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TNRWRWVVPLFAVFLAAGCTTTTTGKAGLAPNAVPRPLMGSLIQRVPLDGAALSTLLNQPFQALPPFPPV FGGSDSLGDSDVSARPADCVGVGYLTQRNVYRSVEVKSVARVSWRHDGSSVKVDDVDEGVVALPSAAAAD DLFARFSAQWKECDGTTLTVPASAFGQRSITDVRVADSVVAATVSLRRGTHSILASVPQARAVGVRGNCV VEVAVTFFGITHPSDQGSADISTSAVDIAHAMMDRISELS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2403c | lppR | - | 100% (251) | PROBABLE CONSERVED LIPOPROTEIN LPPR |
| M. tuberculosis H37Rv | Rv1266c | pknH | 2e-07 | 23.95% (238) | transmembrane serine/threonine-protein kinase H |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2426c | lppR | 1e-141 | 99.60% (251) | lipoprotein LppR |
| M. gilvum PYR-GCK | Mflv_2674 | - | 1e-17 | 35.68% (185) | LppR |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0806 | - | 2e-14 | 26.61% (248) | lipoprotein LppR |
| M. marinum M | MMAR_3722 | lppR | 1e-49 | 42.97% (249) | lipoprotein, LppR |
| M. avium 104 | MAV_1779 | - | 5e-52 | 47.90% (238) | LppR protein |
| M. smegmatis MC2 155 | MSMEG_4555 | - | 3e-38 | 38.58% (254) | LppR protein |
| M. thermoresistible (build 8) | TH_2458 | - | 5e-15 | 31.82% (242) | PUTATIVE LppR |
| M. ulcerans Agy99 | MUL_3665 | lppR | 1e-50 | 43.37% (249) | lipoprotein, LppR |
| M. vanbaalenii PYR-1 | Mvan_3879 | - | 2e-15 | 34.24% (184) | LppR |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2403c|M.tuberculosis_H37Rv --MTNRWRWVVPLFAVFLAAGCTT-----TTTGKAGLAPNAVPRPLMGSL
Mb2426c|M.bovis_AF2122/97 --MTNRWRWVVPLFAVFLAAGCTT-----TTTGKAGLAPNAVPRPLMGSL
MAV_1779|M.avium_104 --MRIFTAATLLTAVAALAAGCGG-----VVSGTAKPAPNLKPRPLSGAT
MMAR_3722|M.marinum_M ---MRTRLVLACLLIISLASGCTS-----VVAGTALPAAGLAPQLVTGEA
MUL_3665|M.ulcerans_Agy99 -------MVLACLLAISLASGCTS-----VVAGAALPAAGLAPQLVTGEA
MSMEG_4555|M.smegmatis_MC2_155 --MKTIAKWSVVAASLVLVVGCTR-----IVDGSMQPAADLPPRPLRGAD
Mflv_2674|M.gilvum_PYR-GCK ------------MCLAVTLSGCAG----APVDDRPVVRIVEAAQPSVAIP
Mvan_3879|M.vanbaalenii_PYR-1 MSGKLAAAAAAAACACVALSGCTG----VPADERPVVRIVEAAQPSPAIP
TH_2458|M.thermoresistible__bu --MRRFGATVAVAAVGVCLAGCTVTADPQAAESPPAVRIDPAVVPSESRP
MAB_0806|M.abscessus_ATCC_1997 -MWLRMALWQALLVVVAMLVGCSE-----LVNGRALKPAPPPDPP--ERP
** .
Rv2403c|M.tuberculosis_H37Rv IQRVPLDGAALSTLLNQPFQALPP-FPPVFGGSDSLGD---SDVSARPAD
Mb2426c|M.bovis_AF2122/97 IQRVPLDGAALSTLLNQPFQALPP-FPPVFGGSDSLGD---SDVSARPAD
MAV_1779|M.avium_104 VQQVLLDGPTLSRMLNQPFVARD---PAQVGGPEKLYR---GGRSASQSG
MMAR_3722|M.marinum_M IKDVLLDSAALAKILGQDFTAKSE-LPPRFGGPEKLQE---AFGRVSRVD
MUL_3665|M.ulcerans_Agy99 IKDVLLDSAALAKILGQDFTAKSE-LPPRFGGTERLQE---AFGRVSRVD
MSMEG_4555|M.smegmatis_MC2_155 IARVLPGVDELSEILDQRMVEDIGGRRDVSGGVEDMPDGLATESDATPHD
Mflv_2674|M.gilvum_PYR-GCK LGPFLPTAAELSATLGTGPNALMA--PPVEGDSDVLLSG-VADAHATPAH
Mvan_3879|M.vanbaalenii_PYR-1 LGPFLPTGQELATLLATGPNGLLG--RPVEGDADVLLRS-VADAQVAPAE
TH_2458|M.thermoresistible__bu LAPILPTAEELSDLLGT--AGFTG--PLVDGDADALLAG-ITDAAASPPE
MAB_0806|M.abscessus_ATCC_1997 ITRVLPDQAELSRVLRSPMQARYG---GRPGGVQMLPDG---MAGASLVE
: . *: * *. : : .
Rv2403c|M.tuberculosis_H37Rv CVGVGYLTQRNVYRSV----EVKSVARVSWRHDG----SSVKVDDVDEGV
Mb2426c|M.bovis_AF2122/97 CVGVGYLTQRNVYRSV----EVKSVARVSWRHDG----SSVKVDDLDEGV
MAV_1779|M.avium_104 CLGVTAMLQKSVYPAA----DVRDVAAESWWNNG----ELAQVITVMEGV
MMAR_3722|M.marinum_M CLGITTMLAKSAYQSARRSGSVENVARETWWNSA----GPAKVISVAEGV
MUL_3665|M.ulcerans_Agy99 CLGITTMLAKSAYQSARRSGSVENVARETWWNSA----GPAKVISVAEGV
MSMEG_4555|M.smegmatis_MC2_155 CVGTTSAMQRSVYESA----DVTEVISEGFDGDE----DGGAVLAANVGV
Mflv_2674|M.gilvum_PYR-GCK CVSAAYRLQEIVYDDS----PVHSVASSTWAGGA----FDGPPVSGFFGV
Mvan_3879|M.vanbaalenii_PYR-1 CVSAAYRMQEIVYDTS----PVQSVASNTWAGGG----FDGPPVSGFFGV
TH_2458|M.thermoresistible__bu CVGPAYRLQKSVYGTG----PVRGVASRSWAGGS----GEQPTMSGFFGV
MAB_0806|M.abscessus_ATCC_1997 CIKVHAPVMRHTYEQA----PVHAATRITWNTERGHMQFPAPDLRTTFGV
*: . .* * . : **
Rv2403c|M.tuberculosis_H37Rv VALPSAAAADDLFARFSAQWKECDGTTLTVPASAF---GQR-SITDVRVA
Mb2426c|M.bovis_AF2122/97 VALPSAAAADDLFARFSAQWKECDGTTLTVPASAF---GQR-SITDVRVA
MAV_1779|M.avium_104 VTLPSAAQAQALFAQFSRQWQQCNGMTTSEQSGPI---STTNVISDVRAT
MMAR_3722|M.marinum_M VALSGPDEAAELFESFTQQWDSCDGAMVTIDSGKV---AFADKITDVRIT
MUL_3665|M.ulcerans_Agy99 VALSGPDEAAELFESFTQQWDSCDGAMVTIDSGKV---AFADKITDVRIT
MSMEG_4555|M.smegmatis_MC2_155 VALDSVASANKLFDAFAEQWQDCDGTTVTIVKEPVRGGFFTDHVTDVRVE
Mflv_2674|M.gilvum_PYR-GCK VQMASPAAAQEFFAATTEQWRHCNSQTVALQSPERGVGELS-RITDVTFD
Mvan_3879|M.vanbaalenii_PYR-1 VQMTDPGAAQEFFASLTDQWRRCNGQTVSLQSPDHGAGEMS-RITGVAFD
TH_2458|M.thermoresistible__bu VRFATPTDAEAFFAAAADTWYRCNGQTLVLD---QRGGGAS-RITGVTVD
MAB_0806|M.abscessus_ATCC_1997 IELDTSDSARSWYRRLAADWRRCEGKTAVIVRANY---TLRYDIGPISDA
: : * : : * *:. : :
Rv2403c|M.tuberculosis_H37Rv DSVVAATVSLRRGTHSILAS--VPQARAVGVRGNCVVEVAVTFFGITHP-
Mb2426c|M.bovis_AF2122/97 DSVVAATVSLRRGTHSILAS--VPQARAVGVRGNCVVEVAVTFFGITHP-
MAV_1779|M.avium_104 DTTVAATKTATAVLPNMPALRPTPQGRALGVRSNCLVEVEVVFFGGRRS-
MMAR_3722|M.marinum_M NSVLAATVSIGTRISGSQLKAARPEARAIGLRGNCLVEVEIAFFSVRGP-
MUL_3665|M.ulcerans_Agy99 NSVLAATVSIGTRISGSQLKAARPEARAIGLRGNCLVEVEIAFFSVRGP-
MSMEG_4555|M.smegmatis_MC2_155 NSVVAATVEFGHTLDS----LITPVARALGVRANCLVEVDVAYYSEPES-
Mflv_2674|M.gilvum_PYR-GCK ERVVSASVLHTSAGTAS-----PTAMRALGLAGDCIVEVELTD-------
Mvan_3879|M.vanbaalenii_PYR-1 QRVVSAHVLHASGGTES-----PTGMRAVGLAGDCIVEVELID-------
TH_2458|M.thermoresistible__bu HAGEHAVVSAVVMRDTG-----TAMQRALGVARDYVVDIEITDGEITDEL
MAB_0806|M.abscessus_ATCC_1997 GDLMTTVLMFSGTGSSRP----MPVQRALAQVSRYLIDVEIMDFADLKH-
: . **:. :::: :
Rv2403c|M.tuberculosis_H37Rv SDQGSADISTSAVDIAHAMMDRISELS--
Mb2426c|M.bovis_AF2122/97 SDQGSADISTSAVDIAHAMMDRISELS--
MAV_1779|M.avium_104 SDPGSADLNTSALDIAHAMMDRVSALG--
MMAR_3722|M.marinum_M ADKGSADINTSAIEIAHAMMERVSNMS--
MUL_3665|M.ulcerans_Agy99 ADKGSADINTSAIEIAHAMMERVSNMS--
MSMEG_4555|M.smegmatis_MC2_155 RQKGNTDVDAVAIDIAHEMMDEISDLT--
Mflv_2674|M.gilvum_PYR-GCK --PRAEGPPRGAVAVADVILDKIAASR--
Mvan_3879|M.vanbaalenii_PYR-1 --PRAAADGRSAVAVADAILDKIAAVR--
TH_2458|M.thermoresistible__bu TGGAAAGDTRGAVAVADLMLRKIG-----
MAB_0806|M.abscessus_ATCC_1997 --PAEPGITDKAEAIAQLITDQINAGGDI
* :*. : .: