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TVGLGMPQPPAPTLAPRRATRQLMVGNVGVGSDHPVSVQSMCTTKTHDVNSTLQQIAELTAAGCDIVRVA CPRQEDADALAEIARHSQIPVVADIHFQPRYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAGAAGIP IRIGVNAGSLDKRFMEKYGKATPEALVESALWEASLFEEHGFGDIKISVKHNDPVVMVAAYELLAARCDY PLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVSLSAPPVEEVKVGNQVLESLNLRPRSLEIVSCP SCGRAQVDVYTLANEVTAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVRGEVIKTVPE AQIVETLIEEAMRLAAEMGEQDPGATPSGSPIVTVS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2868c | ispG | - | 100% (387) | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2893c | ispG | 0.0 | 99.74% (387) | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase |
| M. gilvum PYR-GCK | Mflv_4081 | ispG | 0.0 | 87.79% (385) | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase |
| M. leprae Br4923 | MLBr_01581 | ispG | 0.0 | 86.99% (392) | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase |
| M. abscessus ATCC 19977 | MAB_3169c | ispG | 0.0 | 87.76% (392) | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase |
| M. marinum M | MMAR_1838 | ispG | 0.0 | 94.32% (387) | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, IspG |
| M. avium 104 | MAV_3725 | ispG | 0.0 | 93.13% (364) | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase |
| M. smegmatis MC2 155 | MSMEG_2580 | ispG | 0.0 | 90.67% (386) | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase |
| M. thermoresistible (build 8) | TH_1399 | gcpE | 0.0 | 88.78% (392) | PROBABLE GCPE PROTEIN |
| M. ulcerans Agy99 | MUL_2087 | ispG | 0.0 | 95.04% (363) | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase |
| M. vanbaalenii PYR-1 | Mvan_2262 | ispG | 0.0 | 88.46% (390) | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2868c|M.tuberculosis_H37Rv -MT---VGLGMPQP----PAPTLAPRRATRQLMVGNVGVGSDHPVSVQSM
Mb2893c|M.bovis_AF2122/97 -MT---VGLGMPQP----PAPTLAPRRATRQLMVGNVGVGSDHPVSVQSM
MMAR_1838|M.marinum_M -MT---TGLGIPQP----PAPTLSPRRTTRQLMVRDVGVGSDYPVSVQSM
MUL_2087|M.ulcerans_Agy99 --------------------------------MVRDVGVGSDYPVSVQSM
MLBr_01581|M.leprae_Br4923 -MN---MRLGMPEA----PAPGLAPRRITRQLMVGNVGVGSDHQISVQSM
MAV_3725|M.avium_104 --------------------------------MVRDVGVGSDYPISVQSM
TH_1399|M.thermoresistible__bu MTS---IGLGMPAVGSGGPAPVLAPRRKTRQLMVCDVGVGSDHPISVQSM
Mflv_4081|M.gilvum_PYR-GCK MTSTAGVGLGMPAPP----PPVLAPRRKTRQLMVGDVGVGSDHPIAVQSM
Mvan_2262|M.vanbaalenii_PYR-1 MTS---IGLGIPAPP----APVLAPRRKTRQLMVRDVGVGSDHPISVQSM
MSMEG_2580|M.smegmatis_MC2_155 MTS---IGLGMPAPP----APTLAPRRKTRQLNVGGVGIGSEHPIAVQSM
MAB_3169c|M.abscessus_ATCC_199 MMT----GLGMPSLPGA-PPPTLAPRRQTRQLMVGSVGVGSDSPVSVQSM
* .**:**: ::****
Rv2868c|M.tuberculosis_H37Rv CTTKTHDVNSTLQQIAELTAAGCDIVRVACPRQEDADALAEIARHSQIPV
Mb2893c|M.bovis_AF2122/97 CTTKTHDVNSTLQQIAELTAAGCDIVRVACPRQEDADALAEIARHSQIPV
MMAR_1838|M.marinum_M CTTKTHDVNATLQQIAELTAAGCDIVRVACPRQEDADALAEIARHSQIPV
MUL_2087|M.ulcerans_Agy99 CTTKTHDVNATLQQIAELTAAGCDIVRVACPRQEDADALAEIARHSQIPV
MLBr_01581|M.leprae_Br4923 CITKTHDVNATLQQIAELTTAGCDIVRVACPRQEDADALAEIARHSKIPV
MAV_3725|M.avium_104 CTTKTHDVNSTLQQIAELTAAGCDIVRVACPRQEDADALAEIARHSQIPV
TH_1399|M.thermoresistible__bu CTTKTHDVNATLQQIAELTAAGCDIVRVACPRQEDADALPAIAAKSKIPV
Mflv_4081|M.gilvum_PYR-GCK CTTKTHDINATLQQIAELTASGCDIVRVACPRQEDADALPAIAKKANIPV
Mvan_2262|M.vanbaalenii_PYR-1 CTTKTHDINATLQQIAELTASGCDIVRVACPRQEDADALPIIAKKSKIPV
MSMEG_2580|M.smegmatis_MC2_155 CTTKTHDVNSTLQQIAELTASGCDIVRVACPRQEDADALAEIARHSQIPV
MAB_3169c|M.abscessus_ATCC_199 CTTKTHDVNSTLQQIAELTASGCDIVRVACPRQEDADALAEIARKSKIPV
* *****:*:*********::******************. ** :::***
Rv2868c|M.tuberculosis_H37Rv VADIHFQPRYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAGAAGIPI
Mb2893c|M.bovis_AF2122/97 VADIHFQPRYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAGAAGIPI
MMAR_1838|M.marinum_M IADIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAGAAGIPI
MUL_2087|M.ulcerans_Agy99 AADIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAGAAGIPI
MLBr_01581|M.leprae_Br4923 IVDIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAAAAGIPI
MAV_3725|M.avium_104 IADIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAAAAGIPI
TH_1399|M.thermoresistible__bu IADIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVKEVAKAAGDAGIPI
Mflv_4081|M.gilvum_PYR-GCK IADIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVKEVAKAAGDAGIPI
Mvan_2262|M.vanbaalenii_PYR-1 IADIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVAEVAKAAGDAGIPI
MSMEG_2580|M.smegmatis_MC2_155 IADIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVKEVAKAAGDAGIPI
MAB_3169c|M.abscessus_ATCC_199 IADIHFQPKYIFAAIDAGCAAVRVNPGNIKEFDGRVKEVAKAAGDAGIPI
.******:*************************** ******. *****
Rv2868c|M.tuberculosis_H37Rv RIGVNAGSLDKRFMEKYGKATPEALVESALWEASLFEEHGFGDIKISVKH
Mb2893c|M.bovis_AF2122/97 RIGVNAGSLDKRFMEKYGKATPEALVESALWEASLFEEHGFGDIKISVKH
MMAR_1838|M.marinum_M RIGVNAGSLDKRFMQKYGKATPEALVESALWEASLFEEHGFGNIKISVKH
MUL_2087|M.ulcerans_Agy99 RIGVNAGSLDKRFMQKYGKATPEALVESALWEASLFEEHGFGNIKISVKH
MLBr_01581|M.leprae_Br4923 RIGVNAGSLDKRFMDKYGKATSEALVESALWEASLFEEHGFGNIKISVKH
MAV_3725|M.avium_104 RIGVNAGSLDKRFMAKYGKATPEALVESALWEASLFEEHGFSDIKISVKH
TH_1399|M.thermoresistible__bu RIGVNAGSLDKRFMQKYGKATPEALVESALWEASLFEEHGFGDIKISVKH
Mflv_4081|M.gilvum_PYR-GCK RIGVNAGSLDPRILKKYGKATPEALVESAMWEASLFEEHGFGDIKISVKH
Mvan_2262|M.vanbaalenii_PYR-1 RIGVNAGSLDKRFLEKYGKATPEALVESALWEASLFEEHGFGNIKISVKH
MSMEG_2580|M.smegmatis_MC2_155 RIGVNAGSLDKRFLEKYGKATPEALVESALWEASLFEEHGFGDIKISVKH
MAB_3169c|M.abscessus_ATCC_199 RIGVNAGSLDPRILGKYGKATPEALVESALWEAGLFEEHGFGDIKISVKH
********** *:: ******.*******:***.*******.:*******
Rv2868c|M.tuberculosis_H37Rv NDPVVMVAAYELLAARCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGI
Mb2893c|M.bovis_AF2122/97 NDPVVMVAAYELLAARCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGI
MMAR_1838|M.marinum_M NDPVIMVAAYEQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGI
MUL_2087|M.ulcerans_Agy99 NDPVIMVAAYEQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGI
MLBr_01581|M.leprae_Br4923 HDPVVMVAAYEQLAAQCDYPLHLGVTEAGPVFQGTVKSAVAFGALLSKGI
MAV_3725|M.avium_104 NDPVVMVAAYEQLAEQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGI
TH_1399|M.thermoresistible__bu SDPVVMVQAYEMLAEQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGI
Mflv_4081|M.gilvum_PYR-GCK NDPVIMVAAYEQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSKGI
Mvan_2262|M.vanbaalenii_PYR-1 NDPVVMVAAYEQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSKGI
MSMEG_2580|M.smegmatis_MC2_155 NDPVIMVAAYEQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSKGI
MAB_3169c|M.abscessus_ATCC_199 NDPVIMVAAYELLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSKGI
***:** *** ** :**************.****:***********:**
Rv2868c|M.tuberculosis_H37Rv GDTIRVSLSAPPVEEVKVGNQVLESLNLRPRSLEIVSCPSCGRAQVDVYT
Mb2893c|M.bovis_AF2122/97 GDTIRVSLSAPPVEEVKVGNQVLESLNLRPRSLEIVSCPSCGRAQVDVYT
MMAR_1838|M.marinum_M GDTIRVSLSAPPVEEVKVGNQILESLNLRPRSLEIVSCPSCGRAQVDVYT
MUL_2087|M.ulcerans_Agy99 GDTIRVSLSAPPVEEVKVGNQILESLNLRPRSLEIVSCPSCGRAQVDVYT
MLBr_01581|M.leprae_Br4923 GDTIRVSLSAPPVEEIKVGNQILESLNLRPRSHEIVSCPSCGRAQVDVYK
MAV_3725|M.avium_104 GDTIRVSLSAPPVEEVKVGIQILESLNLRPRSLEIVSCPSCGRAQVDVYT
TH_1399|M.thermoresistible__bu GDTIRVSLSAPPVEEVKVGVQILESLNLRPRGLEIVSCPSCGRAQVDVYT
Mflv_4081|M.gilvum_PYR-GCK GDTIRVSLSAPPAEEVKVGNQILESLNLRPRGLEIVSCPSCGRAQVDVYT
Mvan_2262|M.vanbaalenii_PYR-1 GDTIRVSLSAPPAEEVKVGNQILESLNLRPRGLEIVSCPSCGRAQVDVYT
MSMEG_2580|M.smegmatis_MC2_155 GDTIRVSLSAPPAEEVKVGNQILESLNLRPRGLEIVSCPSCGRAQVDVYT
MAB_3169c|M.abscessus_ATCC_199 GDTIRVSLSAPPAEEVKVGNQILESLNLRPRSLEIVSCPSCGRAQVDVYT
************.**:*** *:*********. ****************.
Rv2868c|M.tuberculosis_H37Rv LANEVTAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVR
Mb2893c|M.bovis_AF2122/97 LANEVTAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVR
MMAR_1838|M.marinum_M LANEVTAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVR
MUL_2087|M.ulcerans_Agy99 LANEVTAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVR
MLBr_01581|M.leprae_Br4923 LANEVSAGLDGLEVPLRIAVMGCVVNGPGEARDADLGVASGNGKGQIFVK
MAV_3725|M.avium_104 LANEVSAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVR
TH_1399|M.thermoresistible__bu LANEVTAGLEGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVK
Mflv_4081|M.gilvum_PYR-GCK LANEVTAGLEGLEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVK
Mvan_2262|M.vanbaalenii_PYR-1 LANEVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVK
MSMEG_2580|M.smegmatis_MC2_155 LANAVTAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVK
MAB_3169c|M.abscessus_ATCC_199 LANAVSAGLEGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVK
*** *:***:*::****:**************:****************:
Rv2868c|M.tuberculosis_H37Rv GEVIKTVPEAQIVETLIEEAMRLAAEMGEQDPG-----ATPSGSPIVTVS
Mb2893c|M.bovis_AF2122/97 GEVIKTVPEAQIVETLIEEAMRLAAEMGEQAPG-----ATPSGSPIVTVS
MMAR_1838|M.marinum_M GEVIKTVPEAQIVETLIEEAMRIAAEMGTEDPG-----TTSSGTPIVTVS
MUL_2087|M.ulcerans_Agy99 GEVIKTVPEAQIVETLIEEAMRIAAEMGTEDPG-----TTSSGAPIVTVS
MLBr_01581|M.leprae_Br4923 GEVIKTVPEAQIVETLIEEAMRLVSEMGTEKGSDHCSETTRSGSPVVTVN
MAV_3725|M.avium_104 GEVIKTVPESQIVETLIEEAMRIAAQMNSEGGP----EATSSGSPVVTVS
TH_1399|M.thermoresistible__bu GEVIKTVPESQIVETLIEEAMRIAAEMGSGDGE---SGPESSGSPIVTVS
Mflv_4081|M.gilvum_PYR-GCK GEVIKTVPEALIVETLIEEAMRLAADMDTTP----GSEEA-SGSPVVTVS
Mvan_2262|M.vanbaalenii_PYR-1 GEVIKTVPEAQIVETLIEEALRLADEMGEAPGDAQGSEGA-TGSPIVTVS
MSMEG_2580|M.smegmatis_MC2_155 GEVIKTVPEAQIVETLIEEAMRLAEEIGTAR----GSDDA-SGSPVVTVS
MAB_3169c|M.abscessus_ATCC_199 GEVIKTVPEALIVETLIDEAMRLAEQMGLENGAGIGSDGTPTGQPVVTVS
*********: ******:**:*:. ::. :* *:***.