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ADPKTKGPGSRSSGGNGSGRRLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPW ARLGVNVDADFEPLYIISPEKKSAVSELKDLLKDVDELYLATDGDREGEAIAWHLLETLKPRVPVKRMVF HEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRMIVQRER DRMAFRRASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAA ALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDST TLSESAINAARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYE LIWQRTVASQMADARGTTLSLWIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLP NLTPGQRLDAVELTPDGHTTNPLARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSW VAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVARAGGLKKLVGV NLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEEL FATPQEGRVLGIDAESGHEIVAKDGRYGPYVTEILPEPPAPEAGTEAPAKKSKKATAPKPRSGSLLRSMD LQTITLEDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEP KRSGRQSASAPPLRELGTDAASGKAMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRAR GPVKRAAKKTTRKSPAKKAVKRA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4222 | topA | - | 100% (934) | DNA topoisomerase I |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3670c | topA | 0.0 | 86.65% (936) | DNA topoisomerase I |
| M. gilvum PYR-GCK | Mflv_1394 | - | 0.0 | 80.32% (940) | DNA topoisomerase I |
| M. tuberculosis H37Rv | Rv3646c | topA | 0.0 | 86.65% (936) | DNA topoisomerase I |
| M. leprae Br4923 | MLBr_00200 | topA | 0.0 | 83.14% (937) | DNA topoisomerase I |
| M. abscessus ATCC 19977 | MAB_0489 | - | 0.0 | 79.02% (920) | DNA topoisomerase I |
| M. marinum M | MMAR_5138 | topA | 0.0 | 99.25% (934) | DNA topoisomerase I TopA |
| M. avium 104 | MAV_0519 | topA | 0.0 | 87.90% (934) | DNA topoisomerase I |
| M. smegmatis MC2 155 | MSMEG_6157 | topA | 0.0 | 81.74% (931) | DNA topoisomerase I |
| M. thermoresistible (build 8) | TH_0857 | topA | 0.0 | 80.54% (925) | DNA TOPOISOMERASE I TOPA (OMEGA-PROTEIN) (RELAXING ENZYME) |
| M. vanbaalenii PYR-1 | Mvan_5396 | - | 0.0 | 80.02% (941) | DNA topoisomerase I |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1394|M.gilvum_PYR-GCK MADGD---RGS---GKNGS---------VRRLVIVESPTKARKIAGYLGS
Mvan_5396|M.vanbaalenii_PYR-1 MADEE---RGS---GKNGAEPRRGNGSSVRRLVIVESPTKARKIAGYLGS
MSMEG_6157|M.smegmatis_MC2_155 MAGGD---RGS---GGTGN---------VRRLVIVESPTKARKIAGYLGS
TH_0857|M.thermoresistible__bu LAEQD---RGS---GRNGS---------VRRLVIVESPTKARKIAGYLGS
MUL_4222|M.ulcerans_Agy99 MADPKTKGPGSRSSGGNGS---------GRRLVIVESPTKARKLAGYLGP
MMAR_5138|M.marinum_M MADPKTKGPGSRSSGGNGS---------GRRLVIVESPTKARKLAGYLGP
Mb3670c|M.bovis_AF2122/97 MADPKTKGRGS---GGNGS---------GRRLVIVESPTKARKLASYLGS
Rv3646c|M.tuberculosis_H37Rv MADPKTKGRGS---GGNGS---------GRRLVIVESPTKARKLASYLGS
MLBr_00200|M.leprae_Br4923 MKGPR--GSRS---GRNGS---------PRRLVIVESPTKARKLSGYLGS
MAV_0519|M.avium_104 MADPKLKENTS---GGNGS---------RRRLVIVESPTKARKLASYLGS
MAB_0489|M.abscessus_ATCC_1997 ----------------------------MRRLVIVESPTKARKIAGYLGD
**************::.***
Mflv_1394|M.gilvum_PYR-GCK NYVVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADFEPLYIISPD
Mvan_5396|M.vanbaalenii_PYR-1 NYIVESSRGHIRDLPRNAADVPAKYKSEPWARLGVNVEHNFEPLYIISPD
MSMEG_6157|M.smegmatis_MC2_155 NYVVESSRGHIRDLPRNAADVPAKFKSEPWARLGVNVDQNFEPLYIVSPE
TH_0857|M.thermoresistible__bu DYIVESSRGHIRDLPRNAADVPAKYKSEPWARLGVDVDNDFQPLYIISPD
MUL_4222|M.ulcerans_Agy99 RYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADFEPLYIISPE
MMAR_5138|M.marinum_M RYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADFEPLYIISPE
Mb3670c|M.bovis_AF2122/97 GYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPE
Rv3646c|M.tuberculosis_H37Rv GYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPE
MLBr_00200|M.leprae_Br4923 AYIVESSRGHIRDLPRTAADVPAKFKSEPWARLGVNVDADFEPLYIITPE
MAV_0519|M.avium_104 RYIVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADFEPLYIISPE
MAB_0489|M.abscessus_ATCC_1997 GYVVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADFEPLYIVSPD
*:************* *:*****:**:*******:*: :*:****::*:
Mflv_1394|M.gilvum_PYR-GCK KKATVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVF
Mvan_5396|M.vanbaalenii_PYR-1 KKSTVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVF
MSMEG_6157|M.smegmatis_MC2_155 KKSTVTELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPRVPVKRMVF
TH_0857|M.thermoresistible__bu KKSTVTELKNKLKEADELYLATDGDREGEAIAWHLLETLKPKVPVKRMVF
MUL_4222|M.ulcerans_Agy99 KKSAVSELKDLLKDVDELYLATDGDREGEAIAWHLLETLKPRVPVKRMVF
MMAR_5138|M.marinum_M KKSAVSELKDLLKDVDELYLATDGDREGEAIAWHLLETLKPRVPVKRMVF
Mb3670c|M.bovis_AF2122/97 KRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVF
Rv3646c|M.tuberculosis_H37Rv KRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVF
MLBr_00200|M.leprae_Br4923 KKSTVTELKGLLQGVDELYLATDGDREGEAIAWHLMQTLKPRVPVKRMVF
MAV_0519|M.avium_104 KKHTVSELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPNIPVKRMVF
MAB_0489|M.abscessus_ATCC_1997 KKGTVTELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPKVPVRRMVF
*: :*::*:. *: .********************::****.:**:****
Mflv_1394|M.gilvum_PYR-GCK HEITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAP
Mvan_5396|M.vanbaalenii_PYR-1 HEITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAP
MSMEG_6157|M.smegmatis_MC2_155 HEITEPAIRNAAENPRDLDIALVDAQETRRILDRLYGYEVSPVLWKKVAP
TH_0857|M.thermoresistible__bu HEITESAIRNAAENPRDLDTALVDAQETRRILDRLYGYEVSPVLWKKVAP
MUL_4222|M.ulcerans_Agy99 HEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAP
MMAR_5138|M.marinum_M HEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAP
Mb3670c|M.bovis_AF2122/97 HEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAP
Rv3646c|M.tuberculosis_H37Rv HEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAP
MLBr_00200|M.leprae_Br4923 HEITEHAILAAAAHPRELDIDLVDAQETRRILDRLYGYEVSPVLWKKVAP
MAV_0519|M.avium_104 HEITEPAILEAAENPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAP
MAB_0489|M.abscessus_ATCC_1997 HEITEQAILAAAQDPRDLDNNLVDAQETRRILDRLYGYEVSPVLWKKVGR
***** ** ** .**:** ***************************.
Mflv_1394|M.gilvum_PYR-GCK KLSAGRVQSVATRIIVQRERERMAFRSAGYWDVTAELDASVSDAQATPPT
Mvan_5396|M.vanbaalenii_PYR-1 KLSAGRVQSVATRIIVQRERERMAFRSAGYWDVTAELDASVSDAQASPPT
MSMEG_6157|M.smegmatis_MC2_155 KLSAGRVQSVATRIIVQRERERMAFHSASYWDVTAELDASVSDPSASPPK
TH_0857|M.thermoresistible__bu KLSAGRVQSVATRIIVQRERERMAFRSASYWDVTAQLDASVSDPQASPPV
MUL_4222|M.ulcerans_Agy99 KLSAGRVQSVATRMIVQRERDRMAFRRASYWDIVATLDASVSDPKAAPPT
MMAR_5138|M.marinum_M KLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPT
Mb3670c|M.bovis_AF2122/97 KLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPT
Rv3646c|M.tuberculosis_H37Rv KLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPT
MLBr_00200|M.leprae_Br4923 KLSAGRVQSVATRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTAQPLT
MAV_0519|M.avium_104 KLSAGRVQSVATRIIVQRERDRMAFRSASYWDIVAQLDASVSDPQASPPT
MAB_0489|M.abscessus_ATCC_1997 NLSAGRVQSVATRIIVQRERDRMAFRSAGYWDLGAELDAGKDNPAAKPPR
:************:** ***:**** * ***: * ***. .:. * *
Mflv_1394|M.gilvum_PYR-GCK FVAKLNTVDGRRVAAGRDFDSLGAVK---KPGEVLVLDEAAANALAGGLR
Mvan_5396|M.vanbaalenii_PYR-1 FVAKLNTVDGRRVATGRDFDSLGAVR---KPDEVLVLDEAAANALATGLR
MSMEG_6157|M.smegmatis_MC2_155 FTAKLNTVDGRRVATGRDFDSLGQLK---RPDEVLVLDEASAGALASGLR
TH_0857|M.thermoresistible__bu FAAKLSTVDGRRVATGRDFDSRGVVK---KPDEVLVLDESDANALVAGLR
MUL_4222|M.ulcerans_Agy99 FVARLTSVDGLRVATGRDFDSLGTLR---KADEVTVLDEARAAALATGLH
MMAR_5138|M.marinum_M FVARLTSVDGLRVATGRDFDSLGTLR---KADEVTVLDEARAAALATGLH
Mb3670c|M.bovis_AF2122/97 FSARLTAVAGRRVATGRDFDSLGTLR---KGDEVIVLDEGSATALAAGLD
Rv3646c|M.tuberculosis_H37Rv FSARLTAVAGRRVATGRDFDSLGTLR---KGDEVIVLDEGSATALAAGLD
MLBr_00200|M.leprae_Br4923 FVARLTAVDGLRVATGRDFGAMGTLRGDCEVSKIIVLDDLTATTLAAGLR
MAV_0519|M.avium_104 FAARLTSVDGLRVATGRDFDSQGQLR---KADEVIVLDEPQATELAAGLQ
MAB_0489|M.abscessus_ATCC_1997 FHARLVSVDALRVASGRDFDSLGQVKETSNGPGVLVLDETRANALVAGLS
* *:* :* . ***:****.: * :: . : ***: * *. **
Mflv_1394|M.gilvum_PYR-GCK GAQLSVSSVEQKPYTRRPYAPFMTSTLQQEAGRKLRMSSERTMSIAQRLY
Mvan_5396|M.vanbaalenii_PYR-1 GAQLAVSSVEQKPYTRRPYAPFMTSTLQQEAGRKLRFTSERTMSIAQRLY
MSMEG_6157|M.smegmatis_MC2_155 GAQLAVTSVEQKPYTRRPYAPFMTSTLQQEAARKLRFSSERTMSIAQRLY
TH_0857|M.thermoresistible__bu NVQLTVTSVEQKPYTRRPYAPFMTSTLQQEAGRKLRFSAERTMSIAQRLY
MUL_4222|M.ulcerans_Agy99 GAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLY
MMAR_5138|M.marinum_M GAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLY
Mb3670c|M.bovis_AF2122/97 GTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLY
Rv3646c|M.tuberculosis_H37Rv GTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLY
MLBr_00200|M.leprae_Br4923 GAQLTVASAEEKLYTRRPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLY
MAV_0519|M.avium_104 GAQLSVASVEEKPYTRRPYAPFMTSTLQQEAGRKLRFSAERTMSIAQRLY
MAB_0489|M.abscessus_ATCC_1997 QATLTVVSAEEKPYTRKPYPPFMTSTLQQEAGRKLRFSSERTMSIAQRLY
. *:* *.*:* *:*:**.***********.****::.***********
Mflv_1394|M.gilvum_PYR-GCK ENGYITYMRTDSTTLSQSAIDAARNQARQLYGEEYVHPTPRQYTRKVKNA
Mvan_5396|M.vanbaalenii_PYR-1 ENGYITYMRTDSTTLSQSAIDAARNQARQLYGEEYVHPTPRQYTRKVKNA
MSMEG_6157|M.smegmatis_MC2_155 ENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVHPSPRQYTRKVKNA
TH_0857|M.thermoresistible__bu ENGYITYMRTDSITLSQSAINAARNQARQLYGEEYVHPTPRQYSRKVKNA
MUL_4222|M.ulcerans_Agy99 ENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYTRKVKNA
MMAR_5138|M.marinum_M ENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYTRKVKNA
Mb3670c|M.bovis_AF2122/97 ENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNA
Rv3646c|M.tuberculosis_H37Rv ENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNA
MLBr_00200|M.leprae_Br4923 ENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVSDSPRQYTRKVKNA
MAV_0519|M.avium_104 ENGYITYMRTDSTTLSGSAINAARTQARQLYGEEYVSPSPRQYTRKVKNA
MAB_0489|M.abscessus_ATCC_1997 ENGYITYMRTDSTTLSDSALQAARSQAAELYGNEYVHPSPRQYTRKVKNA
************ *** **::***.** :***:*** :****:******
Mflv_1394|M.gilvum_PYR-GCK QEAHEAIRPAGDVFQTPGQLHSQLDT---DEFRLYELIWQRTVASQMADA
Mvan_5396|M.vanbaalenii_PYR-1 QEAHEAIRPAGDVFQTPGQLHSQLDT---DEFRLYELIWQRTVASQMADA
MSMEG_6157|M.smegmatis_MC2_155 QEAHEAIRPAGDVFQTPGQLHSALDT---DEFRLYELIWQRTVASQMADA
TH_0857|M.thermoresistible__bu QEAHEAIRPAGDVFATPGQLANELAP---DEFRLYELIWQRTVASQMADA
MUL_4222|M.ulcerans_Agy99 QEAHEAIRPAGETFATPDAVRRELDG---DEFRLYELIWQRTVASQMADA
MMAR_5138|M.marinum_M QEAHEAIRPAGETFATPDAVRRELDG---DEFRLYELIWQRTVASQMADA
Mb3670c|M.bovis_AF2122/97 QEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADA
Rv3646c|M.tuberculosis_H37Rv QEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADA
MLBr_00200|M.leprae_Br4923 QEAHEAIRPAGETFATPDAVCNELDG---DEFRIYELVWRRTVASQMADA
MAV_0519|M.avium_104 QEAHEAIRPAGETFATPDAVRRELDG---DEFRLYELIWQRTVASQMADA
MAB_0489|M.abscessus_ATCC_1997 QEAHEAIRPAGETFKTPGQLHSSLDN---DEFRLYELIWQRTVASQMADA
***********:.* **. : * *:**:***:*:**********
Mflv_1394|M.gilvum_PYR-GCK RGTTLSLRIAGAA---------TSGEQVVFNASGRTITFAGFLKAYVESL
Mvan_5396|M.vanbaalenii_PYR-1 RGTTLSLRIAGAAPATTLGGGTASDVQVVFNASGRTITFPGFLKAYVESI
MSMEG_6157|M.smegmatis_MC2_155 RGTTLSLRIGGSA---------SSGEQVVFNASGRTITFPGFLKAYVESI
TH_0857|M.thermoresistible__bu RGTTLSLRISGTT---------ADGRQVVFTASGRTITFPGFLKAYVESI
MUL_4222|M.ulcerans_Agy99 RGTTLSLWIGGSA----------GEQQVVFSASGRTLTFPGFLKAYVETV
MMAR_5138|M.marinum_M RGTTLSLRIGGSA----------GEQQVVFSASGRTLTFPGFLKAYVETV
Mb3670c|M.bovis_AF2122/97 RGMTLSLRITGMS----------GHQEVVFSATGRTLTFPGFLKAYVETV
Rv3646c|M.tuberculosis_H37Rv RGMTLSLRITGMS----------GHQEVVFSATGRTLTFPGFLKAYVETV
MLBr_00200|M.leprae_Br4923 RGTTLSLRIEGRA----------GEQHVVFSASGRTLTFPGFLKAYVETV
MAV_0519|M.avium_104 RGTTLSLRIGGQA----------GDRQVVFSASGRTITFPGFLKAYVETV
MAB_0489|M.abscessus_ATCC_1997 RGTTLSLRLAGTAT---------SGEQVVFTASGRTITFPGFLSAYVETV
** **** : * : . .***.*:***:**.***.****::
Mflv_1394|M.gilvum_PYR-GCK DEQAGGEADDAESRLPNLTQGQRVDAKDLTADGHTTSPPARYTEASLIKA
Mvan_5396|M.vanbaalenii_PYR-1 DDLAGGEADDAESRLPNLTQGQRVDAKGLTADGHTTSPPARYTEASLIKA
MSMEG_6157|M.smegmatis_MC2_155 DELAGGESDDAESRLPNLTQGQRVDAADLSADGHQTSPPARYTEASLIKA
TH_0857|M.thermoresistible__bu DELAGGESDDAERRLPNLTEGQRVDAVDLTADGHQTNPPPRYTEASLVKA
MUL_4222|M.ulcerans_Agy99 DELVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPLARYTEASLVKA
MMAR_5138|M.marinum_M DELVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKA
Mb3670c|M.bovis_AF2122/97 DELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKA
Rv3646c|M.tuberculosis_H37Rv DELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKA
MLBr_00200|M.leprae_Br4923 DELAGGEADDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTEASLVKA
MAV_0519|M.avium_104 DELAGGEADDAESRLPQLTQGQRLDAIELTPDGHATNPPPRYTEASLVKA
MAB_0489|M.abscessus_ATCC_1997 DELSGGEADDEERRLPQLRQGQSVTVAELSADGHTTNPPARYTEASLIKA
*: ***:** * ***:* ** : *:.*** *.* .*******:**
Mflv_1394|M.gilvum_PYR-GCK LEDLGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVIGLLEQHFS
Mvan_5396|M.vanbaalenii_PYR-1 LEDLGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVIGLLEQHFG
MSMEG_6157|M.smegmatis_MC2_155 LEELGIGRPSTYSSIIKTIQDRGYVQKKGSALVPSWVAFAVVGLLEQHFG
TH_0857|M.thermoresistible__bu LEELGIGRPSTYASIIKTIQDRGYVHKRGSALVPSWVAFAVTGLLEQHFS
MUL_4222|M.ulcerans_Agy99 FEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG
MMAR_5138|M.marinum_M FEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG
Mb3670c|M.bovis_AF2122/97 LEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG
Rv3646c|M.tuberculosis_H37Rv LEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG
MLBr_00200|M.leprae_Br4923 LEELGIGRPSTYSSIIKTVQDRGYVQKKGSALVPSWVAFAVTGLLEQHFG
MAV_0519|M.avium_104 LEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFG
MAB_0489|M.abscessus_ATCC_1997 LEELGIGRPSTYSSIIRTIQDRGYVHKRGSALVPSWTAFAVIGLLEQHFG
:*:*********:.**:*:******:*:********.**** *******.
Mflv_1394|M.gilvum_PYR-GCK RLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGEHGVEGSIAREGGL
Mvan_5396|M.vanbaalenii_PYR-1 RLVDYDFTAAMEDELDEIAAGHERRTNWLNNFYFGGEHGADGSIARSGGL
MSMEG_6157|M.smegmatis_MC2_155 RLVDYDFTAAMEDELDEIANGQEQRTNWLNNFYFGGEHGVEGSIARAGGL
TH_0857|M.thermoresistible__bu RLVDYDFTAAMEDELDEIAAGNEQRTNWLHNFYFGGEHGVEGSIARAGGL
MUL_4222|M.ulcerans_Agy99 HLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVARAGGL
MMAR_5138|M.marinum_M HLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVARAGGL
Mb3670c|M.bovis_AF2122/97 RLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGL
Rv3646c|M.tuberculosis_H37Rv RLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGL
MLBr_00200|M.leprae_Br4923 RLVDYDFTAAMEDELDEIANGNEQRTNWLNNFYFGGNHGVSDSIARSGGL
MAV_0519|M.avium_104 RLVDYDFTAAMEDELDAIASGQERRTDWLNNFYFGGEHGVADSIARSGGL
MAB_0489|M.abscessus_ATCC_1997 RLVDYDFTAAMEDDLDEIASGNERRTNWLNAFYFGGDHGVEGSVARAGGL
:****.*******:** ** *:*:**:**: *****:**. .*:** ***
Mflv_1394|M.gilvum_PYR-GCK KKLVGGNLEEIDAREVNSIKLFDDSEGRAVNVRVGRNGAYLERMVADPDN
Mvan_5396|M.vanbaalenii_PYR-1 KKLVGGNLEEIDAREVNSIKLFDDAEGRAVNVRVGRNGAYLERMVADPDN
MSMEG_6157|M.smegmatis_MC2_155 KQLVGGNLEGIDAREVNSIKVFDDSEGRPVYVRVGRNGPYLERMVDDPDN
TH_0857|M.thermoresistible__bu KKLVGVNLEEIDAREVNSIKLFDDDQGRPIYVRVGKNGPYLERMVIGED-
MUL_4222|M.ulcerans_Agy99 KKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGED-
MMAR_5138|M.marinum_M KKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGED-
Mb3670c|M.bovis_AF2122/97 KKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDT-
Rv3646c|M.tuberculosis_H37Rv KKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDT-
MLBr_00200|M.leprae_Br4923 KKLVGVNIEGIDAREVNSIKLFDDEHGRPVYVRVGKTGPYLERLLAGDD-
MAV_0519|M.avium_104 KKLVGVNLEGIDAREVNSIKLFDDEQGRPVYVRVGKNGPYLERMVTGDD-
MAB_0489|M.abscessus_ATCC_1997 KRLVGVNLEEIDAREINSIKLFDDDQGRPIYVRVGKNGPYLERMVADPDG
*:*** *:* *****:****:*** .**.: ****:.*.**** : .
Mflv_1394|M.gilvum_PYR-GCK -PGELKPQRANLKDELTPDELTLELAEKLFATPQEGRSLGIDPATGHEIV
Mvan_5396|M.vanbaalenii_PYR-1 -PGELKPQRANLKDELTPDELTLELAEKLFATPQEGRSLGVDPATGHEIV
MSMEG_6157|M.smegmatis_MC2_155 -PGEQKPQRANLKEDLTPDELTPELAEKLFATPQEGRSLGIDPETGHEIV
TH_0857|M.thermoresistible__bu --GEPTPQRANLKEALTPDELTLDLAEKLFATPQEGRSLGIDPETGHEIV
MUL_4222|M.ulcerans_Agy99 --GEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDAESGHEIV
MMAR_5138|M.marinum_M --GEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIV
Mb3670c|M.bovis_AF2122/97 --GEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIV
Rv3646c|M.tuberculosis_H37Rv --GEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIV
MLBr_00200|M.leprae_Br4923 --GELTPQRANLNGTLTPDELTLEVAEELFATPHEGRVLGVDPETGHEIV
MAV_0519|M.avium_104 --GEPTPQRANLNDSLTPDELTLEVAEQLFATPQEGRVLGVDPATGHEIV
MAB_0489|M.abscessus_ATCC_1997 EAGALIPQRANVKDGVTPDELTVEMAEQLFAIPQEGRTLGVDPETGHEIV
* *****:. :****** :**:*** *::** **:*. :*****
Mflv_1394|M.gilvum_PYR-GCK AKDGRYGPYVTEVLPEPPD---DGEAGATAKKGKK------PTGPKPRTG
Mvan_5396|M.vanbaalenii_PYR-1 AKDGRYGPYVTEVLPEPPD---EGEAGATAKKGKK------PTGPKPRTG
MSMEG_6157|M.smegmatis_MC2_155 AKDGRFGPYVTEVLPEPEDGGDDGTAGTPAKKGKK------PTGPKPRTG
TH_0857|M.thermoresistible__bu VKDGRYGPYVTEILPEPDDGGDDGSAGSPAKKGRK------PTGPKPRTA
MUL_4222|M.ulcerans_Agy99 AKDGRYGPYVTEILPEPP--APEAGTEAPAKKSKK------ATAPKPRSG
MMAR_5138|M.marinum_M AKDGRYGPYVTEILPEPP--APEAGTEAPAKKTKK------ATGPKPRSG
Mb3670c|M.bovis_AF2122/97 AREGRFGPYVTEILPEPA--ADAAAAAQGVKKRQK------AAGPKPRTG
Rv3646c|M.tuberculosis_H37Rv AREGRFGPYVTEILPEPA--ADAAAAAQGVKKRQK------AAGPKPRTG
MLBr_00200|M.leprae_Br4923 AKDGRYGPYVTEVLPKHD--DDYGAADQGTKKTKKGRRASASQGPKPRTG
MAV_0519|M.avium_104 AKDGRYGPYVAEVLPEPPP-DDDDGSGAPAKKGKK------PTGPKPRTA
MAB_0489|M.abscessus_ATCC_1997 AKDGRFGPYVTEVLPAPP---EPVEAEKPKRGAKK------VEGPKPRTG
.::**:****:*:** : : :* .****:.
Mflv_1394|M.gilvum_PYR-GCK SLLRSMDLETVTLDDALRLLSLPRVVGVDPANGEEITAQNGRYGPYLKRG
Mvan_5396|M.vanbaalenii_PYR-1 SLLRSMDLETVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRG
MSMEG_6157|M.smegmatis_MC2_155 SLFRSMDLETVTLEDALKLLSLPRVVGVDPTTNEEITAQNGRYGPYLKRG
TH_0857|M.thermoresistible__bu SLLRSMDIETVTLDDALKLLSLPRVVGVDPNTGEEITAQNGRYGPYLKRG
MUL_4222|M.ulcerans_Agy99 SLLRSMDLQTITLEDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRG
MMAR_5138|M.marinum_M SLLRSMDLQTITLEDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRG
Mb3670c|M.bovis_AF2122/97 SLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRG
Rv3646c|M.tuberculosis_H37Rv SLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRG
MLBr_00200|M.leprae_Br4923 SLLRSMDLQTITLEDALKLLLLPRVVGVDPASGEEITAQNGRYGPYLKRG
MAV_0519|M.avium_104 SLLRTMDLQTVTLEDALRLLSLPRVVGVDPETGEEITAQNGRYGPYLKRG
MAB_0489|M.abscessus_ATCC_1997 SLLKSMTLETVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRG
**:::* ::*:**:***:** ******.** ..*****************
Mflv_1394|M.gilvum_PYR-GCK TDSRSLATEEQMFDITLEEALKIYAEPKRRGRQGAATPPLRELGVDPVSE
Mvan_5396|M.vanbaalenii_PYR-1 TDSRSLATEEQMFDITLEEALKIYAEPKRRGRQGAATPPLRELGVDPVSE
MSMEG_6157|M.smegmatis_MC2_155 TDSRSLATEDQIFTITLDEALKIYAEPKRRGRQAASAPPLRELGNDPVSG
TH_0857|M.thermoresistible__bu SDSRSLASEEQLFTITLDEALKIYAEPKRRGRQAAAAPPLRELGEDPATG
MUL_4222|M.ulcerans_Agy99 TDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASG
MMAR_5138|M.marinum_M TDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASG
Mb3670c|M.bovis_AF2122/97 NDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASG
Rv3646c|M.tuberculosis_H37Rv NDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASG
MLBr_00200|M.leprae_Br4923 KDSRPLTTEDQMFIITLDEALKIYAEPKRAGRQSTSPPPLRELGTDPTSG
MAV_0519|M.avium_104 NDSRSLATEEQLFDITLEEALKIYAEPKRRGRQGAAAPPLRELGADPATG
MAB_0489|M.abscessus_ATCC_1997 TDSRSLATEGQIFTVTLDEALKIYSEPKRRGGQAASAAPLRELGVDSATG
.***.*.:* *:* :**:******:**** * *.::..****** *..:
Mflv_1394|M.gilvum_PYR-GCK KPMVIKDGRFGPYVTDGETNASLRKGDDVMSITDARASELLADRRARGPV
Mvan_5396|M.vanbaalenii_PYR-1 KPMVIKDGRFGPYVTDGETNASLRKGDDVLSITDARASELLADRRARGPV
MSMEG_6157|M.smegmatis_MC2_155 KPMVIKDGRFGPYVTDGETNASLRKGDDVLTITDERASELLADRRARGPV
TH_0857|M.thermoresistible__bu KPIVVKDGRFGPYVTDGETNASLRKGDDVETLTVERASELLADRRARGPV
MUL_4222|M.ulcerans_Agy99 KAMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPV
MMAR_5138|M.marinum_M KPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPV
Mb3670c|M.bovis_AF2122/97 KPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPA
Rv3646c|M.tuberculosis_H37Rv KPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPA
MLBr_00200|M.leprae_Br4923 KPMLIKDGRFGPYVTDGETNASLRKGDDVVSITDERAAELLADRRARGPV
MAV_0519|M.avium_104 KPMVIKDGRFGPYVTDGETNASLRKGDDVMSLTDQRAAELLADRRARGPA
MAB_0489|M.abscessus_ATCC_1997 KPMVIKDGRFGPYVTDGETNASLRKGDDVLSITDERASELLADRRARGPV
*.:::**********************:* ::* **:***********.
Mflv_1394|M.gilvum_PYR-GCK K---KKAAKKAAVKKTAAKKAAKKAPAKKAAKKA-
Mvan_5396|M.vanbaalenii_PYR-1 K---KKAVKKAPAKKTPAKKTAAKKAAKKA-----
MSMEG_6157|M.smegmatis_MC2_155 K---KKAPAKKAAKKAPAKKAAAKKA---------
TH_0857|M.thermoresistible__bu KRAKKTAAKKTAAKKTAAKKTAAKKTAAKKAAKKS
MUL_4222|M.ulcerans_Agy99 KR-----AAKKTTRKSPAKKAVKRA----------
MMAR_5138|M.marinum_M KR-----AAKKTTRKSPAKKAVKRA----------
Mb3670c|M.bovis_AF2122/97 KR-----PARKAARKVPAKKAAKRD----------
Rv3646c|M.tuberculosis_H37Rv KR-----PARKAARKVPAKKAAKRD----------
MLBr_00200|M.leprae_Br4923 KR-----PAKK-ARKVPAKKAARLAPARGISQSPR
MAV_0519|M.avium_104 KR-----TAKKTSRKAPAKKAAKRG----------
MAB_0489|M.abscessus_ATCC_1997 KR--AKKAPAKAAKKAPAKKAPAKKAAKKAT----
* :* .***: