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VSSIEPWPAPFAPTPVHATVTVPGSKSQTNRTLVLAALAAAQGQGSSTITGALRSRDTDLMIEALQTLGL RVDGTGSELTVSGRIRPCPEARVDCGLAGTVLRFAPPLAALSAAPITFDGDEQARARPIAPLLDALRGLG VPVDGAGLPFRVQGTGSVAGGTVAIDASASSQFVSGLLLSGASFTDGLTVQHTGSELPSAPHIAMTVQML RQAGVDVDDSIPNRWLVRPGALRPRHWDAEPDLTNAVAFLAAAVVTGGTVTITGWPADSVQPAKNILDIL QTLNSTVRHIDSCLQVQGPQSYRGFDVDLRDVGELTPSVAALAALASPGSVSRLAGIAHLRGHETDRLAA LSTEINRLGGNCEQTSDGLVITATPLRPGSWRAYADHRMAMAGAIVGLRVAGVEVDDIGATSKTLPEFPQ LWTEMVEGSSG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2560 | aroA | - | 100% (431) | 3-phosphoshikimate 1-carboxyvinyltransferase |
| M. ulcerans Agy99 | MUL_3950 | murA | 3e-08 | 22.80% (421) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3256 | aroA | 0.0 | 81.78% (428) | 3-phosphoshikimate 1-carboxyvinyltransferase |
| M. gilvum PYR-GCK | Mflv_4695 | - | 1e-171 | 71.40% (430) | 3-phosphoshikimate 1-carboxyvinyltransferase |
| M. tuberculosis H37Rv | Rv3227 | aroA | 0.0 | 81.78% (428) | 3-phosphoshikimate 1-carboxyvinyltransferase |
| M. leprae Br4923 | MLBr_00792 | aroA | 0.0 | 80.19% (429) | 3-phosphoshikimate 1-carboxyvinyltransferase |
| M. abscessus ATCC 19977 | MAB_3546 | - | 1e-148 | 62.65% (423) | 3-phosphoshikimate 1-carboxyvinyltransferase |
| M. marinum M | MMAR_1320 | aroA | 0.0 | 99.07% (431) | 3-phosphoshikimate 1-carboxyvinyltransferase AroA |
| M. avium 104 | MAV_4182 | aroA | 0.0 | 79.34% (426) | 3-phosphoshikimate 1-carboxyvinyltransferase |
| M. smegmatis MC2 155 | MSMEG_1890 | aroA | 1e-162 | 66.82% (428) | 3-phosphoshikimate 1-carboxyvinyltransferase |
| M. thermoresistible (build 8) | TH_0661 | aroA | 1e-165 | 70.56% (411) | 3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE AROA |
| M. vanbaalenii PYR-1 | Mvan_1771 | - | 1e-172 | 71.82% (433) | 3-phosphoshikimate 1-carboxyvinyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4695|M.gilvum_PYR-GCK ------MVGVSNWAAPSTATPVHATVTVPGSKSQTNRALVLAALAAREG-
Mvan_1771|M.vanbaalenii_PYR-1 ---------MSTWPAPSTATPVHATVTVPGSKSQTNRALVLAALAVPQG-
TH_0661|M.thermoresistible__bu -------------------------VTVPGSKSLTNRALILAALATADG-
MUL_2560|M.ulcerans_Agy99 ------MSSIEPWPAPFAPTPVHATVTVPGSKSQTNRTLVLAALAAAQGQ
MMAR_1320|M.marinum_M ------MSSIEPWPAPFAPTPVHATVTVPGSKSQTNRTLVLAALAAAQGQ
Mb3256|M.bovis_AF2122/97 ---------MKTWPAPTAPTPVRATVTVPGSKSQTNRALVLAALAAAQGR
Rv3227|M.tuberculosis_H37Rv ---------MKTWPAPTAPTPVRATVTVPGSKSQTNRALVLAALAAAQGR
MLBr_00792|M.leprae_Br4923 -------MSIESWTAPVASTPVQANVTIPGSKSQTNRALMLAALAAAQGQ
MAV_4182|M.avium_104 ---------MTTWAAPLAPQPVHATVTVPGSKSQTNRALVLAALAAAQGR
MSMEG_1890|M.smegmatis_MC2_155 MSARADEEQKPHWAAPSTTAPVDATVTVPGSKSLTNRALILAALATSQG-
MAB_3546|M.abscessus_ATCC_1997 -------MTSGLWQAPTIDGSICATITMPGSKSQTNRALVLAALAAREG-
:*:***** ***:*:*****. :*
Mflv_4695|M.gilvum_PYR-GCK -SSRISGALRSRDTDLMIGALETLGLSVAASDSDPAD---LTVSGTLAPA
Mvan_1771|M.vanbaalenii_PYR-1 -SSTISGALRSRDTDLMISALQGLGVVVEAPDTDGSDGTELTVSGALAPK
TH_0661|M.thermoresistible__bu -TSTISGALRSRDTDLMVGALRALGVTVDYGDPD-SE---LTVGGGIAPA
MUL_2560|M.ulcerans_Agy99 GSSTITGALRSRDTDLMIEALQTLGLRVDGTGSE------LTVSGRIRPC
MMAR_1320|M.marinum_M GSSTITGALRSRDTDLMIEALQTLGLRVDGTGSE------LTVSGRIRPG
Mb3256|M.bovis_AF2122/97 GASTISGALRSRDTELMLDALQTLGLRVDGVGSE------LTVSGRIEPG
Rv3227|M.tuberculosis_H37Rv GASTISGALRSRDTELMLDALQTLGLRVDGVGSE------LTVSGRIEPG
MLBr_00792|M.leprae_Br4923 GTSTIGGALRSRDTELMISALRTLGLHVDEAGSV------LTVNGRITPG
MAV_4182|M.avium_104 GTPTLSGALRSRDTDLMIGALRTLGLRVDGTGPE------LTVSGHIAPG
MSMEG_1890|M.smegmatis_MC2_155 -TSTISGALRSRDTDLMIEAIRTLGVTVDISAADP---TELTVHGSIEPA
MAB_3546|M.abscessus_ATCC_1997 GTSTVSGALRSRDTDLMIRALRSLGFDIIGDGTD------LTVSPGAGDD
:. : ********:**: *:. **. : . ***
Mflv_4695|M.gilvum_PYR-GCK AEARVDCGLAGTVLRFVPPIAALSAQTVTFDGDEQARSRPIAPLLDGLRT
Mvan_1771|M.vanbaalenii_PYR-1 AGARIDCGLAGTVLRFVPPVAALTTETVTFDGDEQARARPIAPLLDGLRA
TH_0661|M.thermoresistible__bu PGARVDCGLAGTVLRFVPPVAALGTGTVTFDGDEQARVRPIAPLLQALRG
MUL_2560|M.ulcerans_Agy99 PEARVDCGLAGTVLRFAPPLAALSAAPITFDGDEQARARPIAPLLDALRG
MMAR_1320|M.marinum_M PEARVDCGLAGTVLRFVPPLAALSAAPITFDGDEQARARPIAPLLDALRG
Mb3256|M.bovis_AF2122/97 PGARVDCGLAGTVLRFVPPLAALGSVPVTFDGDQQARGRPIAPLLDALRE
Rv3227|M.tuberculosis_H37Rv PGARVDCGLAGTVLRFVPPLAALGSVPVTFDGDQQARGRPIAPLLDALRE
MLBr_00792|M.leprae_Br4923 EDAQVDCGLAGTVLRFVPPLAALSANPVTFDGDEQARARPITPLLDALRG
MAV_4182|M.avium_104 PHARVDCGLAGTVLRFVPPLAALADAVVEFDGDEQARARPIAPLLDALRG
MSMEG_1890|M.smegmatis_MC2_155 TDATVDCGLAGTVLRFVPPVAALSRSSVTFDGDEQARSRPIAPLLDGLRR
MAB_3546|M.abscessus_ATCC_1997 DASTVDCGLAGTVLRFLPPVAALRHAPTVFDGDEQARARPIAPLLDALRS
: :*********** **:*** ****:*** ***:***:.**
Mflv_4695|M.gilvum_PYR-GCK LGVDIDGDGLPFAVRGTGTVAGGTVEIDASGSSQFVSGLLLSGAAFTDGL
Mvan_1771|M.vanbaalenii_PYR-1 LGVAIDGDGLPFSVRGQGSVRGGTVEIDASGSSQFVSGLLLSGAAFTEGL
TH_0661|M.thermoresistible__bu LGVQIEGDGLPFRVHGRGEVIGGTVEIDASASSQFVSGLLLSGAAFRDGL
MUL_2560|M.ulcerans_Agy99 LGVPVDGAGLPFRVQGTGSVAGGTVAIDASASSQFVSGLLLSGASFTDGL
MMAR_1320|M.marinum_M LGVPVDGAGLPFRVQGTGSVAGGTVAIDASASSQFVSGLLLSGASFTDGL
Mb3256|M.bovis_AF2122/97 LGVAVDGTGLPFRVHGNGSLAGGTVAIDASASSQFVSGLLLSAASFTDGL
Rv3227|M.tuberculosis_H37Rv LGVAVDGTGLPFRVRGNGSLAGGTVAIDASASSQFVSGLLLSAASFTDGL
MLBr_00792|M.leprae_Br4923 LGVPVDGVGLPFQVQGSGSVAGGTVAIDASASSQFVSGLLLCAASFTQGV
MAV_4182|M.avium_104 LGVRIEGTALPFRVHGGGALAGGTVAIDASASSQFVSGLLLCAASFTEGL
MSMEG_1890|M.smegmatis_MC2_155 LGVRLDGDGLPFTVRGTGTVSGGTVEIDASGSSQFVSGLLLSGAGFENGL
MAB_3546|M.abscessus_ATCC_1997 TGVGIDGQHLPFTVTGTGQVQGGEVGVDASGSSQFVSGLLLSGAAFSAGL
** ::* *** * * * : ** * :***.**********..*.* *:
Mflv_4695|M.gilvum_PYR-GCK TIVHTGDSVPSAPHIAMTVSMLRDAGVEVDDSAPDRWRVSPGPIGARDWV
Mvan_1771|M.vanbaalenii_PYR-1 TVVHTGGAVPSAPHIAMTVSMLRDAGVEVDDSAADRWRVAPGPIAARHWA
TH_0661|M.thermoresistible__bu TVVHTGDSVPSAPHVAMTVAMLRQAGVDVDDSRPSRWRVAPGPVAARHWV
MUL_2560|M.ulcerans_Agy99 TVQHTGSELPSAPHIAMTVQMLRQAGVDVDDSIPNRWLVRPGALRPRHWD
MMAR_1320|M.marinum_M TVQHTGSELPSAPHIAMTVQMLRQAGVDVDDSIPNRWLVRPGALRPRHWD
Mb3256|M.bovis_AF2122/97 TVQHTGSSLPSAPHIAMTAAMLRQAGVDIDDSTPNRWQVRPGPVAARRWD
Rv3227|M.tuberculosis_H37Rv TVQHTGSSLPSAPHIAMTAAMLRQAGVDIDDSTPNRWQVRPGPVAARRWD
MLBr_00792|M.leprae_Br4923 TVQHTGSPVPSAPHIAMTVMMLRQAGVQVDDSVGNRWQVRPGTVAARHWV
MAV_4182|M.avium_104 TVQHTGAALPSAPHIAMTVAMLRQAGVDVDDSVPNRWQVRPGPVAARHWE
MSMEG_1890|M.smegmatis_MC2_155 TIVHTGVSVPSAPHVAMTVAMLRDAGVEVDDSVANRWQVNPGPVAARSWN
MAB_3546|M.abscessus_ATCC_1997 TAMNTADVLPSGPHVVMTVTMLREAGIAVDDSVPGRWRIDPQPIPAHQWV
* :*. :**.**:.**. ***:**: :*** .** : * .: .: *
Mflv_4695|M.gilvum_PYR-GCK IEPDLSNSVPFLAAAVVSGGAVRITGWPTVSIQPADTILKILAGLNGEVR
Mvan_1771|M.vanbaalenii_PYR-1 VEPDLSNAVPFLAAAVISGGTVRVTGWPTVSTQPAATILSLLTSLGSEVR
TH_0661|M.thermoresistible__bu IEPDLSNAVPFLSAAVVSGGSVRVMGWPASSIQPADIVVNLLKKLDSVVL
MUL_2560|M.ulcerans_Agy99 AEPDLTNAVAFLAAAVVTGGTVTITGWPADSVQPAKNILDILQTLNSTVR
MMAR_1320|M.marinum_M VEPDLTNAVAFLAAAVVTGGTVTITGWPADSVQPAKNILDILQTLNSTVR
Mb3256|M.bovis_AF2122/97 IEPDLTNAVAFLSAAVVSGGTVRITGWPRVSVQPADHILAILRQLNAVVI
Rv3227|M.tuberculosis_H37Rv IEPDLTNAVAFLSAAVVSGGTVRITGWPRVSVQPADHILAILRQLNAVVI
MLBr_00792|M.leprae_Br4923 VEPDLTNAVAFLAAAAVSGGTVRITGWPKTSVQPADNILNILFRLNVVVN
MAV_4182|M.avium_104 VEPDLTNAVPFLAAAVVSGGTVRITGWPADSVQPADNILSVLSKLNAVVS
MSMEG_1890|M.smegmatis_MC2_155 IEPDLSNSTPFLAAALVTGGTVRIAGWPTVSIQPADTILELLATVGGSVR
MAB_3546|M.abscessus_ATCC_1997 IEPDLSNALAFIAPALATGGTVRITGWPRQSTQPARQIEDVVRQFAQTVS
****:*: .*::.* :**:* : *** * *** : :: . *
Mflv_4695|M.gilvum_PYR-GCK KGSSYLEVQGATNYGGIDVDLRDVGELAPSVAAMAALADPGSVSRLRGIA
Mvan_1771|M.vanbaalenii_PYR-1 QGNSHLEVQGATSYDGIDVDLRDVGELAPSVAAMAALASPGSVSRLRGIA
TH_0661|M.thermoresistible__bu RGDSYIEVRGAAQYGGIDADLHDVGELTPAIAALAALAVPGSVSRISGVA
MUL_2560|M.ulcerans_Agy99 HIDSCLQVQGPQSYRGFDVDLRDVGELTPSVAALAALASPGSVSRLAGIA
MMAR_1320|M.marinum_M HIDSCLQVQGPQTYRGFDVDLRDVGELTPSVAALAALASPGSVSRLAGIA
Mb3256|M.bovis_AF2122/97 HADSSLEVRGPTGYDGFDVDLRAVGELTPSVAALAALASPGSVSRLSGIA
Rv3227|M.tuberculosis_H37Rv HADSSLEVRGPTGYDGFDVDLRAVGELTPSVAALAALASPGSVSRLSGIA
MLBr_00792|M.leprae_Br4923 QTDSFLEVQGSTVYDGFDVDLRDVGELTPSVAALAALATPGSVSQLHGIA
MAV_4182|M.avium_104 QTDSSLEVRGSGSYDGFDVDLRAVGELTPSVAALAALATPGSVSRLSGIA
MSMEG_1890|M.smegmatis_MC2_155 EADGHLEVTGAHEYGGFEADLHDVGELAPTVAALAALAKEGSTSQLRGIA
MAB_3546|M.abscessus_ATCC_1997 LTDTHLEVTGQSGYGGVDLDLSEVGELTPTVAALSALAESGAVSTLRGIA
. ::* * * *.: ** ****:*::**::*** *:.* : *:*
Mflv_4695|M.gilvum_PYR-GCK HLRGHETDRLAALSTEINGIGGQCEETEDGLVITAREMHGGTWSSYADHR
Mvan_1771|M.vanbaalenii_PYR-1 HLRGHETDRLAALSAELNRLGGQCEETDDGLVITARQMHGGVWRSYADHR
TH_0661|M.thermoresistible__bu HLRGHETDRLAALSTEINRLGGQCEETDDGLVITARPMHGGRWQSYADHR
MUL_2560|M.ulcerans_Agy99 HLRGHETDRLAALSTEINRLGGNCEQTSDGLVITATPLRPGSWRAYADHR
MMAR_1320|M.marinum_M HLRGHETDRLAALSTEINRLGGNCEQTSDGLVITATPLRPGSWRAYADHR
Mb3256|M.bovis_AF2122/97 HLRGHETDRLAALSTEINRLGGTCRETPDGLVITATPLRPGIWRAYADHR
Rv3227|M.tuberculosis_H37Rv HLRGHETDRLAALSTEINRLGGTCRETPDGLVITATPLRPGIWRAYADHR
MLBr_00792|M.leprae_Br4923 HLRGHETDRLAALSTEINRLGGDCQETSDGLIITATPLRPGVWRAYADHR
MAV_4182|M.avium_104 HLRGHETDRLAALSAEINRLGGDCTETPDGLVITATPLHSGVWQAYADHR
MSMEG_1890|M.smegmatis_MC2_155 HLRGHETDRLAALTTEINGLGGDCRETDDGLLITARPLHGGTWRSYADHR
MAB_3546|M.abscessus_ATCC_1997 HLRGHETDRLKALAHEINALGGRCEETQDGLRIVATDLRGGVWGSYADHR
********** **: *:* :** * :* *** *.* :: * * :*****
Mflv_4695|M.gilvum_PYR-GCK MATAGAIIGLRVPGIEVEDIGTTAKTLPDFPQLWADMLGGQTDDLQ----
Mvan_1771|M.vanbaalenii_PYR-1 MATAGAIVGLRVPGVEVEDIGTTAKTLPDFPQLWADMLAGQTDLQA----
TH_0661|M.thermoresistible__bu MAMAGAIIGLRVPGVEIEDIGTTAKTLPEFPQLWAAMLAGQDTRDV----
MUL_2560|M.ulcerans_Agy99 MAMAGAIVGLRVAGVEVDDIGATSKTLPEFPQLWTEMVE-----------
MMAR_1320|M.marinum_M MAMAGAIVGLRVAGVEVDDIGATSKTLPEFPQLWTEMVE-----------
Mb3256|M.bovis_AF2122/97 MAMAGAIIGLRVAGVEVDDIAATTKTLPEFPRLWAEMVGPGQGWGYPQPR
Rv3227|M.tuberculosis_H37Rv MAMAGAIIGLRVAGVEVDDIAATTKTLPEFPRLWAEMVGPGQGWGYPQPR
MLBr_00792|M.leprae_Br4923 MAMAGAIVGLRVSGVEVDDIGATHKTLPQFPQLWANMLK-----------
MAV_4182|M.avium_104 MAMAGAIVGLRVAGVRVDDIGATGKTLPDFPRLWARMLDTSLPDG-----
MSMEG_1890|M.smegmatis_MC2_155 MATAGAIVGLRVPGVVVENIETTAKTLPDFPSMWVDMLAGE---------
MAB_3546|M.abscessus_ATCC_1997 MATAGALVGLKVPGVSVDDIATTSKTLPDFPGMWADMIAQS---------
** ***::**:*.*: :::* :* ****:** :*. *:
Mflv_4695|M.gilvum_PYR-GCK ---------QGPSARETPGR
Mvan_1771|M.vanbaalenii_PYR-1 ---------GAPHAGRNQGR
TH_0661|M.thermoresistible__bu ---------DMPGGGA----
MUL_2560|M.ulcerans_Agy99 -----------GSSG-----
MMAR_1320|M.marinum_M -----------GSSG-----
Mb3256|M.bovis_AF2122/97 SGQRARRATGQGSGG-----
Rv3227|M.tuberculosis_H37Rv SGQRARRATGQGSGG-----
MLBr_00792|M.leprae_Br4923 -----------RSTG-----
MAV_4182|M.avium_104 -----------EEHGM----
MSMEG_1890|M.smegmatis_MC2_155 -----------PGRNQQR--
MAB_3546|M.abscessus_ATCC_1997 -----------ERAS-----