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M. tuberculosis H37Rv Rv3048c (nrdF)

annotation: ribonucleotide-diphosphate reductase subunit beta
coordinates: 3408404 - 3409378
length: 324

TGNAKLIDRVSAINWNRLQDEKDAEVWDRLTGNFWLPEKVPVSNDIPSWGTLTAGEKQLTMRVFTGLTML
DTIQGTVGAVSLIPDALTPHEEAVLTNIAFMESVHAKSYSQIFSTLCSTAEIDDAFRWSEENRNLQRKAE
IVLQYYRGDEPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVHGYYIGYKFQRG
LALVDDVTRAELKDYTYELLFELYDNEVEYTQDLYDEVGLTEDVKKFLRYNANKALMNLGYEALFPRDET
DVNPAILSALSPNADENHDFFSGSGSSYVIGKAVVTEDDDWDF*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv3048c nrdF - 100% (324) ribonucleotide-diphosphate reductase subunit beta
M. tuberculosis H37Rv Rv1981c nrdF1 e-136 71.16% (319) ribonucleotide-diphosphate reductase subunit beta

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3074c nrdF2 0.0 100.00% (324) ribonucleotide-diphosphate reductase subunit beta
M. gilvum PYR-GCK Mflv_4286 nrdF 1e-178 94.67% (319) ribonucleotide-diphosphate reductase subunit beta
M. leprae Br4923 MLBr_01731 nrdF 1e-179 93.52% (324) ribonucleotide-diphosphate reductase subunit beta
M. abscessus ATCC 19977 MAB_3404c nrdF 1e-170 88.89% (324) ribonucleotide-diphosphate reductase subunit beta
M. marinum M MMAR_1647 nrdF 0.0 96.30% (324) ribonucleoside-diphosphate reductase (beta chain) NrdF2
M. avium 104 MAV_3913 nrdF 1e-178 93.21% (324) ribonucleotide-diphosphate reductase subunit beta
M. smegmatis MC2 155 MSMEG_2313 nrdF2 1e-174 92.28% (324) ribonucleotide-diphosphate reductase subunit beta
M. thermoresistible (build 8) TH_1825 nrdG 1e-174 91.05% (324) RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF2
M. ulcerans Agy99 MUL_1883 nrdF 0.0 95.99% (324) ribonucleotide-diphosphate reductase subunit beta
M. vanbaalenii PYR-1 Mvan_2060 nrdF 1e-176 92.90% (324) ribonucleotide-diphosphate reductase subunit beta

CLUSTAL 2.0.9 multiple sequence alignment


Rv3048c|M.tuberculosis_H37Rv        -------------MTGNAKLIDRVSAINWNRLQDEKDAEVWDRLTGNFWL
Mb3074c|M.bovis_AF2122/97           -------------MTGNAKLIDRVSAINWNRLQDEKDAEVWDRLTGNFWL
MMAR_1647|M.marinum_M               -------------MTGNAKLIDRVSAINWNRVQDEKDAEVWDRLTGNFWL
MUL_1883|M.ulcerans_Agy99           -------------MTGNAKLIDRVSAINWNRVQDEKDAEVWDRLTGNFWL
MLBr_01731|M.leprae_Br4923          ------------MLTGKMKLIDRVSAINWNWLQDDKDAEVWDRLTGNFWL
Mflv_4286|M.gilvum_PYR-GCK          -----------------MKLIDRVSAINWNRLQDDKDAEVWDRLTGNFWL
Mvan_2060|M.vanbaalenii_PYR-1       -------------MSDGMKLIDRVSAINWNRLQDDKDAEVWERLTGNFWL
MAV_3913|M.avium_104                -------------MSENMKLIDRLSAINWNRLQDDKDAEVWDRLTGNFWL
MSMEG_2313|M.smegmatis_MC2_155      -------------MSDGIKLIDRVSAINWNRLQDEKDAEVWHRLTGNFWL
TH_1825|M.thermoresistible__bu      VFGYNVPTSEVGTVSEGMKLVNRVSAINWNRLEDDKDAEVWHRLTGNFWL
MAB_3404c|M.abscessus_ATCC_199      -------------MSEKLKLVSRVSAINWNRVPDEKDAEVWDRLTGNFWL
                                                      **:.*:****** : *:******.********

Rv3048c|M.tuberculosis_H37Rv        PEKVPVSNDIPSWGTLTAGEKQLTMRVFTGLTMLDTIQGTVGAVSLIPDA
Mb3074c|M.bovis_AF2122/97           PEKVPVSNDIPSWGTLTAGEKQLTMRVFTGLTMLDTIQGTVGAVSLIPDA
MMAR_1647|M.marinum_M               PEKVPVSNDIPSWGTLTAGEKQLTMRVFTGLTMLDTIQGTVGAVSLIPDA
MUL_1883|M.ulcerans_Agy99           PEKVPVSNDIPSWGTLTAGEKQLTMRVFTGLTMLDTIQGTVGAVSLIPDA
MLBr_01731|M.leprae_Br4923          PEKVPVSNDLPSWGTLTASEKQLTMRVFTGLTLLDTIQGTVGAVSLIPDA
Mflv_4286|M.gilvum_PYR-GCK          PEKVPVSNDIPSWNTLTAHEKQLTMRVFTGLTLLDTIQGTVGAVSLIPDA
Mvan_2060|M.vanbaalenii_PYR-1       PEKVPVSNDIPSWNTLTAHEKQLTMRVFTGLTLLDTIQGTVGAVSLIPDA
MAV_3913|M.avium_104                PEKVPVSNDLQSWATLTAHEKQMTMRVFTGLTLLDTIQGTVGAVSLIPDA
MSMEG_2313|M.smegmatis_MC2_155      PEKVPVSNDIQSWHTLTDNEKQLTMRVFTGLTLLDTIQGTVGAVSLIPDA
TH_1825|M.thermoresistible__bu      PEKVPVSNDIPSWNTLTDTEKQLTMRVFTGLTLLDTIQGTVGAVSLIPDA
MAB_3404c|M.abscessus_ATCC_199      PEKVPVSNDIQSWNTLTDHEKQLTMRVFTGLTLLDTIQGTVGAVSLIPDA
                                    *********: ** ***  ***:*********:*****************

Rv3048c|M.tuberculosis_H37Rv        LTPHEEAVLTNIAFMESVHAKSYSQIFSTLCSTAEIDDAFRWSEENRNLQ
Mb3074c|M.bovis_AF2122/97           LTPHEEAVLTNIAFMESVHAKSYSQIFSTLCSTAEIDDAFRWSEENRNLQ
MMAR_1647|M.marinum_M               LTPHEEAVLTNIAFMESVHAKSYSQIFSTLCSTAEIDDAFRWSEENSNLQ
MUL_1883|M.ulcerans_Agy99           LTPHEEAVLTNIAFMESVHAKSYSQIFSTLCSTAEIDDAFRWSEENSNLQ
MLBr_01731|M.leprae_Br4923          LTPHEEAVYTNIAFMESVHAKSYSSIFSTLCSTAEIDEAFRWSEENNNLQ
Mflv_4286|M.gilvum_PYR-GCK          LTPHEEAVYTNIAFMESVHARSYSNIFSTLCSTSEIDDAFRWSEENPNLQ
Mvan_2060|M.vanbaalenii_PYR-1       LTPHEEAVYTNIAFMESVHARSYSNIFSTLCSTAEIDDAFRWSEENPNLQ
MAV_3913|M.avium_104                LTPHEEAVYTNIAFMESVHARSYSNIFSTLCSTAEIDDAFRWSEENPNLQ
MSMEG_2313|M.smegmatis_MC2_155      VTPHEEAVLTNIAFMESVHAKSYSNIFSTLCSTAEIDDAFRWSEENPNLQ
TH_1825|M.thermoresistible__bu      LTPHEEAVLTNIAFMESVHAKSYSNIFSTLCSTAEIDDAFRWSEENPNLQ
MAB_3404c|M.abscessus_ATCC_199      ITPHEEAVYTNIAFMESVHAKSYSSIFSTLCSTREIDDAFRWSEENPNLQ
                                    :******* ***********:***.******** ***:******** ***

Rv3048c|M.tuberculosis_H37Rv        RKAEIVLQYYRGDEPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTA
Mb3074c|M.bovis_AF2122/97           RKAEIVLQYYRGDEPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTA
MMAR_1647|M.marinum_M               RKAEIVLEYYRGDDPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTA
MUL_1883|M.ulcerans_Agy99           RKAEIVLEYYRGDDPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTA
MLBr_01731|M.leprae_Br4923          RKAKIVMEYYRGDEPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTA
Mflv_4286|M.gilvum_PYR-GCK          RKAEIVMQYYKGDEPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTA
Mvan_2060|M.vanbaalenii_PYR-1       RKAEIVMQYYKGDEPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTA
MAV_3913|M.avium_104                RKAEIVMQYYKGDEPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTA
MSMEG_2313|M.smegmatis_MC2_155      RKAAIVMQYYRGDEPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTA
TH_1825|M.thermoresistible__bu      RKAEIVMQYYRGDEPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTA
MAB_3404c|M.abscessus_ATCC_199      RKAEIVMEYYRGDEPLKRKVASTLLESFLFYSGFYLPMYWSSRAKLTNTA
                                    *** **::**:**:************************************

Rv3048c|M.tuberculosis_H37Rv        DMIRLIIRDEAVHGYYIGYKFQRGLALVDDVTRAELKDYTYELLFELYDN
Mb3074c|M.bovis_AF2122/97           DMIRLIIRDEAVHGYYIGYKFQRGLALVDDVTRAELKDYTYELLFELYDN
MMAR_1647|M.marinum_M               DMIRLIIRDEAVHGYYIGYKFQRGLAAADEARRTELKDYTYELLFELYDN
MUL_1883|M.ulcerans_Agy99           DMIRLIIRDEAVHGYYIGYKFQRGLAAADEARRTELKDYTYELLFELYDN
MLBr_01731|M.leprae_Br4923          DMIRLIIRDEAVHGYYIGYKFQRGLVLVDDARRAELKEYTYELLFELYDN
Mflv_4286|M.gilvum_PYR-GCK          DMIRLIIRDEAVHGYYIGYKFQKGLALADDATRQELKDYTYELLFELYDN
Mvan_2060|M.vanbaalenii_PYR-1       DMIRLIIRDEAVHGYYIGYKFQKGLALESEATRQELKDYTYELLFELYDN
MAV_3913|M.avium_104                DMIRLIIRDEAVHGYYIGYKYQRGLALVDDAKRQELKDYTYELLFELYDN
MSMEG_2313|M.smegmatis_MC2_155      DMIRLIIRDEAVHGYYIGYKYQRGLALVDEEKKQELKDYTYELLFELYDN
TH_1825|M.thermoresistible__bu      DMIRLIIRDEAVHGYYIGYKYQRGLAMVEPAKQKELKDYTYDLLFELYDN
MAB_3404c|M.abscessus_ATCC_199      DMIRLIIRDEAVHGYYIGYKFQRGLERVDEAKRAEIKEYTYDLLYELYEN
                                    ********************:*:**   .   : *:*:***:**:***:*

Rv3048c|M.tuberculosis_H37Rv        EVEYTQDLYDEVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAI
Mb3074c|M.bovis_AF2122/97           EVEYTQDLYDEVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAI
MMAR_1647|M.marinum_M               EVEYTQDLYDEVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAI
MUL_1883|M.ulcerans_Agy99           EVEYTQDLYDEVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAI
MLBr_01731|M.leprae_Br4923          EVEYTQDLYDRVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAI
Mflv_4286|M.gilvum_PYR-GCK          EVEYTQDLYDEVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAI
Mvan_2060|M.vanbaalenii_PYR-1       EVEYTQDLYDEVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAI
MAV_3913|M.avium_104                EVEYTQDLYDEVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAI
MSMEG_2313|M.smegmatis_MC2_155      EVEYTQDLYDSVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAI
TH_1825|M.thermoresistible__bu      EVEYTQDLYDDVGLTEDVKKFLRYNANKALMNLGYEALFPKDETDVNPAI
MAB_3404c|M.abscessus_ATCC_199      ETDYTEDLYDEVGLTEDVKKFLRYNANKALMNLGYEALFPREETDVNPAI
                                    *.:**:**** *****************************::********

Rv3048c|M.tuberculosis_H37Rv        LSALSPNADENHDFFSGSGSSYVIGKAVVTEDDDWDF
Mb3074c|M.bovis_AF2122/97           LSALSPNADENHDFFSGSGSSYVIGKAVVTEDDDWDF
MMAR_1647|M.marinum_M               LSALSPNADENHDFFSGSGSSYVIGKAVVTQDEDWDF
MUL_1883|M.ulcerans_Agy99           LSALSPNADENHDFFSGSGSSYVIGKAVATQDEDWDF
MLBr_01731|M.leprae_Br4923          LSALSPNADENHDFFSGSGSSYVIGKAVVTEDEDWDF
Mflv_4286|M.gilvum_PYR-GCK          LSALSPNADENHDFFSGSGSSYVIGKAVITEDEDWDF
Mvan_2060|M.vanbaalenii_PYR-1       LSALSPNADENHDFFSGSGSSYVIGKAVNTEDEDWDF
MAV_3913|M.avium_104                LSALSPNADENHDFFSGSGSSYVIGKAVVTEDEDWDF
MSMEG_2313|M.smegmatis_MC2_155      LSALAPNADENHDFFSGSGSSYVIGKAVNTEDEDWDF
TH_1825|M.thermoresistible__bu      LSALAPNADENHDFFSGSGSSYVIGKAVVTEDEDWDF
MAB_3404c|M.abscessus_ATCC_199      LSALSPNADENHDFFSGSGSSYVIGKAVNTEDEDWDF
                                    ****:*********************** *:*:****

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv3048c	nrdF	-	100% (324)	ribonucleotide-diphosphate reductase subunit beta
M. tuberculosis H37Rv	Rv1981c	nrdF1	e-136	71.16% (319)	ribonucleotide-diphosphate reductase subunit beta