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M. tuberculosis H37Rv Rv2476c (gdh)

annotation: PROBABLE NAD-DEPENDENT GLUTAMATE DEHYDROGENASE GDH (NAD-GDH) (NAD-DEPENDENT GLUTAMIC DEHYDROGENASE)
coordinates: 2777388 - 2782262
length: 1624

TIDPGAKQDVEAWTTFTASADIPDWISKAYIDSYRGPRDDSSEATKAAEASWLPASLLTPAMLGAHYRLG
RHRAAGESCVAVYRADDPAGFGPALQVVAEHGGMLMDSVTVLLHRLGIAYAAILTPVFDVHRSPTGELLR
IEPKAEGTSPHLGEAWMHVALSPAVDHKGLAEVERLLPKVLADVQRVATDATALIATLSELAGEVESNAG
GRFSAPDRQDVGELLRWLGDGNFLLLGYQRCRVADGMVYGEGSSGMGVLRGRTGSRPRLTDDDKLLVLAQ
ARVGSYLRYGAYPYAIAVREYVDGSVVEHRFVGLFSVAAMNADVLEIPTISRRVREALAMAESDPSHPGQ
LLLDVIQTVPRPELFTLSAQRLLTMARAVVDLGSQRQALLFLRADRLQYFVSCLVYMPRDRYTTAVRMQF
EDILVREFGGTRLEFTARVSESPWALMHFMVRLPEVGVAGEGAAAPPVDVSEANRIRIQGLLTEAARTWA
DRLIGAAAAAGSVGQADAMHYAAAFSEAYKQAVTPADAIGDIAVITELTDDSVKLVFSERDEQGVAQLTW
FLGGRTASLSQLLPMLQSMGVVVLEERPFSVTRPDGLPVWIYQFKISPHPTIPLAPTVAERAATAHRFAE
AVTAIWHGRVEIDRFNELVMRAGLTWQQVVLLRAYAKYLRQAGFPYSQSYIESVLNEHPATVRSLVDLFE
ALFVPVPSGSASNRDAQAAAAAVAADIDALVSLDTDRILRAFASLVQATLRTNYFVTRQGSARCRDVLAL
KLNAQLIDELPLPRPRYEIFVYSPRVEGVHLRFGPVARGGLRWSDRRDDFRTEILGLVKAQAVKNAVIVP
VGAKGGFVVKRPPLPTGDPAADRDATRAEGVACYQLFISGLLDVTDNVDHATASVNPPPEVVRRDGDDAY
LVVAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITARGAWEAVKRHFREIGIDTQTQD
FTVVGIGDMSGDVFGNGMLLSKHIRLIAAFDHRHIFLDPNPDAAVSWAERRRMFELPRSSWSDYDRSLIS
EGGGVYSREQKAIPLSAQVRAVLGIDGSVDGGAAEMAPPNLIRAILRAPVDLLFNGGIGTYIKAESESDA
DVGDRANDPVRVNANQVRAKVIGEGGNLGVTALGRVEFDLSGGRINTDALDNSAGVDCSDHEVNIKILID
SLVSAGTVKADERTQLLESMTDEVAQLVLADNEDQNDLMGTSRANAASLLPVHAMQIKYLVAERGVNREL
EALPSEKEIARRSEAGIGLTSPELATLMAHVKLGLKEEVLATELPDQDVFASRLPRYFPTALRERFTPEI
RSHQLRREIVTTMLINDLVDTAGITYAFRIAEDVGVTPIDAVRTYVATDAIFGVGHIWRRIRAANLPIAL
SDRLTLDTRRLIDRAGRWLLNYRPQPLAVGAEINRFAAMVKALTPRMSEWLRGDDKAIVEKTAAEFASQG
VPEDLAYRVSTGLYRYSLLDIIDIADIADIDAAEVADTYFALMDRLGTDGLLTAVSQLPRHDRWHSLARL
AIRDDIYGALRSLCFDVLAVGEPGESSEQKIAEWEHLSASRVARARRTLDDIRASGQKDLATLSVAARQI
RRMTRTSGRGISG*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv2476cgdh-100% (1624)PROBABLE NAD-DEPENDENT GLUTAMATE DEHYDROGENASE GDH (NAD-GDH) (NAD-DEPENDENT GLUTAMIC DEHYDROGENASE)

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2503cgdh0.099.88% (1624) NAD-dependent glutamate dehydrogenase
M. gilvum PYR-GCKMflv_2569-0.070.25% (1637) NAD-glutamate dehydrogenase
M. leprae Br4923MLBr_01249-0.081.46% (1634) hypothetical protein MLBr_01249
M. abscessus ATCC 19977MAB_1561-0.063.03% (1566) NAD-dependent glutamate dehydrogenase
M. marinum MMMAR_3829gdh0.084.26% (1626) NAD-dependent glutamate dehydrogenase Gdh
M. avium 104MAV_1696-0.083.62% (1624) NAD-glutamate dehydrogenase
M. smegmatis MC2 155MSMEG_4699-0.071.88% (1604) NAD-glutamate dehydrogenase
M. thermoresistible (build 8)TH_0917-0.077.81% (897) PROBABLE NAD-DEPENDENT GLUTAMATE DEHYDROGENASE GDH (NAD-GDH)
M. ulcerans Agy99-----
M. vanbaalenii PYR-1Mvan_4069-0.070.43% (1640) NAD-glutamate dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2569|M.gilvum_PYR-GCK          ---------------MSLNPGAVN---GATG-AVGAEMVERLIPAYLATY
Mvan_4069|M.vanbaalenii_PYR-1       ---------------MSLNPGAIN---GSVGPEVSSEVIDRLLPAYLATY
MSMEG_4699|M.smegmatis_MC2_155      -------------------------------------MIRRLSVAFLSTY
Rv2476c|M.tuberculosis_H37Rv        ---------------MTIDPGAKQDVEAWTTFTASADIPDWISKAYIDSY
Mb2503c|M.bovis_AF2122/97           ---------------MTIDPGAKQDVEAWTTFTASADIPDWISKAYIDSY
MMAR_3829|M.marinum_M               ---------------MTIDPGAKQDVGAWTAFTQPADIPDWISQAYLDSY
MAV_1696|M.avium_104                MFERIDNRRQLGAIGMTIDPRAQQDLKPWTTFTRQQDIPEWISKAYVESY
MLBr_01249|M.leprae_Br4923          ---------------MTIDPGATHVAELCTTFTQGADVPDWISKAYIDSY
TH_0917|M.thermoresistible__bu      --------------------------------------------------
MAB_1561|M.abscessus_ATCC_1997      ---------------MTVNTGTTTSENTPSANGSGVPTIEALTAAFSGAR
                                                                                      

Mflv_2569|M.gilvum_PYR-GCK          RGPHGGAPGADAAVTGPLRRH-DDGLDTTALVEAQCRLAGTRLPGATNVA
Mvan_4069|M.vanbaalenii_PYR-1       RGPHGGAPGAESAVTGPLRRQGTDTVNGPALVAAHYRLGAQRSPGATRVA
MSMEG_4699|M.smegmatis_MC2_155      RGPQADAPGVTS--TGPLAVAAHDDLVSDDLVAAHYRLASMRAPGETKAA
Rv2476c|M.tuberculosis_H37Rv        -RGPRDDS--SEATKAAEASWLPASLLTPAMLGAHYRLGRHRAAGESCVA
Mb2503c|M.bovis_AF2122/97           -RGPRDDS--SEATKAAEASWLPASLLTPAMLGAHYRLGRHRAAGESCVA
MMAR_3829|M.marinum_M               QRRGEEDS--QASQRAAEA---AASVVTPAMLSAHYRLGQHRPIGESRVA
MAV_1696|M.avium_104                RGPHSDES--GGAEAGPIDLTVPTAIVTPAMLSAHYRLGLHRPDGESRVA
MLBr_01249|M.leprae_Br4923          RGSHGDVR--EAPETSRVN---PNALVTPAMLSAHYRLGQCRPNGRNCVR
TH_0917|M.thermoresistible__bu      --------------------------------------------------
MAB_1561|M.abscessus_ATCC_1997      YMGEMDWD---EPLEPDGHAAPAAPPVREALMRALLRLAARRQPHEIAMA
                                                                                      

Mflv_2569|M.gilvum_PYR-GCK          VYPGDEATGFGPALQIVTDNASLLMDSVTVLLHRIGVAYTAIMNPGFRVR
Mvan_4069|M.vanbaalenii_PYR-1       VHAADVEGGFGPALQVVTDNAAILMDSITVLLHRIGVAYTAIMNPVFRVR
MSMEG_4699|M.smegmatis_MC2_155      VYPGDAGS--GAALQIVTDQAPMLVDSVTVLLHRHGIAYTAIMNPVFRVR
Rv2476c|M.tuberculosis_H37Rv        VYRADDPAGFGPALQVVAEHGGMLMDSVTVLLHRLGIAYAAILTPVFDVH
Mb2503c|M.bovis_AF2122/97           VYRADDPAGFGPALQVVAEHGGMLMDSVTVLLHRLGIAYAAILTPVFDVH
MMAR_3829|M.marinum_M               VYPADDPVGFGPALQVVTEHGSMLMDSVTVLLHRLGVGYTTIMTPVFEVH
MAV_1696|M.avium_104                VYPADDPAGFGPALQVVTDHGGMLMDSVTVLLHRLGVPYTAIMTPVFDVH
MLBr_01249|M.leprae_Br4923          VYPADDPAGFGPALQIVTDHGGMVMDSITVLLHRLGVTYTAMMTPVFMVL
TH_0917|M.thermoresistible__bu      --------------------------------------------------
MAB_1561|M.abscessus_ATCC_1997      TYRNGDDAGLGTALQLVTDYTPLLTESITVLLRRQGVAIVDLMDPVFSVE
                                                                                      

Mflv_2569|M.gilvum_PYR-GCK          RGGAGELLDVAPVSDASFSD----GVDETWVHVQLAGSVDRHALAEAEEL
Mvan_4069|M.vanbaalenii_PYR-1       RGAGGELQDIAPASDATFVD----GVDETWVHVQLADSVDRRALAEAEEL
MSMEG_4699|M.smegmatis_MC2_155      RGLDGELLDVRPAAEAAPGD----GADECWILVPITAAADGEALTEATRL
Rv2476c|M.tuberculosis_H37Rv        RSPTGELLRIEPKAEGTSP-----HLGEAWMHVALSPAVDHKGLAEVERL
Mb2503c|M.bovis_AF2122/97           RSPTGELLRIEPKAEGTSP-----HLGEAWMHVALSPAVDHKGLAEVERL
MMAR_3829|M.marinum_M               RGPTGELQRVEPKSLDASP-----YVGEAWIHVQLSPTVEAKALAEVEQL
MAV_1696|M.avium_104                RSPDGDLLSLEPKPQGAPQ-----YAGEAWIHVQLLPSVDSKGLTEAERL
MLBr_01249|M.leprae_Br4923          RSPTGELLGVEPRASSTSHSIEGTWVGEVWIYIQLLPAVDSKSLAEVEQL
TH_0917|M.thermoresistible__bu      --------------------------------------------------
MAB_1561|M.abscessus_ATCC_1997      RAADGTLLSAAPVDHPQSDT---APNAECWIHLQLPPSIDAERLAFIETQ
                                                                                      

Mflv_2569|M.gilvum_PYR-GCK          LPKVLADARQVALDSTDMAAALRILAAELDGDTG-RRFPSPDRKDVAALL
Mvan_4069|M.vanbaalenii_PYR-1       LPRVLADARQVALDSTGMAAALRTLAAELDSDPG-RRFPSPDRKDVAALL
MSMEG_4699|M.smegmatis_MC2_155      VPGILAEARQIGLDSGAMIAALHGLANDLATDLE-GHFPNAERKEVAALL
Rv2476c|M.tuberculosis_H37Rv        LPKVLADVQRVATDATALIATLSELAGEVESNAG-GRFSAPDRQDVGELL
Mb2503c|M.bovis_AF2122/97           LPKVLADVQRVATDATALIATLSELAGEVESNAG-GRFSAPDRQDVGELL
MMAR_3829|M.marinum_M               LPKVLADVQRVAKDAPAMIATLSELAVAVDSDRE-GHYAAPDHQEVAALL
MAV_1696|M.avium_104                LPKVLADVQQVASDASALIAVLDELAAAVEANRD-NHFSAPDRDDVAALL
MLBr_01249|M.leprae_Br4923          LPRTLVDVQRVAADAAALNATLSGLAADVKTNKE-GHFSASDRDDVAALL
TH_0917|M.thermoresistible__bu      --------------------------------------------------
MAB_1561|M.abscessus_ATCC_1997      LPHTLEDGSHVAADTDAMRDAVIELASDLDAAPGNARFSSAELTEVANLL
                                                                                      

Mflv_2569|M.gilvum_PYR-GCK          RWLADGHFVLLGYQRCPVRDGEATVDTSSRLGVLRLRQDVLPQLTQKDEL
Mvan_4069|M.vanbaalenii_PYR-1       RWLADGHFVLLGYQRCPVRDGEATVDPSSRLGVLRLREDVFPQLTNKDEL
MSMEG_4699|M.smegmatis_MC2_155      RWLADGHFVLLGYQQCVVGDGNAEVDPASRLGVLRLRNDVLPPLTDSDDL
Rv2476c|M.tuberculosis_H37Rv        RWLGDGNFLLLGYQRCRVADGMVYGEGSSGMGVLRGRTGSRPRLTDDDKL
Mb2503c|M.bovis_AF2122/97           RWLGDGNFLLLGYQRCRVADGMVYGEGSSGMGVLRGRTGSRPRLTDDDKL
MMAR_3829|M.marinum_M               RWLGNGNFLLLGYQPCEVDDGMVLGDGSTGLGVLRARTGTRPRLTDETKL
MAV_1696|M.avium_104                RWLGNGNFLLLGYQRCRVHDGLVSGDGSPGLGVLRTRTGSRPRLTDDDRL
MLBr_01249|M.leprae_Br4923          HWLGNGNFLLLGYQRCRVHYGLVSCDRSTGLGVLRARTGSRPRLTDDNEL
TH_0917|M.thermoresistible__bu      --------------------------------------------------
MAB_1561|M.abscessus_ATCC_1997      RWLVDGNFTLLGYQRCTVENGHATVDESSRLGLLKRREEVLPQLTHNDQL
                                                                                      

Mflv_2569|M.gilvum_PYR-GCK          LTLAQATIPSFLRYGAYPQIVVVREQSPERDAD---AIEHRFVGLFTVAA
Mvan_4069|M.vanbaalenii_PYR-1       LTLAQATIPSFLRYGTYPQIVVVREQSGDADADDAAAIEHRFVGMFTVAA
MSMEG_4699|M.smegmatis_MC2_155      LVLAQATMPSYLRYGAYPYIVVVRESPG---ASR--VIEHRFVGLFTVAA
Rv2476c|M.tuberculosis_H37Rv        LVLAQARVGSYLRYGAYPYAIAVREYV---DGS---VVEHRFVGLFSVAA
Mb2503c|M.bovis_AF2122/97           LVLAQARVGSYLRYGAYPYAIAVREYV---DGS---VVEHRFVGLFSVAA
MMAR_3829|M.marinum_M               LVLAQARVGSYLRYGAYPYAIAIRESLG--DGN---IVEHRFVGLFTVAA
MAV_1696|M.avium_104                LVLAQSVVGSYLRYGAYPYAIAVREYV---DGA---VIEHRFVGLFTVAA
MLBr_01249|M.leprae_Br4923          LVLAQAAVGNYLRYGAYPYAIAVREYDDGGDGG---IIEHRFVGLFTVAA
TH_0917|M.thermoresistible__bu      --------------------------------------------------
MAB_1561|M.abscessus_ATCC_1997      LVLAQATTPTYLRYAIYPNIVVIRQDNG--SGP---AIEHRLVGVFTVAA
                                                                                      

Mflv_2569|M.gilvum_PYR-GCK          MNANVLEIPLVSRRVNDALAMAHR-DPSHPGQLLLDIIQTIPRSELFALS
Mvan_4069|M.vanbaalenii_PYR-1       MNANVLEIPLVSRRVNDALAMAHR-DPSHPGQLVLDIIQTIPRSELFALS
MSMEG_4699|M.smegmatis_MC2_155      MNANALEIPLISRRVEEALAMAHR-DPSHPGQLLRDIIQTIPRPELFALS
Rv2476c|M.tuberculosis_H37Rv        MNADVLEIPTISRRVREALAMAES-DPSHPGQLLLDVIQTVPRPELFTLS
Mb2503c|M.bovis_AF2122/97           MNADVLEIPTISRRVREALAMAES-DPSHPGQLLLDVIQTVPRPELFTLS
MMAR_3829|M.marinum_M               MNADVLEIPAISHRVRDALELAGN-DPSHPGQLLLDVIQTVPRPELFTLS
MAV_1696|M.avium_104                MNADVLEIPTISRRVREALAMADS-DPIHPGQLLLDVIQTVPRSELFTLS
MLBr_01249|M.leprae_Br4923          MNADVLEIPSISHRVRAALAMANS-DPIYPGQLLLDVIQTVPRSELFTLS
TH_0917|M.thermoresistible__bu      --------------------------------------------------
MAB_1561|M.abscessus_ATCC_1997      MNADVLAIPVVCDRVHQVLGRSDATQDSLAGHMLIEFMQNLPRAELFASS
                                                                                      

Mflv_2569|M.gilvum_PYR-GCK          ARGLLDMAMAVVDLGARRRTLLFMRADPLAHFVSCLVYLPRDRYTTVVRL
Mvan_4069|M.vanbaalenii_PYR-1       ARGLLDMAMAVVDLGSRRRALLFMRADPLAHFVSCLVYLPRDRYTTAVRL
MSMEG_4699|M.smegmatis_MC2_155      SKQLLEMALAVVDLGSRRRTLLFLRADHLAHFVSCLVYLPRDRYTTAVRL
Rv2476c|M.tuberculosis_H37Rv        AQRLLTMARAVVDLGSQRQALLFLRADRLQYFVSCLVYMPRDRYTTAVRM
Mb2503c|M.bovis_AF2122/97           AQRLLTMARAVVDLGSQRQALLFLRADRLQYFVSCLVYMPRDRYTTAVRM
MMAR_3829|M.marinum_M               SEQLLAMAKAVVDLGSQRRALLFLRVDRLQFFVSCLVYLPRDRYTTAVRL
MAV_1696|M.avium_104                SERLLAMAKAVVDLGPQRNALLFLRADSLQYFVSCLVYLPRDRYTTAVRL
MLBr_01249|M.leprae_Br4923          AERLFTMAKEVVDLGSGRRALLFLRADRLQYFVSCLVYVPRDRYTTGVRL
TH_0917|M.thermoresistible__bu      --------------------------------------------------
MAB_1561|M.abscessus_ATCC_1997      VDRLYDIVTASRNIGAHPGSLLFLRADELGNFVTALVYLPRDRYTTTVRL
                                                                                      

Mflv_2569|M.gilvum_PYR-GCK          EMQDILVRELGGVSIDYAARVSESPWAVVHFTVRLPAGLRQHE------V
Mvan_4069|M.vanbaalenii_PYR-1       EMQDILVRELGGVSIDYAARVSESPWAVVHFTVRMPEGSRPQD------I
MSMEG_4699|M.smegmatis_MC2_155      EMQDILVRELGGAGIDYSARVSESPWAVVHFTVRLPEGTAADS------V
Rv2476c|M.tuberculosis_H37Rv        QFEDILVREFGGTRLEFTARVSESPWALMHFMVRLPEVGVAGEGAAAPPV
Mb2503c|M.bovis_AF2122/97           QFEDILVREFGGTRLEFTARVSESPWALMHFMVRLPEVGVAGEGAAAPPV
MMAR_3829|M.marinum_M               QIEDILVREFGGTRLEFTARVSESPWALMHFMVRLPEDVATGS------I
MAV_1696|M.avium_104                QIEDILVREFGGTRLEFTARVSESPWALMHFMVRLPTDDPAAK-----PV
MLBr_01249|M.leprae_Br4923          QIEDILVREFGGTQVEFTARVSESPWALMHFMVRLSEGAATGS------V
TH_0917|M.thermoresistible__bu      --------------------------------------------------
MAB_1561|M.abscessus_ATCC_1997      AMQDTLVRELGGTGIDYTARVSESPWALVHFTVRLPENSPHNS------I
                                                                                      

Mflv_2569|M.gilvum_PYR-GCK          DVSDDNEARIQDLLTEAARTWGDRLMGALPAGG--PVDHGTADHYASAFP
Mvan_4069|M.vanbaalenii_PYR-1       DVSEPNESRIQDLLTEAARTWSDRLLGAVSAGG--EVDQATAEHYASAFS
MSMEG_4699|M.smegmatis_MC2_155      DTSLENESRIQDLLTEATRNWGDRMISAAAAA---SISPAALEHYAHAFP
Rv2476c|M.tuberculosis_H37Rv        DVSEANRIRIQGLLTEAARTWADRLIGAAAAAG--SVGQADAMHYAAAFS
Mb2503c|M.bovis_AF2122/97           DVSEANRIRIQGLLTEAARTWADRLIG-AAAAG--SVGQADAMHYAAAFS
MMAR_3829|M.marinum_M               DVSEANRSRIQALLSEAARTWADRLIG-AASDA--SVRHADAEHYAAAFP
MAV_1696|M.avium_104                DVSEDNRVRIQGLLSEAARTWTDRLVA-AAAEG--AVGHADAEYYADAFP
MLBr_01249|M.leprae_Br4923          DVSEGNRIRIQAMLSEAARTWSDRLIAAAASFSEGSVSYAEAEHYAATFS
TH_0917|M.thermoresistible__bu      --------------------------------------------------
MAB_1561|M.abscessus_ATCC_1997      DTSEANRVRIQGLLTQTTRTWSDRLVRAVRPDS--PIDRACAERYSVILP
                                                                                      

Mflv_2569|M.gilvum_PYR-GCK          EVYKQANTPARALDDIAIIEELHDNTVKLVLADSDDTETSGVSDLNWYLG
Mvan_4069|M.vanbaalenii_PYR-1       EVYKQAIDPVHALADIAVIEELQDNSVKLVLADSDDTAESGVSHLNWYLG
MSMEG_4699|M.smegmatis_MC2_155      EDYKQAFAPQDAIADISLIEALQDDSVKLVLAD---TAEDRVWKLTWYLG
Rv2476c|M.tuberculosis_H37Rv        EAYKQAVTPADAIGDIAVITELTDDSVKLVFSER---DEQGVAQLTWFLG
Mb2503c|M.bovis_AF2122/97           EAYKQAVTPADAIGDIAVITELTDDSVKLVFSER---DEQGVAQLTWFLG
MMAR_3829|M.marinum_M               EAYKQAVAPADAIDHIAIINELADDSVKLVFSDR---TADGVAQLTWFLG
MAV_1696|M.avium_104                EVYKQAISPADAIGHIAIIKELQDNSVKLVFTD----GEDGSAQLTWFLG
MLBr_01249|M.leprae_Br4923          ETYKQAVTPADAIDHIAIIKELADDSVKLVFFER---KADGFAQLTWFLG
TH_0917|M.thermoresistible__bu      --------------------------------------------------
MAB_1561|M.abscessus_ATCC_1997      EVFKQNVPPAEAIADIARIEGLQEDSIDLAYDAD----ELGTGVLSMYLG
                                                                                      

Mflv_2569|M.gilvum_PYR-GCK          GQSASLSRLLPMLQSMGVVVLEERPFTVTRPDGLPVWIYQFKVSPHRGIP
Mvan_4069|M.vanbaalenii_PYR-1       GRSASLSRLLPMLQSMGVVVLEERPFTVVRPDGLPVWIYQFKVSPHRGIP
MSMEG_4699|M.smegmatis_MC2_155      GHSASLSELLPMLQSMGVVVLEERPFTLRRTDGLPVWIYQFKISPHPSIP
Rv2476c|M.tuberculosis_H37Rv        GRTASLSQLLPMLQSMGVVVLEERPFSVTRPDGLPVWIYQFKISPHPTIP
Mb2503c|M.bovis_AF2122/97           GRTASLSQLLPMLQSMGVVVLEERPFSVTRPDGLPVWIYQFKISPHPTIP
MMAR_3829|M.marinum_M               GCTASLSQLLPMLQSMGVVVLEERPFTVTRPDGLPVWIYQFKISPHPTIP
MAV_1696|M.avium_104                GRTASLSQLLPMLQSMGVVVLEERPFTVTRSDGLPVWIYQFRISPHPTIE
MLBr_01249|M.leprae_Br4923          GRSASLSQLLPMLQSMGVVVLEERPFTVARTDGLPVWIYQFKISPHPTIP
TH_0917|M.thermoresistible__bu      --------------------------------------------------
MAB_1561|M.abscessus_ATCC_1997      GRSASLSQVLPVLHSMGVDVLEERPYHFTRPDGLAVSLYAFRIVVHPAIA
                                                                                      

Mflv_2569|M.gilvum_PYR-GCK          QAPPGPERDATAERFADTVTAIWHGNAEIDRFNELVLRAGLTWQQVAVLR
Mvan_4069|M.vanbaalenii_PYR-1       EAPPGPQREATAERFADAVTAIWHGNAEIDRFNELVLRAELTWQQVAVLR
MSMEG_4699|M.smegmatis_MC2_155      HAPDAEAQRDTAQRFADAVTAIWHGRVEIDRFNELVMRAGLTWQQVVVLR
Rv2476c|M.tuberculosis_H37Rv        LAPTVAERAATAHRFAEAVTAIWHGRVEIDRFNELVMRAGLTWQQVVLLR
Mb2503c|M.bovis_AF2122/97           LAPTVAERAATAHRFAEAVTAIWHGRVEIDRFNELVMRAGLTWQQVVLLR
MMAR_3829|M.marinum_M               KATVPAERAAAAQRFADAVTAIWQGRIEIDRFNELVMRAGLTWQQVVLLR
MAV_1696|M.avium_104                LASTPDERDAMAERFADAVTAIWQGRLEVDRFNELVMRAGLRWQQVVLLR
MLBr_01249|M.leprae_Br4923          LASTANERELTAKRFSDAVTAIWQGRVEIDRFNELVMRARLTWQQVVLLR
TH_0917|M.thermoresistible__bu      --------------------------------------------------
MAB_1561|M.abscessus_ATCC_1997      RTFDAEGTARRADLLTRAIDAVWHGRVETDRFNELVLRAGLTAGQITILR
                                                                                      

Mflv_2569|M.gilvum_PYR-GCK          AYAKYLKQAGFPYSQSHIASVLNDNAGTARSLVELFEALYSPVDGNPGGA
Mvan_4069|M.vanbaalenii_PYR-1       AYARYLKQAGFAYSQSHIESVLNDNAGTARSLIALFEALFRPVEQGPG-A
MSMEG_4699|M.smegmatis_MC2_155      AYAKYLRQAGFPYSQSHIESVLNENPHTTRSLIDLFEALFDPSQETDG--
Rv2476c|M.tuberculosis_H37Rv        AYAKYLRQAGFPYSQSYIESVLNEHPATVRSLVDLFEALFVP-VPSGSAS
Mb2503c|M.bovis_AF2122/97           AYAKYLRQAGFPYSQSYIESVLNEHPATVRSLVDLFEALFVP-VPSGSAS
MMAR_3829|M.marinum_M               AYSRYLRQAGFPYSQSYIESVLNEHPSTARSLVLLFEALFDP-RPAGSPV
MAV_1696|M.avium_104                AYAKYLRQANFPYSQSYIEAVLNEHPSTARSLVALFEALFDP-DPD-SSA
MLBr_01249|M.leprae_Br4923          AYAKYLRQAGFNYSQSYIESVLNEHPSTARSLVALFEALFDP-SPLSSST
TH_0917|M.thermoresistible__bu      --------------------------------------------------
MAB_1561|M.abscessus_ATCC_1997      GYAKYLRQAGFPYSQAHIETVLADNSQTARDFVELFEARFDP----ESTD
                                                                                      

Mflv_2569|M.gilvum_PYR-GCK          NRDAQSAAAAVAADIDALVSLDTDRVLRAFASMIQATLRTNYFVTAADSA
Mvan_4069|M.vanbaalenii_PYR-1       NRDAQAAAAAVAADIDALVSLDTDRVLRAFASMIQATLRTNYFITGQESA
MSMEG_4699|M.smegmatis_MC2_155      RRDAQGAAAAVAADIDALVSLDTDRVLRAFANLIEATLRTNYFVARPDSA
Rv2476c|M.tuberculosis_H37Rv        NRDAQAAAAAVAADIDALVSLDTDRILRAFASLVQATLRTNYFVTRQGSA
Mb2503c|M.bovis_AF2122/97           NRDAQAAAAAVAADIDALVSLDTDRILRAFASLVQATLRTNYFVTRQGSA
MMAR_3829|M.marinum_M               SPDAQAAAAAVAADIDALVSLDTDRILRAFASLVQATLRTNYFVSREGSA
MAV_1696|M.avium_104                GRDAQAAAAAVAADIDALVSLDTDRILRAFASLVQATLRTNYFVTREGSA
MLBr_01249|M.leprae_Br4923          NCDAQAAAAAVAADIDALVSLDTDRILRAFASLVQATLRTNYFVTQKFSA
TH_0917|M.thermoresistible__bu      -----------------VVSLDTDRVLRAFASLIEATLRTNYFVSRDDSD
MAB_1561|M.abscessus_ATCC_1997      DTIADAKAAQVLAEIDKVVSLDTDRVLRAFFGLIQATLRTNYFVKKEDSA
                                                     :*******:**** .:::********:    * 

Mflv_2569|M.gilvum_PYR-GCK          RARNVLSFKLNPELIDELPLPRPKFEIFVYSPRVEGVHLRFGFVARGGLR
Mvan_4069|M.vanbaalenii_PYR-1       RARNVLSLKLNPQLIDELPLPRPKFEIFVYSPRVEGVHLRFGFVARGGLR
MSMEG_4699|M.smegmatis_MC2_155      RARNVLAFKLNPLVIKELPLPRPKFEIFVYSPRVEGVHLRFGFVARGGLR
Rv2476c|M.tuberculosis_H37Rv        RCRDVLALKLNAQLIDELPLPRPRYEIFVYSPRVEGVHLRFGPVARGGLR
Mb2503c|M.bovis_AF2122/97           RCRDVLALKLNAQLIDELPLPRPRYEIFVYSPRVEGVHLRFGPVARGGLR
MMAR_3829|M.marinum_M               RSRDVLSVKLDAQLIDELPLPRPKYEIFVYSPRVEGVHLRFGPVARGGLR
MAV_1696|M.avium_104                RARNVLVIKLDAQLIDELPLPRPKYEIFVYSPRVEGVHLRFGPVARGGLR
MLBr_01249|M.leprae_Br4923          RSKGVLVLKLDAQLINELPLPRPKFEIFVYSPRVEGVHLRFGAVARGGLR
TH_0917|M.thermoresistible__bu      RARGVFSVKLRPALIKELPLPRPMFEIFVYSPRVEGVHLRFGHVARGGLR
MAB_1561|M.abscessus_ATCC_1997      RAKGVLSFKLNPREIAELPEPRPRFEIFVYSPRVEGVHLRFGPVARGGLR
                                    *.:.*: .** .  * *** *** :***************** *******

Mflv_2569|M.gilvum_PYR-GCK          WSDRREDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKKPPAPTGDAAAD
Mvan_4069|M.vanbaalenii_PYR-1       WSDRREDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKHPPAPTGDAAAD
MSMEG_4699|M.smegmatis_MC2_155      WSDRREDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPTLTGDAAAD
Rv2476c|M.tuberculosis_H37Rv        WSDRRDDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPLPTGDPAAD
Mb2503c|M.bovis_AF2122/97           WSDRRDDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPLPTGDPAAD
MMAR_3829|M.marinum_M               WSDRRDDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPLSTGDAATD
MAV_1696|M.avium_104                WSDRRDDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPLPSGDGAAD
MLBr_01249|M.leprae_Br4923          WSDRLDDFRTEILGLVKAQAVKNAVIVPVGAKGGFVLKRPPLPTGDAAAD
TH_0917|M.thermoresistible__bu      WSDRREDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPAPTGDAAAD
MAB_1561|M.abscessus_ATCC_1997      WSDRREDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKNPPAVTGDAAAD
                                    **** :******************************:*.**  :** *:*

Mflv_2569|M.gilvum_PYR-GCK          RDATREEGVACYRLFIAGLLDITDNVDKISGDVVTPAEVVRRDGDDAYLV
Mvan_4069|M.vanbaalenii_PYR-1       RDATREEGVACYRLFIAGLLDITDNVDKVTGGIVAPADVVRRDGDDAYLV
MSMEG_4699|M.smegmatis_MC2_155      REATRAEGVECYRLFISGLLDVTDNVDKATGAVVTPPEVVRRDGEDAYLV
Rv2476c|M.tuberculosis_H37Rv        RDATRAEGVACYQLFISGLLDVTDNVDHATASVNPPPEVVRRDGDDAYLV
Mb2503c|M.bovis_AF2122/97           RDATRAEGVACYQLFISGLLDVTDNVDHATASVNPPPEVVRRDGDDAYLV
MMAR_3829|M.marinum_M               REATRAEGVACYQLFISGLLDVTDNVDHTTGVVSPPPEVLRRDGDDAYLV
MAV_1696|M.avium_104                RDATRAEGVACYQLFISGLLDVTDNVDHATGKVSPPPEVVRRDGDDAYLV
MLBr_01249|M.leprae_Br4923          RDAMRAEGIACYQLFISGLLDITDNVDHATGKVNAPPQVVRRDSDDAYLV
TH_0917|M.thermoresistible__bu      REAARAEGIACYRLFVSGLLDITDNVDKTTGAVVPPAEVVRRDGDDAYLV
MAB_1561|M.abscessus_ATCC_1997      RDAFRAEGVECYRRFISGLLDITDNRDRTTNAVVPPEGVRRRDGDDPYLV
                                    *:* * **: **: *::****:*** *: :  : .*  * ***.:*.***

Mflv_2569|M.gilvum_PYR-GCK          VAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITAKGAW
Mvan_4069|M.vanbaalenii_PYR-1       VAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITAKGAW
MSMEG_4699|M.smegmatis_MC2_155      VAADKGTATFSDIANEVAKSYGFWLGDAFASGGSIGYDHKAMGITAKGAW
Rv2476c|M.tuberculosis_H37Rv        VAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITARGAW
Mb2503c|M.bovis_AF2122/97           VAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITARGAW
MMAR_3829|M.marinum_M               VAADKGTATFSDIANEVANSYGFWLGDAFASGGSVGYDHKAMGITAKGAW
MAV_1696|M.avium_104                VAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITARGAW
MLBr_01249|M.leprae_Br4923          VAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITAKGAW
TH_0917|M.thermoresistible__bu      VAADKGTATFSDIANEVAQSYGFWLGDAFASGGSVGYDHKAMGITARGAW
MAB_1561|M.abscessus_ATCC_1997      VAADKGTATFSDIANDVALSYGFWLGDAFASGGSVGYDHKAMGITARGAW
                                    ***************:** ***************:***********:***

Mflv_2569|M.gilvum_PYR-GCK          ESVKRHFREMGIDTQSEDFTVVGVGDMSGDVFGNGMLLSEHIRLLAAFDH
Mvan_4069|M.vanbaalenii_PYR-1       ESVKRHFREMGVDTQSEDFTVVGVGDMSGDVFGNGMLLSKHIRLLAAFDH
MSMEG_4699|M.smegmatis_MC2_155      ESVKRHFREMGVDTQTQDFTVVGIGDMSGDVFGNGMLLSKHIRLVAAFDH
Rv2476c|M.tuberculosis_H37Rv        EAVKRHFREIGIDTQTQDFTVVGIGDMSGDVFGNGMLLSKHIRLIAAFDH
Mb2503c|M.bovis_AF2122/97           EAVKRHFREIGIDTQTQDFTVVGIGDMSGDVFGNGMLLSKHIRLIAAFDH
MMAR_3829|M.marinum_M               EAVKRHFREMGIDTQTEDFTVVGVGDMSGDVFGNGMLLSKHIRLIAAFDH
MAV_1696|M.avium_104                EAVKRHFREMGVDTQTEDFTVVGIGDMSGDVFGNGMLLSKHIRLLAAFDH
MLBr_01249|M.leprae_Br4923          EAVKRHFREMGVDTQNEDFTVVGIGDMSGDVFGNGMLLSKHIRLIAAFDH
TH_0917|M.thermoresistible__bu      ESVKRHFREMGVDTQTQDFTVVGIGDMSGDVFGNGMLLSKHIRLVAAFDH
MAB_1561|M.abscessus_ATCC_1997      ESVKRHFLEIGIDTQTQDFTVVGVGDMSGDVFGNGMLLSQHIKLVAAFDH
                                    *:***** *:*:***.:******:***************:**:*:*****

Mflv_2569|M.gilvum_PYR-GCK          RHIFIDPTPDAASSYAERRRLFDLPRSSWDDYDKSLISAGGGVYSREQKS
Mvan_4069|M.vanbaalenii_PYR-1       RHIFIDPTPDAASSWEERKRLFELPRSSWEDYDTSLISPGGGVYSREQKS
MSMEG_4699|M.smegmatis_MC2_155      RDIFLDPNPDAGRSWDERKRLFDLPRSSWADYDKSLISEGGGVYSRQQKS
Rv2476c|M.tuberculosis_H37Rv        RHIFLDPNPDAAVSWAERRRMFELPRSSWSDYDRSLISEGGGVYSREQKA
Mb2503c|M.bovis_AF2122/97           RHIFLDPNPDAAVSWAERRRMFELPRSSWGDYDRSLISEGGGVYSREQKA
MMAR_3829|M.marinum_M               RHVFLDPNPDAAASWQERQRMFDLPRSSWDDYNKSLISEGGGVYSREQKS
MAV_1696|M.avium_104                RHIFLDPNPDAAASWEERRRMFELPRSSWDDYDKSLISEGGGVYSREHKS
MLBr_01249|M.leprae_Br4923          RHVFLDPDPDAAVSWAERQRMFDLPRSSWDDYNKSLISEGGGVYSREQKA
TH_0917|M.thermoresistible__bu      RHIFLDPDPDPARSWEERKRLFELPRSSWDDYDTSVISRGGGVYSRQQKS
MAB_1561|M.abscessus_ATCC_1997      RHIFLDPNPDPASSWAERKRMFALERSSWADYNSALISAGGGVYSKEQKS
                                    *.:*:** **.. *: **:*:* * **** **: ::** ******:::*:

Mflv_2569|M.gilvum_PYR-GCK          IPISDEARAALGIEGDAT----EMTPPALMKAILKAPADLLWNGGIGTYI
Mvan_4069|M.vanbaalenii_PYR-1       IPVSAQARAALGLDDQVT----DLTPPALMKAILKAPADLLWNGGIGTYV
MSMEG_4699|M.smegmatis_MC2_155      IPISPQVRTALGLDADVE----ELTPPALIKAILKAPVDLLWNGGIGTYI
Rv2476c|M.tuberculosis_H37Rv        IPLSAQVRAVLGIDGSVDGGAAEMAPPNLIRAILRAPVDLLFNGGIGTYI
Mb2503c|M.bovis_AF2122/97           IPLSAQVRAVLGIDGSVDGGAAEMAPPNLIRAILRAPVDLLFNGGIGTYI
MMAR_3829|M.marinum_M               IPVSDQVRNALGIGGDVT----EMTPPNLIRAILQAPVDLLFNGGIGTYI
MAV_1696|M.avium_104                IPVSPQVRDALGLDGSGGGVVTEMTPPNLIKAILQAPVDLLFNGGIGTYI
MLBr_01249|M.leprae_Br4923          IPTSPQVRTALGIDGEVT----EMAPPNLIRAILQAPVDLLFNGGIGTYI
TH_0917|M.thermoresistible__bu      IPVSAEVRAALGLDGDVD----ALTPPAMIRAILRAPVDLLFNGGIGTYI
MAB_1561|M.abscessus_ATCC_1997      IPISPEVRDVLGLDSDVV----EMTPPQLVRAILLAPVDLFFNGGIGTYV
                                    ** * :.* .**:  .       ::** :::*** **.**::*******:

Mflv_2569|M.gilvum_PYR-GCK          KAETEADADVGDRANDPVRVNGNQVRAKVVGEGGNLGVTSLGRTEFDLCG
Mvan_4069|M.vanbaalenii_PYR-1       KAETEADADVGDRANDAVRVNGNEVRAKVIGEGGNLGVTSRGRTEFDLCG
MSMEG_4699|M.smegmatis_MC2_155      KAETEADADVGDRANDQIRVCGNQVRAKVIGEGGNLGVTALGRIEFDLAG
Rv2476c|M.tuberculosis_H37Rv        KAESESDADVGDRANDPVRVNANQVRAKVIGEGGNLGVTALGRVEFDLSG
Mb2503c|M.bovis_AF2122/97           KAESESDADVGDRANDPVRVNANQVRAKVIGEGGNLGVTALGRVEFDLSG
MMAR_3829|M.marinum_M               KAESESDADVGDRANNPVRVNANQVRAKVIGEGGNLGVTALGRVEFDLSG
MAV_1696|M.avium_104                KAESESDADVGDRANDPVRVNGSSVRAKVIGEGGNLGVTALGRVEFDLSG
MLBr_01249|M.leprae_Br4923          KAETESVADVGDRANDPVRVNANQVRAKVIGEGGNLGVTALGRVEFDLSG
TH_0917|M.thermoresistible__bu      KAESESDADVGDRANDPVRVNGNQVRAKVIGEGGNLGVTPLGRVEYDLAG
MAB_1561|M.abscessus_ATCC_1997      KAESESQADVGDKANDAVRVNGNQVRAKVIGEGGNLGLTSRGRIEFELNG
                                    ***:*: *****:**: :** ...*****:*******:*. ** *::* *

Mflv_2569|M.gilvum_PYR-GCK          GRINTDAMDNSAGVDCSDHEVNIKILIDSLVTAGKVAEADRTELLLSMTD
Mvan_4069|M.vanbaalenii_PYR-1       GRINTDAMDNSAGVDCSDHEVNIKILIDSLVTAGKVEESGRSALLSSMTD
MSMEG_4699|M.smegmatis_MC2_155      GRINTDALDNSAGVDCSDHEVNIKILIDSAVTAGKVTPEERTELLLSMTD
Rv2476c|M.tuberculosis_H37Rv        GRINTDALDNSAGVDCSDHEVNIKILIDSLVSAGTVKADERTQLLESMTD
Mb2503c|M.bovis_AF2122/97           GRINTDALDNSAGVDCSDHEVNIKILIDSLVSAGTVKADERTQLLESMTD
MMAR_3829|M.marinum_M               GRINTDALDNSAGVDCSDHEVNIKILIDSLVSAGKVRTDERKQLLESMTD
MAV_1696|M.avium_104                GRINTDAMDNSAGVDCSDHEVNIKILIDSLVTAGKVKPQERKPLLESMTD
MLBr_01249|M.leprae_Br4923          GRINTDAMDNSAGVDCSDHEVNIKILIDSLVTAGKVKVEERKHLLESMTD
TH_0917|M.thermoresistible__bu      GRINTDALDNSAGVDCSDHEVNIKILIDSLVAAGKIGADQRTDLLMSMTD
MAB_1561|M.abscessus_ATCC_1997      GRVNTDALDNSAGVDCSDHEVNIKILIDSLVSAGKIEASERTALLESMTD
                                    **:****:********************* *:**.:    *. ** ****

Mflv_2569|M.gilvum_PYR-GCK          EVGRLVLADNESQNDLMGTSRANAASLLNVHARMIKDFVERRGLNRELEA
Mvan_4069|M.vanbaalenii_PYR-1       EVGRLVLADNESQNDLMGTSRANAASLLNVHGRMIRSFVEERGLNRELEA
MSMEG_4699|M.smegmatis_MC2_155      EVGELVLADNRDQNDLMGTSRANAASLLSVHARMIKDLVDNRGLNRELEA
Rv2476c|M.tuberculosis_H37Rv        EVAQLVLADNEDQNDLMGTSRANAASLLPVHAMQIKYLVAERGVNRELEA
Mb2503c|M.bovis_AF2122/97           EVAQLVLADNEDQNDLMGTSRANAASLLPVHAMQIKYLVAERGVNRELEA
MMAR_3829|M.marinum_M               EVAQLVLTDNSDQNDLMGTSRANPVSLLPVHADQIRYLVAERGISRELEA
MAV_1696|M.avium_104                EVAALVLTDNEDQNDLIGTSRANAPSLLPVHARQIQYLVDERGLNRELEA
MLBr_01249|M.leprae_Br4923          EVARLVLTDNEDQNDLIGTSRANAANMLSVHAMQIKYLVDERGVNRELEA
TH_0917|M.thermoresistible__bu      EVADMVLAHNARQNDLIGTSRANTAAMLTVHARLIDDLVENHGVNRELEA
MAB_1561|M.abscessus_ATCC_1997      DVATLVLADNESQNNLMGTSRANAASLLSVHARQIAYLVNERGLDRELEA
                                    :*. :**:.*  **:*:******.  :* **.  *  :* .:*:.*****

Mflv_2569|M.gilvum_PYR-GCK          LPSEKEILRRTEAGLGLTSPELATLMAHVKLALKDDLLAGELPDQEVFAS
Mvan_4069|M.vanbaalenii_PYR-1       LPSEKEIRRREEAGIGLTSPELATLMAHVKLALKDDLLAGDLPDQEVFAS
MSMEG_4699|M.smegmatis_MC2_155      LPSEKEIRRRADAGIGLTSPELATLMAHVKLALKDDVLASDLPDQEVFAS
Rv2476c|M.tuberculosis_H37Rv        LPSEKEIARRSEAGIGLTSPELATLMAHVKLGLKEEVLATELPDQDVFAS
Mb2503c|M.bovis_AF2122/97           LPSEKEIARRSEAGIGLTSPELATLMAHVKLGLKEEVLATELPDQDVFAS
MMAR_3829|M.marinum_M               LPSEKEIARRSEAGIGLTSPELATLMAHVKLALKETMLTTELPDQDVFAS
MAV_1696|M.avium_104                LPSEKEIQRRAEAGIGLTSPELCTLMAHVKLDLKEQMLQTELTEQDVFAS
MLBr_01249|M.leprae_Br4923          LPSEKEIQRRSEAGIGLTSPELSTLMAHVKLALKEQMLATELPDQDVFVS
TH_0917|M.thermoresistible__bu      LPSDKEIARRSDTGVGLTSPELATVMAHVKLTLKDALLASELPDQEVFAA
MAB_1561|M.abscessus_ATCC_1997      LPSEKEIDRRAALGIGLTSPELATLMAHVKLGLKDDLLASDAPDQEVTLR
                                    ***:*** **   *:*******.*:****** **: :*  : .:*:*   

Mflv_2569|M.gilvum_PYR-GCK          RLPSYFPTTLRERFGPDIRSHQLRREIVTTMLVNDVVDTAGISYAYRVAE
Mvan_4069|M.vanbaalenii_PYR-1       RLPSYFPATLRDQFSPEIRAHQLRREIVTTMLVNDVVDTAGISYAYRVTE
MSMEG_4699|M.smegmatis_MC2_155      RLPYYFPTRLREELHGEIRSHQLRREIITTMLVNDLVDTAGISYAYRITE
Rv2476c|M.tuberculosis_H37Rv        RLPRYFPTALRERFTPEIRSHQLRREIVTTMLINDLVDTAGITYAFRIAE
Mb2503c|M.bovis_AF2122/97           RLPRYFPTALRERFTPEIRSHQLRREIVTTMLINDLVDTAGITYAFRIAE
MMAR_3829|M.marinum_M               RLPSYFPKPLRERFAPEIRSHQLRREIVTTMVINDLVDTAGITYAFRITE
MAV_1696|M.avium_104                RLPLYFPTPLRHRFTPEIRAHQLRREIVATMLINELVDAAGISYAFRIVE
MLBr_01249|M.leprae_Br4923          RLPRYFPKPLRERFTPEIRSHQLRREIVTTMLINDLVDTAGISYAFRIAE
TH_0917|M.thermoresistible__bu      RLPSYFPRPLRD-FTAEIRGHQLRREIVSTMLVNDLVDTAGLTYAFRVCE
MAB_1561|M.abscessus_ATCC_1997      RMVHYFPDVLRERFDAEIRQHPLRKEIYATMLVNSVVDCGGITYVYRLFE
                                    *:  ***  **. :  :** * **:** :**::*.:** .*::*.:*: *

Mflv_2569|M.gilvum_PYR-GCK          DVGVAPIDAVRSFAAGDAIFGFGRVWRQIREAGAN-GVSVAVTDRMTLDL
Mvan_4069|M.vanbaalenii_PYR-1       DVGVAPVDAVRSFVAADAIFGVGRVWRQIREAGAN-GVPVAVTDRMTLDL
MSMEG_4699|M.smegmatis_MC2_155      DVGVGPVDAVRSYVAINAIFGIGDVWRRIRAAGDA-GVPTSVTDRMTLDL
Rv2476c|M.tuberculosis_H37Rv        DVGVTPIDAVRTYVATDAIFGVGHIWRRIRAA----NLPIALSDRLTLDT
Mb2503c|M.bovis_AF2122/97           DVGVTPIDAVRTYVATDAIFGVGHIWRRIRAA----NLPIALSDRLTLDT
MMAR_3829|M.marinum_M               DVGVSPIDAVRTYMATDAIFGVSHIWRRIRAE----ELPVALSDRLTLDT
MAV_1696|M.avium_104                DVGVSAVDAVRTYVATDAIFGVGEIWRRIRAA----NLPVALSDRLTLDT
MLBr_01249|M.leprae_Br4923          DIGVGPIDAIRTYVATDAIFGVGDVLRRIRAA----NLSVVLSDRMTLDT
TH_0917|M.thermoresistible__bu      DAGVEPVDAVRSFVAVDAIFRVGEIWHAIRTAGAEGVLPVAVSDRMTLDL
MAB_1561|M.abscessus_ATCC_1997      DAGTGSVDGLKTYVAVEAIFGLRSLWDRIRHA----DVPVAVSDRLTLDM
                                    * *. .:*.:::: * :*** .  :   **       :.  ::**:*** 

Mflv_2569|M.gilvum_PYR-GCK          RRLIDRATRWLLNYRPLPLAVGAEINRFADKVAALTPSMPDWLRGDDKAI
Mvan_4069|M.vanbaalenii_PYR-1       RRLIDRAARWLLNYRPQPLAVGAEINRFADKVAALTPRMPDWLRGDDKAI
MSMEG_4699|M.smegmatis_MC2_155      RRLVDRAGRWLLNYRPQPLAVGAEINRFGAKVAALTPRMSEWLRGDDKAI
Rv2476c|M.tuberculosis_H37Rv        RRLIDRAGRWLLNYRPQPLAVGAEINRFAAMVKALTPRMSEWLRGDDKAI
Mb2503c|M.bovis_AF2122/97           RRLIDRAGRWLLNYRPQPLAVGAEINRFAAMVKALTPRMSEWLRGDDKAI
MMAR_3829|M.marinum_M               RRLIDRASRWLLNYRPQPLAVGAEINRFAAKVKALTPRMSEWLRGDDKAI
MAV_1696|M.avium_104                RRLIDRAGRWLLNYRPQPLAVGAEINRFAAKVKALTPRMSEWLRGDDKAI
MLBr_01249|M.leprae_Br4923          RRLIDRAGRWLLNYRPQPLAVGAEINRFAAKVKALTPRMSEWLRGDDQAI
TH_0917|M.thermoresistible__bu      RRLIDRAARWLLNFRPQPLAVGAEINRFAAKVAALTPRMSEWLCGADADI
MAB_1561|M.abscessus_ATCC_1997      RRLLDRASRWLISYRPQPLAVGAEINRFAEGIAELSPKLTTWLRGHDLEI
                                    ***:*** ***:.:** ***********.  :  *:* :. ** * *  *

Mflv_2569|M.gilvum_PYR-GCK          VEKEAGEFSAHGVAEDVAYTVATGLYQFSLLDVIDIADIIDRDPAEVADA
Mvan_4069|M.vanbaalenii_PYR-1       VAKEAAEFSSQGVPDDVAYMVASGLYQFSLLDVIDIADIVDRDPAEVADA
MSMEG_4699|M.smegmatis_MC2_155      VSKEAGDFASHGVPEDLAYHIATGLYQYSLLDVIDIADIVDREPDEVADT
Rv2476c|M.tuberculosis_H37Rv        VEKTAAEFASQGVPEDLAYRVSTGLYRYSLLDIIDIADIADIDAAEVADT
Mb2503c|M.bovis_AF2122/97           VEKTAAEFASQGVPEDLAYRVSTGLYRYSLLDIIDIADIADIDAAEVADT
MMAR_3829|M.marinum_M               VEKTSEEFIAQGAPEDLAYRVAVGLYRYSLLDIIDIADIADIDAAEVADT
MAV_1696|M.avium_104                VEKEAAEFESQGAPRDLAYLVAAGLYRFSLLDIIDIGDINDIDAAEVADT
MLBr_01249|M.leprae_Br4923          VEQQATEFVSQGAPEDLAYRVAVGLYRYSLLDIIDIADITELDPAEVADT
TH_0917|M.thermoresistible__bu      VARRTADFVEHGASRQLAYLVSSALYQFSLLDIIDIADILDREPAEVAET
MAB_1561|M.abscessus_ATCC_1997      VTKQTEDLVALGVPFDLASDVASCLYGFSLLDIIDIADIADRDGAEVADL
                                    * : : ::   *.. ::*  ::  ** :****:***.** : :  ***: 

Mflv_2569|M.gilvum_PYR-GCK          YFALMDHLGTDGLLTAVSRLSRNDRWHSLARLAIRDDIYGSLRALCFDVL
Mvan_4069|M.vanbaalenii_PYR-1       YFALMDHLGTDGLLTAVSRLSRYDRWHSLARLAIRDDIYGSLRALCFDVL
MSMEG_4699|M.smegmatis_MC2_155      YFALMDHLGADALLTAVSRLSRDDRWHSLARLAIRDDIYGSLRALCFDVL
Rv2476c|M.tuberculosis_H37Rv        YFALMDRLGTDGLLTAVSQLPRHDRWHSLARLAIRDDIYGALRSLCFDVL
Mb2503c|M.bovis_AF2122/97           YFALMDRLGTDGLLTAVSQLPRHDRWHSLARLAIRDDIYGALRSLCFDVL
MMAR_3829|M.marinum_M               YFALVDRLGADGLLTAVSELPRKDRWHSLARLAIRDDIYGALRSLCFDVI
MAV_1696|M.avium_104                YFALMDRLGTDGLLTAVSELPRNDRWHSLARLAICDDIYASLRSLCFDVL
MLBr_01249|M.leprae_Br4923          YFSLMDRLGTDGLLTAVSKLPQNDRWHSLARLAIRDDIYASLRSLCFDVL
TH_0917|M.thermoresistible__bu      YFALMGHLNADALLTAVSELPRSDRWHSLARLAIRDDIYGSLRLLTVDVL
MAB_1561|M.abscessus_ATCC_1997      YFTLMDDLRVDDLLTAVSQLERNDRWHSLARLAIRDDIYSSLRALTMDVL
                                    **:*:. * .* ******.* : *********** ****.:** * .**:

Mflv_2569|M.gilvum_PYR-GCK          AVGEPDENGVEKIAEWEMTNRSRISRARRTLTELYESGEHDLATLSVAAR
Mvan_4069|M.vanbaalenii_PYR-1       AVGEPDEDGVEKIAEWETTNSSRVSRARRTLAELYESGEHDLATLSVAAR
MSMEG_4699|M.smegmatis_MC2_155      AVGEPDENGEEKIAEWETTNSSRVTRARRTLTEIYKDGEQDLATLSVAAR
Rv2476c|M.tuberculosis_H37Rv        AVGEPGESSEQKIAEWEHLSASRVARARRTLDDIRASGQKDLATLSVAAR
Mb2503c|M.bovis_AF2122/97           AVGEPGESSEQKIAEWEHLSASRVARARRTLDDIRASGQKDLATLSVAAR
MMAR_3829|M.marinum_M               AVGEPDESSEQKILEWEQLSASRVDRARRTLNEIRDSGQKDLATLSVAAR
MAV_1696|M.avium_104                AVGEPDESGEEKIAEWEHLSASRVERARRTLIEIQESGAKDLATLSVAAR
MLBr_01249|M.leprae_Br4923          AVGEPDESGEEKIAEWEHISASRVERARLMLAEIHASGEKDLATLSVAAR
TH_0917|M.thermoresistible__bu      AVGEPDESGEEKIAEWESTNSSRLRRARRTLDEIYQDDIRDLATLSVAAR
MAB_1561|M.abscessus_ATCC_1997      SVGEPDETGEQKIAEWEFTNASRLERARGTLAEIFAAGEPDLATLSVAAR
                                    :****.* . :** ***  . **: ***  * ::   .  **********

Mflv_2569|M.gilvum_PYR-GCK          QIRSMTRTSGTGSSG
Mvan_4069|M.vanbaalenii_PYR-1       QIRSMTRTSGTGSSG
MSMEG_4699|M.smegmatis_MC2_155      QIRSMTRTSGTGTTG
Rv2476c|M.tuberculosis_H37Rv        QIRRMTRTSGRGISG
Mb2503c|M.bovis_AF2122/97           QIRRMTRTSGRGISG
MMAR_3829|M.marinum_M               QVRRMTRTSGRGISG
MAV_1696|M.avium_104                QIRRMTRTSGRGSSS
MLBr_01249|M.leprae_Br4923          QIRRMTRTSGRGSSG
TH_0917|M.thermoresistible__bu      QIRAMTRTSGTGSSA
MAB_1561|M.abscessus_ATCC_1997      QIRGMIRSSITGPA-
                                    *:* * *:*  * :