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M. tuberculosis H37Rv Rv2462c (tig)

annotation: trigger factor
coordinates: 2763891 - 2765291
length: 466

KSTVEQLSPTRVRINVEVPFAELEPDFQRAYKELAKQVRLPGFRPGKAPAKLLEARIGREAMLDQIVNDA
LPSRYGQAVAESDVQPLGRPNIEVTKKEYGQDLQFTAEVDIRPKISPPDLSALTVSVDPIEIGEDDVDAE
LQSLRTRFGTLTAVDRPVAVGDVVSIDLSATVDGEDIPNAAAEGLSHEVGSGRLIAGLDDAVVGLSADES
RVFTAKLAAGEHAGQEAQVTVTVRSVKERELPEPDDEFAQLASEFDSIDELRASLSDQVRQAKRAQQAEQ
IRNATIDALLEQVDVPLPESYVQAQFDSVLHSALSGLNHDEARFNELLVEQGSSRAAFDAEARTASEKDV
KRQLLLDALADELQVQVGQDDLTERLVTTSRQYGIEPQQLFGYLQERNQLPTMFADVRRELAIRAAVEAA
TVTDSDGNTIDTSEFFGKRVSAGEAEEAEPADEGAARAASDEATT*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv2462ctig-100% (466)trigger factor

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2489ctig0.099.79% (466) trigger factor
M. gilvum PYR-GCKMflv_2587tig1e-17063.44% (465) trigger factor
M. leprae Br4923MLBr_01481tig0.069.66% (468) trigger factor
M. abscessus ATCC 19977MAB_1580-1e-15661.17% (461) trigger factor (TF)
M. marinum MMMAR_3809tig0.079.58% (480) trigger factor (TF) protein TIG
M. avium 104MAV_1712tig0.075.22% (464) trigger factor
M. smegmatis MC2 155MSMEG_4674tig0.069.10% (466) trigger factor
M. thermoresistible (build 8)TH_0351tig0.068.80% (468) PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG
M. ulcerans Agy99MUL_3732tig0.084.51% (439) trigger factor
M. vanbaalenii PYR-1Mvan_4041tig1e-17164.53% (468) trigger factor

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2587|M.gilvum_PYR-GCK          MKSTVEKLSPTRVRINVEVPFAELEPDIDKAFKQLAQQIRLPGFRPGKAP
Mvan_4041|M.vanbaalenii_PYR-1       MKSTVEKLSPTRVRINVEVPFTELEPDIDRAFKQLAKQIRLPGFRPGKAP
MSMEG_4674|M.smegmatis_MC2_155      MKSTVEQLSPTRVRINVEVPFTELEPDFDRAFKELAKQVRLPGFRPGKAP
MAB_1580|M.abscessus_ATCC_1997      MKSTVEKLSPTRVRINVEVPFAELEPDFSKAYKELAQQVRLPGFRPGKAP
TH_0351|M.thermoresistible__bu      VKSTVEKLSPTRVRINVEVPFTELQPDFDRAYKELAKQVRLPGFRPGKAP
Rv2462c|M.tuberculosis_H37Rv        MKSTVEQLSPTRVRINVEVPFAELEPDFQRAYKELAKQVRLPGFRPGKAP
Mb2489c|M.bovis_AF2122/97           MKSTVEQLSPTRVRINVEVPFAELEPDFQRAYKELAKQVRLPGFRPGKAP
MMAR_3809|M.marinum_M               MKSSVEQLSPTRVRIKVEVPFAELEPDFQRAYKELAKQVRLPGFRPGRAP
MUL_3732|M.ulcerans_Agy99           MKSSVEQLSPTRVRIKVEVPFAELEPDFQRAYKELAKQVRLPGFRPGRAP
MLBr_01481|M.leprae_Br4923          MKSSVEQLNPTRVRINVEVPFTELEPDFQRAYKELARHVQLPGFRPGKVP
MAV_1712|M.avium_104                MKSTVEQLSPTRVRINVEVPFAELEPDFQRAYKELAKQVRLPGFRPGKAP
                                    :**:**:*.******:*****:**:**:.:*:*:**::::*******:.*

Mflv_2587|M.gilvum_PYR-GCK          RKLLEARVGRGAVLEQVVNDALPTRYSQAVTSESLQPIGQPEIEVTKLED
Mvan_4041|M.vanbaalenii_PYR-1       RKLLEARVGRGAVLEQVVNDALPARYSEAVTAESLQPIGQPEIEVTKLED
MSMEG_4674|M.smegmatis_MC2_155      RKLLEARIGRGAVLEQVVNDALPSRYSEAVSTSDLKPLGQPEIEITKLED
MAB_1580|M.abscessus_ATCC_1997      AKLLEARVGRAAVLEQVVNAALPARYSEAVTASDVKPLGQPEIEVTKIED
TH_0351|M.thermoresistible__bu      AKLLEARIGREAMLDQVVSDAIPARYSEAVASSDVRPLGQPDIEITKKEY
Rv2462c|M.tuberculosis_H37Rv        AKLLEARIGREAMLDQIVNDALPSRYGQAVAESDVQPLGRPNIEVTKKEY
Mb2489c|M.bovis_AF2122/97           AKLLEARIGREAMLDQIVNDALPSRYGQAVAESDVQPLGRPNIEVTKKEY
MMAR_3809|M.marinum_M               VKLLEARFGREAMLDQIVNDAVPSRYGQALAESEIQPLGRPDIEVTQKEY
MUL_3732|M.ulcerans_Agy99           VKLLEARFGREAMLDQIVNDAVPSRYGQALAESEIQPLGRPDIEVTQKEY
MLBr_01481|M.leprae_Br4923          ARLLEARFGRETLLDQVVNEAMPSRYGQALAESEVQPIGQPEIEVIRKEY
MAV_1712|M.avium_104                AKLLEARFGREAMLDQVVTEALPARYGQAVAESEVHPLGQPEIEVTKKEY
                                     :*****.** ::*:*:*. *:*:**.:*:: ..::*:*:*:**: : * 

Mflv_2587|M.gilvum_PYR-GCK          NEELVFTAEVDVRPEIDLPDLSTLTITVDPVSVTDEDIEAEIEALQKRFG
Mvan_4041|M.vanbaalenii_PYR-1       NEELVFTAEVDVRPDIDLPDLGALKITVDPISVTDEDVDAEIEALQKRFG
MSMEG_4674|M.smegmatis_MC2_155      NEELVFTAEVDIRPEITLPELESLKITVDPIEVTDEEVDAELQSLRARFG
MAB_1580|M.abscessus_ATCC_1997      GQELTFTAEVDVRPEIELPDLSGVAVTVKPVTVEDSEVEAELDALRARFG
TH_0351|M.thermoresistible__bu      GETIEFTAEVDIRPDIELPDLEALKIKVDPIEVTDEDIDAELQNLRARFG
Rv2462c|M.tuberculosis_H37Rv        GQDLQFTAEVDIRPKISPPDLSALTVSVDPIEIGEDDVDAELQSLRTRFG
Mb2489c|M.bovis_AF2122/97           GQDLQFTAEVDIRPKISLPDLSALTVSVDPIEIGEDDVDAELQSLRTRFG
MMAR_3809|M.marinum_M               GQDLAFTAEVDVRPEIALPDLTGLSVSVDAIEATDDEVNAELESLRARFG
MUL_3732|M.ulcerans_Agy99           GQDLAFTAEVDVRPEIALPDLTGLSVSVDAIEATDDEVNAELESLRARFG
MLBr_01481|M.leprae_Br4923          GQDLAFTVEVEVRPKIALPDFSTLKVVVDPVEVSTDDVEAELRSLRARFG
MAV_1712|M.avium_104                GQELAFTAEVDVRPELNLPDPGALKISVDPIEVTDEDVDAELQSLRARFG
                                    .: : **.**::**.:  *:   : : *..:    .:::**:  *: ***

Mflv_2587|M.gilvum_PYR-GCK          TLTGVERPAENGDFVSIDLSATVDGKDVPEAKTEGLSHELGSGQLIEGLD
Mvan_4041|M.vanbaalenii_PYR-1       TLTGVDRAAEDGDFVSIDLSATVDGKDVPEANTEGLSHEVGSGQLIEGLD
MSMEG_4674|M.smegmatis_MC2_155      TLKGVERGVQEGDFVSIDLSATVDGNEVPEAATEGLSHEVGSGQLIDGLD
MAB_1580|M.abscessus_ATCC_1997      TLKGVERAAENGDFVSIDLSATVDGKEVEEAATTGLSHEIGSGQLIDGLD
TH_0351|M.thermoresistible__bu      TLKGVERPVQDGDFVSIDLSATVDGTPVPEAATEGLSHEVGSGQLIEGLD
Rv2462c|M.tuberculosis_H37Rv        TLTAVDRPVAVGDVVSIDLSATVDGEDIPNAAAEGLSHEVGSGRLIAGLD
Mb2489c|M.bovis_AF2122/97           TLTAVDRPVAVGDVVSIDLSATVDGEDIPNAAAEGLSHEVGSGRLIAGLD
MMAR_3809|M.marinum_M               TLTEVERPVATGDFISIDLSAAVDGEDVPNAAAEGLSHEVGSGRLIAGLD
MUL_3732|M.ulcerans_Agy99           TLTGVERPVATGDFISIDLSAAVDGEDVPNAAAEGLSHEVRSGRLIAGLD
MLBr_01481|M.leprae_Br4923          TLIGVDRPVALGDFVSIDLSATINGEKVPNADAEGLSHEVGYGRLIAGLD
MAV_1712|M.avium_104                TLTGVERPVAEGDFVSIDLSATIDGQEVPGATAQGLSHEVGSGRLIEGLD
                                    **  *:* .  **.:******:::*  :  * : *****:  *:** ***

Mflv_2587|M.gilvum_PYR-GCK          EAIIGLSEDESKTFTTTLVAGEHAGREAEVTVTVKSIKVRELPELDDEFA
Mvan_4041|M.vanbaalenii_PYR-1       EAIIGLKADESKVFTTTLVAGEHAGQEAEVTVTVKSIKVRELPEVDDDFA
MSMEG_4674|M.smegmatis_MC2_155      EAIIGLKADESKTFTTKLVAGEYAGQDAEVTVTVKSVKERELPEPDDEFA
MAB_1580|M.abscessus_ATCC_1997      EAIIGLKAGEEKVFTTKLAAGEFAGQEAEVTVKVGSIKERELPDADDDFA
TH_0351|M.thermoresistible__bu      ETLVGMTEGETKTFTSKLVAGEHAGKEAEVTVTVKSVKERELPEPDDEFA
Rv2462c|M.tuberculosis_H37Rv        DAVVGLSADESRVFTAKLAAGEHAGQEAQVTVTVRSVKERELPEPDDEFA
Mb2489c|M.bovis_AF2122/97           DAVVGLSADESRVFTAKLAAGEHAGQEAQVTVTVRSVKERELPEPDDEFA
MMAR_3809|M.marinum_M               DAVVGLSVDESRVFTAKLAAGDHAGRDAEVTVTVKSVKERELPEPDDEFA
MUL_3732|M.ulcerans_Agy99           DAVVGLSVDESRVFTAKLAAGDHAGRDAEVTVTVKSVKERELPEPDDEFA
MLBr_01481|M.leprae_Br4923          DALVGLSAGESRVFTTQLATSKHAGQDAEVIVTVKSVKERELPEPDDEFA
MAV_1712|M.avium_104                EALIGMSVDESREFTTKLVSGEHAGQDAQVTVTVKSVKERELPEPDDEFA
                                    ::::*:. .* : **: *.:...**::*:* *.* *:* ****: **:**

Mflv_2587|M.gilvum_PYR-GCK          QLASEFDTMDELRADLREKVTRVKTVQQAEAIRDKAIEVLLEQTEVPLPE
Mvan_4041|M.vanbaalenii_PYR-1       QLASEFDTVEELRADLKEKISRFKRVQQAEAIRDKAIEVLLEQTEIPVPE
MSMEG_4674|M.smegmatis_MC2_155      QLASEYDTIEELRNSLVDQVRRLKSVQQAEQIRDKAIEALLEQTEVPLPE
MAB_1580|M.abscessus_ATCC_1997      QLASEFDTIGELKDSLTEQVKGRKRIAQADEIRDETITALLDKIEIPVPE
TH_0351|M.thermoresistible__bu      QLASEFDTIEELRESLAEQVRRVKRVQQAEQIRDKALEVLLEQVEVPLPE
Rv2462c|M.tuberculosis_H37Rv        QLASEFDSIDELRASLSDQVRQAKRAQQAEQIRNATIDALLEQVDVPLPE
Mb2489c|M.bovis_AF2122/97           QLASEFDSIDELRASLSDQVRQAKRAQQAEQIRNATIDALLEQVDVPLPE
MMAR_3809|M.marinum_M               QLASEFDTIDELRASLREQVLQAKRVGQAEQIRNATIDALLERVDVPTPE
MUL_3732|M.ulcerans_Agy99           QLASEFDTIDELRASLREQVLQAKRVGQAEQIRNATIDALLERVDVPTPE
MLBr_01481|M.leprae_Br4923          QLVSEFDTMAELRANLGDQVRKAKYAQQAEKIRDAAVDALLERVDVPLPE
MAV_1712|M.avium_104                QLASEFDTIDELRANLREQVGRVKRAQQAERIRDAAIDTLLEQVDIPLPE
                                    **.**:*:: **: .* :::   *   **: **: :: .**:: ::* **

Mflv_2587|M.gilvum_PYR-GCK          AVVQAQVDDTLHNAIHGLDHDEDRFADSLKEQGSSREEFDADNRANAEKA
Mvan_4041|M.vanbaalenii_PYR-1       AVVQAQVDDTLHNAIHGLDHDEDKFAESLKEQGSSREEFDADNRANAEKA
MSMEG_4674|M.smegmatis_MC2_155      KIVQAQIDEVVHNAIHGLDHDEEKFAEQLAEQGSSREEFDAETRTEAEKA
MAB_1580|M.abscessus_ATCC_1997      KILEEQIGNNLHEAVHGLDHNEERLNELLQEQGSSREEFDKDMRESATKS
TH_0351|M.thermoresistible__bu      KAVQAQIDDTLHNAIHDLDHDEERFAEVLAARGSSREEFDAENRANAEKA
Rv2462c|M.tuberculosis_H37Rv        SYVQAQFDSVLHSALSGLNHDEARFNELLVEQGSSRAAFDAEARTASEKD
Mb2489c|M.bovis_AF2122/97           SYVQAQFDSVLHSALSGLNHDEARFNELLVEQGSSRAAFDAEARTASEKD
MMAR_3809|M.marinum_M               SYVQAQYEGVLHSALSGINNDEARFNELLVEQGSSRDAFDAEARTASEKD
MUL_3732|M.ulcerans_Agy99           SYVQAQYEGVLHSALSGINNDEARFNELLVEQGSSRDAFDAEARTASEKD
MLBr_01481|M.leprae_Br4923          GIVQAQFNNALHDALSGLGHDEAKFAEVLAERGSSREEFEAEARSAAERD
MAV_1712|M.avium_104                AIVKAQVDSALHGALHSLNHDESKLEEVLAQQGKSREEFENETRTAAETD
                                      :: *    :* *: .:.::* :: : *  :*.**  *: : *  :   

Mflv_2587|M.gilvum_PYR-GCK          IKTQLLMDAIADKLEIQVGQNDLSERLVLMSRQYGLEPQQLLQMLQQNNQ
Mvan_4041|M.vanbaalenii_PYR-1       IKTQLLMDSIADKLEIQVGQNDLTERLVLMSRQYGLEPQQLLQMLQQNNQ
MSMEG_4674|M.smegmatis_MC2_155      VKTQLLMDAVADKLEIQVSQNDLTERLVLMSRQYGLEPQQLIQILQQNNQ
MAB_1580|M.abscessus_ATCC_1997      IKTELLLDVIADKFDINVDQQDLTERLVLMSRQYGIEPQQLVQYLTQQQQ
TH_0351|M.thermoresistible__bu      IKTQLLVDAIADHLEIQVGQEDITERLVLMSRQYGVEPQQMLAFLQQNNQ
Rv2462c|M.tuberculosis_H37Rv        VKRQLLLDALADELQVQVGQDDLTERLVTTSRQYGIEPQQLFGYLQERNQ
Mb2489c|M.bovis_AF2122/97           VKRQLLLDALADELQVQVGQDDLTERLVTTSRQYGIEPQQLFGYLQERNQ
MMAR_3809|M.marinum_M               VKRQLLLDALADDLKVQVGQEDLTERLVLTSRQYGIEPQQLFAYLQENNQ
MUL_3732|M.ulcerans_Agy99           VKRQLLLDALADDLKVQVGQEDLTERLVLTSRQYGIEPQQLFVYLQENNQ
MLBr_01481|M.leprae_Br4923          VTRQLLLDVVADDQKIQVGQDDLNERLLATSQQYGVDAQQLFGFLRENNR
MAV_1712|M.avium_104                VKKQLLLDALADKLQVQVGQEDLTERLVATSRQYGIEPQQLLAYLQENNQ
                                    :. :**:* :**. .::*.*:*:.***:  *:***::.**:.  * :.::

Mflv_2587|M.gilvum_PYR-GCK          LPAMFADVRRGLTVAAVVYAATVTDTDGTEIDTTEFFGP-----SGDQAA
Mvan_4041|M.vanbaalenii_PYR-1       LPAMFADVRRGLTVAAVVHGATVTDTDGAEIDTAEFFGP-----SGEQAE
MSMEG_4674|M.smegmatis_MC2_155      LPAMFADVRRGLTIAAVVHAATVTDTDGNVIDTMEFFGP-----SGEQAA
MAB_1580|M.abscessus_ATCC_1997      LPGLYVDVRRGKAIAEVIRQAKVTDSTGADVDVDAVLGPRRG--GADEAG
TH_0351|M.thermoresistible__bu      LPVMFADVRRGLAIAAVVHRATVTDTDGNVLDTSEFFGP------REKAE
Rv2462c|M.tuberculosis_H37Rv        LPTMFADVRRELAIRAAVEAATVTDSDGNTIDTSEFFGKR----------
Mb2489c|M.bovis_AF2122/97           LPTMFADVRRELAIRAAVEAATVTDSDGNTIDTSEFFGKR----------
MMAR_3809|M.marinum_M               LPSMFADVRRELAVKAVAQAATVTDTDGNTIDTSEFFGKPPENDVTDLLD
MUL_3732|M.ulcerans_Agy99           LPSMFADVRRELAVKAVAQAATVTDTDGNTIDTSEFFGKPPENDVTDLLD
MLBr_01481|M.leprae_Br4923          LSSLVTDARRRLAVAAVVEAATFTDSDGNTIDTSEFFGKHAQ--------
MAV_1712|M.avium_104                LPAMFADVRRALAIAEVIRAATVTDTAGNTIDTSEFFGKR----------
                                    *. : .*.**  ::  .   *..**: *  :*.  .:*            

Mflv_2587|M.gilvum_PYR-GCK          AQQGAGEDDSEAAVEVSEDTADDASEDDTADDTK--------
Mvan_4041|M.vanbaalenii_PYR-1       AEQ----DEAAPAEDATEETDADS--DEAADDSK--------
MSMEG_4674|M.smegmatis_MC2_155      EDS------AEESTDAAEGEAAED-----ADDTDK-------
MAB_1580|M.abscessus_ATCC_1997      AEAEAAEEKPAKAKKSADSEKTDKSEKAEKKSKKKSKDDDAE
TH_0351|M.thermoresistible__bu      GGETEQAAGSGDAADDAPENAADESPENAADEA---------
Rv2462c|M.tuberculosis_H37Rv        --------VSAG--EAEEAEPADEGAARAASDEATT------
Mb2489c|M.bovis_AF2122/97           --------VSAG--EAEEAEPADEGAARAASDEATT------
MMAR_3809|M.marinum_M               DDADGDAGVDADGDTENSAEPADADSADAAQGAG--------
MUL_3732|M.ulcerans_Agy99           DDADGDAGVDADGDTENSAEPADADSADTAQGAG--------
MLBr_01481|M.leprae_Br4923          --------SDKADQKTEEADPNSDAIDEEVDEAAE-------
MAV_1712|M.avium_104                --------PSGDGAADEDADQADESTTADAGE----------
                                                          .