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MSIAEDITQLIGRTPLVRLRRVTDGAVADIVAKLEFFNPANSVKDRIGVAMLQAAEQAGLIKPDTIILEP TSGNTGIALAMVCAARGYRCVLTMPETMSLERRMLLRAYGAELILTPGADGMSGAIAKAEELAKTDQRYF VPQQFENPANPAIHRVTTAEEVWRDTDGKVDIVVAGVGTGGTITGVAQVIKERKPSARFVAVEPAASPVL SGGQKGPHPIQGIGAGFVPPVLDQDLVDEIITVGNEDALNVARRLAREEGLLVGISSGAATVAALQVARR PENAGKLIVVVLPDFGERYLSTPLFADVAD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2334 | cysK1 | - | 100% (310) | PROBABLE CYSTEINE SYNTHASE A CYSK1 (O-ACETYLSERINE SULFHYDRYLASE A) (O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A) |
| M. tuberculosis H37Rv | Rv1077 | cbs | 7e-69 | 46.58% (307) | cystathionine beta-synthase CBS (Serine sulfhydrase) |
| M. tuberculosis H37Rv | Rv1336 | cysM | 3e-53 | 38.56% (319) | cysteine synthase B CysM |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2362 | cysK1 | 1e-173 | 100.00% (310) | cysteine synthase A CysK1 |
| M. gilvum PYR-GCK | Mflv_2043 | - | 2e-68 | 45.25% (305) | cystathionine beta-synthase |
| M. leprae Br4923 | MLBr_00839 | cysK | 1e-153 | 85.81% (310) | putative cysteine synthase |
| M. abscessus ATCC 19977 | MAB_1195 | - | 1e-70 | 45.95% (309) | cystathionine beta-synthase |
| M. marinum M | MMAR_3645 | cysK1 | 1e-151 | 85.48% (310) | cysteine synthase a CysK1 |
| M. avium 104 | MAV_2052 | cysK | 1e-156 | 88.39% (310) | cysteine synthase A |
| M. smegmatis MC2 155 | MSMEG_5270 | - | 6e-66 | 44.26% (305) | cystathionine beta-synthase |
| M. thermoresistible (build 8) | TH_1449 | cysK | 1e-115 | 63.75% (309) | PROBABLE CYSTEINE SYNTHASE A CYSK1 (O-ACETYLSERINE |
| M. ulcerans Agy99 | MUL_1465 | cysK1 | 1e-150 | 84.84% (310) | cysteine synthase a CysK1 |
| M. vanbaalenii PYR-1 | Mvan_4674 | - | 6e-68 | 44.92% (305) | cystathionine beta-synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2334|M.tuberculosis_H37Rv MS-IAEDITQLIGRTPLVRLRRVTDGAVADIVAKLEFFNPANSVKDRIGV
Mb2362|M.bovis_AF2122/97 MS-IAEDITQLIGRTPLVRLRRVTDGAVADIVAKLEFFNPANSVKDRIGV
MAV_2052|M.avium_104 MS-IAENVTQLIGNTPLVRLNRVTEGAVADVVAKLEFFNPGNSVKDRIGV
MLBr_00839|M.leprae_Br4923 MS-IAEDVTQLVGNTPLVRLRRVTEGALADVVAKLESFNPANSVKDRIGV
MMAR_3645|M.marinum_M MT-IAENITQLIGGTPLVRLRRVTDGAAADVVAKLESFNPAGSIKDRIGV
MUL_1465|M.ulcerans_Agy99 MT-IAENIAQLIGGTPLVRLRRVTDGAAADVVAKLESFNPAGSIKDRIGV
TH_1449|M.thermoresistible__bu MGNIYNDVTEIVGRTPLVRLNRLTEGLDAQVLAKLEFYNPANSVKDRIGV
Mflv_2043|M.gilvum_PYR-GCK MR-IARHISELIGNTPLVQLNSVVPPGAGTVVAKVEYLNPGGSSKDRIAI
Mvan_4674|M.vanbaalenii_PYR-1 MR-IARHISELIGNTPLVQLNSVVPPGAGTVAAKIEYLNPGGSSKDRIAI
MSMEG_5270|M.smegmatis_MC2_155 MR-IARHISELIGNTPLVQLNSVVPEGAGLVAAKIEYLNPGGSSKDRIAL
MAB_1195|M.abscessus_ATCC_1997 MR-IAQHVSDLIGNTPLVRLNSVVPEGCATVAAKIEYLNPGGSSKDRIAV
* * ..:::::* ****:*. :. . : **:* **..* ****.:
Rv2334|M.tuberculosis_H37Rv AMLQAAEQAGLIKPDTIILEPTSGNTGIALAMVCAARGYRCVLTMPETMS
Mb2362|M.bovis_AF2122/97 AMLQAAEQAGLIKPDTIILEPTSGNTGIALAMVCAARGYRCVLTMPETMS
MAV_2052|M.avium_104 AMIDAAEQAGLIKPDTIILEPTSGNTGIALALVAAARGYRCVLTMPETMS
MLBr_00839|M.leprae_Br4923 AMIDTAEEAGLIKPDTVILEPTSGNTGIALAMVCAARGYHCVLTMPETMS
MMAR_3645|M.marinum_M AMIDAAEKAGLIKPDTIILEPTSGNTGIALAMVSAARGYKCVLTMPDTMS
MUL_1465|M.ulcerans_Agy99 AMIDAAEKAGLIKPDTIILEPTSGNTGIALAMVSAARGYKCVLTMPDTMS
TH_1449|M.thermoresistible__bu AIVDAAEASGALKPGGTIVEATSGNTGIALAMVGAARGYRVILTMPDTMS
Mflv_2043|M.gilvum_PYR-GCK KMIDAAEASGELKPGGTIVEPTSGNTGVGLAIVAQQRGYKCIFVCPDKVS
Mvan_4674|M.vanbaalenii_PYR-1 KMIDAAEASGELKPGGTIVEPTSGNTGVGLAIVAQQRGYKCIFVCPDKVS
MSMEG_5270|M.smegmatis_MC2_155 KMIEAAEVSGELKPGGTIVEPTSGNTGVGLALVAQQRGYKCVFVCPDKVS
MAB_1195|M.abscessus_ATCC_1997 KMIEAAEEAGLLKPGGTIVEPTSGNTGVGLALVAQRKGYHCVFVCPDKVS
::::** :* :**. *:*.******:.**:* :**: ::. *:.:*
Rv2334|M.tuberculosis_H37Rv LERRMLLRAYGAELILTPGADG---MSGAIAKAEELAKTDQRYFVPQQFE
Mb2362|M.bovis_AF2122/97 LERRMLLRAYGAELILTPGADG---MSGAIAKAEELAKTDQRYFVPQQFE
MAV_2052|M.avium_104 VERRMLLRALGAEIVLTPGADG---MPGAIAKAEELAKSDDRYFVPQQFE
MLBr_00839|M.leprae_Br4923 IERRMLLRAYGAELILTPGADG---MSGAIAKAEELAKSDKRYFIPQQFE
MMAR_3645|M.marinum_M IERRMLLRAYGAELVLTPGAEG---MAGAIAKAEELAKTDDRYFIPQQFE
MUL_1465|M.ulcerans_Agy99 IERRMLLRAYGAELVLTPGAEG---MAGAIAKAEELAKTDDRYFIPQQFE
TH_1449|M.thermoresistible__bu VERRVMLRAFGAEIVLTPGAEG---MAGAVARAEQILAETENAVAAKQFA
Mflv_2043|M.gilvum_PYR-GCK EDKQNVLRAYGAEVVVCPTAVAPDDPASYYSVSNRLVSEIDGAWKPDQYS
Mvan_4674|M.vanbaalenii_PYR-1 EDKQNVLRAYGADVVVCPTAVAPEDPASYYSVSNRLVEEIDGAWKPDQYS
MSMEG_5270|M.smegmatis_MC2_155 EDKRNVLRAYGAEVVVCPTAVPPDHPDSYYSVSNRLVTEIEGAWKPDQYS
MAB_1195|M.abscessus_ATCC_1997 EDKRNVLRAYGAEVVVCPTAVPPEHPDSYYNVSDRLVREIEGAWKPDQYS
::: :*** **:::: * * . ::.: . ..*:
Rv2334|M.tuberculosis_H37Rv NPANPAIHRVTTAEEVWRDTDGKVDIVVAGVGTGGTITGVAQVIKERKPS
Mb2362|M.bovis_AF2122/97 NPANPAIHRVTTAEEVWRDTDGKVDIVVAGVGTGGTITGVAQVIKERKPS
MAV_2052|M.avium_104 NPANPAIHRSTTAEEVWRDTDGKVDIFVAGVGTGGTITGVAQVIKERKPS
MLBr_00839|M.leprae_Br4923 NPANPAIHAATTAEEVWRDTDGKVDIFVSGIGTGGTITGVARIIKERRPA
MMAR_3645|M.marinum_M NPANPAVHAVTTAEEVWRDTDGKVDIFVSGVGTGGTITGVAQVIKQRRPS
MUL_1465|M.ulcerans_Agy99 NPANPAVHAVTTAEEVWRDTDGKVDIFVSGVGTGGTITGVAQVIKQRRPS
TH_1449|M.thermoresistible__bu NPANPDIHERTTGEEVWADTDGTVDIFVAGIGTGGTLTGVGRLLKSRKPG
Mflv_2043|M.gilvum_PYR-GCK NPMGPESHYETTGPEIWADTDGKITHFVAGVGTGGTITGAGRYLKEVSGG
Mvan_4674|M.vanbaalenii_PYR-1 NPMGPESHYETTGPEIWADTDGKVTHFVAGVGTGGTITGAGRYLKEVSGG
MSMEG_5270|M.smegmatis_MC2_155 NQMGPESHYETTGPEIWADTEGKITHFVAGVGTGGTITGTGRYLKEVSGG
MAB_1195|M.abscessus_ATCC_1997 NPNGPASHYETTGPEIWADTDGKITHFVAGVGTGGTITGAGRYLKEVSGG
* .* * **. *:* **:*.: .*:*:*****:**..: :*. .
Rv2334|M.tuberculosis_H37Rv A-----RFVAVEPAASPVLSGGQKGPHPIQGIGAGFVPPVLDQDLVDEII
Mb2362|M.bovis_AF2122/97 A-----RFVAVEPAASPVLSGGQKGPHPIQGIGAGFVPPVLDQDLVDEII
MAV_2052|M.avium_104 A-----QFIAVEPAASPVLSGGQKGPHPIQGLGAGFVPPVLAMDLVDEVI
MLBr_00839|M.leprae_Br4923 T-----QFVAVEPAASPVLSGGQKGPHPIQGIGAGFVPSVLVLDLVDEIV
MMAR_3645|M.marinum_M A-----QFVAVEPAASPVLSGGQKGPHPIQGIGAGFVPPVLDLALVDEVI
MUL_1465|M.ulcerans_Agy99 A-----QFVAVEPAASPVLSGGQKGPHPIQGIGAGFVPPVLDLALVDEVI
TH_1449|M.thermoresistible__bu V-----KIVGVEPLDSPILNGGQPGPHKIQGIGANFIPEVLDRDVYDEII
Mflv_2043|M.gilvum_PYR-GCK R----VKVIGADPEGS-VYSGGTGRPYLVEGVGEDFWPSAYDPSVPDEII
Mvan_4674|M.vanbaalenii_PYR-1 R----VKVIGVDPEGS-VYSGGTGRPYLVEGVGEDFWPAAYDPSVPDEII
MSMEG_5270|M.smegmatis_MC2_155 K----VKVIGADPEGS-VYSGGTGRPYLVEGVGEDFWPTAYDPSVPDEII
MAB_1195|M.abscessus_ATCC_1997 RAIGEVKIVGADPEGS-VYSGGTGRPYLVEGVGEDFWPSAYDPSVVDEVI
:.:..:* * : .** *: ::*:* .* * . : **::
Rv2334|M.tuberculosis_H37Rv TVGNEDALNVARRLAREEGLLVGISSGAATVAALQVARRPENAGKLIVVV
Mb2362|M.bovis_AF2122/97 TVGNEDALNVARRLAREEGLLVGISSGAATVAALQVARRPENAGKLIVVV
MAV_2052|M.avium_104 AVGNEESIALARRLAAEEGLLVGISSGAALVAALQVARRPENAGKLVVVV
MLBr_00839|M.leprae_Br4923 TVGNEEALDLARRLAKEEGLLVGISAGAAVCAALHVARRPENTGKLIVVV
MMAR_3645|M.marinum_M TVGNDDALELARRMATEEGLLVGISSGAAVWAARELAHRPENAGKLIVVV
MUL_1465|M.ulcerans_Agy99 TVGNDDALELARRMATEEGLLFGISSGAAVWAARELAHRPENAGKLIVVV
TH_1449|M.thermoresistible__bu DAGFEDAISVSRALATQEGILGGISAGANVWAALEVAKRPENAGKVIVVV
Mflv_2043|M.gilvum_PYR-GCK AVSDADSFDMTRRLAREEALLVGGSCGMAAVAAIRVAER-EGPDALVVVL
Mvan_4674|M.vanbaalenii_PYR-1 AVSDADSFDMTRRLAREEALLVGGSCGMAAVAAIKVAER-EGPDALVVVL
MSMEG_5270|M.smegmatis_MC2_155 AVSDADSFEMTRRLAREEALLVGGSCGMAVVAAIEVARK-AGPDAVVVVL
MAB_1195|M.abscessus_ATCC_1997 AVSDADSFEMTRRLAREEGLLVGGSCGMAVVAAIRLAEK-VGPDGLVVVL
.. ::: ::* :* :*.:* * *.* ** .:*.: ... ::**:
Rv2334|M.tuberculosis_H37Rv LPDFGERYLSTPLFADVAD-------------------------------
Mb2362|M.bovis_AF2122/97 LPDFGERYLSTPLFADVAD-------------------------------
MAV_2052|M.avium_104 LPDFGERYLSTPLFADLAD-------------------------------
MLBr_00839|M.leprae_Br4923 LPDFGERYLSTMLFADLAN-------------------------------
MMAR_3645|M.marinum_M LPDFGERYLSTVLFADLSE-------------------------------
MUL_1465|M.ulcerans_Agy99 LPDFGERYLSTVLFADLSE-------------------------------
TH_1449|M.thermoresistible__bu IPDFGERYVSTALFEHIRD-------------------------------
Mflv_2043|M.gilvum_PYR-GCK LPDGGRGYLSKIFNDGWMSSYGFLRTRLDGSVQESTVGDVLRGKSGALPA
Mvan_4674|M.vanbaalenii_PYR-1 LPDGGRGYLSKIFNDAWMSSYGFLRSRLDGSVEESTVGDVLRGKSGALPD
MSMEG_5270|M.smegmatis_MC2_155 LPDGGRGYLSKIFNDAWMSSYGFLRTRLDGSVEK-TVGDVLRGKSGALPD
MAB_1195|M.abscessus_ATCC_1997 LPDGGRGYLSKVFNDAWMSSYGFLRSRLDGSVSEPTVGDVLRGKSGALPD
:** *. *:*. : .
Rv2334|M.tuberculosis_H37Rv --------------------------------------------------
Mb2362|M.bovis_AF2122/97 --------------------------------------------------
MAV_2052|M.avium_104 --------------------------------------------------
MLBr_00839|M.leprae_Br4923 --------------------------------------------------
MMAR_3645|M.marinum_M --------------------------------------------------
MUL_1465|M.ulcerans_Agy99 --------------------------------------------------
TH_1449|M.thermoresistible__bu --------------------------------------------------
Mflv_2043|M.gilvum_PYR-GCK LVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERDLVS
Mvan_4674|M.vanbaalenii_PYR-1 LVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLS
MSMEG_5270|M.smegmatis_MC2_155 LVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLS
MAB_1195|M.abscessus_ATCC_1997 LVHTHPSETVRDAIEILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLS
Rv2334|M.tuberculosis_H37Rv --------------------------------------------------
Mb2362|M.bovis_AF2122/97 --------------------------------------------------
MAV_2052|M.avium_104 --------------------------------------------------
MLBr_00839|M.leprae_Br4923 --------------------------------------------------
MMAR_3645|M.marinum_M --------------------------------------------------
MUL_1465|M.ulcerans_Agy99 --------------------------------------------------
TH_1449|M.thermoresistible__bu --------------------------------------------------
Mflv_2043|M.gilvum_PYR-GCK AVFEGRAKLADAVAQHMSPPLPLIGAGELVSAAAKTLRECDAVMVVEEGK
Mvan_4674|M.vanbaalenii_PYR-1 AVFEGRAKLADAVADHMGPPLPLIGVGELVSTAAKALRESDAVMVVEEGK
MSMEG_5270|M.smegmatis_MC2_155 AVFEGRAKLADAVAEHMSPPLPLIGAGELVSTAAKTLRESDAVMVVEDGK
MAB_1195|M.abscessus_ATCC_1997 AVFEGRAQLADAVAQHMSPPLPLVGSGEPLSTAGSMLRDTDAVMVVDEGK
Rv2334|M.tuberculosis_H37Rv ----------------------
Mb2362|M.bovis_AF2122/97 ----------------------
MAV_2052|M.avium_104 ----------------------
MLBr_00839|M.leprae_Br4923 ----------------------
MMAR_3645|M.marinum_M ----------------------
MUL_1465|M.ulcerans_Agy99 ----------------------
TH_1449|M.thermoresistible__bu ----------------------
Mflv_2043|M.gilvum_PYR-GCK PAGVLTRHDLLGYLSDS-SPGH
Mvan_4674|M.vanbaalenii_PYR-1 PVGVLTRHDLLGYLSEG-NARR
MSMEG_5270|M.smegmatis_MC2_155 PVGVLTRHDLLGFLSEG-GYRH
MAB_1195|M.abscessus_ATCC_1997 PVGVITRHDLLGFVSSGRGVRH