For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
ACGVGISGCAIGSAIVLASIVAGVIDPANPGMAGLRRWLGPLSILLVLWGLRASIQWLQARLAQRGASAV IADLSGQVLTAVTARRPSQLAAQRDAAAVLITRGLDGLRPYFTGYLPTLLLAAILTPATVAVIGLYDLKS MAIVVITLPLIPIFMVLIGLATTNPSAAALAAMTAVQARLLDLIAGIPTLRALGRASGPEQRIAELSADH RRSAMATLRIAFLSALVLELLATLGVALVAVGIGLRLVFGEMSLTAGLTVLLLAPEVYWPLRRVGVQFHA AADGRTAADKAFALLGESPSPTPGRRTVTARGGVIRLERLSVRGRDGRAPYDLTADIEPGRVTVLTGRNG AGKSTTLQAIAGLTAPSSGRITVAGVDVTNLAPAAWWRQLSWLPQRPVLVPGTVRHNLVLLGPVDDLERA CAAAGFDAVLDELPRGLDTVLGRGGVGLSLGQRQRLGLARALGSPAAVLLLDEPTAHLDARTEQHVLGAI VERARAGATVLVVAHRQQVAAAGDRVVEVNSDGFRR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv1621c | cydD | - | 100% (527) | PROBABLE 'COMPONENT LINKED WITH THE ASSEMBLY OF CYTOCHROME' TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER CYDD |
M. tuberculosis H37Rv | Rv1272c | - | 4e-35 | 25.46% (491) | drugs-transport transmembrane ATP-binding protein ABC |
M. tuberculosis H37Rv | Rv1349 | - | 1e-34 | 27.72% (523) | drugs-transport transmembrane ATP-binding protein ABC |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1647c | cydD | 0.0 | 100.00% (527) | cytochrome' transport transmembrane ATP-binding protein ABC |
M. gilvum PYR-GCK | Mflv_3587 | - | 1e-171 | 62.50% (520) | ABC transporter, transmembrane region, type 1 |
M. leprae Br4923 | MLBr_01113 | - | 3e-29 | 23.79% (496) | putative ABC transporter, ATP-binding component |
M. abscessus ATCC 19977 | MAB_2632 | - | 1e-159 | 56.27% (526) | ABC transporter ATP-binding protein |
M. marinum M | MMAR_2424 | cydD | 0.0 | 75.95% (524) | cytochrome transmembrane ATP-binding protein ABC transporter |
M. avium 104 | MAV_3166 | cydD | 0.0 | 77.76% (526) | ABC transporter, CydDC cysteine exporter (CydDC-E) family |
M. smegmatis MC2 155 | MSMEG_3231 | cydD | 1e-175 | 64.09% (518) | ABC transporter, CydDC cysteine exporter (CydDC-E) family |
M. thermoresistible (build 8) | TH_2470 | - | 1e-174 | 64.16% (519) | PUTATIVE ABC transporter, transmembrane region, type 1 |
M. ulcerans Agy99 | MUL_1602 | cydD | 0.0 | 74.81% (524) | component linked with the assembly of cytochrome transport |
M. vanbaalenii PYR-1 | Mvan_2828 | - | 1e-169 | 62.69% (520) | ABC transporter, transmembrane region, type 1 |
CLUSTAL 2.0.9 multiple sequence alignment Rv1621c|M.tuberculosis_H37Rv -----------------------------------MACGVGISGCAIGS- Mb1647c|M.bovis_AF2122/97 -----------------------------------MACGVGISGCAIGS- MAV_3166|M.avium_104 ---------------------------MRRYLVAAVGCGVLISGCAIGS- MMAR_2424|M.marinum_M -----------------------------------MTCGVVISGCAIAS- MUL_1602|M.ulcerans_Agy99 -----------------------------------MTCGVVISGCAIAS- MSMEG_3231|M.smegmatis_MC2_155 ---------------------------------------MVIAGCTIAS- TH_2470|M.thermoresistible__bu ---------------------------MRRYLAASVAASTVIAAATIGS- Mflv_3587|M.gilvum_PYR-GCK ---------------------------MRRFLAATTAYGVLIAACTIAS- Mvan_2828|M.vanbaalenii_PYR-1 ---------------------------MRRFLIATTACGVLIAACTIAS- MAB_2632|M.abscessus_ATCC_1997 --------MTRPRGAPVDPRLWRRSAPARRYLFLTVLCELVMTGCTLVI- MLBr_01113|M.leprae_Br4923 MTMATAPATRSCDFYCTIRRLLKQLVPQRRLSLTVITLGITGTAIGIIVP :. : Rv1621c|M.tuberculosis_H37Rv -------AIVLASIVAGVIDPANPGMAGLRRWLGP--------------- Mb1647c|M.bovis_AF2122/97 -------AIVLASIVAGVIDPANPGMAGLRRWLGP--------------- MAV_3166|M.avium_104 -------AVVLAGIVARVVG--DTSAGEMRSWPAP--------------- MMAR_2424|M.marinum_M -------AIVLASMVARVAS--DPSARCLRCWLGS--------------- MUL_1602|M.ulcerans_Agy99 -------AIVLASMVARVAS--DPSARCLRCWLGS--------------- MSMEG_3231|M.smegmatis_MC2_155 -------AVVLAHIVAGIITNPATALGGETDWAPG--------------- TH_2470|M.thermoresistible__bu -------AVVLAGIVAGVITDPATRT--VAYWSDQ--------------- Mflv_3587|M.gilvum_PYR-GCK -------AVVLASLVARVVTDPVSRS--VEALAAP--------------- Mvan_2828|M.vanbaalenii_PYR-1 -------AVVLAGIVARVITDPASRS--VGELSTP--------------- MAB_2632|M.abscessus_ATCC_1997 -------AIVLAQALSQLITNPAARD--LPHMWQP--------------- MLBr_01113|M.leprae_Br4923 WVLGHTTDLLFNGVIGRQLPKGISKTQAVAAARTRGDNALADLLSGMNLV ::: :. . Rv1621c|M.tuberculosis_H37Rv -------------LSILLVLWGLRASIQWLQARLAQRGASAVIADLSGQV Mb1647c|M.bovis_AF2122/97 -------------LSILLVLWGLRASIQWLQARLAQRGASAVIADLSGQV MAV_3166|M.avium_104 -------------LSILLALWAVRAVAHWLQARLGQRGASAVIADLSGQV MMAR_2424|M.marinum_M -------------LLILSALWALRAVTHWLQARLGQRGASAVIAELSGQV MUL_1602|M.ulcerans_Agy99 -------------LLMLSALWALRAVTHWLQARLGQPGASAVIAELSGQV MSMEG_3231|M.smegmatis_MC2_155 -------------LVALAVLWSVRVVAQWFQGRLSQRGATAVIGELSRQV TH_2470|M.thermoresistible__bu -------------LALLTGLWLIRTGAHWQQGRLSQRGATAVIAELSSKV Mflv_3587|M.gilvum_PYR-GCK -------------LAILVSLWTVRVLAHWQQGRVAQHGASAVIADLTDQV Mvan_2828|M.vanbaalenii_PYR-1 -------------IAILLALWVFRALAQWRQGRLGQHGASAVIADLSDQV MAB_2632|M.abscessus_ATCC_1997 -------------IILLSALWALRALAHGVQVRFSERGATGVIADLDDQL MLBr_01113|M.leprae_Br4923 PGQGVDFVAVGRTLGLALSLYLVYTLLTWAQARLLNVTVQRIMFALRSDV : *: . . * *. : . :: * .: Rv1621c|M.tuberculosis_H37Rv LTAVTARRPSQLAAQ-RDAAAVLITRGLDGLRPYFTGYLPTLLLAAILTP Mb1647c|M.bovis_AF2122/97 LTAVTARRPSQLAAQ-RDAAAVLITRGLDGLRPYFTGYLPTLLLAAILTP MAV_3166|M.avium_104 LAAVTARPPAELAAQ-RDEAAVVVTRGLDGLRPYFTGYLPTLMLAAILTP MMAR_2424|M.marinum_M LESVTARQPNELAAQ-RDAAAVVVTRGLDGLRPYFTGYLPTLFLAAILTP MUL_1602|M.ulcerans_Agy99 LESVTARQPNELAAQ-RDAAAVVVTRGLDGLRPYFTGYLPTLFLAAILTP MSMEG_3231|M.smegmatis_MC2_155 LSSVTTSSPRRLAAD-RDSAAAVVTRGLDGLRPYFTGYLPAVVLAGILTP TH_2470|M.thermoresistible__bu LRTVTAAAPRDLAAA-RDRAAAVVTRGLDGLRPYFTGYLPTLFSAGILTP Mflv_3587|M.gilvum_PYR-GCK LRAATSLPPRELATR-RDEAAVVITRGLDGLRVYFTAYLPSLLLAVLLTP Mvan_2828|M.vanbaalenii_PYR-1 LTTATSLPPRQLAAH-RDEAAVVITRGLDGLRVYFTTYLPSLFLAAVLTP MAB_2632|M.abscessus_ATCC_1997 LSAVAQVQPRDLEQH-RDSATEVLTRGLDDLRPYFAGYLPALLSAAIVTP MLBr_01113|M.leprae_Br4923 EDKVHRLPLSYCDTRQRGELLSRVTNDIDNLQSSLSITLSQLLTSLLTVV . *. :*..:*.*: :: *. :. : : . Rv1621c|M.tuberculosis_H37Rv ATVAVIGLYDLKSMAIVVITLPLIPIFMVLIGLATTNPSAAALAAMTAVQ Mb1647c|M.bovis_AF2122/97 ATVAVIGLYDLKSMAIVVITLPLIPIFMVLIGLATTNPSAAALAAMTAVQ MAV_3166|M.avium_104 ATVAVIAAYDVKSTVIVAITLPLIPIFMVLIGLATRDRSAAALAAMTTLQ MMAR_2424|M.marinum_M ATVVMIAVYDVKSALIAVITLPLIPVFMVLIGLATAERSAAALAAMATLQ MUL_1602|M.ulcerans_Agy99 ATVVMIAVYDVKSALIAVITLPPIPVFMVLIGLATAERSAAALAAMATLQ MSMEG_3231|M.smegmatis_MC2_155 AALVVMAAYDWQAAAIVVIALPLIPIFMVLIGLLTAERSAAALTAMTTLQ TH_2470|M.thermoresistible__bu AAVFAIAWHDLQSAVTVLIVLPLIPLFMVLIGLTTRDHSAAALAAMTNLQ Mflv_3587|M.gilvum_PYR-GCK TTAAVIAWYDWRSAVIVAIALPLIPIFMILIGMATADRSEAALSAMTTLQ Mvan_2828|M.vanbaalenii_PYR-1 ATAVVIAFYDWKSALIVTIALPLIPVFMVLIGLATADRSAAALAAMATLQ MAB_2632|M.abscessus_ATCC_1997 AAAVVIALSDIRSALIVAITLPLIPVFMILIGLLTRDRAATALAASTAAT MLBr_01113|M.leprae_Br4923 AVLVVMVSVSPLLALVALLTVPMSLLATRAIAQRSQQLFVAQWTSAGRLN :. : . . :.:* : *. : : : :: Rv1621c|M.tuberculosis_H37Rv ARLLDLIAGIPTLRALGRASGPEQRIAELSADHRRSAMATLRIAFLSALV Mb1647c|M.bovis_AF2122/97 ARLLDLIAGIPTLRALGRASGPEQRIAELSADHRRSAMATLRIAFLSALV MAV_3166|M.avium_104 ARLLDLIAGIPTLRALGRSSGPDRSIAELAAAHRRSAMATLRIAFLSALV MMAR_2424|M.marinum_M ARLLDLIAGIPTLRALGRASGPEQRIAELSAAHRRSALATLRIAFLSALV MUL_1602|M.ulcerans_Agy99 ARLLDLIAGIPTLRALDRASGPEQRIAELSAAHRRSALATLRIAFLSAPV MSMEG_3231|M.smegmatis_MC2_155 GRMLDLIAGIPTLRAVGRAGGSVQRIAELSASHRRSTMATLRISFLSALV TH_2470|M.thermoresistible__bu NRTLDLIAGIPTLRALNRIDGSARRIAELVAAHRRSTMATLRIAFLSAFV Mflv_3587|M.gilvum_PYR-GCK SRLLDLVAGLPTLRALDRTRGAATRIAELSAAHRRSAMATMRIAFLSALV Mvan_2828|M.vanbaalenii_PYR-1 SRLLDLVAGLPTLRALGRTGGAAARIAELGAAHRRSAMATMRIAFLSALV MAB_2632|M.abscessus_ATCC_1997 GQIVDLIAGIPTLRALGRTATPLRRIAELGTAQRRSVMATLRVAFLSAMV MLBr_01113|M.leprae_Br4923 AHIEETYSGLTVVKTFGHQTAAREQFRNVNNDVYQASFSAQFFSGLVSPA : : :*:..:::..: . : :: :: ::: .: * : . Rv1621c|M.tuberculosis_H37Rv LELLATLGVALVAVGIGLRLVFGEMSLTAGLTVLLLAPEVYWPLRRVGVQ Mb1647c|M.bovis_AF2122/97 LELLATLGVALVAVGIGLRLVFGEMSLTAGLTVLLLAPEVYWPLRRVGVQ MAV_3166|M.avium_104 LELLATLGVALIAVGIGLRLVFGEMTLTAGLTVLLLAPDVYWPLRRIGVE MMAR_2424|M.marinum_M LELLATLGVAVIAVSIGLRLVFGEMTLTAGLTVLLLAPDVYWPLRRIGVE MUL_1602|M.ulcerans_Agy99 LELLATLGVAVIAVSIGLRLVFGEMTLTAGLTVLLLTPDVYWPLRRIGVE MSMEG_3231|M.smegmatis_MC2_155 LELLATLGVALVAVSVGLRLVFGDMTLAAGLTALLLAPEVFWPLRRVGAA TH_2470|M.thermoresistible__bu LELLATLSVALVAVGIGLRLVYGEMTLTAGLTALLLAPEVFWPLRRIGVE Mflv_3587|M.gilvum_PYR-GCK LELLATLGVALVAVGVGMRLVFGDMTLTAGLTALLLAPEAFWPLRRVGAA Mvan_2828|M.vanbaalenii_PYR-1 LELLATLGVALVAVGVGMRLVYGEMTLSAGLTALLLAPEVFWPLRRVGAA MAB_2632|M.abscessus_ATCC_1997 LEMIATLSVALIAVSIGMRLVFGHLDLTTALTVLILAPEVYWPLRRVGIQ MLBr_01113|M.leprae_Br4923 TMFISNLGYVVVAALGGLQVATGHITLGNIQAFIQYVRQFNMPLSQVAGI :::.*. .::*. *:::. *.: * : : . : ** ::. Rv1621c|M.tuberculosis_H37Rv FHAAADGRTAADKAFALLGESPSPTPGR-------RTVTARGGVIRLERL Mb1647c|M.bovis_AF2122/97 FHAAADGRTAADKAFALLGESPSPTPGR-------RTVTARGGVIRLERL MAV_3166|M.avium_104 FHAAQDGRTAAGAAFALIGEPGGPSAAKVRT----RTVTARGAPIRLEHL MMAR_2424|M.marinum_M FHAAQDGKSAADQAFTLIGETACTPPAR-------RAVTARGATIHLQNL MUL_1602|M.ulcerans_Agy99 FHAAQDGKSAADQAFTLIGETACTPPAR-------RAVTARGATIHLQNL MSMEG_3231|M.smegmatis_MC2_155 FHAAQDGKTAAEQALRLC-AEPHPPTGH-------EVVPAGAPVIEVP-- TH_2470|M.thermoresistible__bu FHAAQDGKAAADKAFELLDAAPRPAGGT-------RVVEAAGATIEVD-- Mflv_3587|M.gilvum_PYR-GCK FHSAQDGKTAVEAAFRFLDDAPASPAGT-------RAIPDHPLTVEVD-- Mvan_2828|M.vanbaalenii_PYR-1 FHSAQDGKTALQAAFRFIDTAEPPGAGT-------LGVPGDSVTVEVD-- MAB_2632|M.abscessus_ATCC_1997 FHSAADGTAAADRAFELLDTLTPSMPGPVAAP---VQAPPRRPTIGLEAI MLBr_01113|M.leprae_Br4923 YNTLQSGLASAERVFDLLDEPEELPDPMLALPPPHGQVPRINGRVEFQQV ::: .* :: .: : : . Rv1621c|M.tuberculosis_H37Rv SVRGRDGR-APYDLTADIEPGRVTVLTGRNGAGKSTTLQAIAGLTAPSSG Mb1647c|M.bovis_AF2122/97 SVRGRDGR-APYDLTADIEPGRVTVLTGRNGAGKSTTLQAIAGLTAPSSG MAV_3166|M.avium_104 SVAGRDGQ-APCDLSAVIEPGAVTVLTGRNGAGKSTTLQAIAGITAPSSG MMAR_2424|M.marinum_M SVTGRDGR-SPHNLTATIEPGQVTVLTGQNGAGKSTTLQLIAGLTTPSNG MUL_1602|M.ulcerans_Agy99 SVTGRDGR-SPHNLTATIEPGQVTVLTGQNGAGKSTTLQLIAGLTTPSNG MSMEG_3231|M.smegmatis_MC2_155 ------------ALKAVMEPGRVTVLTGPNGVGKSTLLQAILGLQESPCG TH_2470|M.thermoresistible__bu ------------ALTADLGPGCVTVLTGPNGVGKSSVLHTVLGLAPPLSG Mflv_3587|M.gilvum_PYR-GCK ------------DPALTAEPGRVTVLTGPNGAGKSTLLQAILGLGPPPTG Mvan_2828|M.vanbaalenii_PYR-1 ------------DPELTAGPGRVTVLTGPNGIGKSTLLQAILGLDRPTGG MAB_2632|M.abscessus_ATCC_1997 SVLDRGGY-APWELTATIRPGAVTVLTGHNGAGKSTALHAITGLAVPATG MLBr_01113|M.leprae_Br4923 SFAYRTGTPVIDDLSMVVEPGSTVAIVGPTGAGKTTLVNLLMRFYDVDSG ** ...:.* .* **:: :: : : * Rv1621c|M.tuberculosis_H37Rv RITVAGVDVTNLAPAAWWRQLSWLPQRPVLVPGTVRHNLVLLGPVD---D Mb1647c|M.bovis_AF2122/97 RITVAGVDVTNLAPAAWWRQLSWLPQRPVLVPGTVRHNLVLLGPVD---D MAV_3166|M.avium_104 RVTVGGVDVADLAPRGWWAQLSWLPQRPVLVPGTVDENLRLFGELD---D MMAR_2424|M.marinum_M RLTIAGIDISELDPVDWWRQLSWLPQRSVLIPGTVRDNLVLLGEPA---D MUL_1602|M.ulcerans_Agy99 RLTVAGIDISELDPVDWWRQLSWLPQRSVLIPGTVRDNLVLLGEPA---D MSMEG_3231|M.smegmatis_MC2_155 PILVAGVEVGALDRSAWWGRLAWMPHRPVLVPGTVRENLELLGPVP---G TH_2470|M.thermoresistible__bu SVRVGGVDIGELDLPAWWRQIAWLPHRPVLIPGTVRDNLSLFGPLE---D Mflv_3587|M.gilvum_PYR-GCK RIRVDGVEVAELDLRQWWTRVAWLAQRPVLIPGTVRDNLELFGPLP---D Mvan_2828|M.vanbaalenii_PYR-1 GIRINGVEVAELDPQQWWPKVAWLAQRPVLIPGTVQENLELFGPLP---D MAB_2632|M.abscessus_ATCC_1997 RVLLDGMTLEQIERDTWWSMIGWLPQRPVLIPGTVRENLEIFGQLE---D MLBr_01113|M.leprae_Br4923 QILIDGVDITTVSRHALRSRIGMVLQDAWLFDGTIAENIAYGRPQASEDE : : *: : : :. : : . *. **: .*: Rv1621c|M.tuberculosis_H37Rv LERACAAAGFDAVLDELPRGLDTVLGRGGVGLSLGQRQRLGLARALGSPA Mb1647c|M.bovis_AF2122/97 LERACAAAGFDAVLDELPRGLDTVLGRGGVGLSLGQRQRLGLARALGSPA MAV_3166|M.avium_104 IETACAIAGFDTVLAELPDAGATLLGRGGVGLSLGQRQRLGLARALGSRA MMAR_2424|M.marinum_M LDSACTASGFDAVLAELPDGLDTVLGRDGVGLSLGQRQRLALARVLGSPS MUL_1602|M.ulcerans_Agy99 LDSACAASGFDAVLAELPDGLDTVLGRDGVGLSLGQRQRLALARVLGSPS MSMEG_3231|M.smegmatis_MC2_155 LDEVCRSVGFDEVLGELPDGSETPLGRGGVGLSLGQRQRLGLVRALGAPA TH_2470|M.thermoresistible__bu PENAFRRSGFDEVLAALPDGMDTPLGRDGVGLSLGQRQRLGLARALGSPA Mflv_3587|M.gilvum_PYR-GCK LESACRAACFDEVLATLPDGADTVIGRGGVGLSLGQRQRLGLARVLGSPA Mvan_2828|M.vanbaalenii_PYR-1 LRSACRAACFDEVLATLPDGLQTVIGRGGVGLSLGQRQRLGLVRVLGSAA MAB_2632|M.abscessus_ATCC_1997 LESALADSQFDTVVAALPHGLDTRLGTGGAGLSLGERQRLSLARVLGTNR MLBr_01113|M.leprae_Br4923 VMEAAKAAYVDRFVHTLSAGYQTRVSGDGDNISAGEKQLITIARAFLARP . .* .: *. . * :. .* .:* *::* : :.*.: : Rv1621c|M.tuberculosis_H37Rv AVLLLDEPTAHLDARTEQHVLGAIVERARAGATVLVVAHRQQVAAAGDRV Mb1647c|M.bovis_AF2122/97 AVLLLDEPTAHLDARTEQHVLGAIVERARAGATVLVVAHRQQVAAAGDRV MAV_3166|M.avium_104 AVLLLDEPTAHLDAGTEERVLRAVVERARAGATVVVVGHREPVLAIGDRV MMAR_2424|M.marinum_M PVLLLDEPTAHLDSRTEEQVLQAIAERARTGATVVVVGHREPVVAIGDQV MUL_1602|M.ulcerans_Agy99 PVLLLDEPTAHLDSRTGEQVLQAIAERARTGATVVVVGHREPVVAICDQV MSMEG_3231|M.smegmatis_MC2_155 DVLLLDEPTAHLDGALEDRVLAAIVARARAGATVVMVGHRAPVLAAADHV TH_2470|M.thermoresistible__bu PVLLLDEPTAHLDAAMEARVLAAITDRARAGATVVVVGHREPVLSIADRV Mflv_3587|M.gilvum_PYR-GCK AVLLFDEPTAHLDGPTEARVLAAIARRAADGATVIVVGHRDPVLAIGDVV Mvan_2828|M.vanbaalenii_PYR-1 PLLLFDEPTAHLDGPTEARVLDAITRRAADGATVVVVGHRDPILEIGDAV MAB_2632|M.abscessus_ATCC_1997 PILLLDEPTAHLDADTEAAVLAALVSRARQGATVVLVGHRAPVLAAADEI MLBr_01113|M.leprae_Br4923 QLLILDEATSSIDTRTEALIARATHDLLQD-RTSFIIAHHLPTIRDADHI :*::**.*: :* : * * .::.*: * : Rv1621c|M.tuberculosis_H37Rv VEVNSDGFRR-------------------- Mb1647c|M.bovis_AF2122/97 VEVNSDGFRR-------------------- MAV_3166|M.avium_104 VAVSADRGARCAAA---------------- MMAR_2424|M.marinum_M VEVTRDGLDTQAGYVPV------------- MUL_1602|M.ulcerans_Agy99 VEVTRDGLDTQAGYVPV------------- MSMEG_3231|M.smegmatis_MC2_155 VTMESSLVAP-------------------- TH_2470|M.thermoresistible__bu VYLKEAAADAALAHR--------------- Mflv_3587|M.gilvum_PYR-GCK VDMGGARVPS-------------------- Mvan_2828|M.vanbaalenii_PYR-1 VRMGGARVAP-------------------- MAB_2632|M.abscessus_ATCC_1997 FTVQARHAANL------------------- MLBr_01113|M.leprae_Br4923 LVVAAGKIVEQGSHAKLLARRGAYYRMTQA . :