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TEFSSFSAPKGVPDYVPPDSAQFVAVRDGLLAAARQAGYSHIELPIFEDTALFARGVGESTDVVSKEMYT FADRGDRSVTLRPEGTAGVVRAVIEHGLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDP ALDAEVIAIADAGFRSLGLDGFRLEITSLGDESCRPQYRELLQEFLFGLDLDEDTRRRAGINPLRVLDDK RPELRAMTASAPVLLDHLSDVAKQHFDTVLAHLDALGVPYVINPRMVRGLDYYTKTAFEFVHDGLGAQSG IGGGGRYDGLMHQLGGQDLSGIGFGLGVDRTVLALRAEGKTAGDSARCDVFGVPLGEAAKLRLAVLAGRL RAAGVRVDLAYGDRGLKGAMRAAARSGARVALVAGDRDIEAGTVAVKDLTTGEQVSVSMDSVVAEVISRL AG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2580c | hisS | - | 100% (423) | histidyl-tRNA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2611c | hisS | 0.0 | 100.00% (423) | histidyl-tRNA synthetase |
| M. gilvum PYR-GCK | Mflv_3809 | hisS | 0.0 | 85.34% (416) | histidyl-tRNA synthetase |
| M. leprae Br4923 | MLBr_00494 | hisS | 0.0 | 85.85% (417) | histidyl-tRNA synthetase |
| M. abscessus ATCC 19977 | MAB_2872c | hisS | 0.0 | 80.34% (417) | histidyl-tRNA synthetase |
| M. marinum M | MMAR_2127 | hisS | 0.0 | 92.33% (417) | histidyl-tRNA synthetase HisS |
| M. avium 104 | MAV_3460 | hisS | 0.0 | 90.14% (416) | histidyl-tRNA synthetase |
| M. smegmatis MC2 155 | MSMEG_2976 | hisS | 0.0 | 83.96% (424) | histidyl-tRNA synthetase |
| M. thermoresistible (build 8) | TH_2331 | hisS | 0.0 | 85.57% (409) | PROBABLE HISTIDYL-TRNA SYNTHETASE HISS (HISTIDINE--TRNA |
| M. ulcerans Agy99 | MUL_1732 | hisS | 0.0 | 92.09% (417) | histidyl-tRNA synthetase |
| M. vanbaalenii PYR-1 | Mvan_2590 | hisS | 0.0 | 86.02% (422) | histidyl-tRNA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2580c|M.tuberculosis_H37Rv MTEFSSFS---APKGVPDYVPPDSAQFVAVRDGLLAAARQAGYSHIELPI
Mb2611c|M.bovis_AF2122/97 MTEFSSFS---APKGVPDYVPPDSAQFVAVRDGLLAAARQAGYSHIELPI
MMAR_2127|M.marinum_M MTEFC------APKGVPDYVPPDSAQFVAVRDGLLTAARRAGYGHIELPI
MUL_1732|M.ulcerans_Agy99 MTEFC------APKGVPDYVPPDSAQFVAVRDGLLTAARRAGYGHIELPI
MLBr_00494|M.leprae_Br4923 MTESCTVFSFSGPKGIPDYFPPDSAQFVAVRDGLLTAARRAGYGDIELPV
MAV_3460|M.avium_104 MPEFS------APKGVPDYVPPDSAQFVAVRSGLLDAARGAGYGDIELPI
MSMEG_2976|M.smegmatis_MC2_155 MTEGSSPVAFQAPKGVPDYLPPDSAQFVAVRDGLLSAARRAGYGDIELPI
TH_2331|M.thermoresistible__bu ---------------VPDYLPPESAQFVAVRDGLLRAAHRAGYGHIELPI
Mflv_3809|M.gilvum_PYR-GCK MTD-----SFKAPKGVPDYFPPDSAEFVAVRSGLLTAARRAGYGDIELPI
Mvan_2590|M.vanbaalenii_PYR-1 MTELS---SFKAPKGVPDYLPPASAEFVAVRNGLLAAARRAGYGDIELPI
MAB_2872c|M.abscessus_ATCC_199 MSEKT----FSAPKGIPDYVPPDSAQFLAVRDGLLEQARLAGYGYIELPV
:***.** **:*:***.*** *: ***. ****:
Rv2580c|M.tuberculosis_H37Rv FEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEH
Mb2611c|M.bovis_AF2122/97 FEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEH
MMAR_2127|M.marinum_M FEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEH
MUL_1732|M.ulcerans_Agy99 FEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEH
MLBr_00494|M.leprae_Br4923 FEDTALFARGVGESTDVVAKEMYTFADRGDRSVTLRPEGTAGVVRAVIEH
MAV_3460|M.avium_104 FEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEH
MSMEG_2976|M.smegmatis_MC2_155 FEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVIRAVIQH
TH_2331|M.thermoresistible__bu FEDTALFARGVGESTDVVTKEMYTFADRGDRSVTLRPEGTAGVIRAVIEH
Mflv_3809|M.gilvum_PYR-GCK FEDTALFARGVGESTDVVSKEMYTFADRGERSVTLRPEGTAGVMRAVIEH
Mvan_2590|M.vanbaalenii_PYR-1 FEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVMRAVIEH
MAB_2872c|M.abscessus_ATCC_199 FEDTGLFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTASVMRAVIEH
****.*************:**********:***********.*:****:*
Rv2580c|M.tuberculosis_H37Rv GLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
Mb2611c|M.bovis_AF2122/97 GLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
MMAR_2127|M.marinum_M GLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
MUL_1732|M.ulcerans_Agy99 GLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
MLBr_00494|M.leprae_Br4923 GLDRGALPVKLCYAGPFFRYERPQAGRCRQLQQVGVEAIGVDDPALDAEV
MAV_3460|M.avium_104 GLDRGTLPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
MSMEG_2976|M.smegmatis_MC2_155 RLDRGALPVKLCYSGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
TH_2331|M.thermoresistible__bu GLDRGPLPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
Mflv_3809|M.gilvum_PYR-GCK GLDRGQLPVKLCYSGPFFRYERPQAGRYRQLQQVGIEAIGVDDPALDAEV
Mvan_2590|M.vanbaalenii_PYR-1 GLDRGQLPVKLCYSGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
MAB_2872c|M.abscessus_ATCC_199 GLDRGQLPAKLRYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
**** **.** *:************* *******:**************
Rv2580c|M.tuberculosis_H37Rv IAIADAGFRSLGLDGFRLEITSLGDESCRPQYRELLQEFLFGLDLDEDTR
Mb2611c|M.bovis_AF2122/97 IAIADAGFRSLGLDGFRLEITSLGDESCRPQYRELLQEFLFGLDLDEDTR
MMAR_2127|M.marinum_M IAIADAGFRSLGLDGFRLEVTSLGDETCRPQYRELLQEFLFGLDLDDDTR
MUL_1732|M.ulcerans_Agy99 IAIADAGFRSLGLDGFRLEITSLGDETCRPQYRELLQEFLFGLDLDDETR
MLBr_00494|M.leprae_Br4923 ITIADAGFRSLGLDGFQLEITSLGDGTCRPQYRKLLQEFLLQLDLDEDTR
MAV_3460|M.avium_104 IAVADAGFRSLGLDGFRLEITSLGDDSCRPQYRELLQDFLFGLDLDEETR
MSMEG_2976|M.smegmatis_MC2_155 IAVADAGFRSLGLSGFRLEITSLGDDTCRPAYRELLQEFLFKLDLDEETR
TH_2331|M.thermoresistible__bu IAVADAGFRSLGLTDFRLEITSLGDETCRPQYRELLQEFLFKLDLDEETR
Mflv_3809|M.gilvum_PYR-GCK MAVADAGFRSLGLDGFRLEITSLGDDSCRPQYRELLQEFLFKLDLDEETR
Mvan_2590|M.vanbaalenii_PYR-1 IAVADAGFRSLGLDGFRLDITSLGDDSCRPQYRELLQEFLFKLDLDEETR
MAB_2872c|M.abscessus_ATCC_199 IAIADAGYRSLGLTGFRLEISSLGDASCRPQYRELLQEFLFGLDLDEATR
:::****:***** .*:*:::**** :*** **:***:**: ****: **
Rv2580c|M.tuberculosis_H37Rv RRAGINPLRVLDDKRPELRAMTASAPVLLDHLSDVAKQHFDTVLAHLDAL
Mb2611c|M.bovis_AF2122/97 RRAGINPLRVLDDKRPELRAMTASAPVLLDHLSDVAKQHFDTVLAHLDAL
MMAR_2127|M.marinum_M RRAALNPLRVLDDKRPEVRAMTAEAPVLLDHLSDVAKQHFDTVLAHLDAL
MUL_1732|M.ulcerans_Agy99 RRAALNPLRVLDDKRPEVRAMTAEAPVLLDHLSDVAKQHFDTVLAHLDAL
MLBr_00494|M.leprae_Br4923 RRAELNPLRVLDDKRPQVQAMTAAAPVLLDHLSDGAKQHFDTVLAHLDAL
MAV_3460|M.avium_104 RRARLNPLRVLDDKRPEVRAMTADAPVLLDHLSDAAKQHFDTVLAHLDAL
MSMEG_2976|M.smegmatis_MC2_155 RRAEINPLRVLDDKRPHVREMTADAPLMLDHLSDSAKEHFETVQTYLDAL
TH_2331|M.thermoresistible__bu RRAQINPLRVLDDKRPHVREMTADAPVMLDHLSDSAKQHFDTVLAYLDAL
Mflv_3809|M.gilvum_PYR-GCK QRAQLNPLRVLDDKRPHVREMTANAPVMLDHLSDAAKEHFDTVLAHLDAL
Mvan_2590|M.vanbaalenii_PYR-1 RRAEINPLRVLDDKRPHMKEMTADAPVMLDHLSDAAKQHFDTVLAHLDAL
MAB_2872c|M.abscessus_ATCC_199 ERARINPIRVLDDKRPEVREMTANAPLMLDHLSGEAKAHFEQVLSHLDAL
.** :**:********.:: *** **::*****. ** **: * ::****
Rv2580c|M.tuberculosis_H37Rv GVPYVINPRMVRGLDYYTKTAFEFVHDGLGAQSGIGGGGRYDGLMHQLGG
Mb2611c|M.bovis_AF2122/97 GVPYVINPRMVRGLDYYTKTAFEFVHDGLGAQSGIGGGGRYDGLMHQLGG
MMAR_2127|M.marinum_M RVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMKQLGG
MUL_1732|M.ulcerans_Agy99 RVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMKQLGG
MLBr_00494|M.leprae_Br4923 RVPYVINPRMVRGLDYYTKTTFEFVHPGLGAQSGIGGGGRYDGLMRQLGG
MAV_3460|M.avium_104 GVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMRQLGG
MSMEG_2976|M.smegmatis_MC2_155 GVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMRQLGG
TH_2331|M.thermoresistible__bu EVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMRQLGG
Mflv_3809|M.gilvum_PYR-GCK SVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMAQLGG
Mvan_2590|M.vanbaalenii_PYR-1 SVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMHQLGG
MAB_2872c|M.abscessus_ATCC_199 GVQYVVNPRLVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMAQLGG
* **:***:**********:***** ****************** ****
Rv2580c|M.tuberculosis_H37Rv QDLSGIGFGLGVDRTVLALRAEGKTAGDSARCDVFGVPLGEAAKLRLAVL
Mb2611c|M.bovis_AF2122/97 QDLSGIGFGLGVDRTVLALRAEGKTAGDSARCDVFGVPLGEAAKLRLAVL
MMAR_2127|M.marinum_M QDLSGIGFGLGVDRTMLALRAEGKSVGESARCDVFGVPLSEQAKLTLAVL
MUL_1732|M.ulcerans_Agy99 QDLSGIGFGLGVDRTMLALRAEGKSVGESARCDVFGVPLSEQAKLTLAVL
MLBr_00494|M.leprae_Br4923 QDLSGIGFGLGVDRTLLALHAEGKTVGETTRCDVFGVSLGEAAKLKVAML
MAV_3460|M.avium_104 QDLSGIGFGLGVDRTLLALRAEGKSVGSAARCDVFGVPLSDQAKLRLAVL
MSMEG_2976|M.smegmatis_MC2_155 QDVSGIGFGLGVDRTLLALQAEGVTIEGAGGVEVFGVPLGAAAKLELAKL
TH_2331|M.thermoresistible__bu QDVSGIGFGLGVDRTMLALKAEGKQVGETARVQVFCVPLGAEAKLKLAVL
Mflv_3809|M.gilvum_PYR-GCK RDLSGIGFGLGVDRTLLALRAEGKAAGETARVDVYAVPLGADAKVRLAVL
Mvan_2590|M.vanbaalenii_PYR-1 RDLSGIGFGLGVDRTLLALRAEGKTAGETARVDVYAVPLGGDAKVRLAVL
MAB_2872c|M.abscessus_ATCC_199 QSLSGIGFGLGVDRTVLALRAEGVTVGDSGRCEVFCVPLGQDAKSVLVKV
:.:************:***:*** : :*: *.*. ** :. :
Rv2580c|M.tuberculosis_H37Rv AGRLRAAGVRVDLAYGDRGLKGAMRAAARSGARVALVAGDRDIEAGTVAV
Mb2611c|M.bovis_AF2122/97 AGRLRAAGVRVDLAYGDRGLKGAMRAAARSGARVALVAGDRDIEAGTVAV
MMAR_2127|M.marinum_M AGQLRASGVRVDLAYGDRGLKGAMRAADRSGARVALVAGDRDIEAGTVGV
MUL_1732|M.ulcerans_Agy99 AGQLRASGVRVDLAYGDRGLKGAMRAADRSGARVALVTGDRDIEAGTVGV
MLBr_00494|M.leprae_Br4923 AGQLRAAGVRVDLIYGDRGIRGAMRAAGRSGARIALIVDDCAIKADGVGV
MAV_3460|M.avium_104 AAGLRAAGVRVDMAYGARGLKGAMRAADRSGARIALVLGDRDIDAGTVGV
MSMEG_2976|M.smegmatis_MC2_155 AAKLRAGGARVDLAYGDRGLKGAMKAADRSGAKYALVAGDRDIEAGTVGL
TH_2331|M.thermoresistible__bu AAKLRAAGIRVDMAYGDRGLKGAMRAADRSGAAVAVVAGDRDIEAGTFGV
Mflv_3809|M.gilvum_PYR-GCK AAQLRAAGVRVDVAYGDRSLKGAMKGADRSGASIALVAGDRDLEAGTVGV
Mvan_2590|M.vanbaalenii_PYR-1 AAQLRAAGVRVDVAYGDRSLKGAMKGADRSGASIALVAGDRDLEAGTVGM
MAB_2872c|M.abscessus_ATCC_199 AAQLRGAGIRTDIAYGDRGLKGAMRGADRSGASIALVAGDREIGEGNIEL
*. **..* *.*: ** *.::***:.* **** *:: .* : . . :
Rv2580c|M.tuberculosis_H37Rv KDLTTGEQVSVSMDSVVAEVISRLAG--
Mb2611c|M.bovis_AF2122/97 KDLTTGEQVSVSMDSVVAEVISRLAG--
MMAR_2127|M.marinum_M KDLGTGEQVSVSTDSVVDDVISKLGR--
MUL_1732|M.ulcerans_Agy99 KDLGTGEQVSVSTDSVVDDVISKLGR--
MLBr_00494|M.leprae_Br4923 RDLATGEQISVAVDSVVAEVISRIAPS-
MAV_3460|M.avium_104 KDLQTGSQVSVELDSVVAEVLSQLSR--
MSMEG_2976|M.smegmatis_MC2_155 KDLSTGDQIDVPADSVVAEVLSRLGR--
TH_2331|M.thermoresistible__bu KDLASGEQVDVPMDAVLDDILARLN---
Mflv_3809|M.gilvum_PYR-GCK KSMATGEQVDVASDDVVAEVLSRLT---
Mvan_2590|M.vanbaalenii_PYR-1 KSMATGEQVDVAVEGVVAEVLSRLS---
MAB_2872c|M.abscessus_ATCC_199 KTLADGVQQPVPIGSIVGEVTARLASRI
: : * * * :: :: :::