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MSVAAEGRRLLRLEVRNAQTPIERKPPWIKTRARIGPEYTELKNLVRREGLHTVCEEAGCPNIFECWEDR EATFLIGGDQCTRRCDFCQIDTGKPAELDRDEPRRVADSVRTMGLRYATVTGVARDDLPDGGAWLYAATV RAIKELNPSTGVELLIPDFNGEPTRLAEVFESGPEVLAHNVETVPRIFKRIRPAFTYRRSLGVLTAARDA GLVTKSNLILGLGETSDEVRTALGDLRDAGCDIVTITQYLRPSARHHPVERWVKPEEFVQFARFAEGLGF AGVLAGPLVRSSYRAGRLYEQARNSRALASR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2218 | lipA | - | 100% (311) | lipoyl synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2241 | lipA | 0.0 | 100.00% (311) | lipoyl synthase |
| M. gilvum PYR-GCK | Mflv_2932 | - | 1e-149 | 81.29% (310) | lipoyl synthase |
| M. leprae Br4923 | MLBr_00858 | lipA | 1e-159 | 86.45% (310) | lipoyl synthase |
| M. abscessus ATCC 19977 | MAB_1942c | - | 1e-146 | 82.15% (297) | lipoyl synthase |
| M. marinum M | MMAR_3286 | lipA | 1e-159 | 88.45% (303) | lipoate biosynthesis protein a LipA |
| M. avium 104 | MAV_2270 | lipA | 1e-163 | 90.88% (307) | lipoyl synthase |
| M. smegmatis MC2 155 | MSMEG_4286 | lipA | 1e-154 | 84.64% (306) | lipoyl synthase |
| M. thermoresistible (build 8) | TH_0219 | lipA | 1e-152 | 84.64% (306) | Probable lipoate biosynthesis protein A LipA |
| M. ulcerans Agy99 | MUL_1343 | lipA | 1e-159 | 88.45% (303) | lipoyl synthase |
| M. vanbaalenii PYR-1 | Mvan_0914 | - | 1e-151 | 84.49% (303) | lipoyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2218|M.tuberculosis_H37Rv MSVAAE----------GRRLLRLEVRNAQTPIERKPPWIKTRARIGPEYT
Mb2241|M.bovis_AF2122/97 MSVAAE----------GRRLLRLEVRNAQTPIERKPPWIKTRARIGPEYT
MAV_2270|M.avium_104 MTVAPE----------GRKLLRLEVRNADTPIERKPPWIRVRARMGPEYT
MLBr_00858|M.leprae_Br4923 MTVAPE----------DCRLLRLEVRNAQTPIERKPPWIKTRARMGPEYT
MMAR_3286|M.marinum_M MNVAPEPGAAGAAAPQGRKLLRLEVRNAQTPIERKPPWIRTRARMGPEYT
MUL_1343|M.ulcerans_Agy99 MNVAPEPGAAGAAAPQGRKLLRLEVRNAQTPIERKPPWIRTRARMGPEYT
Mflv_2932|M.gilvum_PYR-GCK MSIAPD----------GRKLLRLEVRNAETPIERKPPWIKTRAKMGPEYK
Mvan_0914|M.vanbaalenii_PYR-1 MTVAPE----------GRRLLRLEVRNAETPIERKPPWIKIRAKMGPEYK
TH_0219|M.thermoresistible__bu VTVTPE----------GRKLLRLEVRNAQTPIERKPPWIKTRATMGPEYR
MSMEG_4286|M.smegmatis_MC2_155 MTVVPE----------GRKLLRLEVRNAQTPIERKPPWIKTRAKMGPEYT
MAB_1942c|M.abscessus_ATCC_199 ---MTE----------PRKLLRLEVRNAQTPIERKPDWIRTRAKMGPEYK
.: :*********:******* **: ** :****
Rv2218|M.tuberculosis_H37Rv ELKNLVRREGLHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQI
Mb2241|M.bovis_AF2122/97 ELKNLVRREGLHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQI
MAV_2270|M.avium_104 ELKSLVRREGLHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQI
MLBr_00858|M.leprae_Br4923 ALKNLVRRVALHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQI
MMAR_3286|M.marinum_M ELKNLVRREGLHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQI
MUL_1343|M.ulcerans_Agy99 ELKNLVRREGLHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQI
Mflv_2932|M.gilvum_PYR-GCK ELKALVRREGLHTVCEEAGCPNIFECWEDREATFLIGGEQCTRRCDFCQI
Mvan_0914|M.vanbaalenii_PYR-1 ELKGLVRREGLHTVCEEAGCPNIFECWEDREATFLIGGEQCTRRCDFCQI
TH_0219|M.thermoresistible__bu DLKALVRREGLHTVCEEAGCPNIFECWEDREATFLIGGEQCTRRCDFCQI
MSMEG_4286|M.smegmatis_MC2_155 ELKGLVRREGLHTVCEEAGCPNIFECWEDREATFLIGGEQCTRRCDFCQI
MAB_1942c|M.abscessus_ATCC_199 ELKSLVRSGGLHTVCEEAGCPNIFECWEDREATFLIGGEQCTRRCDFCQI
** *** .****************************:***********
Rv2218|M.tuberculosis_H37Rv DTGKPAELDRDEPRRVADSVRTMGLRYATVTGVARDDLPDGGAWLYAATV
Mb2241|M.bovis_AF2122/97 DTGKPAELDRDEPRRVADSVRTMGLRYATVTGVARDDLPDGGAWLYAATV
MAV_2270|M.avium_104 DTGKPAELDRDEPRRVADSVRTMGLRYATVTGVARDDLPDGGAWLYAETV
MLBr_00858|M.leprae_Br4923 DTGKPAALDRDEPRRVAESVQTMGLRYTTVTGVARDDLPDGGAWLYATTV
MMAR_3286|M.marinum_M DTGKPAPLDRDEPRRVAESVHTMGLRYATVTGVARDDLPDGGAWLYAETV
MUL_1343|M.ulcerans_Agy99 DTGKPAPLDRDEPRRVAESVHTMGLRYATVTGVARDDLPDGGAWLYAETV
Mflv_2932|M.gilvum_PYR-GCK DTGKPADLDRDEPRRVAESVQAMGLRYSTVTGVARDDLPDGGAWLYAETV
Mvan_0914|M.vanbaalenii_PYR-1 DTGKPAELDRDEPRRVAESVAAMGLRYSTVTGVARDDLPDGGAWLYSETV
TH_0219|M.thermoresistible__bu DTGKPAELDTDEPRRVAESVHAMGLRYSTVTGVARDDLPDGGAWLYAETV
MSMEG_4286|M.smegmatis_MC2_155 DTGKPADLDRDEPRRVAESVQAMGLRYSTVTGVARDDLPDGGAWLYAETV
MAB_1942c|M.abscessus_ATCC_199 DTGKPADLDRDEPRRVAESVHTMGLRYSTVTGVARDDLPDGGAWLYAETV
****** ** *******:** :*****:******************: **
Rv2218|M.tuberculosis_H37Rv RAIKELNPSTGVELLIPDFNGEPTRLAEVFESGPEVLAHNVETVPRIFKR
Mb2241|M.bovis_AF2122/97 RAIKELNPSTGVELLIPDFNGEPTRLAEVFESGPEVLAHNVETVPRIFKR
MAV_2270|M.avium_104 RAIKELNPSTGVELLIPDFNGRPDRLAEVFGSRPEVLAHNVETVPRIFKR
MLBr_00858|M.leprae_Br4923 RAIKELNPSTGVELLIPDFNGQPARLAEVFDSRPQVLAHNVETVPRIFKR
MMAR_3286|M.marinum_M RAIKELNPSTGVELLIPDFNGKADQLGEVFEARPEVLAHNVETVPRVFKR
MUL_1343|M.ulcerans_Agy99 RAIKELNPSTGVELLIPDFNGKADQLGEVFEARPEVLAHNVETVPRVFKR
Mflv_2932|M.gilvum_PYR-GCK RQIKALNPNTGVELLIPDFNADPDQLRAVFESRPEVLAHNVETVPRIFKR
Mvan_0914|M.vanbaalenii_PYR-1 RQIKALNPNTGVELLIPDFNADPAQLQQVFESRPEVLAHNVETVPRIFKR
TH_0219|M.thermoresistible__bu RAIKALNPNTGVELLIPDFNGDPELLEQVFETRPEVLAHNVETVPRIFKR
MSMEG_4286|M.smegmatis_MC2_155 RYIKRLNPNTGVELLIPDFNGNPEQLEEVFESRPEVLAHNVETVPRIFKR
MAB_1942c|M.abscessus_ATCC_199 RYIKDLNPATGVELLIPDFNAIPAQLDEVFASRPEVLAHNLETVPRVFRR
* ** *** ***********. . * ** : *:*****:*****:*:*
Rv2218|M.tuberculosis_H37Rv IRPAFTYRRSLGVLTAARDAGLVTKSNLILGLGETSDEVRTALGDLRDAG
Mb2241|M.bovis_AF2122/97 IRPAFTYRRSLGVLTAARDAGLVTKSNLILGLGETSDEVRTALGDLRDAG
MAV_2270|M.avium_104 IRPAFTYRRSLDVLTAAREAGLVTKSNLILGLGETPDEVRTALADLRGAG
MLBr_00858|M.leprae_Br4923 IRPAFTYQRSLDVLTAAREAGLVTKSNLILGLGETADEVRTALADLRKTG
MMAR_3286|M.marinum_M IRPAFTYQRSLDVLTAARQFGLVTKSNLILGMGETPEEVRTALVDLHDAG
MUL_1343|M.ulcerans_Agy99 IRPAFTYQRSLDVLTAARQFGLVTKSNLILGMGETPEEVRTALVDLHDAG
Mflv_2932|M.gilvum_PYR-GCK IRPGFRYERSLAVITAARDYGLVTKSNLILGMGETPEEVRAALHDLHDAG
Mvan_0914|M.vanbaalenii_PYR-1 IRPGFRYERSLSVLTMARDYGLVTKSNLILGMGETPEEVREALVDLHQAG
TH_0219|M.thermoresistible__bu IRPAFRYDRSLAVLTAARDYGLVTKSNLILGLGETPDEVRTALRDLHEAG
MSMEG_4286|M.smegmatis_MC2_155 IRPAFRYDRSLAVITAARNFGLVTKSNLILGMGETIDEVRTALRDLHDAG
MAB_1942c|M.abscessus_ATCC_199 IRPAFSYERSLSVITAAREAQLVTKSNLILGMGETNDEIREALVALHEAG
***.* * *** *:* **: **********:*** :*:* ** *: :*
Rv2218|M.tuberculosis_H37Rv CDIVTITQYLRPSARHHPVERWVKPEEFVQFARFAEGLGFAGVLAGPLVR
Mb2241|M.bovis_AF2122/97 CDIVTITQYLRPSARHHPVERWVKPEEFVQFARFAEGLGFAGVLAGPLVR
MAV_2270|M.avium_104 CDIITITQYLRPSARHHPVERWVKPEEFVEFARHAEELGFSGVLAGPLVR
MLBr_00858|M.leprae_Br4923 CDIVTITQYLRPSMRHHPVERWVRPEEFVEYTQYAEGLGFSGVLGGPLVR
MMAR_3286|M.marinum_M CDIITITQYLRPSPRHHPVERWVRPEEFVEFAQYAEGLGFAGVLAGPLVR
MUL_1343|M.ulcerans_Agy99 CDIITITQYLRPSPRHHPVERWVRPEEFVEFAQYAEGLGFAGVLAGPLVR
Mflv_2932|M.gilvum_PYR-GCK CDIVTITQYLRPSPRHHPVERWVHPDEFVDHERYATEIGFAGVLAGPLVR
Mvan_0914|M.vanbaalenii_PYR-1 CDIVTITQYLRPSARHHPVERWVHPDEFVEHERYATGLGFAGVLAGPLVR
TH_0219|M.thermoresistible__bu CDIVTITQYLRPSPRHHPVERWVHPDEFVEYEQFARELGFAGVLAGPLVR
MSMEG_4286|M.smegmatis_MC2_155 CDIITITQYLRPSPRHHPVERWVHPDEFVELSAYAEGLGFAGVLAGPLVR
MAB_1942c|M.abscessus_ATCC_199 CDIITITQYLRPSPRHHPVDRWVKPQEFVELSEFAEGLGFAGVMAGPLVR
***:********* *****:***:*:***: .* :**:**:.*****
Rv2218|M.tuberculosis_H37Rv SSYRAGRLYEQARNSR------------ALASR---------
Mb2241|M.bovis_AF2122/97 SSYRAGRLYEQARNSR------------ALASR---------
MAV_2270|M.avium_104 SSYRAGRLYRQAARAR------------A-------------
MLBr_00858|M.leprae_Br4923 SSYRAGRLYEQAAGTR------------TVGTSVSR------
MMAR_3286|M.marinum_M SSYRAGRLYEQARSRN------------TSGASNSG------
MUL_1343|M.ulcerans_Agy99 SSYRAGRLYEQARSRN------------TSGASNSG------
Mflv_2932|M.gilvum_PYR-GCK SSYRAGKLYAQTVAKR------------SAVSLSNGEIA---
Mvan_0914|M.vanbaalenii_PYR-1 SSYRAGKLYRQARTQP--------------------------
TH_0219|M.thermoresistible__bu SSYRAGRLYAQVAQSR------------PPVS----------
MSMEG_4286|M.smegmatis_MC2_155 SSYRAGKLYAQAARVR------------FADQPPVS------
MAB_1942c|M.abscessus_ATCC_199 SSYRAGRLYAQAMAHHGRPLPAALEHLATAGSARQEAINLIG
******:** *.