
TH_0857|M.thermoresistible__bu RGTTLSLRISGTT---------ADGRQVVFTASGRTITFPGFLKAYVESI
Rv3646c|M.tuberculosis_H37Rv RGMTLSLRITGMS----------GHQEVVFSATGRTLTFPGFLKAYVETV
Mb3670c|M.bovis_AF2122/97 RGMTLSLRITGMS----------GHQEVVFSATGRTLTFPGFLKAYVETV
MLBr_00200|M.leprae_Br4923 RGTTLSLRIEGRA----------GEQHVVFSASGRTLTFPGFLKAYVETV
MMAR_5138|M.marinum_M RGTTLSLRIGGSA----------GEQQVVFSASGRTLTFPGFLKAYVETV
MUL_4222|M.ulcerans_Agy99 RGTTLSLWIGGSA----------GEQQVVFSASGRTLTFPGFLKAYVETV
MAV_0519|M.avium_104 RGTTLSLRIGGQA----------GDRQVVFSASGRTITFPGFLKAYVETV
MAB_0489|M.abscessus_ATCC_1997 RGTTLSLRLAGTAT---------SGEQVVFTASGRTITFPGFLSAYVETV
** **** : * : . .***.*:***:**.***.****::
Mflv_1394|M.gilvum_PYR-GCK DEQAGGEADDAESRLPNLTQGQRVDAKDLTADGHTTSPPARYTEASLIKA
Mvan_5396|M.vanbaalenii_PYR-1 DDLAGGEADDAESRLPNLTQGQRVDAKGLTADGHTTSPPARYTEASLIKA
MSMEG_6157|M.smegmatis_MC2_155 DELAGGESDDAESRLPNLTQGQRVDAADLSADGHQTSPPARYTEASLIKA
TH_0857|M.thermoresistible__bu DELAGGESDDAERRLPNLTEGQRVDAVDLTADGHQTNPPPRYTEASLVKA
Rv3646c|M.tuberculosis_H37Rv DELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKA
Mb3670c|M.bovis_AF2122/97 DELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKA
MLBr_00200|M.leprae_Br4923 DELAGGEADDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTEASLVKA
MMAR_5138|M.marinum_M DELVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKA
MUL_4222|M.ulcerans_Agy99 DELVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPLARYTEASLVKA
MAV_0519|M.avium_104 DELAGGEADDAESRLPQLTQGQRLDAIELTPDGHATNPPPRYTEASLVKA
MAB_0489|M.abscessus_ATCC_1997 DELSGGEADDEERRLPQLRQGQSVTVAELSADGHTTNPPARYTEASLIKA
*: ***:** * ***:* ** : *:.*** *.* .*******:**
Mflv_1394|M.gilvum_PYR-GCK LEDLGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVIGLLEQHFS
Mvan_5396|M.vanbaalenii_PYR-1 LEDLGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVIGLLEQHFG
MSMEG_6157|M.smegmatis_MC2_155 LEELGIGRPSTYSSIIKTIQDRGYVQKKGSALVPSWVAFAVVGLLEQHFG
TH_0857|M.thermoresistible__bu LEELGIGRPSTYASIIKTIQDRGYVHKRGSALVPSWVAFAVTGLLEQHFS
Rv3646c|M.tuberculosis_H37Rv LEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG
Mb3670c|M.bovis_AF2122/97 LEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG
MLBr_00200|M.leprae_Br4923 LEELGIGRPSTYSSIIKTVQDRGYVQKKGSALVPSWVAFAVTGLLEQHFG
MMAR_5138|M.marinum_M FEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG
MUL_4222|M.ulcerans_Agy99 FEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG
MAV_0519|M.avium_104 LEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG
MAB_0489|M.abscessus_ATCC_1997 LEELGIGRPSTYSSIIRTIQDRGYVHKRGSALVPSWTAFAVIGLLEQHFG
:*:*********:.**:*:******:*:********.**** *******.
Mflv_1394|M.gilvum_PYR-GCK RLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGEHGVEGSIAREGGL
Mvan_5396|M.vanbaalenii_PYR-1 RLVDYDFTAAMEDELDEIAAGHERRTNWLNNFYFGGEHGADGSIARSGGL
MSMEG_6157|M.smegmatis_MC2_155 RLVDYDFTAAMEDELDEIANGQEQRTNWLNNFYFGGEHGVEGSIARAGGL
TH_0857|M.thermoresistible__bu RLVDYDFTAAMEDELDEIAAGNEQRTNWLHNFYFGGEHGVEGSIARAGGL
Rv3646c|M.tuberculosis_H37Rv RLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGL
Mb3670c|M.bovis_AF2122/97 RLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGL
MLBr_00200|M.leprae_Br4923 RLVDYDFTAAMEDELDEIANGNEQRTNWLNNFYFGGNHGVSDSIARSGGL
MMAR_5138|M.marinum_M HLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVARAGGL
MUL_4222|M.ulcerans_Agy99 HLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVARAGGL
MAV_0519|M.avium_104 RLVDYDFTAAMEDELDAIASGQERRTDWLNNFYFGGEHGVADSIARSGGL
MAB_0489|M.abscessus_ATCC_1997 RLVDYDFTAAMEDDLDEIASGNERRTNWLNAFYFGGDHGVEGSVARAGGL
:****.*******:** ** *:*:**:**: *****:**. .*:** ***
Mflv_1394|M.gilvum_PYR-GCK KKLVGGNLEEIDAREVNSIKLFDDSEGRAVNVRVGRNGAYLERMVADPDN
Mvan_5396|M.vanbaalenii_PYR-1 KKLVGGNLEEIDAREVNSIKLFDDAEGRAVNVRVGRNGAYLERMVADPDN
MSMEG_6157|M.smegmatis_MC2_155 KQLVGGNLEGIDAREVNSIKVFDDSEGRPVYVRVGRNGPYLERMVDDPDN
TH_0857|M.thermoresistible__bu KKLVGVNLEEIDAREVNSIKLFDDDQGRPIYVRVGKNGPYLERMVIGED-
Rv3646c|M.tuberculosis_H37Rv KKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDT-
Mb3670c|M.bovis_AF2122/97 KKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDT-
MLBr_00200|M.leprae_Br4923 KKLVGVNIEGIDAREVNSIKLFDDEHGRPVYVRVGKTGPYLERLLAGDD-
MMAR_5138|M.marinum_M KKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGED-
MUL_4222|M.ulcerans_Agy99 KKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGED-
MAV_0519|M.avium_104 KKLVGVNLEGIDAREVNSIKLFDDEQGRPVYVRVGKNGPYLERMVTGDD-
MAB_0489|M.abscessus_ATCC_1997 KRLVGVNLEEIDAREINSIKLFDDDQGRPIYVRVGKNGPYLERMVADPDG
*:*** *:* *****:****:*** .**.: ****:.*.**** : .
Mflv_1394|M.gilvum_PYR-GCK -PGELKPQRANLKDELTPDELTLELAEKLFATPQEGRSLGIDPATGHEIV
Mvan_5396|M.vanbaalenii_PYR-1 -PGELKPQRANLKDELTPDELTLELAEKLFATPQEGRSLGVDPATGHEIV
MSMEG_6157|M.smegmatis_MC2_155 -PGEQKPQRANLKEDLTPDELTPELAEKLFATPQEGRSLGIDPETGHEIV
TH_0857|M.thermoresistible__bu --GEPTPQRANLKEALTPDELTLDLAEKLFATPQEGRSLGIDPETGHEIV
Rv3646c|M.tuberculosis_H37Rv --GEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIV
Mb3670c|M.bovis_AF2122/97 --GEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIV
MLBr_00200|M.leprae_Br4923 --GELTPQRANLNGTLTPDELTLEVAEELFATPHEGRVLGVDPETGHEIV
MMAR_5138|M.marinum_M --GEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIV
MUL_4222|M.ulcerans_Agy99 --GEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDAESGHEIV
MAV_0519|M.avium_104 --GEPTPQRANLNDSLTPDELTLEVAEQLFATPQEGRVLGVDPATGHEIV
MAB_0489|M.abscessus_ATCC_1997 EAGALIPQRANVKDGVTPDELTVEMAEQLFAIPQEGRTLGVDPETGHEIV
* *****:. :****** :**:*** *::** **:*. :*****
Mflv_1394|M.gilvum_PYR-GCK AKDGRYGPYVTEVLPEPPD---DGEAGATAKKGKK------PTGPKPRTG
Mvan_5396|M.vanbaalenii_PYR-1 AKDGRYGPYVTEVLPEPPD---EGEAGATAKKGKK------PTGPKPRTG
MSMEG_6157|M.smegmatis_MC2_155 AKDGRFGPYVTEVLPEPEDGGDDGTAGTPAKKGKK------PTGPKPRTG
TH_0857|M.thermoresistible__bu VKDGRYGPYVTEILPEPDDGGDDGSAGSPAKKGRK------PTGPKPRTA
Rv3646c|M.tuberculosis_H37Rv AREGRFGPYVTEILPEPA--ADAAAAAQGVKKRQK------AAGPKPRTG
Mb3670c|M.bovis_AF2122/97 AREGRFGPYVTEILPEPA--ADAAAAAQGVKKRQK------AAGPKPRTG
MLBr_00200|M.leprae_Br4923 AKDGRYGPYVTEVLPKHD--DDYGAADQGTKKTKKGRRASASQGPKPRTG
MMAR_5138|M.marinum_M AKDGRYGPYVTEILPEPP--APEAGTEAPAKKTKK------ATGPKPRSG
MUL_4222|M.ulcerans_Agy99 AKDGRYGPYVTEILPEPP--APEAGTEAPAKKSKK------ATAPKPRSG
MAV_0519|M.avium_104 AKDGRYGPYVAEVLPEPPP-DDDDGSGAPAKKGKK------PTGPKPRTA
MAB_0489|M.abscessus_ATCC_1997 AKDGRFGPYVTEVLPAPP---EPVEAEKPKRGAKK------VEGPKPRTG
.::**:****:*:** : : :* .****:.
Mflv_1394|M.gilvum_PYR-GCK SLLRSMDLETVTLDDALRLLSLPRVVGVDPANGEEITAQNGRYGPYLKRG
Mvan_5396|M.vanbaalenii_PYR-1 SLLRSMDLETVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRG
MSMEG_6157|M.smegmatis_MC2_155 SLFRSMDLETVTLEDALKLLSLPRVVGVDPTTNEEITAQNGRYGPYLKRG
TH_0857|M.thermoresistible__bu SLLRSMDIETVTLDDALKLLSLPRVVGVDPNTGEEITAQNGRYGPYLKRG
Rv3646c|M.tuberculosis_H37Rv SLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRG
Mb3670c|M.bovis_AF2122/97 SLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRG
MLBr_00200|M.leprae_Br4923 SLLRSMDLQTITLEDALKLLLLPRVVGVDPASGEEITAQNGRYGPYLKRG
MMAR_5138|M.marinum_M SLLRSMDLQTITLEDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRG
MUL_4222|M.ulcerans_Agy99 SLLRSMDLQTITLEDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRG
MAV_0519|M.avium_104 SLLRTMDLQTVTLEDALRLLSLPRVVGVDPETGEEITAQNGRYGPYLKRG
MAB_0489|M.abscessus_ATCC_1997 SLLKSMTLETVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRG
**:::* ::*:**:***:** ******.** ..*****************
Mflv_1394|M.gilvum_PYR-GCK TDSRSLATEEQMFDITLEEALKIYAEPKRRGRQGAATPPLRELGVDPVSE
Mvan_5396|M.vanbaalenii_PYR-1 TDSRSLATEEQMFDITLEEALKIYAEPKRRGRQGAATPPLRELGVDPVSE
MSMEG_6157|M.smegmatis_MC2_155 TDSRSLATEDQIFTITLDEALKIYAEPKRRGRQAASAPPLRELGNDPVSG
TH_0857|M.thermoresistible__bu SDSRSLASEEQLFTITLDEALKIYAEPKRRGRQAAAAPPLRELGEDPATG
Rv3646c|M.tuberculosis_H37Rv NDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASG
Mb3670c|M.bovis_AF2122/97 NDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASG
MLBr_00200|M.leprae_Br4923 KDSRPLTTEDQMFIITLDEALKIYAEPKRAGRQSTSPPPLRELGTDPTSG
MMAR_5138|M.marinum_M TDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASG
MUL_4222|M.ulcerans_Agy99 TDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASG
MAV_0519|M.avium_104 NDSRSLATEEQLFDITLEEALKIYAEPKRRGRQGAAAPPLRELGADPATG
MAB_0489|M.abscessus_ATCC_1997 TDSRSLATEGQIFTVTLDEALKIYSEPKRRGGQAASAAPLRELGVDSATG
.***.*.:* *:* :**:******:**** * *.::..****** *..:
Mflv_1394|M.gilvum_PYR-GCK KPMVIKDGRFGPYVTDGETNASLRKGDDVMSITDARASELLADRRARGPV
Mvan_5396|M.vanbaalenii_PYR-1 KPMVIKDGRFGPYVTDGETNASLRKGDDVLSITDARASELLADRRARGPV
MSMEG_6157|M.smegmatis_MC2_155 KPMVIKDGRFGPYVTDGETNASLRKGDDVLTITDERASELLADRRARGPV
TH_0857|M.thermoresistible__bu KPIVVKDGRFGPYVTDGETNASLRKGDDVETLTVERASELLADRRARGPV
Rv3646c|M.tuberculosis_H37Rv KPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPA
Mb3670c|M.bovis_AF2122/97 KPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPA
MLBr_00200|M.leprae_Br4923 KPMLIKDGRFGPYVTDGETNASLRKGDDVVSITDERAAELLADRRARGPV
MMAR_5138|M.marinum_M KPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPV
MUL_4222|M.ulcerans_Agy99 KAMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPV
MAV_0519|M.avium_104 KPMVIKDGRFGPYVTDGETNASLRKGDDVMSLTDQRAAELLADRRARGPA
MAB_0489|M.abscessus_ATCC_1997 KPMVIKDGRFGPYVTDGETNASLRKGDDVLSITDERASELLADRRARGPV
*.:::**********************:* ::* **:***********.
Mflv_1394|M.gilvum_PYR-GCK K---KKAAKKAAVKKTAAKKAAKKAPAKKAAKKA-
Mvan_5396|M.vanbaalenii_PYR-1 K---KKAVKKAPAKKTPAKKTAAKKAAKKA-----
MSMEG_6157|M.smegmatis_MC2_155 K---KKAPAKKAAKKAPAKKAAAKKA---------
TH_0857|M.thermoresistible__bu KRAKKTAAKKTAAKKTAAKKTAAKKTAAKKAAKKS
Rv3646c|M.tuberculosis_H37Rv KR-----PARKAARKVPAKKAAKRD----------
Mb3670c|M.bovis_AF2122/97 KR-----PARKAARKVPAKKAAKRD----------
MLBr_00200|M.leprae_Br4923 KR-----PAKK-ARKVPAKKAARLAPARGISQSPR
MMAR_5138|M.marinum_M KR-----AAKKTTRKSPAKKAVKRA----------
MUL_4222|M.ulcerans_Agy99 KR-----AAKKTTRKSPAKKAVKRA----------
MAV_0519|M.avium_104 KR-----TAKKTSRKAPAKKAAKRG----------
MAB_0489|M.abscessus_ATCC_1997 KR--AKKAPAKAAKKAPAKKAPAKKAAKKAT----
* :* .***: