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M. vanbaalenii PYR-1 Mvan_2308 (-)

annotation: prolyl-tRNA synthetase
coordinates: 2465638 - 2467395
length: 585

VITRMSELFLRTLRDDPADAEVPSHKLLIRAGYVRPVGPGLYSWLPLGLKVLRKIENIVRNEMNAIGGQE
ILFPALLPRAPYETTNRWTEYGDTLFRLQDRRNNDYLLGPTHEEMFTLTVKGEYSSYKDFPLRLYQIQNK
YRDEARPRAGILRGREFLMKDSYSFDIDDDGLKNAYIAHREAYQRIFDLLKVRYVIVSAVSGAMGGSASE
EFLAESDVGEDTYVRCLQSGYAANVEAVVTMVPEPISSEQIAGLASATVHHTGDTPTIATLVDWANGADL
GRTVTAADTLKNVMLKVREPGGEWELLGVGVPGDREVDDKRLGAALEPAEYAMLDDADFARYPFLVKGYI
GPKALLANGVRYLVDPRVVDGTAWITGADELGKHVVDLVAGRDFTPDGTIEAAEVREGDPSPDGAGPLVA
ARGIEIGHVFQLGRKYADAFGADVLGENGKPVRLTMGSYGIGVSRLVAVIAEQHHDELGLRWPSTVSPFD
VHVVIANKDADARTGATELAAELDRLGVDVLLDDRTASPGVKFKDAELLGVPWIVVVGRGWADGIVELRD
RFGGDKHEIPVDGAAERISAALAGA
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_2308--100% (585)prolyl-tRNA synthetase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2870cproS0.082.76% (586) prolyl-tRNA synthetase
M. gilvum PYR-GCKMflv_4045-0.088.83% (591) prolyl-tRNA synthetase
M. tuberculosis H37RvRv2845cproS0.082.94% (586) prolyl-tRNA synthetase
M. leprae Br4923MLBr_01553proS1e-0729.05% (148) prolyl-tRNA synthetase
M. abscessus ATCC 19977MAB_3140c-0.082.30% (582) prolyl-tRNA synthetase
M. marinum MMMAR_1888proS0.081.54% (585) prolyl-tRNA synthetase ProS
M. avium 104MAV_3700proS0.083.93% (585) prolyl-tRNA synthetase
M. smegmatis MC2 155MSMEG_2621proS0.082.82% (588) prolyl-tRNA synthetase
M. thermoresistible (build 8)TH_1980proS0.082.91% (585) PROBABLE PROLYL-TRNA SYNTHETASE PROS (PROLINE--TRNA LIGASE)
M. ulcerans Agy99MUL_2116proS0.081.37% (585) prolyl-tRNA synthetase

CLUSTAL 2.0.9 multiple sequence alignment


Mb2870c|M.bovis_AF2122/97           MITRMSELFLRTLRDDPADAEVASHKLLIRAGYIR-PVAPGLYSWLPLGL
Rv2845c|M.tuberculosis_H37Rv        MITRMSELFLRTLRDDPADAEVASHKLLIRAGYIR-PVAPGLYSWLPLGL
MMAR_1888|M.marinum_M               MITRMSELFLRTLRDDPADAEVPSHKLLIRAGYIR-PVGPGLYSWLPLGL
MUL_2116|M.ulcerans_Agy99           MITRMSELFLRTLRDDPADAEVPSHKLLIRAGYIR-PVGPGLYSWLPLGL
MAV_3700|M.avium_104                MITRMSQLFLRTLRDDPADAEVPSHKLLIRAGYIR-PVAPGLYSWLPLGL
Mvan_2308|M.vanbaalenii_PYR-1       MITRMSELFLRTLRDDPADAEVPSHKLLIRAGYVR-PVGPGLYSWLPLGL
Mflv_4045|M.gilvum_PYR-GCK          MITRMSELFLRTLRDDPADAEVPSHKLLIRAGYVR-PVGPGLYSWLPLGL
MAB_3140c|M.abscessus_ATCC_199      MITRLSELFVRTLRDDPADAEVPSHKLLIRAGYVR-PVAPGVYSWLPLGL
MSMEG_2621|M.smegmatis_MC2_155      MITRMSELFLRTLRDDPADAEVPSHKLLIRAGYVR-AVGPGIYSWLPLGL
TH_1980|M.thermoresistible__bu      VITRMSELFLRTLRDDPADAEVPSHKLLIRAGYIR-PVGPGLYSWLPLGL
MLBr_01553|M.leprae_Br4923          -----MGCNKRGVTRQEDDFSAWYNEVVAKAGLIDRGPAKGTMVIRPYGY
                                              * :  :  * ..  :::: :** :    . *     * * 

Mb2870c|M.bovis_AF2122/97           RVLRNIERVIRDEMNAIGGQEILFPALLPRAPYETTNRWTQYGDSVFRLK
Rv2845c|M.tuberculosis_H37Rv        RVLRNIERVIRDEMNAIGGQEILFPALLPRAPYETTNRWTQYGDSVFRLK
MMAR_1888|M.marinum_M               RVLRNIERVIREEMNAIGGQEILFPALLPRAPYETTNRWTEYGDGVFRLQ
MUL_2116|M.ulcerans_Agy99           RVLRNIERVIREEMNAIGGQEILFPALLPRAPYETTNRWTEYGDGVFRLE
MAV_3700|M.avium_104                RVLRRIEHIVREEMNAIGGQEILFPALLPRAPYEATNRWTEYGDSVFRLQ
Mvan_2308|M.vanbaalenii_PYR-1       KVLRKIENIVRNEMNAIGGQEILFPALLPRAPYETTNRWTEYGDTLFRLQ
Mflv_4045|M.gilvum_PYR-GCK          KVLRKIEHIVRSEMDAIGGQEILFPALLPRAPYETTNRWTEYGDTLFRLQ
MAB_3140c|M.abscessus_ATCC_199      RVLRKIENIVREEMNAIGGQEILLPALLPRAPYETTNRWTEYGDSLFRLK
MSMEG_2621|M.smegmatis_MC2_155      RVLRKIENVVRSEMNAIGAQEILLPALLPRGPYETTNRWTEYGDTLFRLQ
TH_1980|M.thermoresistible__bu      RVLRNIEEIVRQEMVAIGGQEILFPALLPRGPYETTNRWSEYGDTLFRLK
MLBr_01553|M.leprae_Br4923          RIWELLQDELDSKIKELGHENAYFPMLIPENYFNREAEHVEGFHPELAVV
                                    :: . ::  : .::  :* ::  :* *:*.  ::   .  :  .  : : 

Mb2870c|M.bovis_AF2122/97           DRRGND-----YLLGPTHEELFTLTVKGEYSSYKDFPLTLYQIQTKYRDE
Rv2845c|M.tuberculosis_H37Rv        DRRGND-----YLLGPTHEELFTLTVKGEYSSYKDFPLTLYQIQTKYRDE
MMAR_1888|M.marinum_M               DRRGND-----YLLGPTHEELFTLTVKGEYNSYKDFPLTLYQIQIKYRDE
MUL_2116|M.ulcerans_Agy99           DRRGND-----YLLGPTHEELFTLTVKGEYNSYKDFPLTLYQIQIKYRDE
MAV_3700|M.avium_104                DRRGND-----YLLGPTHEELFTLTVKGEYSSYKDFPVLLYQIQNKYRDE
Mvan_2308|M.vanbaalenii_PYR-1       DRRNND-----YLLGPTHEEMFTLTVKGEYSSYKDFPLRLYQIQNKYRDE
Mflv_4045|M.gilvum_PYR-GCK          DRRDND-----YLLGPTHEEMFTLTVKGEYSSYKDFPLRLYQIQNKYRDE
MAB_3140c|M.abscessus_ATCC_199      DRRDND-----MMLGPTHEELFALTVKGEYSSYKDFPVILYQVQTKYRDE
MSMEG_2621|M.smegmatis_MC2_155      DRRNND-----YLLGPTHEELFTLTVKGEYSSYKDFPVILYQIQTKYRDE
TH_1980|M.thermoresistible__bu      DRRDND-----YLLGPTHEELFTLTVKGEYSSYKDFPLLLFQIQTKYRDE
MLBr_01553|M.leprae_Br4923          THAGGKELSEPLVIRPTSETVIGDMMAKWITSHRDLPLRLNQWSNVVRWE
                                     : ...      :: ** * ::   :    .*::*:*: * * .   * *

Mb2870c|M.bovis_AF2122/97           ARPRAGILRAREFVMKDSYSFDIDAAGLKAAYRAHREAYQRIFDRLQVRY
Rv2845c|M.tuberculosis_H37Rv        ARPRAGILRAREFVMKDSYSFDIDAAGLKAAYHAHREAYQRIFDRLQVRY
MMAR_1888|M.marinum_M               ARPRAGILRAREFVMKDSYSFDIDSGGLKAAYHAHREAYQRIFDRLRVRY
MUL_2116|M.ulcerans_Agy99           ARPRAGILRAREFVMKDSYSFDIDSGGLKAAYHAHREAYQRIFDRLRVRY
MAV_3700|M.avium_104                ARPRAGILRVREFVMKDSYSFDIDDAGLKAAYHAHREAYQRIFARLQVRY
Mvan_2308|M.vanbaalenii_PYR-1       ARPRAGILRGREFLMKDSYSFDIDDDGLKNAYIAHREAYQRIFDLLKVRY
Mflv_4045|M.gilvum_PYR-GCK          ARPRAGILRGREFLMKDSYSFDVDDDGLKNAYHAHREAYQRIFDRLKVRY
MAB_3140c|M.abscessus_ATCC_199      ARPRAGILRGREFVMKDSYSFDTSDDGLKAAYHAHRDAYQRIFGRLGLDY
MSMEG_2621|M.smegmatis_MC2_155      ARPRAGILRGREFVMKDSYSFDVDDDGLKNAYYQHREAYQRIFARLGVRY
TH_1980|M.thermoresistible__bu      ARPRAGILRGREFVMKDSYSFDVDDAGLKAVYQAHRDAYQRIFDRLGVRY
MLBr_01553|M.leprae_Br4923          LRPRM-LLRTIEFLWQEGHSAHIE----KSDALRETLFALDIYTTLARDM
                                     ***  :**  **: ::.:* . .    *     .      *:  *    

Mb2870c|M.bovis_AF2122/97           VIVSAVSGAMGGSASEEFLAESPSGEDAFVRCLESGYTANVEAVVTARPD
Rv2845c|M.tuberculosis_H37Rv        VIVSAVSGAMGGSASEEFLAESPSGEDAFVRCLESGYAANVEAVVTARPD
MMAR_1888|M.marinum_M               VIVSAVSGAMGGSASEEFLAESPVGEDTFVRCVESGYAANVEAVVTARPE
MUL_2116|M.ulcerans_Agy99           VIVSAVSGAMGGSASEEFLAESPVGEDTFVRCVESGYAANVEAVVTARPE
MAV_3700|M.avium_104                VIVSAVSGAMGGSASEEFLAESPVGEDTFVRCLESGYAANVEAVITARPD
Mvan_2308|M.vanbaalenii_PYR-1       VIVSAVSGAMGGSASEEFLAESDVGEDTYVRCLQSGYAANVEAVVTMVPE
Mflv_4045|M.gilvum_PYR-GCK          VIVSAVSGAMGGSASEEFLAESEVGEDTFVRCAQSGYAANVEAVVTTAPD
MAB_3140c|M.abscessus_ATCC_199      VIVAATSGAMGGSASEEFLAESPTGEDTFVRCVESGYAANVEAVITPAPP
MSMEG_2621|M.smegmatis_MC2_155      VIVSAVSGAMGGSASEEFLAESEVGEDTFVRCVESGYAANVEAVITRAPE
TH_1980|M.thermoresistible__bu      VIVSAVSGAMGGSASEEFLAESEVGEDTFVRCPESGYAANVEAVVTPAPE
MLBr_01553|M.leprae_Br4923          AAIPIVSGEK--TAGERFAGALN--------------TYTIEAMMRDG--
                                    . :. .**    :*.*.* .                 : .:**::     

Mb2870c|M.bovis_AF2122/97           TLP---IDGLPEAVVHDTGDTPTIASLVAWANEADL----GRTVTAADTL
Rv2845c|M.tuberculosis_H37Rv        TLP---IDGLPEAVVHDTGDTPTIASLVAWANEADL----GRTVTAADTL
MMAR_1888|M.marinum_M               SLP---IDGQPDAVVHDTGETPTIATLVAWANEAGL----GREVSAADTL
MUL_2116|M.ulcerans_Agy99           SLP---IDGQPDAVVHDTGETPTIATLVAWANEAGL----GREVSAADTL
MAV_3700|M.avium_104                PQP---VEGLPEAVVHDTGDTPTIATLVDWANRAGL----GRTVTAADTL
Mvan_2308|M.vanbaalenii_PYR-1       PISSEQIAGLASATVHHTGDTPTIATLVDWANGADL----GRTVTAADTL
Mflv_4045|M.gilvum_PYR-GCK          PIP---LDGLPEAVVYDTPDTPTIATLVDWANTADLPSFAGRAVTAADTL
MAB_3140c|M.abscessus_ATCC_199      ARP---IEGLAEAVVHETGDTPTIATLVDWANSAGL----GRTVTAADTL
MSMEG_2621|M.smegmatis_MC2_155      AQP---TEGLPEAKVYDTPDTPTIATLVEWANSASLPQFEGRTVTAADTL
TH_1980|M.thermoresistible__bu      PRP---IDGLPEPKVYDTPDTATIATLVDWANRADLPGFEGREVTAADTL
MLBr_01553|M.leprae_Br4923          -------KALQSATTHYLGDNFARAFNIRYTTAEEQ--------------
                                            .  .. .:   :. : *  : ::.                  

Mb2870c|M.bovis_AF2122/97           KNVLIKVRQPGGDTELLAIGVPGDREVDDKRLGAALEPADYALLDDDDFA
Rv2845c|M.tuberculosis_H37Rv        KNVLIKVRQPGGDTELLAIGVPGDREVDDKRLGAALEPADYALLDDDDFA
MMAR_1888|M.marinum_M               KNVLMKIRQPGGEWELLAIGVPGDREIDEKRLAAALDPAEYVFLDDDDFG
MUL_2116|M.ulcerans_Agy99           KNVLMKIRQPGGEWELLAIGVPGDREIDEKRLAAALDPAEYVFLDDDDFG
MAV_3700|M.avium_104                KNVLLKVRQPGGDWELLAIGLPGDREVDDKRLGAALEPAEYVLLDDADFA
Mvan_2308|M.vanbaalenii_PYR-1       KNVMLKVREPGGEWELLGVGVPGDREVDDKRLGAALEPAEYAMLDDADFA
Mflv_4045|M.gilvum_PYR-GCK          KNVLLKVREPGGDWELLAIGVPGDREVDDKRLGAALDPAEYAMADDADFA
MAB_3140c|M.abscessus_ATCC_199      KNILLKVRQPGGDWELLAVGVPGDREVDDKRLGAALEPAEYELLGDADFA
MSMEG_2621|M.smegmatis_MC2_155      KNVLLKTREPGGEWELLAVGVPGDREVDEKRLGAALEPAEFALLDDADFA
TH_1980|M.thermoresistible__bu      KNVVLKVREPGGDWELLAIGLPGDREVDDKRLGAALDPAEYEFLDDADFA
MLBr_01553|M.leprae_Br4923          -QAFVHTTSFGLSTRMIGAIVMVHGDDKGLVLPPQVAPYQVVIVPITTGN
                                     : .::  . * . .::.  :  . : .   * . : * :  :       

Mb2870c|M.bovis_AF2122/97           KHPFLVKGYIG-PKALRENNVRYLVDPRIVDGTSWITGADQPGRHVVGLV
Rv2845c|M.tuberculosis_H37Rv        KHPFLVKGYIG-PKALRENNVRYLVDPRIVDGTSWITGADQPGRHVVGLV
MMAR_1888|M.marinum_M               KYPFLVKGYIG-PKALRSNDVRYLLDPRVVDGTSWITGADEPGRHVVGLV
MUL_2116|M.ulcerans_Agy99           KYPFLVKGYIG-PKALRSNDVRYLLDPRVVDGTSWITGADEPGRHVVGLV
MAV_3700|M.avium_104                RYPFLVKGYIG-PKALKDNGVRYLVDPRVVDGTSWITGADEPGRHVVGLV
Mvan_2308|M.vanbaalenii_PYR-1       RYPFLVKGYIG-PKALLANGVRYLVDPRVVDGTAWITGADELGKHVVDLV
Mflv_4045|M.gilvum_PYR-GCK          AHPFLKKGYIG-PKALLANGVRYLVDPRVVDGTAWITGADETGRHVVDLV
MAB_3140c|M.abscessus_ATCC_199      KYPFLVRGYIG-PKALLANGVRYLVDPRVVEGTSWITGADEPGKHVVDLV
MSMEG_2621|M.smegmatis_MC2_155      ANPFLVKGYVG-PKALQDNGVRYLVDPRVVHGSSWITGADAPNRHVVGLV
TH_1980|M.thermoresistible__bu      RHPFLAKGYIG-PKALQANGVRYLVDPRVVTGTSWITGADEPGRHVVGLV
MLBr_01553|M.leprae_Br4923          KASEVGHAAADLARRLQAAGVRTHVDARPQLTPGWKYNEWELRGVPIRLE
                                      . : :.  . .: *   .**  :*.*    ..*  .        : * 

Mb2870c|M.bovis_AF2122/97           AGRDFTADGTIEAAEVREGDPSPDGAGPLVMARGIEIGHIFQLGSKYTDA
Rv2845c|M.tuberculosis_H37Rv        AGRDFTADGTIEAAEVREGDPSPDGAGPLVMARGIEIGHIFQLGSKYTDA
MMAR_1888|M.marinum_M               AGRDFTADGTIEAAEVREGDPAPDGAGQLVMARGIEIGHIFQLGRKYTDA
MUL_2116|M.ulcerans_Agy99           AGRDFTADGTIEAAEVREGDPAPDGAGQLVMARGIEIGHIFQLGRKYTDA
MAV_3700|M.avium_104                AGRDFTADGTIEAAEVRDGDPSPDGAGPLVSARGIEVAHIFQLGRKYTDA
Mvan_2308|M.vanbaalenii_PYR-1       AGRDFTPDGTIEAAEVREGDPSPDGAGPLVAARGIEIGHVFQLGRKYADA
Mflv_4045|M.gilvum_PYR-GCK          AGRDFTPDGTIEAAEVREGDPSPDGAGPLVAARGIEIGHVFQLGRKYADA
MAB_3140c|M.abscessus_ATCC_199      AGRDFTADGTIEAAEVRDGDPSPDGAGQLVSARGIEIGHIFQLGRKYTDA
MSMEG_2621|M.smegmatis_MC2_155      AGRDFTPDGTIEAAEVRDGDPSPDGAGVLTSARGIEIGHIFQLGRKYTDA
TH_1980|M.thermoresistible__bu      AGRDFTPDGTIEAAEVRDGDPSPDGAGTLVSARGIEIGHIFQLGRKYTDA
MLBr_01553|M.leprae_Br4923          LG------------------PRDLEAGTTVMVR--------RIGEKAKQP
                                     *                  *    **  . .*        ::* *  :.

Mb2870c|M.bovis_AF2122/97           FTADVLGEDGKPVRLTMGSYGIGVSRLVAVVAEQHHDELGLRWPSTVAPF
Rv2845c|M.tuberculosis_H37Rv        FTADVLGEDGKPVRLTMGSYGIGVSRLVAVVAEQHHDELGLRWPSTVAPF
MMAR_1888|M.marinum_M               FTADVLGEDGKPVRLTMGSYGIGVSRLVAVIAEQHHDNLGLRWPAEIAPF
MUL_2116|M.ulcerans_Agy99           FTADVLGEDGKPVRLTMGSYGIGVSRLVAVIAEQHHDNLGLRWPAEIAPF
MAV_3700|M.avium_104                FTADVLGEDGKPVRLTMGSYGLGVSRMVAVIAEQHHDELGLRWPASVAPF
Mvan_2308|M.vanbaalenii_PYR-1       FGADVLGENGKPVRLTMGSYGIGVSRLVAVIAEQHHDELGLRWPSTVSPF
Mflv_4045|M.gilvum_PYR-GCK          FNADVLGENGKPVRLTMGSYGIGVSRLVAVIAEQHHDELGLRWPGSVAPF
MAB_3140c|M.abscessus_ATCC_199      FTVDVLGENGKPVRLTQGSYGIGVSRLVAVVAEQQHDELGLRWPSAVSPF
MSMEG_2621|M.smegmatis_MC2_155      FSADVLGEDGKPLRLTMGSYGIGVSRLVAVIAEQQHDQLGLRWPSSVAPF
TH_1980|M.thermoresistible__bu      FNVDVLGEDGKPVRLTMGSYGIGVSRLVAVIAEQHHDELGLRWPSSVAPF
MLBr_01553|M.leprae_Br4923          IAIAAAP-----------------TELPGILEEFQRTLLER---ATQFRD
                                    :   .                   :.: .:: * ::  *     .     

Mb2870c|M.bovis_AF2122/97           DVHLVIANKDAQARAGATALAADLDRLGVEVLLDDRQASPGVKFKDAELL
Rv2845c|M.tuberculosis_H37Rv        DVHLVIANKDAQARAGATALAADLDRLGVEVLLDDRQASPGVKFKDAELL
MMAR_1888|M.marinum_M               GVHLVIANKDAEARAGAIGLASELDGLGVEVLLDDRQASPGVKFKDAELL
MUL_2116|M.ulcerans_Agy99           GVHLVIANKDAEARAGAIGLAGELDGLGVEVLLDDRQASPGVKFKDAELL
MAV_3700|M.avium_104                DVHLVIANKDAQARAGATALADDLDRLGVEVLLDDRQASPGVKFKDAELL
Mvan_2308|M.vanbaalenii_PYR-1       DVHVVIANKDADARTGATELAAELDRLGVDVLLDDRTASPGVKFKDAELL
Mflv_4045|M.gilvum_PYR-GCK          AVHVVIANKDAEARAGATELATALDRAGADVLLDDRTASPGVKFKDAELL
MAB_3140c|M.abscessus_ATCC_199      DVHVVIANKDDAARAGAEELAAELDRLGHEVLLDDRTASPGVKFKDAELL
MSMEG_2621|M.smegmatis_MC2_155      DVHVVVANKDAGARAGAAELVADLDRLGHEVLFDDRQASPGVKFKDAELL
TH_1980|M.thermoresistible__bu      DVHVVIANKDSAARAGAEQLAADLDRLGLQVLLDDRTASPGVKFKDAELL
MLBr_01553|M.leprae_Br4923          DHTTLVDNWDAFATTVATGWALAIH-CGNPECEEDIKAETAATPRCVPRQ
                                        :: * *  * : *   .  :.  *     :*  *..... : .   

Mb2870c|M.bovis_AF2122/97           GMPWIVVVGRGWADGVVELRDRFSGQTRELVAGAS---LATDIAAAVTG-
Rv2845c|M.tuberculosis_H37Rv        GMPWIVVVGRGWADGVVELRDRFSGQTRELVAGAS---LATDIAAAVTG-
MMAR_1888|M.marinum_M               GMPWVVVVGRGWADGVVELRDRFGGQTRELTVGDS---LATDIAAAISG-
MUL_2116|M.ulcerans_Agy99           GMPWVVVVGRGWADGVVELRDRFGGQTRELTVGDS---LATDIAAAISG-
MAV_3700|M.avium_104                GVPWIVVVGRGWADGVVELRDRFAGQTRELATGPS---LAADIAAALRG-
Mvan_2308|M.vanbaalenii_PYR-1       GVPWIVVVGRGWADGIVELRDRFGGDKHEIPVDG----AAERISAALAGA
Mflv_4045|M.gilvum_PYR-GCK          GVPWIVVVGRGWADGVVELRDRFSGEKREIPVGPDT-TAAEQILAAITG-
MAB_3140c|M.abscessus_ATCC_199      GVPWIVVIGRGWADGTIELRNRFTGETQPIAVTD----AVASVTQAIG--
MSMEG_2621|M.smegmatis_MC2_155      GMPWIVVVGRGWADGVVELRNRFTGETREIAADG----AAAEISSVLAG-
TH_1980|M.thermoresistible__bu      GMPWIVVVGRGWANGVVEVRNRFTGETREVAVADRSGDAAAEIGDLVRA-
MLBr_01553|M.leprae_Br4923          GAPATGRCIRCDAPSAYDKRVIFARAY-----------------------
                                    * *      *  * .  : *  *