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VTELSSFKAPKGVPDYLPPASAEFVAVRNGLLAAARRAGYGDIELPIFEDTALFARGVGESTDVVSKEMY TFADRGDRSVTLRPEGTAGVMRAVIEHGLDRGQLPVKLCYSGPFFRYERPQAGRYRQLQQVGVEAIGVDD PALDAEVIAVADAGFRSLGLDGFRLDITSLGDDSCRPQYRELLQEFLFKLDLDEETRRRAEINPLRVLDD KRPHMKEMTADAPVMLDHLSDAAKQHFDTVLAHLDALSVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQS GIGGGGRYDGLMHQLGGRDLSGIGFGLGVDRTLLALRAEGKTAGETARVDVYAVPLGGDAKVRLAVLAAQ LRAAGVRVDVAYGDRSLKGAMKGADRSGASIALVAGDRDLEAGTVGMKSMATGEQVDVAVEGVVAEVLSR LS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2590 | hisS | - | 100% (422) | histidyl-tRNA synthetase |
| M. vanbaalenii PYR-1 | Mvan_2558 | thrS | 7e-05 | 32.65% (98) | threonyl-tRNA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2611c | hisS | 0.0 | 86.02% (422) | histidyl-tRNA synthetase |
| M. gilvum PYR-GCK | Mflv_3809 | hisS | 0.0 | 94.48% (417) | histidyl-tRNA synthetase |
| M. tuberculosis H37Rv | Rv2580c | hisS | 0.0 | 86.02% (422) | histidyl-tRNA synthetase |
| M. leprae Br4923 | MLBr_00494 | hisS | 0.0 | 81.06% (417) | histidyl-tRNA synthetase |
| M. abscessus ATCC 19977 | MAB_2872c | hisS | 0.0 | 77.94% (417) | histidyl-tRNA synthetase |
| M. marinum M | MMAR_2127 | hisS | 0.0 | 83.97% (418) | histidyl-tRNA synthetase HisS |
| M. avium 104 | MAV_3460 | hisS | 0.0 | 86.78% (416) | histidyl-tRNA synthetase |
| M. smegmatis MC2 155 | MSMEG_2976 | hisS | 0.0 | 84.67% (424) | histidyl-tRNA synthetase |
| M. thermoresistible (build 8) | TH_2331 | hisS | 0.0 | 85.37% (410) | PROBABLE HISTIDYL-TRNA SYNTHETASE HISS (HISTIDINE--TRNA |
| M. ulcerans Agy99 | MUL_1732 | hisS | 0.0 | 84.21% (418) | histidyl-tRNA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2611c|M.bovis_AF2122/97 MTEFSSFS---APKGVPDYVPPDSAQFVAVRDGLLAAARQAGYSHIELPI
Rv2580c|M.tuberculosis_H37Rv MTEFSSFS---APKGVPDYVPPDSAQFVAVRDGLLAAARQAGYSHIELPI
MMAR_2127|M.marinum_M MTEFC------APKGVPDYVPPDSAQFVAVRDGLLTAARRAGYGHIELPI
MUL_1732|M.ulcerans_Agy99 MTEFC------APKGVPDYVPPDSAQFVAVRDGLLTAARRAGYGHIELPI
MLBr_00494|M.leprae_Br4923 MTESCTVFSFSGPKGIPDYFPPDSAQFVAVRDGLLTAARRAGYGDIELPV
MAV_3460|M.avium_104 MPEFS------APKGVPDYVPPDSAQFVAVRSGLLDAARGAGYGDIELPI
Mvan_2590|M.vanbaalenii_PYR-1 MTELS---SFKAPKGVPDYLPPASAEFVAVRNGLLAAARRAGYGDIELPI
Mflv_3809|M.gilvum_PYR-GCK MTD-----SFKAPKGVPDYFPPDSAEFVAVRSGLLTAARRAGYGDIELPI
MSMEG_2976|M.smegmatis_MC2_155 MTEGSSPVAFQAPKGVPDYLPPDSAQFVAVRDGLLSAARRAGYGDIELPI
TH_2331|M.thermoresistible__bu ---------------VPDYLPPESAQFVAVRDGLLRAAHRAGYGHIELPI
MAB_2872c|M.abscessus_ATCC_199 MSEKT----FSAPKGIPDYVPPDSAQFLAVRDGLLEQARLAGYGYIELPV
:***.** **:*:***.*** *: ***. ****:
Mb2611c|M.bovis_AF2122/97 FEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEH
Rv2580c|M.tuberculosis_H37Rv FEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEH
MMAR_2127|M.marinum_M FEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEH
MUL_1732|M.ulcerans_Agy99 FEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEH
MLBr_00494|M.leprae_Br4923 FEDTALFARGVGESTDVVAKEMYTFADRGDRSVTLRPEGTAGVVRAVIEH
MAV_3460|M.avium_104 FEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEH
Mvan_2590|M.vanbaalenii_PYR-1 FEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVMRAVIEH
Mflv_3809|M.gilvum_PYR-GCK FEDTALFARGVGESTDVVSKEMYTFADRGERSVTLRPEGTAGVMRAVIEH
MSMEG_2976|M.smegmatis_MC2_155 FEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVIRAVIQH
TH_2331|M.thermoresistible__bu FEDTALFARGVGESTDVVTKEMYTFADRGDRSVTLRPEGTAGVIRAVIEH
MAB_2872c|M.abscessus_ATCC_199 FEDTGLFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTASVMRAVIEH
****.*************:**********:***********.*:****:*
Mb2611c|M.bovis_AF2122/97 GLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
Rv2580c|M.tuberculosis_H37Rv GLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
MMAR_2127|M.marinum_M GLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
MUL_1732|M.ulcerans_Agy99 GLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
MLBr_00494|M.leprae_Br4923 GLDRGALPVKLCYAGPFFRYERPQAGRCRQLQQVGVEAIGVDDPALDAEV
MAV_3460|M.avium_104 GLDRGTLPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
Mvan_2590|M.vanbaalenii_PYR-1 GLDRGQLPVKLCYSGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
Mflv_3809|M.gilvum_PYR-GCK GLDRGQLPVKLCYSGPFFRYERPQAGRYRQLQQVGIEAIGVDDPALDAEV
MSMEG_2976|M.smegmatis_MC2_155 RLDRGALPVKLCYSGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
TH_2331|M.thermoresistible__bu GLDRGPLPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
MAB_2872c|M.abscessus_ATCC_199 GLDRGQLPAKLRYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEV
**** **.** *:************* *******:**************
Mb2611c|M.bovis_AF2122/97 IAIADAGFRSLGLDGFRLEITSLGDESCRPQYRELLQEFLFGLDLDEDTR
Rv2580c|M.tuberculosis_H37Rv IAIADAGFRSLGLDGFRLEITSLGDESCRPQYRELLQEFLFGLDLDEDTR
MMAR_2127|M.marinum_M IAIADAGFRSLGLDGFRLEVTSLGDETCRPQYRELLQEFLFGLDLDDDTR
MUL_1732|M.ulcerans_Agy99 IAIADAGFRSLGLDGFRLEITSLGDETCRPQYRELLQEFLFGLDLDDETR
MLBr_00494|M.leprae_Br4923 ITIADAGFRSLGLDGFQLEITSLGDGTCRPQYRKLLQEFLLQLDLDEDTR
MAV_3460|M.avium_104 IAVADAGFRSLGLDGFRLEITSLGDDSCRPQYRELLQDFLFGLDLDEETR
Mvan_2590|M.vanbaalenii_PYR-1 IAVADAGFRSLGLDGFRLDITSLGDDSCRPQYRELLQEFLFKLDLDEETR
Mflv_3809|M.gilvum_PYR-GCK MAVADAGFRSLGLDGFRLEITSLGDDSCRPQYRELLQEFLFKLDLDEETR
MSMEG_2976|M.smegmatis_MC2_155 IAVADAGFRSLGLSGFRLEITSLGDDTCRPAYRELLQEFLFKLDLDEETR
TH_2331|M.thermoresistible__bu IAVADAGFRSLGLTDFRLEITSLGDETCRPQYRELLQEFLFKLDLDEETR
MAB_2872c|M.abscessus_ATCC_199 IAIADAGYRSLGLTGFRLEISSLGDASCRPQYRELLQEFLFGLDLDEATR
:::****:***** .*:*:::**** :*** **:***:**: ****: **
Mb2611c|M.bovis_AF2122/97 RRAGINPLRVLDDKRPELRAMTASAPVLLDHLSDVAKQHFDTVLAHLDAL
Rv2580c|M.tuberculosis_H37Rv RRAGINPLRVLDDKRPELRAMTASAPVLLDHLSDVAKQHFDTVLAHLDAL
MMAR_2127|M.marinum_M RRAALNPLRVLDDKRPEVRAMTAEAPVLLDHLSDVAKQHFDTVLAHLDAL
MUL_1732|M.ulcerans_Agy99 RRAALNPLRVLDDKRPEVRAMTAEAPVLLDHLSDVAKQHFDTVLAHLDAL
MLBr_00494|M.leprae_Br4923 RRAELNPLRVLDDKRPQVQAMTAAAPVLLDHLSDGAKQHFDTVLAHLDAL
MAV_3460|M.avium_104 RRARLNPLRVLDDKRPEVRAMTADAPVLLDHLSDAAKQHFDTVLAHLDAL
Mvan_2590|M.vanbaalenii_PYR-1 RRAEINPLRVLDDKRPHMKEMTADAPVMLDHLSDAAKQHFDTVLAHLDAL
Mflv_3809|M.gilvum_PYR-GCK QRAQLNPLRVLDDKRPHVREMTANAPVMLDHLSDAAKEHFDTVLAHLDAL
MSMEG_2976|M.smegmatis_MC2_155 RRAEINPLRVLDDKRPHVREMTADAPLMLDHLSDSAKEHFETVQTYLDAL
TH_2331|M.thermoresistible__bu RRAQINPLRVLDDKRPHVREMTADAPVMLDHLSDSAKQHFDTVLAYLDAL
MAB_2872c|M.abscessus_ATCC_199 ERARINPIRVLDDKRPEVREMTANAPLMLDHLSGEAKAHFEQVLSHLDAL
.** :**:********.:: *** **::*****. ** **: * ::****
Mb2611c|M.bovis_AF2122/97 GVPYVINPRMVRGLDYYTKTAFEFVHDGLGAQSGIGGGGRYDGLMHQLGG
Rv2580c|M.tuberculosis_H37Rv GVPYVINPRMVRGLDYYTKTAFEFVHDGLGAQSGIGGGGRYDGLMHQLGG
MMAR_2127|M.marinum_M RVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMKQLGG
MUL_1732|M.ulcerans_Agy99 RVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMKQLGG
MLBr_00494|M.leprae_Br4923 RVPYVINPRMVRGLDYYTKTTFEFVHPGLGAQSGIGGGGRYDGLMRQLGG
MAV_3460|M.avium_104 GVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMRQLGG
Mvan_2590|M.vanbaalenii_PYR-1 SVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMHQLGG
Mflv_3809|M.gilvum_PYR-GCK SVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMAQLGG
MSMEG_2976|M.smegmatis_MC2_155 GVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMRQLGG
TH_2331|M.thermoresistible__bu EVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMRQLGG
MAB_2872c|M.abscessus_ATCC_199 GVQYVVNPRLVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMAQLGG
* **:***:**********:***** ****************** ****
Mb2611c|M.bovis_AF2122/97 QDLSGIGFGLGVDRTVLALRAEGKTAGDSARCDVFGVPLGEAAKLRLAVL
Rv2580c|M.tuberculosis_H37Rv QDLSGIGFGLGVDRTVLALRAEGKTAGDSARCDVFGVPLGEAAKLRLAVL
MMAR_2127|M.marinum_M QDLSGIGFGLGVDRTMLALRAEGKSVGESARCDVFGVPLSEQAKLTLAVL
MUL_1732|M.ulcerans_Agy99 QDLSGIGFGLGVDRTMLALRAEGKSVGESARCDVFGVPLSEQAKLTLAVL
MLBr_00494|M.leprae_Br4923 QDLSGIGFGLGVDRTLLALHAEGKTVGETTRCDVFGVSLGEAAKLKVAML
MAV_3460|M.avium_104 QDLSGIGFGLGVDRTLLALRAEGKSVGSAARCDVFGVPLSDQAKLRLAVL
Mvan_2590|M.vanbaalenii_PYR-1 RDLSGIGFGLGVDRTLLALRAEGKTAGETARVDVYAVPLGGDAKVRLAVL
Mflv_3809|M.gilvum_PYR-GCK RDLSGIGFGLGVDRTLLALRAEGKAAGETARVDVYAVPLGADAKVRLAVL
MSMEG_2976|M.smegmatis_MC2_155 QDVSGIGFGLGVDRTLLALQAEGVTIEGAGGVEVFGVPLGAAAKLELAKL
TH_2331|M.thermoresistible__bu QDVSGIGFGLGVDRTMLALKAEGKQVGETARVQVFCVPLGAEAKLKLAVL
MAB_2872c|M.abscessus_ATCC_199 QSLSGIGFGLGVDRTVLALRAEGVTVGDSGRCEVFCVPLGQDAKSVLVKV
:.:************:***:*** : :*: *.*. ** :. :
Mb2611c|M.bovis_AF2122/97 AGRLRAAGVRVDLAYGDRGLKGAMRAAARSGARVALVAGDRDIEAGTVAV
Rv2580c|M.tuberculosis_H37Rv AGRLRAAGVRVDLAYGDRGLKGAMRAAARSGARVALVAGDRDIEAGTVAV
MMAR_2127|M.marinum_M AGQLRASGVRVDLAYGDRGLKGAMRAADRSGARVALVAGDRDIEAGTVGV
MUL_1732|M.ulcerans_Agy99 AGQLRASGVRVDLAYGDRGLKGAMRAADRSGARVALVTGDRDIEAGTVGV
MLBr_00494|M.leprae_Br4923 AGQLRAAGVRVDLIYGDRGIRGAMRAAGRSGARIALIVDDCAIKADGVGV
MAV_3460|M.avium_104 AAGLRAAGVRVDMAYGARGLKGAMRAADRSGARIALVLGDRDIDAGTVGV
Mvan_2590|M.vanbaalenii_PYR-1 AAQLRAAGVRVDVAYGDRSLKGAMKGADRSGASIALVAGDRDLEAGTVGM
Mflv_3809|M.gilvum_PYR-GCK AAQLRAAGVRVDVAYGDRSLKGAMKGADRSGASIALVAGDRDLEAGTVGV
MSMEG_2976|M.smegmatis_MC2_155 AAKLRAGGARVDLAYGDRGLKGAMKAADRSGAKYALVAGDRDIEAGTVGL
TH_2331|M.thermoresistible__bu AAKLRAAGIRVDMAYGDRGLKGAMRAADRSGAAVAVVAGDRDIEAGTFGV
MAB_2872c|M.abscessus_ATCC_199 AAQLRGAGIRTDIAYGDRGLKGAMRGADRSGASIALVAGDREIGEGNIEL
*. **..* *.*: ** *.::***:.* **** *:: .* : . . :
Mb2611c|M.bovis_AF2122/97 KDLTTGEQVSVSMDSVVAEVISRLAG--
Rv2580c|M.tuberculosis_H37Rv KDLTTGEQVSVSMDSVVAEVISRLAG--
MMAR_2127|M.marinum_M KDLGTGEQVSVSTDSVVDDVISKLGR--
MUL_1732|M.ulcerans_Agy99 KDLGTGEQVSVSTDSVVDDVISKLGR--
MLBr_00494|M.leprae_Br4923 RDLATGEQISVAVDSVVAEVISRIAPS-
MAV_3460|M.avium_104 KDLQTGSQVSVELDSVVAEVLSQLSR--
Mvan_2590|M.vanbaalenii_PYR-1 KSMATGEQVDVAVEGVVAEVLSRLS---
Mflv_3809|M.gilvum_PYR-GCK KSMATGEQVDVASDDVVAEVLSRLT---
MSMEG_2976|M.smegmatis_MC2_155 KDLSTGDQIDVPADSVVAEVLSRLGR--
TH_2331|M.thermoresistible__bu KDLASGEQVDVPMDAVLDDILARLN---
MAB_2872c|M.abscessus_ATCC_199 KTLADGVQQPVPIGSIVGEVTARLASRI
: : * * * :: :: :::