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SLNPGAINGSVGPEVSSEVIDRLLPAYLATYRGPHGGAPGAESAVTGPLRRQGTDTVNGPALVAAHYRLG AQRSPGATRVAVHAADVEGGFGPALQVVTDNAAILMDSITVLLHRIGVAYTAIMNPVFRVRRGAGGELQD IAPASDATFVDGVDETWVHVQLADSVDRRALAEAEELLPRVLADARQVALDSTGMAAALRTLAAELDSDP GRRFPSPDRKDVAALLRWLADGHFVLLGYQRCPVRDGEATVDPSSRLGVLRLREDVFPQLTNKDELLTLA QATIPSFLRYGTYPQIVVVREQSGDADADDAAAIEHRFVGMFTVAAMNANVLEIPLVSRRVNDALAMAHR DPSHPGQLVLDIIQTIPRSELFALSARGLLDMAMAVVDLGSRRRALLFMRADPLAHFVSCLVYLPRDRYT TAVRLEMQDILVRELGGVSIDYAARVSESPWAVVHFTVRMPEGSRPQDIDVSEPNESRIQDLLTEAARTW SDRLLGAVSAGGEVDQATAEHYASAFSEVYKQAIDPVHALADIAVIEELQDNSVKLVLADSDDTAESGVS HLNWYLGGRSASLSRLLPMLQSMGVVVLEERPFTVVRPDGLPVWIYQFKVSPHRGIPEAPPGPQREATAE RFADAVTAIWHGNAEIDRFNELVLRAELTWQQVAVLRAYARYLKQAGFAYSQSHIESVLNDNAGTARSLI ALFEALFRPVEQGPGANRDAQAAAAAVAADIDALVSLDTDRVLRAFASMIQATLRTNYFITGQESARARN VLSLKLNPQLIDELPLPRPKFEIFVYSPRVEGVHLRFGFVARGGLRWSDRREDFRTEILGLVKAQAVKNA VIVPVGAKGGFVVKHPPAPTGDAAADRDATREEGVACYRLFIAGLLDITDNVDKVTGGIVAPADVVRRDG DDAYLVVAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITAKGAWESVKRHFREMGVDT QSEDFTVVGVGDMSGDVFGNGMLLSKHIRLLAAFDHRHIFIDPTPDAASSWEERKRLFELPRSSWEDYDT SLISPGGGVYSREQKSIPVSAQARAALGLDDQVTDLTPPALMKAILKAPADLLWNGGIGTYVKAETEADA DVGDRANDAVRVNGNEVRAKVIGEGGNLGVTSRGRTEFDLCGGRINTDAMDNSAGVDCSDHEVNIKILID SLVTAGKVEESGRSALLSSMTDEVGRLVLADNESQNDLMGTSRANAASLLNVHGRMIRSFVEERGLNREL EALPSEKEIRRREEAGIGLTSPELATLMAHVKLALKDDLLAGDLPDQEVFASRLPSYFPATLRDQFSPEI RAHQLRREIVTTMLVNDVVDTAGISYAYRVTEDVGVAPVDAVRSFVAADAIFGVGRVWRQIREAGANGVP VAVTDRMTLDLRRLIDRAARWLLNYRPQPLAVGAEINRFADKVAALTPRMPDWLRGDDKAIVAKEAAEFS SQGVPDDVAYMVASGLYQFSLLDVIDIADIVDRDPAEVADAYFALMDHLGTDGLLTAVSRLSRYDRWHSL ARLAIRDDIYGSLRALCFDVLAVGEPDEDGVEKIAEWETTNSSRVSRARRTLAELYESGEHDLATLSVAA RQIRSMTRTSGTGSSG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_4069 | - | - | 100% (1627) | NAD-glutamate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2503c | gdh | 0.0 | 70.43% (1640) | NAD-dependent glutamate dehydrogenase |
M. gilvum PYR-GCK | Mflv_2569 | - | 0.0 | 87.71% (1628) | NAD-glutamate dehydrogenase |
M. tuberculosis H37Rv | Rv2476c | gdh | 0.0 | 70.43% (1640) | NAD-dependent glutamate dehydrogenase |
M. leprae Br4923 | MLBr_01249 | - | 0.0 | 69.32% (1636) | hypothetical protein MLBr_01249 |
M. abscessus ATCC 19977 | MAB_1561 | - | 0.0 | 64.62% (1566) | NAD-dependent glutamate dehydrogenase |
M. marinum M | MMAR_3829 | gdh | 0.0 | 69.85% (1632) | NAD-dependent glutamate dehydrogenase Gdh |
M. avium 104 | MAV_1696 | - | 0.0 | 72.09% (1605) | NAD-glutamate dehydrogenase |
M. smegmatis MC2 155 | MSMEG_4699 | - | 0.0 | 76.93% (1608) | NAD-glutamate dehydrogenase |
M. thermoresistible (build 8) | TH_0917 | - | 0.0 | 79.62% (893) | PROBABLE NAD-DEPENDENT GLUTAMATE DEHYDROGENASE GDH (NAD-GDH) |
M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment Mvan_4069|M.vanbaalenii_PYR-1 ---------------MSLNPGAIN---GSVGPEVSSEVIDRLLPAYLATY Mflv_2569|M.gilvum_PYR-GCK ---------------MSLNPGAVN---GATG-AVGAEMVERLIPAYLATY MSMEG_4699|M.smegmatis_MC2_155 -------------------------------------MIRRLSVAFLSTY Mb2503c|M.bovis_AF2122/97 ---------------MTIDPGAKQDVEAWTTFTASADIPDWISKAYIDSY Rv2476c|M.tuberculosis_H37Rv ---------------MTIDPGAKQDVEAWTTFTASADIPDWISKAYIDSY MMAR_3829|M.marinum_M ---------------MTIDPGAKQDVGAWTAFTQPADIPDWISQAYLDSY MAV_1696|M.avium_104 MFERIDNRRQLGAIGMTIDPRAQQDLKPWTTFTRQQDIPEWISKAYVESY MLBr_01249|M.leprae_Br4923 ---------------MTIDPGATHVAELCTTFTQGADVPDWISKAYIDSY TH_0917|M.thermoresistible__bu -------------------------------------------------- MAB_1561|M.abscessus_ATCC_1997 ---------------MTVNTGTTTSENTPSANGSGVPTIEALTAAFSGAR Mvan_4069|M.vanbaalenii_PYR-1 RGPHGGAPGAESAVTGPLRRQGTDTVNGPALVAAHYRLGAQRSPGATRVA Mflv_2569|M.gilvum_PYR-GCK RGPHGGAPGADAAVTGPLRRH-DDGLDTTALVEAQCRLAGTRLPGATNVA MSMEG_4699|M.smegmatis_MC2_155 RGPQADAPGVTS--TGPLAVAAHDDLVSDDLVAAHYRLASMRAPGETKAA Mb2503c|M.bovis_AF2122/97 -RGPRDDS--SEATKAAEASWLPASLLTPAMLGAHYRLGRHRAAGESCVA Rv2476c|M.tuberculosis_H37Rv -RGPRDDS--SEATKAAEASWLPASLLTPAMLGAHYRLGRHRAAGESCVA MMAR_3829|M.marinum_M QRRGEEDS--QASQRAAEA---AASVVTPAMLSAHYRLGQHRPIGESRVA MAV_1696|M.avium_104 RGPHSDES--GGAEAGPIDLTVPTAIVTPAMLSAHYRLGLHRPDGESRVA MLBr_01249|M.leprae_Br4923 RGSHGDVR--EAPETSRVN---PNALVTPAMLSAHYRLGQCRPNGRNCVR TH_0917|M.thermoresistible__bu -------------------------------------------------- MAB_1561|M.abscessus_ATCC_1997 YMGEMDWD---EPLEPDGHAAPAAPPVREALMRALLRLAARRQPHEIAMA Mvan_4069|M.vanbaalenii_PYR-1 VHAADVEGGFGPALQVVTDNAAILMDSITVLLHRIGVAYTAIMNPVFRVR Mflv_2569|M.gilvum_PYR-GCK VYPGDEATGFGPALQIVTDNASLLMDSVTVLLHRIGVAYTAIMNPGFRVR MSMEG_4699|M.smegmatis_MC2_155 VYPGDAGS--GAALQIVTDQAPMLVDSVTVLLHRHGIAYTAIMNPVFRVR Mb2503c|M.bovis_AF2122/97 VYRADDPAGFGPALQVVAEHGGMLMDSVTVLLHRLGIAYAAILTPVFDVH Rv2476c|M.tuberculosis_H37Rv VYRADDPAGFGPALQVVAEHGGMLMDSVTVLLHRLGIAYAAILTPVFDVH MMAR_3829|M.marinum_M VYPADDPVGFGPALQVVTEHGSMLMDSVTVLLHRLGVGYTTIMTPVFEVH MAV_1696|M.avium_104 VYPADDPAGFGPALQVVTDHGGMLMDSVTVLLHRLGVPYTAIMTPVFDVH MLBr_01249|M.leprae_Br4923 VYPADDPAGFGPALQIVTDHGGMVMDSITVLLHRLGVTYTAMMTPVFMVL TH_0917|M.thermoresistible__bu -------------------------------------------------- MAB_1561|M.abscessus_ATCC_1997 TYRNGDDAGLGTALQLVTDYTPLLTESITVLLRRQGVAIVDLMDPVFSVE Mvan_4069|M.vanbaalenii_PYR-1 RGAGGELQDIAPASDATFVD----GVDETWVHVQLADSVDRRALAEAEEL Mflv_2569|M.gilvum_PYR-GCK RGGAGELLDVAPVSDASFSD----GVDETWVHVQLAGSVDRHALAEAEEL MSMEG_4699|M.smegmatis_MC2_155 RGLDGELLDVRPAAEAAPGD----GADECWILVPITAAADGEALTEATRL Mb2503c|M.bovis_AF2122/97 RSPTGELLRIEPKAEGTSP-----HLGEAWMHVALSPAVDHKGLAEVERL Rv2476c|M.tuberculosis_H37Rv RSPTGELLRIEPKAEGTSP-----HLGEAWMHVALSPAVDHKGLAEVERL MMAR_3829|M.marinum_M RGPTGELQRVEPKSLDASP-----YVGEAWIHVQLSPTVEAKALAEVEQL MAV_1696|M.avium_104 RSPDGDLLSLEPKPQGAPQ-----YAGEAWIHVQLLPSVDSKGLTEAERL MLBr_01249|M.leprae_Br4923 RSPTGELLGVEPRASSTSHSIEGTWVGEVWIYIQLLPAVDSKSLAEVEQL TH_0917|M.thermoresistible__bu -------------------------------------------------- MAB_1561|M.abscessus_ATCC_1997 RAADGTLLSAAPVDHPQSDT---APNAECWIHLQLPPSIDAERLAFIETQ Mvan_4069|M.vanbaalenii_PYR-1 LPRVLADARQVALDSTGMAAALRTLAAELDSDPG-RRFPSPDRKDVAALL Mflv_2569|M.gilvum_PYR-GCK LPKVLADARQVALDSTDMAAALRILAAELDGDTG-RRFPSPDRKDVAALL MSMEG_4699|M.smegmatis_MC2_155 VPGILAEARQIGLDSGAMIAALHGLANDLATDLE-GHFPNAERKEVAALL Mb2503c|M.bovis_AF2122/97 LPKVLADVQRVATDATALIATLSELAGEVESNAG-GRFSAPDRQDVGELL Rv2476c|M.tuberculosis_H37Rv LPKVLADVQRVATDATALIATLSELAGEVESNAG-GRFSAPDRQDVGELL MMAR_3829|M.marinum_M LPKVLADVQRVAKDAPAMIATLSELAVAVDSDRE-GHYAAPDHQEVAALL MAV_1696|M.avium_104 LPKVLADVQQVASDASALIAVLDELAAAVEANRD-NHFSAPDRDDVAALL MLBr_01249|M.leprae_Br4923 LPRTLVDVQRVAADAAALNATLSGLAADVKTNKE-GHFSASDRDDVAALL TH_0917|M.thermoresistible__bu -------------------------------------------------- MAB_1561|M.abscessus_ATCC_1997 LPHTLEDGSHVAADTDAMRDAVIELASDLDAAPGNARFSSAELTEVANLL Mvan_4069|M.vanbaalenii_PYR-1 RWLADGHFVLLGYQRCPVRDGEATVDPSSRLGVLRLREDVFPQLTNKDEL Mflv_2569|M.gilvum_PYR-GCK RWLADGHFVLLGYQRCPVRDGEATVDTSSRLGVLRLRQDVLPQLTQKDEL MSMEG_4699|M.smegmatis_MC2_155 RWLADGHFVLLGYQQCVVGDGNAEVDPASRLGVLRLRNDVLPPLTDSDDL Mb2503c|M.bovis_AF2122/97 RWLGDGNFLLLGYQRCRVADGMVYGEGSSGMGVLRGRTGSRPRLTDDDKL Rv2476c|M.tuberculosis_H37Rv RWLGDGNFLLLGYQRCRVADGMVYGEGSSGMGVLRGRTGSRPRLTDDDKL MMAR_3829|M.marinum_M RWLGNGNFLLLGYQPCEVDDGMVLGDGSTGLGVLRARTGTRPRLTDETKL MAV_1696|M.avium_104 RWLGNGNFLLLGYQRCRVHDGLVSGDGSPGLGVLRTRTGSRPRLTDDDRL MLBr_01249|M.leprae_Br4923 HWLGNGNFLLLGYQRCRVHYGLVSCDRSTGLGVLRARTGSRPRLTDDNEL TH_0917|M.thermoresistible__bu -------------------------------------------------- MAB_1561|M.abscessus_ATCC_1997 RWLVDGNFTLLGYQRCTVENGHATVDESSRLGLLKRREEVLPQLTHNDQL Mvan_4069|M.vanbaalenii_PYR-1 LTLAQATIPSFLRYGTYPQIVVVREQSGDADADDAAAIEHRFVGMFTVAA Mflv_2569|M.gilvum_PYR-GCK LTLAQATIPSFLRYGAYPQIVVVREQSPERDAD---AIEHRFVGLFTVAA MSMEG_4699|M.smegmatis_MC2_155 LVLAQATMPSYLRYGAYPYIVVVRESPG---ASR--VIEHRFVGLFTVAA Mb2503c|M.bovis_AF2122/97 LVLAQARVGSYLRYGAYPYAIAVREYV---DGS---VVEHRFVGLFSVAA Rv2476c|M.tuberculosis_H37Rv LVLAQARVGSYLRYGAYPYAIAVREYV---DGS---VVEHRFVGLFSVAA MMAR_3829|M.marinum_M LVLAQARVGSYLRYGAYPYAIAIRESLG--DGN---IVEHRFVGLFTVAA MAV_1696|M.avium_104 LVLAQSVVGSYLRYGAYPYAIAVREYV---DGA---VIEHRFVGLFTVAA MLBr_01249|M.leprae_Br4923 LVLAQAAVGNYLRYGAYPYAIAVREYDDGGDGG---IIEHRFVGLFTVAA TH_0917|M.thermoresistible__bu -------------------------------------------------- MAB_1561|M.abscessus_ATCC_1997 LVLAQATTPTYLRYAIYPNIVVIRQDNG--SGP---AIEHRLVGVFTVAA Mvan_4069|M.vanbaalenii_PYR-1 MNANVLEIPLVSRRVNDALAMAHR-DPSHPGQLVLDIIQTIPRSELFALS Mflv_2569|M.gilvum_PYR-GCK MNANVLEIPLVSRRVNDALAMAHR-DPSHPGQLLLDIIQTIPRSELFALS MSMEG_4699|M.smegmatis_MC2_155 MNANALEIPLISRRVEEALAMAHR-DPSHPGQLLRDIIQTIPRPELFALS Mb2503c|M.bovis_AF2122/97 MNADVLEIPTISRRVREALAMAES-DPSHPGQLLLDVIQTVPRPELFTLS Rv2476c|M.tuberculosis_H37Rv MNADVLEIPTISRRVREALAMAES-DPSHPGQLLLDVIQTVPRPELFTLS MMAR_3829|M.marinum_M MNADVLEIPAISHRVRDALELAGN-DPSHPGQLLLDVIQTVPRPELFTLS MAV_1696|M.avium_104 MNADVLEIPTISRRVREALAMADS-DPIHPGQLLLDVIQTVPRSELFTLS MLBr_01249|M.leprae_Br4923 MNADVLEIPSISHRVRAALAMANS-DPIYPGQLLLDVIQTVPRSELFTLS TH_0917|M.thermoresistible__bu -------------------------------------------------- MAB_1561|M.abscessus_ATCC_1997 MNADVLAIPVVCDRVHQVLGRSDATQDSLAGHMLIEFMQNLPRAELFASS Mvan_4069|M.vanbaalenii_PYR-1 ARGLLDMAMAVVDLGSRRRALLFMRADPLAHFVSCLVYLPRDRYTTAVRL Mflv_2569|M.gilvum_PYR-GCK ARGLLDMAMAVVDLGARRRTLLFMRADPLAHFVSCLVYLPRDRYTTVVRL MSMEG_4699|M.smegmatis_MC2_155 SKQLLEMALAVVDLGSRRRTLLFLRADHLAHFVSCLVYLPRDRYTTAVRL Mb2503c|M.bovis_AF2122/97 AQRLLTMARAVVDLGSQRQALLFLRADRLQYFVSCLVYMPRDRYTTAVRM Rv2476c|M.tuberculosis_H37Rv AQRLLTMARAVVDLGSQRQALLFLRADRLQYFVSCLVYMPRDRYTTAVRM MMAR_3829|M.marinum_M SEQLLAMAKAVVDLGSQRRALLFLRVDRLQFFVSCLVYLPRDRYTTAVRL MAV_1696|M.avium_104 SERLLAMAKAVVDLGPQRNALLFLRADSLQYFVSCLVYLPRDRYTTAVRL MLBr_01249|M.leprae_Br4923 AERLFTMAKEVVDLGSGRRALLFLRADRLQYFVSCLVYVPRDRYTTGVRL TH_0917|M.thermoresistible__bu -------------------------------------------------- MAB_1561|M.abscessus_ATCC_1997 VDRLYDIVTASRNIGAHPGSLLFLRADELGNFVTALVYLPRDRYTTTVRL Mvan_4069|M.vanbaalenii_PYR-1 EMQDILVRELGGVSIDYAARVSESPWAVVHFTVRMPEGSRPQD------I Mflv_2569|M.gilvum_PYR-GCK EMQDILVRELGGVSIDYAARVSESPWAVVHFTVRLPAGLRQHE------V MSMEG_4699|M.smegmatis_MC2_155 EMQDILVRELGGAGIDYSARVSESPWAVVHFTVRLPEGTAADS------V Mb2503c|M.bovis_AF2122/97 QFEDILVREFGGTRLEFTARVSESPWALMHFMVRLPEVGVAGEGAAAPPV Rv2476c|M.tuberculosis_H37Rv QFEDILVREFGGTRLEFTARVSESPWALMHFMVRLPEVGVAGEGAAAPPV MMAR_3829|M.marinum_M QIEDILVREFGGTRLEFTARVSESPWALMHFMVRLPEDVATGS------I MAV_1696|M.avium_104 QIEDILVREFGGTRLEFTARVSESPWALMHFMVRLPTDDPAAK-----PV MLBr_01249|M.leprae_Br4923 QIEDILVREFGGTQVEFTARVSESPWALMHFMVRLSEGAATGS------V TH_0917|M.thermoresistible__bu -------------------------------------------------- MAB_1561|M.abscessus_ATCC_1997 AMQDTLVRELGGTGIDYTARVSESPWALVHFTVRLPENSPHNS------I Mvan_4069|M.vanbaalenii_PYR-1 DVSEPNESRIQDLLTEAARTWSDRLLGAVSAGG--EVDQATAEHYASAFS Mflv_2569|M.gilvum_PYR-GCK DVSDDNEARIQDLLTEAARTWGDRLMGALPAGG--PVDHGTADHYASAFP MSMEG_4699|M.smegmatis_MC2_155 DTSLENESRIQDLLTEATRNWGDRMISAAAAA---SISPAALEHYAHAFP Mb2503c|M.bovis_AF2122/97 DVSEANRIRIQGLLTEAARTWADRLIG-AAAAG--SVGQADAMHYAAAFS Rv2476c|M.tuberculosis_H37Rv DVSEANRIRIQGLLTEAARTWADRLIGAAAAAG--SVGQADAMHYAAAFS MMAR_3829|M.marinum_M DVSEANRSRIQALLSEAARTWADRLIG-AASDA--SVRHADAEHYAAAFP MAV_1696|M.avium_104 DVSEDNRVRIQGLLSEAARTWTDRLVA-AAAEG--AVGHADAEYYADAFP MLBr_01249|M.leprae_Br4923 DVSEGNRIRIQAMLSEAARTWSDRLIAAAASFSEGSVSYAEAEHYAATFS TH_0917|M.thermoresistible__bu -------------------------------------------------- MAB_1561|M.abscessus_ATCC_1997 DTSEANRVRIQGLLTQTTRTWSDRLVRAVRPDS--PIDRACAERYSVILP Mvan_4069|M.vanbaalenii_PYR-1 EVYKQAIDPVHALADIAVIEELQDNSVKLVLADSDDTAESGVSHLNWYLG Mflv_2569|M.gilvum_PYR-GCK EVYKQANTPARALDDIAIIEELHDNTVKLVLADSDDTETSGVSDLNWYLG MSMEG_4699|M.smegmatis_MC2_155 EDYKQAFAPQDAIADISLIEALQDDSVKLVLAD---TAEDRVWKLTWYLG Mb2503c|M.bovis_AF2122/97 EAYKQAVTPADAIGDIAVITELTDDSVKLVFSER---DEQGVAQLTWFLG Rv2476c|M.tuberculosis_H37Rv EAYKQAVTPADAIGDIAVITELTDDSVKLVFSER---DEQGVAQLTWFLG MMAR_3829|M.marinum_M EAYKQAVAPADAIDHIAIINELADDSVKLVFSDR---TADGVAQLTWFLG MAV_1696|M.avium_104 EVYKQAISPADAIGHIAIIKELQDNSVKLVFTD----GEDGSAQLTWFLG MLBr_01249|M.leprae_Br4923 ETYKQAVTPADAIDHIAIIKELADDSVKLVFFER---KADGFAQLTWFLG TH_0917|M.thermoresistible__bu -------------------------------------------------- MAB_1561|M.abscessus_ATCC_1997 EVFKQNVPPAEAIADIARIEGLQEDSIDLAYDAD----ELGTGVLSMYLG Mvan_4069|M.vanbaalenii_PYR-1 GRSASLSRLLPMLQSMGVVVLEERPFTVVRPDGLPVWIYQFKVSPHRGIP Mflv_2569|M.gilvum_PYR-GCK GQSASLSRLLPMLQSMGVVVLEERPFTVTRPDGLPVWIYQFKVSPHRGIP MSMEG_4699|M.smegmatis_MC2_155 GHSASLSELLPMLQSMGVVVLEERPFTLRRTDGLPVWIYQFKISPHPSIP Mb2503c|M.bovis_AF2122/97 GRTASLSQLLPMLQSMGVVVLEERPFSVTRPDGLPVWIYQFKISPHPTIP Rv2476c|M.tuberculosis_H37Rv GRTASLSQLLPMLQSMGVVVLEERPFSVTRPDGLPVWIYQFKISPHPTIP MMAR_3829|M.marinum_M GCTASLSQLLPMLQSMGVVVLEERPFTVTRPDGLPVWIYQFKISPHPTIP MAV_1696|M.avium_104 GRTASLSQLLPMLQSMGVVVLEERPFTVTRSDGLPVWIYQFRISPHPTIE MLBr_01249|M.leprae_Br4923 GRSASLSQLLPMLQSMGVVVLEERPFTVARTDGLPVWIYQFKISPHPTIP TH_0917|M.thermoresistible__bu -------------------------------------------------- MAB_1561|M.abscessus_ATCC_1997 GRSASLSQVLPVLHSMGVDVLEERPYHFTRPDGLAVSLYAFRIVVHPAIA Mvan_4069|M.vanbaalenii_PYR-1 EAPPGPQREATAERFADAVTAIWHGNAEIDRFNELVLRAELTWQQVAVLR Mflv_2569|M.gilvum_PYR-GCK QAPPGPERDATAERFADTVTAIWHGNAEIDRFNELVLRAGLTWQQVAVLR MSMEG_4699|M.smegmatis_MC2_155 HAPDAEAQRDTAQRFADAVTAIWHGRVEIDRFNELVMRAGLTWQQVVVLR Mb2503c|M.bovis_AF2122/97 LAPTVAERAATAHRFAEAVTAIWHGRVEIDRFNELVMRAGLTWQQVVLLR Rv2476c|M.tuberculosis_H37Rv LAPTVAERAATAHRFAEAVTAIWHGRVEIDRFNELVMRAGLTWQQVVLLR MMAR_3829|M.marinum_M KATVPAERAAAAQRFADAVTAIWQGRIEIDRFNELVMRAGLTWQQVVLLR MAV_1696|M.avium_104 LASTPDERDAMAERFADAVTAIWQGRLEVDRFNELVMRAGLRWQQVVLLR MLBr_01249|M.leprae_Br4923 LASTANERELTAKRFSDAVTAIWQGRVEIDRFNELVMRARLTWQQVVLLR TH_0917|M.thermoresistible__bu -------------------------------------------------- MAB_1561|M.abscessus_ATCC_1997 RTFDAEGTARRADLLTRAIDAVWHGRVETDRFNELVLRAGLTAGQITILR Mvan_4069|M.vanbaalenii_PYR-1 AYARYLKQAGFAYSQSHIESVLNDNAGTARSLIALFEALFRPVEQGPG-A Mflv_2569|M.gilvum_PYR-GCK AYAKYLKQAGFPYSQSHIASVLNDNAGTARSLVELFEALYSPVDGNPGGA MSMEG_4699|M.smegmatis_MC2_155 AYAKYLRQAGFPYSQSHIESVLNENPHTTRSLIDLFEALFDPSQETDG-- Mb2503c|M.bovis_AF2122/97 AYAKYLRQAGFPYSQSYIESVLNEHPATVRSLVDLFEALFVP-VPSGSAS Rv2476c|M.tuberculosis_H37Rv AYAKYLRQAGFPYSQSYIESVLNEHPATVRSLVDLFEALFVP-VPSGSAS MMAR_3829|M.marinum_M AYSRYLRQAGFPYSQSYIESVLNEHPSTARSLVLLFEALFDP-RPAGSPV MAV_1696|M.avium_104 AYAKYLRQANFPYSQSYIEAVLNEHPSTARSLVALFEALFDP-DPD-SSA MLBr_01249|M.leprae_Br4923 AYAKYLRQAGFNYSQSYIESVLNEHPSTARSLVALFEALFDP-SPLSSST TH_0917|M.thermoresistible__bu -------------------------------------------------- MAB_1561|M.abscessus_ATCC_1997 GYAKYLRQAGFPYSQAHIETVLADNSQTARDFVELFEARFDP----ESTD Mvan_4069|M.vanbaalenii_PYR-1 NRDAQAAAAAVAADIDALVSLDTDRVLRAFASMIQATLRTNYFITGQESA Mflv_2569|M.gilvum_PYR-GCK NRDAQSAAAAVAADIDALVSLDTDRVLRAFASMIQATLRTNYFVTAADSA MSMEG_4699|M.smegmatis_MC2_155 RRDAQGAAAAVAADIDALVSLDTDRVLRAFANLIEATLRTNYFVARPDSA Mb2503c|M.bovis_AF2122/97 NRDAQAAAAAVAADIDALVSLDTDRILRAFASLVQATLRTNYFVTRQGSA Rv2476c|M.tuberculosis_H37Rv NRDAQAAAAAVAADIDALVSLDTDRILRAFASLVQATLRTNYFVTRQGSA MMAR_3829|M.marinum_M SPDAQAAAAAVAADIDALVSLDTDRILRAFASLVQATLRTNYFVSREGSA MAV_1696|M.avium_104 GRDAQAAAAAVAADIDALVSLDTDRILRAFASLVQATLRTNYFVTREGSA MLBr_01249|M.leprae_Br4923 NCDAQAAAAAVAADIDALVSLDTDRILRAFASLVQATLRTNYFVTQKFSA TH_0917|M.thermoresistible__bu -----------------VVSLDTDRVLRAFASLIEATLRTNYFVSRDDSD MAB_1561|M.abscessus_ATCC_1997 DTIADAKAAQVLAEIDKVVSLDTDRVLRAFFGLIQATLRTNYFVKKEDSA :*******:**** .:::********: * Mvan_4069|M.vanbaalenii_PYR-1 RARNVLSLKLNPQLIDELPLPRPKFEIFVYSPRVEGVHLRFGFVARGGLR Mflv_2569|M.gilvum_PYR-GCK RARNVLSFKLNPELIDELPLPRPKFEIFVYSPRVEGVHLRFGFVARGGLR MSMEG_4699|M.smegmatis_MC2_155 RARNVLAFKLNPLVIKELPLPRPKFEIFVYSPRVEGVHLRFGFVARGGLR Mb2503c|M.bovis_AF2122/97 RCRDVLALKLNAQLIDELPLPRPRYEIFVYSPRVEGVHLRFGPVARGGLR Rv2476c|M.tuberculosis_H37Rv RCRDVLALKLNAQLIDELPLPRPRYEIFVYSPRVEGVHLRFGPVARGGLR MMAR_3829|M.marinum_M RSRDVLSVKLDAQLIDELPLPRPKYEIFVYSPRVEGVHLRFGPVARGGLR MAV_1696|M.avium_104 RARNVLVIKLDAQLIDELPLPRPKYEIFVYSPRVEGVHLRFGPVARGGLR MLBr_01249|M.leprae_Br4923 RSKGVLVLKLDAQLINELPLPRPKFEIFVYSPRVEGVHLRFGAVARGGLR TH_0917|M.thermoresistible__bu RARGVFSVKLRPALIKELPLPRPMFEIFVYSPRVEGVHLRFGHVARGGLR MAB_1561|M.abscessus_ATCC_1997 RAKGVLSFKLNPREIAELPEPRPRFEIFVYSPRVEGVHLRFGPVARGGLR *.:.*: .** . * *** *** :***************** ******* Mvan_4069|M.vanbaalenii_PYR-1 WSDRREDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKHPPAPTGDAAAD Mflv_2569|M.gilvum_PYR-GCK WSDRREDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKKPPAPTGDAAAD MSMEG_4699|M.smegmatis_MC2_155 WSDRREDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPTLTGDAAAD Mb2503c|M.bovis_AF2122/97 WSDRRDDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPLPTGDPAAD Rv2476c|M.tuberculosis_H37Rv WSDRRDDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPLPTGDPAAD MMAR_3829|M.marinum_M WSDRRDDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPLSTGDAATD MAV_1696|M.avium_104 WSDRRDDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPLPSGDGAAD MLBr_01249|M.leprae_Br4923 WSDRLDDFRTEILGLVKAQAVKNAVIVPVGAKGGFVLKRPPLPTGDAAAD TH_0917|M.thermoresistible__bu WSDRREDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKRPPAPTGDAAAD MAB_1561|M.abscessus_ATCC_1997 WSDRREDFRTEILGLVKAQAVKNAVIVPVGAKGGFVVKNPPAVTGDAAAD **** :******************************:*.** :** *:* Mvan_4069|M.vanbaalenii_PYR-1 RDATREEGVACYRLFIAGLLDITDNVDKVTGGIVAPADVVRRDGDDAYLV Mflv_2569|M.gilvum_PYR-GCK RDATREEGVACYRLFIAGLLDITDNVDKISGDVVTPAEVVRRDGDDAYLV MSMEG_4699|M.smegmatis_MC2_155 REATRAEGVECYRLFISGLLDVTDNVDKATGAVVTPPEVVRRDGEDAYLV Mb2503c|M.bovis_AF2122/97 RDATRAEGVACYQLFISGLLDVTDNVDHATASVNPPPEVVRRDGDDAYLV Rv2476c|M.tuberculosis_H37Rv RDATRAEGVACYQLFISGLLDVTDNVDHATASVNPPPEVVRRDGDDAYLV MMAR_3829|M.marinum_M REATRAEGVACYQLFISGLLDVTDNVDHTTGVVSPPPEVLRRDGDDAYLV MAV_1696|M.avium_104 RDATRAEGVACYQLFISGLLDVTDNVDHATGKVSPPPEVVRRDGDDAYLV MLBr_01249|M.leprae_Br4923 RDAMRAEGIACYQLFISGLLDITDNVDHATGKVNAPPQVVRRDSDDAYLV TH_0917|M.thermoresistible__bu REAARAEGIACYRLFVSGLLDITDNVDKTTGAVVPPAEVVRRDGDDAYLV MAB_1561|M.abscessus_ATCC_1997 RDAFRAEGVECYRRFISGLLDITDNRDRTTNAVVPPEGVRRRDGDDPYLV *:* * **: **: *::****:*** *: : : .* * ***.:*.*** Mvan_4069|M.vanbaalenii_PYR-1 VAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITAKGAW Mflv_2569|M.gilvum_PYR-GCK VAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITAKGAW MSMEG_4699|M.smegmatis_MC2_155 VAADKGTATFSDIANEVAKSYGFWLGDAFASGGSIGYDHKAMGITAKGAW Mb2503c|M.bovis_AF2122/97 VAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITARGAW Rv2476c|M.tuberculosis_H37Rv VAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITARGAW MMAR_3829|M.marinum_M VAADKGTATFSDIANEVANSYGFWLGDAFASGGSVGYDHKAMGITAKGAW MAV_1696|M.avium_104 VAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITARGAW MLBr_01249|M.leprae_Br4923 VAADKGTATFSDIANDVAKSYGFWLGDAFASGGSVGYDHKAMGITAKGAW TH_0917|M.thermoresistible__bu VAADKGTATFSDIANEVAQSYGFWLGDAFASGGSVGYDHKAMGITARGAW MAB_1561|M.abscessus_ATCC_1997 VAADKGTATFSDIANDVALSYGFWLGDAFASGGSVGYDHKAMGITARGAW ***************:** ***************:***********:*** Mvan_4069|M.vanbaalenii_PYR-1 ESVKRHFREMGVDTQSEDFTVVGVGDMSGDVFGNGMLLSKHIRLLAAFDH Mflv_2569|M.gilvum_PYR-GCK ESVKRHFREMGIDTQSEDFTVVGVGDMSGDVFGNGMLLSEHIRLLAAFDH MSMEG_4699|M.smegmatis_MC2_155 ESVKRHFREMGVDTQTQDFTVVGIGDMSGDVFGNGMLLSKHIRLVAAFDH Mb2503c|M.bovis_AF2122/97 EAVKRHFREIGIDTQTQDFTVVGIGDMSGDVFGNGMLLSKHIRLIAAFDH Rv2476c|M.tuberculosis_H37Rv EAVKRHFREIGIDTQTQDFTVVGIGDMSGDVFGNGMLLSKHIRLIAAFDH MMAR_3829|M.marinum_M EAVKRHFREMGIDTQTEDFTVVGVGDMSGDVFGNGMLLSKHIRLIAAFDH MAV_1696|M.avium_104 EAVKRHFREMGVDTQTEDFTVVGIGDMSGDVFGNGMLLSKHIRLLAAFDH MLBr_01249|M.leprae_Br4923 EAVKRHFREMGVDTQNEDFTVVGIGDMSGDVFGNGMLLSKHIRLIAAFDH TH_0917|M.thermoresistible__bu ESVKRHFREMGVDTQTQDFTVVGIGDMSGDVFGNGMLLSKHIRLVAAFDH MAB_1561|M.abscessus_ATCC_1997 ESVKRHFLEIGIDTQTQDFTVVGVGDMSGDVFGNGMLLSQHIKLVAAFDH *:***** *:*:***.:******:***************:**:*:***** Mvan_4069|M.vanbaalenii_PYR-1 RHIFIDPTPDAASSWEERKRLFELPRSSWEDYDTSLISPGGGVYSREQKS Mflv_2569|M.gilvum_PYR-GCK RHIFIDPTPDAASSYAERRRLFDLPRSSWDDYDKSLISAGGGVYSREQKS MSMEG_4699|M.smegmatis_MC2_155 RDIFLDPNPDAGRSWDERKRLFDLPRSSWADYDKSLISEGGGVYSRQQKS Mb2503c|M.bovis_AF2122/97 RHIFLDPNPDAAVSWAERRRMFELPRSSWGDYDRSLISEGGGVYSREQKA Rv2476c|M.tuberculosis_H37Rv RHIFLDPNPDAAVSWAERRRMFELPRSSWSDYDRSLISEGGGVYSREQKA MMAR_3829|M.marinum_M RHVFLDPNPDAAASWQERQRMFDLPRSSWDDYNKSLISEGGGVYSREQKS MAV_1696|M.avium_104 RHIFLDPNPDAAASWEERRRMFELPRSSWDDYDKSLISEGGGVYSREHKS MLBr_01249|M.leprae_Br4923 RHVFLDPDPDAAVSWAERQRMFDLPRSSWDDYNKSLISEGGGVYSREQKA TH_0917|M.thermoresistible__bu RHIFLDPDPDPARSWEERKRLFELPRSSWDDYDTSVISRGGGVYSRQQKS MAB_1561|M.abscessus_ATCC_1997 RHIFLDPNPDPASSWAERKRMFALERSSWADYNSALISAGGGVYSKEQKS *.:*:** **.. *: **:*:* * **** **: ::** ******:::*: Mvan_4069|M.vanbaalenii_PYR-1 IPVSAQARAALGLDDQVT----DLTPPALMKAILKAPADLLWNGGIGTYV Mflv_2569|M.gilvum_PYR-GCK IPISDEARAALGIEGDAT----EMTPPALMKAILKAPADLLWNGGIGTYI MSMEG_4699|M.smegmatis_MC2_155 IPISPQVRTALGLDADVE----ELTPPALIKAILKAPVDLLWNGGIGTYI Mb2503c|M.bovis_AF2122/97 IPLSAQVRAVLGIDGSVDGGAAEMAPPNLIRAILRAPVDLLFNGGIGTYI Rv2476c|M.tuberculosis_H37Rv IPLSAQVRAVLGIDGSVDGGAAEMAPPNLIRAILRAPVDLLFNGGIGTYI MMAR_3829|M.marinum_M IPVSDQVRNALGIGGDVT----EMTPPNLIRAILQAPVDLLFNGGIGTYI MAV_1696|M.avium_104 IPVSPQVRDALGLDGSGGGVVTEMTPPNLIKAILQAPVDLLFNGGIGTYI MLBr_01249|M.leprae_Br4923 IPTSPQVRTALGIDGEVT----EMAPPNLIRAILQAPVDLLFNGGIGTYI TH_0917|M.thermoresistible__bu IPVSAEVRAALGLDGDVD----ALTPPAMIRAILRAPVDLLFNGGIGTYI MAB_1561|M.abscessus_ATCC_1997 IPISPEVRDVLGLDSDVV----EMTPPQLVRAILLAPVDLFFNGGIGTYV ** * :.* .**: . ::** :::*** **.**::*******: Mvan_4069|M.vanbaalenii_PYR-1 KAETEADADVGDRANDAVRVNGNEVRAKVIGEGGNLGVTSRGRTEFDLCG Mflv_2569|M.gilvum_PYR-GCK KAETEADADVGDRANDPVRVNGNQVRAKVVGEGGNLGVTSLGRTEFDLCG MSMEG_4699|M.smegmatis_MC2_155 KAETEADADVGDRANDQIRVCGNQVRAKVIGEGGNLGVTALGRIEFDLAG Mb2503c|M.bovis_AF2122/97 KAESESDADVGDRANDPVRVNANQVRAKVIGEGGNLGVTALGRVEFDLSG Rv2476c|M.tuberculosis_H37Rv KAESESDADVGDRANDPVRVNANQVRAKVIGEGGNLGVTALGRVEFDLSG MMAR_3829|M.marinum_M KAESESDADVGDRANNPVRVNANQVRAKVIGEGGNLGVTALGRVEFDLSG MAV_1696|M.avium_104 KAESESDADVGDRANDPVRVNGSSVRAKVIGEGGNLGVTALGRVEFDLSG MLBr_01249|M.leprae_Br4923 KAETESVADVGDRANDPVRVNANQVRAKVIGEGGNLGVTALGRVEFDLSG TH_0917|M.thermoresistible__bu KAESESDADVGDRANDPVRVNGNQVRAKVIGEGGNLGVTPLGRVEYDLAG MAB_1561|M.abscessus_ATCC_1997 KAESESQADVGDKANDAVRVNGNQVRAKVIGEGGNLGLTSRGRIEFELNG ***:*: *****:**: :** ...*****:*******:*. ** *::* * Mvan_4069|M.vanbaalenii_PYR-1 GRINTDAMDNSAGVDCSDHEVNIKILIDSLVTAGKVEESGRSALLSSMTD Mflv_2569|M.gilvum_PYR-GCK GRINTDAMDNSAGVDCSDHEVNIKILIDSLVTAGKVAEADRTELLLSMTD MSMEG_4699|M.smegmatis_MC2_155 GRINTDALDNSAGVDCSDHEVNIKILIDSAVTAGKVTPEERTELLLSMTD Mb2503c|M.bovis_AF2122/97 GRINTDALDNSAGVDCSDHEVNIKILIDSLVSAGTVKADERTQLLESMTD Rv2476c|M.tuberculosis_H37Rv GRINTDALDNSAGVDCSDHEVNIKILIDSLVSAGTVKADERTQLLESMTD MMAR_3829|M.marinum_M GRINTDALDNSAGVDCSDHEVNIKILIDSLVSAGKVRTDERKQLLESMTD MAV_1696|M.avium_104 GRINTDAMDNSAGVDCSDHEVNIKILIDSLVTAGKVKPQERKPLLESMTD MLBr_01249|M.leprae_Br4923 GRINTDAMDNSAGVDCSDHEVNIKILIDSLVTAGKVKVEERKHLLESMTD TH_0917|M.thermoresistible__bu GRINTDALDNSAGVDCSDHEVNIKILIDSLVAAGKIGADQRTDLLMSMTD MAB_1561|M.abscessus_ATCC_1997 GRVNTDALDNSAGVDCSDHEVNIKILIDSLVSAGKIEASERTALLESMTD **:****:********************* *:**.: *. ** **** Mvan_4069|M.vanbaalenii_PYR-1 EVGRLVLADNESQNDLMGTSRANAASLLNVHGRMIRSFVEERGLNRELEA Mflv_2569|M.gilvum_PYR-GCK EVGRLVLADNESQNDLMGTSRANAASLLNVHARMIKDFVERRGLNRELEA MSMEG_4699|M.smegmatis_MC2_155 EVGELVLADNRDQNDLMGTSRANAASLLSVHARMIKDLVDNRGLNRELEA Mb2503c|M.bovis_AF2122/97 EVAQLVLADNEDQNDLMGTSRANAASLLPVHAMQIKYLVAERGVNRELEA Rv2476c|M.tuberculosis_H37Rv EVAQLVLADNEDQNDLMGTSRANAASLLPVHAMQIKYLVAERGVNRELEA MMAR_3829|M.marinum_M EVAQLVLTDNSDQNDLMGTSRANPVSLLPVHADQIRYLVAERGISRELEA MAV_1696|M.avium_104 EVAALVLTDNEDQNDLIGTSRANAPSLLPVHARQIQYLVDERGLNRELEA MLBr_01249|M.leprae_Br4923 EVARLVLTDNEDQNDLIGTSRANAANMLSVHAMQIKYLVDERGVNRELEA TH_0917|M.thermoresistible__bu EVADMVLAHNARQNDLIGTSRANTAAMLTVHARLIDDLVENHGVNRELEA MAB_1561|M.abscessus_ATCC_1997 DVATLVLADNESQNNLMGTSRANAASLLSVHARQIAYLVNERGLDRELEA :*. :**:.* **:*:******. :* **. * :* .:*:.***** Mvan_4069|M.vanbaalenii_PYR-1 LPSEKEIRRREEAGIGLTSPELATLMAHVKLALKDDLLAGDLPDQEVFAS Mflv_2569|M.gilvum_PYR-GCK LPSEKEILRRTEAGLGLTSPELATLMAHVKLALKDDLLAGELPDQEVFAS MSMEG_4699|M.smegmatis_MC2_155 LPSEKEIRRRADAGIGLTSPELATLMAHVKLALKDDVLASDLPDQEVFAS Mb2503c|M.bovis_AF2122/97 LPSEKEIARRSEAGIGLTSPELATLMAHVKLGLKEEVLATELPDQDVFAS Rv2476c|M.tuberculosis_H37Rv LPSEKEIARRSEAGIGLTSPELATLMAHVKLGLKEEVLATELPDQDVFAS MMAR_3829|M.marinum_M LPSEKEIARRSEAGIGLTSPELATLMAHVKLALKETMLTTELPDQDVFAS MAV_1696|M.avium_104 LPSEKEIQRRAEAGIGLTSPELCTLMAHVKLDLKEQMLQTELTEQDVFAS MLBr_01249|M.leprae_Br4923 LPSEKEIQRRSEAGIGLTSPELSTLMAHVKLALKEQMLATELPDQDVFVS TH_0917|M.thermoresistible__bu LPSDKEIARRSDTGVGLTSPELATVMAHVKLTLKDALLASELPDQEVFAA MAB_1561|M.abscessus_ATCC_1997 LPSEKEIDRRAALGIGLTSPELATLMAHVKLGLKDDLLASDAPDQEVTLR ***:*** ** *:*******.*:****** **: :* : .:*:* Mvan_4069|M.vanbaalenii_PYR-1 RLPSYFPATLRDQFSPEIRAHQLRREIVTTMLVNDVVDTAGISYAYRVTE Mflv_2569|M.gilvum_PYR-GCK RLPSYFPTTLRERFGPDIRSHQLRREIVTTMLVNDVVDTAGISYAYRVAE MSMEG_4699|M.smegmatis_MC2_155 RLPYYFPTRLREELHGEIRSHQLRREIITTMLVNDLVDTAGISYAYRITE Mb2503c|M.bovis_AF2122/97 RLPRYFPTALRERFTPEIRSHQLRREIVTTMLINDLVDTAGITYAFRIAE Rv2476c|M.tuberculosis_H37Rv RLPRYFPTALRERFTPEIRSHQLRREIVTTMLINDLVDTAGITYAFRIAE MMAR_3829|M.marinum_M RLPSYFPKPLRERFAPEIRSHQLRREIVTTMVINDLVDTAGITYAFRITE MAV_1696|M.avium_104 RLPLYFPTPLRHRFTPEIRAHQLRREIVATMLINELVDAAGISYAFRIVE MLBr_01249|M.leprae_Br4923 RLPRYFPKPLRERFTPEIRSHQLRREIVTTMLINDLVDTAGISYAFRIAE TH_0917|M.thermoresistible__bu RLPSYFPRPLRD-FTAEIRGHQLRREIVSTMLVNDLVDTAGLTYAFRVCE MAB_1561|M.abscessus_ATCC_1997 RMVHYFPDVLRERFDAEIRQHPLRKEIYATMLVNSVVDCGGITYVYRLFE *: *** **. : :** * **:** :**::*.:** .*::*.:*: * Mvan_4069|M.vanbaalenii_PYR-1 DVGVAPVDAVRSFVAADAIFGVGRVWRQIREAGAN-GVPVAVTDRMTLDL Mflv_2569|M.gilvum_PYR-GCK DVGVAPIDAVRSFAAGDAIFGFGRVWRQIREAGAN-GVSVAVTDRMTLDL MSMEG_4699|M.smegmatis_MC2_155 DVGVGPVDAVRSYVAINAIFGIGDVWRRIRAAGDA-GVPTSVTDRMTLDL Mb2503c|M.bovis_AF2122/97 DVGVTPIDAVRTYVATDAIFGVGHIWRRIRAA----NLPIALSDRLTLDT Rv2476c|M.tuberculosis_H37Rv DVGVTPIDAVRTYVATDAIFGVGHIWRRIRAA----NLPIALSDRLTLDT MMAR_3829|M.marinum_M DVGVSPIDAVRTYMATDAIFGVSHIWRRIRAE----ELPVALSDRLTLDT MAV_1696|M.avium_104 DVGVSAVDAVRTYVATDAIFGVGEIWRRIRAA----NLPVALSDRLTLDT MLBr_01249|M.leprae_Br4923 DIGVGPIDAIRTYVATDAIFGVGDVLRRIRAA----NLSVVLSDRMTLDT TH_0917|M.thermoresistible__bu DAGVEPVDAVRSFVAVDAIFRVGEIWHAIRTAGAEGVLPVAVSDRMTLDL MAB_1561|M.abscessus_ATCC_1997 DAGTGSVDGLKTYVAVEAIFGLRSLWDRIRHA----DVPVAVSDRLTLDM * *. .:*.:::: * :*** . : ** :. ::**:*** Mvan_4069|M.vanbaalenii_PYR-1 RRLIDRAARWLLNYRPQPLAVGAEINRFADKVAALTPRMPDWLRGDDKAI Mflv_2569|M.gilvum_PYR-GCK RRLIDRATRWLLNYRPLPLAVGAEINRFADKVAALTPSMPDWLRGDDKAI MSMEG_4699|M.smegmatis_MC2_155 RRLVDRAGRWLLNYRPQPLAVGAEINRFGAKVAALTPRMSEWLRGDDKAI Mb2503c|M.bovis_AF2122/97 RRLIDRAGRWLLNYRPQPLAVGAEINRFAAMVKALTPRMSEWLRGDDKAI Rv2476c|M.tuberculosis_H37Rv RRLIDRAGRWLLNYRPQPLAVGAEINRFAAMVKALTPRMSEWLRGDDKAI MMAR_3829|M.marinum_M RRLIDRASRWLLNYRPQPLAVGAEINRFAAKVKALTPRMSEWLRGDDKAI MAV_1696|M.avium_104 RRLIDRAGRWLLNYRPQPLAVGAEINRFAAKVKALTPRMSEWLRGDDKAI MLBr_01249|M.leprae_Br4923 RRLIDRAGRWLLNYRPQPLAVGAEINRFAAKVKALTPRMSEWLRGDDQAI TH_0917|M.thermoresistible__bu RRLIDRAARWLLNFRPQPLAVGAEINRFAAKVAALTPRMSEWLCGADADI MAB_1561|M.abscessus_ATCC_1997 RRLLDRASRWLISYRPQPLAVGAEINRFAEGIAELSPKLTTWLRGHDLEI ***:*** ***:.:** ***********. : *:* :. ** * * * Mvan_4069|M.vanbaalenii_PYR-1 VAKEAAEFSSQGVPDDVAYMVASGLYQFSLLDVIDIADIVDRDPAEVADA Mflv_2569|M.gilvum_PYR-GCK VEKEAGEFSAHGVAEDVAYTVATGLYQFSLLDVIDIADIIDRDPAEVADA MSMEG_4699|M.smegmatis_MC2_155 VSKEAGDFASHGVPEDLAYHIATGLYQYSLLDVIDIADIVDREPDEVADT Mb2503c|M.bovis_AF2122/97 VEKTAAEFASQGVPEDLAYRVSTGLYRYSLLDIIDIADIADIDAAEVADT Rv2476c|M.tuberculosis_H37Rv VEKTAAEFASQGVPEDLAYRVSTGLYRYSLLDIIDIADIADIDAAEVADT MMAR_3829|M.marinum_M VEKTSEEFIAQGAPEDLAYRVAVGLYRYSLLDIIDIADIADIDAAEVADT MAV_1696|M.avium_104 VEKEAAEFESQGAPRDLAYLVAAGLYRFSLLDIIDIGDINDIDAAEVADT MLBr_01249|M.leprae_Br4923 VEQQATEFVSQGAPEDLAYRVAVGLYRYSLLDIIDIADITELDPAEVADT TH_0917|M.thermoresistible__bu VARRTADFVEHGASRQLAYLVSSALYQFSLLDIIDIADILDREPAEVAET MAB_1561|M.abscessus_ATCC_1997 VTKQTEDLVALGVPFDLASDVASCLYGFSLLDIIDIADIADRDGAEVADL * : : :: *.. ::* :: ** :****:***.** : : ***: Mvan_4069|M.vanbaalenii_PYR-1 YFALMDHLGTDGLLTAVSRLSRYDRWHSLARLAIRDDIYGSLRALCFDVL Mflv_2569|M.gilvum_PYR-GCK YFALMDHLGTDGLLTAVSRLSRNDRWHSLARLAIRDDIYGSLRALCFDVL MSMEG_4699|M.smegmatis_MC2_155 YFALMDHLGADALLTAVSRLSRDDRWHSLARLAIRDDIYGSLRALCFDVL Mb2503c|M.bovis_AF2122/97 YFALMDRLGTDGLLTAVSQLPRHDRWHSLARLAIRDDIYGALRSLCFDVL Rv2476c|M.tuberculosis_H37Rv YFALMDRLGTDGLLTAVSQLPRHDRWHSLARLAIRDDIYGALRSLCFDVL MMAR_3829|M.marinum_M YFALVDRLGADGLLTAVSELPRKDRWHSLARLAIRDDIYGALRSLCFDVI MAV_1696|M.avium_104 YFALMDRLGTDGLLTAVSELPRNDRWHSLARLAICDDIYASLRSLCFDVL MLBr_01249|M.leprae_Br4923 YFSLMDRLGTDGLLTAVSKLPQNDRWHSLARLAIRDDIYASLRSLCFDVL TH_0917|M.thermoresistible__bu YFALMGHLNADALLTAVSELPRSDRWHSLARLAIRDDIYGSLRLLTVDVL MAB_1561|M.abscessus_ATCC_1997 YFTLMDDLRVDDLLTAVSQLERNDRWHSLARLAIRDDIYSSLRALTMDVL **:*:. * .* ******.* : *********** ****.:** * .**: Mvan_4069|M.vanbaalenii_PYR-1 AVGEPDEDGVEKIAEWETTNSSRVSRARRTLAELYESGEHDLATLSVAAR Mflv_2569|M.gilvum_PYR-GCK AVGEPDENGVEKIAEWEMTNRSRISRARRTLTELYESGEHDLATLSVAAR MSMEG_4699|M.smegmatis_MC2_155 AVGEPDENGEEKIAEWETTNSSRVTRARRTLTEIYKDGEQDLATLSVAAR Mb2503c|M.bovis_AF2122/97 AVGEPGESSEQKIAEWEHLSASRVARARRTLDDIRASGQKDLATLSVAAR Rv2476c|M.tuberculosis_H37Rv AVGEPGESSEQKIAEWEHLSASRVARARRTLDDIRASGQKDLATLSVAAR MMAR_3829|M.marinum_M AVGEPDESSEQKILEWEQLSASRVDRARRTLNEIRDSGQKDLATLSVAAR MAV_1696|M.avium_104 AVGEPDESGEEKIAEWEHLSASRVERARRTLIEIQESGAKDLATLSVAAR MLBr_01249|M.leprae_Br4923 AVGEPDESGEEKIAEWEHISASRVERARLMLAEIHASGEKDLATLSVAAR TH_0917|M.thermoresistible__bu AVGEPDESGEEKIAEWESTNSSRLRRARRTLDEIYQDDIRDLATLSVAAR MAB_1561|M.abscessus_ATCC_1997 SVGEPDETGEQKIAEWEFTNASRLERARGTLAEIFAAGEPDLATLSVAAR :****.* . :** *** . **: *** * :: . ********** Mvan_4069|M.vanbaalenii_PYR-1 QIRSMTRTSGTGSSG Mflv_2569|M.gilvum_PYR-GCK QIRSMTRTSGTGSSG MSMEG_4699|M.smegmatis_MC2_155 QIRSMTRTSGTGTTG Mb2503c|M.bovis_AF2122/97 QIRRMTRTSGRGISG Rv2476c|M.tuberculosis_H37Rv QIRRMTRTSGRGISG MMAR_3829|M.marinum_M QVRRMTRTSGRGISG MAV_1696|M.avium_104 QIRRMTRTSGRGSSS MLBr_01249|M.leprae_Br4923 QIRRMTRTSGRGSSG TH_0917|M.thermoresistible__bu QIRAMTRTSGTGSSA MAB_1561|M.abscessus_ATCC_1997 QIRGMIRSSITGPA- *:* * *:* * :