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TIHEHDRVSADRGGDSPHTTHALVDRLMAGEPYAVAFGGQGSAWLETLEELVSATGIETELATLVGEAEL LLDPVTDELIVVRPIGFEPLQWVRALAAEDPVPSDKHLTSAAVSVPGVLLTQIAATRALARQGMDLVATP PVAMAGHSQGVLAVEALKAGGARDVELFALAQLIGAAGTLVARRRGISVLGDRPPMVSVTNADPERIGRL LDEFAQDVRTVLPPVLSIRNGRRAVVITGTPEQLSRFELYCRQISEKEEADRKNKVRGGDVFSPVFEPVQ VEVGFHTPRLSDGIDIVAGWAEKAGLDVALARELADAILIRKVDWVDEITRVHAAGARWILDLGPGDILT RLTAPVIRGLGIGIVPAATRGGQRNLFTVGATPEVARAWSSYAPTVVRLPDGRVKLSTKFTRLTGRSPIL LAGMTPTTVDAKIVAAAANAGHWAELAGGGQVTEEIFGNRIEQMAGLLEPGRTYQFNALFLDPYLWKLQV GGKRLVQKARQSGAAIDGVVISAGIPDLDEAVELIDELGDIGISHVVFKPGTIEQIRSVIRIATEVPTKP VIMHVEGGRAGGHHSWEDLDDLLLATYSELRSRANITVCVGGGIGTPRRAAEYLSGRWAQAYGFPLMPID GILVGTAAMATKESTTSPSVKRMLVDTQGTDQWISAGKAQGGMASSRSQLGADIHEIDNSASRCGRLLDE VAGDAEAVAERRDEIIAAMAKTAKPYFGDVADMTYLQWLRRYVELAIGEGNSTADTASVGSPWLADTWRD RFEQMLQRAEARLHPQDFGPIQTLFTDAGLLDNPQQAIAALLARYPDAETVQLHPADVPFFVTLCKTLGK PVNFVPVIDQDVRRWWRSDSLWQAHDARYDADAVCIIPGTASVAGITRMDEPVGELLDRFEQAAIDEVLG AGVEPKDVASRRLGRADVAGPLAVVLDAPDVRWAGRTVTNPVHRIADPAEWQVHDGPENPRATHSSTGAR LQTHGDDVALSVPVSGTWVDIRFTLPANTVDGGTPVIATEDATSAMRTVLAIAAGVDSPEFLPAVANGTA TLTVDWHPERVADHTGVTATFGEPLAPSLTNVPDALVGPCWPAVFAAIGSAVTDTGEPVVEGLLSLVHLD HAARVVGQLPTVPAQLTVTATAANATDTDMGRVVPVSVVVTGADGAVIATLEERFAILGRTGSAELADPA RAGGAVSANATDTPRRRRRDVTITAPVDMRPFAVVSGDHNPIHTDRAAALLAGLESPIVHGMWLSAAAQH AVTATDGQARPPARLVGWTARFLGMVRPGDEVDFRVERVGIDQGAEIVDVAARVGSDLVMSASARLAAPK TVYAFPGQGIQHKGMGMEVRARSKAARKVWDTADKFTRDTLGFSVLHVVRDNPTSIIASGVHYHHPDGVL YLTQFTQVAMATVAAAQVAEMREQGAFVEGAIACGHSVGEYTALACVTGIYQLEALLEMVFHRGSKMHDI VPRDELGRSNYRLAAIRPSQIDLDDADVPAFVAGIAESTGEFLEIVNFNLRGSQYAIAGTVRGLEALEAE VERRRELTGGRRSFILVPGIDVPFHSRVLRVGVAEFRRSLDRVMPRDADPDLIIGRYIPNLVPRLFTLDR DFIQEIRDLVPAEPLDEILADYDTWLRERPREMARTVFIELLAWQFASPVRWIETQDLLFIEEAAGGLGV ERFVEIGVKSSPTVAGLATNTLKLPEYAHSTVEVLNAERDAAVLFATDTDPEPEPEEDEPVAESPAPDVV SEAAPVAPAASSAGPRPDDLVFDAADATLALIALSAKMRIDQIEELDSIESITDGASSRRNQLLVDLGSE LNLGAIDGAAESDLAGLRSQVTKLARTYKPYGPVLSDAINDQLRTVLGPSGKRPGAIAERVKKTWELGEG WAKHVTVEVALGTREGSSVRGGAMGHLHEGALADAASVDKVIDAAVASVAARQGVSVALPSAGSGGGATI DAAALSEFTDQITGREGVLASAARLVLGQLGLDDPVNALPAAPDSELIDLVTAELGADWPRLVAPVFDPK KAVVFDDRWASAREDLVKLWLTDEGDIDADWPRLAERFEGAGHVVATQATWWQGKSLAAGRQIHASLYGR IAAGAENPEPGRYGGEVAVVTGASKGSIAASVVARLLDGGATVIATTSKLDEERLAFYRTLYRDHARYGA ALWLVAANMASYSDVDALVEWIGTEQTESLGPQSIHIKDAQTPTLLFPFAAPRVVGDLSEAGSRAEMEMK VLLWAVQRLIGGLSTIGAERDIASRLHVVLPGSPNRGMFGGDGAYGEAKSALDAVVSRWHAESSWAARVS LAHALIGWTRGTGLMGHNDAIVAAVEEAGVTTYSTDEMAALLLDLCDAESKVAAARSPIKADLTGGLAEA NLDMAELAAKAREQMSAAAAVDEDAEAPGAIAALPSPPRGFTPAPPPQWDDLDVDPADLVVIVGGAEIGP YGSSRTRFEMEVENELSAAGVLELAWTTGLIRWEDDPQPGWYDTESGEMVDESELVQRYHDAVVQRVGIR EFVDDGAIDPDHASPLLVSVFLEKDFAFVVSSEADARAFVEFDPEHTVIRPVPDSTDWQVIRKAGTEIRV PRKTKLSRVVGGQIPTGFDPTVWGISADMAGSIDRLAVWNMVATVDAFLSSGFSPAEVMRYVHPSLVANT QGTGMGGGTSMQTMYHGNLLGRNKPNDIFQEVLPNIIAAHVVQSYVGSYGAMIHPVAACATAAVSVEEGV DKIRLGKAQLVVAGGLDDLTLEGIIGFGDMAATADTSMMCGRGIHDSKFSRPNDRRRLGFVEAQGGGTIL LARGDLALRMGLPVLAVVAFAQSFGDGVHTSIPAPGLGALGAGRGGKDSPLARALAKLGVAADDVAVISK HDTSTLANDPNETELHERLADALGRSEGAPLFVVSQKSLTGHAKGGAAVFQMMGLCQILRDGVIPPNRSL DCVDDELAGSAHFVWVRDTLRLGGKFPLKAGMLTSLGFGHVSGLVALVHPQAFIASLDPAQRADYQRRAD ARLLAGQRRLASAIAGGAPMYQRPGDRRFDHHAPERPQEASMLLNPAARLGDGEAYIG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv2524c | fas | - | 100% (3069) | PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) |
M. tuberculosis H37Rv | Rv2245 | kasA | 1e-19 | 28.00% (300) | 3-oxoacyl-(acyl carrier protein) synthase II |
M. tuberculosis H37Rv | Rv2246 | kasB | 3e-18 | 29.07% (289) | 3-oxoacyl-(acyl carrier protein) synthase II |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2553c | fas | 0.0 | 99.97% (3069) | fatty acid synthase |
M. gilvum PYR-GCK | Mflv_2532 | - | 0.0 | 78.67% (3085) | dehydratase |
M. leprae Br4923 | MLBr_01191 | fas | 0.0 | 85.84% (3080) | fatty acid synthase |
M. abscessus ATCC 19977 | MAB_1512 | - | 0.0 | 77.40% (3093) | fatty acid synthase Fas |
M. marinum M | MMAR_3962 | fas | 0.0 | 90.46% (3072) | fatty acid synthase Fas |
M. avium 104 | MAV_1650 | - | 0.0 | 88.67% (3089) | fatty acid synthase |
M. smegmatis MC2 155 | MSMEG_4757 | - | 0.0 | 81.80% (3088) | fatty acid synthase |
M. thermoresistible (build 8) | TH_1319 | fas | 0.0 | 82.08% (1289) | PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) |
M. ulcerans Agy99 | MUL_3818 | fas | 0.0 | 90.30% (3072) | fatty acid synthase Fas |
M. vanbaalenii PYR-1 | Mvan_4125 | - | 0.0 | 78.46% (3096) | dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_2532|M.gilvum_PYR-GCK --MTINDQHRATT----DSNGRPDKDFEPLTGTHALVDRFHSGEPYAVAF Mvan_4125|M.vanbaalenii_PYR-1 --MTINDQHRATT----DSDGQVAQGFEPLTGTHALVDRLHSGEPYAVAF TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 --MTIYEHDRVPAGWNDESGSDRTADGNAADTAHALVDRLSAGEPYAVAF Rv2524c|M.tuberculosis_H37Rv --MTIHEHDRVSADR--GGDSPH--------TTHALVDRLMAGEPYAVAF Mb2553c|M.bovis_AF2122/97 --MTIHEHDRVSADR--GGDSPH--------TTHALVDRLMAGEPYAVAF MMAR_3962|M.marinum_M --MTIHEHDRVSADR--DETGPH--------STHALVDRLTTGEPFAVAF MUL_3818|M.ulcerans_Agy99 MNVTIHEHDRVSADR--DETGPH--------STHALVDRLTAGEPFAVAF MLBr_01191|M.leprae_Br4923 --MTIHEHDQVSADR--NGNSLH--------GSRALADRLKAGEPYVVAF MAV_1650|M.avium_104 --MTIHEHDRVSADR--DGQGPHGVKHPPAGDTHALVDRLAAGEPYAVAF MAB_1512|M.abscessus_ATCC_1997 --MTINEYDKVTSSEDPDANGAVDPG---PSAGPALIDRLESGEPYAVAF Mflv_2532|M.gilvum_PYR-GCK GGQGGPWLENLEELVNSAGIESEISQLVAEAELLLEPLARELVVVRPIGF Mvan_4125|M.vanbaalenii_PYR-1 GGQGGPWLENLEELVNSAGIESEISQLVAEAELMLEPLARELVVVRPIGF TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 GGQGSAWLETLEELVSSAGIESELATLAGEAELLLEPVASELVVVRPIGF Rv2524c|M.tuberculosis_H37Rv GGQGSAWLETLEELVSATGIETELATLVGEAELLLDPVTDELIVVRPIGF Mb2553c|M.bovis_AF2122/97 GGQGSAWLETLEELVSATGIETELATLVGEAELLLDPVTDELIVVRPIGF MMAR_3962|M.marinum_M GGQGSAWLETLEELVSAAGIESELAALVGEVELLLEPVSKELVVVRPIGF MUL_3818|M.ulcerans_Agy99 GGQGSAWLETLEELVSAPGIESELAALVGEVELLLEPVSKELVVVRPIGF MLBr_01191|M.leprae_Br4923 GGQGSAWLETLEELVSSAGLEADLATLVCEVELLLEPVAKELVVVRPIGF MAV_1650|M.avium_104 GGQGSAWLETLEELVSSAGIEPELATLVGEVDLLLEPVAKELVVVRPIGF MAB_1512|M.abscessus_ATCC_1997 GGQGSDWLESLADLAASAGIESELATLAGEAELRLEPVAKELVVVRPVGF Mflv_2532|M.gilvum_PYR-GCK EPMRWIRALAAEEPLPSTKDLTTAAISGPGILLTQMAAQRALKRQGLDLD Mvan_4125|M.vanbaalenii_PYR-1 EPMKWIRALAADEPLPAAKDLTTAAISGPGILLTQMAAQRALKRQGLDLD TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 EPLQWVRALAAEEPVPSDKQLTSAAVSVPGVLLTQIAAVRALARQGMDLT Rv2524c|M.tuberculosis_H37Rv EPLQWVRALAAEDPVPSDKHLTSAAVSVPGVLLTQIAATRALARQGMDLV Mb2553c|M.bovis_AF2122/97 EPLQWVRALAAEDPVPSDKHLTSAAVSVPGVLLTQIAATRALARQGMDLV MMAR_3962|M.marinum_M EPLQWVRALAAEDPVPSDKHLTSSAVSLPGVLLTQVAAVRALARQGMDLI MUL_3818|M.ulcerans_Agy99 EPLQWVRALAAEDPVPSDKHLTSSAVSLPGVLLTQVAAVRALARQGMDLI MLBr_01191|M.leprae_Br4923 EPLQWVRALLAEDLVPSDKHLTSAAVSVPGVLLTQIAVGRALARQGMDLI MAV_1650|M.avium_104 EPLSWVRALAAEDPVPSNKHLTSAAVSIPGVLLTQIAAVRALARQGMDLT MAB_1512|M.abscessus_ATCC_1997 SPLTWVRALTAEEPVPAAAQLTSAAVSMPGVLLAQLAAVRALKIQGLDLA Mflv_2532|M.gilvum_PYR-GCK AHPPVAVAGHSQGVTAVESLKAGGARDVELLAIGQLIGAAGSLVSRRCGM Mvan_4125|M.vanbaalenii_PYR-1 GHPPVAIAGHSQGVTAVESLKAGGTRDVELLAIGQLIGAAGSLVSRRCGM TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 ATPPVAVAGHSQGVLAVQALAAKGAKDVELLALAQLIGAAGTLVARRRGI Rv2524c|M.tuberculosis_H37Rv ATPPVAMAGHSQGVLAVEALKAGGARDVELFALAQLIGAAGTLVARRRGI Mb2553c|M.bovis_AF2122/97 ATPPVAMAGHSQGVLAVEALKAGGARDVELFALAQLIGAAGTLVARRRGI MMAR_3962|M.marinum_M ATPPVVSVGHSQGVLAVEALNAGGARDVELLALAQLIGAAGTLVARRRGI MUL_3818|M.ulcerans_Agy99 ATPPVVSVGHSQGVLAVEALNAGGARDVELLALAQLIGAAGTLVARRRGI MLBr_01191|M.leprae_Br4923 ATPPVGIVGHSQGVLAVEALKAGGARDAELLAMAQLIGAAGTLVARRRGI MAV_1650|M.avium_104 ATPPVAVAGHSQGVLAVEALKGAGARDVELLALAQLIGAAGTLVARRRGI MAB_1512|M.abscessus_ATCC_1997 QLPPVAVIGHSQGVLAVEALKAHGARDVELLAIAQLVGAAATLVARRRGI Mflv_2532|M.gilvum_PYR-GCK VSRGDKAPMVSVLNVDPARIAELLEEFAQDVRTVLPPALSIRNGRRSVVI Mvan_4125|M.vanbaalenii_PYR-1 VGRGDKSPMVSVLNVDPARIAELLHDFAQDVRTVLPPALSIRNGRRSVVI TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 TVLGDRPPMVSVTNADPERIYELLEEFSSDVRTVLPPVLSIRNGRRSVVI Rv2524c|M.tuberculosis_H37Rv SVLGDRPPMVSVTNADPERIGRLLDEFAQDVRTVLPPVLSIRNGRRAVVI Mb2553c|M.bovis_AF2122/97 SVLGDRPPMVSVTNADPERIGRLLDEFAQDVRTVLPPVLSIRNGRRAVVI MMAR_3962|M.marinum_M SVLGDRPPMVSVTNADPERIQQLLEDFAQDVRTVLPPVLSIRNGRRSVVI MUL_3818|M.ulcerans_Agy99 SVLGDRPPMVSVTNADPERIQQLLEDFAQDVRTVLPPVLSIRSGRRSVVI MLBr_01191|M.leprae_Br4923 SVLGDRPPMVSVTNADPERIRRLLDEFAQDVRTVLPPVLSIRNGWRSVVI MAV_1650|M.avium_104 SVLGDRPPMVSVTNADPERISRLLDEFAQDVRTVLPPVLSIRNGRRSVVI MAB_1512|M.abscessus_ATCC_1997 VVRGNRTPMVSVTNVDPERMKALLDEFAQDVRTVQPPALSIRNGRRSVVI Mflv_2532|M.gilvum_PYR-GCK TGTPEQLARFELYCEKITEKEEAERKNKTRGGAIFRPVFNQLSVEVGFHT Mvan_4125|M.vanbaalenii_PYR-1 TGTPEQLARFELYCEKITEKEEAERKNKVRGGAIFRPVFNQLNVEVGFHT TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 TGTPEQLSRFELYCTQIAEKEEAERKNKLRGGAVFAPVFDPVQVEVGFHT Rv2524c|M.tuberculosis_H37Rv TGTPEQLSRFELYCRQISEKEEADRKNKVRGGDVFSPVFEPVQVEVGFHT Mb2553c|M.bovis_AF2122/97 TGTPEQLSRFELYCRQISEKEEADRKNKVRGGDVFSPVFEPVQVEVGFHT MMAR_3962|M.marinum_M TGTPEQLSRFELYCRQISEKEEAERKSKVRGGDVFAPVFDPVKVEVGFHT MUL_3818|M.ulcerans_Agy99 TGTPEQLSRFELYCRQISEKEEAERKSKVRGGDVFAPVFDPVKVEVGFHT MLBr_01191|M.leprae_Br4923 TGTPEQLSRFERYCRQISDKEEEDRRKKIRGGDIFAPVFDPVQVEIGFHT MAV_1650|M.avium_104 TGTPEQLSRFELYCRQISEKEEAERKNKLRGGDVFAPVFDPVQVEVGFHT MAB_1512|M.abscessus_ATCC_1997 TGTPEQLSRFELYCEQIAEREAAERKDKVRGGAIFSPVFDPVDVEVGFHT Mflv_2532|M.gilvum_PYR-GCK PRLAGGVDLVNEWASRTGLDRELTRTLAETIFVNPVDWVAEVEGLAATGA Mvan_4125|M.vanbaalenii_PYR-1 PRLAGGVELVNEWASRTGLDRELTRKLTEAIFIDPVDWVSEVEGLAEAGA TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 PRLSDGIEIVGRWAETVGLDVELAKELTESILVRQVDWVDEITELHEAGA Rv2524c|M.tuberculosis_H37Rv PRLSDGIDIVAGWAEKAGLDVALARELADAILIRKVDWVDEITRVHAAGA Mb2553c|M.bovis_AF2122/97 PRLSDGIDIVAGWAEKAGLDVALARELADAILIRKVDWVDEITRVHAAGA MMAR_3962|M.marinum_M PRLADGIDIVGGWAEKVGLDVALARQLAEAILVDTVDWVSDINRVHEAGA MUL_3818|M.ulcerans_Agy99 PRLADGIDIVGGWAEKVGLDVALARQLAEAILVDTVDWVSDINRVHEAGA MLBr_01191|M.leprae_Br4923 PHLADGIGIVGGWAEKVGLDVTLARELTEAILVRGVDWVREITRVHGAGV MAV_1650|M.avium_104 PRLADGIDIVGGWAEKVGLDVALARELTEAILVRRVDWVQEITRVHESGA MAB_1512|M.abscessus_ATCC_1997 PRLADGVEIAGRWAAAAGLDVELTKSLTEAILVTPVDWVNEVNHVADAGA Mflv_2532|M.gilvum_PYR-GCK KWIVDLGPSDTVTRLTAPVIRGLGIGIVPAATRAGQRSLFTVGAAPAVAP Mvan_4125|M.vanbaalenii_PYR-1 KWIVDLGPSDTVTRLTAPVIRGLGIGIVAAATRAGQRSLFTVGAAPAVAP TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 RWILDLGPGDILTRLTAPVIRGLGIGIVPAATRGGQRNLFTVGAVPEVAR Rv2524c|M.tuberculosis_H37Rv RWILDLGPGDILTRLTAPVIRGLGIGIVPAATRGGQRNLFTVGATPEVAR Mb2553c|M.bovis_AF2122/97 RWILDLGPGDILTRLTAPVIRGLGIGIVPAATRGGQRNLFTVGATPEVAR MMAR_3962|M.marinum_M RWILDLGPGDILTRLTASVIRGLGIGIVPAATRGGQRNLFTVGATPEVAR MUL_3818|M.ulcerans_Agy99 RWILDLGPGDILTRLTAPVIRGSGIGIVPAATRGGQRNLFTVGATPEVAR MLBr_01191|M.leprae_Br4923 RWIIDLGPGDILTRLTAPVIRGLGVGIVPVANRGGQRTLFTVGAVPEVVR MAV_1650|M.avium_104 RWILDLGPGDILTRLTAPVIRGLGVGIVPAATRGGQRNLFTVGAVPEVAR MAB_1512|M.abscessus_ATCC_1997 RWILDLGPGDLLTRLTAPVIRGLGIGIVPTATRGGQRNLFMHGAVPEVAR Mflv_2532|M.gilvum_PYR-GCK AWASYAPKPVALPDGSVKASTKFTRLTGRSPILLAGMTPTTVDAKIVAAA Mvan_4125|M.vanbaalenii_PYR-1 AWSSYAPQPIALPDGSVKASTKFTRLTGRSPILLAGMTPTTVDAKIVAAA TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 PWSSYAPTVVKLPDGSVKLETKFTRLTGRSPILLAGMTPTTVDAKIVAAA Rv2524c|M.tuberculosis_H37Rv AWSSYAPTVVRLPDGRVKLSTKFTRLTGRSPILLAGMTPTTVDAKIVAAA Mb2553c|M.bovis_AF2122/97 AWSSYAPTVVRLPDGRVKLSTKFTRLTGRSPILLAGMTPTTVDAKIVAAA MMAR_3962|M.marinum_M AWSSYAPTAVRLPDGRVKLSTKFTRLTGRSPILLAGMTPTTVDAKIVAAA MUL_3818|M.ulcerans_Agy99 AWSSYAPTAVRLPDGRVKLSTKFTRLTGRSPILLAGMTPTTVDAKIVAAA MLBr_01191|M.leprae_Br4923 AWLSYAPTVVQLPDGRIKLSTKFTRLTGRSPILLAGMTPTTVDANIVAAA MAV_1650|M.avium_104 AWSSYAPTLVRLPDGRVKLSTKFTRLTGRSPILLAGMTPTTVDAKIVAAA MAB_1512|M.abscessus_ATCC_1997 AWTSFAPTVVSLPDGSVKLSTKFTRLTGRSPILLAGMTPTTVDAKIVAAA Mflv_2532|M.gilvum_PYR-GCK ANAGHWAELAGGGQVTEEIFDARIEELTELLEPGRAIQFNSLFLDPYLWK Mvan_4125|M.vanbaalenii_PYR-1 ANAGHWAELAGGGQVTEEIFDARIKELTQLLEPGRAIQFNSLFLDPYLWK TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 ANAGHWAELAGGGQVTEQIFNDRIAELETLLEPGRAIQFNTLFLDPYLWK Rv2524c|M.tuberculosis_H37Rv ANAGHWAELAGGGQVTEEIFGNRIEQMAGLLEPGRTYQFNALFLDPYLWK Mb2553c|M.bovis_AF2122/97 ANAGHWAELAGGGQVTEEIFGNRIEQMAGLLEPGRTYQFNALFLDPYLWK MMAR_3962|M.marinum_M ANAGHWAELAGGGQVTEEIFADRINEMSGLLEPGRTYQFNALFLDPYLWK MUL_3818|M.ulcerans_Agy99 ANAGHWAELAGGGQVTEEIFADRINEMSGLLEPGRTYQFNALFLDPYLWK MLBr_01191|M.leprae_Br4923 ANAGHWAELAGGGQVTEEIFANRVEQLSGLLEPGRTYQFNALFLDPYLWK MAV_1650|M.avium_104 ANAGHWAELAGGGQVTEEIFAARIEELSGLLEEGRTYQFNALFLDPYLWK MAB_1512|M.abscessus_ATCC_1997 ANAGHWSELAGGGQVTEEIFSKRIEELTGLLEPGRQIQFNSLFLDPYLWK Mflv_2532|M.gilvum_PYR-GCK LQIGGKRLVQKARQSGAPIDGVVVTAGIPDLEEAVELIEELHTVGISNIV Mvan_4125|M.vanbaalenii_PYR-1 LQVGGKRLVQKARQSGAPIDGVVVTAGIPDLEEAVELIEELHTVGISNVV TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 LQVGGKRLVQRARQSGAPIDGLVVSAGIPDLEEAVDIIDELNEVGISHVV Rv2524c|M.tuberculosis_H37Rv LQVGGKRLVQKARQSGAAIDGVVISAGIPDLDEAVELIDELGDIGISHVV Mb2553c|M.bovis_AF2122/97 LQVGGKRLVQKARQSGAAIDGVVISAGIPDLDEAVELIDELGDIGISHVV MMAR_3962|M.marinum_M LQLGGKRLVQKARQSGAAIDGVVISAGIPDLEEAVELIDELNDIGISHVV MUL_3818|M.ulcerans_Agy99 LQLGGKRLVQKARQSGAAIDGVVISAGIPDLEEAVELIDELNDIGISHVV MLBr_01191|M.leprae_Br4923 LQVGGKRLVQKARQSGAAIDGVVISGGILDLEDAVELIEELGGIGISYVV MAV_1650|M.avium_104 LQVGGKRLVQKARQSGAAIDGLVISAGIPELEEAVELIEELGDVGISNIV MAB_1512|M.abscessus_ATCC_1997 LQVGSKRLVQKARQAGAPIDGVVVTAGIPELEEAVALIDELTEIGFSHIV Mflv_2532|M.gilvum_PYR-GCK FKPGTVDQIKSVIKIAVEVPDRDVIVHVEGGRAGGHHSWEDLDDLLISTY Mvan_4125|M.vanbaalenii_PYR-1 FKPGTVDQIKSVIKIAAEVPGRDVIVHIEGGRAGGHHSWEDLDDLLLTTY TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 FKPGTVEQIRSVIRIAAEVPTKPVIVHIEGGRAGGHHSWEDLDDLLLATY Rv2524c|M.tuberculosis_H37Rv FKPGTIEQIRSVIRIATEVPTKPVIMHVEGGRAGGHHSWEDLDDLLLATY Mb2553c|M.bovis_AF2122/97 FKPGTIEQIRSVIRIATEVPTKPVIMHVEGGRAGGHHSWEDLDDLLLATY MMAR_3962|M.marinum_M FKPGTIEQIRSVIRIATEVPTKPVIMHVEGGRAGGHHSWEDLDDLLLATY MUL_3818|M.ulcerans_Agy99 FKPGTIEQIRSVIRIATEVPTKPVIMHVEGGRAGGHHSWEDLDDLLLATY MLBr_01191|M.leprae_Br4923 FKPGTIEQIRSVIRIATEMSTKPVIMHVEGGRAGGHHSWEDLDDLLLATY MAV_1650|M.avium_104 FKPGTVEQIRSVIRIATEVSTKPVIVHIEGGRAGGHHSWEDLDDLLLATY MAB_1512|M.abscessus_ATCC_1997 FKPGTVEQIRSVVRIAAEVPTRPIIMHVEGGRAGGHHSWEDLDDLLLTTY Mflv_2532|M.gilvum_PYR-GCK GELRKYSNITICVGGGIGTPERAADYLSGEWAQAYGFPAMPVDGILVGTA Mvan_4125|M.vanbaalenii_PYR-1 GELRKYSNVTICVGGGIGTPERAAEYLSGEWAKAYGFPDMPVDGILVGTA TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 SELRSRSNITICVGGGIGTPERSAEYLSGRWAEVHGYPLMPIDGILVGTA Rv2524c|M.tuberculosis_H37Rv SELRSRANITVCVGGGIGTPRRAAEYLSGRWAQAYGFPLMPIDGILVGTA Mb2553c|M.bovis_AF2122/97 SELRSRANITVCVGGGIGTPRRAAEYLSGRWAQAYGFPLMPIDGILVGTA MMAR_3962|M.marinum_M SELRSRANITVCVGGGIGTPERAAEYLSGRWAQAYGFPLMPIDGILVGTA MUL_3818|M.ulcerans_Agy99 SELRSRANITVCVGGGIGTPERAAEYLSGRWAQAYGFPLMPIDGILVGTA MLBr_01191|M.leprae_Br4923 SELRSHANITVCVGGGIGTPEKAAEYLSGRWAQAYGFPLMPIDGILVGTA MAV_1650|M.avium_104 SELRSRPNITVCVGGGIGTPERAAEYLSGRWAEKYGFPLMPIDGILVGTA MAB_1512|M.abscessus_ATCC_1997 SELRSRSNITVCVGGGIGTPEQAAEYLSGRWALKFGFPLMPVDGILVGTA Mflv_2532|M.gilvum_PYR-GCK AMATLEATTSPAVKQMLVETTGTDTWVGAGKAINGMASGRSQLGADIHEI Mvan_4125|M.vanbaalenii_PYR-1 AMATLEATTSPAVKQLLVETTGTETWVGAGNAINGMASGRSQLGADIHEI TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 AMATLEATTSPQVKQLLVETKGTEAWVGAGKAANGMASGRSQLGADIHEI Rv2524c|M.tuberculosis_H37Rv AMATKESTTSPSVKRMLVDTQGTDQWISAGKAQGGMASSRSQLGADIHEI Mb2553c|M.bovis_AF2122/97 AMATKESTTSPSVKRMLVDTQGTDQWISAGKAQGGMASSRSQLGADIHEI MMAR_3962|M.marinum_M AMAALEATTSPSVKKMLVETQGTGEWIGAGKAQGGMASSRSQLGADIHEI MUL_3818|M.ulcerans_Agy99 AMAALEATTSPSVKKMLVETQGTGEWIGAGKAQGGMASSRSQLGADIHEI MLBr_01191|M.leprae_Br4923 AMATKEATTSPSVKRMLVETQGTDQWIGSGKAQGGMASSRSQLGADIHEI MAV_1650|M.avium_104 AMATLESTTSPSVKRMLVETQGTEHWIGAGKAVGGMASSRSQLGADIHEI MAB_1512|M.abscessus_ATCC_1997 AMATLEATTSPSVKQMLVQTQGTPEWVPAGKAQGGMASGRSQLGADIHEI Mflv_2532|M.gilvum_PYR-GCK DNTASRCGRLLDEVAGDADAVAERRDEIIAAMADTAKPYFGDVADMTYLQ Mvan_4125|M.vanbaalenii_PYR-1 DNTASRCGRLLDEVAGDADAVAERRDELIAAMANTAKPYFGDVGDMTYLQ TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 DNAASRCGRLLDEVAGDADAVAERRDEIIAAMAQTAKPYFGDVAEMTYLQ Rv2524c|M.tuberculosis_H37Rv DNSASRCGRLLDEVAGDAEAVAERRDEIIAAMAKTAKPYFGDVADMTYLQ Mb2553c|M.bovis_AF2122/97 DNSASRCGRLLDEVAGDAEAVAERRDEIIAAMAKTAKPYFGDVADMTYLQ MMAR_3962|M.marinum_M DNSASRCGQLLDEVAGDADAVAERRDEIIAAMAKTAKPYFGDIADMTYLQ MUL_3818|M.ulcerans_Agy99 DNSASRCGQLLDEVAGDADAVAERRDEIITAMAKTAKPYFGDIADMTYLQ MLBr_01191|M.leprae_Br4923 DNAASRCGRLLDEVAGDAEAVAERRDEIIAAMANTAKPYFGDVSEMTYLQ MAV_1650|M.avium_104 DNSASRCGRLLDEVAGDAEAVAERRDEIIAAMAKTAKPYFGDVGEMTYLQ MAB_1512|M.abscessus_ATCC_1997 DNAASRCGRLLDDVAGDADAVAKRRDEIIAAMELTAKQYFGDVAEMSYAQ Mflv_2532|M.gilvum_PYR-GCK WLQRYVELAIGDGDSTADTAAPGSPWLADTWRDRFEEMLTRAEARLNEKD Mvan_4125|M.vanbaalenii_PYR-1 WLQRYIELAIGDGDSTADTAAPGSPWLADTWRERFEEMLKRAEARLNEKD TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 WLRRYVELAIGDGNSTADTKRPDSPWLDITWRDRFEQMLKRAEARLHPQD Rv2524c|M.tuberculosis_H37Rv WLRRYVELAIGEGNSTADTASVGSPWLADTWRDRFEQMLQRAEARLHPQD Mb2553c|M.bovis_AF2122/97 WLRRYVELAIGEGNSTADTASVGSPWLADTWRDRFEQMLQRAEARLHPQD MMAR_3962|M.marinum_M WLQRYVELAIGEGNSTADTAAPGSPWLADTWRDRFQQMLQRAEARLHPQD MUL_3818|M.ulcerans_Agy99 WLQRYVELAIGEGNSTADTAAPGSPWLADTWRDRFQQMLQRAEARLHPQD MLBr_01191|M.leprae_Br4923 WLQRYVELTIGEGNSTADTASPGSPWLADTWRDRFQKMLQRAESRLHPSD MAV_1650|M.avium_104 WLQRYVELAIGDGDSTADTASPGSPWLADTWRDRFEQMLQRAEARLHAKD MAB_1512|M.abscessus_ATCC_1997 WLNRYVELSIGDGDSTADTAVAHSPWLDITWRDRFEQMLKRAEARLHPKD Mflv_2532|M.gilvum_PYR-GCK SGPIESLLAAD-----GKALLETPDVAIDALLTRYPDAETVKLHPADVPF Mvan_4125|M.vanbaalenii_PYR-1 SGPIESLFSDSGASSGGQALLDNPDAAIAALLARYPDAESVKLHPADVPF TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 FGPIETLFDADAD---GERLLEDPEAAITALLQRYPDAETVVLHPADVPF Rv2524c|M.tuberculosis_H37Rv FGPIQTLFT-------DAGLLDNPQQAIAALLARYPDAETVQLHPADVPF Mb2553c|M.bovis_AF2122/97 FGPIQTLFT-------DAGLLDNPQQAIAALLARYPDAETVQLHPADVPF MMAR_3962|M.marinum_M FGPIETAFA-------DPALLENPTQTIAALLARYPDAETVQLHPADVPF MUL_3818|M.ulcerans_Agy99 FGPIETAFA-------DPALLENPTQTIAALLARYPDAETVQLHPADVPF MLBr_01191|M.leprae_Br4923 FGLIKTIFT-------DPVLLEKPNQAIAALLKYYPDAETVQLHPADAPF MAV_1650|M.avium_104 FGPIETLFDGSTED--GARLLENPAEAIATLLAHYPDAESVQLHPADVPF MAB_1512|M.abscessus_ATCC_1997 FGPVETLFA-------DDTLLERPAEAIAALLQRYPDAESVKLHPADVPF Mflv_2532|M.gilvum_PYR-GCK FVTLCKKPGKPVNFVPVIDKDVRRWWRSDSLWQAHDARYTADQVCIIPGT Mvan_4125|M.vanbaalenii_PYR-1 FVTLCKKPGKPVNFVPVIDKDVRRWWRSDSLWQAHDARYSADQVCIIPGT TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 FVELCKTLGKPVNFVPVIDKDVRRWWRSDSLWQAHDARYEADQVCVIPGT Rv2524c|M.tuberculosis_H37Rv FVTLCKTLGKPVNFVPVIDQDVRRWWRSDSLWQAHDARYDADAVCIIPGT Mb2553c|M.bovis_AF2122/97 FVTLCKTLGKPVNFVPVIDQDVRRWWRSDSLWQAHDARYDADAVCIIPGT MMAR_3962|M.marinum_M FVTLCKTLGKPVNFVPVIDKDVRRWWRSDSLWQAHDARYDADQVCIIPGP MUL_3818|M.ulcerans_Agy99 FVTLCKTLGKPVNFVPVIDKDVRRWWRSDSLWQAHDARYDADQVCIIPGP MLBr_01191|M.leprae_Br4923 FVMLCQMLGKPVNFVPVIDKDVRRWWRSDSLWQAHDARYDADQVCIIPGI MAV_1650|M.avium_104 FVTLCKTPGKPVNFVPVIDKDVRRWWRSDSLWQAHDARYDADQVCIIPGT MAB_1512|M.abscessus_ATCC_1997 FVALCKTLGKPVNFVPVIDKDVRRWWRSDSLWQAHDARYTAEQVCIIPGT Mflv_2532|M.gilvum_PYR-GCK QAVAGITRVDEPVGELLDRFEQEIVDRVLAAGAEPTPVVSRRQARADVSG Mvan_4125|M.vanbaalenii_PYR-1 QAVAGITRVDEPVGELLDRFEQEIVDRVLAAGVQPVPVVSRRQARADVSG TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 AAVAGITRVDEPVGELLDRFEQAAVDEVLGAGAEPVEVLSRRQARRDASG Rv2524c|M.tuberculosis_H37Rv ASVAGITRMDEPVGELLDRFEQAAIDEVLGAGVEPKDVASRRLGRADVAG Mb2553c|M.bovis_AF2122/97 ASVAGITRMDEPVGELLDRFEQAAIDEVLGAGVEPKDVASRRLGRADVAG MMAR_3962|M.marinum_M AAVAGITRMDEPVGELLDRFERAAIDEVLGSDGDAKAVTSRRLGRPDVTG MUL_3818|M.ulcerans_Agy99 AAVAGITRMDEPVGELLDRFERAAIDEVLGSDGDAKAVTSRRLGRPDVTG MLBr_01191|M.leprae_Br4923 AAVAGITQMDEPVGELLDRFEQAAIDEVLAGGAEPVVVMSRRLGRADVAG MAV_1650|M.avium_104 AAVAGITRMDEPVGELLDRFEQAAIDEALAAGVQPAAVTSRRTGRADVTG MAB_1512|M.abscessus_ATCC_1997 AAVAGITRVDEPVGELLNRFEQAAVDEVVAAGVEPLPVRSRLRRRWDVEG Mflv_2532|M.gilvum_PYR-GCK PLAVVLDSPDVLWAGRTAINPVHRIGAPSEWQVNDVPGKPSATHPNTGAR Mvan_4125|M.vanbaalenii_PYR-1 PLAVVLDSPDVLWAGRTAINPVHRIGAPGEWQVNDVPGKPSATHPNTGAR TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 PLAVVLDAPDVLWAGRMSVNPVHRIAAPTEWQVREGSDNRSASHPSTGAR Rv2524c|M.tuberculosis_H37Rv PLAVVLDAPDVRWAGRTVTNPVHRIADPAEWQVHDGPENPRATHSSTGAR Mb2553c|M.bovis_AF2122/97 PLAVVLDAPDVRWAGRTVTNPVHRIADPAEWQVHDGPENPRATHSSTGAR MMAR_3962|M.marinum_M PLAVVLDAPDVLWAGRTATNPVHRIADPSEWQVHDGPESPRATHTSTGAR MUL_3818|M.ulcerans_Agy99 PLAVVLDAPDVLWAGRTATNPVHRIADPSEWQVHDGPESPRATHTSTGAR MLBr_01191|M.leprae_Br4923 PLAVVLDAPDVLWAGRIATNPVHRIADPNEWQVNG---NLSATHSSTGAQ MAV_1650|M.avium_104 PLAVVLDAPDVQWAGRTAINPVHRIAEPGDWLVHDGPDSRRATHSSTGAR MAB_1512|M.abscessus_ATCC_1997 PLATVLDAPDVLWSGRIAVNPVHRIAPDGAWQVFEDR---TASHPSTGAR Mflv_2532|M.gilvum_PYR-GCK LELAGDGS----------VTLSVPLSDIWIDIRFTLPAATVDGGAPIVTV Mvan_4125|M.vanbaalenii_PYR-1 LEQATDDSGHV------SVTLSVPLSDIWIDIRFTLPAATVDGGAPIVTV TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 LEVADDQH----------VVLSVPLSGTWIEIRFTLTDVVRSGGAPIVEV Rv2524c|M.tuberculosis_H37Rv LQTHGDD-----------VALSVPVSGTWVDIRFTLPANTVDGGTPVIAT Mb2553c|M.bovis_AF2122/97 LQTHGDD-----------VALSVPVSGTWVDIRFTLPANTVDGGTPVIAT MMAR_3962|M.marinum_M LQIQGSD-----------VVLSVPVSATWIDIRFTLPANTVDGGIPVVST MUL_3818|M.ulcerans_Agy99 LQVQGSD-----------VVLSVPVSATWIDIRFTLPANTVDGGIPVVST MLBr_01191|M.leprae_Br4923 LQVKSEDQ---------QVVLSVPVSNGWIDIPFTLPTNTVDGGALLVST MAV_1650|M.avium_104 LQVEGDR-----------VVLSVPVSGTWVEIPFTLPPNTIDGGTPVVST MAB_1512|M.abscessus_ATCC_1997 LEVIGAAGSATSSEADGIVRLSVPLSGTWVDIDLTLPTTTRDGGTPVVTT Mflv_2532|M.gilvum_PYR-GCK EDASKAMRSVLAIAAGVDGPDSLPAVENNTATVTVEWDPQKVADHTGVTA Mvan_4125|M.vanbaalenii_PYR-1 EDAAKAMRSVLAIAAGVEGPESLPPVQGDTAAVTVEWDPEKVADHTGVTA TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 DDAATAMRAVLAIAAGVEGPENLPKVVDNTATVTVDWDPERVADHTGVTA Rv2524c|M.tuberculosis_H37Rv EDATSAMRTVLAIAAGVDSPEFLPAVANGTATLTVDWHPERVADHTGVTA Mb2553c|M.bovis_AF2122/97 EDATSAMRTVLAIAAGVDSPEFLPAVANGTATLTVDWHPERVADHTGVTA MMAR_3962|M.marinum_M DDATTAMRSVLAIAAGVDGPESLPPVTDGTATVTVDWDPEKVADHTGVTA MUL_3818|M.ulcerans_Agy99 DDATTAMRSVLAIAAGVDGPESLPSVTDGTATVTVDWDPEKVADHTGVTA MLBr_01191|M.leprae_Br4923 EDATSAMRAVLAIVAGVDGPELLSPVKDGTAIVTVDWNPERVADHTGVTA MAV_1650|M.avium_104 DDAATAMRAVLAIAAGVDGPEFLPKVVDGAATVTVDWDPERVADHTGVTA MAB_1512|M.abscessus_ATCC_1997 EAASAAMRTVLAVAGGADTPEGLPPVENGIARVVAHWDPERVADHTGVTA Mflv_2532|M.gilvum_PYR-GCK TFGAPLAPGLTLVPDALVGLCWPAVFSAIGSAVTDDGFPVVEGLLSLVHL Mvan_4125|M.vanbaalenii_PYR-1 TFGAPLAPGLTLVPDALVGLCWPAVFSAIGSALTEDGFPVVEGLLSLVHL TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 TFGAPLAPTLTVVPDALVGRCWPAVFAAIGSAATEAGFPVIEGLLSLVHL Rv2524c|M.tuberculosis_H37Rv TFGEPLAPSLTNVPDALVGPCWPAVFAAIGSAVTDTGEPVVEGLLSLVHL Mb2553c|M.bovis_AF2122/97 TFGEPLAPSLTNVPDALVGPCWPAVFAAIGSAVTDTGEPVVEGLLSLVHL MMAR_3962|M.marinum_M TFGEPLAPSLTTVPDALVGQCWPAVFAAIGSAVTDSGVPVVEGLLSLVHL MUL_3818|M.ulcerans_Agy99 TFGEPLAPSLTTVPDALVGQCWPAVFAAIGSAVTDSGVPVVEGLLSLVHL MLBr_01191|M.leprae_Br4923 TFREPLAPSLATVPDALVGACWPAVFSAIGSAVTEAGVLVVEGLLNLLHL MAV_1650|M.avium_104 TFGEPLAPSLTTVPDALVGLCWPAVFAAIGAAATDTGVPVVEGLLSLVHL MAB_1512|M.abscessus_ATCC_1997 VLPAPLAPGSSVVPDALVGLCWPAVFAAIGDAKTTDGTGVIEGLLSLVHL Mflv_2532|M.gilvum_PYR-GCK DHAAHLLAALPSSTAELTVTATASAATDTEVGRVVPVEVTIA---DSEGT Mvan_4125|M.vanbaalenii_PYR-1 DHAAHLLTSMPSSKSELTVTATASAATDTEVGRVVPVDVTIA---DSEGT TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 DHAARLLAELPKEPAEFTVTAKASAATDTEVGRVVPVSVEVRN--AADGA Rv2524c|M.tuberculosis_H37Rv DHAARVVGQLPTVPAQLTVTATAANATDTDMGRVVPVSVVV---TGADGA Mb2553c|M.bovis_AF2122/97 DHAARVVGQLPTVPAQLTVTATAANATDTDMGRVVPVSVVV---TGADGA MMAR_3962|M.marinum_M DHAARVVGDLPKIPAQLSVTATTSSATDTDMGRVVPVSVTV---AGPDGA MUL_3818|M.ulcerans_Agy99 DHAARVVGDLPKIPAQLTVTATASNATDTDMGRAVPVSVTV---AGPDGA MLBr_01191|M.leprae_Br4923 DHAVCVVGKLPTVPAQLTVTATVSLAIDTDMGRVVPVSVTIRDTTGADGA MAV_1650|M.avium_104 DHAAHMVGKLPTTLAQLTVTATASAAADTDMGRVVPVSVTI---ADAGGQ MAB_1512|M.abscessus_ATCC_1997 DHAAHLMADLPAESAELTVTATASAAIDTEVGRVVPVDVTVA---AADGA Mflv_2532|M.gilvum_PYR-GCK VLATLSERFAIRGRTGAVELTDPPRAGGAITDNATDTPRRRRRDVIVTAP Mvan_4125|M.vanbaalenii_PYR-1 VLATLSERFAIRGRTGAAELADPPRAGGAITDNATDTPRRRRRDVVVNAP TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 LLATLEERFAIRGRTGAAELTDPVRAGGAISDNATDTPRRRRRDVTVGAP Rv2524c|M.tuberculosis_H37Rv VIATLEERFAILGRTGSAELADPARAGGAVSANATDTPRRRRRDVTITAP Mb2553c|M.bovis_AF2122/97 VIATLEERFAILGRTGSAELADPARAGGAVSANATDTPRRRRRDVTITAP MMAR_3962|M.marinum_M TIATLEERFAILGRTGTAELSDPVRAGGTVSENATDTPRRRRRDVTLTAP MUL_3818|M.ulcerans_Agy99 TIATLEERFAILGRTGTAELSDPVRAGGTVSENATDTPRRRRRDVTLTAP MLBr_01191|M.leprae_Br4923 VLATLEERFVILGRTGTAELTGPVRAGGAISENATDTPRRRRRDVTLTAP MAV_1650|M.avium_104 VIATLDERFAILGRTGPAELTDPARAGGAVSENATDTPRRRRRDVTITAP MAB_1512|M.abscessus_ATCC_1997 VLATLQERFAILGRNGAAELTDPVRAGGALSEHEVDTTRRRRRDVKIFAP Mflv_2532|M.gilvum_PYR-GCK VDMSAFAVVSGDHNPIHTDRAAALLAGLKMPIVHGMWLSAAAQHAVTATD Mvan_4125|M.vanbaalenii_PYR-1 VDMSAFAVVSGDHNPIHTDRAAALLAGLKTPIVHGMWLSAAAQHAVTATD TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 VDMRPFAVVSGDHNPIHTDRAAALLAGLEGPIVHGMWLSAAAQHVVTATD Rv2524c|M.tuberculosis_H37Rv VDMRPFAVVSGDHNPIHTDRAAALLAGLESPIVHGMWLSAAAQHAVTATD Mb2553c|M.bovis_AF2122/97 VDMRPFAVVSGDHNPIHTDRAAALLAGLESPIVHGMWLSAAAQHAVTATD MMAR_3962|M.marinum_M VDMRPFAVVSGDHNPIHTDRSAALLAGLESPIVHGMWLSAAAQHTVTATD MUL_3818|M.ulcerans_Agy99 VDMRPFAVVSGDHNPVHTDRSAALLAGLESPIVHGMWLSAAAQHTVTATD MLBr_01191|M.leprae_Br4923 IDMRPFAVVSGDHNPIHTDRTAALLAGLESPIVHGMWLSAAAQHVVMATD MAV_1650|M.avium_104 VDMRPFAVVSGDHNPIHTDRAAALLAGLETPIVHGMWLSAAAQHAVTATD MAB_1512|M.abscessus_ATCC_1997 TDMSAFAVVSGDHNPIHTDKSAALLAGLGSPIVHGMWLSAAAQHVVTSAD Mflv_2532|M.gilvum_PYR-GCK GRATPPARLVGWTSRFLGMVLPGDEIEFRVDRVGIDRGAEIVEVAAKVGG Mvan_4125|M.vanbaalenii_PYR-1 GRATPPARLVGWTSRFLGMVLPGDEIEFRVDRVGIDRGAEIIEVAAKVGG TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 GKPVPPAKLIGWTARFLGMVKPGDQVDFRVDRVGIDVGAEVLEVSARIGS Rv2524c|M.tuberculosis_H37Rv GQARPPARLVGWTARFLGMVRPGDEVDFRVERVGIDQGAEIVDVAARVGS Mb2553c|M.bovis_AF2122/97 GQARPPARLVGWTARFLGMVRPGDEVDFRVERVGIDQGAEIVDVAARVGS MMAR_3962|M.marinum_M GKARPPARLVGWTARFLGMVRPGDDVDFRVERVGIDQGAEVLEVSARIGS MUL_3818|M.ulcerans_Agy99 GKARPPARLVGWTARFLGMVRPGDDVDFRVERVGIDQGAEVLEVSARIGS MLBr_01191|M.leprae_Br4923 GQARPAARLIGWTARFLGMAHPGDKVDFRVDRIGIDQGAEILEVSARISS MAV_1650|M.avium_104 GQARPPARLIGWTARFLGMVRPGDEVAFRVDRVGIDQGAEVLEVAARVGS MAB_1512|M.abscessus_ATCC_1997 ASSTPPRTLIGWTSRFLGMVQPGDEVDIRVDRVGIDSGAEVVEVQAKVGA Mflv_2532|M.gilvum_PYR-GCK ELVMAATAQLAAPKTVYAFPGQGIQSKGMGMDVRARSKAARKVWDTADKF Mvan_4125|M.vanbaalenii_PYR-1 ELVMSATAQLAAPKTVYAFPGQGIQSKGMGMDVRARSKAARAVWDTADKF TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 ELVMAATARLAAPKTVYAFPGQGIQHKGMGMEVRARSKAARKVWDSADKF Rv2524c|M.tuberculosis_H37Rv DLVMSASARLAAPKTVYAFPGQGIQHKGMGMEVRARSKAARKVWDTADKF Mb2553c|M.bovis_AF2122/97 DLVMSASARLAAPKTVYAFPGQGIQHKGMGMEVRARSKAARKVWDTADKF MMAR_3962|M.marinum_M DLVMSASARLAAPKTVYAFPGQGIQHKGMGMEVRARSKAARKVWDTADRF MUL_3818|M.ulcerans_Agy99 DLVMSASARLAAPKTVYAFPGQGIQHKGMGMEVRARSKAARKVWDIADRF MLBr_01191|M.leprae_Br4923 GLVMSATARLAAPKTVYAFPGQGIQHKGMGMDVRARSKAARRVWDDADKF MAV_1650|M.avium_104 DLVMSATARLAAPRTVYAFPGQGIQHKGMGMDVRARSKAARKVWDKADKF MAB_1512|M.abscessus_ATCC_1997 DLVMSATARLAAPKTVYAFPGQGIQHKGMGMDVRSRSKAARKVWDKADKF Mflv_2532|M.gilvum_PYR-GCK TRETLGFSVLHVVRDNPTSLIASGVHYHHPEGVLYLTQFTQVAMATVAAA Mvan_4125|M.vanbaalenii_PYR-1 TRETLGFSVLHVVRDNPTSLIASGVHYHHPEGVLYLTQFTQVAMATVAAA TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 TRETLGFSVLHVVRDNPTSLIASGVHYHHPDGVLFLTQFTQVAMATVAAA Rv2524c|M.tuberculosis_H37Rv TRDTLGFSVLHVVRDNPTSIIASGVHYHHPDGVLYLTQFTQVAMATVAAA Mb2553c|M.bovis_AF2122/97 TRDTLGFSVLHVVRDNPTSIIASGVHYHHPDGVLYLTQFTQVAMATVAAA MMAR_3962|M.marinum_M TRDTLGFSVLHVVRDNPTSLIASGVHYHHPDGVLYLTQFTQVAMATVAAA MUL_3818|M.ulcerans_Agy99 TRDTLGFSVLHVVRDNPTSLIASGVHYHHPDGVLYLTQFTQVAMATVAAA MLBr_01191|M.leprae_Br4923 TRSGLGFSVLHVVRDNPTNITANGVHYHHPDGVLYLTQFTQVAMATVAVA MAV_1650|M.avium_104 TRDTLGFSVLHVVRDNPTSIIASGVHYNHPEGVLYLTQFTQVAMATVAAA MAB_1512|M.abscessus_ATCC_1997 TRDRLGFSVLHVVKDNPTSLIAGGVHYQHPEGVLYLTQFTQVAMATVAAA Mflv_2532|M.gilvum_PYR-GCK QVAEMREQGAFVEGAIACGHSVGEYTALACVSGVYPLEALLEVVFHRGSK Mvan_4125|M.vanbaalenii_PYR-1 QVAEMREQGAFVEGAIACGHSVGEYTALACVSGVYELPALLEVVFHRGSK TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 QVAEMREQGAFVEGAIACGHSVGEYTALACVSGVYELEALLEVVFHRGSK Rv2524c|M.tuberculosis_H37Rv QVAEMREQGAFVEGAIACGHSVGEYTALACVTGIYQLEALLEMVFHRGSK Mb2553c|M.bovis_AF2122/97 QVAEMREQGAFVEGAIACGHSVGEYTALACVTGIYQLEALLEMVFHRGSK MMAR_3962|M.marinum_M QVAEMREQGAFVEGAIACGHSVGEYTALACVTGIYELEALLEMVFHRGSK MUL_3818|M.ulcerans_Agy99 QVAEMREQGAFVEGAIACGHSVGEYTALACVTGIYELEALLEMVFHRGSK MLBr_01191|M.leprae_Br4923 QVAEMREQGAFVEGAIACGHSVGEYTALACVMGVYELEALLETVFHRGSK MAV_1650|M.avium_104 QVAEMREQGAFVEDAIACGHSVGEYTALACVTGIYELEALLETVFHRGSK MAB_1512|M.abscessus_ATCC_1997 QIAEMKESGSFVEDAITCGHSVGEYTALATVSGVIELEGLLEVVFHRGSA Mflv_2532|M.gilvum_PYR-GCK MHDIVPRDAQGRSNYRLAAIRPSQIDLDDDDVTAFVAEVSERTGEFLEIV Mvan_4125|M.vanbaalenii_PYR-1 MHDIVPRDAQGRSNYRLAAIRPSQIDLDDADVKDFVAEISDRTGEFLEIV TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 MHDIVPRDELGRSNYRLAAIRPSQIDLDDADVKDFVAEISERTGEFLEIV Rv2524c|M.tuberculosis_H37Rv MHDIVPRDELGRSNYRLAAIRPSQIDLDDADVPAFVAGIAESTGEFLEIV Mb2553c|M.bovis_AF2122/97 MHDIVPRDELGRSNYRLAAIRPSQIDLDDADVPAFVAGIAESTGEFLEIV MMAR_3962|M.marinum_M MHDIVPRDELGRSNYRLAAIRPSQIDLDDNDVPAFVAGIAESTGEFLEIV MUL_3818|M.ulcerans_Agy99 MHDIVPRDELGRSNYRLAAIRPSQIDLDDNDVPAFVAGIAESTGEFLEIV MLBr_01191|M.leprae_Br4923 MHDIVLRDELGRSNYRLAAIRPSQIGLPDDEVPAFVRGIAESTGEFLEIV MAV_1650|M.avium_104 MHDIVPRDELGRSNYRLAAIRPSQIDLPDDEVPAFVAGIAERTGEFLEIV MAB_1512|M.abscessus_ATCC_1997 MHDIVPRDELGRSNYRLAAIRPSQIGLDDADVDAFVAEIAERSGEFLQIV Mflv_2532|M.gilvum_PYR-GCK NFNLRGAQYAIAGTVAGLEALEEEVERRREISGGKRSFILVPGIDVPFHS Mvan_4125|M.vanbaalenii_PYR-1 NYNLRGSQYAIAGTVAGLEALEAEVERRRELSGGKRSFILVPGIDVPFHS TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 NFNLRGSQYAIAGTVAGLEALEEEIERRRQITGGKRSFILVPGIDVPFHS Rv2524c|M.tuberculosis_H37Rv NFNLRGSQYAIAGTVRGLEALEAEVERRRELTGGRRSFILVPGIDVPFHS Mb2553c|M.bovis_AF2122/97 NFNLRGSQYAIAGTVRGLEALEAEVERRRELTGGRRSFILVPGIDVPFHS MMAR_3962|M.marinum_M NFNLRGSQYAIAGTVRGLEALEAEVERRRELSGGRRSFILVPGIDVPFHS MUL_3818|M.ulcerans_Agy99 NFNLRGSQYAIAATVRGLEALEAEVERRRELSGGRRSFILVPGIDVPFHS MLBr_01191|M.leprae_Br4923 NFNLRGSQYAIAGTVHGLEALEAEVERRRELTGGRRSFILVPGIDVPFHS MAV_1650|M.avium_104 NFNLRGSQYAIAGTVRGLEALEEEVERRREITGGKRSFILVPGIDVPFHS MAB_1512|M.abscessus_ATCC_1997 NFNLRGSQYAIAGTVRGLELLEAEVERRREEFGGRRSFILVPGIDVPFHS Mflv_2532|M.gilvum_PYR-GCK SVLRVGVADFRRALERVMPTDADPELLIGRYIPNLVPRPFTLDRDFIEEI Mvan_4125|M.vanbaalenii_PYR-1 SVLRVGVADFRRALERVMPNPNDPNLLVGRYIPNLVPRPFTLDRDFIQEI TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 SVLRVGVADFRRSLERVMPRDKDPELIIGRYIPNLVPRPFTLDRDFIQEI Rv2524c|M.tuberculosis_H37Rv RVLRVGVAEFRRSLDRVMPRDADPDLIIGRYIPNLVPRLFTLDRDFIQEI Mb2553c|M.bovis_AF2122/97 RVLRVGVAEFRRSLDRVMPRDADPDLIIGRYIPNLVPRLFTLDRDFIQEI MMAR_3962|M.marinum_M RVLRVGVAEFRRSLDRVMPRDADPDLIIGRYIPNLVPRLFNLDRDFIQEI MUL_3818|M.ulcerans_Agy99 RVLRVGVAEFRRSLDRVMPRDADPDLIIGRYIPNLVPRLFNLDRDFIQEI MLBr_01191|M.leprae_Br4923 RVLRVGVAEFRRSLDRVLPQDQDPDWIIGRYIPNLVPRPFTLARDFIQEI MAV_1650|M.avium_104 RVLRVGVAEFRRSLDRVMPRDKDPDIIIGRYIPNLVPRPFTLDRDFIQEI MAB_1512|M.abscessus_ATCC_1997 KVLRVGVAEFRRSLERVLPMDGDPNLIIGKYIPNLVPKPFTLDREFIQEI Mflv_2532|M.gilvum_PYR-GCK RDLVPAEPLDEVLADYDTWRNERPRELMRKIVIELLAWQFASPVRWIETQ Mvan_4125|M.vanbaalenii_PYR-1 RDLVPAEPLDEILADYDTWRNERPSELCRKIVIELLAWQFASPVRWIETQ TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 RDLVPAEPLDEVLADYDTWRNEKPKELCRKVVIELLAWQFASPVRWIETQ Rv2524c|M.tuberculosis_H37Rv RDLVPAEPLDEILADYDTWLRERPREMARTVFIELLAWQFASPVRWIETQ Mb2553c|M.bovis_AF2122/97 RDLVPAEPLDEILADYDTWLRERPREMARTVFIELLAWQFASPVRWIETQ MMAR_3962|M.marinum_M RDLVPAEPLDEILADYDTWIRERPRELARTVFIELLAWQFASPVRWIETQ MUL_3818|M.ulcerans_Agy99 RDLVPAEPLDEILADYDTWIRERPRELARTVFIELLAWQFASPVRWIETQ MLBr_01191|M.leprae_Br4923 RDLVPAEPLDDILADYDTWRRERPSEMARRVLIELLAWQFASPVRWIETQ MAV_1650|M.avium_104 RDLVPAEPLDPILADYDTWLAERRIEMARTVLIELLAWQFASPVRWIETQ MAB_1512|M.abscessus_ATCC_1997 RDLVPAEPLDEVLANYDTWRNEKPVLLCRKVLIELLAWQFASPVRWIETQ Mflv_2532|M.gilvum_PYR-GCK DLLFIEEAAGGLGVERFVEIGVKNAPTVAGLATNTLKLPEYSHNTTEVLN Mvan_4125|M.vanbaalenii_PYR-1 DLLFIEEAAGGLGVERFVEIGVKNAPTVAGLAANTLKLPEYSHNTTEVLN TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 DLLFIEEAAGGLGVERFVEIGVKSAPTVAGLATNTLKLPEYSHSTVEVLN Rv2524c|M.tuberculosis_H37Rv DLLFIEEAAGGLGVERFVEIGVKSSPTVAGLATNTLKLPEYAHSTVEVLN Mb2553c|M.bovis_AF2122/97 DLLFIEEAAGGLGVERFVEIGVKSSPTVAGLATNTLKLPEYAHSTVEVLN MMAR_3962|M.marinum_M DLLFIEEAAGGLGVERFVEIGVKTSPTVAGLATNTLKLPEYAHSTVEVLN MUL_3818|M.ulcerans_Agy99 DLLFIEEAAGGLGVERFVEIGVKTSPTVAGLATNTLKLPEYAHSTVEVLN MLBr_01191|M.leprae_Br4923 DLLFTEEAAGGLGVERFVEIGVKSAPTVAGLATDTLKLPEYSHNTVEVLN MAV_1650|M.avium_104 DLLFTEEAAGGLGVERFVEIGVKSAPTVAGLATNTLKLPEYAHSTVEVLN MAB_1512|M.abscessus_ATCC_1997 DLLFTEEAAGGLGVERFVEVGVKSAPTVTGLANNTLKLPEYSHSSIEVLN Mflv_2532|M.gilvum_PYR-GCK AERDAAVLFATDTDPEPDFEDAAPEAP--AAAAPAEAAPAEAAPAAPAPA Mvan_4125|M.vanbaalenii_PYR-1 AERDAAVLFATDTDPEPDPEDDVADATPAAETAPAEAVPAEAAPAAPAPA TH_1319|M.thermoresistible__bu -------------------------------------------------- MSMEG_4757|M.smegmatis_MC2_155 SERDAAVLFATDTDPEPEPEADEPTADAPAEAAPAAAA----APAPVAAP Rv2524c|M.tuberculosis_H37Rv AERDAAVLFATDTDPEPEPEEDE----PVAESPAPDVVSEAAP-VAPAAS Mb2553c|M.bovis_AF2122/97 AERDAAVLFATDTDPEPEPEEDE----PVAESPAPDVVSEAAP-VAPAAS MMAR_3962|M.marinum_M AERDAAVLFATDTDPEPEPEPEA----EEPAAEAGDAAAAPAPAAAPAAP MUL_3818|M.ulcerans_Agy99 AERDAAVLFATDTDPEPEPEPEA----EEPAAEAGDAAAAAAPAAAPAAP MLBr_01191|M.leprae_Br4923 VERDAAVLFATDTDPELEPEPEN----VSDASAALPAESALALGTVAPAP MAV_1650|M.avium_104 AERDAAVLFATDTDPEPEPEADE----ASDSAVPASSDGAPMSDVAPAPA MAB_1512|M.abscessus_ATCC_1997 VERDHAVLFGTDSDPEPEPEIEEP-----VESTAAASGSVEAAPAPAAAP Mflv_2532|M.gilvum_PYR-GCK AAPSGGPRPEDLTFDAADATMALIALSAKIRIDQIEALDSIESITDGASS Mvan_4125|M.vanbaalenii_PYR-1 AAPSGGPRPDDLAFDAADATMALIALSAKIRIDQIEALDSIESITDGASS TH_1319|M.thermoresistible__bu --------------------MALIALSAKMRLDQIEPLDSIESITDGASS MSMEG_4757|M.smegmatis_MC2_155 AAPSGGPRPDDITFDAADATVALIALSAKMRIDQIEALDSIESITDGASS Rv2524c|M.tuberculosis_H37Rv SA---GPRPDDLVFDAADATLALIALSAKMRIDQIEELDSIESITDGASS Mb2553c|M.bovis_AF2122/97 SA---GPRPDDLVFDAADATLALIALSAKMRIDQIEELDSIESITDGASS MMAR_3962|M.marinum_M SG---GPRPDDIGFDAADATLALIALSAKMRLDQIEELDSIESITDGASS MUL_3818|M.ulcerans_Agy99 SG---GPRPDDIGFDAADATLALIALSAKMRLDQIEQLDSIESITDGASS MLBr_01191|M.leprae_Br4923 VVPS-GPRPEDISFGAADATLALIALSAKMRLDQIEEMDSIESITDGASS MAV_1650|M.avium_104 AAPSGAPRPEDIPFDAADATLALIALSAKMRIDQIEELDSIESITDGASS MAB_1512|M.abscessus_ATCC_1997 AAPSGGPRPDDLGFDASDATLALIALSTKMRIDQIEPVDSIESLTDGASS :******:*:*:**** :*****:****** Mflv_2532|M.gilvum_PYR-GCK RRNQMLVDLGSELNLGAIDGAAEADLAGLKGQVTKLARTYKPFGPVLSDA Mvan_4125|M.vanbaalenii_PYR-1 RRNQMLVDLGSELNLGAIDGAAEADLAGLKGQVTKLARTYKPFGPVLSDA TH_1319|M.thermoresistible__bu RRNQLLVDLGSELNLGAIDGAAEADLGSLKGQVTKLARTYKPFGPVLSDA MSMEG_4757|M.smegmatis_MC2_155 RRNQLLVDLGSELNLGAIDGAAEADLGALKGQVTKLARTYKPFGPVLSDA Rv2524c|M.tuberculosis_H37Rv RRNQLLVDLGSELNLGAIDGAAESDLAGLRSQVTKLARTYKPYGPVLSDA Mb2553c|M.bovis_AF2122/97 RRNQLLVDLGSELNLGAIDGAAESDLAGLRSQVTKLARTYKPYGPVLSDA MMAR_3962|M.marinum_M RRNQLLVDLGSELNLGAIDGAAEADLAGLRSQVTKLARTYKPYGPVLSDA MUL_3818|M.ulcerans_Agy99 RRNQLLVDLGSELNLGAIDGAAEADLAGLRSKVTKLARTYKPYGPVLSDA MLBr_01191|M.leprae_Br4923 RRNQLLVDLGSELSLGAIDGVAEADLAGLRSQVTKLARTYKPYGPVLSEL MAV_1650|M.avium_104 RRNQLLVDLGSELNLGAIDGAAEADLAGLRTQVTKLARTYKPYGPVLSDA MAB_1512|M.abscessus_ATCC_1997 RRNQLLVDLGSELNLSAIDGAAEADLSGLRVQVTKLARTYKPFGPVLSDS ****:********.*.****.**:**..*: :**********:*****: Mflv_2532|M.gilvum_PYR-GCK INDQLRTVLGPSGKRPAYIVERVKKTWELGDGWGKHVTVEVALGTREGTS Mvan_4125|M.vanbaalenii_PYR-1 INDQLRTVFGPSGKRPAYIAERVKKTWELGDGWAKHATVEVALGTREGSS TH_1319|M.thermoresistible__bu INDQLRTVLGPSGKRPAYIAERVAKTWELGEGWAKHVTVEVALGTREGSS MSMEG_4757|M.smegmatis_MC2_155 INDQLRTVLGPSGKRPAYITERVTKTWELGPGWAKHVTVEFALGTREGSS Rv2524c|M.tuberculosis_H37Rv INDQLRTVLGPSGKRPGAIAERVKKTWELGEGWAKHVTVEVALGTREGSS Mb2553c|M.bovis_AF2122/97 INDQLRTVLGPSGKRPGAIAERVKKTWELGEGWAKHVTVEVALGTREGSS MMAR_3962|M.marinum_M INDQLRTVLGPSGKRPGAIAERVKKTWELGDGWAKHVTVEVALGTREGSS MUL_3818|M.ulcerans_Agy99 INDQLRTVLGPSGKRPGAIAERVKKTWELGDGWAKHVTVEVALGTREGSS MLBr_01191|M.leprae_Br4923 INDQLRSALGPSGKRPGVIAERVKKIWELGDGWVKHVTVEIALGTREGTS MAV_1650|M.avium_104 INDQLRTVLGPSGKRPGAIAERVKKTWELGEGWAKHVTVEVALGTREGTS MAB_1512|M.abscessus_ATCC_1997 INDQLKTVFGPSGKRPTAIAERVTKTWELGPGWVKHVTVELALGTREGTS *****::.:******* *.*** * **** ** **.***.*******:* Mflv_2532|M.gilvum_PYR-GCK VRGGALGGLHDGALADAAAVDKAIDAAVAAVGARRGVPVSLPSAAGGGGG Mvan_4125|M.vanbaalenii_PYR-1 VRGGALGGLHDGALADAAAVDKAIDAAVAAIGARKGVSVSLPSAAGGGGG TH_1319|M.thermoresistible__bu VRGGDLGGLHDGALADAAAVDKVIDAAVGAVAARHGVAVSLPSSGGAGGG MSMEG_4757|M.smegmatis_MC2_155 VRGGDLGGLHAGALASAADVDKVIDGAVAAVAARRGISVSLPSAGGASGG Rv2524c|M.tuberculosis_H37Rv VRGGAMGHLHEGALADAASVDKVIDAAVASVAARQGVSVALPSAGSGGG- Mb2553c|M.bovis_AF2122/97 VRGGAMGHLHEGALADAASVDKVIDAAVASVAARQGVSVALPSAGSGGG- MMAR_3962|M.marinum_M VRGGALGNLHEGALADAASVDKVVDAAVASVAARRGVAVALPSAGGGGG- MUL_3818|M.ulcerans_Agy99 VRGGALGNLHEGALADAASVDKVVDAAVASVAARRGVAVALPSAGGGGG- MLBr_01191|M.leprae_Br4923 VRGGPLGNLNEGALADVDSVDKAVDAAVASVAARHGVVVALPSAGSGGS- MAV_1650|M.avium_104 VRGGALGHLHEGALADAAAVDKAIDAAVAAVAARRGITVALPSAGGGGAG MAB_1512|M.abscessus_ATCC_1997 VRGGDLGGLAPSTLADGNAVDTAIDAAVAAVAGRHGVGVTLPSAGGGGG- **** :* * .:**. **..:*.**.::..*:*: *:***:..... Mflv_2532|M.gilvum_PYR-GCK GVVDSAALGEFAEQVTGRNGVLASAARLILDQLGHSQVA--SAPESTADA Mvan_4125|M.vanbaalenii_PYR-1 -VVDSAALGEFAEQVTGPDGVLASAARTILDQLGLGNQF--VTPDASADA TH_1319|M.thermoresistible__bu -MVDSAALGEFAEQVTGRDGVLASAARLVLNQLGFDDTV--SVPEQATDS MSMEG_4757|M.smegmatis_MC2_155 -VVDSAALGEFAEKVTGPDGVLASAARLVLNQLGLSDVV--TTPEAATDA Rv2524c|M.tuberculosis_H37Rv ATIDAAALSEFTDQITGREGVLASAARLVLGQLGLDDPV--NALPAAPDS Mb2553c|M.bovis_AF2122/97 ATIDAAALSEFTDQITGREGVLASAARLVLGQLGLDDPV--NALPAAPDS MMAR_3962|M.marinum_M ATVDAAALAEFTDQITGRDGVLASAARLVLGQLGLDAPA--TALPAATDA MUL_3818|M.ulcerans_Agy99 ATVDAAALAEFTDQITGRDGVLASAARLVLGQLGLDAPA--TALPAATDA MLBr_01191|M.leprae_Br4923 ATVDVAALSEFTDQITGHDGVLASAARLVLGQLGLDGPV--TAAPATTDT MAV_1650|M.avium_104 ATIDAVALGEFTEQITGRDGVLASAARLVLNQLGLDEPAGAAAASAATDA MAB_1512|M.abscessus_ATCC_1997 ATVDAAALSEFTDQITGRDGVLASAARLVLDQLGLSAPV--AVPDGATDT :* .**.**::::** :******** :*.*** . . :.*: Mflv_2532|M.gilvum_PYR-GCK ELIDLVTAELGSDWPRLVAPVFDSRKAVVLDDRWASAREDLVKIWLMDED Mvan_4125|M.vanbaalenii_PYR-1 ELIDLVTAELGSDWPRLVAPVFDGRKAVVLDDRWASAREDLARIWLMDEG TH_1319|M.thermoresistible__bu ELIDLVTAELGSDWPRLVAPAFDARKAVLLDDRWASAREDLVKIWLADED MSMEG_4757|M.smegmatis_MC2_155 ELIDLVTAELGSDWPRLVAPTFDARKAVVFDDRWASAREDLVKLWLAEEG Rv2524c|M.tuberculosis_H37Rv ELIDLVTAELGADWPRLVAPVFDPKKAVVFDDRWASAREDLVKLWLTDEG Mb2553c|M.bovis_AF2122/97 ELIDLVTAELGADWPRLVAPVFDPKKAVVFDDRWASAREDLVKLWLTDEG MMAR_3962|M.marinum_M DLIELVTAELGSDWPRLVAPVFDGKKAVVFDDRWASAREDLVKLWLTDEG MUL_3818|M.ulcerans_Agy99 DLIELVTAELGSDWPRLVAPVFDGKKAVVFDDRWASAREDLVKLWLTDEG MLBr_01191|M.leprae_Br4923 GLIDLVTAELSTDWPRLVAPVFDVKKAVVFDDRWASAREDLVRLWLNDEG MAV_1650|M.avium_104 ELIDLVTAELGADWPRLVAPVFDPKKAVLFDDRWASAREDLVKLWLADEG MAB_1512|M.abscessus_ATCC_1997 ELVELVSAELGSDWPRLVAPTFDGKKAVVFDDRWASAREDLARLWITEES *::**:***.:********.** :***::***********.::*: :*. Mflv_2532|M.gilvum_PYR-GCK DIDADWARLSSRFEGAGHVVGTQATYWQGKALAVGRNVHASLYARAAAGA Mvan_4125|M.vanbaalenii_PYR-1 DIDADWARLSERFEGAGHVVGTQATYWQGKALAAGRTVHASLYARAAAGA TH_1319|M.thermoresistible__bu DIDADWPRLAERFEGTGHVVATQANWWQGKALAAGRNVHASLFGRIAAGA MSMEG_4757|M.smegmatis_MC2_155 DIDAQWEQLSQRFEGTGHVVATQANWWQGKALAAGRNVHASLFGRIAAGA Rv2524c|M.tuberculosis_H37Rv DIDADWPRLAERFEGAGHVVATQATWWQGKSLAAGRQIHASLYGRIAAGA Mb2553c|M.bovis_AF2122/97 DIDADWPRLAERFEGAGHVVATQATWWQGKSLAAGRQIHASLYGRIAAGA MMAR_3962|M.marinum_M DIDADWARLSQRFEGAGHVVATQATWWQGKSLAAGRQIHASLYGRIAAGA MUL_3818|M.ulcerans_Agy99 DIDADWARLSQRFEGAGHVVATQATWWQGKSLAAGRQIHASLYGRIAAGA MLBr_01191|M.leprae_Br4923 EIEAQWSHLSERFEGAGHVVATQATWWQGKSLAAGRQIHASLYGRIAAGA MAV_1650|M.avium_104 DIDSQWLHLSERFEGAGHVVATQATWWQGKALSAGRAVHASLYGRIAAGA MAB_1512|M.abscessus_ATCC_1997 EIDGQWESLGLQFEGAGHAVATQANWWQGKSLAQGRNVHASLYGRIAAGA :*:.:* *. :***:**.*.***.:****:*: ** :****:.* **** Mflv_2532|M.gilvum_PYR-GCK ENPGKGRYSDEVAVVTGASKGSIAASVVAQLLDGGATVVATTSRLDDSRL Mvan_4125|M.vanbaalenii_PYR-1 ENPGKGRYHDEVAVVTGASKGSIAASVVAQLLDGGATVVATTSKLDDNRL TH_1319|M.thermoresistible__bu ENPGSGRYSDEVAVVTGASKGSIAAAVVAQLLDGGATVIATTSRLDDDRL MSMEG_4757|M.smegmatis_MC2_155 ENPGKGRYSDEVAVVTGASKGSIAASVVGQLLDGGATVIATTSRLDDDRL Rv2524c|M.tuberculosis_H37Rv ENPEPGRYGGEVAVVTGASKGSIAASVVARLLDGGATVIATTSKLDEERL Mb2553c|M.bovis_AF2122/97 ENPEPGRYGGEVAVVTGASKGSIAASVVARLLDGGATVIATTSKLDEERL MMAR_3962|M.marinum_M ENPDPGPDSSEVAVVTGASKGSIAASVVARLLDGGATVIATTSKLDDERL MUL_3818|M.ulcerans_Agy99 ENPDPGPDSSEVAVVTGASKGSIAASVVARLLDGGATVIATTSKLDDERL MLBr_01191|M.leprae_Br4923 QNPDRGLYSSEIAVVTGASKGSIAASVAARLLDGGATVIATTSKLDEERI MAV_1650|M.avium_104 ENPDPGRYSHEVAVVTGASKGSIASSVVARLLDGGATVIATTSKLDDERL MAB_1512|M.abscessus_ATCC_1997 ESPEQGKWGSEVAVVTGASKGSIAASVVAALLSGGATVIATTSRLDEDRL :.* * *:************::*.. **.*****:****:**:.*: Mflv_2532|M.gilvum_PYR-GCK GFYRQLYRDNARFGAKLWVLPANMASYNDIDALVDWIGTEQSESLGPKSI Mvan_4125|M.vanbaalenii_PYR-1 AFYRQLYRDSARFGAKLWVLPANMASYNDIDALVEWIGTEQSESLGPKSV TH_1319|M.thermoresistible__bu EFYKSLYRDNARFDAKLWVVPANMASYSDIDALVEWIGSEQVENLGPQSI MSMEG_4757|M.smegmatis_MC2_155 AFYKQLYRDHARFDATLWVVPANMASYSDIDKLVEWVGTEQTESLGPQSI Rv2524c|M.tuberculosis_H37Rv AFYRTLYRDHARYGAALWLVAANMASYSDVDALVEWIGTEQTESLGPQSI Mb2553c|M.bovis_AF2122/97 AFYRTLYRDHARYGAALWLVAANMASYSDVDALVEWIGTEQTESLGPQSI MMAR_3962|M.marinum_M AFYRTLYRDHARYGAALWVVAANMASYSDIDALVEWVGSEQTESLGPQSI MUL_3818|M.ulcerans_Agy99 AFYRTLYRDHARYGAALWVVAANMASYSDIDALVEWVGSEQTESLGPQSI MLBr_01191|M.leprae_Br4923 TFYRALYRDHARYGAALWVVAANMASYSDIDALVEWIGNEQTESLGPQSI MAV_1650|M.avium_104 AFYRGLYRDHARYGAALWVVAANMASYSDIDALVEWIGTEQTESLGPQSI MAB_1512|M.abscessus_ATCC_1997 AFYRNLYRESARFGAKLWVVPANMASYADIDALVQWVGTEQSESLGPMSI **: ***: **:.* **::.****** *:* **:*:*.** *.*** *: Mflv_2532|M.gilvum_PYR-GCK HIKDALTPTLLFPFAAPRVGGDLSEAGARAEMEMKVLLWAVQRLIAGLSH Mvan_4125|M.vanbaalenii_PYR-1 HIKDALTPTLLFPFAAPRVGGDLSDAGSRSEMEMKVLLWAVQRLIGGLSH TH_1319|M.thermoresistible__bu HLKDAQTPTLLFPFAAPRVAGDMSEAGSRAEMEMKVLLWAVERLITGLAT MSMEG_4757|M.smegmatis_MC2_155 HLKDAQTPTLLFPFAAPRVAGDMSEVGSRAEMEMKVLLWAVQRLISGLSK Rv2524c|M.tuberculosis_H37Rv HIKDAQTPTLLFPFAAPRVVGDLSEAGSRAEMEMKVLLWAVQRLIGGLST Mb2553c|M.bovis_AF2122/97 HIKDAQTPTLLFPFAAPRVVGDLSEAGSRAEMEMKVLLWAVQRLIGGLST MMAR_3962|M.marinum_M HIKDAQTPTLLFPFAAPRVVGDLSEAGSRSEMEMKVLLWAVQRLIGGLST MUL_3818|M.ulcerans_Agy99 HIKDAQTPTLLFPFAAPRVVGDLSEAGSRSEMEMKVLLWAVQRLIGGLST MLBr_01191|M.leprae_Br4923 HIKDAQTPTLLFPFAAPRVIGDLSEAGARSEIEMKVLLWAVQRLIVGLSK MAV_1650|M.avium_104 HIKDAQTPTLLFPFAAPRVAGDLSEAGSRSEMEMKVLLWAVQRLIGGLSK MAB_1512|M.abscessus_ATCC_1997 HLKDAQTPTLLFPFAAPKVVGDLSEAGSRAEMEMKVLLWAVQRLIGGLSA *:*** ***********:* **:*:.*:*:*:*********:*** **: Mflv_2532|M.gilvum_PYR-GCK IGADRDIAARLHVVLPGSPNRGMFGGDGAYGESKSALDAVVSRWKAETSW Mvan_4125|M.vanbaalenii_PYR-1 ISADRDIAARLHVVLPGSPNRGMFGGDGAYGESKAALDAVVSRWKAETSW TH_1319|M.thermoresistible__bu IGAERDIASRLHVVLPGSPNRGMFGGDGAYGEAKAALDAVVTRWKAESSW MSMEG_4757|M.smegmatis_MC2_155 IGAERDIASRLHVVLPGSPNRGMFGGDGAYGEAKSALDALENRWSAEKSW Rv2524c|M.tuberculosis_H37Rv IGAERDIASRLHVVLPGSPNRGMFGGDGAYGEAKSALDAVVSRWHAESSW Mb2553c|M.bovis_AF2122/97 IGAERDIASRLHVVLPGSPNRGMFGGDGAYGEAKSALDAVVSRWHAESSW MMAR_3962|M.marinum_M IGAERDIASRLHVVLPGSPNRGMFGGDGAYGEAKSALDAVVSRWHAESSW MUL_3818|M.ulcerans_Agy99 IGAERDIASRLHVVLPGSPNRGMFGGDGAYGEAKSALDAVVSRWHAESSW MLBr_01191|M.leprae_Br4923 IGTERDVASRLHVVLPGSPNRGMFGGDGAYGEAKSALDAVVSRWHAESSW MAV_1650|M.avium_104 IGAERDIASRLHVVLPGSPNRGMFGGDGAYGEAKSALDALVSRWHAESSW MAB_1512|M.abscessus_ATCC_1997 IGAERDIASRLHVVLPGSPNRGMFGGDGAYGESKAALDALVTRWKAESSW *.::**:*:***********************:*:****: .** **.** Mflv_2532|M.gilvum_PYR-GCK AQRVSLAHALIGWTRGTGLMGHNDVIVDAVEEAGVTTYSTEQMAAMLLDL Mvan_4125|M.vanbaalenii_PYR-1 AQRVSLAHALIGWTRGTGLMGHNDVIVDAVEEAGVTTYSTEQMASMLLDL TH_1319|M.thermoresistible__bu AQRVSLAHALIGWTKGTGLMGHNDAIVDAVEAAGLTTYTTSEMASKLLSL MSMEG_4757|M.smegmatis_MC2_155 AERVSLAHALIGWTKGTGLMGQNDAIVSAVEEAGVTTYTTDEMAAMLLDL Rv2524c|M.tuberculosis_H37Rv AARVSLAHALIGWTRGTGLMGHNDAIVAAVEEAGVTTYSTDEMAALLLDL Mb2553c|M.bovis_AF2122/97 AARVSLAHALIGWTRGTGLMGHNDAIVAAVEEAGVTTYSTDEMAALLLDL MMAR_3962|M.marinum_M AARVSLAHALIGWTRGTGLMGHNDAIVSAVEEAGVTTYSTDEMAAMLLGL MUL_3818|M.ulcerans_Agy99 AARVSLAHALIGWTRGTGLMGHNDAIVSAVEEAGVTTYSTDEMAAMLLGL MLBr_01191|M.leprae_Br4923 AARVSLAHALIGWTRGTGLMGHNDVIVSAVEEAGVTTYSTDEMAAMLLDL MAV_1650|M.avium_104 AARVSLAHALIGWTRGTGLMGHNDAIVDAVEQAGVTTYSTDEMAAMLLDL MAB_1512|M.abscessus_ATCC_1997 ASRVSLAHALIGWTRGTGLMGHNDAIVTAVEEAGVTTYSTADMASMLLAL * ************:******:**.** *** **:***:* :**: ** * Mflv_2532|M.gilvum_PYR-GCK CDVEHKVAAAREPVLADLTGGLAEVELDLSALAAKARENAAVADEDETV- Mvan_4125|M.vanbaalenii_PYR-1 CDVETKVAAAREPVLADLTGGLAEVELDLSALATKAREEATSTSADEDG- TH_1319|M.thermoresistible__bu CDAEAKAAAAREPIEADFTGGLGDIDIDMAELAAKAREEHAASTQQD--- MSMEG_4757|M.smegmatis_MC2_155 CTVETKVAAAGAPVKVDLTGGLGDIKIDMAELAAKAREEMSGAADES--- Rv2524c|M.tuberculosis_H37Rv CDAESKVAAARSPIKADLTGGLAEANLDMAELAAKAREQMSAAAAVDED- Mb2553c|M.bovis_AF2122/97 CDAESKVAAARSPIKADLTGGLAEANLDMAELAAKAREQMSAAAAVDED- MMAR_3962|M.marinum_M CDVESKVAAASTPIKADLTGGLAEANLDMAELAAKAREEMSTEATADDE- MUL_3818|M.ulcerans_Agy99 CDVESKVAAASTPIKADLTGGLAEANLDMAELAAKAREEMSTEATADDE- MLBr_01191|M.leprae_Br4923 CNAESKVAAAGTPITVDLTGGLGEVDLDMAELAAKAREDHAAQAAEDEAT MAV_1650|M.avium_104 CDVESKVAAASAPIKADLTGGLGEADLDMAELAAKAREQATGAEPAADD- MAB_1512|M.abscessus_ATCC_1997 CTPEARVQAAQAPVEKDLTGGLAEVQLDMAELAAKAREDLESRAAKSNEI * * :. ** *: *:****.: .:*:: **:****: Mflv_2532|M.gilvum_PYR-GCK EDEAADHTIAALPSPPRPPAPAPVPDWADLDVDPADLVVIVGGAELGPYG Mvan_4125|M.vanbaalenii_PYR-1 DDEAADHLIAALPSPPRPVTPAHAPEWADLDVDPADLVVIVGGAELGPYG TH_1319|M.thermoresistible__bu DEEPAAATIAALPSPPRVPVPAPAPQWADLDIDPADMVVIVGGAELGPYG MSMEG_4757|M.smegmatis_MC2_155 DDEAPAGTIRALPSPPRGYNPAPAPEWDDLDVDPADLVVIVGGAELGPYG Rv2524c|M.tuberculosis_H37Rv --AEAPGAIAALPSPPRGFTPAPPPQWDDLDVDPADLVVIVGGAEIGPYG Mb2553c|M.bovis_AF2122/97 --AEAPGAIAALPSPPRGFTPAPPPQWDDLDVDPADLVVIVGGAEIGPYG MMAR_3962|M.marinum_M --ESTEGAIPALPSPPRGYTPAPPPHWDDLDVDPSDLVVIVGGAELGPYG MUL_3818|M.ulcerans_Agy99 --ESTEGAIPALPSPPRGYTPAPPPHWDDLDVDPSDLVVIVGGAELGPYG MLBr_01191|M.leprae_Br4923 EASEVAGTIAALPSPPRGYTPASP-HWDDLDVDPADLVVIVGGAEIGPYG MAV_1650|M.avium_104 --GPTPGTIAALPSPPRGFTPAPPPEWADLDVDPADLVVIVGGAELGPYG MAB_1512|M.abscessus_ATCC_1997 DDEDDPNVIAALPSPPRGYTSTLPPEWADLDVDPADLVVIVGGGELGPLG * ******* .: .* ***:**:*:******.*:** * Mflv_2532|M.gilvum_PYR-GCK SSRTRFEMEVDNELSAAGVLELAWTTGLIKWEDDPQPGWYDTESGDLVDE Mvan_4125|M.vanbaalenii_PYR-1 SSRTRFEMEVDNELSAAGVLELAWTTGLVKWEDDPQPGWYDTESGDLVDE TH_1319|M.thermoresistible__bu SSRTRYEMEVDNELSAAGVLELAWTTGMITWENDPQPGWYDTETGELVPE MSMEG_4757|M.smegmatis_MC2_155 SSRTRFEMEVSGELSAAGVLELAWTTGMVKWEDDPKAGWYDTETGELVPE Rv2524c|M.tuberculosis_H37Rv SSRTRFEMEVENELSAAGVLELAWTTGLIRWEDDPQPGWYDTESGEMVDE Mb2553c|M.bovis_AF2122/97 SSRTRFEMEVENELSAAGVLELAWTTGLIRWEDDPQPGWYDTESGEMVDE MMAR_3962|M.marinum_M SSRTRFEMEVENELSAAGVLELAWTTGLVRWEDDPQPGWYDTGTGELVDE MUL_3818|M.ulcerans_Agy99 SSRTRFEMEVENELSAAGVLELAWTTGLVRWEDDPQPGWYDTGTGELVDE MLBr_01191|M.leprae_Br4923 SSRTRFEMEVAGELSAAGVLELVWTTGLIRWEDDPQPGWYDTESGELVDE MAV_1650|M.avium_104 SSRTRFEMEVDNELSAAGVLELAWTTGLIRWEDDPQPGWYDTESGELVDE MAB_1512|M.abscessus_ATCC_1997 SSRTRYEMEVDDELSAAGVLELAWTTGLVKWENDPEAGWYDTETGELVPE *****:**** .**********.****:: **:**:.***** :*::* * Mflv_2532|M.gilvum_PYR-GCK ADLVERYHDVVVERVGIREFVGDAAIDPDHSAPLLVSVFLDKDFSFVVSS Mvan_4125|M.vanbaalenii_PYR-1 SELVERYHDAVVERCGIREFVDDGAIDPDHGSPLLVSVFLDKDFRFVVSS TH_1319|M.thermoresistible__bu EELVERYHDAVVERCGIREFVDDGAIDPDHASPLLVSVFLDKDFTFVVSS MSMEG_4757|M.smegmatis_MC2_155 CEIVERYHDAVVERCGIREFVDDGAIDPDHASPLLVSVFLDKDFTFVVSS Rv2524c|M.tuberculosis_H37Rv SELVQRYHDAVVQRVGIREFVDDGAIDPDHASPLLVSVFLEKDFAFVVSS Mb2553c|M.bovis_AF2122/97 SELVQRYHDAVVQRVGIREFVDDGAIDPDHASPLLVSVFLEKDFAFVVSS MMAR_3962|M.marinum_M AELVERYHDTVVERVGIREFVDDGTIDSDHSSPLLVSVFLDKDFSFVVSS MUL_3818|M.ulcerans_Agy99 AELVERYHDVVVERVGIREFVDDGTIDSDHSSPLLVSVFLDKDFSFVVSS MLBr_01191|M.leprae_Br4923 SELVERYHDTVVQRCGIREFVDDGTIDPDHAYPLLVSVFLDKDFAFVVSS MAV_1650|M.avium_104 SELVERYHDTVVARCGIREFVDDGAIDPDHASPLLVSVFLDKDFTFVVSS MAB_1512|M.abscessus_ATCC_1997 AELVERYHDKVVANIGVREFVDDGAIDPDHASPLLVSVFLDKDFTFTVST ::*:**** ** . *:****.*.:**.**. ********:*** *.**: Mflv_2532|M.gilvum_PYR-GCK EADARAFVQFDPEHTVISPVPDSSDWTVTRKAGTEIRVPRKAKLSRTVGA Mvan_4125|M.vanbaalenii_PYR-1 EADARAFVQFDPEHTLARPIPDSGDWEVIRKAGTEIRVPRKTKLSRTVGA TH_1319|M.thermoresistible__bu EADARAFVEFDPEHTVIRPVPDSTDWQVTRKAGTEIRVPRKTKLSRTVGA MSMEG_4757|M.smegmatis_MC2_155 EADARAFVQFDPEHTVARPLPDSSDWEVTRKAGTEIRVPRKTKLSRTVGA Rv2524c|M.tuberculosis_H37Rv EADARAFVEFDPEHTVIRPVPDSTDWQVIRKAGTEIRVPRKTKLSRVVGG Mb2553c|M.bovis_AF2122/97 EADARAFVEFDPEHTVIRPVPDSTDWQVIRKAGTEIRVPRKTKLSRVVGG MMAR_3962|M.marinum_M EADARAFADFDPEHTVIRPVPDSGDWQVIRKAGTEIRVPRKTTLSRVVGA MUL_3818|M.ulcerans_Agy99 EADARAFADFDPEHTVIRPVPDSGDWQVIRKAGTEIRVPRKTTLSRVVGA MLBr_01191|M.leprae_Br4923 EADARAFVEFDPEHTVIRPVPDSSDWQVIRKAGTEIRVPRKMKLSRVVGG MAV_1650|M.avium_104 EADARAFVEFDPEHTIIRPVPDSSDWQVTRKAGTEIRVPRKTKLSRVVGG MAB_1512|M.abscessus_ATCC_1997 EAEAREFVKWDPEHTVIQPLADGSDWQVTRKSGTEVRVPRKTKLSRTVGA **:** *..:*****: *:.*. ** * **:***:***** .***.**. Mflv_2532|M.gilvum_PYR-GCK QIPTGFDPQVWGVTPDMANSIDRVALWNLVATVDAFLSAGFSPTELMRWV Mvan_4125|M.vanbaalenii_PYR-1 QIPTGFDPTVWGISPDMATSVDRVALWNIVATVDAFLSSGFTPSELMRWV TH_1319|M.thermoresistible__bu QIPTGWDPTVWGISQDMANSIDRVALWNIVATVDAFLSAGFTPAELMRWV MSMEG_4757|M.smegmatis_MC2_155 QIPTGFDPTVWGISPDMASSIDRVALWNIVATVDAFLSSGFTPTELMRWV Rv2524c|M.tuberculosis_H37Rv QIPTGFDPTVWGISADMAGSIDRLAVWNMVATVDAFLSSGFSPAEVMRYV Mb2553c|M.bovis_AF2122/97 QIPTGFDPTVWGISADMAGSIDRLAVWNMVATVDAFLSSGFSPAEVMRYV MMAR_3962|M.marinum_M QLPTGFDPTVWGISQDMASSIDRVAVWNIVATVDAFLSAGFSPTEVMRYV MUL_3818|M.ulcerans_Agy99 QLPTGFDPTVWGISQDMASSIDRVAVWNIVATVDAFLSAGFSPTEVMRYV MLBr_01191|M.leprae_Br4923 QIPTGFDPTVWGISPDMVSSIDRVAVWSIVATVDAFLSAGFTPAEVMRYV MAV_1650|M.avium_104 QLPTGFDPTVWGISPDMASSIDRVAVWNIVATVDAFLSAGFSPAEVMRYV MAB_1512|M.abscessus_ATCC_1997 QIPTGFDPTVWGITPDMVSSIDRVALWNMVATVDAFLSAGFTPTELMRWV *:***:** ***:: **. *:**:*:*.:*********:**:*:*:**:* Mflv_2532|M.gilvum_PYR-GCK HPSLVASTQGTGMGGLTSMQTMFHGNLLDKNKPNDILQETLPNVVAAHVI Mvan_4125|M.vanbaalenii_PYR-1 HPSLVASTQGTGMGGMTSMQTMFHGNLLGRSKPNDILQEVLPNVVAAHVM TH_1319|M.thermoresistible__bu HPTQVASTQGTGMGGMTSMQTMYHGNLLGRNKPNDILQEVLPNVVAAHVV MSMEG_4757|M.smegmatis_MC2_155 HPSQVASTQGTGMGGMTSMQTMYHGNLLGRAKPNDILQEVLPNVVAAHVM Rv2524c|M.tuberculosis_H37Rv HPSLVANTQGTGMGGGTSMQTMYHGNLLGRNKPNDIFQEVLPNIIAAHVV Mb2553c|M.bovis_AF2122/97 HPSLVANTQGTGMGGGTSMQTMYHGNLLGRNKPNDIFQEVLPNIIAAHVV MMAR_3962|M.marinum_M HPSLVANTMGTGMGGGTSMQTMYHGNLLGRNKPNDIFQEILPNIVAAHVV MUL_3818|M.ulcerans_Agy99 HPSLVANTMGTGVGGGTSMQTMYHGNLLGRNKPNDIFQEILPNIVAAHVV MLBr_01191|M.leprae_Br4923 HPSLVANTMGTGMGGGTSIQRLYHSSLLGRNKPNDIFQEILPNIVAAHVV MAV_1650|M.avium_104 HPSLVANTMGTGMGGGTSMQTLYHGNLLGRNKPNDIFQEILPNIVAAHVV MAB_1512|M.abscessus_ATCC_1997 HPSQVANTQGTGMGGMTSMQTMYHGNLLGRNKPNDILQEVLPNVVAAHVV **: **.* ***:** **:* ::*..**.: *****:** ***::****: Mflv_2532|M.gilvum_PYR-GCK QSYVGSYGSMIHPVGACATAAVSLEEGVDKIRLGKAELVVTGGYDDLTLE Mvan_4125|M.vanbaalenii_PYR-1 QSYVGGYGAMVHPVGACATAAVSVEEGVDKIRLGKAELVVAGGFDDMTLE TH_1319|M.thermoresistible__bu QSYIGSYGAMIHPVAACATAAVSVEEGVDKIRLGKAELVVTGGFDDLTLE MSMEG_4757|M.smegmatis_MC2_155 QSYVGGYGAMVHPVGACATAAVSVEEGVDKIKLGKADLVIAGGFDDLTLE Rv2524c|M.tuberculosis_H37Rv QSYVGSYGAMIHPVAACATAAVSVEEGVDKIRLGKAQLVVAGGLDDLTLE Mb2553c|M.bovis_AF2122/97 QSYVGSYGAMIHPVAACATAAVSVEEGVDKIRLGKAQLVVAGGLDDLTLE MMAR_3962|M.marinum_M QSYIGSYGSMIHPVAACATAAVSVEEGVDKIRLGKAEMVVAGGIDDLTLE MUL_3818|M.ulcerans_Agy99 QSYIGSYGSMIHPVAACATAAVSVEEGVDKIRLGKAEMVVAGGIDDLTLE MLBr_01191|M.leprae_Br4923 QSYIGSYGSMIHPVAACATAAVSVEEGVDKIRLGKAELVVAGGIDDLTLE MAV_1650|M.avium_104 QSYIGSYGAMIHPVAACATAAVSVEEGVDKIRLGKAEMVVAGGIDDLTLE MAB_1512|M.abscessus_ATCC_1997 QSYVGSYGAMIHPVAACATAAVSVEEGVDKIRLGKAQLALAGGFDDLTLE ***:*.**:*:***.********:*******:****::.::** **:*** Mflv_2532|M.gilvum_PYR-GCK AVIGFGDMAATADTEVMRAKGISDARFSRANDRRRLGFVEAQGGGTILLA Mvan_4125|M.vanbaalenii_PYR-1 AIIGFGDMAATADTEMMRAKGISDSKFSRANDRRRLGFLEAEGGGTVLLA TH_1319|M.thermoresistible__bu AIIGFGDMAATAETAMMRAKGISDSKFSRANDRRRLGFVEAQGGGTILLA MSMEG_4757|M.smegmatis_MC2_155 AIIGFGDMAATADTEMMRAKGISDSKFSRANDRRRLGFLEAQGGGTILLA Rv2524c|M.tuberculosis_H37Rv GIIGFGDMAATADTSMMCGRGIHDSKFSRPNDRRRLGFVEAQGGGTILLA Mb2553c|M.bovis_AF2122/97 GIIGFGDMAATADTSMMRGRGIHDSKFSRPNDRRRLGFVEAQGGGTILLA MMAR_3962|M.marinum_M GIIGFGDMAATADTAMMRGRGIADSKFSRPNDRRRLGFVEAQGGGTILLA MUL_3818|M.ulcerans_Agy99 GIIGFGDMAATADTAMMRGRGIADSKFSRPNDRRRLGFVEAQGGGTILLA MLBr_01191|M.leprae_Br4923 GIIGFGDMAATADTAMMRGRGIHDSKFSRPNDRRRLGFVEAQGGGTILLA MAV_1650|M.avium_104 GIIGFGDMAATADTGMMRGRGISDAKFSRPNDRRRLGFVEAQGGGTILLA MAB_1512|M.abscessus_ATCC_1997 AIIGFGDMAATADTEMMRAKGIADKRFSRANDRRRLGFVEAQGGGSVLLA .:**********:* :* .:** * :***.********:**:***::*** Mflv_2532|M.gilvum_PYR-GCK RGDLALRMGLPVLAVVAYAQSYADGVHTSIPAPGLGALGAGRGGRESVLA Mvan_4125|M.vanbaalenii_PYR-1 RGDLALKMGLPVLAVVGYAQSFADGVHTSIPAPGLGALGAGRGGRDSVLA TH_1319|M.thermoresistible__bu RGDLALKMGLPVLAVVAYAQSFGDGVHTSIPAPGLGALGAGRGGRDSALA MSMEG_4757|M.smegmatis_MC2_155 RGDLALKMGLPVLAVVGYAQSFADGVHTSIPAPGLGALGAARGGRESTLA Rv2524c|M.tuberculosis_H37Rv RGDLALRMGLPVLAVVAFAQSFGDGVHTSIPAPGLGALGAGRGGKDSPLA Mb2553c|M.bovis_AF2122/97 RGDLALRMGLPVLAVVAFAQSFGDGVHTSIPAPGLGALGAGRGGKDSPLA MMAR_3962|M.marinum_M RGDLALKMGLPVLAVVAFAQSFGDGVHTSIPAPGLGALGAGRGGRDSALA MUL_3818|M.ulcerans_Agy99 RGDLALKMGLPVLAVVAFAQSFGDGVHTSIPAPGLGALGAGRGGRDSALA MLBr_01191|M.leprae_Br4923 RGDLALKMGLPVFAVVAFAQSFGDGVHTSIPAPGLGALGAGRGGKDSPLV MAV_1650|M.avium_104 RGDLALKMGLPVLAVVAYAQSFADGVHTSIPAPGLGALGAGRGGKDSPLA MAB_1512|M.abscessus_ATCC_1997 RGDLALKMGLPVLAVVAYAQSFGDGVHTSIPAPGLGALAAGRGGKDSDLA ******:*****:***.:***:.***************.*.***::* *. Mflv_2532|M.gilvum_PYR-GCK RSLNKLGVGADDIAVISKHDTSTLANDPNEQELHERLADSLGRSDGAPLF Mvan_4125|M.vanbaalenii_PYR-1 RSLAKLGVGADDIAVISKHDTSTLANDPNETELHERLAASLGRSDGAPLF TH_1319|M.thermoresistible__bu RSLARLGVGPDDIAVVSKHDTSTLANDPNETELHERLADSLGRSPGNPMF MSMEG_4757|M.smegmatis_MC2_155 RSLAQLGVGADDIAVISKHDTSTLANDPNETELHERIADSMGRAPGNPLF Rv2524c|M.tuberculosis_H37Rv RALAKLGVAADDVAVISKHDTSTLANDPNETELHERLADALGRSEGAPLF Mb2553c|M.bovis_AF2122/97 RALAKLGVAADDVAVISKHDTSTLANDPNETELHERLADALGRSEGAPLF MMAR_3962|M.marinum_M RALAKLGVGADDIAIISKHDTSTLANDPNETELHERLADSLGRSEGAPLF MUL_3818|M.ulcerans_Agy99 RALAKLGVGADDIAIISKHDTSTLANDPNETELHERLADSLGRSEGAPLF MLBr_01191|M.leprae_Br4923 QSLAKLGVSADDIAVISKHDTSTLANDPNETELHERLADAMGRSAGAPLF MAV_1650|M.avium_104 RALAKLGVGADDVAVISKHDTSTLANDPNETELHERLADSLGRSEGAPLF MAB_1512|M.abscessus_ATCC_1997 RALNKLGVTADDIAVISKHDTSTLANDPNETELHERLAASLGRSDGAPLF ::* :*** .**:*::************** *****:* ::**: * *:* Mflv_2532|M.gilvum_PYR-GCK VVSQKSLTGHAKGGAAVFQTMGLCQILRDGVIPPNRSLDCVDEDLATSAH Mvan_4125|M.vanbaalenii_PYR-1 VISQKSLTGHAKGGAAVFQMMGLCQVLRDGVIPPNRSLDCVDDELATSAH TH_1319|M.thermoresistible__bu VVSQKTLTGHAKGGAAVFQLMGLCQILRDGVVPPNRSLDCVDDELAGSEH MSMEG_4757|M.smegmatis_MC2_155 IVSQKTLTGHAKGGAAVFQMMGLCQILRDGVIPPNRSLDCVDDELATSGH Rv2524c|M.tuberculosis_H37Rv VVSQKSLTGHAKGGAAVFQMMGLCQILRDGVIPPNRSLDCVDDELAGSAH Mb2553c|M.bovis_AF2122/97 VVSQKSLTGHAKGGAAVFQMMGLCQILRDGVIPPNRSLDCVDDELAGSAH MMAR_3962|M.marinum_M VVSQKSMTGHAKGGAAVFQMMGLCQILRDGVIPPNRSLDCVDDELAGAAH MUL_3818|M.ulcerans_Agy99 VVSQKSMTGHAKGGAAVFQMMGLCQILRDGVIPPNRSLDCVDDELAGAAH MLBr_01191|M.leprae_Br4923 VVSQKSLTGHAKGGAAVFQMMGLCQMLRDGVIPPNRSLDCVDEELAGAAH MAV_1650|M.avium_104 VVSQKSLTGHAKGGAAVFQMMGLCQMLRDGVIPPNRSLDCVDDELAGSAH MAB_1512|M.abscessus_ATCC_1997 IISQKNLTGHAKGGAAVFQMLGLCQVLRDGVIPPNRSLDCVDDELSTSQH ::***.:************ :****:*****:**********::*: : * Mflv_2532|M.gilvum_PYR-GCK FVWPRETLRLGEKYPLKAGLITSLGFGHVSGLIALVHPQAFLATLTAEQR Mvan_4125|M.vanbaalenii_PYR-1 FVWPRETLRLGEKYPLKAGLVTSLGFGHVSGLIALVHPQAFLATLTPEQR TH_1319|M.thermoresistible__bu FVWPRETLRLGEKFPLKAGLVTSLGFGHVSGLIALVHPQAFLAALSPEER MSMEG_4757|M.smegmatis_MC2_155 FVWVREPLDLRGKFPLKAGLVTSLGFGHVSGLVALVHPEAFIAALDPSER Rv2524c|M.tuberculosis_H37Rv FVWVRDTLRLGGKFPLKAGMLTSLGFGHVSGLVALVHPQAFIASLDPAQR Mb2553c|M.bovis_AF2122/97 FVWVRDTLRLGGKFPLKAGMLTSLGFGHVSGLVALVHPQAFIASLDPAQR MMAR_3962|M.marinum_M FVWVRDALRLGGKFPLKAGMLTSLGFGHVSGLVALVHPQAFIASLAPEQR MUL_3818|M.ulcerans_Agy99 FVWVRDALRLGGKFPLKAGMLTSLGFGHVSGLVALVHPQAFIASLAPEQR MLBr_01191|M.leprae_Br4923 FVWLRDTLRLGEKFPLKAGMLTSLGFGHVSGLVALVHPQAFIAALDPGQR MAV_1650|M.avium_104 FVWVRETLRLGDKFPLKAGMVTSLGFGHVSGLVALVHPQAFLAALDPEQR MAB_1512|M.abscessus_ATCC_1997 FVWLRESLPLKEKLPLKAGLVTSLGFGHVSGLVALVHPQAFIASLRPEDR *** *:.* * * *****::***********:*****:**:*:* . :* Mflv_2532|M.gilvum_PYR-GCK ADYTALAQERTLAGQRRLVSAIAGGRPMYERPDGRRFDSDH--PEKTQEA Mvan_4125|M.vanbaalenii_PYR-1 AAYTAQAQERVLAGQRRLASAIAGGRPMFERPADRRFDHDE--SEKAQEA TH_1319|M.thermoresistible__bu EAYTKRAEQRLLAGQRRLASAIAGGPPMYEKPSGRRFDQDV--PEKRQEA MSMEG_4757|M.smegmatis_MC2_155 EDYRTRAEQRMLAGQRRLVSAIAGGRPMYEKPADRRFDHDV--PEKRQEA Rv2524c|M.tuberculosis_H37Rv ADYQRRADARLLAGQRRLASAIAGGAPMYQRPGDRRFDHHA--PERPQEA Mb2553c|M.bovis_AF2122/97 ADYQRRADARLLAGQRRLASAIAGGAPMYQRPGDRRFDHHA--PERPQEA MMAR_3962|M.marinum_M ADYQRRADTRLLAGQRRLASAMAGGEPMYQRPPDRRFDHDT--AEKPQEA MUL_3818|M.ulcerans_Agy99 ADYERRADTRLLAGQRRLASAMAGGEPMYQRPPDRRFDHDT--AEKPQEA MLBr_01191|M.leprae_Br4923 DDYQRRANVRLLAGQRRLASAIAGGAPMYERPPDRRFDHHV--PEKLQEA MAV_1650|M.avium_104 ADYQQRANARLLAGQRRLVSAIAGGAPMYQRPPDRRFDHDV--PEKRQEA MAB_1512|M.abscessus_ATCC_1997 ADYETRSRERVLAGQRRLASAMAGGRPMYERPDGRRFDHDHDESEKRQEA * : * *******.**:*** **:::* .**** . .*: *** Mflv_2532|M.gilvum_PYR-GCK GMLLDVASRLDENGVYRR------ Mvan_4125|M.vanbaalenii_PYR-1 AMLLDAASRLGEDGVYRR------ TH_1319|M.thermoresistible__bu AMLLSTDARLGEDGVYVLGGDVGA MSMEG_4757|M.smegmatis_MC2_155 AMLLSTDARLGENDQYVL------ Rv2524c|M.tuberculosis_H37Rv SMLLNPAARLGDGEAYIG------ Mb2553c|M.bovis_AF2122/97 SMLLNPAARLGDGEAYIG------ MMAR_3962|M.marinum_M AMLLNPAARLGDGEAYIG------ MUL_3818|M.ulcerans_Agy99 AMLLNPAARLGDGEAYIG------ MLBr_01191|M.leprae_Br4923 AMLLNPAARLGDGDAYIG------ MAV_1650|M.avium_104 AMLLDPASRLGDGDAYQVSAG--- MAB_1512|M.abscessus_ATCC_1997 SMLLDPGARLSEDEVYHR------ .***. :**.:. *