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VKTWPAPTAPTPVRATVTVPGSKSQTNRALVLAALAAAQGRGASTISGALRSRDTELMLDALQTLGLRVD GVGSELTVSGRIEPGPGARVDCGLAGTVLRFVPPLAALGSVPVTFDGDQQARGRPIAPLLDALRELGVAV DGTGLPFRVRGNGSLAGGTVAIDASASSQFVSGLLLSAASFTDGLTVQHTGSSLPSAPHIAMTAAMLRQA GVDIDDSTPNRWQVRPGPVAARRWDIEPDLTNAVAFLSAAVVSGGTVRITGWPRVSVQPADHILAILRQL NAVVIHADSSLEVRGPTGYDGFDVDLRAVGELTPSVAALAALASPGSVSRLSGIAHLRGHETDRLAALST EINRLGGTCRETPDGLVITATPLRPGIWRAYADHRMAMAGAIIGLRVAGVEVDDIAATTKTLPEFPRLWA EMVGPGQGWGYPQPRSGQRARRATGQGSGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3227 | aroA | - | 100% (450) | 3-phosphoshikimate 1-carboxyvinyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3256 | aroA | 0.0 | 99.78% (450) | 3-phosphoshikimate 1-carboxyvinyltransferase |
| M. gilvum PYR-GCK | Mflv_4695 | - | 1e-171 | 71.66% (427) | 3-phosphoshikimate 1-carboxyvinyltransferase |
| M. leprae Br4923 | MLBr_00792 | aroA | 0.0 | 78.97% (428) | 3-phosphoshikimate 1-carboxyvinyltransferase |
| M. abscessus ATCC 19977 | MAB_3546 | - | 1e-149 | 61.79% (424) | 3-phosphoshikimate 1-carboxyvinyltransferase |
| M. marinum M | MMAR_1320 | aroA | 0.0 | 82.24% (428) | 3-phosphoshikimate 1-carboxyvinyltransferase AroA |
| M. avium 104 | MAV_4182 | aroA | 0.0 | 82.98% (423) | 3-phosphoshikimate 1-carboxyvinyltransferase |
| M. smegmatis MC2 155 | MSMEG_1890 | aroA | 1e-162 | 67.83% (429) | 3-phosphoshikimate 1-carboxyvinyltransferase |
| M. thermoresistible (build 8) | TH_0661 | aroA | 1e-168 | 73.11% (409) | 3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE AROA |
| M. ulcerans Agy99 | MUL_2560 | aroA | 0.0 | 81.78% (428) | 3-phosphoshikimate 1-carboxyvinyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1771 | - | 1e-174 | 69.20% (448) | 3-phosphoshikimate 1-carboxyvinyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4695|M.gilvum_PYR-GCK ------MVGVSNWAAPSTATPVHATVTVPGSKSQTNRALVLAALAAREG-
Mvan_1771|M.vanbaalenii_PYR-1 ---------MSTWPAPSTATPVHATVTVPGSKSQTNRALVLAALAVPQG-
TH_0661|M.thermoresistible__bu -------------------------VTVPGSKSLTNRALILAALATADG-
Rv3227|M.tuberculosis_H37Rv ---------MKTWPAPTAPTPVRATVTVPGSKSQTNRALVLAALAAAQGR
Mb3256|M.bovis_AF2122/97 ---------MKTWPAPTAPTPVRATVTVPGSKSQTNRALVLAALAAAQGR
MMAR_1320|M.marinum_M ------MSSIEPWPAPFAPTPVHATVTVPGSKSQTNRTLVLAALAAAQGQ
MUL_2560|M.ulcerans_Agy99 ------MSSIEPWPAPFAPTPVHATVTVPGSKSQTNRTLVLAALAAAQGQ
MLBr_00792|M.leprae_Br4923 -------MSIESWTAPVASTPVQANVTIPGSKSQTNRALMLAALAAAQGQ
MAV_4182|M.avium_104 ---------MTTWAAPLAPQPVHATVTVPGSKSQTNRALVLAALAAAQGR
MSMEG_1890|M.smegmatis_MC2_155 MSARADEEQKPHWAAPSTTAPVDATVTVPGSKSLTNRALILAALATSQG-
MAB_3546|M.abscessus_ATCC_1997 -------MTSGLWQAPTIDGSICATITMPGSKSQTNRALVLAALAAREG-
:*:***** ***:*:*****. :*
Mflv_4695|M.gilvum_PYR-GCK -SSRISGALRSRDTDLMIGALETLGLSVAASDSDPAD---LTVSGTLAPA
Mvan_1771|M.vanbaalenii_PYR-1 -SSTISGALRSRDTDLMISALQGLGVVVEAPDTDGSDGTELTVSGALAPK
TH_0661|M.thermoresistible__bu -TSTISGALRSRDTDLMVGALRALGVTVDYGDPD-SE---LTVGGGIAPA
Rv3227|M.tuberculosis_H37Rv GASTISGALRSRDTELMLDALQTLGLRVDGVGSE------LTVSGRIEPG
Mb3256|M.bovis_AF2122/97 GASTISGALRSRDTELMLDALQTLGLRVDGVGSE------LTVSGRIEPG
MMAR_1320|M.marinum_M GSSTITGALRSRDTDLMIEALQTLGLRVDGTGSE------LTVSGRIRPG
MUL_2560|M.ulcerans_Agy99 GSSTITGALRSRDTDLMIEALQTLGLRVDGTGSE------LTVSGRIRPC
MLBr_00792|M.leprae_Br4923 GTSTIGGALRSRDTELMISALRTLGLHVDEAGSV------LTVNGRITPG
MAV_4182|M.avium_104 GTPTLSGALRSRDTDLMIGALRTLGLRVDGTGPE------LTVSGHIAPG
MSMEG_1890|M.smegmatis_MC2_155 -TSTISGALRSRDTDLMIEAIRTLGVTVDISAADP---TELTVHGSIEPA
MAB_3546|M.abscessus_ATCC_1997 GTSTVSGALRSRDTDLMIRALRSLGFDIIGDGTD------LTVSPGAGDD
:. : ********:**: *:. **. : . ***
Mflv_4695|M.gilvum_PYR-GCK AEARVDCGLAGTVLRFVPPIAALSAQTVTFDGDEQARSRPIAPLLDGLRT
Mvan_1771|M.vanbaalenii_PYR-1 AGARIDCGLAGTVLRFVPPVAALTTETVTFDGDEQARARPIAPLLDGLRA
TH_0661|M.thermoresistible__bu PGARVDCGLAGTVLRFVPPVAALGTGTVTFDGDEQARVRPIAPLLQALRG
Rv3227|M.tuberculosis_H37Rv PGARVDCGLAGTVLRFVPPLAALGSVPVTFDGDQQARGRPIAPLLDALRE
Mb3256|M.bovis_AF2122/97 PGARVDCGLAGTVLRFVPPLAALGSVPVTFDGDQQARGRPIAPLLDALRE
MMAR_1320|M.marinum_M PEARVDCGLAGTVLRFVPPLAALSAAPITFDGDEQARARPIAPLLDALRG
MUL_2560|M.ulcerans_Agy99 PEARVDCGLAGTVLRFAPPLAALSAAPITFDGDEQARARPIAPLLDALRG
MLBr_00792|M.leprae_Br4923 EDAQVDCGLAGTVLRFVPPLAALSANPVTFDGDEQARARPITPLLDALRG
MAV_4182|M.avium_104 PHARVDCGLAGTVLRFVPPLAALADAVVEFDGDEQARARPIAPLLDALRG
MSMEG_1890|M.smegmatis_MC2_155 TDATVDCGLAGTVLRFVPPVAALSRSSVTFDGDEQARSRPIAPLLDGLRR
MAB_3546|M.abscessus_ATCC_1997 DASTVDCGLAGTVLRFLPPVAALRHAPTVFDGDEQARARPIAPLLDALRS
: :*********** **:*** ****:*** ***:***:.**
Mflv_4695|M.gilvum_PYR-GCK LGVDIDGDGLPFAVRGTGTVAGGTVEIDASGSSQFVSGLLLSGAAFTDGL
Mvan_1771|M.vanbaalenii_PYR-1 LGVAIDGDGLPFSVRGQGSVRGGTVEIDASGSSQFVSGLLLSGAAFTEGL
TH_0661|M.thermoresistible__bu LGVQIEGDGLPFRVHGRGEVIGGTVEIDASASSQFVSGLLLSGAAFRDGL
Rv3227|M.tuberculosis_H37Rv LGVAVDGTGLPFRVRGNGSLAGGTVAIDASASSQFVSGLLLSAASFTDGL
Mb3256|M.bovis_AF2122/97 LGVAVDGTGLPFRVHGNGSLAGGTVAIDASASSQFVSGLLLSAASFTDGL
MMAR_1320|M.marinum_M LGVPVDGAGLPFRVQGTGSVAGGTVAIDASASSQFVSGLLLSGASFTDGL
MUL_2560|M.ulcerans_Agy99 LGVPVDGAGLPFRVQGTGSVAGGTVAIDASASSQFVSGLLLSGASFTDGL
MLBr_00792|M.leprae_Br4923 LGVPVDGVGLPFQVQGSGSVAGGTVAIDASASSQFVSGLLLCAASFTQGV
MAV_4182|M.avium_104 LGVRIEGTALPFRVHGGGALAGGTVAIDASASSQFVSGLLLCAASFTEGL
MSMEG_1890|M.smegmatis_MC2_155 LGVRLDGDGLPFTVRGTGTVSGGTVEIDASGSSQFVSGLLLSGAGFENGL
MAB_3546|M.abscessus_ATCC_1997 TGVGIDGQHLPFTVTGTGQVQGGEVGVDASGSSQFVSGLLLSGAAFSAGL
** ::* *** * * * : ** * :***.**********..*.* *:
Mflv_4695|M.gilvum_PYR-GCK TIVHTGDSVPSAPHIAMTVSMLRDAGVEVDDSAPDRWRVSPGPIGARDWV
Mvan_1771|M.vanbaalenii_PYR-1 TVVHTGGAVPSAPHIAMTVSMLRDAGVEVDDSAADRWRVAPGPIAARHWA
TH_0661|M.thermoresistible__bu TVVHTGDSVPSAPHVAMTVAMLRQAGVDVDDSRPSRWRVAPGPVAARHWV
Rv3227|M.tuberculosis_H37Rv TVQHTGSSLPSAPHIAMTAAMLRQAGVDIDDSTPNRWQVRPGPVAARRWD
Mb3256|M.bovis_AF2122/97 TVQHTGSSLPSAPHIAMTAAMLRQAGVDIDDSTPNRWQVRPGPVAARRWD
MMAR_1320|M.marinum_M TVQHTGSELPSAPHIAMTVQMLRQAGVDVDDSIPNRWLVRPGALRPRHWD
MUL_2560|M.ulcerans_Agy99 TVQHTGSELPSAPHIAMTVQMLRQAGVDVDDSIPNRWLVRPGALRPRHWD
MLBr_00792|M.leprae_Br4923 TVQHTGSPVPSAPHIAMTVMMLRQAGVQVDDSVGNRWQVRPGTVAARHWV
MAV_4182|M.avium_104 TVQHTGAALPSAPHIAMTVAMLRQAGVDVDDSVPNRWQVRPGPVAARHWE
MSMEG_1890|M.smegmatis_MC2_155 TIVHTGVSVPSAPHVAMTVAMLRDAGVEVDDSVANRWQVNPGPVAARSWN
MAB_3546|M.abscessus_ATCC_1997 TAMNTADVLPSGPHVVMTVTMLREAGIAVDDSVPGRWRIDPQPIPAHQWV
* :*. :**.**:.**. ***:**: :*** .** : * .: .: *
Mflv_4695|M.gilvum_PYR-GCK IEPDLSNSVPFLAAAVVSGGAVRITGWPTVSIQPADTILKILAGLNGEVR
Mvan_1771|M.vanbaalenii_PYR-1 VEPDLSNAVPFLAAAVISGGTVRVTGWPTVSTQPAATILSLLTSLGSEVR
TH_0661|M.thermoresistible__bu IEPDLSNAVPFLSAAVVSGGSVRVMGWPASSIQPADIVVNLLKKLDSVVL
Rv3227|M.tuberculosis_H37Rv IEPDLTNAVAFLSAAVVSGGTVRITGWPRVSVQPADHILAILRQLNAVVI
Mb3256|M.bovis_AF2122/97 IEPDLTNAVAFLSAAVVSGGTVRITGWPRVSVQPADHILAILRQLNAVVI
MMAR_1320|M.marinum_M VEPDLTNAVAFLAAAVVTGGTVTITGWPADSVQPAKNILDILQTLNSTVR
MUL_2560|M.ulcerans_Agy99 AEPDLTNAVAFLAAAVVTGGTVTITGWPADSVQPAKNILDILQTLNSTVR
MLBr_00792|M.leprae_Br4923 VEPDLTNAVAFLAAAAVSGGTVRITGWPKTSVQPADNILNILFRLNVVVN
MAV_4182|M.avium_104 VEPDLTNAVPFLAAAVVSGGTVRITGWPADSVQPADNILSVLSKLNAVVS
MSMEG_1890|M.smegmatis_MC2_155 IEPDLSNSTPFLAAALVTGGTVRIAGWPTVSIQPADTILELLATVGGSVR
MAB_3546|M.abscessus_ATCC_1997 IEPDLSNALAFIAPALATGGTVRITGWPRQSTQPARQIEDVVRQFAQTVS
****:*: .*::.* :**:* : *** * *** : :: . *
Mflv_4695|M.gilvum_PYR-GCK KGSSYLEVQGATNYGGIDVDLRDVGELAPSVAAMAALADPGSVSRLRGIA
Mvan_1771|M.vanbaalenii_PYR-1 QGNSHLEVQGATSYDGIDVDLRDVGELAPSVAAMAALASPGSVSRLRGIA
TH_0661|M.thermoresistible__bu RGDSYIEVRGAAQYGGIDADLHDVGELTPAIAALAALAVPGSVSRISGVA
Rv3227|M.tuberculosis_H37Rv HADSSLEVRGPTGYDGFDVDLRAVGELTPSVAALAALASPGSVSRLSGIA
Mb3256|M.bovis_AF2122/97 HADSSLEVRGPTGYDGFDVDLRAVGELTPSVAALAALASPGSVSRLSGIA
MMAR_1320|M.marinum_M HIDSCLQVQGPQTYRGFDVDLRDVGELTPSVAALAALASPGSVSRLAGIA
MUL_2560|M.ulcerans_Agy99 HIDSCLQVQGPQSYRGFDVDLRDVGELTPSVAALAALASPGSVSRLAGIA
MLBr_00792|M.leprae_Br4923 QTDSFLEVQGSTVYDGFDVDLRDVGELTPSVAALAALATPGSVSQLHGIA
MAV_4182|M.avium_104 QTDSSLEVRGSGSYDGFDVDLRAVGELTPSVAALAALATPGSVSRLSGIA
MSMEG_1890|M.smegmatis_MC2_155 EADGHLEVTGAHEYGGFEADLHDVGELAPTVAALAALAKEGSTSQLRGIA
MAB_3546|M.abscessus_ATCC_1997 LTDTHLEVTGQSGYGGVDLDLSEVGELTPTVAALSALAESGAVSTLRGIA
. ::* * * *.: ** ****:*::**::*** *:.* : *:*
Mflv_4695|M.gilvum_PYR-GCK HLRGHETDRLAALSTEINGIGGQCEETEDGLVITAREMHGGTWSSYADHR
Mvan_1771|M.vanbaalenii_PYR-1 HLRGHETDRLAALSAELNRLGGQCEETDDGLVITARQMHGGVWRSYADHR
TH_0661|M.thermoresistible__bu HLRGHETDRLAALSTEINRLGGQCEETDDGLVITARPMHGGRWQSYADHR
Rv3227|M.tuberculosis_H37Rv HLRGHETDRLAALSTEINRLGGTCRETPDGLVITATPLRPGIWRAYADHR
Mb3256|M.bovis_AF2122/97 HLRGHETDRLAALSTEINRLGGTCRETPDGLVITATPLRPGIWRAYADHR
MMAR_1320|M.marinum_M HLRGHETDRLAALSTEINRLGGNCEQTSDGLVITATPLRPGSWRAYADHR
MUL_2560|M.ulcerans_Agy99 HLRGHETDRLAALSTEINRLGGNCEQTSDGLVITATPLRPGSWRAYADHR
MLBr_00792|M.leprae_Br4923 HLRGHETDRLAALSTEINRLGGDCQETSDGLIITATPLRPGVWRAYADHR
MAV_4182|M.avium_104 HLRGHETDRLAALSAEINRLGGDCTETPDGLVITATPLHSGVWQAYADHR
MSMEG_1890|M.smegmatis_MC2_155 HLRGHETDRLAALTTEINGLGGDCRETDDGLLITARPLHGGTWRSYADHR
MAB_3546|M.abscessus_ATCC_1997 HLRGHETDRLKALAHEINALGGRCEETQDGLRIVATDLRGGVWGSYADHR
********** **: *:* :** * :* *** *.* :: * * :*****
Mflv_4695|M.gilvum_PYR-GCK MATAGAIIGLRVPGIEVEDIGTTAKTLPDFPQLWADMLGGQTDDLQ----
Mvan_1771|M.vanbaalenii_PYR-1 MATAGAIVGLRVPGVEVEDIGTTAKTLPDFPQLWADMLAGQTDLQA----
TH_0661|M.thermoresistible__bu MAMAGAIIGLRVPGVEIEDIGTTAKTLPEFPQLWAAMLAGQDTRDV----
Rv3227|M.tuberculosis_H37Rv MAMAGAIIGLRVAGVEVDDIAATTKTLPEFPRLWAEMVGPGQGWGYPQPR
Mb3256|M.bovis_AF2122/97 MAMAGAIIGLRVAGVEVDDIAATTKTLPEFPRLWAEMVGPGQGWGYPQPR
MMAR_1320|M.marinum_M MAMAGAIVGLRVAGVEVDDIGATSKTLPEFPQLWTEMVE-----------
MUL_2560|M.ulcerans_Agy99 MAMAGAIVGLRVAGVEVDDIGATSKTLPEFPQLWTEMVE-----------
MLBr_00792|M.leprae_Br4923 MAMAGAIVGLRVSGVEVDDIGATHKTLPQFPQLWANMLK-----------
MAV_4182|M.avium_104 MAMAGAIVGLRVAGVRVDDIGATGKTLPDFPRLWARMLDTSLPDG-----
MSMEG_1890|M.smegmatis_MC2_155 MATAGAIVGLRVPGVVVENIETTAKTLPDFPSMWVDMLAGE---------
MAB_3546|M.abscessus_ATCC_1997 MATAGALVGLKVPGVSVDDIATTSKTLPDFPGMWADMIAQS---------
** ***::**:*.*: :::* :* ****:** :*. *:
Mflv_4695|M.gilvum_PYR-GCK ---------QGPSARETPGR
Mvan_1771|M.vanbaalenii_PYR-1 ---------GAPHAGRNQGR
TH_0661|M.thermoresistible__bu ---------DMPGGGA----
Rv3227|M.tuberculosis_H37Rv SGQRARRATGQGSGG-----
Mb3256|M.bovis_AF2122/97 SGQRARRATGQGSGG-----
MMAR_1320|M.marinum_M -----------GSSG-----
MUL_2560|M.ulcerans_Agy99 -----------GSSG-----
MLBr_00792|M.leprae_Br4923 -----------RSTG-----
MAV_4182|M.avium_104 -----------EEHGM----
MSMEG_1890|M.smegmatis_MC2_155 -----------PGRNQQR--
MAB_3546|M.abscessus_ATCC_1997 -----------ERAS-----