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NPNSVRPRRLHVSALAAVANPSYTRLDTWNLLDDACRHLAEVDLAGLDTTHDVARAKRLMDRIGAYERYW LYPGAQNLATFRAHLDSHSTVRLTEEVSLAVRLLSEYGDRTALFDTSASLAEQELVAQAKQQQFYTVLLA DDSPATAPDSLAECLRQLRNPADEVQFELLVVASIEDAITAVALNGEIQAAIIRHDLPLRSRDRVPLMTT LLGTDGDEAVANETHDWVECAEWIRELRPHIDLYLLTDESIAAETQDEPDVYDRTFYRLNDVTDLHSTVL AGLRNRYATPFFDALRAYAAAPVGQFHALPVARGASIFNSKSLHDMGEFYGRNIFMAETSTTSGGLDSLL DPHGNIKTAMDKAAVTWNANQTYFVTNGTSTANKIVVQALTRPGDIVLIDRNCHKSHHYGLVLAGAYPMY LDAYPLPQYAIYGAVPLRTIKQALLDLEAAGQLHRVRMLLLTNCTFDGVVYNPRRVMEEVLAIKPDICFL WDEAWYAFATAVPWARQRTAMIAAERLEQMLSTAEYAEEYRNWCASMDGVDRSEWVDHRLLPDPNRARVR VYATHSTHKSLSALRQASMIHVRDQDFKALTRDAFGEAFLTHTSTSPNQQLLASLDLARRQVDIEGFELV RHVYNMALVFRHRVRKDRLISKWFRILDESDLVPDAFRSSTVSSYRQVRQGALADWNEAWRSDQFVLDPT RLTLFIGATGMNGYDFREKILMERFGIQINKTSINSVLLIFTIGVTWSSVHYLLDVLRRVAIDLDRSQKA ASGADLALHRRHVEEITQDLPHLPDFSEFDLAFRPDDASSFGDMRSAFYAGYEEADREYVQIGLAGRRLA EGKTLVSTTFVVPYPPGFPVLVPGQLVSKEIIYFLAQLDVKEIHGYNPDLGLSVFTQAALARMEAARNAV ATVGAALPAFEVPRDASALNGTVNGDSVLQGVAEDA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2531c | - | - | 100% (947) | PROBABLE AMINO ACID DECARBOXYLASE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2560c | - | 0.0 | 100.00% (947) | amino acid decarboxylase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. leprae Br4923 | MLBr_00524 | adi | 0.0 | 86.44% (951) | putative amino acid decarboxylase |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2184 | - | 0.0 | 85.22% (947) | amino acid decarboxylase |
| M. avium 104 | MAV_3408 | - | 0.0 | 85.91% (944) | putative Orn/Lys/Arg decarboxylase |
| M. smegmatis MC2 155 | MSMEG_0266 | - | 9e-06 | 27.07% (133) | arginine decarboxylase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2916 | - | 6e-15 | 26.67% (360) | Orn/Lys/Arg decarboxylase, major region |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2531c|M.tuberculosis_H37Rv MNPNSVRPRRLHVSALAAVANPSYTRLDTWNLLDDACRHLAEVDLAGLDT
Mb2560c|M.bovis_AF2122/97 MNPNSVRPRRLHVSALAAVANPSYTRLDTWNLLDDACRHLAEVDLAGLDT
MLBr_00524|M.leprae_Br4923 MNRDSGHPRRLRVSALAAVANPSYTRIDTWNVLDDACRHLAEVDRAGLDT
MMAR_2184|M.marinum_M MKRYSTRPRRLRVSALAAVANPSYARVDTWNLLDDACCHLAEVDLAGMDI
MAV_3408|M.avium_104 MIRYSTQPRRLRVSALAAVANPSYARVDTWNLLDDACRHLAEVDLAGLDK
Mvan_2916|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0266|M.smegmatis_MC2_155 --------------------------------------------------
Rv2531c|M.tuberculosis_H37Rv THDVARAKRLMDRIGAYERYWLYPGAQNLATFRAHLDSHSTVRLTEEVSL
Mb2560c|M.bovis_AF2122/97 THDVARAKRLMDRIGAYERYWLYPGAQNLATFRAHLDSHSTVRLTEEVSL
MLBr_00524|M.leprae_Br4923 AHDVARVKRLLDRIGAYERYWLYPGAANLAAFRGYLATMATVQLTEEVSL
MMAR_2184|M.marinum_M THDMAKVRRLMDRIGAYERYWLYPGAQNLANFRAHLESKSTVRLKEEVSL
MAV_3408|M.avium_104 THDVARVKRLLDRIAAYERYWLYPGAENLAIFRAHLESLSTVRLTEEVSL
Mvan_2916|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0266|M.smegmatis_MC2_155 --------------------------------------------------
Rv2531c|M.tuberculosis_H37Rv AVRLLSEYGDRTALFDTSASLAEQELVAQAKQQQFYTVLLADDSPATAPD
Mb2560c|M.bovis_AF2122/97 AVRLLSEYGDRTALFDTSASLAEQELVAQAKQQQFYTVLLADDSPATAPD
MLBr_00524|M.leprae_Br4923 AVRLLSEYGDRTALFDTSAPLADQELVAQAKQQQFYTVLLADDAPSTAPD
MMAR_2184|M.marinum_M AVRLLGEYGDRTALFDTSAPLAEQELVAQAKQQQFYTVLVADDAPTSAPD
MAV_3408|M.avium_104 AVRLLSEYGDRAGLFDTSAPLDDQELVAQAKQQHFYTVLLADDAPSTAPD
Mvan_2916|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0266|M.smegmatis_MC2_155 --------------------------------------------------
Rv2531c|M.tuberculosis_H37Rv SLAECLRQLRNPADEVQFELLVVASIEDAITAVALNGEIQAAIIRHDLPL
Mb2560c|M.bovis_AF2122/97 SLAECLRQLRNPADEVQFELLVVASIEDAITAVALNGEIQAAIIRHDLPL
MLBr_00524|M.leprae_Br4923 CLAESLRELRNPSDDVQFELLVVSSVEDAITAVALNGEIQAAIIRHDLPL
MMAR_2184|M.marinum_M SLAEHLRALHNPSDDVQFEVLLAPSVEDAITAVALNGEIQAAIIRHDLPL
MAV_3408|M.avium_104 SLAECLRALRNPSDDVQFEILVVPSVEDAITAVALNGEIQAAIIRDDLPL
Mvan_2916|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0266|M.smegmatis_MC2_155 --------------------------------------------------
Rv2531c|M.tuberculosis_H37Rv RSRDRVPLMTTLLGTDGDE---AVANETHDWVECAEWIRELRPHIDLYLL
Mb2560c|M.bovis_AF2122/97 RSRDRVPLMTTLLGTDGDE---AVANETHDWVECAEWIRELRPHIDLYLL
MLBr_00524|M.leprae_Br4923 RSRDRVPLMNTLLGANDSEGALVTIDRPHDWVECGEWIRELRPHIDLYLL
MMAR_2184|M.marinum_M RSRDRLPLMNALLGAN--DDV-VAPDSPHDWIECGEWIRELRPHIDLYLL
MAV_3408|M.avium_104 RSRDRLPLMNTLLGPNEDADG-VIPDRANDWVECGEWIRELRPHIDLYLL
Mvan_2916|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0266|M.smegmatis_MC2_155 --------------------------------------------------
Rv2531c|M.tuberculosis_H37Rv TDESIAAETQDEPDVYDRTFYRLNDVTDLHSTVLAGLRNRYATPFFDALR
Mb2560c|M.bovis_AF2122/97 TDESIAAETQDEPDVYDRTFYRLNDVTDLHSTVLAGLRNRYATPFFDALR
MLBr_00524|M.leprae_Br4923 TDESIAAGNDDEPDVYDRTFYRLNDVTDLNSTVLAGLRNRFATPFFDALR
MMAR_2184|M.marinum_M TDESIAAGAEDDPDVYDRTFYRLNDVTDLHSTVLAGLRNRFATPFFDALR
MAV_3408|M.avium_104 TDESIAAGDDTEPDVYDRTFYRLNDVTDLHSTVLAGLRNRYATPFFDALR
Mvan_2916|M.vanbaalenii_PYR-1 ----------------------------------MGFEHS-RAPLFESLR
MSMEG_0266|M.smegmatis_MC2_155 -------------------------------------MDQTETPLLDALN
. :*::::*.
Rv2531c|M.tuberculosis_H37Rv AYAAAPVGQFHALPVARGASIFNSKSLHDMGEFYGRNIFMAETS---TTS
Mb2560c|M.bovis_AF2122/97 AYAAAPVGQFHALPVARGASIFNSKSLHDMGEFYGRNIFMAETS---TTS
MLBr_00524|M.leprae_Br4923 AYAAAPVGQFHALPVARGASIFNSRSLQDMGEFYGRNIFMAETS---TTS
MMAR_2184|M.marinum_M AYAAAPVGQFHALPVARGASIFNSKSLQDMGEFYGRNIFMAETS---TTS
MAV_3408|M.avium_104 AYAAAPVGQFHALPVARGASIFNSRSLQDMGEFYGRNIFMAETS---TTS
Mvan_2916|M.vanbaalenii_PYR-1 TFVERDQAPFYSP---------GHKGGRTIDPWLRENIAAVDLN---NLP
MSMEG_0266|M.smegmatis_MC2_155 EYHASNRYGYSPP---------GHRQGRGVDDRVLRVLGREPFLSDVLAN
: : . . : : :. . :
Rv2531c|M.tuberculosis_H37Rv GGLDSLLDPHGNIKTAMDKAAVTWNANQTYFVTNGTSTANKIVVQALTRP
Mb2560c|M.bovis_AF2122/97 GGLDSLLDPHGNIKTAMDKAAVTWNANQTYFVTNGTSTANKIVVQALTRP
MLBr_00524|M.leprae_Br4923 GGLDSLLDPHGNIKKAMDKAAVTWRANHTYFVTNGTSTANKIVVQSLTRP
MMAR_2184|M.marinum_M GGLDSLLDPHGNIKKAMDKAASTWNADHTYFVTNGTSTANKIVVQSLTRP
MAV_3408|M.avium_104 GGLDSLLDPHGNIKKAMDKAAKTWNADHTYFVTNGTSTANKIVVQSLTRP
Mvan_2916|M.vanbaalenii_PYR-1 -DTDTLHCPEGPILEAERLIADAWGVPQSFLMVQGSTGGNIAVALTALRP
MSMEG_0266|M.smegmatis_MC2_155 GGLDDRRSSNGYLQKAEDLMAEAVGADTAWFSTCGSSLSVKAAMMAVAGG
. * ..* : * * : . ::: . *:: . . :
Rv2531c|M.tuberculosis_H37Rv GDIVLIDRNCHKSHHYGLVLAGAYPMYLDAYPLPQYAIYGAVPLRTIKQA
Mb2560c|M.bovis_AF2122/97 GDIVLIDRNCHKSHHYGLVLAGAYPMYLDAYPLPQYAIYGAVPLRTIKQA
MLBr_00524|M.leprae_Br4923 GDIVLIDRNCHKSHHYGLVLAGAYPMYLDAYPLPQFAIYGAVSLRTIKKA
MMAR_2184|M.marinum_M GDIVLIDRNCHKSHHYGLVLAGAYPLYLDAYPLPPFAIYGAVSLHTIKQV
MAV_3408|M.avium_104 GDIVLIDRNCHKSHHYGLVLAGAYPLYLDAYPLPQFAIYGAVSLRTIKQT
Mvan_2916|M.vanbaalenii_PYR-1 DEPVLVARNAHKSVLAGLVQVGARPVWLEPRWDAEFGVAHGLDAAVVARA
MSMEG_0266|M.smegmatis_MC2_155 DGSLLLSRDSHKSVVAGLIFSGVMPRWITPRWDADRHLSHPPSPEEVEET
. :*: *:.*** **: *. * :: . . : : ..
Rv2531c|M.tuberculosis_H37Rv LLDLEAAGQLHRVRMLLLTNCTFDGVVYNPRRVMEEVLAIKPDICFLWDE
Mb2560c|M.bovis_AF2122/97 LLDLEAAGQLHRVRMLLLTNCTFDGVVYNPRRVMEEVLAIKPDICFLWDE
MLBr_00524|M.leprae_Br4923 LLDLEAVRQLDRVRMLLLTNCTFDGVVCNPQRVMEEVLAIKPDICFLWDE
MMAR_2184|M.marinum_M LLDLEAAGQLHKVRMLLLTNCTFDGVVYNPRLVMEEVLAIKPDICFLWDE
MAV_3408|M.avium_104 LLDLEAAGQLHRVRMLLLTNCTFDGVVYNPLQVMQEVLAIKPDICFLWDE
Mvan_2916|M.vanbaalenii_PYR-1 FETTGAT-------ALWALHPTYYGTTGD--------LAALADLCRRYGA
MSMEG_0266|M.smegmatis_MC2_155 WRRYPDAAG------ALIVSPSPYGTCAD--------LAGIADVCHARGK
. : *. : ** .*:* .
Rv2531c|M.tuberculosis_H37Rv AWYAFATAVPWARQRTAMIAAERLEQMLSTAEYAEEYRNWCASMDGVDRS
Mb2560c|M.bovis_AF2122/97 AWYAFATAVPWARQRTAMIAAERLEQMLSTAEYAEEYRNWCASMDGVDRS
MLBr_00524|M.leprae_Br4923 AWYAFATAVPWARQRTAMVSAEQLEQKLWSVEYAEEYRNWCASMAEIPRS
MMAR_2184|M.marinum_M AWYAFATAVPWARQRTAMVSAEYLESMLASDEYGAVYEKWRASMQGIPRS
MAV_3408|M.avium_104 AWYAFATAVPWARQRTAMVAAERLEQMLASPDYVEQYRKWAASMQGVDRS
Mvan_2916|M.vanbaalenii_PYR-1 R----------------------------------------LLLDGAHSP
MSMEG_0266|M.smegmatis_MC2_155 P----------------------------------------LIVDEAWGA
: .
Rv2531c|M.tuberculosis_H37Rv EWVDHRLLPDPNRARVRVYATHSTHKSLSALRQASMIHVRDQDFKALTRD
Mb2560c|M.bovis_AF2122/97 EWVDHRLLPDPNRARVRVYATHSTHKSLSALRQASMIHVRDQDFKALTRD
MLBr_00524|M.leprae_Br4923 QWVDQRLLPDPNRARIRVYATHSTHKSLSALRQASMIHVRDQDFNALARD
MMAR_2184|M.marinum_M QWAEHRLLPDPKRARVRVYATHSTHKSLSALRQASMIHVRDQDFNALTRD
MAV_3408|M.avium_104 EWIERELLPDPATARVRVYATHSTHKSLSALRQASMIHVRDQDFNALTRD
Mvan_2916|M.vanbaalenii_PYR-1 HFAFHPDLPTPGEQSGAAATVHSVHKILSGLSQAAVLHVDTAQLDEAS--
MSMEG_0266|M.smegmatis_MC2_155 HLPFHENLPTWAMNAGADVCVVSVHKMGAGFEQGSAFHLQG---DLIDQD
. : ** . *.** :.: *.: :*: .
Rv2531c|M.tuberculosis_H37Rv AFGEAFLTHTSTSPNQQLLASLDLARRQVDIEGFELVRHVYNMALVFRHR
Mb2560c|M.bovis_AF2122/97 AFGEAFLTHTSTSPNQQLLASLDLARRQVDIEGFELVRHVYNMALVFRHR
MLBr_00524|M.leprae_Br4923 AFGEAFLTHTSTSPNQQLLASLDLARRQVDIEGFQLVRLVYDMALVFRHR
MMAR_2184|M.marinum_M AFGEAFLTHTSTSPNQQLLASLDLARRQVDIEGFQLVRQVYDMALVFRHR
MAV_3408|M.avium_104 AFGEAFLTHTSTSPNQQLLASLDLARRQVDIEGFQLVRQVYDMALVFRHR
Mvan_2916|M.vanbaalenii_PYR-1 -VRRSLQLIQTTSPHFAIMASVDLARRQMVLDGHALLDATLTRAREAADR
MSMEG_0266|M.smegmatis_MC2_155 RLSACADLLMTTSPNVLVYSAIDGWRRQMVEHGHRLFGAALDLADDTRRR
. . :***: : :::* ***: .*. *. . * *
Rv2531c|M.tuberculosis_H37Rv VRKDRLISKWFRILDESDLVPDAFRSSTVSSYRQVRQGALADWNEAWRSD
Mb2560c|M.bovis_AF2122/97 VRKDRLISKWFRILDESDLVPDAFRSSTVSSYRQVRQGALADWNEAWRSD
MLBr_00524|M.leprae_Br4923 VRKDRLISKWFRILDESDLVPDEYRASAVSSYRQVRQGALAEWNEAWRSD
MMAR_2184|M.marinum_M VRKDRLISKWFRILDEADLVPEEFRASSVSSYRQVRQGALAEWNEAWRSD
MAV_3408|M.avium_104 VRKDRLISKWFRILDESDLVPEEFRASSVSSYREVRQGALAEWNEAWRSD
Mvan_2916|M.vanbaalenii_PYR-1 LS---------QVPGLTVLRPEHLAGAGTG--------------------
MSMEG_0266|M.smegmatis_MC2_155 IE----------EIDDVEVLDEELLGAQAS--------------------
: . : : .: ..
Rv2531c|M.tuberculosis_H37Rv QFVLDPTRLTLFIGATGMNGYDFREKILMERFGIQINKTSINSVLLIFTI
Mb2560c|M.bovis_AF2122/97 QFVLDPTRLTLFIGATGMNGYDFREKILMERFGIQINKTSINSVLLIFTI
MLBr_00524|M.leprae_Br4923 QFVLDPTRVTLFVGKTGMNGYDFREKILMERFGIQINKTSINSVLLIFTI
MMAR_2184|M.marinum_M QFVLDATRVTLFIGSTGMNGYDFREKILMERFGIQINKTSINSVLLIFTI
MAV_3408|M.avium_104 QFVLDATRVTLFVGATGMNGYDFREKILMERFGIQINKTSINSVLLIFTI
Mvan_2916|M.vanbaalenii_PYR-1 LCQLDETKLLVGTAGVDADARDILG-RLNRIHGVQPELAGAGHILCISTI
MSMEG_0266|M.smegmatis_MC2_155 -HDLDRLQILIDVSATGTSGYQAAD-WLRENCQVDVGMSDHRRILATMSV
** :: : . .. .. : * . :: :. :* ::
Rv2531c|M.tuberculosis_H37Rv GVTWSSVHYLLDVLRRVAIDLDRSQKAASGADLALHRRHVEEITQDLPHL
Mb2560c|M.bovis_AF2122/97 GVTWSSVHYLLDVLRRVAIDLDRSQKAASGADLALHRRHVEEITQDLPHL
MLBr_00524|M.leprae_Br4923 GVTWSSVHYLLDVLRRVASDFDRIQKVASGADLALHQRHVEEITQDLPHL
MMAR_2184|M.marinum_M GVTWSSVHYLLDVLRRIATDFDRSQRAASAADWALHERRVEEITQDLPHL
MAV_3408|M.avium_104 GVTWSSVHYLLDVLRRVATDFDRIQKEASAADRALQRRHVEEITEDLPHL
Mvan_2916|M.vanbaalenii_PYR-1 GNIDDDFYRLTTAFEEVSAHFGRRDAEGAG--------------------
MSMEG_0266|M.smegmatis_MC2_155 ADGSDTAGRLLHALSLWRKAADDFAPPPPID------------------L
. . * .: . .
Rv2531c|M.tuberculosis_H37Rv PDFSEFDLAFRPDDASSFGDMRSAFYAGYEEADREYVQIGLAGRRLAEGK
Mb2560c|M.bovis_AF2122/97 PDFSEFDLAFRPDDASSFGDMRSAFYAGYEEADREYVQIGLAGRRLAEGK
MLBr_00524|M.leprae_Br4923 PDFSEFDVAFRPENASSFGDMRSAFYAGYEESDREYVHIGTAGRQLAEGR
MMAR_2184|M.marinum_M PDFSEFDIAFRPDDASSFGDMRSAFYAGYDESDREYVQIGMAGRRLAEGR
MAV_3408|M.avium_104 PDFSEFDVAFRPVDECNFGDMRSAFYAGYEESDREHVLIGTAGRRLAEGK
Mvan_2916|M.vanbaalenii_PYR-1 -AWTADVLAVRPELVLTP---REAFFAADET------------VALADAA
MSMEG_0266|M.smegmatis_MC2_155 PSPAELQLTTKTS-------PRDAFFAEVEQ------------IPVEHAV
: :: :. *.**:* : : ..
Rv2531c|M.tuberculosis_H37Rv TLVSTTFVVPYPPGFPVLVPGQLVSKEIIYFLAQLDVKEIHGYN-PDLGL
Mb2560c|M.bovis_AF2122/97 TLVSTTFVVPYPPGFPVLVPGQLVSKEIIYFLAQLDVKEIHGYN-PDLGL
MLBr_00524|M.leprae_Br4923 TLVSTTFVVPYPPGFPVLVPGQVVSKEIIYFLAQLDVKEIHGYN-HELGL
MMAR_2184|M.marinum_M TLVSTTFVVPYPPGFPVLVPGQVVSKEIVYFLAQLDVKEIHGYN-HELGL
MAV_3408|M.avium_104 NLVSTTFVVPYPPGFPVLVPGQVVSKEIVYFLAQLDVKEIHGYN-PDLGL
Mvan_2916|M.vanbaalenii_PYR-1 GRIAAEAITPYPPGIPVVMPGERLGKDVVDLLLRLRAAGNPISA-SDPTM
MSMEG_0266|M.smegmatis_MC2_155 GRIAAEQITPYPPGIPAVVPGERLNEAVLDYLVTGVQAGMNLPDPADPQM
::: :.*****:*.::**: :.: :: * : :
Rv2531c|M.tuberculosis_H37Rv SVFTQAALARMEAARN-AVATVGAALPAFEVPRDASALNGTVNGDSVLQG
Mb2560c|M.bovis_AF2122/97 SVFTQAALARMEAARN-AVATVGAALPAFEVPRDASALNGTVNGDSVLQG
MLBr_00524|M.leprae_Br4923 SVFTEKALARMIARRNAASAAVGSAFAAFEIPSDSAAMGGDVNGD-RVEA
MMAR_2184|M.marinum_M SVFTDVALKRMEAARN-VIASAGAELPAFELAPASS----VVNGDGVLQA
MAV_3408|M.avium_104 SVFTDTALARMEAQRNAATAAVGSVTAAFELPADASGGNGAHNGAGAVPS
Mvan_2916|M.vanbaalenii_PYR-1 GVVKTVR-------------------------------------------
MSMEG_0266|M.smegmatis_MC2_155 GSIRVMA-------------------------------------------
. .
Rv2531c|M.tuberculosis_H37Rv VAEDA
Mb2560c|M.bovis_AF2122/97 VAEDA
MLBr_00524|M.leprae_Br4923 VAEDA
MMAR_2184|M.marinum_M VADDA
MAV_3408|M.avium_104 VADGG
Mvan_2916|M.vanbaalenii_PYR-1 -----
MSMEG_0266|M.smegmatis_MC2_155 -----