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MRALIVVDVQNDFCEGGSLAVTGGAAVARGITELLAGDHGYDHVVATMDFHIDPGEHFSDTPDYQVSWPR HCVADTPGAEFHPEFDAGAVEVVFRKGHYSAAYSGFEGTDESGTTLADWLRERDVDAVDVVGIATDYCVA ATAADAAGAGFATRVLTRLTAGVAPESTTAAVDQLRSAGVTIS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6506 | - | - | 100% (183) | nicotinamidase/pyrazinamidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2069c | pncA | 6e-68 | 65.93% (182) | pyrazinamidase/nicotinamidas PNCA (PZase) |
| M. gilvum PYR-GCK | Mflv_1089 | - | 1e-75 | 74.19% (186) | isochorismatase hydrolase |
| M. tuberculosis H37Rv | Rv2043c | pncA | 5e-69 | 66.48% (182) | pyrazinamidase/nicotinamidas PNCA (PZase) |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1472c | - | 2e-62 | 63.54% (181) | putative nicotinamidase/pyrazinamidase |
| M. marinum M | MMAR_3016 | pncA | 6e-64 | 62.09% (182) | pyrazinamidase/nicotinamidase, PncA |
| M. avium 104 | MAV_2472 | - | 6e-65 | 63.19% (182) | isochorismatase family protein |
| M. thermoresistible (build 8) | TH_1796 | pncA | 1e-67 | 65.57% (183) | PYRAZINAMIDASE/NICOTINAMIDAS PNCA (PZase) |
| M. ulcerans Agy99 | MUL_2257 | pncA | 1e-62 | 60.99% (182) | pyrazinamidase/nicotinamidase, PncA |
| M. vanbaalenii PYR-1 | Mvan_5728 | - | 1e-75 | 74.59% (181) | isochorismatase hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1089|M.gilvum_PYR-GCK MSTPATTRALVIVDVQNDFCEGGSLAVDGGAAVARGISTLLGSLGIDGSH
Mvan_5728|M.vanbaalenii_PYR-1 MTS---NRTLIIVDVQNDFCEGGSLAVAGGAAVARGISDLLAS-----AP
MSMEG_6506|M.smegmatis_MC2_155 ------MRALIVVDVQNDFCEGGSLAVTGGAAVARGITELLAG-----DH
MMAR_3016|M.marinum_M ------MRALIIVDLQNDFCAGGALPVHNADLVARAINDYLAG-----SP
MUL_2257|M.ulcerans_Agy99 ------MRALVIVDLQNDFCAGGALPGQNADLVARAINDYLAG-----SP
MAV_2472|M.avium_104 ------MRALIIVDVQNDFCEGGSVPVAGGAAVAPAINAYLDD-----AP
Mb2069c|M.bovis_AF2122/97 ------MRALIIVDVQNDFCEGGSLAVTGGAALARAISDYLAE-----AA
Rv2043c|M.tuberculosis_H37Rv ------MRALIIVDVQNDFCEGGSLAVTGGAALARAISDYLAE-----AA
TH_1796|M.thermoresistible__bu ------MTALIIVDVQNDFCEGGALAVAGGATTARRISDLLRS-----ET
MAB_1472c|M.abscessus_ATCC_199 -----MGRALIVVDVQNDFCEGGSLSVPGGAALARTLNHLTRS------G
:*::**:***** **::. .. * :.
Mflv_1089|M.gilvum_PYR-GCK SYHHVVATKDFHIDPGAHFSDQPDYVDSWPVHCVAGSEGAEFHPDLDTAA
Mvan_5728|M.vanbaalenii_PYR-1 DYRHVVATKDFHIDPGPHFSDHPDYVDSWPVHCVAHTAGAEFHPDLDTTA
MSMEG_6506|M.smegmatis_MC2_155 GYDHVVATMDFHIDPGEHFSDTPDYQVSWPRHCVADTPGAEFHPEFDAGA
MMAR_3016|M.marinum_M GYDRVVATQDFHIDPGAHFSDSPDYSSSWPPHCRAGSTGAQFCPDLDVAP
MUL_2257|M.ulcerans_Agy99 GYDRVVAAQDFHIDPGAHFSDCPDYSSSWPPHCRAGSTGAQFCPDLDVAP
MAV_2472|M.avium_104 GYDYVVATQDFHIDPGDHFSDRPDYSSSWPAHCLAGSAGADFRPELDTTR
Mb2069c|M.bovis_AF2122/97 DYHHVVATKDFHIDPGDDFSGTPDYSSSWPPHCVSGTPGADFHPSLDTSA
Rv2043c|M.tuberculosis_H37Rv DYHHVVATKDFHIDPGDHFSGTPDYSSSWPPHCVSGTPGADFHPSLDTSA
TH_1796|M.thermoresistible__bu GYTHVVATKDQHIDPGDHFSDHPDFVRSWPRHCVAGTPGAEFHPDLDTGR
MAB_1472c|M.abscessus_ATCC_199 AYDAVVATRDFHVDPGGHFSENPDFQTSWPPHCRAGTPGADFHPYLDMGP
* ***: * *:*** .** **: *** ** : : **:* * :*
Mflv_1089|M.gilvum_PYR-GCK VEAVFYKGHYSAAYSGFEGTDDDGTSLADWLRERNVAAVDVVGIATDHCV
Mvan_5728|M.vanbaalenii_PYR-1 VEAVFKKGHHSAAYSGFEGKDDNGSALADWLRAHDVDAVDVVGIATDYCV
MSMEG_6506|M.smegmatis_MC2_155 VEVVFRKGHYSAAYSGFEGTDESGTTLADWLRERDVDAVDVVGIATDYCV
MMAR_3016|M.marinum_M IEAVFRKGAYCAAYSGFEGVDRHGTTLEDWLRQRSIDAVDVVGVATDHCV
MUL_2257|M.ulcerans_Agy99 IEAVFRKGAYCAAYSGFEGVDHHGTTLEDWLRQRSIDAVDVVGVATDHCV
MAV_2472|M.avium_104 VDAVFRKGAYAAGYSGFEGVDDNGTPLLEWLRRRGVDEVDVVGIATDHCV
Mb2069c|M.bovis_AF2122/97 IEAVFYKGAYTGAYSGFEGVDENGTPLLNWLRQRGVDEVDVVGIATDHCV
Rv2043c|M.tuberculosis_H37Rv IEAVFYKGAYTGAYSGFEGVDENGTPLLNWLRQRGVDEVDVVGIATDHCV
TH_1796|M.thermoresistible__bu IEAVFGKGQYSDGYSGFEGVDESGTPLAQWLRDHGVTRVDIVGIATDHCV
MAB_1472c|M.abscessus_ATCC_199 VDEVFSKGAYSAAYSGFEGVATDGTALAAWLHSRELNDVDVVGIATDYCV
:: ** ** : .****** *:.* **: : : **:**:***:**
Mflv_1089|M.gilvum_PYR-GCK KATAADAATAGFATRVLLDLTAGVSPSTTGAAIGALRAAGVVILP----
Mvan_5728|M.vanbaalenii_PYR-1 KATAADAAAAGFTTRVLSPLTAGVAPATTADALDTLRAAGVEVL-----
MSMEG_6506|M.smegmatis_MC2_155 AATAADAAGAGFATRVLTRLTAGVAPESTTAAVDQLRSAGVTIS-----
MMAR_3016|M.marinum_M RQTAEGAVRAGFATRVLLDLTAGISAETTEVALARMRTAGVALVGSR--
MUL_2257|M.ulcerans_Agy99 RQTAEGAARAGFATRVLLDLTAGISAETTEVALAGMRTAGVALVGSR--
MAV_2472|M.avium_104 RRTAEDAARAGLTTRVLVHLTAAAAEDSAARALDEMRSAGIELVGAR--
Mb2069c|M.bovis_AF2122/97 RQTAEDAVRNGLATRVLVDLTAGVSADTTVAALEEMRTASVELVCSS--
Rv2043c|M.tuberculosis_H37Rv RQTAEDAVRNGLATRVLVDLTAGVSADTTVAALEEMRTASVELVCSS--
TH_1796|M.thermoresistible__bu RATALDAVRHGFDTRVLVDYTAGVDADATARAVSELRDAGVAVTGSLAA
MAB_1472c|M.abscessus_ATCC_199 AATARDAAHEGLHTRVLTAYSVGISEESVNRALDELQRAGVEVIR----
** .*. *: **** :.. :. *: :: *.: :