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DRADLVRRADGLLADLGTLRAEIAANVRANTDAVVERALQSTPLAGVRPYLTLGTRISALLNSEYRTVAD VHTVPARLLTQVPGVDIATAQAVQAGAQLMADRIRTTTRPRLDRESESDTALLADLLVLIKATPPAKQLR RILPRVRARVEAPNGNGRRRRTEAAAVEEPDPLLDKVADLVERIECARKPETDVWAGYRRDGAEIDRLLM EFASGTTDVDAAQGFVGAAVAEEAAQIDVDRSLVRTELRGYQLFGAQYALARRRVLLCDELGLGKTLQAL TVAAHLAAAETMRHTLVICPANTGIHWAEETLKHTWLTPLEIRGRRREERLAEWKDKGGLAIVTFSALSK ITLPERPGLVIVDEAHLLRDPKSDRARAVRNVLTADACVLFLSGVPLHNRIEGFRHLADFLQPDVATKVP PNAGAQGSVAFRRTADRVYLRRDYRDVVAELPQRISTDEWVRLTGEDRVRYRRAVDGGNFSAIRQAAWPS GMPGPPGPSAKLDRLIELISEAHINGARVVVLSHFPGVLETIRKALPGTVFGPLDESVPDRQAMLDAFAT ARGPATLLAQLDVGPLDLRRLSMPLVAIVTEPQWQPRAERRMIGRTQRLSDLHTVRVHRLLARGSIDEPI RRLAHHPDEPPPHQDEMVRAEQTRLARLDRMR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1196 | - | - | 100% (663) | SNF2 domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2127 | helZ | 1e-15 | 23.72% (506) | helicase HelZ |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv2101 | helZ | 1e-15 | 23.72% (506) | helicase HelZ |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_3552 | - | 3e-10 | 28.74% (254) | PUTATIVE putative helicase domain protein |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2127|M.bovis_AF2122/97 --------------------------------------------------
Rv2101|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu MIEKRLTEQLLETGELTLTEKECQSLELPQHSTTVELELEGEAFTAQWTG
Mb2127|M.bovis_AF2122/97 --------------------------------------------------
Rv2101|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu RGRVLSGDFLAERLQDYGQVNGLLRLRRVDDIYRLQLLPPGTQFTITVPP
Mb2127|M.bovis_AF2122/97 --------------------------------------------------
Rv2101|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu PPPPRVTSSRKAKTQRRRATVDRQFHADSDYDWGQRSTPTIGFLTEAREL
Mb2127|M.bovis_AF2122/97 --------------------------------------------------
Rv2101|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu LSEQLKAAGFDTRELVELRRQGEKLATLDDFEELLSVDVSNVDKMPHQEA
Mb2127|M.bovis_AF2122/97 --------------------------------------------------
Rv2101|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu VARHALSRLRGRAILADEVGLGKTIEAGLAVKELTLRGLAKRVLILCPAP
Mb2127|M.bovis_AF2122/97 --------------------------------------------------
Rv2101|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu LREQWREEMGHKFDLNFEVATRGPEIQKQDKLIMSLQLARSNIDKLTRKP
Mb2127|M.bovis_AF2122/97 --------------------------------------------------
Rv2101|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu WDIVILDEAHRAAGSHSVKTRILITSLTTACRYAFFLTATPVQNDLLELY
Mb2127|M.bovis_AF2122/97 --------------------------------------------------
Rv2101|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu RLVELLRPGTFTSASDFRRQFMSPYDTRTPADPAGLRRLISSVMVRTTRA
Mb2127|M.bovis_AF2122/97 --------------------------------------------------
Rv2101|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu QAGVDRVVRRAVNEAITLGSREQELYALATELLRKVMRDPSDAMRRRSLA
Mb2127|M.bovis_AF2122/97 -------------------------------------------------M
Rv2101|M.tuberculosis_H37Rv -------------------------------------------------M
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu LRLTASPFSMGTTALRMADRHPDSRVRKVLREIGHLAMDIKTSAREDRAL
Mb2127|M.bovis_AF2122/97 LVLHGFWSNSGGMRLWAEDSD----LLVKSPSQALRSARPHPFAAPADLI
Rv2101|M.tuberculosis_H37Rv LVLHGFWSNSGGMRLWAEDSD----LLVKSPSQALRSARPHPFAAPADLI
MSMEG_1196|M.smegmatis_MC2_155 ----------------MDRAD----LVRRADGLLADLG-----TLRAEIA
TH_3552|M.thermoresistible__bu EITRNWLREHGRVLIFTQHTDTVTGLLRRLEAEGLTARSFHGSMSATERA
: :* *: : . ::
Mb2127|M.bovis_AF2122/97 AGIHPGKPATAVLLLP-------------------SLRSAPLDSPELIRL
Rv2101|M.tuberculosis_H37Rv AGIHPGKPATAVLLLP-------------------SLRSAPLDSPELIRL
MSMEG_1196|M.smegmatis_MC2_155 ANVRAN---TDAVVER-------------------ALQSTPLAG---VRP
TH_3552|M.thermoresistible__bu KTIAAFRSGEAPIMISTDAGAEGQDLQFCNCVLNYDLPWNPMRVEQRIGR
: . :: * *: :
Mb2127|M.bovis_AF2122/97 APRPAARTDPMLLA-----------------------------WTVPVVD
Rv2101|M.tuberculosis_H37Rv APRPAARTDPMLLA-----------------------------WTVPVVD
MSMEG_1196|M.smegmatis_MC2_155 YLTLGTRISALLNS-----------------------------EYRTVAD
TH_3552|M.thermoresistible__bu VDRLTQPKDEVFVANLYAQNTIDEKVFWLLAEKLRMFELLFGQVTTILGE
. :: : : :
Mb2127|M.bovis_AF2122/97 LDPTAALAAFDQPAPDVRYGASVDYLAELAVFARELVERGRVLPQLRRDT
Rv2101|M.tuberculosis_H37Rv LDPTAALAAFDQPAPDVRYGASVDYLAELAVFARELVERGRVLPQLRRDT
MSMEG_1196|M.smegmatis_MC2_155 VHTVPARLLTQVPGVDIATAQAVQAGAQLMADRIRTTTR----PRLDRES
TH_3552|M.thermoresistible__bu LDESKSASFESRVMEALFAENDTKMNALLDQLGMELVQAREKASELIAAD
:. : . : .. * * . . ..*
Mb2127|M.bovis_AF2122/97 HGAAACWRPVLQGRDVVAMTSLVSAMPPVCR-AEVGGHDPHELATSALDA
Rv2101|M.tuberculosis_H37Rv HGAAACWRPVLQGRDVVAMTSLVSAMPPVCR-AEVGGHDPHELATSALDA
MSMEG_1196|M.smegmatis_MC2_155 ESDTALLADLLVLIKATPPAKQLRRILPRVR-ARVEAPN-----------
TH_3552|M.thermoresistible__bu RDVSKWMAGAFEHRKGLTKAGSTELAPEVARRARMRQRRVQTWVRNVLKA
.. : : . . : * *.:
Mb2127|M.bovis_AF2122/97 M----------VDAAVRAALSPMDLLPPRRGRSKRHRAVEAWLTALTCPD
Rv2101|M.tuberculosis_H37Rv M----------VDAAVRAALSPMDLLPPRRGRSKRHRAVEAWLTALTCPD
MSMEG_1196|M.smegmatis_MC2_155 ------------------------------GNGRRRRTEAAAVEE---PD
TH_3552|M.thermoresistible__bu LNADIIHDTGDGEGAFITAVFSEEFEQELGGRTTMHLAFDRFGLEHHPEA
*. : :
Mb2127|M.bovis_AF2122/97 GRFDAEPDELDALAEALRPWDDVGIGT------VGPARATFRLSEVETEN
Rv2101|M.tuberculosis_H37Rv GRFDAEPDELDALAEALRPWDDVGIGT------VGPARATFRLSEVETEN
MSMEG_1196|M.smegmatis_MC2_155 PLLDKVADLVERIECARKPETDVWAG--------------YRRDGAEIDR
TH_3552|M.thermoresistible__bu ELCAVGSPVFDELLGLLRVRGDIHATVPVIPEDIGPTPYRYSDSIRLVRR
. .: : : *: : . .
Mb2127|M.bovis_AF2122/97 EETPAGSLW---RLEFLLQSTQDPSLLVPAEQAWNDDGSLRRWLDRPQEL
Rv2101|M.tuberculosis_H37Rv EETPAGSLW---RLEFLLQSTQDPSLLVPAEQAWNDDGSLRRWLDRPQEL
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu RLVPSGSWSGQATFRATVGEAETTEHLITADINSHREHLLPRRPLEDGES
Mb2127|M.bovis_AF2122/97 LLTELGRASRIFPELVPALRTACPSGLELDADGAYR---------FLSGT
Rv2101|M.tuberculosis_H37Rv LLTELGRASRIFPELVPALRTACPSGLELDADGAYR---------FLSGT
MSMEG_1196|M.smegmatis_MC2_155 LLMEFASG-------------------TTDVDAAQG---------FVG--
TH_3552|M.thermoresistible__bu LPPAFGTAPQVIARFERAAIPQLESLRRERLDEVERQQALELERVTSGYR
* :. . * . .
Mb2127|M.bovis_AF2122/97 AAVLDEAGFGVLLPSWWDRRRKLGLVLSAYTPVDGVVGKASKFGREQLVE
Rv2101|M.tuberculosis_H37Rv AAVLDEAGFGVLLPSWWDRRRKLGLVLSAYTPVDGVVGKASKFGREQLVE
MSMEG_1196|M.smegmatis_MC2_155 AAVAEEA-------------------------------------------
TH_3552|M.thermoresistible__bu AQIAESSGDERARLQRALRTEEKRLTRRPDIRARAKVLAVTLDEDDWLVE
* : :.:
Mb2127|M.bovis_AF2122/97 FRWELAVGDDPLSEEEIAALTETKSPLIR---------------------
Rv2101|M.tuberculosis_H37Rv FRWELAVGDDPLSEEEIAALTETKSPLIR---------------------
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu ETWAGPSGDETTLTYEWGVERPIIESAVTGGPIGVLALCSDMHWVDESEV
Mb2127|M.bovis_AF2122/97 ------LRGQWVALDTEQLRRGLEFLERKPTGRKTTAEILALAASHPDDV
Rv2101|M.tuberculosis_H37Rv ------LRGQWVALDTEQMRRGLEFLERKPTGRKTTAEILALAASHPDDV
MSMEG_1196|M.smegmatis_MC2_155 ---------------------------------------------AQIDV
TH_3552|M.thermoresistible__bu TRCGSCERSLCDACGEDAVFAACAVCAQWCCGRCRRETGGLCRTCASPQR
:
Mb2127|M.bovis_AF2122/97 DTPLEVTAVRADGWLGDLLAGAAAASLQPLDPPDGFTATLRPYQQRGLAW
Rv2101|M.tuberculosis_H37Rv DTPLEVTAVRADGWLGDLLAGAAAASLQPLDPPDGFTATLRPYQQRGLAW
MSMEG_1196|M.smegmatis_MC2_155 DRSLVRTELRGYQLFGAQYALARRR-------------------------
TH_3552|M.thermoresistible__bu VPELDDEFFVAWRLGGGNIVRVGERVAELVRPDGSPPAVLVSAQDYDDPR
* . . * . .
Mb2127|M.bovis_AF2122/97 LAFLSSLGLGSCLADDMGLGK------------TVQLLALETLESVQRHQ
Rv2101|M.tuberculosis_H37Rv LAFLSSLGLGSCLADDMGLGK------------TVQLLALETLESVQRHQ
MSMEG_1196|M.smegmatis_MC2_155 ----------VLLCDELGLGK------------TLQALTVAAHLAAAETM
TH_3552|M.thermoresistible__bu MARLRAYAHQNGLPLDCGLVKRDLTVRDETPVSTRLRLHTSRTVAVELSI
* : ** * * * :.
Mb2127|M.bovis_AF2122/97 DRGVGPTLLLCPMSLVGNWQQEAARFAPNLRVYAHHGGARLHGEALR---
Rv2101|M.tuberculosis_H37Rv DRGVGPTLLLCPMSLVGNWPQEAARFAPNLRVYAHHGGARLHGEALR---
MSMEG_1196|M.smegmatis_MC2_155 R----HTLVICPANTGIHWAEETLKHT---WLTPLEIRGRRREERLA---
TH_3552|M.thermoresistible__bu DSSLDAALDLDVVEAVPAAPEVPVSREEDFGLSVALTQMRREAPPPRRPA
:* : . : . : * .
Mb2127|M.bovis_AF2122/97 ----------------DHLERTDLVVSTYTTATRDIDELSEYEWNRVVLD
Rv2101|M.tuberculosis_H37Rv ----------------DHLERTDLVVSTYTTATRDIDELAEYEWNRVVLD
MSMEG_1196|M.smegmatis_MC2_155 ----------------EWKDKGGLAIVTFSALSKITLPERP---GLVIVD
TH_3552|M.thermoresistible__bu VVVTHRAQFVDLYLETDRLVREELVVTNDKALTLTGTSSTDLQWVEPSVD
: : *.: . .: : :*
Mb2127|M.bovis_AF2122/97 EAQAVKNSLSRAAKAVRR------------LRAAHR--VALTGTPMENRL
Rv2101|M.tuberculosis_H37Rv EAQAVKNSLSRAAKAVRR------------LRAAHR--VALTGTPMENRL
MSMEG_1196|M.smegmatis_MC2_155 EAHLLRDPKSDRARAVRN------------VLTADACVLFLSGVPLHNRI
TH_3552|M.thermoresistible__bu HPLVAEGRLDDLHVSVERRNEALVVDARLGSASVGRWVACPDGTSIAEQV
.. .. . :*.. :. *..: :::
Mb2127|M.bovis_AF2122/97 AELWSIMDFLNPG-------------------------------------
Rv2101|M.tuberculosis_H37Rv AELWSIMDFLNPG-------------------------------------
MSMEG_1196|M.smegmatis_MC2_155 EGFRHLADFLQPD-------------------------------------
TH_3552|M.thermoresistible__bu SCYEHLQTLGTPGGRLGKQTYSIEEIVTSFPAPSECTAADRTIRVVAGTV
: : *.
Mb2127|M.bovis_AF2122/97 -----------------LLGSSERFRTRYAIPIERHGHTEPAERLR----
Rv2101|M.tuberculosis_H37Rv -----------------LLGSSERFRTRYAIPIERHGHTEPAERLR----
MSMEG_1196|M.smegmatis_MC2_155 -----------------VATKVP----------PNAGAQGSVAFRR----
TH_3552|M.thermoresistible__bu PTTKDTDVVPADTESLAALGISPANRAPSAEPVPRDLAKDLLDRAARSYT
.
Mb2127|M.bovis_AF2122/97 -----------------ASTRPYILRRLKTDPAIIDDLPEK---------
Rv2101|M.tuberculosis_H37Rv -----------------ASTRPYILRRLKTDPAIIDDLPEK---------
MSMEG_1196|M.smegmatis_MC2_155 -----------------TADRVYLRRDYR---DVVAELPQR---------
TH_3552|M.thermoresistible__bu AAIRNGLEVTETWRGHGTATHVYRTFDGQPLSPNLDDIGARHSDFGVCRD
:: : * : : :: :
Mb2127|M.bovis_AF2122/97 -------------------------IEIKQYCQLTTEQASLYQAVVADMM
Rv2101|M.tuberculosis_H37Rv -------------------------IEIKQYCQLTTEQASLYQAVVADMM
MSMEG_1196|M.smegmatis_MC2_155 -------------------------ISTDEWVRLTGEDRVRYRRAVD---
TH_3552|M.thermoresistible__bu GHFYAAGTAALCEACHTWACRACDMLEHRASVECPGCAHAVCRRCVASVH
:. . . : *
Mb2127|M.bovis_AF2122/97 EKIEN----------------------------TEGIERRGNVLAAMAKL
Rv2101|M.tuberculosis_H37Rv EKIEN----------------------------TEGIERRGNVLAAMAKL
MSMEG_1196|M.smegmatis_MC2_155 ----------------------------------------GGNFSAIRQA
TH_3552|M.thermoresistible__bu SVPKTRCLLCGDRACPDCGRDPDVAACVMCDRAMCGSCRIGDTCPACSRL
*. .* :
Mb2127|M.bovis_AF2122/97 KQVCNHPAQLLHDRSPVG--------------------------------
Rv2101|M.tuberculosis_H37Rv KQVCNHPAQLLHDRSPVG--------------------------------
MSMEG_1196|M.smegmatis_MC2_155 AWPSGMPGPPGP--------------------------------------
TH_3552|M.thermoresistible__bu APATDDERRSLPDALAVEGASLLIASDEDATVVLIDRGSAREQAIIRDGS
.
Mb2127|M.bovis_AF2122/97 -------------------------RRSGKVIRLEEILEEILAEGDRVLC
Rv2101|M.tuberculosis_H37Rv -------------------------RRSGKVIRLEEILEEILAEGDRVLC
MSMEG_1196|M.smegmatis_MC2_155 ---------------------------SAKLDRLIELISEAHINGARVVV
TH_3552|M.thermoresistible__bu VNRWVAFDRTQIDSAYRLRLAASRALKFPVVPRVELLKPEVPHPGPRILL
: *: : * * *::
Mb2127|M.bovis_AF2122/97 FTQFTEFAELLVPHLAAR------------FGRAARDIAYLHGG-----T
Rv2101|M.tuberculosis_H37Rv FTQFTEFAELLVPHLAAR------------FGRAARDIAYLHGG-----T
MSMEG_1196|M.smegmatis_MC2_155 LSHFPGVLETIRKALPG------------------TVFGPLDES-----V
TH_3552|M.thermoresistible__bu RSDRRFYPAWSAATLAGRDPEGRPTPDDDLAAAVADQFPPLSSCPEPVIK
:. *.. : *
Mb2127|M.bovis_AF2122/97 PRKRRDEMVARFQSGDGPPIFLLSLKAG--------GTGLN-LTAANHVV
Rv2101|M.tuberculosis_H37Rv PRKRRDEMVARFQSGDGPPIFLLSLKAG--------GTGLN-LTAANHVV
MSMEG_1196|M.smegmatis_MC2_155 PD--RQAMLDAFATARGPATLLAQLDVG--------PLDLRRLSMPLVAI
TH_3552|M.thermoresistible__bu APARLRPLLASLNPPPTTPMVIRWERVGSDVAVVPSGISVATIDGPNQHE
. :: : . .. .: .* .: : .
Mb2127|M.bovis_AF2122/97 HLDRWWNPAVENQATDRAFR--------------------------IGQR
Rv2101|M.tuberculosis_H37Rv HLDRWWNPAVENQATDRAFR--------------------------IGQR
MSMEG_1196|M.smegmatis_MC2_155 VTEPQWQPRAERRMIGRTQR--------------------------LSDL
TH_3552|M.thermoresistible__bu AITEWREPDRPTEWISQSWNPVPAVRMTAADGEVEAALVSMGALVALGVH
:* . .:: . :.
Mb2127|M.bovis_AF2122/97 RTVQVRKFICTGTLEEKIDEMIEEKKALADLVVTDGEGWLTELSTRDLRE
Rv2101|M.tuberculosis_H37Rv RTVQVRKFICTGTLEEKIDEMIEEKKALADLVVTDGEGWLTELSTRDLRE
MSMEG_1196|M.smegmatis_MC2_155 HTVRVHRLLARGSIDEPIRRLAHHPDEPPPHQDEMVRAEQTRLARLDRMR
TH_3552|M.thermoresistible__bu ISGRTDWYVVAASAHAPAATLLSRSMGLADADEVGTFTDPSRIRLSTIAN
: :. : .: . : . . :.: .
Mb2127|M.bovis_AF2122/97 VFALSEGAVGE---------------------------------------
Rv2101|M.tuberculosis_H37Rv VFALSEGAVGE---------------------------------------
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu ASSVSHDVTPRGELKPASARADHETAAALAAWCPDATVMTPPLLVMPDEL
Mb2127|M.bovis_AF2122/97 --------------------------------------------------
Rv2101|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu RIALRKVITPAQRYTLDIGASVVETVSTQDGQEWKYEVALAPGSTDARRL
Mb2127|M.bovis_AF2122/97 --------------------------------------------------
Rv2101|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu DHITRQTLDWGGIDREGHFGTAHVMCGYCNQICCSACTDGMVACDCCGAP
Mb2127|M.bovis_AF2122/97 --------------------------------------------------
Rv2101|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3552|M.thermoresistible__bu ICKRCVREPSAGTYLCHACASMRPPTRQEARNHGRLLFTRGMLIGIDPLH
Mb2127|M.bovis_AF2122/97 ----------------------------------------------
Rv2101|M.tuberculosis_H37Rv ----------------------------------------------
MSMEG_1196|M.smegmatis_MC2_155 ----------------------------------------------
TH_3552|M.thermoresistible__bu TVVVERAKPRWELHVGNGEKQAIANPSVLRHLDQRLAGADDQEQGG