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ITRMSELFLRTLRDDPADAEVASHKLLIRAGYIRPVAPGLYSWLPLGLRVLRNIERVIRDEMNAIGGQEI LFPALLPRAPYETTNRWTQYGDSVFRLKDRRGNDYLLGPTHEELFTLTVKGEYSSYKDFPLTLYQIQTKY RDEARPRAGILRAREFVMKDSYSFDIDAAGLKAAYHAHREAYQRIFDRLQVRYVIVSAVSGAMGGSASEE FLAESPSGEDAFVRCLESGYAANVEAVVTARPDTLPIDGLPEAVVHDTGDTPTIASLVAWANEADLGRTV TAADTLKNVLIKVRQPGGDTELLAIGVPGDREVDDKRLGAALEPADYALLDDDDFAKHPFLVKGYIGPKA LRENNVRYLVDPRIVDGTSWITGADQPGRHVVGLVAGRDFTADGTIEAAEVREGDPSPDGAGPLVMARGI EIGHIFQLGSKYTDAFTADVLGEDGKPVRLTMGSYGIGVSRLVAVVAEQHHDELGLRWPSTVAPFDVHLV IANKDAQARAGATALAADLDRLGVEVLLDDRQASPGVKFKDAELLGMPWIVVVGRGWADGVVELRDRFSG QTRELVAGASLATDIAAAVTG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2845c | proS | - | 100% (582) | prolyl-tRNA synthetase |
| M. tuberculosis H37Rv | Rv2614c | thrS | 5e-05 | 24.65% (142) | threonyl-tRNA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2870c | proS | 0.0 | 99.66% (582) | prolyl-tRNA synthetase |
| M. gilvum PYR-GCK | Mflv_4045 | - | 0.0 | 83.33% (588) | prolyl-tRNA synthetase |
| M. leprae Br4923 | MLBr_01553 | proS | 3e-08 | 27.45% (153) | prolyl-tRNA synthetase |
| M. abscessus ATCC 19977 | MAB_3140c | - | 0.0 | 81.93% (581) | prolyl-tRNA synthetase |
| M. marinum M | MMAR_1888 | proS | 0.0 | 89.18% (582) | prolyl-tRNA synthetase ProS |
| M. avium 104 | MAV_3700 | proS | 0.0 | 89.86% (582) | prolyl-tRNA synthetase |
| M. smegmatis MC2 155 | MSMEG_2621 | proS | 0.0 | 81.57% (586) | prolyl-tRNA synthetase |
| M. thermoresistible (build 8) | TH_1980 | proS | 0.0 | 84.08% (584) | PROBABLE PROLYL-TRNA SYNTHETASE PROS (PROLINE--TRNA LIGASE) |
| M. ulcerans Agy99 | MUL_2116 | proS | 0.0 | 89.18% (582) | prolyl-tRNA synthetase |
| M. vanbaalenii PYR-1 | Mvan_2308 | - | 0.0 | 82.94% (586) | prolyl-tRNA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2845c|M.tuberculosis_H37Rv MITRMSELFLRTLRDDPADAEVASHKLLIRAGYIR-PVAPGLYSWLPLGL
Mb2870c|M.bovis_AF2122/97 MITRMSELFLRTLRDDPADAEVASHKLLIRAGYIR-PVAPGLYSWLPLGL
MMAR_1888|M.marinum_M MITRMSELFLRTLRDDPADAEVPSHKLLIRAGYIR-PVGPGLYSWLPLGL
MUL_2116|M.ulcerans_Agy99 MITRMSELFLRTLRDDPADAEVPSHKLLIRAGYIR-PVGPGLYSWLPLGL
MAV_3700|M.avium_104 MITRMSQLFLRTLRDDPADAEVPSHKLLIRAGYIR-PVAPGLYSWLPLGL
MAB_3140c|M.abscessus_ATCC_199 MITRLSELFVRTLRDDPADAEVPSHKLLIRAGYVR-PVAPGVYSWLPLGL
MSMEG_2621|M.smegmatis_MC2_155 MITRMSELFLRTLRDDPADAEVPSHKLLIRAGYVR-AVGPGIYSWLPLGL
TH_1980|M.thermoresistible__bu VITRMSELFLRTLRDDPADAEVPSHKLLIRAGYIR-PVGPGLYSWLPLGL
Mflv_4045|M.gilvum_PYR-GCK MITRMSELFLRTLRDDPADAEVPSHKLLIRAGYVR-PVGPGLYSWLPLGL
Mvan_2308|M.vanbaalenii_PYR-1 MITRMSELFLRTLRDDPADAEVPSHKLLIRAGYVR-PVGPGLYSWLPLGL
MLBr_01553|M.leprae_Br4923 -----MGCNKRGVTRQEDDFSAWYNEVVAKAGLIDRGPAKGTMVIRPYGY
* : : * .. :::: :** : . * * *
Rv2845c|M.tuberculosis_H37Rv RVLRNIERVIRDEMNAIGGQEILFPALLPRAPYETTNRWTQYGDSVFRLK
Mb2870c|M.bovis_AF2122/97 RVLRNIERVIRDEMNAIGGQEILFPALLPRAPYETTNRWTQYGDSVFRLK
MMAR_1888|M.marinum_M RVLRNIERVIREEMNAIGGQEILFPALLPRAPYETTNRWTEYGDGVFRLQ
MUL_2116|M.ulcerans_Agy99 RVLRNIERVIREEMNAIGGQEILFPALLPRAPYETTNRWTEYGDGVFRLE
MAV_3700|M.avium_104 RVLRRIEHIVREEMNAIGGQEILFPALLPRAPYEATNRWTEYGDSVFRLQ
MAB_3140c|M.abscessus_ATCC_199 RVLRKIENIVREEMNAIGGQEILLPALLPRAPYETTNRWTEYGDSLFRLK
MSMEG_2621|M.smegmatis_MC2_155 RVLRKIENVVRSEMNAIGAQEILLPALLPRGPYETTNRWTEYGDTLFRLQ
TH_1980|M.thermoresistible__bu RVLRNIEEIVRQEMVAIGGQEILFPALLPRGPYETTNRWSEYGDTLFRLK
Mflv_4045|M.gilvum_PYR-GCK KVLRKIEHIVRSEMDAIGGQEILFPALLPRAPYETTNRWTEYGDTLFRLQ
Mvan_2308|M.vanbaalenii_PYR-1 KVLRKIENIVRNEMNAIGGQEILFPALLPRAPYETTNRWTEYGDTLFRLQ
MLBr_01553|M.leprae_Br4923 RIWELLQDELDSKIKELGHENAYFPMLIPENYFNREAEHVEGFHPELAVV
:: . :: : .:: :* :: :* *:*. :: . : . : :
Rv2845c|M.tuberculosis_H37Rv DRRGND-----YLLGPTHEELFTLTVKGEYSSYKDFPLTLYQIQTKYRDE
Mb2870c|M.bovis_AF2122/97 DRRGND-----YLLGPTHEELFTLTVKGEYSSYKDFPLTLYQIQTKYRDE
MMAR_1888|M.marinum_M DRRGND-----YLLGPTHEELFTLTVKGEYNSYKDFPLTLYQIQIKYRDE
MUL_2116|M.ulcerans_Agy99 DRRGND-----YLLGPTHEELFTLTVKGEYNSYKDFPLTLYQIQIKYRDE
MAV_3700|M.avium_104 DRRGND-----YLLGPTHEELFTLTVKGEYSSYKDFPVLLYQIQNKYRDE
MAB_3140c|M.abscessus_ATCC_199 DRRDND-----MMLGPTHEELFALTVKGEYSSYKDFPVILYQVQTKYRDE
MSMEG_2621|M.smegmatis_MC2_155 DRRNND-----YLLGPTHEELFTLTVKGEYSSYKDFPVILYQIQTKYRDE
TH_1980|M.thermoresistible__bu DRRDND-----YLLGPTHEELFTLTVKGEYSSYKDFPLLLFQIQTKYRDE
Mflv_4045|M.gilvum_PYR-GCK DRRDND-----YLLGPTHEEMFTLTVKGEYSSYKDFPLRLYQIQNKYRDE
Mvan_2308|M.vanbaalenii_PYR-1 DRRNND-----YLLGPTHEEMFTLTVKGEYSSYKDFPLRLYQIQNKYRDE
MLBr_01553|M.leprae_Br4923 THAGGKELSEPLVIRPTSETVIGDMMAKWITSHRDLPLRLNQWSNVVRWE
: ... :: ** * :: : .*::*:*: * * . * *
Rv2845c|M.tuberculosis_H37Rv ARPRAGILRAREFVMKDSYSFDIDAAGLKAAYHAHREAYQRIFDRLQVRY
Mb2870c|M.bovis_AF2122/97 ARPRAGILRAREFVMKDSYSFDIDAAGLKAAYRAHREAYQRIFDRLQVRY
MMAR_1888|M.marinum_M ARPRAGILRAREFVMKDSYSFDIDSGGLKAAYHAHREAYQRIFDRLRVRY
MUL_2116|M.ulcerans_Agy99 ARPRAGILRAREFVMKDSYSFDIDSGGLKAAYHAHREAYQRIFDRLRVRY
MAV_3700|M.avium_104 ARPRAGILRVREFVMKDSYSFDIDDAGLKAAYHAHREAYQRIFARLQVRY
MAB_3140c|M.abscessus_ATCC_199 ARPRAGILRGREFVMKDSYSFDTSDDGLKAAYHAHRDAYQRIFGRLGLDY
MSMEG_2621|M.smegmatis_MC2_155 ARPRAGILRGREFVMKDSYSFDVDDDGLKNAYYQHREAYQRIFARLGVRY
TH_1980|M.thermoresistible__bu ARPRAGILRGREFVMKDSYSFDVDDAGLKAVYQAHRDAYQRIFDRLGVRY
Mflv_4045|M.gilvum_PYR-GCK ARPRAGILRGREFLMKDSYSFDVDDDGLKNAYHAHREAYQRIFDRLKVRY
Mvan_2308|M.vanbaalenii_PYR-1 ARPRAGILRGREFLMKDSYSFDIDDDGLKNAYIAHREAYQRIFDLLKVRY
MLBr_01553|M.leprae_Br4923 LRPRM-LLRTIEFLWQEGHSAHIE----KSDALRETLFALDIYTTLARDM
*** :** **: ::.:* . . * . *: *
Rv2845c|M.tuberculosis_H37Rv VIVSAVSGAMGGSASEEFLAESPSGEDAFVRCLESGYAANVEAVVTARPD
Mb2870c|M.bovis_AF2122/97 VIVSAVSGAMGGSASEEFLAESPSGEDAFVRCLESGYTANVEAVVTARPD
MMAR_1888|M.marinum_M VIVSAVSGAMGGSASEEFLAESPVGEDTFVRCVESGYAANVEAVVTARPE
MUL_2116|M.ulcerans_Agy99 VIVSAVSGAMGGSASEEFLAESPVGEDTFVRCVESGYAANVEAVVTARPE
MAV_3700|M.avium_104 VIVSAVSGAMGGSASEEFLAESPVGEDTFVRCLESGYAANVEAVITARPD
MAB_3140c|M.abscessus_ATCC_199 VIVAATSGAMGGSASEEFLAESPTGEDTFVRCVESGYAANVEAVITPAPP
MSMEG_2621|M.smegmatis_MC2_155 VIVSAVSGAMGGSASEEFLAESEVGEDTFVRCVESGYAANVEAVITRAPE
TH_1980|M.thermoresistible__bu VIVSAVSGAMGGSASEEFLAESEVGEDTFVRCPESGYAANVEAVVTPAPE
Mflv_4045|M.gilvum_PYR-GCK VIVSAVSGAMGGSASEEFLAESEVGEDTFVRCAQSGYAANVEAVVTTAPD
Mvan_2308|M.vanbaalenii_PYR-1 VIVSAVSGAMGGSASEEFLAESDVGEDTYVRCLQSGYAANVEAVVTMVPE
MLBr_01553|M.leprae_Br4923 AAIPIVSGEK--TAGERFAGALN--------------TYTIEAMMRDG--
. :. .** :*.*.* . : .:**::
Rv2845c|M.tuberculosis_H37Rv TLP---IDGLPEAVVHDTGDTPTIASLVAWANEADL----GRTVTAADTL
Mb2870c|M.bovis_AF2122/97 TLP---IDGLPEAVVHDTGDTPTIASLVAWANEADL----GRTVTAADTL
MMAR_1888|M.marinum_M SLP---IDGQPDAVVHDTGETPTIATLVAWANEAGL----GREVSAADTL
MUL_2116|M.ulcerans_Agy99 SLP---IDGQPDAVVHDTGETPTIATLVAWANEAGL----GREVSAADTL
MAV_3700|M.avium_104 PQP---VEGLPEAVVHDTGDTPTIATLVDWANRAGL----GRTVTAADTL
MAB_3140c|M.abscessus_ATCC_199 ARP---IEGLAEAVVHETGDTPTIATLVDWANSAGL----GRTVTAADTL
MSMEG_2621|M.smegmatis_MC2_155 AQP---TEGLPEAKVYDTPDTPTIATLVEWANSASLPQFEGRTVTAADTL
TH_1980|M.thermoresistible__bu PRP---IDGLPEPKVYDTPDTATIATLVDWANRADLPGFEGREVTAADTL
Mflv_4045|M.gilvum_PYR-GCK PIP---LDGLPEAVVYDTPDTPTIATLVDWANTADLPSFAGRAVTAADTL
Mvan_2308|M.vanbaalenii_PYR-1 PISSEQIAGLASATVHHTGDTPTIATLVDWANGADL----GRTVTAADTL
MLBr_01553|M.leprae_Br4923 -------KALQSATTHYLGDNFARAFNIRYTTAEEQ--------------
. .. .: :. : * : ::.
Rv2845c|M.tuberculosis_H37Rv KNVLIKVRQPGGDTELLAIGVPGDREVDDKRLGAALEPADYALLDDDDFA
Mb2870c|M.bovis_AF2122/97 KNVLIKVRQPGGDTELLAIGVPGDREVDDKRLGAALEPADYALLDDDDFA
MMAR_1888|M.marinum_M KNVLMKIRQPGGEWELLAIGVPGDREIDEKRLAAALDPAEYVFLDDDDFG
MUL_2116|M.ulcerans_Agy99 KNVLMKIRQPGGEWELLAIGVPGDREIDEKRLAAALDPAEYVFLDDDDFG
MAV_3700|M.avium_104 KNVLLKVRQPGGDWELLAIGLPGDREVDDKRLGAALEPAEYVLLDDADFA
MAB_3140c|M.abscessus_ATCC_199 KNILLKVRQPGGDWELLAVGVPGDREVDDKRLGAALEPAEYELLGDADFA
MSMEG_2621|M.smegmatis_MC2_155 KNVLLKTREPGGEWELLAVGVPGDREVDEKRLGAALEPAEFALLDDADFA
TH_1980|M.thermoresistible__bu KNVVLKVREPGGDWELLAIGLPGDREVDDKRLGAALDPAEYEFLDDADFA
Mflv_4045|M.gilvum_PYR-GCK KNVLLKVREPGGDWELLAIGVPGDREVDDKRLGAALDPAEYAMADDADFA
Mvan_2308|M.vanbaalenii_PYR-1 KNVMLKVREPGGEWELLGVGVPGDREVDDKRLGAALEPAEYAMLDDADFA
MLBr_01553|M.leprae_Br4923 -QAFVHTTSFGLSTRMIGAIVMVHGDDKGLVLPPQVAPYQVVIVPITTGN
: .:: . * . .::. : . : . * . : * : :
Rv2845c|M.tuberculosis_H37Rv KHPFLVKGYIG-PKALRENNVRYLVDPRIVDGTSWITGADQPGRHVVGLV
Mb2870c|M.bovis_AF2122/97 KHPFLVKGYIG-PKALRENNVRYLVDPRIVDGTSWITGADQPGRHVVGLV
MMAR_1888|M.marinum_M KYPFLVKGYIG-PKALRSNDVRYLLDPRVVDGTSWITGADEPGRHVVGLV
MUL_2116|M.ulcerans_Agy99 KYPFLVKGYIG-PKALRSNDVRYLLDPRVVDGTSWITGADEPGRHVVGLV
MAV_3700|M.avium_104 RYPFLVKGYIG-PKALKDNGVRYLVDPRVVDGTSWITGADEPGRHVVGLV
MAB_3140c|M.abscessus_ATCC_199 KYPFLVRGYIG-PKALLANGVRYLVDPRVVEGTSWITGADEPGKHVVDLV
MSMEG_2621|M.smegmatis_MC2_155 ANPFLVKGYVG-PKALQDNGVRYLVDPRVVHGSSWITGADAPNRHVVGLV
TH_1980|M.thermoresistible__bu RHPFLAKGYIG-PKALQANGVRYLVDPRVVTGTSWITGADEPGRHVVGLV
Mflv_4045|M.gilvum_PYR-GCK AHPFLKKGYIG-PKALLANGVRYLVDPRVVDGTAWITGADETGRHVVDLV
Mvan_2308|M.vanbaalenii_PYR-1 RYPFLVKGYIG-PKALLANGVRYLVDPRVVDGTAWITGADELGKHVVDLV
MLBr_01553|M.leprae_Br4923 KASEVGHAAADLARRLQAAGVRTHVDARPQLTPGWKYNEWELRGVPIRLE
. : :. . .: * .** :*.* ..* . : *
Rv2845c|M.tuberculosis_H37Rv AGRDFTADGTIEAAEVREGDPSPDGAGPLVMARGIEIGHIFQLGSKYTDA
Mb2870c|M.bovis_AF2122/97 AGRDFTADGTIEAAEVREGDPSPDGAGPLVMARGIEIGHIFQLGSKYTDA
MMAR_1888|M.marinum_M AGRDFTADGTIEAAEVREGDPAPDGAGQLVMARGIEIGHIFQLGRKYTDA
MUL_2116|M.ulcerans_Agy99 AGRDFTADGTIEAAEVREGDPAPDGAGQLVMARGIEIGHIFQLGRKYTDA
MAV_3700|M.avium_104 AGRDFTADGTIEAAEVRDGDPSPDGAGPLVSARGIEVAHIFQLGRKYTDA
MAB_3140c|M.abscessus_ATCC_199 AGRDFTADGTIEAAEVRDGDPSPDGAGQLVSARGIEIGHIFQLGRKYTDA
MSMEG_2621|M.smegmatis_MC2_155 AGRDFTPDGTIEAAEVRDGDPSPDGAGVLTSARGIEIGHIFQLGRKYTDA
TH_1980|M.thermoresistible__bu AGRDFTPDGTIEAAEVRDGDPSPDGAGTLVSARGIEIGHIFQLGRKYTDA
Mflv_4045|M.gilvum_PYR-GCK AGRDFTPDGTIEAAEVREGDPSPDGAGPLVAARGIEIGHVFQLGRKYADA
Mvan_2308|M.vanbaalenii_PYR-1 AGRDFTPDGTIEAAEVREGDPSPDGAGPLVAARGIEIGHVFQLGRKYADA
MLBr_01553|M.leprae_Br4923 LG------------------PRDLEAGTTVMVR--------RIGEKAKQP
* * ** . .* ::* * :.
Rv2845c|M.tuberculosis_H37Rv FTADVLGEDGKPVRLTMGSYGIGVSRLVAVVAEQHHDELGLRWPSTVAPF
Mb2870c|M.bovis_AF2122/97 FTADVLGEDGKPVRLTMGSYGIGVSRLVAVVAEQHHDELGLRWPSTVAPF
MMAR_1888|M.marinum_M FTADVLGEDGKPVRLTMGSYGIGVSRLVAVIAEQHHDNLGLRWPAEIAPF
MUL_2116|M.ulcerans_Agy99 FTADVLGEDGKPVRLTMGSYGIGVSRLVAVIAEQHHDNLGLRWPAEIAPF
MAV_3700|M.avium_104 FTADVLGEDGKPVRLTMGSYGLGVSRMVAVIAEQHHDELGLRWPASVAPF
MAB_3140c|M.abscessus_ATCC_199 FTVDVLGENGKPVRLTQGSYGIGVSRLVAVVAEQQHDELGLRWPSAVSPF
MSMEG_2621|M.smegmatis_MC2_155 FSADVLGEDGKPLRLTMGSYGIGVSRLVAVIAEQQHDQLGLRWPSSVAPF
TH_1980|M.thermoresistible__bu FNVDVLGEDGKPVRLTMGSYGIGVSRLVAVIAEQHHDELGLRWPSSVAPF
Mflv_4045|M.gilvum_PYR-GCK FNADVLGENGKPVRLTMGSYGIGVSRLVAVIAEQHHDELGLRWPGSVAPF
Mvan_2308|M.vanbaalenii_PYR-1 FGADVLGENGKPVRLTMGSYGIGVSRLVAVIAEQHHDELGLRWPSTVSPF
MLBr_01553|M.leprae_Br4923 IAIAAAP-----------------TELPGILEEFQRTLLER---ATQFRD
: . :.: .:: * :: * .
Rv2845c|M.tuberculosis_H37Rv DVHLVIANKDAQARAGATALAADLDRLGVEVLLDDRQASPGVKFKDAELL
Mb2870c|M.bovis_AF2122/97 DVHLVIANKDAQARAGATALAADLDRLGVEVLLDDRQASPGVKFKDAELL
MMAR_1888|M.marinum_M GVHLVIANKDAEARAGAIGLASELDGLGVEVLLDDRQASPGVKFKDAELL
MUL_2116|M.ulcerans_Agy99 GVHLVIANKDAEARAGAIGLAGELDGLGVEVLLDDRQASPGVKFKDAELL
MAV_3700|M.avium_104 DVHLVIANKDAQARAGATALADDLDRLGVEVLLDDRQASPGVKFKDAELL
MAB_3140c|M.abscessus_ATCC_199 DVHVVIANKDDAARAGAEELAAELDRLGHEVLLDDRTASPGVKFKDAELL
MSMEG_2621|M.smegmatis_MC2_155 DVHVVVANKDAGARAGAAELVADLDRLGHEVLFDDRQASPGVKFKDAELL
TH_1980|M.thermoresistible__bu DVHVVIANKDSAARAGAEQLAADLDRLGLQVLLDDRTASPGVKFKDAELL
Mflv_4045|M.gilvum_PYR-GCK AVHVVIANKDAEARAGATELATALDRAGADVLLDDRTASPGVKFKDAELL
Mvan_2308|M.vanbaalenii_PYR-1 DVHVVIANKDADARTGATELAAELDRLGVDVLLDDRTASPGVKFKDAELL
MLBr_01553|M.leprae_Br4923 DHTTLVDNWDAFATTVATGWALAIH-CGNPECEEDIKAETAATPRCVPRQ
:: * * * : * . :. * :* *..... : .
Rv2845c|M.tuberculosis_H37Rv GMPWIVVVGRGWADGVVELRDRFSGQTRELVAGAS---LATDIAAAVTG-
Mb2870c|M.bovis_AF2122/97 GMPWIVVVGRGWADGVVELRDRFSGQTRELVAGAS---LATDIAAAVTG-
MMAR_1888|M.marinum_M GMPWVVVVGRGWADGVVELRDRFGGQTRELTVGDS---LATDIAAAISG-
MUL_2116|M.ulcerans_Agy99 GMPWVVVVGRGWADGVVELRDRFGGQTRELTVGDS---LATDIAAAISG-
MAV_3700|M.avium_104 GVPWIVVVGRGWADGVVELRDRFAGQTRELATGPS---LAADIAAALRG-
MAB_3140c|M.abscessus_ATCC_199 GVPWIVVIGRGWADGTIELRNRFTGETQPIAVTD----AVASVTQAIG--
MSMEG_2621|M.smegmatis_MC2_155 GMPWIVVVGRGWADGVVELRNRFTGETREIAADG----AAAEISSVLAG-
TH_1980|M.thermoresistible__bu GMPWIVVVGRGWANGVVEVRNRFTGETREVAVADRSGDAAAEIGDLVRA-
Mflv_4045|M.gilvum_PYR-GCK GVPWIVVVGRGWADGVVELRDRFSGEKREIPVGPDT-TAAEQILAAITG-
Mvan_2308|M.vanbaalenii_PYR-1 GVPWIVVVGRGWADGIVELRDRFGGDKHEIPVDG----AAERISAALAGA
MLBr_01553|M.leprae_Br4923 GAPATGRCIRCDAPSAYDKRVIFARAY-----------------------
* * * * . : * *