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M. tuberculosis H37Rv Rv2101 (helZ)

annotation: PROBABLE HELICASE HELZ
coordinates: 2360240 - 2363281
length: 1013

MLVLHGFWSNSGGMRLWAEDSDLLVKSPSQALRSARPHPFAAPADLIAGIHPGKPATAVLLLPSLRSAPL
DSPELIRLAPRPAARTDPMLLAWTVPVVDLDPTAALAAFDQPAPDVRYGASVDYLAELAVFARELVERGR
VLPQLRRDTHGAAACWRPVLQGRDVVAMTSLVSAMPPVCRAEVGGHDPHELATSALDAMVDAAVRAALSP
MDLLPPRRGRSKRHRAVEAWLTALTCPDGRFDAEPDELDALAEALRPWDDVGIGTVGPARATFRLSEVET
ENEETPAGSLWRLEFLLQSTQDPSLLVPAEQAWNDDGSLRRWLDRPQELLLTELGRASRIFPELVPALRT
ACPSGLELDADGAYRFLSGTAAVLDEAGFGVLLPSWWDRRRKLGLVLSAYTPVDGVVGKASKFGREQLVE
FRWELAVGDDPLSEEEIAALTETKSPLIRLRGQWVALDTEQMRRGLEFLERKPTGRKTTAEILALAASHP
DDVDTPLEVTAVRADGWLGDLLAGAAAASLQPLDPPDGFTATLRPYQQRGLAWLAFLSSLGLGSCLADDM
GLGKTVQLLALETLESVQRHQDRGVGPTLLLCPMSLVGNWPQEAARFAPNLRVYAHHGGARLHGEALRDH
LERTDLVVSTYTTATRDIDELAEYEWNRVVLDEAQAVKNSLSRAAKAVRRLRAAHRVALTGTPMENRLAE
LWSIMDFLNPGLLGSSERFRTRYAIPIERHGHTEPAERLRASTRPYILRRLKTDPAIIDDLPEKIEIKQY
CQLTTEQASLYQAVVADMMEKIENTEGIERRGNVLAAMAKLKQVCNHPAQLLHDRSPVGRRSGKVIRLEE
ILEEILAEGDRVLCFTQFTEFAELLVPHLAARFGRAARDIAYLHGGTPRKRRDEMVARFQSGDGPPIFLL
SLKAGGTGLNLTAANHVVHLDRWWNPAVENQATDRAFRIGQRRTVQVRKFICTGTLEEKIDEMIEEKKAL
ADLVVTDGEGWLTELSTRDLREVFALSEGAVGE
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv2101helZ-100% (1013)PROBABLE HELICASE HELZ

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2127helZ0.099.70% (1013) helicase HelZ
M. gilvum PYR-GCK-----
M. leprae Br4923-----
M. abscessus ATCC 19977-----
M. marinum M-----
M. avium 104-----
M. smegmatis MC2 155MSMEG_1196-3e-1523.72% (506) SNF2 domain-containing protein
M. thermoresistible (build 8)TH_3552-1e-2927.92% (462) PUTATIVE putative helicase domain protein
M. ulcerans Agy99-----
M. vanbaalenii PYR-1Mvan_1096-9e-0928.87% (194) helicase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      MIEKRLTEQLLETGELTLTEKECQSLELPQHSTTVELELEGEAFTAQWTG
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      RGRVLSGDFLAERLQDYGQVNGLLRLRRVDDIYRLQLLPPGTQFTITVPP
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      PPPPRVTSSRKAKTQRRRATVDRQFHADSDYDWGQRSTPTIGFLTEAREL
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      LSEQLKAAGFDTRELVELRRQGEKLATLDDFEELLSVDVSNVDKMPHQEA
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      VARHALSRLRGRAILADEVGLGKTIEAGLAVKELTLRGLAKRVLILCPAP
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      LREQWREEMGHKFDLNFEVATRGPEIQKQDKLIMSLQLARSNIDKLTRKP
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      WDIVILDEAHRAAGSHSVKTRILITSLTTACRYAFFLTATPVQNDLLELY
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         ----MLVLHGFWSNSGGMRLWAEDSDLLVKSPSQ------ALRSARPHPF
Mb2127|M.bovis_AF2122/97            ----MLVLHGFWSNSGGMRLWAEDSDLLVKSPSQ------ALRSARPHPF
MSMEG_1196|M.smegmatis_MC2_155      ---------------------MDRADLVRRADGL------LADLG-----
TH_3552|M.thermoresistible__bu      RLVELLRPGTFTSASDFRRQFMSPYDTRTPADPAGLRRLISSVMVRTTRA
Mvan_1096|M.vanbaalenii_PYR-1       ------MLPGFAHLSPGSRVEGLAFDAVVEIVDITAAGSGAFVRYRDEFG
                                                             *                        

Rv2101|M.tuberculosis_H37Rv         AAPADLIAGIHPGKPATAVLLLPSLRSAPLDSPELIRLAPRPAARTDPML
Mb2127|M.bovis_AF2122/97            AAPADLIAGIHPGKPATAVLLLPSLRSAPLDSPELIRLAPRPAARTDPML
MSMEG_1196|M.smegmatis_MC2_155      TLRAEIAANVRAN---TDAVVERALQSTPLAG---VRPYLTLGTRISALL
TH_3552|M.thermoresistible__bu      QAGVDRVVRRAVNEAITLGSREQELYALATELLRKVMRDPSDAMRRRSLA
Mvan_1096|M.vanbaalenii_PYR-1       IEDSRLISADELKKILPVGRRGPTLAADPDQFWLAIEALRLRHAAVLNPL
                                                    .       * : .      :              

Rv2101|M.tuberculosis_H37Rv         LAWTVPVVDLDPTAALAAFDQP--------------APDVRYGAS-----
Mb2127|M.bovis_AF2122/97            LAWTVPVVDLDPTAALAAFDQP--------------APDVRYGAS-----
MSMEG_1196|M.smegmatis_MC2_155      NSEYRTVADVHTVPARLLTQVP--------------GVDIATAQA-----
TH_3552|M.thermoresistible__bu      LRLTASPFSMGTTALRMADRHPDSRVRKVLREIGHLAMDIKTSAREDRAL
Mvan_1096|M.vanbaalenii_PYR-1       LAVSSSNVEALPHQVQAVYDCM----------------------------
                                         .  .  .                                      

Rv2101|M.tuberculosis_H37Rv         ------VDYLAELAVFARELVERGRVLPQLRRDTHGAAACWRPVLQGRDV
Mb2127|M.bovis_AF2122/97            ------VDYLAELAVFARELVERGRVLPQLRRDTHGAAACWRPVLQGRDV
MSMEG_1196|M.smegmatis_MC2_155      ------VQAGAQLMADRIRTTTR----PRLDRESESDTALLADLLVLIKA
TH_3552|M.thermoresistible__bu      EITRNWLREHGRVLIFTQHTDTVTGLLRRLEAEGLTARSFHGSMSATERA
Mvan_1096|M.vanbaalenii_PYR-1       ------LTGHPKRFLLADDPGAGKTIMAGLFIKEALARGWIRRCLIVVPG
                                          :    .                 *  .     .           

Rv2101|M.tuberculosis_H37Rv         VAMTSLVSAMPPVCRAEVGGHDPHELATSALDAMVDAAVRAALSPMDLLP
Mb2127|M.bovis_AF2122/97            VAMTSLVSAMPPVCRAEVGGHDPHELATSALDAMVDAAVRAALSPMDLLP
MSMEG_1196|M.smegmatis_MC2_155      TPPAKQLRRILPRVRARVEAPN----------------------------
TH_3552|M.thermoresistible__bu      KTIAAFRSGEAPIMISTDAGAEGQDLQFCNCVLNYDLPWNPMRVEQRIGR
Mvan_1096|M.vanbaalenii_PYR-1       SLVEQWQNELREKFSLQFEVFENSLLGDSPDESLQNFPFLIARLDQFSRS
                                                         :                            

Rv2101|M.tuberculosis_H37Rv         PRRGRSKRHRAVEAWLTAL---------------TCPDGRFDAEPDELDA
Mb2127|M.bovis_AF2122/97            PRRGRSKRHRAVEAWLTAL---------------TCPDGRFDAEPDELDA
MSMEG_1196|M.smegmatis_MC2_155      ---GNGRRRRTEAAAVEE------------------PDPLLDKVADLVER
TH_3552|M.thermoresistible__bu      VDRLTQPKDEVFVANLYAQNTIDEKVFWLLAEKLRMFELLFGQVTTILGE
Mvan_1096|M.vanbaalenii_PYR-1       SELTARAVDGAYDLAIFDEAH-------------KLAVSSWGSTVTKTKR
                                              .    :                         .        

Rv2101|M.tuberculosis_H37Rv         LAEALRPWDDVGIGTVGPARATFRLSEVETENEETPAGSLWRLEFLLQST
Mb2127|M.bovis_AF2122/97            LAEALRPWDDVGIGTVGPARATFRLSEVETENEETPAGSLWRLEFLLQST
MSMEG_1196|M.smegmatis_MC2_155      IECARKPETDVWAG--------YRRDGAEIDR------------------
TH_3552|M.thermoresistible__bu      LDESKSASFESRVMEALFAENDTKMNALLDQLGMELVQAREKASELIAAD
Mvan_1096|M.vanbaalenii_PYR-1       FKLAEAIRDAVPSTLLMTATPHNGKDADYREFLTLLGSADQPVVEDPAGN
                                    :  :                     .    :                   

Rv2101|M.tuberculosis_H37Rv         QDPSLLVPAEQAWNDDGSLRRWLDRPQELLLTELGRASRIFPELVPALRT
Mb2127|M.bovis_AF2122/97            QDPSLLVPAEQAWNDDGSLRRWLDRPQELLLTELGRASRIFPELVPALRT
MSMEG_1196|M.smegmatis_MC2_155      -----------------------------LLMEFASG-------------
TH_3552|M.thermoresistible__bu      RDVSKWMAGAFEHRKGLTKAGSTELAPEVARRARMRQRRVQTWVRNVLKA
Mvan_1096|M.vanbaalenii_PYR-1       GLMRRLVKEQLVHLDGTPLFPERRASTVPYRLSPIESELYEAVSEYVREE
                                                                                      

Rv2101|M.tuberculosis_H37Rv         ACPSGLELDADGAYRFLSGTAAVLDEAGFGVLLPSWWDRRRK--------
Mb2127|M.bovis_AF2122/97            ACPSGLELDADGAYRFLSGTAAVLDEAGFGVLLPSWWDRRRK--------
MSMEG_1196|M.smegmatis_MC2_155      ------TTDVDAAQGFVG--AAVAEEA-----------------------
TH_3552|M.thermoresistible__bu      LNADIIHDTGDGEGAFITAVFSEEFEQELGGRTTMHLAFDRFGLEHHPEA
Mvan_1096|M.vanbaalenii_PYR-1       MNKVSDDDTRRSVGFALVVLQRRLASSPQAILRSLTRRRDR---------
                                               .    :        .                        

Rv2101|M.tuberculosis_H37Rv         ---------------------------------LGLVLSAYTPVDGVVGK
Mb2127|M.bovis_AF2122/97            ---------------------------------LGLVLSAYTPVDGVVGK
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      ELCAVGSPVFDELLGLLRVRGDIHATVPVIPEDIGPTPYRYSDSIRLVRR
Mvan_1096|M.vanbaalenii_PYR-1       ---------------------------------LRAQADQAHATEGKLAA
                                                                                      

Rv2101|M.tuberculosis_H37Rv         ASKFGREQLVEFRWELAVGDDPLSEEEIAALTETKSPLIRLRGQWVALDT
Mb2127|M.bovis_AF2122/97            ASKFGREQLVEFRWELAVGDDPLSEEEIAALTETKSPLIRLRGQWVALDT
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      RLVPSGSWSGQATFRATVGEAETTEHLITADINSHREHLLPRRPLEDGES
Mvan_1096|M.vanbaalenii_PYR-1       SLAATLGLGSDDPDEMSSLRAETYQDEVVSVATNARTPAELEAEILVLDR
                                                                                      

Rv2101|M.tuberculosis_H37Rv         EQMRRGLEFLERKPTGRKTTAEILALAASHPDDVDTPLEVTAVRADGWLG
Mb2127|M.bovis_AF2122/97            EQLRRGLEFLERKPTGRKTTAEILALAASHPDDVDTPLEVTAVRADGWLG
MSMEG_1196|M.smegmatis_MC2_155      -----------------------------AQIDVDRSLVRTELRGYQLFG
TH_3552|M.thermoresistible__bu      LPPAFGTAPQVIARFERAAIPQLESLRRERLDEVERQQALELERVTSGYR
Mvan_1096|M.vanbaalenii_PYR-1       LVIKAEAVYSARADAKWAALAELLTSEAMFEADRQRRKIIIFSENRDTLD
                                                                    : :        .      

Rv2101|M.tuberculosis_H37Rv         DLLAG----------------AAAASLQPLDPPDGFTATLRPYQQRGLAW
Mb2127|M.bovis_AF2122/97            DLLAG----------------AAAASLQPLDPPDGFTATLRPYQQRGLAW
MSMEG_1196|M.smegmatis_MC2_155      AQYAL----------------ARRR-------------------------
TH_3552|M.thermoresistible__bu      AQIAESSGDERARLQRALRTEEKRLTRRPDIRARAKVLAVTLDEDDWLVE
Mvan_1096|M.vanbaalenii_PYR-1       YLEDR------------------------------------------LVE
                                                                                      

Rv2101|M.tuberculosis_H37Rv         LAFLSSLGLGSCLADDMGLGKTVQLLALET--------------------
Mb2127|M.bovis_AF2122/97            LAFLSSLGLGSCLADDMGLGKTVQLLALET--------------------
MSMEG_1196|M.smegmatis_MC2_155      ----------VLLCDELGLGKTLQALTVAA--------------------
TH_3552|M.thermoresistible__bu      ETWAGPSGDETTLTYEWGVERPIIESAVTGGPIGVLALCSDMHWVDESEV
Mvan_1096|M.vanbaalenii_PYR-1       LLGRTVDVQVIHGAMSWTDRRRAQANFIAE--------------------
                                                   .    :      :                      

Rv2101|M.tuberculosis_H37Rv         --LESVQRHQDRGVGPTLLLCPMSLVGNWPQEAARFAPNLRVYAHHGGAR
Mb2127|M.bovis_AF2122/97            --LESVQRHQDRGVGPTLLLCPMSLVGNWQQEAARFAPNLRVYAHHGGAR
MSMEG_1196|M.smegmatis_MC2_155      --HLAAAETMR----HTLVICPANTGIHWAEETLKHT---WLTPLEIRGR
TH_3552|M.thermoresistible__bu      TRCGSCERSLCDACGEDAVFAACAVCAQWCCGRCRRETGGLCRTCASPQR
Mvan_1096|M.vanbaalenii_PYR-1       --PSSSVLIATDAAGEGVNLQVAHLMVNYDVPWNPNRLEQRFGRIHRIGQ
                                        :              :       ::                    :

Rv2101|M.tuberculosis_H37Rv         L---HGEALRDHLERTDLVVSTYTTATRDIDELAEYEWNRVVLDEAQAVK
Mb2127|M.bovis_AF2122/97            L---HGEALRDHLERTDLVVSTYTTATRDIDELSEYEWNRVVLDEAQAVK
MSMEG_1196|M.smegmatis_MC2_155      R---REERLAEWKDKGGLAIVTFSALSKITLPERP---GLVIVDEAHLLR
TH_3552|M.thermoresistible__bu      VPELDDEFFVAWRLGGGNIVRVGERVAELVRPDGSPPAVLVSAQDYDDPR
Mvan_1096|M.vanbaalenii_PYR-1       RHTCHLWNLVAADTREGDVFRTLLEKVEVQREALGDQVFDVLGEVLTEIS
                                            :       .  . .     .            *  :      

Rv2101|M.tuberculosis_H37Rv         NS----------------LSRAAKAVRRLRAAHR--VALTGTPMENRLAE
Mb2127|M.bovis_AF2122/97            NS----------------LSRAAKAVRRLRAAHR--VALTGTPMENRLAE
MSMEG_1196|M.smegmatis_MC2_155      DP----------------KSDRARAVRNVLTADACVLFLSGVPLHNRIEG
TH_3552|M.thermoresistible__bu      MARLRAYAHQNGLPLDCGLVKRDLTVRDETPVSTRLRLHTSRTVAVELSI
Mvan_1096|M.vanbaalenii_PYR-1       LS---------------QLLRRAVGGEAPRGEIASQLDSVSGRLESAVEK
                                     .                        .             .  :   :  

Rv2101|M.tuberculosis_H37Rv         LWSIMDFLNPGLLGSSERFRTRYAIPIERHGHTEPAERLRASTR------
Mb2127|M.bovis_AF2122/97            LWSIMDFLNPGLLGSSERFRTRYAIPIERHGHTEPAERLRASTR------
MSMEG_1196|M.smegmatis_MC2_155      FRHLADFLQPDVATKVP----------PNAGAQGSVAFRRTADR------
TH_3552|M.thermoresistible__bu      DSSLDAALDLDVVEAVPAAPEVPVSREEDFGLSVALTQMRREAPPPRRPA
Mvan_1096|M.vanbaalenii_PYR-1       RAASVSTLTPEELAVLR----------REMEIAKAMSFQPDVAR------
                                           *                          .               

Rv2101|M.tuberculosis_H37Rv         -----------PYILRRLKTDPAIIDDLPEKIEIK-------QYCQLTTE
Mb2127|M.bovis_AF2122/97            -----------PYILRRLKTDPAIIDDLPEKIEIK-------QYCQLTTE
MSMEG_1196|M.smegmatis_MC2_155      -----------VYLRRDYR---DVVAELPQRISTD-------EWVRLTGE
TH_3552|M.thermoresistible__bu      VVVTHRAQFVDLYLETDRLVREELVVTNDKALTLTGTSSTDLQWVEPSVD
Mvan_1096|M.vanbaalenii_PYR-1       -----------DFMVRAASLFHVDITMRGDAWQVG--------YVPTRLR
                                                ::          :    .             :      

Rv2101|M.tuberculosis_H37Rv         QASLYQAVVADMMEKIENTEGIERRGNVLAAMAKLKQVCNHPAQ------
Mb2127|M.bovis_AF2122/97            QASLYQAVVADMMEKIENTEGIERRGNVLAAMAKLKQVCNHPAQ------
MSMEG_1196|M.smegmatis_MC2_155      DRVRYRRAVD---------------GGNFSAIRQAAWPSGMPGP------
TH_3552|M.thermoresistible__bu      HPLVAEGRLDDLHVSVERRNEALVVDARLGSASVGRWVACPDGTSIAEQV
Mvan_1096|M.vanbaalenii_PYR-1       DQFGSSLMARYDRVAFEHSDDQVFAADPPELMAPGHPLVSALAD------
                                    .                                         .       

Rv2101|M.tuberculosis_H37Rv         -----LLHDRSPVGRRSGKVIRLEEILEEILAEGDRVLCFTQFTEFAELL
Mb2127|M.bovis_AF2122/97            -----LLHDRSPVGRRSGKVIRLEEILEEILAEGDRVLCFTQFTEFAELL
MSMEG_1196|M.smegmatis_MC2_155      -----PGP--------SAKLDRLIELISEAHINGARVVVLSHFPGVLETI
TH_3552|M.thermoresistible__bu      SCYEHLQTLGTPGGRLGKQTYSIEEIVTSFPAPSECTAADRTIRVVAGTV
Mvan_1096|M.vanbaalenii_PYR-1       ----------------AAGEEFGSSLNHGIVLSDNRSSDDYVLVTVVATA
                                                    .       .:       .        :  .    

Rv2101|M.tuberculosis_H37Rv         VP-----------HLAARFGRAARDIAYLHGGTPRKRRDEMVARFQ----
Mb2127|M.bovis_AF2122/97            VP-----------HLAARFGRAARDIAYLHGGTPRKRRDEMVARFQ----
MSMEG_1196|M.smegmatis_MC2_155      RK-----------ALPG------TVFGPLDESVPD--RQAMLDAFA----
TH_3552|M.thermoresistible__bu      PTTKDTDVVPADTESLAALGISPANRAPSAEPVPRDLAKDLLDRAARSYT
Mvan_1096|M.vanbaalenii_PYR-1       EG------------NPSTVTTYAVTVGGDRQQVSPGLYTDLEMGAT----
                                                    .         .     ..      :         

Rv2101|M.tuberculosis_H37Rv         ------------------------SGDGPPIFLLSLKAGGTGLN------
Mb2127|M.bovis_AF2122/97            ------------------------SGDGPPIFLLSLKAGGTGLN------
MSMEG_1196|M.smegmatis_MC2_155      ------------------------TARGPATLLAQLDVGPLDLRR-----
TH_3552|M.thermoresistible__bu      AAIRNGLEVTETWRGHGTATHVYRTFDGQPLSPNLDDIGARHSDFGVCRD
Mvan_1096|M.vanbaalenii_PYR-1       -------------------------PEPREVAAAEAAVAAFSDDPD----
                                                                          .           

Rv2101|M.tuberculosis_H37Rv         -----------------------LTAANHVVHLDRWWNPAVENQATDRAF
Mb2127|M.bovis_AF2122/97            -----------------------LTAANHVVHLDRWWNPAVENQATDRAF
MSMEG_1196|M.smegmatis_MC2_155      -----------------------LSMPLVAIVTEPQWQPRAERRMIGRTQ
TH_3552|M.thermoresistible__bu      GHFYAAGTAALCEACHTWACRACDMLEHRASVECPGCAHAVCRRCVASVH
Mvan_1096|M.vanbaalenii_PYR-1       -----------------------RDIAAVAYVRGTASPETADGWRAARGQ
                                                                 .          .         

Rv2101|M.tuberculosis_H37Rv         RIGQRRTVQVRKFICTGTLEEK-----------------IDEMIEEKKAL
Mb2127|M.bovis_AF2122/97            RIGQRRTVQVRKFICTGTLEEK-----------------IDEMIEEKKAL
MSMEG_1196|M.smegmatis_MC2_155      RLSDLHTVRVHRLLARGSIDEP-----------------IRRLAHHPDEP
TH_3552|M.thermoresistible__bu      SVPKTRCLLCGDRACPDCGRDPDVAACVMCDRAMCGSCRIGDTCPACSRL
Mvan_1096|M.vanbaalenii_PYR-1       LRDELTARGLDPVAALPGQGWDFTTG--------------ADVIMFWSAA
                                       .          .                                .  

Rv2101|M.tuberculosis_H37Rv         ADLVVTDGEGWLTELSTRDLREVFALSEGAVGE-----------------
Mb2127|M.bovis_AF2122/97            ADLVVTDGEGWLTELSTRDLREVFALSEGAVGE-----------------
MSMEG_1196|M.smegmatis_MC2_155      PPHQDEMVRAEQTRLARLDRMR----------------------------
TH_3552|M.thermoresistible__bu      APATDDERRSLPDALAVEGASLLIASDEDATVVLIDRGSAREQAIIRDGS
Mvan_1096|M.vanbaalenii_PYR-1       PPGEMERRRAEKHVAANVGGKYRVALG-----------------------
                                    .       ..     :  .                               

Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      VNRWVAFDRTQIDSAYRLRLAASRALKFPVVPRVELLKPEVPHPGPRILL
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      RSDRRFYPAWSAATLAGRDPEGRPTPDDDLAAAVADQFPPLSSCPEPVIK
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      APARLRPLLASLNPPPTTPMVIRWERVGSDVAVVPSGISVATIDGPNQHE
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      AITEWREPDRPTEWISQSWNPVPAVRMTAADGEVEAALVSMGALVALGVH
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      ISGRTDWYVVAASAHAPAATLLSRSMGLADADEVGTFTDPSRIRLSTIAN
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      ASSVSHDVTPRGELKPASARADHETAAALAAWCPDATVMTPPLLVMPDEL
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      RIALRKVITPAQRYTLDIGASVVETVSTQDGQEWKYEVALAPGSTDARRL
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      DHITRQTLDWGGIDREGHFGTAHVMCGYCNQICCSACTDGMVACDCCGAP
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         --------------------------------------------------
Mb2127|M.bovis_AF2122/97            --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      --------------------------------------------------
TH_3552|M.thermoresistible__bu      ICKRCVREPSAGTYLCHACASMRPPTRQEARNHGRLLFTRGMLIGIDPLH
Mvan_1096|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Rv2101|M.tuberculosis_H37Rv         ----------------------------------------------
Mb2127|M.bovis_AF2122/97            ----------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155      ----------------------------------------------
TH_3552|M.thermoresistible__bu      TVVVERAKPRWELHVGNGEKQAIANPSVLRHLDQRLAGADDQEQGG
Mvan_1096|M.vanbaalenii_PYR-1       ----------------------------------------------