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M. tuberculosis H37Rv Rv3454 (-)

annotation: PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN
coordinates: 3874822 - 3876090
length: 422

MAQGLKLGLHIPLWAGYACSTLIIFPLVVYGMKVLSQLQLWTTPLWLILMAAPFGYLVVSHPDSIGQFFS
YAGKDGHGGLSFGSVLLAAGVCLSLIAQIAEQIDYLRFMPPRTPENANRWWTWTLLAGPGWVAFGATKQI
IGLFLAVYLMANIPGSSTIANQPVHQFMQIYRTFVPGWLALTLAVILVVLSQIKINVTNAYSGSLAWTNS
FTRLTKHYPGRVVFLGVNLAIALILMEANMFDFLNTILGCYANCGMAWVVAVASDIGFNKYLLGLSPKTP
EFRRGMLYAINPVGFGSLLLAAGLSIVTFFGGLGAALQPYSPLVAIVTALVMPPILAAATKGKYYLRRTH
DGIDLPMYDEHGNPSAAVLTCHVCHQDFERPDMLACQTHGAHVCSLCLSTDKQAEHVLPGLARAHIPGDQ
VP
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv3454--100% (422)PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3483-0.099.76% (422) transmembrane protein
M. gilvum PYR-GCK-----
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_2635c-1e-17771.98% (414) hypothetical protein MAB_2635c
M. marinum MMMAR_1096-0.085.05% (408) hypothetical protein MMAR_1096
M. avium 104-----
M. smegmatis MC2 155-----
M. thermoresistible (build 8)-----
M. ulcerans Agy99-----
M. vanbaalenii PYR-1-----

CLUSTAL 2.0.9 multiple sequence alignment


Rv3454|M.tuberculosis_H37Rv         --------------------------------------------------
Mb3483|M.bovis_AF2122/97            MPGVITNSE-----SPTA-ADHDRITATRETLEDYTLRLAPRSYRRWPPA
MMAR_1096|M.marinum_M               MQDTDVSQV-----SPSAPADLAEITAAKETLEDYTLRFAPRSYRRWSPA
MAB_2635c|M.abscessus_ATCC_199      MTDTLDTTASAPVSSAPSSHDVAESAALRETLEDYTLRFAPRRFRRWSPA
                                                                                      

Rv3454|M.tuberculosis_H37Rv         --------------------------------------------------
Mb3483|M.bovis_AF2122/97            VVGISALGGIAYLADFAIGANVGITWGTANALCGIAIFALVVFVTGLPLA
MMAR_1096|M.marinum_M               VVGISALGGIAYLADFAIGANIGITWGTTNALWGIAIFAAVVFTTGLPLA
MAB_2635c|M.abscessus_ATCC_199      VVGVTALGGIAYLADFAIGANIGISYGTGNALWGIGVFAVIIILTGIPLS
                                                                                      

Rv3454|M.tuberculosis_H37Rv         ---------------------------------------------MAQGL
Mb3483|M.bovis_AF2122/97            YYAARYNIDLDLITRGSGFGYYGSVVTNVIFATFTFIFFALEGSIMAQGL
MMAR_1096|M.marinum_M               YYAARYNIDLDLITRGSGFGYYGSVVTNVIFATFTFIFFALEGSIMAQGL
MAB_2635c|M.abscessus_ATCC_199      YYAARYNIDLDLITRGSGFGYYGSIVTNIIYATFTFIFFALEGSIMAQGL
                                                                                 *****

Rv3454|M.tuberculosis_H37Rv         KLGLHIPLWAGYACSTLIIFPLVVYGMKVLSQLQLWTTPLWLILMAAPFG
Mb3483|M.bovis_AF2122/97            KLGLHIPLWAGYACSTLIIFPLVVYGMKVLSQLQLWTTPLWLILMAAPFG
MMAR_1096|M.marinum_M               NLGLHIPLWLGYAFSTLLIFPLVIYGMKVLSQLQLWTTPLWLILMVAPFG
MAB_2635c|M.abscessus_ATCC_199      KLGLGVPLPVGYAMSTIIIIPLVIYGMKALSVLQVWTTPLWLVMMVIPFV
                                    :*** :**  *** **::*:***:****.** **:*******::*. ** 

Rv3454|M.tuberculosis_H37Rv         YLVVSHPDSIGQFFSYAGKDGHGGLSFGSVLLAAGVCLSLIAQIAEQIDY
Mb3483|M.bovis_AF2122/97            YLVVSHPDSIGQFFSYAGKDGHGGLSFGSVLLAAGVCLSLIAQIAEQIDY
MMAR_1096|M.marinum_M               YLLISHPESVAQFFAYAGKDGRATASIGSALMAAGVCLALIAQIAEQIDY
MAB_2635c|M.abscessus_ATCC_199      YLLVRHPDSIGAFFAYGGKDGQG-VNLGSIMLAAGVCLSLIAQIAEQIDY
                                    **:: **:*:. **:*.****:.  .:** ::******:***********

Rv3454|M.tuberculosis_H37Rv         LRFMPPRTPENANRWWTWTLLAGPGWVAFGATKQIIGLFLAVYLMANIPG
Mb3483|M.bovis_AF2122/97            LRFMPPRTPENANRWWTWTLLAGPGWVAFGATKQIIGLFLAVYLMANIPG
MMAR_1096|M.marinum_M               LRFMPPRTPKNSRRWWAWMLLAGPGWVIFGAAKQIIGLFLAVYLLSNVAG
MAB_2635c|M.abscessus_ATCC_199      LRFMPPKTPENSRRWWTAMLLAGPGWVLFGAIKQVIGLFLAVYLIANVAG
                                    ******:**:*:.***:  ******** *** **:*********::*:.*

Rv3454|M.tuberculosis_H37Rv         SSTIANQPVHQFMQIYRTFVPGWLALTLAVILVVLSQIKINVTNAYSGSL
Mb3483|M.bovis_AF2122/97            SSTIANQPVHQFMQIYRTFVPGWLALTLAVILVILSQIKINVTNAYSGSL
MMAR_1096|M.marinum_M               AADFANQPVHQFMQIYRNFMPGWLALTLAVILVVLSQVKINVTNAYSGSL
MAB_2635c|M.abscessus_ATCC_199      GATVANQPVHQFLEIYQNMMPHWLAITLAVILVVISQIKINVTNAYSGSL
                                    .: .********::**:.::* ***:*******::**:************

Rv3454|M.tuberculosis_H37Rv         AWTNSFTRLTKHYPGRVVFLGVNLAIALILMEANMFDFLNTILGCYANCG
Mb3483|M.bovis_AF2122/97            AWTNSFTRLTKHYPGRVVFLGVNLAIALILMEANMFDFLNTILGCYANCG
MMAR_1096|M.marinum_M               AWTNSFTRVTKHYPGRVMFLGVNLTIALILMEANMFDFLNTILGFYANCG
MAB_2635c|M.abscessus_ATCC_199      AWTNSFTRITKHYPGRLIFVLFNLLIALVLMEANMFDFLNTILGFYANCG
                                    ********:*******::*: .** ***:*************** *****

Rv3454|M.tuberculosis_H37Rv         MAWVVAVASDIGFNKYLLGLSPKTPEFRRGMLYAINPVGFGSLLLAAGLS
Mb3483|M.bovis_AF2122/97            MAWVVAVASDIGFNKYLLGLSPKTPEFRRGMLYAINPVGFGSLLLAAGLS
MMAR_1096|M.marinum_M               MAWVVTVASDIVFNKFLLGLSPKTPEFRRGMLYAINPVGFGSMLLAAGLS
MAB_2635c|M.abscessus_ATCC_199      MAWVVTVASDIAINKYLLKLSPKEPEFRRGMLYDVNPVGFVSMLLSAGIS
                                    *****:***** :**:** **** ********* :***** *:**:**:*

Rv3454|M.tuberculosis_H37Rv         IVTFFGGLGAALQPYSPLVAIVTALVMPPILAAATKGKYYLRRTHDGIDL
Mb3483|M.bovis_AF2122/97            IVTFFGGLGAALQPYSPLVAIVTALVMPPILAAATKGKYYLRRTHDGIDL
MMAR_1096|M.marinum_M               IVAFFGGLGETLRPYSPLVAISVALVMPPILAIATKGKYYLRRTHDGIEL
MAB_2635c|M.abscessus_ATCC_199      ILVFFGVFGATIRPYSPIVAVVIAFVLPPILALVTRGRYYLRRSDDGIDL
                                    *:.*** :* :::****:**:  *:*:***** .*:*:*****:.***:*

Rv3454|M.tuberculosis_H37Rv         PMYDEHGNPSAAVLTCHVCHQDFERPDMLACQTHG-----AHVCSLCLST
Mb3483|M.bovis_AF2122/97            PMYDEHGNPSAAVLTCHVCHQDFERPDMLACQTHG-----AHVCSLCLST
MMAR_1096|M.marinum_M               PMYDEHGNPSAEHLNCHVCRQNFERPDMAACQTHD-----AHVCSLCLST
MAB_2635c|M.abscessus_ATCC_199      PMYDEYGNPSGELLHCAVSGIEFERPDMLASAKPGPNGEVQYVSSLSLAT
                                    *****:****.  * * *.  :****** *. . .      :*.**.*:*

Rv3454|M.tuberculosis_H37Rv         DKQAEHVLPGLARAHIPGDQVP
Mb3483|M.bovis_AF2122/97            DKQAEHVLPGLARAHIPGDQVP
MMAR_1096|M.marinum_M               DKQAEHVLS----AHP------
MAB_2635c|M.abscessus_ATCC_199      DRIGEHVLP----ADPPRP---
                                    *: .****.    *.