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AASLSENLSCHSSNMCRLSGNAATNLERPGEEPPGDRCTRRQAVRPARTLAKKGNIPVGYYKDEKKTAET FRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAALKGHPDVFDALVVGVPDPRYG QQVAAVVQARPGCRPSLAELDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHA GHVTSGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3513c | fadD18 | - | 100% (218) | PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) |
| M. tuberculosis H37Rv | Rv3515c | fadD19 | 2e-95 | 99.40% (167) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1427c | fadD12 | 2e-21 | 44.44% (108) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3542c | fadD18 | 1e-126 | 100.00% (218) | fatty-acid-CoA ligase |
| M. gilvum PYR-GCK | Mflv_1543 | - | 1e-80 | 85.37% (164) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 3e-17 | 37.04% (108) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4163c | - | 1e-65 | 68.45% (168) | acyl-CoA synthetase |
| M. marinum M | MMAR_5001 | fadD19_1 | 4e-87 | 91.57% (166) | fatty-acid-CoA ligase FadD19_1 |
| M. avium 104 | MAV_0644 | - | 2e-87 | 91.57% (166) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5914 | - | 1e-80 | 82.14% (168) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_1821 | fadD19 | 1e-77 | 79.04% (167) | PROBABLE FATTY-ACID-CoA LIGASE FADD19 (FATTY-ACID-CoA |
| M. ulcerans Agy99 | MUL_4075 | fadD19_1 | 3e-87 | 91.57% (166) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_5215 | - | 3e-81 | 85.37% (164) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3513c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3542c|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5914|M.smegmatis_MC2_155 ---------------------------------------MALN----IAD
Mvan_5215|M.vanbaalenii_PYR-1 ---------------------------------------MALN----IAD
Mflv_1543|M.gilvum_PYR-GCK ---------------------------------------MALN----IAD
TH_1821|M.thermoresistible__bu ---------------------------------------VALN----IAD
MMAR_5001|M.marinum_M -------------------------------------MAVALN----IAD
MUL_4075|M.ulcerans_Agy99 -------------------------------------MAVALN----IAD
MAV_0644|M.avium_104 -------------------------------------MAVALN----IAD
MAB_4163c|M.abscessus_ATCC_199 ---------------------------------------MALN----IAD
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
Rv3513c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3542c|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5914|M.smegmatis_MC2_155 LAEHAIDAVPDRVALISGGDQLTYGQLEEKANRFAHYLIDQGVKKDDKVG
Mvan_5215|M.vanbaalenii_PYR-1 LAEHAIDAVPDRVALISGDEQLTYAELEEKSNRLAHYLIDQGVKKDDKVG
Mflv_1543|M.gilvum_PYR-GCK LAEHAIDAVPDRVAIITGDEQLTYAQLEEKANRLAHYLLDQGVKKDDKVG
TH_1821|M.thermoresistible__bu LTEHAIDAVPDRVALICGDDQLTYAQLEEKANRLAHYLLDQGVRKDDKVG
MMAR_5001|M.marinum_M LAEHAIDAVPDRVALICGDEQLTYAQLEEKANRLAHHLIDQGVGKGDKVG
MUL_4075|M.ulcerans_Agy99 LAEHAIDAVPDRVALICGDEQLTYAQLEEKANRLAHHLIDQGVRKGDKVG
MAV_0644|M.avium_104 LAEHAIDAVPDRVALICGDEKLTYAELEEKANRLAHYLLDQGVKKDDKVG
MAB_4163c|M.abscessus_ATCC_199 LIEHAIDTMPDRVAIISGDRKLTYAELEEQSNRLGHYLQSQGVGPGDKVG
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
Rv3513c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3542c|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5914|M.smegmatis_MC2_155 LYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELKYLFENSDMVALVHE
Mvan_5215|M.vanbaalenii_PYR-1 LYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELKYLFENSDMVALVHE
Mflv_1543|M.gilvum_PYR-GCK LYCRNRNEIVIAMLGIVKAGAILVNVNFRYVEGELKYLFDNSDMVALVHE
TH_1821|M.thermoresistible__bu LYCRNRNEIVVAALACVKAGAIAVNVNFRYVEAELRYLFDNSDMVALVHE
MMAR_5001|M.marinum_M LYCRNRIEIVIAMLGIIKAGAILINVNFRYVEGELKYLFDNSDMVALVHE
MUL_4075|M.ulcerans_Agy99 LYCRNRIEIVIAMLGIIKAGAILINVNFRYVEGELKYLFDNSDMVALVHE
MAV_0644|M.avium_104 LYCRNRNEIVIAMLGIVKAGAILVNVNYRYVEGELRYLFDNSDMVALVHE
MAB_4163c|M.abscessus_ATCC_199 LYCRNGIEIVIALTAIVKIRAISVNVNYRYVEAELHYLFENSDMAALVHE
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
Rv3513c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3542c|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5914|M.smegmatis_MC2_155 RRYSDRVANVLPETPDIKTILVVEDGSDDDYERFGGVEFYSALEKSSPER
Mvan_5215|M.vanbaalenii_PYR-1 RRYADRVANVLPETPNVKTILVVEDGTDEDYQRYGGVEFYSALAQGSPER
Mflv_1543|M.gilvum_PYR-GCK RRYADRVANVLPETPKVKTILVIEDGSDDDYERYGGVEFNAALEQGSPER
TH_1821|M.thermoresistible__bu RQYSDRVANVLPETPKVKTIVVIEDGSDLDYQRYGGVEFEAALAQGSPER
MMAR_5001|M.marinum_M RQYADRVANVLPDTPNVKTILVVQDGSDKDYRRYGGVEFYSAIADSSPER
MUL_4075|M.ulcerans_Agy99 RQYADRVANVLPDTPNVKTILVVQDGSDKDYQRYGGVEFYSAIADGSPER
MAV_0644|M.avium_104 RQYSDRVANVLPDTPNVKTILVVEDGSDKDYQRYGGVEFYSALEKGSPER
MAB_4163c|M.abscessus_ATCC_199 RRYSDKVANVLPSTPNVKTAIVVEDGADGSFDSYGGVPFADALAQGSPER
MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSSSAPAP
Rv3513c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3542c|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5914|M.smegmatis_MC2_155 DFGP----RSEDDIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGE
Mvan_5215|M.vanbaalenii_PYR-1 DFGP----RSEDDIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGE
Mflv_1543|M.gilvum_PYR-GCK DFGP----RSEDDIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGE
TH_1821|M.thermoresistible__bu DFGP----RSADDIYLLYTGGTTGFPKGVMWRHEDIYRVLLGGIDFATGE
MMAR_5001|M.marinum_M DFAELQRERSADDIYILYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGE
MUL_4075|M.ulcerans_Agy99 DFAELQRERSADDIYILYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGE
MAV_0644|M.avium_104 DFGP----RSADDIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGE
MAB_4163c|M.abscessus_ATCC_199 DFEE----RSPDDIFLIYTGGTTGFPKGVMWRHEDIYRSLFGGINYVTGE
MLBr_02546|M.leprae_Br4923 KVRK-------RASIIILTSGTTGTPKGANRNTPASLAPLGG--------
Rv3513c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3542c|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_5914|M.smegmatis_MC2_155 PIEDEYGLAKQAAANPPMVRYPIPPMIHGATQSATWMALFAGGTVLLTPE
Mvan_5215|M.vanbaalenii_PYR-1 PIADEYGLAKQAVESGPMVRYPIPPMIHGATQSATWMALFSGQTTVLTPE
Mflv_1543|M.gilvum_PYR-GCK PIADEYDLSRSAVDNPPMIRLPIPPMIHGATQSATWMALFSGHTVVLTPE
TH_1821|M.thermoresistible__bu YVADEYDHARQAKENPPMVRYPIPPMIHGATQSATWMALFGGGTVVLAPE
MMAR_5001|M.marinum_M FIKDEYDLAKAAAANPPMIRYPIPPMIHGATQSATWMSIFSGQTTVLAPE
MUL_4075|M.ulcerans_Agy99 FIKDEYDLAKAAAANPPMIRYPIPPMIHGATQSATWMSIFSGQTTVLAPE
MAV_0644|M.avium_104 FVKDEYDLAKAAAENPPMIRYPIPPMIHGATQSATWMSIFSGQTTVLAPE
MAB_4163c|M.abscessus_ATCC_199 YIEGEWDLAKQGAEAAPFIGFPIPPMIHGATQAATFMALFQGRTTVLAPE
MLBr_02546|M.leprae_Br4923 -------ILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRR
Rv3513c|M.tuberculosis_H37Rv ------------------------MAASLSENLSCH--------------
Mb3542c|M.bovis_AF2122/97 ------------------------MAASLSENLSCH--------------
MSMEG_5914|M.smegmatis_MC2_155 FNPDEVWQAIHDHKVNLLFFTGDAMARPLLDSLLAAKDAGKEYDLSSLFL
Mvan_5215|M.vanbaalenii_PYR-1 FDAEAVWRTIHEHKVNLLFFTGDAMARPLLDALLAAQDAGDQYDLSSLFL
Mflv_1543|M.gilvum_PYR-GCK FDADQIWRMIHEHKVNLLFFTGDAMARPLLDALLAHQEEGNTYDLSSLFL
TH_1821|M.thermoresistible__bu FDPAEVWRTCEKHKVNLLFFTGDAMARPLVDALTAP---GANYDLSNLFL
MMAR_5001|M.marinum_M FDADQVWRTISDRKVNLLFFTGDAMARPLLDALMKD----NDYDLSSLFL
MUL_4075|M.ulcerans_Agy99 FDADQVWRTISDRKVNLLFFTGDAMARPLLDALMKD----NDYDLSSLFL
MAV_0644|M.avium_104 FNADEVWRTIHEHKVNLVFFTGDAMARPLLDALNKD----HDYDLSSLFL
MAB_4163c|M.abscessus_ATCC_199 FNPEEVWELIEKHKINMLFFAGDAIGRPLIDALDTETG--RARDLSSLWV
MLBr_02546|M.leprae_Br4923 FKPATVLEDIEKHQATAMVVVPVMLSR-ILDTLENLET---KSDLSSLRV
:. : : *
Rv3513c|M.tuberculosis_H37Rv -SSNMCRLS-------------------------GNAATNLERPGEEPPG
Mb3542c|M.bovis_AF2122/97 -SSNMCRLS-------------------------GNAATNLERPGEEPPG
MSMEG_5914|M.smegmatis_MC2_155 LASTAALFSTSLKEKFLELLPNRVITDSIGSSETGFGGTSIVAKGQSHTG
Mvan_5215|M.vanbaalenii_PYR-1 LASTAALFSTSLKEKFLELLPNRIITDSIGSSETGFGGTSIVAKGESHTG
Mflv_1543|M.gilvum_PYR-GCK LASTAALFSTSIKEKFLELLPNRIITDSIGSSETGFGGTSIVAKGESHTG
TH_1821|M.thermoresistible__bu LASTAALFSPSLKDQLLELLPNRIITDSIGSSETGFGGSSVVTKGQTHTG
MMAR_5001|M.marinum_M LASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGTSIVGAGQATTG
MUL_4075|M.ulcerans_Agy99 LASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGTSIVGAGQATTG
MAV_0644|M.avium_104 LASTAALFSPSIKERLLELLPNRVITDSIGSSETGFGGTSIVAKDAPHAG
MAB_4163c|M.abscessus_ATCC_199 LASSAALFSQTVKERYLELLPNRVITDAIGASETGTGGLSTVTKGQMHPG
MLBr_02546|M.leprae_Br4923 VFVSGSQLGAELATRALEELG-PVIYNMYGSTEIAFATIAGPKDLQINSA
. . :. . . ..
Rv3513c|M.tuberculosis_H37Rv D-RCTRRQ----------AVRPAR----TLAKKGNIPVGYYKDEKKTAET
Mb3542c|M.bovis_AF2122/97 D-RCTRRQ----------AVRPAR----TLAKKGNIPVGYYKDEKKTAET
MSMEG_5914|M.smegmatis_MC2_155 GPRVTIDKNTVVLDDDGNEVKPGSGVRGVIAKRGHIPLGYYKDEKKTAET
Mvan_5215|M.vanbaalenii_PYR-1 GPRVTIDKNTVVLDEDGNPVTPGSGVRGIIAKRGHIPVGYFKDEKKTAET
Mflv_1543|M.gilvum_PYR-GCK GPRVTIDKNTKVLDEDGNEVEPGSGKRGVIAKCGHIPVGYFKDEKKTAET
TH_1821|M.thermoresistible__bu GPRVTIDKNVVVLDEDGNEVKPGSGVRGLIAKRGHIPLGYYKDEKKTAET
MMAR_5001|M.marinum_M GPRVTIDHRTVVLDEEGNEVKPGSGVRGIIAKKGNIPVGYYKDEKKTAET
MUL_4075|M.ulcerans_Agy99 GPRVTIDHRTVVLDEEGNEVKPGSGVRGIIAKKGNIPVGYYKDEKKTAET
MAV_0644|M.avium_104 GPRVTIDHRTVVLDEEGNEVKPGSGVRGLIAKKGNIPVGYYKDEKKTAET
MAB_4163c|M.abscessus_ATCC_199 GPTVKISSTTTVLDEEGNPVQPGSGVRGLIAKSGHIPVGYFKDEKKTAET
MLBr_02546|M.leprae_Br4923 TVGPVVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGGGGK----
* :. . ** . *
Rv3513c|M.tuberculosis_H37Rv FRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAAL
Mb3542c|M.bovis_AF2122/97 FRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAAL
MSMEG_5914|M.smegmatis_MC2_155 FKTINGVRYAIPGDYAEVEADGSVTMLGRGSVSINSGGEKIYPEEVEAAL
Mvan_5215|M.vanbaalenii_PYR-1 FKTINGVRYAIPGDYATVEADGSVTMLGRGSVSINSGGEKIYPEEVEAAL
Mflv_1543|M.gilvum_PYR-GCK FRTYNGVRYAIPGDYAEVEADGTVTMLGRGSVSINSGGEKIYPEEVEAAL
TH_1821|M.thermoresistible__bu FKTINGVRYAIPGDWATVEADGTVTMLGRGSQSINSGGEKIYPEEVEGAL
MMAR_5001|M.marinum_M FKTINGVRYAIPGDYAMVEADGTVTMLGRGSVSINSGGEKIYPEEVEAAL
MUL_4075|M.ulcerans_Agy99 FKTINGVRYAIPGDYAMVEADGTVTMLGRGSVSINSGGEKIYPEEVEAAL
MAV_0644|M.avium_104 FKTFNGVRYAIPGDYALVEEDGTVTMLGRGSVSINSGGEKIYPEEVEGAL
MAB_4163c|M.abscessus_ATCC_199 FKTFNGVRYAIPGDWATVEADGTVTMLGRGSVSINTGGEKVFPEEVESVL
MLBr_02546|M.leprae_Br4923 -QIIDGLLS--SGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLI
: :*: .** . .: .. : : **.. * :***:::* *** :
Rv3513c|M.tuberculosis_H37Rv KGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAELDSFVRSEIAG
Mb3542c|M.bovis_AF2122/97 KGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAELDSFVRSEIAG
MSMEG_5914|M.smegmatis_MC2_155 KGHPDVFDALVVGVPDPRFGQHVAAVVHPREGTRPTLAELDAHVRTEIAG
Mvan_5215|M.vanbaalenii_PYR-1 KGHPDVFDALVVGVPDPRFGQHVAAVVQPREGTRPALADLDAFVRTQIAG
Mflv_1543|M.gilvum_PYR-GCK KGHPDVFDALVVGVPDPRFGQHVAAVVHPRDGARPSLADLDAFVRKEIAG
TH_1821|M.thermoresistible__bu KGHPDVFDALVVGVPDERFGQCVAAVVQRRPGTNPTLADLDAFVRQEIAG
MMAR_5001|M.marinum_M KGHPDVFDALVVGVPDPRYGQHVAAVVAPRPGSRPSLAELDGFVRSAIAG
MUL_4075|M.ulcerans_Agy99 KGHPDVFDALVVGVPDPRYGQHVAAVVAPRPGSRPSLAELDGFVRSAIAG
MAV_0644|M.avium_104 KGHPDVFDALVVGVPDPRYGQHVAAVVQPRPGTRPSLAELDRFVRSEIAG
MAB_4163c|M.abscessus_ATCC_199 KGHPAVFDAVVVGVPDEKWGQHVGAVIAVREGVELTFEDLDAHARKEIAG
MLBr_02546|M.leprae_Br4923 SGHPEVVEATAIGVDDKEWGARLRAFVVKKQDATIDEDAIKAYVRDHLAR
.*** *.:* .:** * .:* : *.: : . :. ..* :*
Rv3513c|M.tuberculosis_H37Rv YKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGS---
Mb3542c|M.bovis_AF2122/97 YKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGS---
MSMEG_5914|M.smegmatis_MC2_155 YKVPRSLWLVDEIKRSPAGKPDYRWAKDVTEERPADEVHANHVAANAK--
Mvan_5215|M.vanbaalenii_PYR-1 YKVPRSLWLVDEVKRSPAGKPDYRWAKDVTEERPADDVHANHVGAK----
Mflv_1543|M.gilvum_PYR-GCK YKVPRSLWLVDEIKRSPAGKPDYRWAKDTTEERPADEVHAKHVGAN----
TH_1821|M.thermoresistible__bu YKVPRKIWWVDEIQRTPAGKPDYRWAKEQTEAREPDEVHSSHAGAGGGAK
MMAR_5001|M.marinum_M YKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAAHVSA-----
MUL_4075|M.ulcerans_Agy99 YKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAAHVSA-----
MAV_0644|M.avium_104 YKVPRSLWLVDEVKRSPAGKPDYRWAKEQTEARPADDVHAAHVSA-----
MAB_4163c|M.abscessus_ATCC_199 YKVPRSIWIVDSVKRNPAGKADYRWAKEVSETEKVDLVNSKHVNTGA---
MLBr_02546|M.leprae_Br4923 YKVPREVIFLEELPRNPTGKVLKRELRDFEVH------------------
*****.: ::.: *.*:** * ::