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RALIIVDVQNDFCEGGSLAVTGGAALARAISDYLAEAADYHHVVATKDFHIDPGDHFSGTPDYSSSWPPH CVSGTPGADFHPSLDTSAIEAVFYKGAYTGAYSGFEGVDENGTPLLNWLRQRGVDEVDVVGIATDHCVRQ TAEDAVRNGLATRVLVDLTAGVSADTTVAALEEMRTASVELVCSS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2043c | pncA | - | 100% (186) | PYRAZINAMIDASE/NICOTINAMIDAS PNCA (PZase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2069c | pncA | 1e-105 | 99.46% (186) | pyrazinamidase/nicotinamidas PNCA (PZase) |
| M. gilvum PYR-GCK | Mflv_1089 | - | 4e-69 | 66.84% (187) | isochorismatase hydrolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1472c | - | 5e-61 | 59.34% (182) | putative nicotinamidase/pyrazinamidase |
| M. marinum M | MMAR_3016 | pncA | 3e-70 | 69.19% (185) | pyrazinamidase/nicotinamidase, PncA |
| M. avium 104 | MAV_2472 | - | 2e-75 | 71.58% (183) | isochorismatase family protein |
| M. smegmatis MC2 155 | MSMEG_6506 | - | 8e-69 | 66.48% (182) | nicotinamidase/pyrazinamidase |
| M. thermoresistible (build 8) | TH_1796 | pncA | 8e-71 | 69.19% (185) | PYRAZINAMIDASE/NICOTINAMIDAS PNCA (PZase) |
| M. ulcerans Agy99 | MUL_2257 | pncA | 5e-68 | 67.03% (185) | pyrazinamidase/nicotinamidase, PncA |
| M. vanbaalenii PYR-1 | Mvan_5728 | - | 5e-68 | 67.58% (182) | isochorismatase hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1089|M.gilvum_PYR-GCK MSTPATTRALVIVDVQNDFCEGGSLAVDGGAAVARGISTLLGSLGIDGSH
Mvan_5728|M.vanbaalenii_PYR-1 MTS---NRTLIIVDVQNDFCEGGSLAVAGGAAVARGISDLLAS-----AP
MSMEG_6506|M.smegmatis_MC2_155 ------MRALIVVDVQNDFCEGGSLAVTGGAAVARGITELLAG-----DH
Rv2043c|M.tuberculosis_H37Rv ------MRALIIVDVQNDFCEGGSLAVTGGAALARAISDYLAE-----AA
Mb2069c|M.bovis_AF2122/97 ------MRALIIVDVQNDFCEGGSLAVTGGAALARAISDYLAE-----AA
MMAR_3016|M.marinum_M ------MRALIIVDLQNDFCAGGALPVHNADLVARAINDYLAG-----SP
MUL_2257|M.ulcerans_Agy99 ------MRALVIVDLQNDFCAGGALPGQNADLVARAINDYLAG-----SP
MAV_2472|M.avium_104 ------MRALIIVDVQNDFCEGGSVPVAGGAAVAPAINAYLDD-----AP
TH_1796|M.thermoresistible__bu ------MTALIIVDVQNDFCEGGALAVAGGATTARRISDLLRS-----ET
MAB_1472c|M.abscessus_ATCC_199 -----MGRALIVVDVQNDFCEGGSLSVPGGAALARTLNHLTRS------G
:*::**:***** **::. .. * :.
Mflv_1089|M.gilvum_PYR-GCK SYHHVVATKDFHIDPGAHFSDQPDYVDSWPVHCVAGSEGAEFHPDLDTAA
Mvan_5728|M.vanbaalenii_PYR-1 DYRHVVATKDFHIDPGPHFSDHPDYVDSWPVHCVAHTAGAEFHPDLDTTA
MSMEG_6506|M.smegmatis_MC2_155 GYDHVVATMDFHIDPGEHFSDTPDYQVSWPRHCVADTPGAEFHPEFDAGA
Rv2043c|M.tuberculosis_H37Rv DYHHVVATKDFHIDPGDHFSGTPDYSSSWPPHCVSGTPGADFHPSLDTSA
Mb2069c|M.bovis_AF2122/97 DYHHVVATKDFHIDPGDDFSGTPDYSSSWPPHCVSGTPGADFHPSLDTSA
MMAR_3016|M.marinum_M GYDRVVATQDFHIDPGAHFSDSPDYSSSWPPHCRAGSTGAQFCPDLDVAP
MUL_2257|M.ulcerans_Agy99 GYDRVVAAQDFHIDPGAHFSDCPDYSSSWPPHCRAGSTGAQFCPDLDVAP
MAV_2472|M.avium_104 GYDYVVATQDFHIDPGDHFSDRPDYSSSWPAHCLAGSAGADFRPELDTTR
TH_1796|M.thermoresistible__bu GYTHVVATKDQHIDPGDHFSDHPDFVRSWPRHCVAGTPGAEFHPDLDTGR
MAB_1472c|M.abscessus_ATCC_199 AYDAVVATRDFHVDPGGHFSENPDFQTSWPPHCRAGTPGADFHPYLDMGP
* ***: * *:*** .** **: *** ** : : **:* * :*
Mflv_1089|M.gilvum_PYR-GCK VEAVFYKGHYSAAYSGFEGTDDDGTSLADWLRERNVAAVDVVGIATDHCV
Mvan_5728|M.vanbaalenii_PYR-1 VEAVFKKGHHSAAYSGFEGKDDNGSALADWLRAHDVDAVDVVGIATDYCV
MSMEG_6506|M.smegmatis_MC2_155 VEVVFRKGHYSAAYSGFEGTDESGTTLADWLRERDVDAVDVVGIATDYCV
Rv2043c|M.tuberculosis_H37Rv IEAVFYKGAYTGAYSGFEGVDENGTPLLNWLRQRGVDEVDVVGIATDHCV
Mb2069c|M.bovis_AF2122/97 IEAVFYKGAYTGAYSGFEGVDENGTPLLNWLRQRGVDEVDVVGIATDHCV
MMAR_3016|M.marinum_M IEAVFRKGAYCAAYSGFEGVDRHGTTLEDWLRQRSIDAVDVVGVATDHCV
MUL_2257|M.ulcerans_Agy99 IEAVFRKGAYCAAYSGFEGVDHHGTTLEDWLRQRSIDAVDVVGVATDHCV
MAV_2472|M.avium_104 VDAVFRKGAYAAGYSGFEGVDDNGTPLLEWLRRRGVDEVDVVGIATDHCV
TH_1796|M.thermoresistible__bu IEAVFGKGQYSDGYSGFEGVDESGTPLAQWLRDHGVTRVDIVGIATDHCV
MAB_1472c|M.abscessus_ATCC_199 VDEVFSKGAYSAAYSGFEGVATDGTALAAWLHSRELNDVDVVGIATDYCV
:: ** ** : .****** *:.* **: : : **:**:***:**
Mflv_1089|M.gilvum_PYR-GCK KATAADAATAGFATRVLLDLTAGVSPSTTGAAIGALRAAGVVILP----
Mvan_5728|M.vanbaalenii_PYR-1 KATAADAAAAGFTTRVLSPLTAGVAPATTADALDTLRAAGVEVL-----
MSMEG_6506|M.smegmatis_MC2_155 AATAADAAGAGFATRVLTRLTAGVAPESTTAAVDQLRSAGVTIS-----
Rv2043c|M.tuberculosis_H37Rv RQTAEDAVRNGLATRVLVDLTAGVSADTTVAALEEMRTASVELVCSS--
Mb2069c|M.bovis_AF2122/97 RQTAEDAVRNGLATRVLVDLTAGVSADTTVAALEEMRTASVELVCSS--
MMAR_3016|M.marinum_M RQTAEGAVRAGFATRVLLDLTAGISAETTEVALARMRTAGVALVGSR--
MUL_2257|M.ulcerans_Agy99 RQTAEGAARAGFATRVLLDLTAGISAETTEVALAGMRTAGVALVGSR--
MAV_2472|M.avium_104 RRTAEDAARAGLTTRVLVHLTAAAAEDSAARALDEMRSAGIELVGAR--
TH_1796|M.thermoresistible__bu RATALDAVRHGFDTRVLVDYTAGVDADATARAVSELRDAGVAVTGSLAA
MAB_1472c|M.abscessus_ATCC_199 AATARDAAHEGLHTRVLTAYSVGISEESVNRALDELQRAGVEVIR----
** .*. *: **** :.. :. *: :: *.: :